Motif ID: ZIC1..3.p2

Z-value: 0.979


Transcription factors associated with ZIC1..3.p2:

Gene SymbolEntrez IDGene Name
ZIC1 7545 Zic family member 1 (odd-paired homolog, Drosophila)
ZIC2 7546 Zic family member 2 (odd-paired homolog, Drosophila)
ZIC3 7547 Zic family member 3 (odd-paired homolog, Drosophila)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ZIC3hg19_v1_chrX_+_136648313_1366483450.661.5e-10Click!
ZIC1hg19_v1_chr3_+_147127151_1471271910.652.0e-10Click!
ZIC2hg19_v1_chr13_+_100634257_100634318-0.066.0e-01Click!


Activity profile for motif ZIC1..3.p2.

activity profile for motif ZIC1..3.p2


Sorted Z-values histogram for motif ZIC1..3.p2

Sorted Z-values for motif ZIC1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ZIC1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_45270071 9.422 NELL2
NEL-like 2 (chicken)
chr12_-_45270157 6.363 NM_001145108
NM_006159
NELL2

NEL-like 2 (chicken)

chr2_+_217498205 5.735 IGFBP2
insulin-like growth factor binding protein 2, 36kDa
chr12_-_45269953 5.362 NELL2
NEL-like 2 (chicken)
chr2_+_217498082 5.226 NM_000597
IGFBP2
insulin-like growth factor binding protein 2, 36kDa
chr5_-_134914447 4.407 CXCL14
chemokine (C-X-C motif) ligand 14
chr19_+_16435632 4.392 NM_016270
KLF2
Kruppel-like factor 2 (lung)
chr1_-_38512446 4.231 NM_002699
POU3F1
POU class 3 homeobox 1
chr8_+_75736771 4.116 NM_015886
PI15
peptidase inhibitor 15
chr12_-_45269340 4.025 NM_001145109
NELL2
NEL-like 2 (chicken)
chr8_-_124544376 3.996 NM_148177
FBXO32
F-box protein 32
chr9_+_135037015 3.971 NTNG2
netrin G2
chr19_-_51456159 3.953 NM_001077491
NM_001077492
NM_012427
KLK5


kallikrein-related peptidase 5


chr15_-_42448769 3.871 NM_213600
PLA2G4F
phospholipase A2, group IVF
chr19_+_16435734 3.827 KLF2
Kruppel-like factor 2 (lung)
chr12_-_45270632 3.717 NM_001145107
NELL2
NEL-like 2 (chicken)
chr4_-_174450529 3.685 HAND2
heart and neural crest derivatives expressed 2
chr7_+_27224163 3.610


chr4_-_174450343 3.610 HAND2
heart and neural crest derivatives expressed 2
chr1_-_40367539 3.321 NM_001033081
NM_001033082
NM_005376
MYCL1


v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)


chr17_-_3461030 3.126 TRPV3
transient receptor potential cation channel, subfamily V, member 3
chrX_-_17879355 2.907 NM_001172732
NM_001172739
NM_001172743
NM_021785
RAI2



retinoic acid induced 2



chr6_-_3456734 2.905 NM_015482
SLC22A23
solute carrier family 22, member 23
chr5_+_173416161 2.833 NM_001144954
C5orf47
chromosome 5 open reading frame 47
chr4_-_149363498 2.634 NM_000901
NM_001166104
NR3C2

nuclear receptor subfamily 3, group C, member 2

chr11_-_75379651 2.535 MAP6
microtubule-associated protein 6
chr17_-_3461288 2.519 NM_145068
TRPV3
transient receptor potential cation channel, subfamily V, member 3
chr6_-_3456513 2.491 SLC22A23
solute carrier family 22, member 23
chr8_-_22014263 2.485 NM_139278
LGI3
leucine-rich repeat LGI family, member 3
chr11_-_111782447 2.482 NM_001885
CRYAB
crystallin, alpha B
chr2_+_11682836 2.445 NM_033090
GREB1
growth regulation by estrogen in breast cancer 1
chrX_-_20135015 2.434 NM_001168465
NM_001168466
NM_152780
MAP7D2


MAP7 domain containing 2


chr4_-_149363304 2.370 NR3C2
nuclear receptor subfamily 3, group C, member 2
chr11_-_8615701 2.351 STK33
serine/threonine kinase 33
chr22_-_30685485 2.343 NM_001037666
GATSL3
GATS protein-like 3
chrX_-_107979606 2.340 NM_003604
IRS4
insulin receptor substrate 4
chr5_-_524444 2.317 NM_004174
SLC9A3
solute carrier family 9 (sodium/hydrogen exchanger), member 3
chr6_+_26021906 2.228 NM_003538
HIST1H4A
histone cluster 1, H4a
chr5_+_175792444 2.224 NM_173664
ARL10
ADP-ribosylation factor-like 10
chr15_-_76352068 2.175 NRG4
neuregulin 4
chr15_-_78933543 2.164 NM_000750
CHRNB4
cholinergic receptor, nicotinic, beta 4
chr17_-_37307694 2.140 PLXDC1
plexin domain containing 1
chr4_+_72052354 2.133 NM_001098484
NM_001134742
SLC4A4

solute carrier family 4, sodium bicarbonate cotransporter, member 4

chr1_+_151009028 2.120 NM_001159642
NM_138278
BNIPL

BCL2/adenovirus E1B 19kD interacting protein like

chr18_+_28898051 2.088 NM_001942
DSG1
desmoglein 1
chr1_+_201979747 2.082 ELF3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr9_+_100616192 2.067


chr11_-_26593667 2.042 NM_001135091
NM_001135092
NM_145650
MUC15


mucin 15, cell surface associated


chr7_+_44144002 2.034 AEBP1
AE binding protein 1
chr17_-_74533623 2.032 NM_134268
CYGB
cytoglobin
chr7_+_44143945 2.032 NM_001129
AEBP1
AE binding protein 1
chr11_-_8615412 2.031 NM_030906
STK33
serine/threonine kinase 33
chr22_-_44258210 2.014 NM_014351
SULT4A1
sulfotransferase family 4A, member 1
chr11_-_75379113 1.980 MAP6
microtubule-associated protein 6
chr1_+_212782103 1.978 ATF3
activating transcription factor 3
chr6_+_19838612 1.962


chr16_+_84224722 1.938 NM_001145400
NM_139174
ADAD2

adenosine deaminase domain containing 2

chr9_+_135037333 1.932 NM_032536
NTNG2
netrin G2
chr5_-_132948222 1.925 NM_015082
FSTL4
follistatin-like 4
chr1_+_164528914 1.923 PBX1
pre-B-cell leukemia homeobox 1
chr17_+_60705051 1.917 MRC2
mannose receptor, C type 2
chr12_+_119419299 1.881 NM_194286
SRRM4
serine/arginine repetitive matrix 4
chr11_-_119252364 1.870 NM_001243759
NM_004205
USP2

ubiquitin specific peptidase 2

chr19_-_35981345 1.868 NM_001244847
NM_207392
KRTDAP

keratinocyte differentiation-associated protein

chr17_-_56565700 1.857 NM_001080439
HSF5
heat shock transcription factor family member 5
chr1_+_152943127 1.853 NM_173080
SPRR4
small proline-rich protein 4
chr19_-_51568323 1.830 NM_015596
KLK13
kallikrein-related peptidase 13
chr11_-_75379414 1.801 NM_033063
NM_207577
MAP6

microtubule-associated protein 6

chr2_+_26915390 1.792 NM_002246
KCNK3
potassium channel, subfamily K, member 3
chr16_-_54318889 1.787 IRX3
iroquois homeobox 3
chr12_-_6809965 1.773 NM_001244014
NM_153685
C12orf53

chromosome 12 open reading frame 53

chr17_-_15244898 1.745 NM_031898
TEKT3
tektin 3
chr1_+_53099015 1.706 NM_001042693
FAM159A
family with sequence similarity 159, member A
chr7_+_330135 1.696 NM_001195127
LOC100288524
forkhead box L1-like
chr14_-_88789531 1.695 NM_138317
KCNK10
potassium channel, subfamily K, member 10
chr10_+_52751114 1.694 PRKG1
protein kinase, cGMP-dependent, type I
chr22_+_38201300 1.683 H1F0
H1 histone family, member 0
chr10_+_72432557 1.681 NM_080722
NM_139155
ADAMTS14

ADAM metallopeptidase with thrombospondin type 1 motif, 14

chr11_-_2158510 1.678 IGF2
insulin-like growth factor 2 (somatomedin A)
chr6_-_152623213 1.669 SYNE1
spectrin repeat containing, nuclear envelope 1
chr21_-_27945267 1.660 NM_052954
CYYR1
cysteine/tyrosine-rich 1
chr20_+_43029936 1.652 HNF4A
hepatocyte nuclear factor 4, alpha
chr19_+_13263890 1.649 IER2
immediate early response 2
chr11_-_64527369 1.647 PYGM
phosphorylase, glycogen, muscle
chr19_-_3869012 1.644 NM_001145640
NM_015174
ZFR2

zinc finger RNA binding protein 2

chr3_-_12200850 1.640 NM_003256
TIMP4
TIMP metallopeptidase inhibitor 4
chr1_-_108507474 1.616 NM_006113
VAV3
vav 3 guanine nucleotide exchange factor
chrX_+_70364707 1.615 NLGN3
neuroligin 3
chrX_+_70364680 1.601 NM_001166660
NM_018977
NM_181303
NLGN3


neuroligin 3


chrX_+_9432980 1.596 NM_005647
TBL1X
transducin (beta)-like 1X-linked
chr21_+_34442550 1.594 OLIG1
oligodendrocyte transcription factor 1
chr6_+_111408780 1.591 NM_018593
SLC16A10
solute carrier family 16, member 10 (aromatic amino acid transporter)
chr15_-_83316621 1.589 NM_030594
CPEB1
cytoplasmic polyadenylation element binding protein 1
chr1_+_13910251 1.588 NM_006474
NM_198389
PDPN

podoplanin

chr1_-_201081693 1.565 NM_000069
CACNA1S
calcium channel, voltage-dependent, L type, alpha 1S subunit
chr14_-_91720166 1.560 NM_003485
GPR68
G protein-coupled receptor 68
chr12_+_54447660 1.556 NM_153633
HOXC4
HOXC6
homeobox C4
homeobox C6
chr22_-_45404785 1.554 NM_001242450
PHF21B
PHD finger protein 21B
chr4_-_7436614 1.554 NM_001085382
PSAPL1
prosaposin-like 1 (gene/pseudogene)
chr9_+_37650996 1.553 NM_014907
FRMPD1
FERM and PDZ domain containing 1
chrX_+_70443055 1.545 NM_000166
GJB1
gap junction protein, beta 1, 32kDa
chr2_+_61108724 1.545 NM_002908
REL
v-rel reticuloendotheliosis viral oncogene homolog (avian)
chr2_+_61108702 1.543 REL
v-rel reticuloendotheliosis viral oncogene homolog (avian)
chr7_-_151107117 1.542 NM_198285
WDR86
WD repeat domain 86
chr4_+_47033294 1.540 NM_000812
GABRB1
gamma-aminobutyric acid (GABA) A receptor, beta 1
chr11_-_8615745 1.539 STK33
serine/threonine kinase 33
chr11_-_299518 1.527 NM_001025295
IFITM5
interferon induced transmembrane protein 5
chr16_-_30042123 1.526 NM_031478
FAM57B
family with sequence similarity 57, member B
chr12_-_6798419 1.521 ZNF384
zinc finger protein 384
chr21_-_36259224 1.510


chr5_+_161275541 1.504 NM_001127645
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr20_+_43030005 1.497 HNF4A
hepatocyte nuclear factor 4, alpha
chr1_+_116380404 1.497 NHLH2
nescient helix loop helix 2
chrX_+_70364728 1.494 NLGN3
neuroligin 3
chr3_+_64670779 1.485 ADAMTS9-AS2
ADAMTS9 antisense RNA 2 (non-protein coding)
chr6_-_6007632 1.484 NM_016588
NRN1
neuritin 1
chr1_-_25256364 1.481 RUNX3
runt-related transcription factor 3
chr19_+_55795533 1.476 NM_032430
BRSK1
BR serine/threonine kinase 1
chr11_-_119252267 1.468 USP2
ubiquitin specific peptidase 2
chr16_+_2521499 1.464 NM_006181
NTN3
netrin 3
chr1_-_236228382 1.461 NID1
nidogen 1
chr11_+_111783459 1.456 NM_001541
HSPB2-C11orf52
HSPB2
HSPB2-C11orf52 readthrough (non-protein coding)
heat shock 27kDa protein 2
chr2_+_61108775 1.452 REL
v-rel reticuloendotheliosis viral oncogene homolog (avian)
chr14_+_101292451 1.447 MEG3
maternally expressed 3 (non-protein coding)
chr17_-_72919244 1.442 NM_173477
USH1G
Usher syndrome 1G (autosomal recessive)
chr1_+_9352955 1.441 SPSB1
splA/ryanodine receptor domain and SOCS box containing 1
chr2_+_176987412 1.438 NM_014213
HOXD9
homeobox D9
chr1_+_11751778 1.436 NM_198545
C1orf187
chromosome 1 open reading frame 187
chr17_+_65040651 1.421 NM_000727
CACNG1
calcium channel, voltage-dependent, gamma subunit 1
chr9_-_123476578 1.419 NM_001080497
MEGF9
multiple EGF-like-domains 9
chr2_-_145274916 1.419 ZEB2
zinc finger E-box binding homeobox 2
chr17_+_6926366 1.411 NM_181844
BCL6B
B-cell CLL/lymphoma 6, member B
chr12_-_3862353 1.411 NM_001144958
NM_032680
EFCAB4B

EF-hand calcium binding domain 4B

chr7_+_103969103 1.411 NM_199000
LHFPL3
lipoma HMGIC fusion partner-like 3
chr2_-_27485774 1.410 NM_003459
SLC30A3
solute carrier family 30 (zinc transporter), member 3
chr2_+_16081945 1.409 MYCN
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
chr10_+_8097350 1.407 GATA3
GATA binding protein 3
chr22_+_38201232 1.405 H1F0
H1 histone family, member 0
chr22_+_21369441 1.397 NM_001159554
NM_005446
P2RX6

purinergic receptor P2X, ligand-gated ion channel, 6

chr2_-_109605668 1.392 NM_022336
EDAR
ectodysplasin A receptor
chr5_-_851100 1.392 NM_024786
ZDHHC11
zinc finger, DHHC-type containing 11
chr17_-_7197896 1.391 YBX2
Y box binding protein 2
chr3_+_101568325 1.387 NM_031419
NFKBIZ
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr1_-_45308603 1.379 NM_001166292
NM_003738
PTCH2

patched 2

chr11_-_106888829 1.376 NM_000855
GUCY1A2
guanylate cyclase 1, soluble, alpha 2
chr9_-_98278939 1.374 PTCH1
patched 1
chr18_+_13218777 1.367 NM_181481
NM_181482
C18orf1

chromosome 18 open reading frame 1

chr2_+_137523113 1.364 THSD7B
thrombospondin, type I, domain containing 7B
chr12_-_103310896 1.361 PAH
phenylalanine hydroxylase
chr19_-_2256415 1.355 NM_144616
JSRP1
junctional sarcoplasmic reticulum protein 1
chr21_+_34100388 1.354 GCFC1-AS1
GCFC1 antisense RNA 1 (non-protein coding)
chr17_+_6926414 1.351 BCL6B
B-cell CLL/lymphoma 6, member B
chr14_-_64761077 1.350 NM_001040275
NM_001437
ESR2

estrogen receptor 2 (ER beta)

chr12_-_48398284 1.349 NM_001844
NM_033150
COL2A1

collagen, type II, alpha 1

chr11_+_111783476 1.345 HSPB2-C11orf52
HSPB2
HSPB2-C11orf52 readthrough (non-protein coding)
heat shock 27kDa protein 2
chr22_+_32439018 1.344 NM_000343
SLC5A1
solute carrier family 5 (sodium/glucose cotransporter), member 1
chr21_+_34442446 1.341 NM_138983
OLIG1
oligodendrocyte transcription factor 1
chr19_+_45312294 1.340 NM_001013257
NM_005581
BCAM

basal cell adhesion molecule (Lutheran blood group)

chr7_-_4901437 1.333 NM_020144
PAPOLB
poly(A) polymerase beta (testis specific)
chr6_-_27841287 1.331 NM_003546
HIST1H4L
histone cluster 1, H4l
chr11_+_9596233 1.330 NM_001143976
WEE1
WEE1 homolog (S. pombe)
chr2_+_16082148 1.325 MYCN
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
chr21_-_34100210 1.323 SYNJ1
synaptojanin 1
chr3_-_12200339 1.322 TIMP4
TIMP metallopeptidase inhibitor 4
chr1_-_40105341 1.321 NM_014571
HEYL
hairy/enhancer-of-split related with YRPW motif-like
chr16_+_88705000 1.314 NM_013278
IL17C
interleukin 17C
chr8_-_143867931 1.311 NM_003695
LY6D
lymphocyte antigen 6 complex, locus D
chr2_+_219745243 1.308 NM_025216
WNT10A
wingless-type MMTV integration site family, member 10A
chrX_+_13587693 1.308 NM_001167890
NM_015507
EGFL6

EGF-like-domain, multiple 6

chr2_+_155555092 1.306 NM_002239
KCNJ3
potassium inwardly-rectifying channel, subfamily J, member 3
chr20_+_51589752 1.302 TSHZ2
teashirt zinc finger homeobox 2
chr17_-_37557851 1.297 NM_001184906
NM_032875
FBXL20

F-box and leucine-rich repeat protein 20

chr18_-_31803514 1.292 NM_001198546
NM_001198548
NM_003787
NOL4


nucleolar protein 4


chr12_-_6798528 1.284 NM_133476
ZNF384
zinc finger protein 384
chr20_-_35201677 1.269


chrX_-_128657453 1.266 NM_003069
NM_139035
SMARCA1

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1

chr2_-_145275086 1.265 ZEB2
zinc finger E-box binding homeobox 2
chr17_+_30593194 1.264 NM_138328
RHBDL3
rhomboid, veinlet-like 3 (Drosophila)
chr11_-_119234859 1.259 NM_171997
USP2
ubiquitin specific peptidase 2
chr1_-_40105296 1.257 HEYL
hairy/enhancer-of-split related with YRPW motif-like
chr11_+_64058772 1.255 NM_033310
KCNK4
potassium channel, subfamily K, member 4
chr3_+_121286777 1.254 NM_001012659
ARGFX
arginine-fifty homeobox
chr17_-_31620005 1.242 NM_183377
ACCN1
amiloride-sensitive cation channel 1, neuronal
chr12_-_132690572 1.241 NM_021808
GALNT9
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9 (GalNAc-T9)
chr11_+_123431036 1.240 GRAMD1B
GRAM domain containing 1B
chr16_+_55689899 1.239 SLC6A2
solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
chr1_-_202679415 1.234 NM_177402
SYT2
synaptotagmin II
chr16_+_639668 1.232 NM_001172664
RAB40C
RAB40C, member RAS oncogene family
chr11_+_7535000 1.229 NM_003621
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr12_-_3862217 1.228 EFCAB4B
EF-hand calcium binding domain 4B
chr2_+_27371858 1.225 NM_175769
TCF23
transcription factor 23
chr12_-_43945723 1.220 NM_025003
ADAMTS20
ADAM metallopeptidase with thrombospondin type 1 motif, 20
chrX_-_128657440 1.218 SMARCA1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
chr5_-_11903964 1.217 NM_001332
CTNND2
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
chr3_+_141496949 1.211 NM_139209
GRK7
G protein-coupled receptor kinase 7
chr3_+_39851028 1.210 NM_015460
MYRIP
myosin VIIA and Rab interacting protein
chr10_-_14879967 1.208 NM_001029954
CDNF
cerebral dopamine neurotrophic factor
chr20_+_43029865 1.208 NM_000457
NM_178849
NM_178850
HNF4A


hepatocyte nuclear factor 4, alpha


chr20_+_37434294 1.207 NM_001172735
NM_015568
PPP1R16B

protein phosphatase 1, regulatory subunit 16B

chr11_+_118478305 1.204 NM_001144758
NM_001144759
PHLDB1

pleckstrin homology-like domain, family B, member 1


Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
2.78 4.40e-04 GO:0006811 ion transport
1.51 2.04e-03 GO:0032501 multicellular organismal process
1.61 8.31e-03 GO:0032502 developmental process
1.68 9.09e-03 GO:0048856 anatomical structure development
1.59 3.85e-02 GO:0007275 multicellular organismal development
1.66 4.88e-02 GO:0048731 system development

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.92 3.17e-04 GO:0044459 plasma membrane part
2.85 2.21e-03 GO:0030054 cell junction
4.06 1.22e-02 GO:0034702 ion channel complex
2.02 1.81e-02 GO:0031226 intrinsic to plasma membrane
2.97 2.36e-02 GO:0045202 synapse
1.46 2.57e-02 GO:0071944 cell periphery
1.46 2.84e-02 GO:0005886 plasma membrane
1.99 3.00e-02 GO:0005887 integral to plasma membrane

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
3.16 3.73e-04 GO:0008324 cation transmembrane transporter activity
2.87 6.49e-04 GO:0043565 sequence-specific DNA binding
2.51 8.43e-04 GO:0022857 transmembrane transporter activity
4.08 1.82e-03 GO:0005261 cation channel activity
3.83 1.83e-03 GO:0022836 gated channel activity
2.40 1.96e-03 GO:0001071 nucleic acid binding transcription factor activity
2.40 1.96e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
2.61 3.11e-03 GO:0015075 ion transmembrane transporter activity
3.27 3.60e-03 GO:0015267 channel activity
3.27 3.72e-03 GO:0022803 passive transmembrane transporter activity
2.43 4.90e-03 GO:0022891 substrate-specific transmembrane transporter activity
2.17 5.18e-03 GO:0005215 transporter activity
3.23 7.61e-03 GO:0005216 ion channel activity
2.26 8.24e-03 GO:0030528 transcription regulator activity
3.18 9.17e-03 GO:0022838 substrate-specific channel activity
2.17 2.37e-02 GO:0022892 substrate-specific transporter activity
4.11 3.30e-02 GO:0005244 voltage-gated ion channel activity
4.11 3.30e-02 GO:0022832 voltage-gated channel activity