Motif ID: TLX2.p2

Z-value: 1.326


Transcription factors associated with TLX2.p2:

Gene SymbolEntrez IDGene Name
TLX2 3196 T-cell leukemia homeobox 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TLX2hg19_v1_chr2_+_74740585_747407170.191.1e-01Click!


Activity profile for motif TLX2.p2.

activity profile for motif TLX2.p2


Sorted Z-values histogram for motif TLX2.p2

Sorted Z-values for motif TLX2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TLX2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_+_151488214 6.625 LOC201651
arylacetamide deacetylase (esterase) pseudogene
chr1_-_31230594 6.525 LAPTM5
lysosomal protein transmembrane 5
chr6_-_33714681 5.265 NM_001142883
NM_054111
IP6K3

inositol hexakisphosphate kinase 3

chr10_+_124030820 5.141 NM_144587
BTBD16
BTB (POZ) domain containing 16
chr1_-_153283166 5.096 NM_052891
PGLYRP3
peptidoglycan recognition protein 3
chr5_+_159656436 4.798 NM_001445
FABP6
fatty acid binding protein 6, ileal
chr1_-_153363544 4.619 NM_002964
S100A8
S100 calcium binding protein A8
chr7_+_28448970 4.616 LOC401317
uncharacterized LOC401317
chr10_+_123754141 4.478 TACC2
transforming, acidic coiled-coil containing protein 2
chr17_-_80797889 4.389 NM_024702
ZNF750
zinc finger protein 750
chr11_-_2017822 4.290 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr18_+_28898051 4.214 NM_001942
DSG1
desmoglein 1
chr3_+_151531860 4.132 NM_001086
AADAC
arylacetamide deacetylase (esterase)
chr11_-_8615745 3.811 STK33
serine/threonine kinase 33
chr15_-_74494851 3.803 STRA6
stimulated by retinoic acid gene 6 homolog (mouse)
chrX_-_15620191 3.788 NM_021804
ACE2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr19_-_38878663 3.738 NM_152657
GGN
gametogenetin
chr15_-_74494780 3.717 STRA6
stimulated by retinoic acid gene 6 homolog (mouse)
chr7_-_99277518 3.614 NM_000777
NM_001190484
CYP3A5

cytochrome P450, family 3, subfamily A, polypeptide 5

chr11_-_8615701 3.600 STK33
serine/threonine kinase 33
chr11_-_8615412 3.522 NM_030906
STK33
serine/threonine kinase 33
chr12_-_48119224 3.449 NM_001172439
NM_001172440
NM_006025
ENDOU


endonuclease, polyU-specific


chr2_+_169923531 3.417 NM_199204
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr19_+_15160194 3.263 NM_012114
CASP14
caspase 14, apoptosis-related cysteine peptidase
chr1_-_120935893 3.245 FCGR1B
Fc fragment of IgG, high affinity Ib, receptor (CD64)
chr10_+_123872440 3.221 TACC2
transforming, acidic coiled-coil containing protein 2
chr16_+_84853585 3.169 NM_031476
CRISPLD2
cysteine-rich secretory protein LCCL domain containing 2
chr2_-_230933618 3.018 NM_152527
SLC16A14
solute carrier family 16, member 14 (monocarboxylic acid transporter 14)
chr7_-_99381703 2.947 NM_001202855
NM_017460
CYP3A4

cytochrome P450, family 3, subfamily A, polypeptide 4

chr20_+_3024267 2.885 NM_001501
NM_178331
NM_178332
GNRH2


gonadotropin-releasing hormone 2


chr15_-_31523049 2.847 NM_001243538
LOC283710
uncharacterized LOC283710
chr10_-_50396380 2.746 NM_001010863
C10orf128
chromosome 10 open reading frame 128
chr8_-_143823823 2.722 NM_020427
SLURP1
secreted LY6/PLAUR domain containing 1
chr1_-_153433104 2.712 NM_002963
S100A7
S100 calcium binding protein A7
chr1_+_153330329 2.706 NM_002965
S100A9
S100 calcium binding protein A9
chr14_-_23288912 2.641 NM_001126106
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr2_+_233243243 2.583 NM_001632
ALPP
alkaline phosphatase, placental
chr21_+_15399718 2.579


chr3_+_42544094 2.576 NM_001251883
NM_001251884
NM_001251885
NM_004624
VIPR1



vasoactive intestinal peptide receptor 1



chr7_+_37779995 2.567 NM_181791
GPR141
G protein-coupled receptor 141
chr8_+_133879202 2.531 NM_003235
TG
thyroglobulin
chr1_+_152943127 2.512 NM_173080
SPRR4
small proline-rich protein 4
chrX_-_20134749 2.506 NM_001168467
MAP7D2
MAP7 domain containing 2
chr19_-_51512803 2.487 NM_012315
KLK9
kallikrein-related peptidase 9
chr17_+_54230835 2.443 NM_153228
ANKFN1
ankyrin-repeat and fibronectin type III domain containing 1
chr1_+_152486977 2.420 NM_019060
CRCT1
cysteine-rich C-terminal 1
chr6_+_30951484 2.378 NM_001010909
MUC21
mucin 21, cell surface associated
chr5_+_79330990 2.342 NM_003248
THBS4
thrombospondin 4
chr14_-_91526731 2.331


chr17_+_34087915 2.284 NM_145272
C17orf50
chromosome 17 open reading frame 50
chr11_+_1860718 2.281 NM_001145829
TNNI2
troponin I type 2 (skeletal, fast)
chr11_+_123396479 2.271 NM_020716
GRAMD1B
GRAM domain containing 1B
chr14_-_53417272 2.267 FERMT2
fermitin family member 2
chr2_+_233271551 2.243 NM_031313
ALPPL2
alkaline phosphatase, placental-like 2
chr11_+_113930430 2.234 NM_006006
ZBTB16
zinc finger and BTB domain containing 16
chr1_-_204135420 2.226 NM_000537
REN
renin
chr3_+_42544131 2.190 VIPR1
vasoactive intestinal peptide receptor 1
chr1_+_151009028 2.124 NM_001159642
NM_138278
BNIPL

BCL2/adenovirus E1B 19kD interacting protein like

chrX_-_69269781 2.119 NM_001002254
AWAT2
acyl-CoA wax alcohol acyltransferase 2
chr16_-_69760367 2.103 NQO1
NAD(P)H dehydrogenase, quinone 1
chr6_-_32557431 2.066 NM_001243965
NM_002124
HLA-DRB1

HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1

major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr12_-_113658826 2.066 NM_138451
IQCD
IQ motif containing D
chr16_-_66551104 2.062 TK2
thymidine kinase 2, mitochondrial
chr2_-_175869910 2.047 NM_001822
NM_001025201
CHN1

chimerin (chimaerin) 1

chr12_+_85673884 1.943 NM_006982
ALX1
ALX homeobox 1
chr5_+_7396030 1.926 NM_020546
ADCY2
adenylate cyclase 2 (brain)
chr11_-_26593667 1.923 NM_001135091
NM_001135092
NM_145650
MUC15


mucin 15, cell surface associated


chr16_-_69760444 1.894 NM_000903
NM_001025433
NM_001025434
NQO1


NAD(P)H dehydrogenase, quinone 1


chr19_+_44080951 1.890 NM_001193621
LOC390940
uncharacterized protein ENSP00000244321
chr13_+_51915167 1.889 NM_001101320
SERPINE3
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3
chr5_-_11903964 1.887 NM_001332
CTNND2
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
chr1_+_24645811 1.851 NM_198173
NM_198174
GRHL3

grainyhead-like 3 (Drosophila)

chr21_+_35736322 1.846 NM_172201
KCNE2
potassium voltage-gated channel, Isk-related family, member 2
chr11_+_124481451 1.828 NM_052959
PANX3
pannexin 3
chr2_-_169887832 1.805 NM_003742
ABCB11
ATP-binding cassette, sub-family B (MDR/TAP), member 11
chr4_+_156680603 1.804 GUCY1B3
guanylate cyclase 1, soluble, beta 3
chr1_+_153388999 1.799 NM_176823
S100A7A
S100 calcium binding protein A7A
chr19_+_12305829 1.781 LOC100289333
uncharacterized LOC100289333
chr19_+_34112854 1.774 NM_001127895
NM_001127896
CHST8

carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8

chr14_+_78870092 1.768 NM_004796
NRXN3
neurexin 3
chr21_+_42688660 1.739 NM_058186
NM_206964
FAM3B

family with sequence similarity 3, member B

chr16_-_72206023 1.738 NM_031293
PMFBP1
polyamine modulated factor 1 binding protein 1
chr18_+_55862577 1.715 NM_001144970
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr2_+_233320832 1.712 NM_001631
ALPI
alkaline phosphatase, intestinal
chr1_+_160765927 1.707 NM_001033667
NM_002348
LY9

lymphocyte antigen 9

chr1_-_151826042 1.699 NM_182578
THEM5
thioesterase superfamily member 5
chr19_+_840970 1.697 NM_002777
PRTN3
proteinase 3
chr18_+_52258389 1.692 NM_173629
C18orf26
chromosome 18 open reading frame 26
chr15_+_48010685 1.678 NM_020858
NM_024966
NM_153616
NM_153617
NM_153618
NM_153619
SEMA6D





sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D





chr6_-_166401403 1.665 LINC00473
long intergenic non-protein coding RNA 473
chr3_+_186435097 1.663 NM_000893
NM_001102416
NM_001166451
KNG1


kininogen 1


chrX_+_152683780 1.659 NM_001136273
ZFP92
zinc finger protein 92 homolog (mouse)
chr3_+_5021141 1.654 BHLHE40
basic helix-loop-helix family, member e40
chr17_-_39211462 1.650 NM_033032
KRTAP2-2
keratin associated protein 2-2
chrX_-_110513750 1.644 NM_014289
CAPN6
calpain 6
chr8_+_63161185 1.638 NKAIN3
Na+/K+ transporting ATPase interacting 3
chr6_+_84562984 1.626 NM_001009994
RIPPLY2
ripply2 homolog (zebrafish)
chr3_+_5021305 1.610 BHLHE40
basic helix-loop-helix family, member e40
chr14_-_77542533 1.607


chr1_+_12185955 1.606 NM_152942
TNFRSF8
tumor necrosis factor receptor superfamily, member 8
chr19_+_35782988 1.605 NM_001199216
NM_002361
NM_080600
MAG


myelin associated glycoprotein


chr10_-_7708805 1.603 NM_001001851
NM_030569
ITIH5

inter-alpha-trypsin inhibitor heavy chain family, member 5

chr16_+_29789560 1.594 NM_152338
ZG16
zymogen granule protein 16 homolog (rat)
chr20_-_61885802 1.588 NM_152864
NKAIN4
Na+/K+ transporting ATPase interacting 4
chr11_+_60223281 1.571 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr19_+_1248548 1.567 NM_177401
MIDN
midnolin
chr12_-_104234783 1.563 NT5DC3
5'-nucleotidase domain containing 3
chr10_+_26727692 1.559 APBB1IP
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr7_+_113726592 1.548 FOXP2
forkhead box P2
chr4_-_149363498 1.548 NM_000901
NM_001166104
NR3C2

nuclear receptor subfamily 3, group C, member 2

chr3_-_22414122 1.538 ZNF385D
zinc finger protein 385D
chr1_-_79472360 1.536 NM_022159
ELTD1
EGF, latrophilin and seven transmembrane domain containing 1
chr3_+_126243161 1.528 CHST13
carbohydrate (chondroitin 4) sulfotransferase 13
chr3_-_170303774 1.528 NM_020949
SLC7A14
solute carrier family 7 (orphan transporter), member 14
chr7_+_113726364 1.526 FOXP2
forkhead box P2
chr2_-_190445466 1.524 SLC40A1
solute carrier family 40 (iron-regulated transporter), member 1
chr7_+_113726490 1.524 FOXP2
forkhead box P2
chr1_+_51435911 1.521 CDKN2C
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
chr12_-_8043743 1.520 SLC2A14
solute carrier family 2 (facilitated glucose transporter), member 14
chr7_-_135433366 1.519 NM_205855
FAM180A
family with sequence similarity 180, member A
chr11_-_18813127 1.517 NM_001039970
NM_006906
NM_032781
PTPN5


protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)


chrX_+_115567746 1.514 NM_007231
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr11_+_19372270 1.510 NM_001111018
NAV2
neuron navigator 2
chr7_+_37723378 1.509


chr7_+_73275488 1.508 NM_182504
WBSCR28
Williams-Beuren syndrome chromosome region 28
chr11_-_8190535 1.503 NM_001135109
NM_001206671
NM_001206672
NM_024557
RIC3



resistance to inhibitors of cholinesterase 3 homolog (C. elegans)



chr19_+_16999871 1.502 F2RL3
coagulation factor II (thrombin) receptor-like 3
chr2_-_139537803 1.500 NM_007226
NXPH2
neurexophilin 2
chr14_+_101292451 1.497 MEG3
maternally expressed 3 (non-protein coding)
chr15_-_29862926 1.495 NM_015307
FAM189A1
family with sequence similarity 189, member A1
chr12_+_48866447 1.487 NM_012404
ANP32D
acidic (leucine-rich) nuclear phosphoprotein 32 family, member D
chr3_+_184097860 1.481 NM_003741
CHRD
chordin
chr9_+_126118447 1.481 NM_173689
CRB2
crumbs homolog 2 (Drosophila)
chr9_-_34397786 1.479 NM_032596
C9orf24
chromosome 9 open reading frame 24
chr2_-_190445612 1.468 SLC40A1
solute carrier family 40 (iron-regulated transporter), member 1
chr15_-_27018216 1.449 NM_000814
GABRB3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr19_+_45251933 1.448 NM_005178
BCL3
B-cell CLL/lymphoma 3
chr9_-_33395265 1.445 AQP7
aquaporin 7
chr11_-_1036654 1.444 NM_005961
MUC6
mucin 6, oligomeric mucus/gel-forming
chr10_+_17794250 1.443 NM_001098844
TMEM236
transmembrane protein 236
chr3_+_2140449 1.443 NM_175607
CNTN4
contactin 4
chr1_+_15764934 1.441 NM_007272
CTRC
chymotrypsin C (caldecrin)
chr16_-_89007605 1.438 NM_175931
CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr2_+_131513782 1.435 NM_001105194
NM_001105195
FAM123C

family with sequence similarity 123C

chr15_+_74422920 1.435 ISLR2
immunoglobulin superfamily containing leucine-rich repeat 2
chr11_+_65082288 1.431 NM_006779
CDC42EP2
CDC42 effector protein (Rho GTPase binding) 2
chr15_-_40398286 1.426 NM_001003942
NM_001003943
BMF

Bcl2 modifying factor

chr1_+_86889768 1.425 NM_006536
CLCA2
chloride channel accessory 2
chrX_+_15518899 1.410 NM_203281
BMX
BMX non-receptor tyrosine kinase
chr20_+_2795613 1.407 NM_080739
C20orf141
chromosome 20 open reading frame 141
chr14_-_91526912 1.401 NM_004755
NM_182398
RPS6KA5

ribosomal protein S6 kinase, 90kDa, polypeptide 5

chr2_-_100720934 1.400 AFF3
AF4/FMR2 family, member 3
chr16_+_30386097 1.393 NM_013292
MYLPF
myosin light chain, phosphorylatable, fast skeletal muscle
chr17_+_25958257 1.392 LGALS9
lectin, galactoside-binding, soluble, 9
chr19_-_51920841 1.392 NM_001171156
NM_001171157
NM_001171158
NM_001171159
NM_001171160
NM_001171161
NM_033130
SIGLEC10






sialic acid binding Ig-like lectin 10






chr1_-_203055088 1.389 MYOG
myogenin (myogenic factor 4)
chr19_+_42221404 1.388 CEACAM5
carcinoembryonic antigen-related cell adhesion molecule 5
chr4_-_122148620 1.387 NM_001244764
TNIP3
TNFAIP3 interacting protein 3
chr19_-_59084928 1.383 NM_003422
NM_198055
MZF1

myeloid zinc finger 1

chrX_-_118827060 1.382 SEPT6
septin 6
chr20_+_37434294 1.382 NM_001172735
NM_015568
PPP1R16B

protein phosphatase 1, regulatory subunit 16B

chr3_-_128212027 1.381 NM_032638
GATA2
GATA binding protein 2
chr16_-_28074776 1.379 NM_001109763
GSG1L
GSG1-like
chr3_-_42814734 1.375 NM_144719
CCDC13
coiled-coil domain containing 13
chr3_-_122746309 1.374 SEMA5B
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B
chr1_+_16330730 1.372 NM_178840
C1orf64
chromosome 1 open reading frame 64
chr19_+_12305869 1.372


chr8_-_103667882 1.368 NM_005655
KLF10
Kruppel-like factor 10
chr17_-_9862765 1.368 NM_003644
GAS7
growth arrest-specific 7
chr19_+_50472856 1.364 SIGLEC16
sialic acid binding Ig-like lectin 16 (gene/pseudogene)
chr4_+_156680125 1.361 NM_000857
GUCY1B3
guanylate cyclase 1, soluble, beta 3
chr15_-_65360175 1.356 RASL12
RAS-like, family 12
chr9_+_34958320 1.355 KIAA1045
KIAA1045
chr9_-_129884961 1.354 ANGPTL2
angiopoietin-like 2
chr20_-_50418946 1.350 NM_020436
SALL4
sal-like 4 (Drosophila)
chr9_-_129884885 1.348 ANGPTL2
angiopoietin-like 2
chr19_-_36342894 1.341 NM_004646
NPHS1
nephrosis 1, congenital, Finnish type (nephrin)
chr19_+_16999807 1.341 NM_003950
F2RL3
coagulation factor II (thrombin) receptor-like 3
chrX_+_151806636 1.340 NM_018558
GABRQ
gamma-aminobutyric acid (GABA) receptor, theta
chr11_+_2323356 1.339 TSPAN32
tetraspanin 32
chr2_+_44066102 1.335 NM_022437
ABCG8
ATP-binding cassette, sub-family G (WHITE), member 8
chr17_+_25958245 1.332 LGALS9
lectin, galactoside-binding, soluble, 9
chr19_+_54369610 1.331 NM_001020820
MYADM
myeloid-associated differentiation marker
chr1_-_36851517 1.330 STK40
serine/threonine kinase 40
chr20_+_43029936 1.328 HNF4A
hepatocyte nuclear factor 4, alpha
chr6_-_116422408 1.328


chr19_+_58095507 1.321 NM_001010879
ZIK1
zinc finger protein interacting with K protein 1 homolog (mouse)
chr1_-_153348057 1.317 NM_005621
S100A12
S100 calcium binding protein A12
chr20_-_55841090 1.314 BMP7
bone morphogenetic protein 7
chr2_+_54558070 1.312 NM_001100396
C2orf73
chromosome 2 open reading frame 73
chr15_-_41805993 1.312 NM_001135685
NM_002344
NM_206961
LTK


leukocyte receptor tyrosine kinase


chr18_+_55711746 1.311 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr4_+_5053464 1.310 NM_018401
STK32B
serine/threonine kinase 32B
chr5_-_137610112 1.310 NM_001496
GFRA3
GDNF family receptor alpha 3
chr11_-_128712340 1.308 NM_000220
KCNJ1
potassium inwardly-rectifying channel, subfamily J, member 1
chr10_-_72043449 1.308 NM_022146
NPFFR1
neuropeptide FF receptor 1
chr16_-_72206348 1.306 NM_001160213
PMFBP1
polyamine modulated factor 1 binding protein 1
chr1_-_25291474 1.303 NM_001031680
RUNX3
runt-related transcription factor 3
chr10_-_64578926 1.302 NM_001136178
EGR2
early growth response 2
chr16_-_3142839 1.302 NM_032805
ZSCAN10
zinc finger and SCAN domain containing 10

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
7.76 2.98e-02 GO:0007588 excretion

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.67 9.49e-07 GO:0071944 cell periphery
1.66 1.94e-06 GO:0005886 plasma membrane
1.35 1.18e-04 GO:0016020 membrane
1.43 6.96e-04 GO:0031224 intrinsic to membrane
1.38 8.37e-04 GO:0044425 membrane part
5.38 1.10e-03 GO:0031225 anchored to membrane
1.79 1.96e-03 GO:0005576 extracellular region
1.37 1.28e-02 GO:0016021 integral to membrane
1.65 2.40e-02 GO:0044459 plasma membrane part

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
38.81 1.38e-05 GO:0019864 IgG binding
19.41 9.65e-04 GO:0019865 immunoglobulin binding
46.57 4.00e-03 GO:0004035 alkaline phosphatase activity
3.07 6.73e-03 GO:0030246 carbohydrate binding