• All motifs sorted by activity significance
• All samples sorted alphabetically
• Mean activities

• Activities table
• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)
• Download the whole report

Motif ID: TGIF1.p2

Z-value: 2.174

---

Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr17_-_39661803	26.031	NM_002274 NM_153490	KRT13	keratin 13
chr6_-_33714681	13.491	NM_001142883 NM_054111	IP6K3	inositol hexakisphosphate kinase 3
chr12_-_53074172	13.050	NM_006121	KRT1	keratin 1
chr11_+_129245834	12.758	NM_003658	BARX2	BARX homeobox 2
chr6_+_126070813	11.934		HEY2	hairy/enhancer-of-split related with YRPW motif 2
chr15_-_76352068	11.898		NRG4	neuregulin 4
chr1_-_11907741	11.837	NM_006172	NPPA	natriuretic peptide A
chr6_+_126070895	10.179		HEY2	hairy/enhancer-of-split related with YRPW motif 2
chr1_+_100111430	9.820	NM_017734	PALMD	palmdelphin
chr20_-_61002588	8.866	NM_080833	C20orf151	chromosome 20 open reading frame 151
chr6_+_30951484	8.071	NM_001010909	MUC21	mucin 21, cell surface associated
chr7_-_107770785	7.771	NM_007356	LAMB4	laminin, beta 4
chr11_-_26593667	7.687	NM_001135091 NM_001135092 NM_145650	MUC15	mucin 15, cell surface associated
chr20_-_9819406	7.556	NM_020341 NM_177990	PAK7	p21 protein (Cdc42/Rac)-activated kinase 7
chr1_+_152943127	7.254	NM_173080	SPRR4	small proline-rich protein 4
chr2_+_11682836	7.172	NM_033090	GREB1	growth regulation by estrogen in breast cancer 1
chr1_+_18807423	7.057	NM_152375	KLHDC7A	kelch domain containing 7A
chr12_+_55248298	6.836	NM_058173	MUCL1	mucin-like 1
chr8_-_124665165	6.784	NM_001081675	KLHL38	kelch-like 38 (Drosophila)
chr14_-_73360792	6.535	NM_012074	DPF3	D4, zinc and double PHD fingers, family 3
chr1_+_153388999	6.482	NM_176823	S100A7A	S100 calcium binding protein A7A
chr6_+_136172802	6.466	NM_018945	PDE7B	phosphodiesterase 7B
chr10_+_123872440	6.357		TACC2	transforming, acidic coiled-coil containing protein 2
chr1_+_228871109	6.127		RHOU	ras homolog gene family, member U
chr6_-_41863086	6.091	NM_018561	USP49	ubiquitin specific peptidase 49
chr1_+_149754245	6.091	NM_000566	FCGR1A	Fc fragment of IgG, high affinity Ia, receptor (CD64)
chr20_+_20037289	5.648	NM_001167816	C20orf26	chromosome 20 open reading frame 26
chr2_+_233243243	5.619	NM_001632	ALPP	alkaline phosphatase, placental
chr6_-_41130921	5.551	NM_018965	TREM2	triggering receptor expressed on myeloid cells 2
chr8_-_82395401	5.472	NM_001442	FABP4	fatty acid binding protein 4, adipocyte
chr1_+_9415944	5.445
chr6_-_41130820	5.434		TREM2	triggering receptor expressed on myeloid cells 2
chr2_+_11682787	5.408		GREB1	growth regulation by estrogen in breast cancer 1
chr12_-_63328663	5.200	NM_020700	PPM1H	protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr16_-_79634610	5.177	NM_001031804 NM_005360	MAF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)
chr17_+_28256873	5.074	NM_001145053	EFCAB5	EF-hand calcium binding domain 5
chr22_-_42828362	4.982	NM_145912	NFAM1	NFAT activating protein with ITAM motif 1
chrX_-_153775427	4.973		G6PD	glucose-6-phosphate dehydrogenase
chr20_+_43343523	4.936		WISP2	WNT1 inducible signaling pathway protein 2
chr6_+_41020939	4.898	NM_006789	APOBEC2	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
chr7_-_42276617	4.839	NM_000168	GLI3	GLI family zinc finger 3
chr6_-_41130864	4.716		TREM2	triggering receptor expressed on myeloid cells 2
chr2_-_188312872	4.661	NM_005795	CALCRL	calcitonin receptor-like
chr5_-_95748688	4.635	NM_001177876	PCSK1	proprotein convertase subtilisin/kexin type 1
chrX_+_9754465	4.619	NM_001649	SHROOM2	shroom family member 2
chr12_-_25348031	4.613	NM_001082972 NM_001082973 NM_001204101 NM_001204102 NM_018272	CASC1	cancer susceptibility candidate 1
chr7_-_80141241	4.574	NM_001102386	GNAT3	guanine nucleotide binding protein, alpha transducing 3
chr1_-_120935943	4.502	NM_001004340 NM_001017986 NM_001244910	FCGR1A FCGR1B	Fc fragment of IgG, high affinity Ia, receptor (CD64) Fc fragment of IgG, high affinity Ib, receptor (CD64)
chr10_-_69597768	4.457	NM_021800 NM_201262	DNAJC12	DnaJ (Hsp40) homolog, subfamily C, member 12
chr9_-_33447527	4.431	NM_004925	AQP3	aquaporin 3 (Gill blood group)
chr3_+_195451097	4.413	NM_001098516	MUC20	mucin 20, cell surface associated
chr10_-_73848766	4.317	NM_001134434 NM_014767	SPOCK2	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chrX_+_9754534	4.314		SHROOM2	shroom family member 2
chr15_+_45028559	4.288	NM_080745 NM_182985	TRIM69	tripartite motif containing 69
chr20_+_43344005	4.284		WISP2	WNT1 inducible signaling pathway protein 2
chr2_+_233925035	4.257	NM_001017915 NM_005541	INPP5D	inositol polyphosphate-5-phosphatase, 145kDa
chr6_-_13295817	4.221	NM_001242698	LOC100130357	uncharacterized LOC100130357
chr14_+_100150596	4.153	NM_006668	CYP46A1	cytochrome P450, family 46, subfamily A, polypeptide 1
chr2_+_233925104	4.145		INPP5D	inositol polyphosphate-5-phosphatase, 145kDa
chr1_+_51435911	4.119		CDKN2C	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
chr18_-_56296188	4.113	NM_052947	ALPK2	alpha-kinase 2
chr1_-_20306093	4.104	NM_001161729	PLA2G2A	phospholipase A2, group IIA (platelets, synovial fluid)
chr11_-_2018568	4.102		H19	H19, imprinted maternally expressed transcript (non-protein coding)
chr7_+_33945111	4.095	NM_133468	BMPER	BMP binding endothelial regulator
chr5_-_154230157	4.025		C5orf4	chromosome 5 open reading frame 4
chr12_-_57443858	4.018	NM_005379	MYO1A	myosin IA
chr18_+_31158540	4.000	NM_030632	ASXL3	additional sex combs like 3 (Drosophila)
chrX_-_154563735	3.969	NM_001289	CLIC2	chloride intracellular channel 2
chr1_-_54871681	3.969		SSBP3	single stranded DNA binding protein 3
chr3_+_45067750	3.965	NM_003278	CLEC3B	C-type lectin domain family 3, member B
chr7_-_50628744	3.950	NM_000790 NM_001242886 NM_001242887 NM_001242888 NM_001242889 NM_001242890	DDC	dopa decarboxylase (aromatic L-amino acid decarboxylase)
chr5_-_112824526	3.939	NM_001085377	MCC	mutated in colorectal cancers
chr18_+_13611664	3.921	NM_001003674 NM_001003675	C18orf1	chromosome 18 open reading frame 1
chr1_-_153433104	3.918	NM_002963	S100A7	S100 calcium binding protein A7
chr1_+_226016428	3.875		EPHX1	epoxide hydrolase 1, microsomal (xenobiotic)
chr7_+_1272552	3.857	NM_001080461	UNCX	UNC homeobox
chr20_-_35201677	3.857
chr16_+_27413482	3.847	NM_181078 NM_181079	IL21R	interleukin 21 receptor
chr7_+_30951414	3.845	NM_198098	AQP1	aquaporin 1 (Colton blood group)
chr3_+_48413708	3.840	NM_001159927 NM_001159929 NM_207102	FBXW12	F-box and WD repeat domain containing 12
chr6_-_109415514	3.840	NM_014454	SESN1	sestrin 1
chrX_+_150345055	3.830	NM_004224	GPR50	G protein-coupled receptor 50
chr1_+_24645914	3.826	NM_001195010	GRHL3	grainyhead-like 3 (Drosophila)
chr17_-_66951381	3.804	NM_007168	ABCA8	ATP-binding cassette, sub-family A (ABC1), member 8
chr4_-_82126200	3.802	NM_006259	PRKG2	protein kinase, cGMP-dependent, type II
chr1_+_51434231	3.796	NM_001262	CDKN2C	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
chr6_+_73076431	3.791	NM_001168411	RIMS1	regulating synaptic membrane exocytosis 1
chr4_-_185747051	3.780		ACSL1	acyl-CoA synthetase long-chain family member 1
chr16_+_66995099	3.749	NM_001185177 NM_024922	CES3	carboxylesterase 3
chr1_+_66458389	3.743	NM_001037340	PDE4B	phosphodiesterase 4B, cAMP-specific
chr18_-_31158150	3.735
chr1_+_51435641	3.729	NM_078626	CDKN2C	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
chr1_-_16344438	3.710		HSPB7	heat shock 27kDa protein family, member 7 (cardiovascular)
chr17_-_39156106	3.669	NM_031959	KRTAP3-2	keratin associated protein 3-2
chr10_-_73848530	3.659	NM_001244950	SPOCK2	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr16_+_29789560	3.650	NM_152338	ZG16	zymogen granule protein 16 homolog (rat)
chr1_-_120935893	3.631		FCGR1B	Fc fragment of IgG, high affinity Ib, receptor (CD64)
chr22_-_36013303	3.629	NM_005368 NM_203378	MB	myoglobin
chr3_+_160473286	3.620		PPM1L	protein phosphatase, Mg2+/Mn2+ dependent, 1L
chr1_-_54872075	3.614	NM_001009955	SSBP3	single stranded DNA binding protein 3
chr20_-_5295014	3.586	NM_144773	PROKR2	prokineticin receptor 2
chr1_+_156252725	3.576		TMEM79	transmembrane protein 79
chr1_-_54871978	3.557	NM_018070 NM_145716	SSBP3	single stranded DNA binding protein 3
chr7_-_42276793	3.518		GLI3	GLI family zinc finger 3
chr4_+_2420671	3.484	NM_001193282	LOC402160	uncharacterized LOC402160
chr13_-_36429798	3.461	NM_001195415 NM_001195416 NM_001195430	DCLK1	doublecortin-like kinase 1
chr1_+_163038395	3.456	NM_001102445	RGS4	regulator of G-protein signaling 4
chrX_+_115567820	3.434		SLC6A14	solute carrier family 6 (amino acid transporter), member 14
chr19_+_51728319	3.434	NM_001082618 NM_001177608 NM_001772	CD33	CD33 molecule
chrX_-_153775774	3.386	NM_001042351	G6PD	glucose-6-phosphate dehydrogenase
chr2_+_169929009	3.370	NM_001142270	DHRS9	dehydrogenase/reductase (SDR family) member 9
chr11_-_111249902	3.331		POU2AF1	POU class 2 associating factor 1
chr16_+_50776012	3.323	NM_001042412	CYLD	cylindromatosis (turban tumor syndrome)
chr3_-_143567163	3.302	NM_173653	SLC9A9	solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr1_-_22469414	3.293	NM_030761	WNT4	wingless-type MMTV integration site family, member 4
chr5_-_169724817	3.276	NM_005565	LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr7_+_26438186	3.268		LOC441204	uncharacterized LOC441204
chr2_+_74740585	3.260		TLX2	T-cell leukemia homeobox 2
chr1_-_145039631	3.243	NM_001198832	PDE4DIP	phosphodiesterase 4D interacting protein
chr2_+_234668914	3.241	NM_000463	UGT1A1	UDP glucuronosyltransferase 1 family, polypeptide A1
chr7_-_27192201	3.234
chr22_+_41763299	3.227	NM_001145398	TEF	thyrotrophic embryonic factor
chr3_+_69788562	3.196	NM_198159	MITF	microphthalmia-associated transcription factor
chr16_+_50775960	3.189	NM_001042355 NM_015247	CYLD	cylindromatosis (turban tumor syndrome)
chr8_+_28174648	3.187	NM_006228	PNOC	prepronociceptin
chr17_-_38210888	3.169	NM_001079518 NM_014815	MED24	mediator complex subunit 24
chr17_+_68165660	3.167	NM_000891	KCNJ2	potassium inwardly-rectifying channel, subfamily J, member 2
chr2_+_8822112	3.151	NM_002166	ID2	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
chr19_+_48972574	3.147		CYTH2	cytohesin 2
chr2_+_211421322	3.146	NM_001875	CPS1	carbamoyl-phosphate synthase 1, mitochondrial
chr14_-_50474237	3.138	NM_001012706	C14orf182	chromosome 14 open reading frame 182
chr4_+_47033294	3.130	NM_000812	GABRB1	gamma-aminobutyric acid (GABA) A receptor, beta 1
chr22_-_39052579	3.130	NM_001013647	LOC646851	putative uncharacterized protein LOC388900
chrX_+_115567746	3.125	NM_007231	SLC6A14	solute carrier family 6 (amino acid transporter), member 14
chr19_+_51728369	3.104		CD33	CD33 molecule
chr3_-_187871816	3.104		LPP-AS2	LPP antisense RNA 2 (non-protein coding)
chr3_+_188664939	3.101		TPRG1	tumor protein p63 regulated 1
chr1_+_145549208	3.097	NM_144698	ANKRD35	ankyrin repeat domain 35
chr19_+_15160194	3.074	NM_012114	CASP14	caspase 14, apoptosis-related cysteine peptidase
chr1_-_198906536	3.072		LOC100131234	familial acute myelogenous leukemia related factor
chr16_-_67217825	3.055	NM_001040715	KIAA0895L	KIAA0895-like
chr5_-_88199868	3.051	NM_001131005 NM_001193347	MEF2C	myocyte enhancer factor 2C
chr3_-_146187087	3.045	NM_001199978	PLSCR2	phospholipid scramblase 2
chr11_-_111250156	3.042	NM_006235	POU2AF1	POU class 2 associating factor 1
chr5_-_154230212	3.039	NM_032385	C5orf4	chromosome 5 open reading frame 4
chr12_-_63328857	3.037		PPM1H	protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr20_+_43803539	3.032	NM_002638	PI3	peptidase inhibitor 3, skin-derived
chr9_+_35042222	3.031	NM_001040410 NM_203299	C9orf131	chromosome 9 open reading frame 131
chr19_-_47164289	3.014	NM_145056	DACT3	dapper, antagonist of beta-catenin, homolog 3 (Xenopus laevis)
chr1_-_38412704	3.005		INPP5B	inositol polyphosphate-5-phosphatase, 75kDa
chr11_+_73661363	3.003	NM_153614	DNAJB13	DnaJ (Hsp40) homolog, subfamily B, member 13
chr5_-_132948222	2.995	NM_015082	FSTL4	follistatin-like 4
chr17_-_53809444	2.992	NM_001099640	TMEM100	transmembrane protein 100
chr3_+_195447810	2.989		MUC20	mucin 20, cell surface associated
chr5_-_169724734	2.987		LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr11_-_20181869	2.964	NM_001029865	DBX1	developing brain homeobox 1
chr19_+_39786964	2.959	NM_172140	IL29	interleukin 29 (interferon, lambda 1)
chr19_+_49375679	2.939		PPP1R15A	protein phosphatase 1, regulatory subunit 15A
chr11_-_2018885	2.935		H19 RPS12	H19, imprinted maternally expressed transcript (non-protein coding) ribosomal protein S12
chr1_-_38412667	2.933		INPP5B	inositol polyphosphate-5-phosphatase, 75kDa
chr1_-_38412725	2.919	NM_005540	INPP5B	inositol polyphosphate-5-phosphatase, 75kDa
chr11_-_101000457	2.916	NM_000926	PGR	progesterone receptor
chr2_-_71454200	2.914	NM_020459	PAIP2B	poly(A) binding protein interacting protein 2B
chr6_+_99282579	2.908	NM_005604	POU3F2	POU class 3 homeobox 2
chr19_+_49375677	2.880		PPP1R15A	protein phosphatase 1, regulatory subunit 15A
chr6_-_24936177	2.864		FAM65B	family with sequence similarity 65, member B
chr1_-_38412720	2.863		INPP5B	inositol polyphosphate-5-phosphatase, 75kDa
chr19_-_45826131	2.860		CKM	creatine kinase, muscle
chr1_+_24645811	2.858	NM_198173 NM_198174	GRHL3	grainyhead-like 3 (Drosophila)
chr5_+_115298136	2.852	NM_173800	AQPEP	laeverin
chr1_+_26348265	2.851	NM_004455	EXTL1	exostoses (multiple)-like 1
chr11_+_19734821	2.833	NM_001244963 NM_145117 NM_182964	NAV2	neuron navigator 2
chr18_-_51880942	2.829	NM_139171	STARD6	StAR-related lipid transfer (START) domain containing 6
chr5_-_169724782	2.827		LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr14_-_23284617	2.820		SLC7A7	solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr8_+_42552561	2.817	NM_000749	CHRNB3	cholinergic receptor, nicotinic, beta 3
chr16_-_67217403	2.807		KIAA0895L	KIAA0895-like
chr8_+_30496116	2.798	NM_001206847	LOC100507341	uncharacterized LOC100507341
chr1_-_182030749	2.790	NM_001009992	ZNF648	zinc finger protein 648
chr19_-_7766978	2.783	NM_001220500 NM_002002	FCER2	Fc fragment of IgE, low affinity II, receptor for (CD23)
chr20_+_43343884	2.780	NM_003881	WISP2	WNT1 inducible signaling pathway protein 2
chr1_-_153123426	2.779	NM_001014291	SPRR2G	small proline-rich protein 2G
chr20_+_51588945	2.766	NM_173485	TSHZ2	teashirt zinc finger homeobox 2
chr7_+_95115212	2.763	NM_016116 NM_145872	ASB4	ankyrin repeat and SOCS box containing 4
chr10_-_73848278	2.750		SPOCK2	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr11_-_74442185	2.729	NM_015424	CHRDL2	chordin-like 2
chr3_-_183273407	2.728	NM_130446	KLHL6	kelch-like 6 (Drosophila)
chr1_+_26348308	2.723		EXTL1	exostoses (multiple)-like 1
chr6_-_84418492	2.706		SNAP91	synaptosomal-associated protein, 91kDa homolog (mouse)
chr9_+_125512018	2.703	NM_001004453	OR1L6	olfactory receptor, family 1, subfamily L, member 6
chrX_+_109662284	2.692	NM_020769	RGAG1	retrotransposon gag domain containing 1
chr15_+_65337707	2.692	NM_178859	OSTBETA	organic solute transporter beta
chr2_-_77749335	2.692	NM_001134745 NM_024993	LRRTM4	leucine rich repeat transmembrane neuronal 4
chr7_+_330135	2.678	NM_001195127	LOC100288524	forkhead box L1-like
chr1_-_108507474	2.657	NM_006113	VAV3	vav 3 guanine nucleotide exchange factor
chr8_-_67090690	2.656	NM_000756	CRH	corticotropin releasing hormone
chr7_-_100493481	2.654	NM_000665 NM_015831	ACHE	acetylcholinesterase
chr5_+_43192326	2.639	NM_153361	NIM1	serine/threonine-protein kinase NIM1
chr2_+_71162995	2.635	NM_001692	ATP6V1B1	ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1
chr9_+_116207010	2.621	NM_144488	RGS3	regulator of G-protein signaling 3

Gene overrepresentation in process category:

Enrichment	P-value	GO Accession	GO Term
1.45	1.20e-09	GO:0050896	response to stimulus
1.47	5.56e-08	GO:0032501	multicellular organismal process
1.30	6.57e-06	GO:0065007	biological regulation
1.50	3.60e-05	GO:0023052	signaling
1.60	4.58e-05	GO:0048731	system development
1.49	5.22e-05	GO:0032502	developmental process
1.45	1.33e-04	GO:0051716	cellular response to stimulus
1.50	1.36e-04	GO:0007275	multicellular organismal development
1.53	1.48e-04	GO:0048856	anatomical structure development
1.68	1.59e-04	GO:0065008	regulation of biological quality
3.04	2.08e-04	GO:0051093	negative regulation of developmental process
1.50	2.35e-04	GO:0007165	signal transduction
1.27	3.85e-04	GO:0050789	regulation of biological process
1.28	7.59e-04	GO:0050794	regulation of cellular process
31.45	1.81e-03	GO:0015793	glycerol transport
3.08	2.03e-03	GO:0045596	negative regulation of cell differentiation
4.74	2.47e-03	GO:0050851	antigen receptor-mediated signaling pathway
1.58	3.46e-03	GO:0042221	response to chemical stimulus
1.64	4.62e-03	GO:0048513	organ development
1.81	5.68e-03	GO:0002376	immune system process
4.36	6.77e-03	GO:0002429	immune response-activating cell surface receptor signaling pathway
25.16	8.82e-03	GO:0003097	renal water transport
1.58	1.07e-02	GO:0030154	cell differentiation
4.19	1.08e-02	GO:0002768	immune response-regulating cell surface receptor signaling pathway
1.92	1.56e-02	GO:0050793	regulation of developmental process
7.40	1.57e-02	GO:0045638	negative regulation of myeloid cell differentiation
2.14	1.78e-02	GO:0048878	chemical homeostasis
1.52	1.85e-02	GO:0048519	negative regulation of biological process
4.60	1.88e-02	GO:0045637	regulation of myeloid cell differentiation
1.74	2.34e-02	GO:0010033	response to organic substance
20.97	2.58e-02	GO:0015791	polyol transport
2.05	2.71e-02	GO:0045595	regulation of cell differentiation
1.90	2.98e-02	GO:0042592	homeostatic process
1.54	3.21e-02	GO:0048869	cellular developmental process
2.31	3.59e-02	GO:0002684	positive regulation of immune system process

Gene overrepresentation in compartment category:

Enrichment	P-value	GO Accession	GO Term
1.55	3.79e-09	GO:0005886	plasma membrane
1.55	3.95e-09	GO:0071944	cell periphery
1.67	1.27e-05	GO:0044459	plasma membrane part
2.75	1.13e-02	GO:0016323	basolateral plasma membrane
1.49	2.04e-02	GO:0005576	extracellular region
3.00	2.32e-02	GO:0016324	apical plasma membrane
1.63	2.99e-02	GO:0031226	intrinsic to plasma membrane
2.68	3.60e-02	GO:0045177	apical part of cell

Gene overrepresentation in function category:

Enrichment	P-value	GO Accession	GO Term
31.45	4.16e-04	GO:0015168	glycerol transmembrane transporter activity
17.97	1.35e-02	GO:0015166	polyol transmembrane transporter activity
15.73	2.63e-02	GO:0015250	water channel activity
13.98	4.61e-02	GO:0005372	water transmembrane transporter activity