Motif ID: TFEB.p2

Z-value: 1.868


Transcription factors associated with TFEB.p2:

Gene SymbolEntrez IDGene Name
TFEB 7942 transcription factor EB

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TFEBhg19_v1_chr6_-_41673677_41673725-0.151.9e-01Click!


Activity profile for motif TFEB.p2.

activity profile for motif TFEB.p2


Sorted Z-values histogram for motif TFEB.p2

Sorted Z-values for motif TFEB.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFEB.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_11866079 31.284 NM_005957
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr5_+_172483285 29.576 NM_001168393
NM_001168394
NM_153607
C5orf41


chromosome 5 open reading frame 41


chr1_-_11865963 25.312 MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr19_-_41256349 24.596 C19orf54
chromosome 19 open reading frame 54
chr19_-_36545119 23.610 THAP8
THAP domain containing 8
chr19_-_41256371 22.878 C19orf54
chromosome 19 open reading frame 54
chr20_-_44519629 22.585 NM_080749
NEURL2
neuralized homolog 2 (Drosophila)
chrX_-_106960268 21.634 NM_004089
TSC22D3
TSC22 domain family, member 3
chr11_+_67776016 20.742 NM_001161473
ALDH3B1
aldehyde dehydrogenase 3 family, member B1
chr17_-_7137722 20.728 NM_004422
DVL2
dishevelled, dsh homolog 2 (Drosophila)
chrX_-_114797017 19.474


chr3_-_187463474 18.354 NM_001706
BCL6
B-cell CLL/lymphoma 6
chrX_-_106960028 17.632 TSC22D3
TSC22 domain family, member 3
chr12_-_49318663 17.122 NM_001143781
FKBP11
FK506 binding protein 11, 19 kDa
chr5_-_154230157 16.644 C5orf4
chromosome 5 open reading frame 4
chr6_-_33714681 16.619 NM_001142883
NM_054111
IP6K3

inositol hexakisphosphate kinase 3

chr5_-_154230212 16.558 NM_032385
C5orf4
chromosome 5 open reading frame 4
chr12_+_54447660 16.529 NM_153633
HOXC4
HOXC6
homeobox C4
homeobox C6
chr17_-_7137580 15.884 DVL2
dishevelled, dsh homolog 2 (Drosophila)
chr15_-_72668301 15.742 NM_000520
HEXA
hexosaminidase A (alpha polypeptide)
chr19_+_49458129 15.557 BAX
BCL2-associated X protein
chr19_-_5340700 15.482 NM_002850
NM_130853
NM_130854
NM_130855
PTPRS



protein tyrosine phosphatase, receptor type, S



chr10_-_64576123 15.378 NM_000399
NM_001136177
NM_001136179
EGR2


early growth response 2


chr17_-_7137675 15.187 DVL2
dishevelled, dsh homolog 2 (Drosophila)
chr13_-_33002218 15.054 NM_001079691
NM_052818
N4BP2L1

NEDD4 binding protein 2-like 1

chr2_+_85980600 14.775 NM_032827
ATOH8
atonal homolog 8 (Drosophila)
chr3_-_187463227 14.736 BCL6
B-cell CLL/lymphoma 6
chr6_+_138188352 14.479 NM_006290
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr1_+_11866302 14.221 CLCN6
chloride channel 6
chr6_+_160390128 14.220 NM_000876
IGF2R
insulin-like growth factor 2 receptor
chr19_-_10764449 14.053 LOC147727
uncharacterized LOC147727
chr22_-_38577692 14.046 NM_001004426
NM_003560
NM_001199562
PLA2G6


phospholipase A2, group VI (cytosolic, calcium-independent)


chr1_+_32712817 13.834 NM_032648
FAM167B
family with sequence similarity 167, member B
chr1_+_11866240 13.771 CLCN6
chloride channel 6
chr10_-_64576074 13.722 EGR2
early growth response 2
chr1_-_26232890 13.538 NM_001145454
NM_005563
STMN1

stathmin 1

chr13_-_110438896 13.488 NM_003749
IRS2
insulin receptor substrate 2
chr11_-_18343670 13.480 NM_007216
NM_181507
NM_181508
HPS5


Hermansky-Pudlak syndrome 5


chr3_+_112280871 13.454 NM_017945
SLC35A5
solute carrier family 35, member A5
chr19_+_49458151 13.110 BAX
BCL2-associated X protein
chr16_+_30960413 13.004 ORAI3
ORAI calcium release-activated calcium modulator 3
chr16_+_30960434 12.869 ORAI3
ORAI calcium release-activated calcium modulator 3
chr3_+_112280911 12.851 SLC35A5
solute carrier family 35, member A5
chr1_-_186649421 12.659 NM_000963
PTGS2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
chr3_+_23986735 12.638 NM_005126
NR1D2
nuclear receptor subfamily 1, group D, member 2
chr16_+_30960377 12.583 NM_152288
ORAI3
ORAI calcium release-activated calcium modulator 3
chr11_-_71814335 12.473 LAMTOR1
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
chr5_-_154230148 12.409 C5orf4
chromosome 5 open reading frame 4
chr15_-_72668184 12.362 HEXA
hexosaminidase A (alpha polypeptide)
chr20_-_39317875 12.352 NM_005461
MAFB
v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)
chr19_-_36545298 12.090 THAP8
THAP domain containing 8
chr16_+_2570322 11.425 NM_001145815
NM_015944
AMDHD2

amidohydrolase domain containing 2

chr17_-_42200957 11.424 HDAC5
histone deacetylase 5
chr3_+_183353355 11.377 NM_017644
KLHL24
kelch-like 24 (Drosophila)
chr5_-_172198160 11.320 NM_004417
DUSP1
dual specificity phosphatase 1
chr17_-_42201009 11.272 NM_001015053
NM_005474
HDAC5

histone deacetylase 5

chr11_-_71814268 11.162 LAMTOR1
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
chr11_-_71814294 10.952 LAMTOR1
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
chr17_-_47841517 10.791 NM_030802
FAM117A
family with sequence similarity 117, member A
chr20_+_44519924 10.658 CTSA
cathepsin A
chr2_+_220042963 10.649 FAM134A
family with sequence similarity 134, member A
chr13_+_113951461 10.198 NM_005561
LAMP1
lysosomal-associated membrane protein 1
chr12_+_57998600 10.186 NM_178502
DTX3
deltex homolog 3 (Drosophila)
chr19_+_3708358 10.133 TJP3
tight junction protein 3 (zona occludens 3)
chr7_-_47622127 9.875 TNS3
tensin 3
chr1_-_154928595 9.841 PBXIP1
pre-B-cell leukemia homeobox interacting protein 1
chr13_+_52027435 9.792


chr11_-_71814371 9.739 NM_017907
LAMTOR1
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
chr1_-_26232643 9.672 NM_203401
STMN1
stathmin 1
chr2_+_220042901 9.610 NM_024293
FAM134A
family with sequence similarity 134, member A
chr17_+_78075390 9.563 GAA
glucosidase, alpha; acid
chr15_+_72410630 9.378 NM_001172111
NM_145204
SENP8

SUMO/sentrin specific peptidase family member 8

chr16_+_69984809 9.291 NM_182619
CLEC18C
CLEC18A
C-type lectin domain family 18, member C
C-type lectin domain family 18, member A
chr1_-_154928564 9.267 NM_020524
PBXIP1
pre-B-cell leukemia homeobox interacting protein 1
chr3_+_44903376 9.239 NM_144638
TMEM42
transmembrane protein 42
chr17_-_35969401 9.091 NM_001163544
NM_001163545
NM_001163546
NM_001163547
NM_007247
NM_080550
NM_198882
SYNRG






synergin, gamma






chr14_-_20929635 9.062 NM_001100814
NM_144568
TMEM55B

transmembrane protein 55B

chr5_-_131132709 9.008 FNIP1
folliculin interacting protein 1
chr3_-_99594915 8.951 NM_014890
FILIP1L
filamin A interacting protein 1-like
chr7_-_47621741 8.950 NM_022748
TNS3
tensin 3
chr7_-_27183225 8.942 NM_019102
HOXA5
homeobox A5
chr11_+_118938473 8.939 NM_021729
VPS11
vacuolar protein sorting 11 homolog (S. cerevisiae)
chr17_-_47841468 8.907 FAM117A
family with sequence similarity 117, member A
chr22_+_42394728 8.832 NM_152613
WBP2NL
WBP2 N-terminal like
chr17_-_21156577 8.794 NM_152914
C17orf103
chromosome 17 open reading frame 103
chr5_-_131132690 8.778 FNIP1
folliculin interacting protein 1
chr2_+_148778573 8.746 NM_018328
MBD5
methyl-CpG binding domain protein 5
chr1_-_202896315 8.718 KLHL12
kelch-like 12 (Drosophila)
chr20_+_44519965 8.695 CTSA
cathepsin A
chr4_-_39640461 8.679 NM_174921
C4orf34
chromosome 4 open reading frame 34
chr6_-_84937313 8.653 NM_014895
KIAA1009
KIAA1009
chr17_+_78075360 8.598 GAA
glucosidase, alpha; acid
chr2_-_211035377 8.486 C2orf67
chromosome 2 open reading frame 67
chr11_+_1330977 8.405 LOC255512
uncharacterized LOC255512
chr17_-_62915580 8.388 LRRC37A3
leucine rich repeat containing 37, member A3
chr19_+_49458031 8.366 NM_004324
NM_138761
NM_138763
NM_138764
BAX



BCL2-associated X protein



chr2_+_220042948 8.343 FAM134A
family with sequence similarity 134, member A
chr7_+_27225009 8.341 HOXA11-AS1
HOXA11 antisense RNA 1 (non-protein coding)
chr9_+_103115342 8.224


chr2_+_220042986 8.191 FAM134A
family with sequence similarity 134, member A
chr1_+_11866206 8.170 NM_001286
NM_021735
NM_021736
NM_021737
CLCN6



chloride channel 6



chr12_-_110505499 8.155 NM_207435
C12orf76
chromosome 12 open reading frame 76
chr20_+_44520021 8.135 CTSA
cathepsin A
chr17_-_73851377 8.087 NM_012478
WBP2
WW domain binding protein 2
chr17_-_48945338 8.067 NM_001243877
TOB1
transducer of ERBB2, 1
chr6_+_31895401 8.064 C2
complement component 2
chr1_+_181002560 7.937 NM_001194999
NM_001195000
NM_001195035
NM_001531
MR1



major histocompatibility complex, class I-related



chr1_-_202896368 7.923 NM_021633
KLHL12
kelch-like 12 (Drosophila)
chr1_-_204329043 7.896 NM_014935
PLEKHA6
pleckstrin homology domain containing, family A member 6
chr10_+_25305507 7.889 NM_024838
THNSL1
threonine synthase-like 1 (S. cerevisiae)
chr3_+_23987514 7.764 NM_001145425
NR1D2
nuclear receptor subfamily 1, group D, member 2
chr11_+_7535213 7.736 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr11_+_118938528 7.585 VPS11
vacuolar protein sorting 11 homolog (S. cerevisiae)
chr15_-_72668740 7.585 HEXA
hexosaminidase A (alpha polypeptide)
chr10_-_46090191 7.575 NM_001002265
NM_145021
MARCH8

membrane-associated ring finger (C3HC4) 8

chr8_-_9009050 7.474 NM_001201329
PPP1R3B
protein phosphatase 1, regulatory subunit 3B
chr14_-_20929484 7.472 TMEM55B
transmembrane protein 55B
chr5_-_131132642 7.414 FNIP1
folliculin interacting protein 1
chr8_-_143484528 7.342 NM_145003
TSNARE1
t-SNARE domain containing 1
chr6_-_134497069 7.320 NM_001143678
SGK1
serum/glucocorticoid regulated kinase 1
chr11_+_118938515 7.310 VPS11
vacuolar protein sorting 11 homolog (S. cerevisiae)
chr17_+_42977141 7.285 NM_213607
CCDC103
coiled-coil domain containing 103
chr4_+_39184023 7.244 NM_025132
WDR19
WD repeat domain 19
chr8_-_71581354 7.197 LACTB2
lactamase, beta 2
chr13_+_113951537 7.191 LAMP1
lysosomal-associated membrane protein 1
chr11_+_9595309 7.170 WEE1
WEE1 homolog (S. pombe)
chr6_+_43027368 7.073 NM_138343
NM_201521
KLC4

kinesin light chain 4

chr12_-_112450914 6.922 NM_001193453
NM_001193531
NM_138341
LOC728543
TMEM116


uncharacterized LOC728543
transmembrane protein 116


chr10_-_3827418 6.832 NM_001160124
NM_001160125
NM_001300
KLF6


Kruppel-like factor 6


chr11_+_118938530 6.811 VPS11
vacuolar protein sorting 11 homolog (S. cerevisiae)
chr6_+_31982538 6.761 NM_001242823
NM_001252204
NM_007293
NM_001002029
LOC100293534
C4A

C4B
complement C4-B-like
complement component 4A (Rodgers blood group)

complement component 4B (Chido blood group)
chr11_+_9595183 6.736 NM_003390
WEE1
WEE1 homolog (S. pombe)
chr14_-_92572950 6.717 NM_001127696
NM_001127697
NM_001164774
NM_001164776
NM_001164777
NM_001164778
NM_001164779
NM_001164780
NM_001164781
NM_001164782
NM_004993
NM_030660
ATXN3











ataxin 3











chr19_+_14544100 6.716 NM_002741
PKN1
protein kinase N1
chr14_+_103388992 6.713 NM_030943
AMN
amnionless homolog (mouse)
chr3_-_4508952 6.688 SUMF1
sulfatase modifying factor 1
chr5_-_39219578 6.669 NM_001465
NM_199335
FYB

FYN binding protein

chrX_+_101975641 6.648 NM_001142524
NM_001142525
NM_001142526
NM_001142527
NM_001142528
NM_030639
BHLHB9





basic helix-loop-helix domain containing, class B, 9





chr9_+_6757919 6.646 KDM4C
lysine (K)-specific demethylase 4C
chr16_-_28503079 6.638 NM_000086
CLN3
ceroid-lipofuscinosis, neuronal 3
chr3_-_4508955 6.590 NM_001164674
NM_001164675
NM_182760
SUMF1


sulfatase modifying factor 1


chr13_+_113951589 6.584 LAMP1
lysosomal-associated membrane protein 1
chr3_-_4508928 6.582 SUMF1
sulfatase modifying factor 1
chr3_+_113465860 6.554 NM_001690
ATP6V1A
ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
chr1_-_154192882 6.505 C1orf43
chromosome 1 open reading frame 43
chr4_-_23891608 6.492 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr4_+_77135192 6.489 NM_001242936
FAM47E
family with sequence similarity 47, member E
chr8_+_142402108 6.476


chr6_+_31949800 6.458 NM_001242823
NM_001252204
NM_007293
NM_001002029
LOC100293534
C4A

C4B
complement C4-B-like
complement component 4A (Rodgers blood group)

complement component 4B (Chido blood group)
chr22_+_35695872 6.443 TOM1
target of myb1 (chicken)
chr3_-_4508939 6.442 SUMF1
sulfatase modifying factor 1
chr11_+_9595451 6.404 WEE1
WEE1 homolog (S. pombe)
chr15_+_72410724 6.397 SENP8
SUMO/sentrin specific peptidase family member 8
chr5_-_131132715 6.394 NM_001008738
NM_133372
FNIP1

folliculin interacting protein 1

chr19_+_40854529 6.382 PLD3
phospholipase D family, member 3
chr5_-_139944045 6.379 NM_006051
NM_133172
NM_133173
NM_133174
APBB3



amyloid beta (A4) precursor protein-binding, family B, member 3



chr10_+_99344421 6.355 HOGA1
4-hydroxy-2-oxoglutarate aldolase 1
chr10_+_89102474 6.281 LOC677759
uncharacterized LOC677759
chr2_+_187558654 6.264 NM_177454
FAM171B
family with sequence similarity 171, member B
chr15_-_34629941 6.237 NM_001042494
NM_001042496
SLC12A6

solute carrier family 12 (potassium/chloride transporters), member 6

chr12_-_65153148 6.227 GNS
glucosamine (N-acetyl)-6-sulfatase
chr18_+_44497512 6.193 KATNAL2
katanin p60 subunit A-like 2
chrX_+_102883891 6.139 NM_001006639
NM_004780
TCEAL1

transcription elongation factor A (SII)-like 1

chr1_+_183605207 6.130 NM_015149
RGL1
ral guanine nucleotide dissociation stimulator-like 1
chrX_+_10124984 6.121 NM_001830
CLCN4
chloride channel 4
chrX_-_14047958 6.116 NM_001042479
NM_001042480
NM_017856
GEMIN8


gem (nuclear organelle) associated protein 8


chr8_-_95961543 6.086 NM_001135733
NM_033285
TP53INP1

tumor protein p53 inducible nuclear protein 1

chr1_-_24151932 6.076 NM_000191
NM_001166059
HMGCL

3-hydroxymethyl-3-methylglutaryl-CoA lyase

chr19_+_50380681 6.013 NM_001168222
NM_024682
TBC1D17

TBC1 domain family, member 17

chr1_-_155211049 5.962 NM_001171812
NM_000157
GBA

glucosidase, beta, acid

chr11_+_9595429 5.954 WEE1
WEE1 homolog (S. pombe)
chr12_-_65153055 5.933 GNS
glucosamine (N-acetyl)-6-sulfatase
chr7_-_47621635 5.919 TNS3
tensin 3
chr3_+_113465901 5.916 ATP6V1A
ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
chr7_+_36429388 5.829 NM_018685
ANLN
anillin, actin binding protein
chr12_+_96337070 5.806 NM_152435
AMDHD1
amidohydrolase domain containing 1
chr14_-_64970319 5.800 NM_006977
ZBTB25
zinc finger and BTB domain containing 25
chr10_-_3827205 5.790 KLF6
Kruppel-like factor 6
chr3_+_113465910 5.790 ATP6V1A
ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
chr2_-_172967627 5.759 DLX2
distal-less homeobox 2
chr4_-_149363498 5.680 NM_000901
NM_001166104
NR3C2

nuclear receptor subfamily 3, group C, member 2

chr8_-_71581419 5.635 NM_016027
LACTB2
lactamase, beta 2
chr9_-_140444835 5.634 NM_001098537
NM_152286
PNPLA7

patatin-like phospholipase domain containing 7

chr17_+_79935493 5.613 ASPSCR1
alveolar soft part sarcoma chromosome region, candidate 1
chr19_-_40324747 5.605 NM_004714
NM_006483
NM_006484
DYRK1B


dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B


chr7_+_27224163 5.575


chr6_+_123110345 5.557 SMPDL3A
sphingomyelin phosphodiesterase, acid-like 3A
chr12_-_65153182 5.544 GNS
glucosamine (N-acetyl)-6-sulfatase
chr21_-_36421558 5.500 RUNX1
runt-related transcription factor 1
chr17_+_48172508 5.485 NM_001199900
NM_002611
NM_001199899
PDK2


pyruvate dehydrogenase kinase, isozyme 2


chr1_-_24151845 5.479 HMGCL
3-hydroxymethyl-3-methylglutaryl-CoA lyase
chr7_+_99070513 5.456 NM_001013258
NM_213603
ZNF789

zinc finger protein 789

chr9_-_123476578 5.444 NM_001080497
MEGF9
multiple EGF-like-domains 9
chr4_-_103266577 5.341 NM_001135146
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr11_-_66335958 5.328 NM_003793
CTSF
cathepsin F
chr19_+_14544216 5.323 PKN1
protein kinase N1
chr20_-_2821120 5.322 FAM113A
family with sequence similarity 113, member A
chr3_-_40350948 5.236 FLJ33065
uncharacterized LOC440952
chr7_+_99775521 5.181 NM_012447
STAG3
stromal antigen 3
chr1_+_10092990 5.174 NM_001105562
NM_006048
UBE4B

ubiquitination factor E4B


Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
6.74 9.00e-03 GO:0007033 vacuole organization
9.32 1.02e-02 GO:0007040 lysosome organization
14.97 1.66e-02 GO:0032008 positive regulation of TOR signaling cascade
10.78 1.89e-02 GO:0032006 regulation of TOR signaling cascade

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
4.90 2.95e-15 GO:0005773 vacuole
4.82 2.81e-12 GO:0000323 lytic vacuole
4.82 2.81e-12 GO:0005764 lysosome
5.79 8.61e-10 GO:0005774 vacuolar membrane
5.53 2.37e-09 GO:0044437 vacuolar part
5.99 8.58e-08 GO:0005765 lysosomal membrane
1.36 8.21e-06 GO:0044444 cytoplasmic part
1.23 1.16e-04 GO:0043227 membrane-bounded organelle
1.23 2.66e-04 GO:0043231 intracellular membrane-bounded organelle
1.20 3.91e-04 GO:0043226 organelle
1.19 8.07e-04 GO:0043229 intracellular organelle
4.85 1.57e-03 GO:0042470 melanosome
4.85 1.57e-03 GO:0048770 pigment granule
1.21 4.11e-03 GO:0005737 cytoplasm
3.99 5.57e-03 GO:0005770 late endosome
1.13 1.29e-02 GO:0044424 intracellular part
1.13 2.15e-02 GO:0005622 intracellular
1.26 4.30e-02 GO:0044422 organelle part
3.27 4.47e-02 GO:0005769 early endosome
2.17 4.69e-02 GO:0005768 endosome

Nothing significant found in function category.