Motif ID: TFAP4.p2

Z-value: 1.294


Transcription factors associated with TFAP4.p2:

Gene SymbolEntrez IDGene Name
TFAP4 7023 transcription factor AP-4 (activating enhancer binding protein 4)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TFAP4hg19_v1_chr16_-_4323000_4323025-0.123.0e-01Click!


Activity profile for motif TFAP4.p2.

activity profile for motif TFAP4.p2


Sorted Z-values histogram for motif TFAP4.p2

Sorted Z-values for motif TFAP4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_12863406 8.996 NM_017682
BEST2
bestrophin 2
chr1_+_78354199 8.697 NM_001172309
NM_144573
NEXN

nexilin (F actin binding protein)

chr2_+_233271551 8.292 NM_031313
ALPPL2
alkaline phosphatase, placental-like 2
chr17_+_79860071 7.421 NM_148896
NPB
neuropeptide B
chr21_-_15918635 6.471 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr14_-_23284617 6.269 SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr11_-_2018703 6.248 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr19_-_36499583 5.987 NM_001039876
C19orf46
chromosome 19 open reading frame 46
chr20_-_62168663 5.477 NM_005975
PTK6
PTK6 protein tyrosine kinase 6
chr11_+_67777788 5.337 NM_000694
NM_001030010
ALDH3B1

aldehyde dehydrogenase 3 family, member B1

chr11_+_67777795 5.057 ALDH3B1
aldehyde dehydrogenase 3 family, member B1
chr19_-_6720585 5.054 NM_000064
C3
complement component 3
chr11_+_2466171 4.743 NM_000218
KCNQ1
potassium voltage-gated channel, KQT-like subfamily, member 1
chr17_-_39661803 4.622 NM_002274
NM_153490
KRT13

keratin 13

chr7_-_158380360 4.538 NM_002847
NM_130842
NM_130843
PTPRN2


protein tyrosine phosphatase, receptor type, N polypeptide 2


chr20_+_43343523 4.506 WISP2
WNT1 inducible signaling pathway protein 2
chr1_+_20915440 4.387 NM_001785
CDA
cytidine deaminase
chr19_-_47734215 4.384 NM_014417
BBC3
BCL2 binding component 3
chr2_-_96700662 4.362 NM_207328
GPAT2
glycerol-3-phosphate acyltransferase 2, mitochondrial
chr9_-_133814422 4.335 NM_001145106
FIBCD1
fibrinogen C domain containing 1
chr17_-_39092714 4.330 KRT23
keratin 23 (histone deacetylase inducible)
chr6_-_24911194 4.232 NM_014722
FAM65B
family with sequence similarity 65, member B
chr10_+_99332197 4.207 NM_001129981
NM_020349
ANKRD2

ankyrin repeat domain 2 (stretch responsive muscle)

chr11_-_2018334 4.166 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr17_-_19648771 4.135 NM_001135168
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr11_-_2018446 4.122 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr2_+_219187858 4.120 NM_022572
PNKD
paroxysmal nonkinesigenic dyskinesia
chr2_+_233243243 4.111 NM_001632
ALPP
alkaline phosphatase, placental
chr3_+_99357439 4.090 NM_001850
NM_020351
COL8A1

collagen, type VIII, alpha 1

chr15_-_65067696 4.085 NM_194272
RBPMS2
RNA binding protein with multiple splicing 2
chr2_+_219187975 4.059 PNKD
paroxysmal nonkinesigenic dyskinesia
chr6_+_1611544 3.999 FOXC1
forkhead box C1
chr3_-_87040268 3.993 VGLL3
vestigial like 3 (Drosophila)
chr3_-_87040246 3.986 NM_016206
VGLL3
vestigial like 3 (Drosophila)
chr2_+_103236147 3.983 NM_003048
SLC9A2
solute carrier family 9 (sodium/hydrogen exchanger), member 2
chr20_+_13976263 3.940 MACROD2
MACRO domain containing 2
chr11_-_2018568 3.938 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr22_-_50765405 3.937 NM_001001794
FAM116B
family with sequence similarity 116, member B
chr22_+_24577417 3.934 SUSD2
sushi domain containing 2
chr19_-_55658310 3.912 TNNT1
troponin T type 1 (skeletal, slow)
chr14_-_23285011 3.897 NM_001126105
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr2_+_11674241 3.852 NM_014668
GREB1
growth regulation by estrogen in breast cancer 1
chr1_-_935469 3.809 NM_001142467
NM_021170
HES4

hairy and enhancer of split 4 (Drosophila)

chr1_+_110210643 3.793 NM_000848
NM_001142368
GSTM2

glutathione S-transferase mu 2 (muscle)

chr20_+_57267818 3.783 NM_024663
NPEPL1
aminopeptidase-like 1
chrX_-_106960028 3.775 TSC22D3
TSC22 domain family, member 3
chr1_+_226736603 3.742 C1orf95
chromosome 1 open reading frame 95
chr19_+_50191920 3.640 NM_001101340
C19orf76
chromosome 19 open reading frame 76
chr1_-_31230594 3.634 LAPTM5
lysosomal protein transmembrane 5
chr15_-_74495093 3.587 NM_001199042
NM_022369
STRA6

stimulated by retinoic acid gene 6 homolog (mouse)

chr19_+_39574944 3.573 NM_001004318
PAPL
iron/zinc purple acid phosphatase-like protein
chr22_+_24577443 3.438 NM_019601
SUSD2
sushi domain containing 2
chr1_-_1182101 3.428 NM_001014980
FAM132A
family with sequence similarity 132, member A
chr1_+_47489239 3.418 NM_178033
CYP4X1
cytochrome P450, family 4, subfamily X, polypeptide 1
chr11_-_2019070 3.345 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr17_+_4692226 3.306 NM_001014985
GLTPD2
glycolipid transfer protein domain containing 2
chr19_+_2249112 3.299 NM_000479
AMH
anti-Mullerian hormone
chr12_-_117319231 3.289 NM_003806
HRK
harakiri, BCL2 interacting protein (contains only BH3 domain)
chr12_+_52695648 3.248 NM_002284
KRT86
keratin 86
chr9_+_140172273 3.242 NM_017723
C9orf167
chromosome 9 open reading frame 167
chr11_-_2019007 3.180 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr8_+_17354562 3.171 NM_001008539
SLC7A2
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
chr1_-_31230673 3.067 NM_006762
LAPTM5
lysosomal protein transmembrane 5
chrX_-_106959597 3.066 NM_001015881
TSC22D3
TSC22 domain family, member 3
chr14_-_23284565 3.015 SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr20_+_62367945 3.004 NM_017806
LIME1
Lck interacting transmembrane adaptor 1
chr22_-_22089975 3.004 NM_013313
YPEL1
yippee-like 1 (Drosophila)
chr19_+_50192440 2.969 C19orf76
chromosome 19 open reading frame 76
chr17_-_202617 2.950 NM_001190411
NM_001190412
NM_001190413
NM_006987
RPH3AL



rabphilin 3A-like (without C2 domains)



chr10_+_88718287 2.950 NM_003087
SNCG
synuclein, gamma (breast cancer-specific protein 1)
chr20_+_62368035 2.939 LIME1
Lck interacting transmembrane adaptor 1
chr16_+_23194037 2.930 NM_001039
SCNN1G
sodium channel, nonvoltage-gated 1, gamma
chr19_+_20188800 2.929 NM_007138
ZNF90
zinc finger protein 90
chr2_-_27531113 2.911 NM_003353
UCN
urocortin
chr10_-_17496345 2.894 ST8SIA6
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6
chr9_-_139890984 2.876 NM_004669
CLIC3
chloride intracellular channel 3
chr1_-_228135587 2.830 NM_003395
WNT9A
wingless-type MMTV integration site family, member 9A
chr2_+_11680079 2.805 NM_148903
GREB1
growth regulation by estrogen in breast cancer 1
chr1_-_47655723 2.804 NM_005764
PDZK1IP1
PDZK1 interacting protein 1
chr2_+_234621637 2.767 NM_019078
UGT1A5
UDP glucuronosyltransferase 1 family, polypeptide A5
chr14_+_103589711 2.763 TNFAIP2
tumor necrosis factor, alpha-induced protein 2
chr19_-_55791727 2.735 NM_001130106
NM_012267
HSPBP1

HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1

chr22_+_21319417 2.732 NM_001018060
NM_144704
AIFM3

apoptosis-inducing factor, mitochondrion-associated, 3

chr1_-_57044980 2.727 PPAP2B
phosphatidic acid phosphatase type 2B
chr15_+_71839540 2.720 THSD4
thrombospondin, type I, domain containing 4
chr11_+_67810446 2.716 NM_006053
TCIRG1
T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
chr19_+_39989534 2.680 NM_016941
NM_203486
DLL3

delta-like 3 (Drosophila)

chr2_+_11886739 2.678 NM_145693
LPIN1
lipin 1
chr19_+_39989603 2.672 DLL3
delta-like 3 (Drosophila)
chr19_+_49977465 2.664 NM_001204502
NM_001459
FLT3LG

fms-related tyrosine kinase 3 ligand

chr17_+_80186886 2.579 NM_004207
SLC16A3
solute carrier family 16, member 3 (monocarboxylic acid transporter 4)
chr6_-_154831652 2.571 CNKSR3
CNKSR family member 3
chr11_-_2018885 2.551 H19
RPS12
H19, imprinted maternally expressed transcript (non-protein coding)
ribosomal protein S12
chr14_-_95786095 2.541 NM_024734
CLMN
calmin (calponin-like, transmembrane)
chr11_-_65314049 2.537 LTBP3
latent transforming growth factor beta binding protein 3
chr22_-_50964856 2.531 NM_001169109
SCO2
SCO cytochrome oxidase deficient homolog 2 (yeast)
chr15_+_73976537 2.507


chr17_+_77893155 2.490


chr5_+_92920592 2.479 NR2F1
NR2F2
nuclear receptor subfamily 2, group F, member 1
nuclear receptor subfamily 2, group F, member 2
chr6_-_154831788 2.472 CNKSR3
CNKSR family member 3
chr3_+_195447810 2.466 MUC20
mucin 20, cell surface associated
chr3_-_73673978 2.451 NM_015009
PDZRN3
PDZ domain containing ring finger 3
chr17_-_202557 2.445 RPH3AL
rabphilin 3A-like (without C2 domains)
chr5_-_150466696 2.442 NM_001252391
NM_001252392
TNIP1

TNFAIP3 interacting protein 1

chr22_-_50970542 2.436 ODF3B
outer dense fiber of sperm tails 3B
chr1_+_207494816 2.431 NM_000574
NM_001114752
CD55

CD55 molecule, decay accelerating factor for complement (Cromer blood group)

chr11_-_2017822 2.409 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr9_+_92219926 2.407 NM_006705
GADD45G
growth arrest and DNA-damage-inducible, gamma
chr18_-_65183922 2.401 NM_032160
DSEL
dermatan sulfate epimerase-like
chr8_-_141467853 2.399 NM_001160372
TRAPPC9
trafficking protein particle complex 9
chr1_+_207495009 2.395 CD55
CD55 molecule, decay accelerating factor for complement (Cromer blood group)
chr1_-_161059353 2.395 NM_030916
PVRL4
poliovirus receptor-related 4
chr1_-_76081693 2.388 SLC44A5
solute carrier family 44, member 5
chr1_+_207495086 2.371 CD55
CD55 molecule, decay accelerating factor for complement (Cromer blood group)
chr19_-_59084089 2.345 MZF1
myeloid zinc finger 1
chr2_+_233320832 2.299 NM_001631
ALPI
alkaline phosphatase, intestinal
chr19_+_56153417 2.277 NM_016202
NM_001163423
ZNF580

zinc finger protein 580

chr17_+_26711510 2.266 SARM1
sterile alpha and TIR motif containing 1
chr17_+_7905911 2.261 NM_000180
GUCY2D
guanylate cyclase 2D, membrane (retina-specific)
chr19_+_47104389 2.225 CALM3
calmodulin 3 (phosphorylase kinase, delta)
chr14_-_107211131 2.191 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chrX_+_43515441 2.187 MAOA
monoamine oxidase A
chr6_-_167275997 2.173 RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr11_+_48002063 2.168 NM_001098503
NM_002843
PTPRJ

protein tyrosine phosphatase, receptor type, J

chr6_-_167040506 2.164 RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr22_-_18923654 2.152 PRODH
proline dehydrogenase (oxidase) 1
chr11_+_67776016 2.143 NM_001161473
ALDH3B1
aldehyde dehydrogenase 3 family, member B1
chr16_+_5121809 2.143 NM_019109
ALG1
asparagine-linked glycosylation 1, beta-1,4-mannosyltransferase homolog (S. cerevisiae)
chr1_-_47655603 2.142 PDZK1IP1
PDZK1 interacting protein 1
chr17_-_7165788 2.135 CLDN7
claudin 7
chr1_-_57045129 2.122 PPAP2B
phosphatidic acid phosphatase type 2B
chr6_-_35696359 2.110 NM_001145775
FKBP5
FK506 binding protein 5
chr1_-_161059085 2.108 PVRL4
poliovirus receptor-related 4
chr19_+_39989585 2.101 DLL3
delta-like 3 (Drosophila)
chr3_-_196065191 2.093 TM4SF19
transmembrane 4 L six family member 19
chr16_+_28889808 2.092 NM_004320
NM_173201
ATP2A1

ATPase, Ca++ transporting, cardiac muscle, fast twitch 1

chr15_-_74495528 2.092 NM_001142618
STRA6
stimulated by retinoic acid gene 6 homolog (mouse)
chr14_+_64319607 2.081 NM_015180
NM_182914
SYNE2

spectrin repeat containing, nuclear envelope 2

chr7_-_95225802 2.073 NM_002612
PDK4
pyruvate dehydrogenase kinase, isozyme 4
chr6_-_154831704 2.069 NM_173515
CNKSR3
CNKSR family member 3
chr11_+_113930430 2.056 NM_006006
ZBTB16
zinc finger and BTB domain containing 16
chr12_-_52685249 2.044 NM_002281
KRT81
keratin 81
chr16_+_2286467 2.031 NM_001374
DNASE1L2
deoxyribonuclease I-like 2
chr19_-_55628780 2.031 NM_017607
PPP1R12C
protein phosphatase 1, regulatory subunit 12C
chr15_+_41056243 2.027 NM_005258
GCHFR
GTP cyclohydrolase I feedback regulator
chr19_+_54376975 2.023 MYADM
myeloid-associated differentiation marker
chr7_-_107880492 2.020 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr10_-_38691733 2.015 SEPT7L
septin 7-like
chr11_-_124632050 2.010 NM_138961
ESAM
endothelial cell adhesion molecule
chr6_+_160148485 2.001 WTAP
Wilms tumor 1 associated protein
chr1_-_149785235 2.000 NM_001123375
HIST2H3D
histone cluster 2, H3d
chr11_+_113930296 1.997 ZBTB16
zinc finger and BTB domain containing 16
chr1_+_207495070 1.989 CD55
CD55 molecule, decay accelerating factor for complement (Cromer blood group)
chr17_-_76921076 1.988 TIMP2
TIMP metallopeptidase inhibitor 2
chr19_+_48673936 1.976 C19orf68
chromosome 19 open reading frame 68
chr17_-_76124791 1.971 NM_001127198
TMC6
transmembrane channel-like 6
chr16_+_67311412 1.966 NM_015432
PLEKHG4
pleckstrin homology domain containing, family G (with RhoGef domain) member 4
chr8_-_48650683 1.965 CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr19_+_18451365 1.960 NM_017712
PGPEP1
pyroglutamyl-peptidase I
chr3_-_196065243 1.955 NM_001204897
NM_001204898
NM_138461
TM4SF19


transmembrane 4 L six family member 19


chr7_-_156803224 1.951 NM_005515
MNX1
motor neuron and pancreas homeobox 1
chr19_+_18284631 1.943 IFI30
interferon, gamma-inducible protein 30
chr9_+_139846767 1.942 NM_178536
LCN12
lipocalin 12
chr4_+_41362565 1.933 LIMCH1
LIM and calponin homology domains 1
chr19_-_55791446 1.927 HSPBP1
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
chr17_-_79869214 1.908 NM_001184917
NM_002861
PCYT2

phosphate cytidylyltransferase 2, ethanolamine

chr1_+_111770280 1.907 NM_001025197
NM_004000
CHI3L2

chitinase 3-like 2

chr17_-_7166263 1.905 NM_001185023
NM_001307
CLDN7

claudin 7

chr19_-_460995 1.892 NM_012435
SHC2
SHC (Src homology 2 domain containing) transforming protein 2
chr1_+_26348265 1.885 NM_004455
EXTL1
exostoses (multiple)-like 1
chr11_+_68079999 1.883 NM_002335
LRP5
low density lipoprotein receptor-related protein 5
chr19_+_3708358 1.872 TJP3
tight junction protein 3 (zona occludens 3)
chrX_+_38663450 1.865 MID1IP1
MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))
chr17_+_80186281 1.861 NM_001042422
NM_001206950
SLC16A3

solute carrier family 16, member 3 (monocarboxylic acid transporter 4)

chr1_+_150521786 1.848 NM_019032
NM_025008
ADAMTSL4

ADAMTS-like 4

chr11_+_48002120 1.844 PTPRJ
protein tyrosine phosphatase, receptor type, J
chrX_+_38663503 1.842 MID1IP1
MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))
chr17_-_76124767 1.839 TMC6
transmembrane channel-like 6
chr1_-_32827843 1.832 NM_001167676
LOC100128071
uncharacterized LOC100128071
chr1_-_155162633 1.825 NM_001018016
NM_001018017
NM_001044390
NM_001044391
NM_001044392
NM_001044393
NM_001204285
NM_001204286
NM_001204287
NM_001204288
NM_001204289
NM_001204290
NM_001204291
NM_001204292
NM_001204293
NM_001204294
NM_001204295
NM_001204296
NM_001204297
NM_002456
MUC1



















mucin 1, cell surface associated



















chr17_-_76921205 1.817 TIMP2
TIMP metallopeptidase inhibitor 2
chr8_-_133493003 1.807 NM_004519
KCNQ3
potassium voltage-gated channel, KQT-like subfamily, member 3
chrX_-_110513665 1.805 CAPN6
calpain 6
chr22_-_18923963 1.802 NM_001195226
NM_016335
PRODH

proline dehydrogenase (oxidase) 1

chr15_-_74495399 1.801 STRA6
stimulated by retinoic acid gene 6 homolog (mouse)
chr1_-_26680620 1.798 NM_001039775
AIM1L
absent in melanoma 1-like
chr2_-_207082626 1.795 NM_001098199
NM_005279
GPR1

G protein-coupled receptor 1

chr3_+_195447751 1.784 NM_152673
MUC20
mucin 20, cell surface associated
chr14_+_95047730 1.780 NM_000624
SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr6_-_167040659 1.779 RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr1_-_935352 1.777 HES4
hairy and enhancer of split 4 (Drosophila)
chr2_+_47168362 1.772 TTC7A
tetratricopeptide repeat domain 7A
chr1_-_1310522 1.769 AURKAIP1
aurora kinase A interacting protein 1
chr20_-_14318200 1.766 NM_013281
NM_198391
FLRT3

fibronectin leucine rich transmembrane protein 3

chr17_-_43510279 1.738 NM_174919
ARHGAP27
Rho GTPase activating protein 27
chr17_+_81037504 1.723 NM_001004431
METRNL
meteorin, glial cell differentiation regulator-like
chr11_+_1861431 1.719 NM_001145841
TNNI2
troponin I type 2 (skeletal, fast)
chr11_+_67806454 1.710 NM_006019
TCIRG1
T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
chr15_+_79724857 1.702 NM_015206
KIAA1024
KIAA1024
chr19_+_6464259 1.699 NM_139161
NM_174881
CRB3

crumbs homolog 3 (Drosophila)


Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
36.40 9.79e-03 GO:0004035 alkaline phosphatase activity