Motif ID: TCF4_dimer.p2

Z-value: 1.831


Transcription factors associated with TCF4_dimer.p2:

Gene SymbolEntrez IDGene Name
TCF4 6925 transcription factor 4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TCF4hg19_v1_chr18_-_53071225_530712250.593.5e-08Click!


Activity profile for motif TCF4_dimer.p2.

activity profile for motif TCF4_dimer.p2


Sorted Z-values histogram for motif TCF4_dimer.p2

Sorted Z-values for motif TCF4_dimer.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TCF4_dimer.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_40367539 22.843 NM_001033081
NM_001033082
NM_005376
MYCL1


v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)


chr2_+_219745243 19.686 NM_025216
WNT10A
wingless-type MMTV integration site family, member 10A
chr4_+_41258941 19.422 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr11_+_118401755 17.248 NM_001144034
NM_001144035
NM_001144036
NM_001144037
NM_001144038
NM_032780
TMEM25





transmembrane protein 25





chr11_+_118401873 15.359 TMEM25
transmembrane protein 25
chr22_-_21905372 14.839 NM_001128635
RIMBP3B
RIMS binding protein 3B
chr4_-_77819001 14.341 NM_001029870
ANKRD56
ankyrin repeat domain 56
chr17_+_7452374 13.827 NM_172089
NM_003809
TNFSF12-TNFSF13
TNFSF12
TNFSF12-TNFSF13 readthrough
tumor necrosis factor (ligand) superfamily, member 12
chr15_-_44487237 13.681 NM_032892
FRMD5
FERM domain containing 5
chr3_-_99833348 13.421 NM_001042459
NM_182909
FILIP1L

filamin A interacting protein 1-like

chr3_+_186648515 13.112 ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr19_+_36359346 13.048 NM_001024807
NM_005166
APLP1

amyloid beta (A4) precursor-like protein 1

chr20_+_44098392 12.236 NM_006103
WFDC2
WAP four-disulfide core domain 2
chr4_-_57976550 12.121 NM_001253835
NM_001553
IGFBP7

insulin-like growth factor binding protein 7

chr15_-_44487468 11.969 FRMD5
FERM domain containing 5
chr3_-_121740968 11.951 NM_001199799
NM_001199800
NM_175924
ILDR1


immunoglobulin-like domain containing receptor 1


chr17_-_8702438 11.904 NM_152599
MFSD6L
major facilitator superfamily domain containing 6-like
chr22_+_21738039 11.834 NM_001128635
RIMBP3B
RIMS binding protein 3B
chr4_-_57976516 11.575 IGFBP7
insulin-like growth factor binding protein 7
chr15_-_48470453 11.562 NM_016132
MYEF2
myelin expression factor 2
chr6_-_89827605 11.319 NM_080743
SRSF12
serine/arginine-rich splicing factor 12
chr8_+_72756218 11.172 LOC100132891
uncharacterized LOC100132891
chr1_-_151345156 11.048 NM_003944
SELENBP1
selenium binding protein 1
chr14_+_77228940 11.017 VASH1
vasohibin 1
chr19_-_47137938 10.949 NM_033258
GNG8
guanine nucleotide binding protein (G protein), gamma 8
chr11_-_125366048 10.947 NM_005103
NM_022549
FEZ1

fasciculation and elongation protein zeta 1 (zygin I)

chr9_+_17578952 10.810 NM_003026
SH3GL2
SH3-domain GRB2-like 2
chr22_-_20137430 10.707 NM_001243537
LOC388849
uncharacterized LOC388849
chr15_+_74218962 10.480 LOXL1
lysyl oxidase-like 1
chr14_-_23821423 10.394 NM_020372
SLC22A17
solute carrier family 22, member 17
chr1_-_110052285 9.977 NM_020703
AMIGO1
adhesion molecule with Ig-like domain 1
chr16_+_330605 9.899 NM_001176
ARHGDIG
Rho GDP dissociation inhibitor (GDI) gamma
chr5_+_156887204 9.838 NIPAL4
NIPA-like domain containing 4
chr15_-_76030958 9.360 DNM1P35
DNM1 pseudogene 35
chr5_-_132948222 9.224 NM_015082
FSTL4
follistatin-like 4
chr4_-_57976355 9.068 IGFBP7
insulin-like growth factor binding protein 7
chr1_-_108507474 9.003 NM_006113
VAV3
vav 3 guanine nucleotide exchange factor
chr9_-_97401588 8.661 FBP1
fructose-1,6-bisphosphatase 1
chr8_+_72756335 8.554


chr19_-_18548788 8.540 NM_001170939
ISYNA1
inositol-3-phosphate synthase 1
chr19_-_7701852 8.527


chr8_-_124553253 8.501 FBXO32
F-box protein 32
chr5_+_137801178 8.429 NM_001964
EGR1
early growth response 1
chr10_-_98480174 8.405 NM_152309
PIK3AP1
phosphoinositide-3-kinase adaptor protein 1
chr19_-_51456159 8.336 NM_001077491
NM_001077492
NM_012427
KLK5


kallikrein-related peptidase 5


chr11_+_73358593 8.249 NM_001130034
NM_001130035
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr8_+_99076749 8.007 NM_001170806
NM_173549
C8orf47

chromosome 8 open reading frame 47

chr16_-_89043215 7.999 NM_005187
CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr17_+_67410825 7.899 NM_002758
MAP2K6
mitogen-activated protein kinase kinase 6
chr15_-_48470319 7.899 MYEF2
myelin expression factor 2
chr19_+_41699140 7.612 CYP2S1
cytochrome P450, family 2, subfamily S, polypeptide 1
chr5_-_136834231 7.562 SPOCK1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
chr5_+_132149022 7.561 NM_175873
ANKRD43
ankyrin repeat domain 43
chr6_+_46097700 7.538 NM_014936
ENPP4
ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
chr5_-_102898450 7.472 NM_031438
NUDT12
nudix (nucleoside diphosphate linked moiety X)-type motif 12
chr10_-_90967048 7.431 NM_003956
CH25H
cholesterol 25-hydroxylase
chr9_+_35673852 7.419 NM_001216
CA9
carbonic anhydrase IX
chr15_+_74218794 7.384 LOXL1
lysyl oxidase-like 1
chr5_+_137774632 7.360 NM_016606
REEP2
receptor accessory protein 2
chr5_-_136834418 7.359 SPOCK1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
chr17_-_27949814 7.309 CORO6
coronin 6
chrX_-_107018889 7.225 TSC22D3
TSC22 domain family, member 3
chr9_+_140033588 7.220 NM_000832
NM_001185090
NM_001185091
NM_007327
NM_021569
GRIN1




glutamate receptor, ionotropic, N-methyl D-aspartate 1




chr4_-_186733372 7.205 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr18_+_10454620 7.204 NM_153000
APCDD1
adenomatosis polyposis coli down-regulated 1
chr16_+_82660390 7.110 NM_001220488
NM_001220489
NM_001220490
NM_001220491
NM_001220492
NM_001257
CDH13





cadherin 13, H-cadherin (heart)





chr12_+_130822590 7.100 PIWIL1
piwi-like 1 (Drosophila)
chr5_-_1112106 7.089 NM_006598
SLC12A7
solute carrier family 12 (potassium/chloride transporters), member 7
chr22_-_31686707 7.038 PIK3IP1
phosphoinositide-3-kinase interacting protein 1
chr9_+_90112754 7.004 NM_004938
DAPK1
death-associated protein kinase 1
chr21_-_42219038 6.992 NM_001389
DSCAM
Down syndrome cell adhesion molecule
chr10_-_62703822 6.969 NM_001242359
NM_014836
RHOBTB1

Rho-related BTB domain containing 1

chr15_+_74218786 6.959 NM_005576
LOXL1
lysyl oxidase-like 1
chr9_-_97401746 6.952 FBP1
fructose-1,6-bisphosphatase 1
chr8_-_79717540 6.929 NM_000880
NM_001199886
NM_001199887
NM_001199888
IL7



interleukin 7



chr12_+_6419601 6.919 NM_018173
PLEKHG6
pleckstrin homology domain containing, family G (with RhoGef domain) member 6
chr1_+_154301219 6.885 ATP8B2
ATPase, class I, type 8B, member 2
chr7_+_156803599 6.880 LOC645249
uncharacterized LOC645249
chrX_-_84634742 6.871 NM_024921
POF1B
premature ovarian failure, 1B
chr19_-_40324747 6.832 NM_004714
NM_006483
NM_006484
DYRK1B


dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B


chr7_-_73184535 6.781 NM_001306
CLDN3
claudin 3
chr3_-_64211111 6.711 NM_198859
PRICKLE2
prickle homolog 2 (Drosophila)
chr6_+_5085719 6.692 NM_001145115
PPP1R3G
protein phosphatase 1, regulatory subunit 3G
chr20_+_45523247 6.542 NM_005244
NM_172110
EYA2

eyes absent homolog 2 (Drosophila)

chr17_+_60704747 6.542 NM_006039
MRC2
mannose receptor, C type 2
chr6_+_46097818 6.511 ENPP4
ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
chr9_-_97401833 6.481 NM_000507
FBP1
fructose-1,6-bisphosphatase 1
chr16_-_77468930 6.467 NM_199355
ADAMTS18
ADAM metallopeptidase with thrombospondin type 1 motif, 18
chr13_-_20806533 6.464 NM_001110219
NM_001110220
NM_001110221
GJB6


gap junction protein, beta 6, 30kDa


chrX_-_84634396 6.419 POF1B
premature ovarian failure, 1B
chr9_+_33795558 6.408 NM_002771
PRSS3
protease, serine, 3
chr2_-_160761192 6.368 LY75-CD302
LY75
LY75-CD302 readthrough
lymphocyte antigen 75
chr2_+_173600519 6.328 NM_007023
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr8_-_17658711 6.308


chr20_+_42839599 6.272 LOC100505783
uncharacterized LOC100505783
chr5_+_156887026 6.199 NM_001099287
NM_001172292
NIPAL4

NIPA-like domain containing 4

chr12_-_49259549 6.196 NM_014470
RND1
Rho family GTPase 1
chr15_+_47476225 6.179 NM_001198999
SEMA6D
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr15_+_75118950 6.157 NM_001030005
CPLX3
complexin 3
chr1_+_154300275 6.153 NM_020452
ATP8B2
ATPase, class I, type 8B, member 2
chrX_+_134555867 6.117 LINC00086
long intergenic non-protein coding RNA 86
chr19_+_36347809 6.115 NM_032123
NM_199179
NM_199180
KIRREL2


kin of IRRE like 2 (Drosophila)


chr19_-_18548971 6.099 NM_001170938
NM_016368
ISYNA1

inositol-3-phosphate synthase 1

chr20_+_44637539 6.094 NM_004994
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr5_-_151066492 6.092 NM_003118
SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chr1_+_116380404 6.021 NHLH2
nescient helix loop helix 2
chr16_-_31214054 6.007 NM_013258
NM_145182
PYCARD

PYD and CARD domain containing

chr17_+_60705042 6.001 MRC2
mannose receptor, C type 2
chrX_-_50557019 5.996 NM_020717
SHROOM4
shroom family member 4
chr6_+_87865261 5.895 NM_015021
ZNF292
zinc finger protein 292
chr6_-_110679474 5.883 NM_001123364
C6orf186
chromosome 6 open reading frame 186
chr5_+_137203559 5.841 MYOT
myotilin
chr17_-_21156577 5.840 NM_152914
C17orf103
chromosome 17 open reading frame 103
chrX_-_107019001 5.828 NM_198057
TSC22D3
TSC22 domain family, member 3
chr12_-_91348950 5.816 NM_152638
C12orf12
chromosome 12 open reading frame 12
chr19_+_41699076 5.809 NM_030622
CYP2S1
cytochrome P450, family 2, subfamily S, polypeptide 1
chr16_+_1031807 5.806 NM_014587
SOX8
SRY (sex determining region Y)-box 8
chr16_+_83932729 5.792 NM_012213
MLYCD
malonyl-CoA decarboxylase
chr13_+_78271820 5.786 NM_001242868
SLAIN1
SLAIN motif family, member 1
chr5_+_137774897 5.779 REEP2
receptor accessory protein 2
chr20_+_45523505 5.764 EYA2
eyes absent homolog 2 (Drosophila)
chr8_-_124553448 5.727 NM_001242463
NM_058229
FBXO32

F-box protein 32

chr17_-_80797889 5.727 NM_024702
ZNF750
zinc finger protein 750
chr14_+_72398816 5.649 NM_001204423
RGS6
regulator of G-protein signaling 6
chr19_-_12886263 5.627 HOOK2
hook homolog 2 (Drosophila)
chr16_-_54318889 5.611 IRX3
iroquois homeobox 3
chr15_-_40401041 5.607 NM_001003940
BMF
Bcl2 modifying factor
chr5_-_137071703 5.603 NM_017415
KLHL3
kelch-like 3 (Drosophila)
chr2_+_231902194 5.574 NM_001144994
C2orf72
chromosome 2 open reading frame 72
chr18_+_10454542 5.548 APCDD1
adenomatosis polyposis coli down-regulated 1
chr15_+_25227140 5.544 SNRPN
small nuclear ribonucleoprotein polypeptide N
chr15_-_32162896 5.541 OTUD7A
OTU domain containing 7A
chr5_+_110559647 5.527 NM_001744
CAMK4
calcium/calmodulin-dependent protein kinase IV
chr6_-_32160637 5.496 GPSM3
G-protein signaling modulator 3
chr17_+_47653176 5.482 NM_007225
NXPH3
neurexophilin 3
chr11_-_47470687 5.471 NM_005055
NM_032645
RAPSN

receptor-associated protein of the synapse

chr7_-_79082870 5.470 NM_012301
MAGI2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr19_-_46974663 5.465 PNMAL1
PNMA-like 1
chr5_+_59784004 5.464 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr8_-_139509064 5.461 NM_015912
FAM135B
family with sequence similarity 135, member B
chr12_-_57351381 5.452 NM_003708
RDH16
retinol dehydrogenase 16 (all-trans)
chr11_+_111789658 5.425 C11orf52
chromosome 11 open reading frame 52
chr20_+_45523523 5.422 EYA2
eyes absent homolog 2 (Drosophila)
chr16_-_31214003 5.421 PYCARD
PYD and CARD domain containing
chr2_-_96781887 5.416 NM_000682
ADRA2B
adrenergic, alpha-2B-, receptor
chr14_+_102027687 5.401 NM_001362
DIO3
deiodinase, iodothyronine, type III
chr5_+_137203544 5.397 NM_001135940
NM_006790
MYOT

myotilin

chr16_-_31161381 5.391 NM_173502
PRSS36
protease, serine, 36
chrX_-_84634664 5.384 POF1B
premature ovarian failure, 1B
chr5_-_137071462 5.384 KLHL3
kelch-like 3 (Drosophila)
chr16_+_1032063 5.379 SOX8
SRY (sex determining region Y)-box 8
chr5_-_168727715 5.374 NM_003062
SLIT3
slit homolog 3 (Drosophila)
chr5_-_151066445 5.323 SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chr5_-_132948195 5.321 FSTL4
follistatin-like 4
chr14_+_24836144 5.299 NM_001136022
NM_001198967
NFATC4

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4

chr2_+_37571752 5.266 NM_012413
QPCT
glutaminyl-peptide cyclotransferase
chr11_-_119187811 5.265 NM_006500
MCAM
melanoma cell adhesion molecule
chr3_+_186330844 5.237 NM_001622
AHSG
alpha-2-HS-glycoprotein
chr19_-_18548118 5.206 NM_001253389
ISYNA1
inositol-3-phosphate synthase 1
chr12_+_41086189 5.196 NM_001843
NM_175038
CNTN1

contactin 1

chr14_-_20929635 5.192 NM_001100814
NM_144568
TMEM55B

transmembrane protein 55B

chr1_-_2461683 5.189 NM_001010926
HES5
hairy and enhancer of split 5 (Drosophila)
chr19_-_35981345 5.160 NM_001244847
NM_207392
KRTDAP

keratinocyte differentiation-associated protein

chr16_-_14788429 5.155 NM_003561
PLA2G10
phospholipase A2, group X
chr11_+_1330977 5.148 LOC255512
uncharacterized LOC255512
chr19_-_39264144 5.135 NM_002307
LGALS7
LGALS7B
lectin, galactoside-binding, soluble, 7
lectin, galactoside-binding, soluble, 7B
chr4_+_184826427 5.120 NM_020225
STOX2
storkhead box 2
chr11_+_111789600 5.120 NM_080659
C11orf52
chromosome 11 open reading frame 52
chr9_-_131872907 5.093 NM_000755
CRAT
carnitine O-acetyltransferase
chr6_+_124125068 5.092 NM_001040214
NM_153355
NKAIN2

Na+/K+ transporting ATPase interacting 2

chr19_+_5904842 5.091 NM_001017921
VMAC
vimentin-type intermediate filament associated coiled-coil protein
chr17_-_78450247 5.074 NM_002522
NPTX1
neuronal pentraxin I
chr19_-_2308155 5.036 NM_001101391
LINGO3
leucine rich repeat and Ig domain containing 3
chr4_-_25032306 5.033 NM_018176
LGI2
leucine-rich repeat LGI family, member 2
chr5_+_140474198 5.027 NM_018936
PCDHB2
protocadherin beta 2
chr19_-_4535202 5.026 NM_001013706
PLIN5
perilipin 5
chr9_+_131870105 4.978


chr1_-_6662681 4.949 KLHL21
kelch-like 21 (Drosophila)
chr19_-_1401474 4.924 NM_000156
NM_138924
GAMT

guanidinoacetate N-methyltransferase

chr9_-_131872782 4.885 CRAT
carnitine O-acetyltransferase
chr16_-_4588738 4.873 NM_001199055
NM_001199056
NM_013399
C16orf5


chromosome 16 open reading frame 5


chr11_+_86511490 4.873 NM_007173
PRSS23
protease, serine, 23
chr20_+_49348050 4.871 NM_032521
PARD6B
par-6 partitioning defective 6 homolog beta (C. elegans)
chrX_-_152939256 4.871 PNCK
pregnancy up-regulated non-ubiquitously expressed CaM kinase
chr7_-_3083346 4.862 NM_032415
CARD11
caspase recruitment domain family, member 11
chr1_+_13910251 4.843 NM_006474
NM_198389
PDPN

podoplanin

chr8_-_110656887 4.831 SYBU
syntabulin (syntaxin-interacting)
chr4_+_41258909 4.813 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr19_-_12267528 4.809 NM_145233
ZNF625-ZNF20
ZNF625
ZNF625-ZNF20 readthrough
zinc finger protein 625
chr3_-_53880403 4.804 NM_018397
CHDH
choline dehydrogenase
chr7_-_139168408 4.801 NM_198508
KLRG2
killer cell lectin-like receptor subfamily G, member 2
chr19_-_7698569 4.794 NM_174895
PCP2
Purkinje cell protein 2
chr9_-_89562103 4.794 NM_002048
GAS1
growth arrest-specific 1
chr19_+_35773409 4.788 NM_021175
HAMP
hepcidin antimicrobial peptide
chr13_-_36788665 4.787 NM_017826
SOHLH2
spermatogenesis and oogenesis specific basic helix-loop-helix 2
chr2_-_178417434 4.782 NM_152517
TTC30B
tetratricopeptide repeat domain 30B
chr1_+_16375283 4.779 NM_001165945
CLCNKB
chloride channel Kb
chr1_-_166944504 4.764 NM_199351
ILDR2
immunoglobulin-like domain containing receptor 2
chr12_+_56624500 4.757 NM_001135195
SLC39A5
solute carrier family 39 (metal ion transporter), member 5
chr15_+_57668702 4.756 NM_001252335
NM_032866
CGNL1

cingulin-like 1


Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.52 1.62e-20 GO:0048856 anatomical structure development
1.49 5.06e-20 GO:0007275 multicellular organismal development
1.54 4.33e-19 GO:0048731 system development
1.44 7.38e-19 GO:0032502 developmental process
1.34 3.67e-17 GO:0032501 multicellular organismal process
1.72 1.83e-15 GO:0007399 nervous system development
1.54 3.92e-11 GO:0048513 organ development
1.58 1.39e-09 GO:0009653 anatomical structure morphogenesis
1.47 5.65e-09 GO:0030154 cell differentiation
1.44 3.45e-08 GO:0048869 cellular developmental process
1.79 2.57e-07 GO:0030182 neuron differentiation
1.65 8.43e-07 GO:0048468 cell development
1.66 1.14e-06 GO:0006811 ion transport
1.63 2.98e-06 GO:0022008 neurogenesis
1.64 7.18e-06 GO:0048699 generation of neurons
1.85 1.24e-05 GO:0019226 transmission of nerve impulse
1.85 1.24e-05 GO:0035637 multicellular organismal signaling
1.78 1.88e-05 GO:0048666 neuron development
1.65 3.70e-05 GO:0007267 cell-cell signaling
1.49 3.71e-05 GO:0051239 regulation of multicellular organismal process
1.88 4.23e-05 GO:0007268 synaptic transmission
1.74 4.88e-05 GO:0009887 organ morphogenesis
1.78 1.10e-04 GO:0007417 central nervous system development
1.63 1.13e-03 GO:0030030 cell projection organization
1.49 1.49e-03 GO:0007154 cell communication
1.66 1.56e-03 GO:0006812 cation transport
1.56 1.98e-03 GO:0007155 cell adhesion
1.56 1.98e-03 GO:0022610 biological adhesion
1.69 3.02e-03 GO:0000904 cell morphogenesis involved in differentiation
1.74 3.45e-03 GO:0048667 cell morphogenesis involved in neuron differentiation
1.68 5.26e-03 GO:0030001 metal ion transport
1.83 5.73e-03 GO:0044057 regulation of system process
1.67 6.92e-03 GO:0031175 neuron projection development
1.49 7.21e-03 GO:0040011 locomotion
3.45 7.97e-03 GO:0007422 peripheral nervous system development
1.58 1.11e-02 GO:0032989 cellular component morphogenesis
1.71 1.30e-02 GO:0007409 axonogenesis
1.69 1.32e-02 GO:0048812 neuron projection morphogenesis
1.12 1.50e-02 GO:0065007 biological regulation
1.46 1.89e-02 GO:0050793 regulation of developmental process
1.75 1.96e-02 GO:0007420 brain development
1.58 1.97e-02 GO:0000902 cell morphogenesis
1.84 2.76e-02 GO:0007423 sensory organ development
1.76 4.80e-02 GO:0051046 regulation of secretion

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.59 4.94e-17 GO:0005576 extracellular region
1.77 4.83e-13 GO:0044421 extracellular region part
1.33 8.89e-13 GO:0005886 plasma membrane
1.49 1.36e-12 GO:0044459 plasma membrane part
1.32 4.61e-12 GO:0071944 cell periphery
2.20 3.03e-10 GO:0031012 extracellular matrix
2.24 4.93e-09 GO:0005578 proteinaceous extracellular matrix
1.74 8.08e-09 GO:0005615 extracellular space
2.41 1.35e-07 GO:0034702 ion channel complex
1.52 2.20e-07 GO:0031226 intrinsic to plasma membrane
1.53 2.25e-07 GO:0005887 integral to plasma membrane
2.30 1.02e-03 GO:0034703 cation channel complex
1.12 2.38e-03 GO:0016020 membrane
1.51 1.11e-02 GO:0030054 cell junction
1.62 1.41e-02 GO:0045202 synapse
1.14 1.79e-02 GO:0031224 intrinsic to membrane
1.12 2.40e-02 GO:0044425 membrane part
1.68 4.44e-02 GO:0044456 synapse part

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
2.03 7.25e-08 GO:0022838 substrate-specific channel activity
2.01 7.62e-08 GO:0022803 passive transmembrane transporter activity
1.66 1.32e-07 GO:0022891 substrate-specific transmembrane transporter activity
1.72 1.49e-07 GO:0015075 ion transmembrane transporter activity
1.99 1.58e-07 GO:0015267 channel activity
1.62 2.64e-07 GO:0022857 transmembrane transporter activity
1.60 3.67e-07 GO:0001071 nucleic acid binding transcription factor activity
1.60 3.67e-07 GO:0003700 sequence-specific DNA binding transcription factor activity
1.97 1.00e-06 GO:0005216 ion channel activity
1.70 2.12e-06 GO:0043565 sequence-specific DNA binding
2.03 7.91e-06 GO:0022836 gated channel activity
2.11 8.26e-06 GO:0005261 cation channel activity
1.53 1.17e-05 GO:0022892 substrate-specific transporter activity
1.47 2.69e-05 GO:0005215 transporter activity
3.08 3.46e-05 GO:0005201 extracellular matrix structural constituent
1.70 4.60e-05 GO:0008324 cation transmembrane transporter activity
1.57 9.28e-04 GO:0005509 calcium ion binding
2.17 5.16e-03 GO:0008509 anion transmembrane transporter activity
2.19 6.09e-03 GO:0022843 voltage-gated cation channel activity
2.00 7.89e-03 GO:0005244 voltage-gated ion channel activity
2.00 7.89e-03 GO:0022832 voltage-gated channel activity
1.40 1.08e-02 GO:0030528 transcription regulator activity