Motif ID: STAT2,4,6.p2

Z-value: 1.665


Transcription factors associated with STAT2,4,6.p2:

Gene SymbolEntrez IDGene Name
STAT2 6773 signal transducer and activator of transcription 2, 113kDa
STAT4 6775 signal transducer and activator of transcription 4
STAT6 6778 signal transducer and activator of transcription 6, interleukin-4 induced

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
STAT6hg19_v1_chr12_-_57505176_575052190.702.5e-12Click!
STAT2hg19_v1_chr12_-_56753856_567539110.681.3e-11Click!
STAT4hg19_v1_chr2_-_192016293_1920163210.456.1e-05Click!


Activity profile for motif STAT2,4,6.p2.

activity profile for motif STAT2,4,6.p2


Sorted Z-values histogram for motif STAT2,4,6.p2

Sorted Z-values for motif STAT2,4,6.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of STAT2,4,6.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_119187811 20.093 NM_006500
MCAM
melanoma cell adhesion molecule
chr5_-_102898450 17.241 NM_031438
NUDT12
nudix (nucleoside diphosphate linked moiety X)-type motif 12
chr12_+_133656984 16.405 NM_003440
ZNF140
zinc finger protein 140
chr19_+_37407230 15.476 NM_001204835
NM_001204836
NM_001204837
NM_001204838
NM_001204839
NM_198539
ZNF568





zinc finger protein 568





chr12_+_133657478 14.126 ZNF140
zinc finger protein 140
chr3_-_187463227 13.758 BCL6
B-cell CLL/lymphoma 6
chr17_-_46655544 13.451 NM_024015
HOXB4
homeobox B4
chr19_-_37407079 13.301 NM_001037232
ZNF829
zinc finger protein 829
chr12_-_7245006 13.245 NM_001733
C1R
complement component 1, r subcomponent
chr19_-_44952630 12.413 NM_014518
ZNF229
zinc finger protein 229
chrX_+_102632108 12.283 NM_014380
NGFRAP1
nerve growth factor receptor (TNFRSF16) associated protein 1
chr19_+_15218141 12.169 NM_033025
SYDE1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr17_+_1646129 12.071 NM_000934
NM_001165921
SERPINF2

serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2

chr1_+_201979689 11.749 NM_001114309
NM_004433
ELF3

E74-like factor 3 (ets domain transcription factor, epithelial-specific )

chr19_+_45418063 11.452 APOC1
apolipoprotein C-I
chr12_-_7245048 11.237 C1R
complement component 1, r subcomponent
chr17_+_38171613 11.150 NM_000759
NM_001178147
NM_172219
NM_172220
CSF3



colony stimulating factor 3 (granulocyte)



chr9_-_89562103 11.040 NM_002048
GAS1
growth arrest-specific 1
chr19_-_37406918 10.937 NM_001171979
ZNF829
zinc finger protein 829
chr5_-_151066492 10.729 NM_003118
SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chr10_+_95848811 10.400 NM_001165979
PLCE1
phospholipase C, epsilon 1
chr5_+_140474198 10.137 NM_018936
PCDHB2
protocadherin beta 2
chr22_-_31688329 10.110 NM_001135911
NM_052880
PIK3IP1

phosphoinositide-3-kinase interacting protein 1

chr17_-_76356153 9.866 NM_003955
SOCS3
suppressor of cytokine signaling 3
chr5_-_151066445 9.704 SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chr19_+_35168558 9.594 NM_001012320
NM_018443
ZNF302

zinc finger protein 302

chr3_-_187463474 9.491 NM_001706
BCL6
B-cell CLL/lymphoma 6
chr17_+_1646290 9.481 NM_001165920
SERPINF2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr8_-_124665165 9.404 NM_001081675
KLHL38
kelch-like 38 (Drosophila)
chr10_+_75673346 9.396 PLAU
plasminogen activator, urokinase
chr5_+_172483285 9.149 NM_001168393
NM_001168394
NM_153607
C5orf41


chromosome 5 open reading frame 41


chr4_+_41258941 9.123 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr17_-_8274852 9.012 NM_213597
KRBA2
KRAB-A domain containing 2
chr19_+_44488331 8.902 NM_003445
NM_198089
ZNF155

zinc finger protein 155

chr1_+_201979747 8.815 ELF3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr17_+_1646143 8.317 SERPINF2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr3_-_48632592 8.308 NM_000094
COL7A1
collagen, type VII, alpha 1
chr7_-_83278478 8.248 NM_012431
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr12_+_133657439 7.740 ZNF140
zinc finger protein 140
chr9_+_100069909 7.739 NM_020893
C9orf174
chromosome 9 open reading frame 174
chr3_-_160822625 7.715 NM_033169
NM_001038628
NM_003781
NM_033167
NM_033168
B3GALNT1




beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)




chr11_+_43963809 7.667 NM_001145033
C11orf96
chromosome 11 open reading frame 96
chr19_-_37958338 7.665 NM_152484
ZNF569
zinc finger protein 569
chr4_-_186697065 7.660 NM_001145673
SORBS2
sorbin and SH3 domain containing 2
chr17_+_7452374 7.341 NM_172089
NM_003809
TNFSF12-TNFSF13
TNFSF12
TNFSF12-TNFSF13 readthrough
tumor necrosis factor (ligand) superfamily, member 12
chrX_-_106960268 7.317 NM_004089
TSC22D3
TSC22 domain family, member 3
chr1_+_149871154 7.306 NM_016074
BOLA1
bolA homolog 1 (E. coli)
chr2_-_145277879 7.197 NM_001171653
NM_014795
ZEB2

zinc finger E-box binding homeobox 2

chr2_-_145277568 7.142 ZEB2
zinc finger E-box binding homeobox 2
chr6_+_19837599 7.044 NM_001546
ID4
inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
chr15_-_45493372 6.982 NM_138356
SHF
Src homology 2 domain containing F
chr5_-_111092865 6.750 C5orf13
chromosome 5 open reading frame 13
chr4_+_41258909 6.726 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr12_+_12938540 6.622 NM_030817
APOLD1
apolipoprotein L domain containing 1
chr11_-_12030128 6.566 NM_001018057
DKK3
dickkopf 3 homolog (Xenopus laevis)
chr19_-_40324747 6.388 NM_004714
NM_006483
NM_006484
DYRK1B


dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B


chr19_-_44405934 6.343 LOC100505715
uncharacterized LOC100505715
chr4_+_74606222 6.288 NM_000584
IL8
interleukin 8
chr9_+_33795558 6.183 NM_002771
PRSS3
protease, serine, 3
chr12_+_6554032 6.062 NM_001242
CD27
CD27 molecule
chr12_-_42877785 5.987 NM_001144882
NM_001144883
PRICKLE1

prickle homolog 1 (Drosophila)

chr16_-_67260900 5.816 NM_001004055
LRRC29
leucine rich repeat containing 29
chr5_+_140261792 5.783 NM_018904
NM_031865
PCDHA13

protocadherin alpha 13

chrX_-_106959597 5.755 NM_001015881
TSC22D3
TSC22 domain family, member 3
chr10_+_95753684 5.746 NM_016341
PLCE1
phospholipase C, epsilon 1
chr5_+_71502700 5.744 MAP1B
microtubule-associated protein 1B
chrX_-_48931645 5.719 NM_007213
PRAF2
PRA1 domain family, member 2
chr9_-_86571533 5.711 C9orf64
chromosome 9 open reading frame 64
chr3_-_158450205 5.671 RARRES1
retinoic acid receptor responder (tazarotene induced) 1
chr1_-_24513737 5.561 NM_170743
NM_173064
NM_173065
IL28RA


interleukin 28 receptor, alpha (interferon, lambda receptor)


chr5_-_121814781 5.545


chr6_-_111136616 5.528 CDK19
cyclin-dependent kinase 19
chr5_-_111092918 5.503 NM_004772
C5orf13
chromosome 5 open reading frame 13
chr2_-_175499275 5.502 NM_003387
WIPF1
WAS/WASL interacting protein family, member 1
chr20_+_58251715 5.440 NM_001199506
PHACTR3
phosphatase and actin regulator 3
chr9_-_86571631 5.438 C9orf64
chromosome 9 open reading frame 64
chr10_+_74870209 5.429 NM_015901
NUDT13
nudix (nucleoside diphosphate linked moiety X)-type motif 13
chr4_+_41258895 5.417 NM_004181
UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr19_+_36980524 5.395 LOC728752
uncharacterized LOC728752
chr4_-_110723127 5.382 CFI
complement factor I
chr19_+_49977465 5.291 NM_001204502
NM_001459
FLT3LG

fms-related tyrosine kinase 3 ligand

chrX_-_106960028 5.287 TSC22D3
TSC22 domain family, member 3
chr21_-_43816123 5.278 NM_024022
NM_032405
TMPRSS3

transmembrane protease, serine 3

chr1_-_205391180 5.252 NM_001001552
NM_001199050
NM_001199051
NM_001199052
LEMD1



LEM domain containing 1



chr19_+_44556163 5.226 NM_013361
ZNF223
zinc finger protein 223
chr6_-_111136407 5.205 NM_015076
CDK19
cyclin-dependent kinase 19
chr5_-_137514299 5.159 NM_001164326
NM_006696
NM_139199
BRD8


bromodomain containing 8


chr9_-_86571652 5.158 NM_032307
C9orf64
chromosome 9 open reading frame 64
chr5_+_81601165 5.149 NM_001017971
ATP6AP1L
ATPase, H+ transporting, lysosomal accessory protein 1-like
chr5_+_42549657 5.108 NM_001242404
GHR
growth hormone receptor
chr5_-_121414011 5.100 NM_002317
LOX
lysyl oxidase
chr6_+_31913852 5.068 CFB
complement factor B
chr2_-_216300444 5.047 FN1
fibronectin 1
chr3_+_38035614 5.037 VILL
villin-like
chr17_-_42466840 4.983 NM_000419
ITGA2B
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
chr4_-_186732047 4.936 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr14_+_75745480 4.928 NM_005252
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr5_-_121413906 4.919 LOX
lysyl oxidase
chr1_+_212788359 4.891 NM_001206486
ATF3
activating transcription factor 3
chr6_+_31913920 4.802 CFB
complement factor B
chr5_+_178450775 4.739 NM_001136116
ZNF879
zinc finger protein 879
chr6_+_46097818 4.727 ENPP4
ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
chr2_+_31456879 4.705 NM_014600
EHD3
EH-domain containing 3
chr19_-_37341168 4.669 NM_001242801
ZNF790
zinc finger protein 790
chr6_+_31913708 4.651 NM_001710
CFB
complement factor B
chr4_-_186733372 4.650 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr5_-_121413967 4.638 LOX
lysyl oxidase
chrX_-_64196268 4.596 NM_001178033
NM_018684
ZC4H2

zinc finger, C4H2 domain containing

chrX_-_154563735 4.580 NM_001289
CLIC2
chloride intracellular channel 2
chr12_+_7167979 4.501 NM_001734
NM_201442
C1S

complement component 1, s subcomponent

chr12_-_42877743 4.465 PRICKLE1
prickle homolog 1 (Drosophila)
chr1_+_160370363 4.459 NM_020335
VANGL2
vang-like 2 (van gogh, Drosophila)
chr12_-_57146081 4.411 NM_000946
PRIM1
primase, DNA, polypeptide 1 (49kDa)
chr3_-_64211111 4.408 NM_198859
PRICKLE2
prickle homolog 2 (Drosophila)
chr19_+_37341259 4.397 NM_003419
ZNF345
zinc finger protein 345
chr12_-_56727720 4.391 NM_001166279
NM_014871
PAN2

PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)

chr1_-_51787881 4.265 NM_001080494
TTC39A
tetratricopeptide repeat domain 39A
chr1_-_115632047 4.236 NM_005725
TSPAN2
tetraspanin 2
chr1_-_144994908 4.229 PDE4DIP
phosphodiesterase 4D interacting protein
chr1_+_158901336 4.222 NM_152501
NM_198928
NM_198929
NM_198930
PYHIN1



pyrin and HIN domain family, member 1



chr5_+_140501399 4.176 PCDHB4
protocadherin beta 4
chr5_+_140501579 4.154 NM_018938
PCDHB4
protocadherin beta 4
chr5_-_111093251 4.152 NM_001142479
NM_001142480
NM_001142478
C5orf13


chromosome 5 open reading frame 13


chr9_+_126773851 4.149 NM_004789
LHX2
LIM homeobox 2
chr19_+_40502942 4.123 NM_178544
ZNF546
zinc finger protein 546
chr19_-_41934634 4.111 NM_198540
B3GNT8
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8
chr6_-_36355342 4.075 NM_001207038
NM_001207035
NM_001207036
NM_001207037
NM_001207039
NM_001207040
NM_001207041
NM_016135
ETV7







ets variant 7







chr13_-_43566301 4.064 NM_001002264
NM_033255
EPSTI1

epithelial stromal interaction 1 (breast)

chr6_+_31913763 4.037 CFB
complement factor B
chr3_+_38035077 4.024 NM_015873
VILL
villin-like
chr5_+_145316120 4.021 NM_152550
SH3RF2
SH3 domain containing ring finger 2
chr17_+_40440481 4.015 STAT5A
signal transducer and activator of transcription 5A
chr4_-_77819001 3.987 NM_001029870
ANKRD56
ankyrin repeat domain 56
chrX_-_84634664 3.965 POF1B
premature ovarian failure, 1B
chr2_-_175547471 3.956 NM_001077269
WIPF1
WAS/WASL interacting protein family, member 1
chr3_-_158450230 3.955 RARRES1
retinoic acid receptor responder (tazarotene induced) 1
chr1_-_183274008 3.913 NM_170706
NMNAT2
nicotinamide nucleotide adenylyltransferase 2
chr19_-_36980336 3.907 NM_032838
NM_001145343
NM_001145344
NM_001145345
ZNF566



zinc finger protein 566



chr17_+_57915192 3.888


chr17_-_33700619 3.878 NM_001104587
NM_001104588
NM_001104589
NM_001104590
NM_152270
SLFN11




schlafen family member 11




chr12_+_53443834 3.877 NM_170754
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr1_+_205538164 3.876 MFSD4
major facilitator superfamily domain containing 4
chr15_+_50474357 3.787 NM_001159629
NM_003645
SLC27A2

solute carrier family 27 (fatty acid transporter), member 2

chrX_-_84634742 3.758 NM_024921
POF1B
premature ovarian failure, 1B
chr19_+_41281281 3.752 NM_006533
MIA
melanoma inhibitory activity
chr2_+_201450730 3.702 NM_001159
AOX1
aldehyde oxidase 1
chr16_+_55512801 3.695 NM_004530
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr3_-_158450271 3.692 NM_002888
NM_206963
RARRES1

retinoic acid receptor responder (tazarotene induced) 1

chr19_+_49977817 3.691 NM_001204503
FLT3LG
fms-related tyrosine kinase 3 ligand
chrX_-_106362018 3.615 RBM41
RNA binding motif protein 41
chrX_-_106362050 3.610 NM_001171080
NM_018301
RBM41

RNA binding motif protein 41

chr9_-_130689697 3.566 NM_173492
PIP5KL1
phosphatidylinositol-4-phosphate 5-kinase-like 1
chr7_+_74508346 3.556 NM_001003795
GTF2IRD2B
GTF2IRD2
GTF2I repeat domain containing 2B
GTF2I repeat domain containing 2
chrX_-_64139016 3.540 ZC4H2
zinc finger, C4H2 domain containing
chr8_-_143859638 3.540 NM_023946
NM_177457
LYNX1

Ly6/neurotoxin 1

chr17_+_40834571 3.533 NM_003632
CNTNAP1
contactin associated protein 1
chr2_+_201450579 3.515 AOX1
aldehyde oxidase 1
chr11_-_85437457 3.500 NM_206927
NM_206928
SYTL2

synaptotagmin-like 2

chr6_+_32821924 3.494 NM_002800
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)
chr6_+_31895401 3.490 C2
complement component 2
chr19_-_51504799 3.478 NM_007196
NM_144505
NM_144506
NM_144507
KLK8



kallikrein-related peptidase 8



chr15_+_84322809 3.470 NM_207517
ADAMTSL3
ADAMTS-like 3
chr5_+_137514416 3.454 NM_005733
KIF20A
kinesin family member 20A
chr1_+_159796506 3.441 SLAMF8
SLAM family member 8
chr16_+_30996462 3.441 NM_001142777
NM_001142778
NM_025193
HSD3B7


hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7


chr6_-_56716412 3.432 DST
dystonin
chr5_+_137514753 3.422 KIF20A
kinesin family member 20A
chr1_+_43291230 3.401 NM_018538
ERMAP
erythroblast membrane-associated protein (Scianna blood group)
chr19_+_45417576 3.395 APOC1
apolipoprotein C-I
chr1_+_153940345 3.377 NM_130898
CREB3L4
cAMP responsive element binding protein 3-like 4
chr2_-_160654668 3.370 CD302
CD302 molecule
chr7_+_150549577 3.350 ABP1
amiloride binding protein 1 (amine oxidase (copper-containing))
chr5_-_111312522 3.336 NM_001142474
NM_001142475
C5orf13

chromosome 5 open reading frame 13

chr6_+_138188352 3.323 NM_006290
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr12_+_21679190 3.321 NM_030572
C12orf39
chromosome 12 open reading frame 39
chr12_-_15091441 3.316 NM_152321
ERP27
endoplasmic reticulum protein 27
chr6_-_111136330 3.301 CDK19
cyclin-dependent kinase 19
chr11_+_65271145 3.295


chr4_-_185395616 3.269 NM_002199
IRF2
interferon regulatory factor 2
chrX_+_106045880 3.251 NM_017752
NM_198881
TBC1D8B

TBC1 domain family, member 8B (with GRAM domain)

chr2_+_71693817 3.251 NM_001130455
NM_001130982
NM_001130983
NM_001130984
NM_001130985
NM_001130986
NM_001130987
DYSF






dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)






chr1_-_144994943 3.248 NM_001002812
NM_014644
NM_001002810
NM_001198834
NM_001195261
PDE4DIP




phosphodiesterase 4D interacting protein




chr6_-_28304151 3.239 NM_001243241
NM_001243242
NM_001243244
NM_030899
ZNF323



zinc finger protein 323



chr4_+_187070326 3.238 NM_001006655
FAM149A
family with sequence similarity 149, member A
chr14_-_54423448 3.204 NM_001202
NM_130850
BMP4

bone morphogenetic protein 4

chr1_-_116383323 3.201 NM_001111061
NHLH2
nescient helix loop helix 2
chr15_-_55652777 3.199 CCPG1
cell cycle progression 1
chr12_+_116971196 3.188 LINC00173
long intergenic non-protein coding RNA 173
chr3_-_123603144 3.172 NM_053025
NM_053026
NM_053027
NM_053028
MYLK



myosin light chain kinase



chr1_-_182360400 3.172 NM_001033056
GLUL
glutamate-ammonia ligase
chr5_+_140306301 3.166 NM_018898
NM_031882
PCDHAC1

protocadherin alpha subfamily C, 1

chrX_-_38079980 3.156 NM_001170750
NM_001170751
NM_001170752
NM_006307
SRPX



sushi-repeat containing protein, X-linked



chr11_-_82996898 3.125 CCDC90B
coiled-coil domain containing 90B
chr12_-_7261788 3.114 NM_016546
C1RL
complement component 1, r subcomponent-like
chr15_+_71184781 3.086 NM_001199017
NM_017691
NM_001199018
LRRC49


leucine rich repeat containing 49


chr17_+_1648262 3.084 SERPINF2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr4_+_86396251 3.070 NM_001025616
ARHGAP24
Rho GTPase activating protein 24
chr1_+_209859524 3.056 NM_001206741
NM_181755
HSD11B1

hydroxysteroid (11-beta) dehydrogenase 1

chr2_-_145275086 3.030 ZEB2
zinc finger E-box binding homeobox 2
chr14_+_32798478 3.017 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
8.74 3.69e-03 GO:0006958 complement activation, classical pathway
7.25 4.62e-03 GO:0006956 complement activation
2.67 6.07e-03 GO:0045087 innate immune response
6.16 6.35e-03 GO:0016064 immunoglobulin mediated immune response
6.05 7.53e-03 GO:0019724 B cell mediated immunity
5.40 8.04e-03 GO:0002449 lymphocyte mediated immunity
7.74 9.91e-03 GO:0002455 humoral immune response mediated by circulating immunoglobulin
5.03 1.61e-02 GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
5.55 1.67e-02 GO:0072376 protein activation cascade
4.90 2.10e-02 GO:0002250 adaptive immune response
1.97 2.77e-02 GO:0006952 defense response
1.21 3.42e-02 GO:0065007 biological regulation
1.53 4.96e-02 GO:0006355 regulation of transcription, DNA-dependent

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
2.32 4.40e-06 GO:0005615 extracellular space
2.06 2.04e-05 GO:0044421 extracellular region part
1.62 4.93e-04 GO:0005576 extracellular region

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
3.53 7.80e-03 GO:0004252 serine-type endopeptidase activity
2.00 1.76e-02 GO:0005509 calcium ion binding
2.39 1.89e-02 GO:0004175 endopeptidase activity
2.07 2.82e-02 GO:0070011 peptidase activity, acting on L-amino acid peptides
1.32 3.30e-02 GO:0043169 cation binding
1.32 3.72e-02 GO:0043167 ion binding
3.04 4.31e-02 GO:0008236 serine-type peptidase activity
1.32 4.33e-02 GO:0046872 metal ion binding