Motif ID: SRF.p3

Z-value: 2.762


Transcription factors associated with SRF.p3:

Gene SymbolEntrez IDGene Name
SRF 6722 serum response factor (c-fos serum response element-binding transcription factor)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SRFhg19_v1_chr6_+_43139201_431393860.846.2e-21Click!


Activity profile for motif SRF.p3.

activity profile for motif SRF.p3


Sorted Z-values histogram for motif SRF.p3

Sorted Z-values for motif SRF.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of SRF.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_137801166 90.359 EGR1
early growth response 1
chr5_+_137801178 78.340 NM_001964
EGR1
early growth response 1
chr10_-_64576123 61.515 NM_000399
NM_001136177
NM_001136179
EGR2


early growth response 2


chr10_-_64576074 59.835 EGR2
early growth response 2
chr12_+_52445185 48.827 NM_002135
NM_173157
NR4A1

nuclear receptor subfamily 4, group A, member 1

chr10_+_112257624 40.661 NM_004419
DUSP5
dual specificity phosphatase 5
chr2_-_73520448 37.210 NM_001965
EGR4
early growth response 4
chr2_-_96811138 32.459 NM_004418
DUSP2
dual specificity phosphatase 2
chr8_-_22550708 31.839 NM_004430
EGR3
early growth response 3
chr2_-_96810775 30.251 DUSP2
dual specificity phosphatase 2
chr11_-_65667858 30.036 FOSL1
FOS-like antigen 1
chr11_-_65667860 26.023 NM_005438
FOSL1
FOS-like antigen 1
chr11_-_65667809 25.479 FOSL1
FOS-like antigen 1
chr19_+_45971249 20.205 NM_001114171
NM_006732
FOSB

FBJ murine osteosarcoma viral oncogene homolog B

chr3_-_99594915 17.486 NM_014890
FILIP1L
filamin A interacting protein 1-like
chr6_+_126240369 13.667 NM_001199622
NCOA7
nuclear receptor coactivator 7
chr1_-_89530890 12.552 NM_002053
GBP1
guanylate binding protein 1, interferon-inducible
chr6_+_43138919 12.440 NM_003131
SRF
serum response factor (c-fos serum response element-binding transcription factor)
chr11_+_117070039 11.653 NM_001001522
NM_003186
TAGLN

transgelin

chr6_-_29644930 11.240 NM_001109809
ZFP57
zinc finger protein 57 homolog (mouse)
chr17_+_57915192 11.027


chr6_+_151561094 10.846 NM_005100
AKAP12
A kinase (PRKA) anchor protein 12
chr12_+_75874512 10.441 NM_006851
GLIPR1
GLI pathogenesis-related 1
chr6_+_43139190 9.137 SRF
serum response factor (c-fos serum response element-binding transcription factor)
chr2_-_106015423 9.000 NM_001039492
NM_001450
NM_201555
FHL2


four and a half LIM domains 2


chr2_-_161056762 8.918 ITGB6
integrin, beta 6
chr6_+_43139201 8.309 SRF
serum response factor (c-fos serum response element-binding transcription factor)
chr20_+_35169876 8.015 NM_006097
NM_181526
MYL9

myosin, light chain 9, regulatory

chr20_+_35169897 7.664 MYL9
myosin, light chain 9, regulatory
chr2_+_74120132 7.591 ACTG2
actin, gamma 2, smooth muscle, enteric
chr1_+_181057835 7.577 IER5
immediate early response 5
chr7_-_44180911 6.841 NM_021223
MYL7
myosin, light chain 7, regulatory
chr19_+_54372659 6.320 NM_001020821
NM_001020818
MYADM

myeloid-associated differentiation marker

chr22_+_31480981 6.291 NM_001207018
SMTN
smoothelin
chr6_+_151561508 6.099 AKAP12
A kinase (PRKA) anchor protein 12
chr19_+_16178170 5.798 NM_001145160
TPM4
tropomyosin 4
chr12_-_50616425 5.682 NM_001113547
LIMA1
LIM domain and actin binding 1
chr6_-_159466019 5.450 NM_054114
NM_138810
NM_152133
TAGAP


T-cell activation RhoGTPase activating protein


chr2_-_161056573 5.350 NM_000888
ITGB6
integrin, beta 6
chr14_-_53417808 5.256 NM_001134999
NM_001135000
NM_006832
FERMT2


fermitin family member 2


chr7_+_143078358 5.082 NM_001010972
NM_003461
ZYX

zyxin

chr1_-_11907741 5.037 NM_006172
NPPA
natriuretic peptide A
chr10_-_29923841 5.026


chr1_-_153433104 5.012 NM_002963
S100A7
S100 calcium binding protein A7
chr14_+_75745480 4.990 NM_005252
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr3_-_151987332 4.971 LOC401093
uncharacterized LOC401093
chr7_+_143078399 4.773 ZYX
zyxin
chr17_+_3379295 4.551 NM_000049
ASPA
aspartoacylase
chr1_-_150552077 4.482 MCL1
myeloid cell leukemia sequence 1 (BCL2-related)
chr1_+_113263188 4.475 NM_001004440
NM_182759
FAM19A3

family with sequence similarity 19 (chemokine (C-C motif)-like), member A3

chr19_+_1026608 4.423 CNN2
calponin 2
chr2_-_151344145 4.371 NM_005168
RND3
Rho family GTPase 3
chr17_-_39203423 4.360 NM_001123387
KRTAP2-1
keratin associated protein 2-1
chr19_+_1026624 4.212 CNN2
calponin 2
chr10_+_6186903 4.203 PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr10_+_6186758 4.191 NM_001145443
PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr7_+_143078395 4.139 ZYX
zyxin
chr7_+_143078447 4.115 ZYX
zyxin
chr7_+_143078444 4.105 ZYX
zyxin
chr19_+_1026582 4.069 CNN2
calponin 2
chr5_-_142000899 4.054 NM_001144892
FGF1
fibroblast growth factor 1 (acidic)
chr19_+_48958765 3.973 NM_013348
KCNJ14
potassium inwardly-rectifying channel, subfamily J, member 14
chr3_-_123339178 3.934 MYLK
myosin light chain kinase
chr1_+_16085245 3.915 NM_017556
FBLIM1
filamin binding LIM protein 1
chr1_-_91487769 3.813 NM_032186
NM_201269
ZNF644

zinc finger protein 644

chr2_+_74120092 3.802 NM_001199893
NM_001615
ACTG2

actin, gamma 2, smooth muscle, enteric

chr19_-_46220589 3.606


chr19_+_45417576 3.584 APOC1
apolipoprotein C-I
chr12_+_6881669 3.472 NM_002286
LAG3
lymphocyte-activation gene 3
chr7_+_143078457 3.448 ZYX
zyxin
chr19_+_49376488 3.257 PPP1R15A
protein phosphatase 1, regulatory subunit 15A
chr1_+_151512760 3.182 NM_001126337
NM_020127
TUFT1

tuftelin 1

chr1_-_91487593 3.180 ZNF644
zinc finger protein 644
chr10_-_82049178 3.131 NM_000429
MAT1A
methionine adenosyltransferase I, alpha
chr19_+_1026627 3.089 CNN2
calponin 2
chr1_-_68915631 3.044 NM_000329
RPE65
retinal pigment epithelium-specific protein 65kDa
chr1_+_153388999 3.044 NM_176823
S100A7A
S100 calcium binding protein A7A
chr4_+_155665150 2.977 NM_004744
LRAT
lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
chr1_-_229569839 2.964 NM_001100
ACTA1
actin, alpha 1, skeletal muscle
chr19_+_2476122 2.933 NM_015675
GADD45B
growth arrest and DNA-damage-inducible, beta
chr19_-_36247917 2.833 NM_144617
HSPB6
heat shock protein, alpha-crystallin-related, B6
chr5_-_58295758 2.797 NM_001197223
PDE4D
phosphodiesterase 4D, cAMP-specific
chr2_-_208031570 2.792 KLF7
Kruppel-like factor 7 (ubiquitous)
chr17_-_79479831 2.791 NM_001199954
NM_001614
ACTG1

actin, gamma 1

chr17_-_78450247 2.654 NM_002522
NPTX1
neuronal pentraxin I
chr3_-_123339423 2.633 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr7_+_143078608 2.620 ZYX
zyxin
chr16_-_69385656 2.591 NM_144676
TMED6
transmembrane emp24 protein transport domain containing 6
chr11_+_66314373 2.566 NM_001104
ACTN3
actinin, alpha 3
chr10_+_6186878 2.536 PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr6_-_16761600 2.505 NM_000332
NM_001128164
ATXN1

ataxin 1

chr4_+_108814419 2.465 NM_001136257
NM_152621
SGMS2

sphingomyelin synthase 2

chr3_-_156878481 2.422 NM_020307
CCNL1
cyclin L1
chr10_+_81107219 2.412 NM_005729
PPIF
peptidylprolyl isomerase F
chr5_-_53606303 2.376 ARL15
ADP-ribosylation factor-like 15
chr20_-_34243118 2.358 RBM12
RNA binding motif protein 12
chr19_+_57901330 2.319 ZNF548
ZNF17
zinc finger protein 548
zinc finger protein 17
chr19_+_57901188 2.261 NM_001172773
NM_152909
ZNF548

zinc finger protein 548

chr19_-_12146503 2.255 NM_001080411
ZNF433
zinc finger protein 433
chr17_-_79479780 2.217 ACTG1
actin, gamma 1
chr1_-_150552005 2.209 MCL1
myeloid cell leukemia sequence 1 (BCL2-related)
chr10_+_75757847 2.203 NM_003373
NM_014000
VCL

vinculin

chr1_+_28099682 2.118 NM_177424
STX12
syntaxin 12
chr5_-_33891967 2.035 NM_030955
ADAMTS12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr12_-_48119224 2.021 NM_001172439
NM_001172440
NM_006025
ENDOU


endonuclease, polyU-specific


chr3_+_143690639 1.977 NM_173552
C3orf58
chromosome 3 open reading frame 58
chr10_+_81107259 1.967 PPIF
peptidylprolyl isomerase F
chr2_+_26915390 1.842 NM_002246
KCNK3
potassium channel, subfamily K, member 3
chr10_+_81107228 1.819 PPIF
peptidylprolyl isomerase F
chr9_+_36136710 1.810 NM_022343
GLIPR2
GLI pathogenesis-related 2
chr14_-_94443065 1.785 NM_001202429
ASB2
ankyrin repeat and SOCS box containing 2
chr17_-_3867585 1.726 NM_005173
NM_174953
NM_174954
NM_174955
NM_174956
NM_174957
NM_174958
ATP2A3






ATPase, Ca++ transporting, ubiquitous






chr12_+_26348488 1.686 NM_005086
SSPN
sarcospan (Kras oncogene-associated gene)
chr20_-_21494663 1.580 NM_002509
NKX2-2
NK2 homeobox 2
chr5_-_53606387 1.525 NM_019087
ARL15
ADP-ribosylation factor-like 15
chr19_+_16187306 1.497 TPM4
tropomyosin 4
chr2_-_231989755 1.495 NM_000867
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B
chr4_-_10118460 1.493 WDR1
WD repeat domain 1
chr5_+_140254930 1.449 NM_018903
NM_031864
PCDHA12

protocadherin alpha 12

chr5_-_33892292 1.425 ADAMTS12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr2_+_101179395 1.412 NM_024065
PDCL3
phosducin-like 3
chr4_-_10118444 1.404 WDR1
WD repeat domain 1
chr20_-_62258330 1.400 NM_012384
GMEB2
glucocorticoid modulatory element binding protein 2
chr12_+_27933162 1.367 NM_020782
KLHDC5
kelch domain containing 5
chr19_+_45417920 1.353 NM_001645
APOC1
apolipoprotein C-I
chr17_-_79792867 1.331 PPP1R27
protein phosphatase 1, regulatory subunit 27
chr11_-_16430425 1.294 NM_001145811
SOX6
SRY (sex determining region Y)-box 6
chr22_-_36784055 1.293 NM_002473
MYH9
myosin, heavy chain 9, non-muscle
chr10_+_81107242 1.283 PPIF
peptidylprolyl isomerase F
chr6_-_117150197 1.211 NM_148963
GPRC6A
G protein-coupled receptor, family C, group 6, member A
chr17_-_39684585 1.186 NM_002276
KRT19
keratin 19
chr7_-_5570188 1.182 NM_001101
ACTB
actin, beta
chr13_-_99959649 1.160 NM_004951
GPR183
G protein-coupled receptor 183
chr17_+_41132581 1.115 NM_173079
RUNDC1
RUN domain containing 1
chr15_-_70390226 1.099 TLE3
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
chr21_-_28217272 1.058 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr4_-_10118500 1.041 NM_005112
NM_017491
WDR1

WD repeat domain 1

chr9_+_140772228 1.037 NM_000718
NM_001243812
CACNA1B

calcium channel, voltage-dependent, N type, alpha 1B subunit

chr17_+_41132587 1.014 RUNDC1
RUN domain containing 1
chr13_-_46742678 1.013 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr19_+_16187047 1.011 NM_003290
TPM4
tropomyosin 4
chr11_-_119294242 1.003 NM_006288
THY1
Thy-1 cell surface antigen
chr15_-_45670624 0.965 GATM
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr7_-_5569200 0.962 ACTB
actin, beta
chr4_+_24797084 0.960 NM_003102
SOD3
superoxide dismutase 3, extracellular
chr1_-_89488412 0.923 NM_018284
GBP3
guanylate binding protein 3
chr19_-_15343767 0.916 NM_001142886
EPHX3
epoxide hydrolase 3
chr3_-_9834357 0.903 NM_006354
NM_133480
TADA3

transcriptional adaptor 3

chr1_-_208084379 0.890 CD34
CD34 molecule
chr20_-_62258422 0.881 GMEB2
glucocorticoid modulatory element binding protein 2
chr1_-_147245483 0.880 NM_005266
GJA5
gap junction protein, alpha 5, 40kDa
chr1_-_208084432 0.869 NM_001025109
NM_001773
CD34

CD34 molecule

chr5_-_111093251 0.863 NM_001142479
NM_001142480
NM_001142478
C5orf13


chromosome 5 open reading frame 13


chr21_-_35987144 0.845 NM_004414
RCAN1
regulator of calcineurin 1
chr3_+_67048726 0.844 NM_032505
KBTBD8
kelch repeat and BTB (POZ) domain containing 8
chr6_-_39693110 0.838 NM_145027
KIF6
kinesin family member 6
chr15_+_33603162 0.819 NM_001036
NM_001243996
RYR3

ryanodine receptor 3

chr9_+_130911731 0.810 NM_005564
LCN2
lipocalin 2
chr15_-_59665065 0.809 MYO1E
myosin IE
chr3_+_9834778 0.809 NM_001198780
ARPC4
actin related protein 2/3 complex, subunit 4, 20kDa
chr1_-_152196668 0.789 NM_001009931
HRNR
hornerin
chr1_-_91487586 0.769 ZNF644
zinc finger protein 644
chr14_+_74706174 0.759 NM_182894
VSX2
visual system homeobox 2
chr7_+_20686965 0.752 NM_001163942
NM_001163993
NM_178559
ABCB5


ATP-binding cassette, sub-family B (MDR/TAP), member 5


chr5_-_179050675 0.740 NM_005520
HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr11_+_66188474 0.737 NM_178864
NPAS4
neuronal PAS domain protein 4
chr19_+_1026271 0.736 NM_004368
NM_201277
CNN2

calponin 2

chr2_+_131513007 0.726 NM_152698
NM_001105193
FAM123C

family with sequence similarity 123C

chr2_-_135476541 0.696 NM_030923
TMEM163
transmembrane protein 163
chr14_-_55369163 0.684 NM_000161
NM_001024024
NM_001024070
NM_001024071
GCH1



GTP cyclohydrolase 1



chr4_-_88450243 0.678 SPARCL1
SPARC-like 1 (hevin)
chr4_-_88450601 0.674 NM_001128310
NM_004684
SPARCL1

SPARC-like 1 (hevin)

chr7_+_115863004 0.658 NM_152829
TES
testis derived transcript (3 LIM domains)
chr15_-_59665069 0.650 NM_004998
MYO1E
myosin IE
chr10_+_64280206 0.646 NM_199452
ZNF365
zinc finger protein 365
chr6_-_88411872 0.626 AKIRIN2
akirin 2
chr14_-_94442894 0.610 ASB2
ankyrin repeat and SOCS box containing 2
chr6_-_88411649 0.609 AKIRIN2
akirin 2
chr6_-_88411948 0.608 AKIRIN2
akirin 2
chr19_-_47975244 0.585 NM_015063
SLC8A2
solute carrier family 8 (sodium/calcium exchanger), member 2
chr3_+_63953419 0.585 NM_001128149
ATXN7
ataxin 7
chr18_+_61144143 0.583 NM_002639
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr1_-_201346783 0.568 TNNT2
troponin T type 2 (cardiac)
chr6_+_158402916 0.565 SYNJ2
synaptojanin 2
chrX_-_11284094 0.564 NM_013423
ARHGAP6
Rho GTPase activating protein 6
chr11_-_57282315 0.559 NM_001198810
SLC43A1
solute carrier family 43, member 1
chr17_-_46671322 0.546 HOXB5
homeobox B5
chr2_-_216248184 0.530 FN1
fibronectin 1
chr11_-_2162167 0.527 IGF2
insulin-like growth factor 2 (somatomedin A)
chr16_-_67977956 0.526 NM_000229
LCAT
lecithin-cholesterol acyltransferase
chr15_-_65360297 0.520 NM_016563
RASL12
RAS-like, family 12
chr17_-_79792923 0.518 NM_001007533
PPP1R27
protein phosphatase 1, regulatory subunit 27
chr17_+_33474835 0.512 NM_001033576
NM_173167
UNC45B

unc-45 homolog B (C. elegans)

chr17_+_41003184 0.491 NM_003734
AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr11_-_119293848 0.486 THY1
Thy-1 cell surface antigen
chr20_+_4702499 0.479 NM_012409
PRND
prion protein 2 (dublet)
chr15_+_74218962 0.469 LOXL1
lysyl oxidase-like 1
chr1_+_76540374 0.466 NM_001160011
NM_152996
ST6GALNAC3

ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3

chr10_-_85931723 0.466 LOC642934
uncharacterized LOC642934
chr1_-_35324645 0.465 NM_001164824
C1orf212
chromosome 1 open reading frame 212

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
12.39 7.54e-07 GO:0006936 muscle contraction
11.38 1.85e-06 GO:0003012 muscle system process
7.91 2.06e-05 GO:0030029 actin filament-based process
1.92 5.82e-05 GO:0032501 multicellular organismal process
2.13 1.01e-03 GO:0007275 multicellular organismal development
2.00 3.60e-03 GO:0032502 developmental process
6.88 3.69e-03 GO:0030036 actin cytoskeleton organization
17.44 5.57e-03 GO:0030048 actin filament-based movement
2.53 8.44e-03 GO:0048513 organ development
2.08 8.70e-03 GO:0048856 anatomical structure development
1.63 1.37e-02 GO:0050896 response to stimulus
1.50 1.55e-02 GO:0065007 biological regulation
2.54 2.03e-02 GO:0003008 system process
2.11 2.04e-02 GO:0048731 system development
2.67 2.46e-02 GO:0009653 anatomical structure morphogenesis
8.41 4.63e-02 GO:0034329 cell junction assembly

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
50.80 2.22e-10 GO:0001725 stress fiber
47.41 4.15e-10 GO:0032432 actin filament bundle
43.10 9.70e-10 GO:0042641 actomyosin
9.33 6.30e-09 GO:0015629 actin cytoskeleton
14.37 8.85e-06 GO:0005925 focal adhesion
13.68 1.30e-05 GO:0005924 cell-substrate adherens junction
10.75 1.65e-05 GO:0005912 adherens junction
13.18 1.75e-05 GO:0030055 cell-substrate junction
9.71 3.94e-05 GO:0070161 anchoring junction
2.85 3.42e-04 GO:0005856 cytoskeleton
11.02 3.60e-04 GO:0044449 contractile fiber part
10.13 6.33e-04 GO:0043292 contractile fiber
1.30 2.75e-03 GO:0044424 intracellular part
20.92 4.11e-03 GO:0005884 actin filament
6.22 4.73e-03 GO:0016323 basolateral plasma membrane
9.20 5.20e-03 GO:0030016 myofibril
3.77 8.26e-03 GO:0030054 cell junction
1.27 1.02e-02 GO:0005622 intracellular
2.86 1.36e-02 GO:0044430 cytoskeletal part
9.08 2.44e-02 GO:0030017 sarcomere
1.32 4.25e-02 GO:0043229 intracellular organelle
1.32 4.54e-02 GO:0043226 organelle
11.12 4.96e-02 GO:0016459 myosin complex

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
20.68 5.17e-04 GO:0008307 structural constituent of muscle
5.67 1.32e-03 GO:0003779 actin binding
3.81 1.82e-02 GO:0008092 cytoskeletal protein binding