Motif ID: SREBF1,2.p2

Z-value: 1.376


Transcription factors associated with SREBF1,2.p2:

Gene SymbolEntrez IDGene Name
SREBF1 6720 sterol regulatory element binding transcription factor 1
SREBF2 6721 sterol regulatory element binding transcription factor 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SREBF2hg19_v1_chr22_+_42229137_422292660.743.6e-14Click!
SREBF1hg19_v1_chr17_-_17740309_17740339-0.521.9e-06Click!


Activity profile for motif SREBF1,2.p2.

activity profile for motif SREBF1,2.p2


Sorted Z-values histogram for motif SREBF1,2.p2

Sorted Z-values for motif SREBF1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SREBF1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_-_44519629 20.539 NM_080749
NEURL2
neuralized homolog 2 (Drosophila)
chr1_-_11866079 15.000 NM_005957
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr12_+_57998600 14.255 NM_178502
DTX3
deltex homolog 3 (Drosophila)
chr22_-_38577692 12.458 NM_001004426
NM_003560
NM_001199562
PLA2G6


phospholipase A2, group VI (cytosolic, calcium-independent)


chr1_-_11865963 12.409 MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr13_-_33002218 12.264 NM_001079691
NM_052818
N4BP2L1

NEDD4 binding protein 2-like 1

chr17_-_7137580 11.640 DVL2
dishevelled, dsh homolog 2 (Drosophila)
chr20_-_39317875 11.364 NM_005461
MAFB
v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)
chr1_-_156265395 11.162 NM_144580
C1orf85
chromosome 1 open reading frame 85
chr5_+_172483285 11.118 NM_001168393
NM_001168394
NM_153607
C5orf41


chromosome 5 open reading frame 41


chr17_-_7137722 11.069 NM_004422
DVL2
dishevelled, dsh homolog 2 (Drosophila)
chr17_-_42200957 10.905 HDAC5
histone deacetylase 5
chr17_-_42201009 10.734 NM_001015053
NM_005474
HDAC5

histone deacetylase 5

chr6_-_33714681 10.686 NM_001142883
NM_054111
IP6K3

inositol hexakisphosphate kinase 3

chr15_-_72668301 10.338 NM_000520
HEXA
hexosaminidase A (alpha polypeptide)
chrX_-_114797017 10.255


chr16_+_2570322 10.087 NM_001145815
NM_015944
AMDHD2

amidohydrolase domain containing 2

chr19_-_41256371 9.974 C19orf54
chromosome 19 open reading frame 54
chr3_-_187463227 9.741 BCL6
B-cell CLL/lymphoma 6
chr19_-_41256349 9.713 C19orf54
chromosome 19 open reading frame 54
chr11_-_18343670 9.651 NM_007216
NM_181507
NM_181508
HPS5


Hermansky-Pudlak syndrome 5


chrX_+_102631408 9.485 NGFRAP1
nerve growth factor receptor (TNFRSF16) associated protein 1
chr22_+_42394728 9.437 NM_152613
WBP2NL
WBP2 N-terminal like
chr1_-_154928564 9.365 NM_020524
PBXIP1
pre-B-cell leukemia homeobox interacting protein 1
chr17_-_7137675 9.260 DVL2
dishevelled, dsh homolog 2 (Drosophila)
chr19_-_10764449 9.193 LOC147727
uncharacterized LOC147727
chr1_-_156265457 9.172 C1orf85
chromosome 1 open reading frame 85
chr3_-_187463474 9.113 NM_001706
BCL6
B-cell CLL/lymphoma 6
chr12_-_49318663 9.075 NM_001143781
FKBP11
FK506 binding protein 11, 19 kDa
chr19_-_36545119 8.869 THAP8
THAP domain containing 8
chr5_-_154230212 8.721 NM_032385
C5orf4
chromosome 5 open reading frame 4
chr5_-_154230157 8.548 C5orf4
chromosome 5 open reading frame 4
chrX_-_106960268 8.389 NM_004089
TSC22D3
TSC22 domain family, member 3
chr1_+_226271314 8.325


chr2_+_220042963 7.853 FAM134A
family with sequence similarity 134, member A
chr1_+_11866302 7.731 CLCN6
chloride channel 6
chrX_+_102631267 7.695 NM_206915
NM_206917
NGFRAP1

nerve growth factor receptor (TNFRSF16) associated protein 1

chr1_-_26232890 7.633 NM_001145454
NM_005563
STMN1

stathmin 1

chr13_+_113951461 7.500 NM_005561
LAMP1
lysosomal-associated membrane protein 1
chr17_-_47841517 7.490 NM_030802
FAM117A
family with sequence similarity 117, member A
chr1_+_11866240 7.471 CLCN6
chloride channel 6
chr7_+_27225009 7.450 HOXA11-AS1
HOXA11 antisense RNA 1 (non-protein coding)
chr15_-_72668184 7.443 HEXA
hexosaminidase A (alpha polypeptide)
chr17_-_47841468 7.377 FAM117A
family with sequence similarity 117, member A
chr6_+_160390128 7.355 NM_000876
IGF2R
insulin-like growth factor 2 receptor
chr3_+_112280871 7.226 NM_017945
SLC35A5
solute carrier family 35, member A5
chr10_+_25305507 7.082 NM_024838
THNSL1
threonine synthase-like 1 (S. cerevisiae)
chr19_+_14544100 7.075 NM_002741
PKN1
protein kinase N1
chr17_-_62915580 6.965 LRRC37A3
leucine rich repeat containing 37, member A3
chr3_+_112280911 6.965 SLC35A5
solute carrier family 35, member A5
chr16_+_30960434 6.862 ORAI3
ORAI calcium release-activated calcium modulator 3
chr8_-_143484528 6.818 NM_145003
TSNARE1
t-SNARE domain containing 1
chr8_-_71581354 6.809 LACTB2
lactamase, beta 2
chrX_+_101975641 6.787 NM_001142524
NM_001142525
NM_001142526
NM_001142527
NM_001142528
NM_030639
BHLHB9





basic helix-loop-helix domain containing, class B, 9





chr10_+_23728197 6.690 NM_001145373
OTUD1
OTU domain containing 1
chr17_+_78075390 6.614 GAA
glucosidase, alpha; acid
chr16_+_30960413 6.580 ORAI3
ORAI calcium release-activated calcium modulator 3
chr8_-_95961543 6.566 NM_001135733
NM_033285
TP53INP1

tumor protein p53 inducible nuclear protein 1

chr5_-_154230148 6.560 C5orf4
chromosome 5 open reading frame 4
chr16_+_30960377 6.484 NM_152288
ORAI3
ORAI calcium release-activated calcium modulator 3
chr19_-_36545298 6.456 THAP8
THAP domain containing 8
chr17_+_78075299 6.438 NM_000152
NM_001079803
NM_001079804
GAA


glucosidase, alpha; acid


chr17_+_57408907 6.433 NM_001005404
YPEL2
yippee-like 2 (Drosophila)
chr5_-_1112106 6.357 NM_006598
SLC12A7
solute carrier family 12 (potassium/chloride transporters), member 7
chr6_-_84937313 6.345 NM_014895
KIAA1009
KIAA1009
chr9_-_73028278 6.280 KLF9
Kruppel-like factor 9
chr20_-_2821245 6.259 NM_022760
FAM113A
family with sequence similarity 113, member A
chr20_+_44519590 6.252 NM_000308
NM_001127695
NM_001167594
CTSA


cathepsin A


chr19_-_5340700 6.224 NM_002850
NM_130853
NM_130854
NM_130855
PTPRS



protein tyrosine phosphatase, receptor type, S



chr20_-_2821120 6.107 FAM113A
family with sequence similarity 113, member A
chr2_+_220042986 6.080 FAM134A
family with sequence similarity 134, member A
chr5_-_121414011 6.078 NM_002317
LOX
lysyl oxidase
chr22_+_35695872 6.069 TOM1
target of myb1 (chicken)
chr12_+_54447660 5.996 NM_153633
HOXC4
HOXC6
homeobox C4
homeobox C6
chr1_-_26232643 5.991 NM_203401
STMN1
stathmin 1
chr11_+_1330977 5.922 LOC255512
uncharacterized LOC255512
chr2_+_220042901 5.913 NM_024293
FAM134A
family with sequence similarity 134, member A
chr3_-_4508952 5.907 SUMF1
sulfatase modifying factor 1
chr3_-_4508928 5.905 SUMF1
sulfatase modifying factor 1
chr5_-_121413906 5.873 LOX
lysyl oxidase
chr17_-_35969401 5.801 NM_001163544
NM_001163545
NM_001163546
NM_001163547
NM_007247
NM_080550
NM_198882
SYNRG






synergin, gamma






chr3_-_126076057 5.799 NM_014079
KLF15
Kruppel-like factor 15
chr5_-_121413967 5.791 LOX
lysyl oxidase
chr20_+_44519965 5.788 CTSA
cathepsin A
chr11_+_62538774 5.782 NM_006473
TAF6L
TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
chr17_-_46655544 5.736 NM_024015
HOXB4
homeobox B4
chr13_+_52027435 5.732


chr3_-_4508939 5.722 SUMF1
sulfatase modifying factor 1
chr2_+_220042948 5.719 FAM134A
family with sequence similarity 134, member A
chr1_-_154928595 5.669 PBXIP1
pre-B-cell leukemia homeobox interacting protein 1
chrX_-_106960028 5.660 TSC22D3
TSC22 domain family, member 3
chr3_+_23986735 5.620 NM_005126
NR1D2
nuclear receptor subfamily 1, group D, member 2
chr5_-_172198160 5.618 NM_004417
DUSP1
dual specificity phosphatase 1
chrX_-_9733916 5.593 NM_000273
GPR143
G protein-coupled receptor 143
chr1_+_32712817 5.561 NM_032648
FAM167B
family with sequence similarity 167, member B
chr22_-_36903086 5.557 NM_024955
NM_001102371
FOXRED2

FAD-dependent oxidoreductase domain containing 2

chr11_-_71814294 5.497 LAMTOR1
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
chr11_+_118938473 5.486 NM_021729
VPS11
vacuolar protein sorting 11 homolog (S. cerevisiae)
chr19_+_14544216 5.476 PKN1
protein kinase N1
chr7_+_27224163 5.454


chr17_+_78075360 5.450 GAA
glucosidase, alpha; acid
chr9_-_140444835 5.448 NM_001098537
NM_152286
PNPLA7

patatin-like phospholipase domain containing 7

chr1_+_183605207 5.439 NM_015149
RGL1
ral guanine nucleotide dissociation stimulator-like 1
chr20_+_44519924 5.428 CTSA
cathepsin A
chr20_+_44520021 5.403 CTSA
cathepsin A
chr3_-_4508955 5.401 NM_001164674
NM_001164675
NM_182760
SUMF1


sulfatase modifying factor 1


chr2_-_211035377 5.336 C2orf67
chromosome 2 open reading frame 67
chr15_-_34629941 5.329 NM_001042494
NM_001042496
SLC12A6

solute carrier family 12 (potassium/chloride transporters), member 6

chr12_+_54332575 5.296 NM_017410
HOXC13
homeobox C13
chr10_-_46090191 5.256 NM_001002265
NM_145021
MARCH8

membrane-associated ring finger (C3HC4) 8

chr3_-_40350948 5.225 FLJ33065
uncharacterized LOC440952
chr11_-_71814335 5.156 LAMTOR1
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
chr1_-_24513737 5.135 NM_170743
NM_173064
NM_173065
IL28RA


interleukin 28 receptor, alpha (interferon, lambda receptor)


chr12_-_10021932 5.105 CLEC2B
C-type lectin domain family 2, member B
chr1_+_150255228 5.076 NM_144697
C1orf51
chromosome 1 open reading frame 51
chr4_-_175443601 5.033 HPGD
hydroxyprostaglandin dehydrogenase 15-(NAD)
chr15_+_72410630 5.030 NM_001172111
NM_145204
SENP8

SUMO/sentrin specific peptidase family member 8

chr13_+_113951589 5.022 LAMP1
lysosomal-associated membrane protein 1
chr16_+_69984809 5.021 NM_182619
CLEC18C
CLEC18A
C-type lectin domain family 18, member C
C-type lectin domain family 18, member A
chr19_-_40324747 5.013 NM_004714
NM_006483
NM_006484
DYRK1B


dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B


chrX_+_102883891 4.987 NM_001006639
NM_004780
TCEAL1

transcription elongation factor A (SII)-like 1

chr12_-_112450914 4.973 NM_001193453
NM_001193531
NM_138341
LOC728543
TMEM116


uncharacterized LOC728543
transmembrane protein 116


chr16_+_19567021 4.914 C16orf62
chromosome 16 open reading frame 62
chrX_+_105937067 4.907 NM_024539
RNF128
ring finger protein 128
chr8_-_71581419 4.901 NM_016027
LACTB2
lactamase, beta 2
chr11_-_71814371 4.898 NM_017907
LAMTOR1
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
chr8_+_142402108 4.884


chr17_+_42422490 4.867 NM_002087
GRN
granulin
chr22_-_31688329 4.853 NM_001135911
NM_052880
PIK3IP1

phosphoinositide-3-kinase interacting protein 1

chr3_+_44903376 4.817 NM_144638
TMEM42
transmembrane protein 42
chr11_-_71814268 4.773 LAMTOR1
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
chr11_-_1785126 4.760 CTSD
cathepsin D
chr16_-_28503079 4.748 NM_000086
CLN3
ceroid-lipofuscinosis, neuronal 3
chr11_+_7535213 4.719 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr14_-_64970319 4.719 NM_006977
ZBTB25
zinc finger and BTB domain containing 25
chr13_-_33859835 4.718 NM_178006
STARD13
StAR-related lipid transfer (START) domain containing 13
chr19_+_37407230 4.673 NM_001204835
NM_001204836
NM_001204837
NM_001204838
NM_001204839
NM_198539
ZNF568





zinc finger protein 568





chr8_+_26240522 4.648 NM_004331
BNIP3L
BCL2/adenovirus E1B 19kDa interacting protein 3-like
chr20_+_44520203 4.619 CTSA
cathepsin A
chr5_-_139944045 4.614 NM_006051
NM_133172
NM_133173
NM_133174
APBB3



amyloid beta (A4) precursor protein-binding, family B, member 3



chr14_+_76044939 4.598 NM_017791
FLVCR2
feline leukemia virus subgroup C cellular receptor family, member 2
chr1_+_10092990 4.594 NM_001105562
NM_006048
UBE4B

ubiquitination factor E4B

chr11_+_67776016 4.548 NM_001161473
ALDH3B1
aldehyde dehydrogenase 3 family, member B1
chr19_+_49458129 4.541 BAX
BCL2-associated X protein
chr1_+_11796177 4.533 AGTRAP
angiotensin II receptor-associated protein
chr11_-_1785087 4.527 CTSD
cathepsin D
chr1_+_11796128 4.526 NM_001040194
NM_001040195
NM_001040196
NM_001040197
NM_020350
AGTRAP




angiotensin II receptor-associated protein




chr11_+_9595451 4.507 WEE1
WEE1 homolog (S. pombe)
chr13_-_50159706 4.493 NM_018191
RCBTB1
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
chr11_+_118938530 4.489 VPS11
vacuolar protein sorting 11 homolog (S. cerevisiae)
chr11_+_118938528 4.468 VPS11
vacuolar protein sorting 11 homolog (S. cerevisiae)
chr6_+_123110345 4.458 SMPDL3A
sphingomyelin phosphodiesterase, acid-like 3A
chr6_-_31830551 4.428 NEU1
sialidase 1 (lysosomal sialidase)
chr7_-_47621635 4.422 TNS3
tensin 3
chr16_+_5083671 4.422 LOC100507589
uncharacterized LOC100507589
chr11_+_18720342 4.410 NM_153347
TMEM86A
transmembrane protein 86A
chr1_-_202896315 4.400 KLHL12
kelch-like 12 (Drosophila)
chr7_-_47621741 4.391 NM_022748
TNS3
tensin 3
chr15_-_34610928 4.376 NM_005135
SLC12A6
solute carrier family 12 (potassium/chloride transporters), member 6
chr5_-_131132690 4.374 FNIP1
folliculin interacting protein 1
chr1_+_11866206 4.339 NM_001286
NM_021735
NM_021736
NM_021737
CLCN6



chloride channel 6



chr1_-_186649421 4.327 NM_000963
PTGS2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
chr12_-_110505499 4.308 NM_207435
C12orf76
chromosome 12 open reading frame 76
chr17_+_42977141 4.299 NM_213607
CCDC103
coiled-coil domain containing 103
chr18_+_44497512 4.288 KATNAL2
katanin p60 subunit A-like 2
chr15_+_72410724 4.287 SENP8
SUMO/sentrin specific peptidase family member 8
chr11_+_118938515 4.284 VPS11
vacuolar protein sorting 11 homolog (S. cerevisiae)
chr11_-_1785104 4.279 CTSD
cathepsin D
chr1_-_204329043 4.269 NM_014935
PLEKHA6
pleckstrin homology domain containing, family A member 6
chr1_+_11796211 4.258 AGTRAP
angiotensin II receptor-associated protein
chr11_+_9595429 4.245 WEE1
WEE1 homolog (S. pombe)
chr11_+_7535000 4.240 NM_003621
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr6_+_31982538 4.234 NM_001242823
NM_001252204
NM_007293
NM_001002029
LOC100293534
C4A

C4B
complement C4-B-like
complement component 4A (Rodgers blood group)

complement component 4B (Chido blood group)
chr13_-_50159628 4.222 RCBTB1
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
chr12_-_92539614 4.215 NM_001731
BTG1
B-cell translocation gene 1, anti-proliferative
chr1_+_201476283 4.213


chr1_-_155211049 4.210 NM_001171812
NM_000157
GBA

glucosidase, beta, acid

chr3_+_113465860 4.193 NM_001690
ATP6V1A
ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
chr7_-_29186072 4.187 NM_019029
NM_031311
CPVL

carboxypeptidase, vitellogenic-like

chr2_-_220083394 4.183 ABCB6
ATP-binding cassette, sub-family B (MDR/TAP), member 6
chr10_+_69644708 4.181 SIRT1
sirtuin 1
chr15_-_72668740 4.181 HEXA
hexosaminidase A (alpha polypeptide)
chr12_-_65153182 4.177 GNS
glucosamine (N-acetyl)-6-sulfatase
chr19_-_12886421 4.174 NM_001100176
NM_013312
HOOK2

hook homolog 2 (Drosophila)

chr1_-_26233367 4.109 NM_203399
STMN1
stathmin 1
chr17_+_46019022 4.097 PNPO
pyridoxamine 5'-phosphate oxidase
chr1_-_45956795 4.091 NM_007170
TESK2
testis-specific kinase 2
chr22_+_35695792 4.072 NM_001135730
NM_001135732
NM_005488
TOM1


target of myb1 (chicken)


chr4_-_164253946 4.051 NM_000909
NPY1R
neuropeptide Y receptor Y1
chr19_+_49458151 4.044 BAX
BCL2-associated X protein
chr12_+_53400245 4.001 EIF4B
eukaryotic translation initiation factor 4B
chr2_+_85980600 4.001 NM_032827
ATOH8
atonal homolog 8 (Drosophila)
chr17_+_79935493 4.001 ASPSCR1
alveolar soft part sarcoma chromosome region, candidate 1
chr17_+_48172508 3.988 NM_001199900
NM_002611
NM_001199899
PDK2


pyruvate dehydrogenase kinase, isozyme 2


chrX_-_101397370 3.984 NM_001006938
TCEAL6
transcription elongation factor A (SII)-like 6
chr11_-_17035948 3.978 NM_175058
PLEKHA7
pleckstrin homology domain containing, family A member 7
chr5_-_150537306 3.951 ANXA6
annexin A6
chr19_-_36545646 3.950 NM_152658
THAP8
THAP domain containing 8
chr16_-_28503622 3.950 NM_001042432
CLN3
ceroid-lipofuscinosis, neuronal 3
chr22_-_36903033 3.942 FOXRED2
FAD-dependent oxidoreductase domain containing 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
12.09 9.20e-03 GO:0071418 cellular response to amine stimulus
11.38 1.38e-02 GO:0071417 cellular response to organic nitrogen
8.36 2.39e-02 GO:0007040 lysosome organization
6.04 2.48e-02 GO:0007033 vacuole organization
1.62 4.99e-02 GO:0006996 organelle organization

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
4.19 4.64e-12 GO:0005773 vacuole
5.84 3.00e-11 GO:0005774 vacuolar membrane
4.32 8.17e-11 GO:0000323 lytic vacuole
4.32 8.17e-11 GO:0005764 lysosome
5.58 9.53e-11 GO:0044437 vacuolar part
6.50 1.92e-10 GO:0005765 lysosomal membrane
1.34 1.75e-05 GO:0044444 cytoplasmic part
1.15 1.41e-04 GO:0005622 intracellular
1.16 2.40e-04 GO:0044424 intracellular part
1.23 3.97e-04 GO:0005737 cytoplasm
1.19 4.30e-04 GO:0043226 organelle
1.21 4.99e-04 GO:0043227 membrane-bounded organelle
1.20 1.04e-03 GO:0043231 intracellular membrane-bounded organelle
1.31 1.17e-03 GO:0044446 intracellular organelle part
1.18 1.28e-03 GO:0043229 intracellular organelle
1.30 1.45e-03 GO:0044422 organelle part
3.99 2.57e-02 GO:0042470 melanosome
3.99 2.57e-02 GO:0048770 pigment granule

Nothing significant found in function category.