Motif ID: SPZ1.p2

Z-value: 1.576


Transcription factors associated with SPZ1.p2:

Gene SymbolEntrez IDGene Name
SPZ1 84654 spermatogenic leucine zipper 1



Activity profile for motif SPZ1.p2.

activity profile for motif SPZ1.p2


Sorted Z-values histogram for motif SPZ1.p2

Sorted Z-values for motif SPZ1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SPZ1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_57976550 16.738 NM_001253835
NM_001553
IGFBP7

insulin-like growth factor binding protein 7

chr17_-_40264687 15.666 NM_024119
DHX58
DEXH (Asp-Glu-X-His) box polypeptide 58
chr2_+_30454396 14.830 NM_030915
LBH
limb bud and heart development homolog (mouse)
chr2_+_228029280 11.895 NM_000091
COL4A3
collagen, type IV, alpha 3 (Goodpasture antigen)
chr17_-_27949814 11.805 CORO6
coronin 6
chr4_-_57976516 10.697 IGFBP7
insulin-like growth factor binding protein 7
chr14_+_24867926 9.902 NM_025081
NYNRIN
NYN domain and retroviral integrase containing
chrX_-_51239295 9.367 NUDT11
nudix (nucleoside diphosphate linked moiety X)-type motif 11
chr20_+_44746948 9.139 CD40
CD40 molecule, TNF receptor superfamily member 5
chr12_+_57998600 8.979 NM_178502
DTX3
deltex homolog 3 (Drosophila)
chr1_-_41950296 8.972 NM_001956
EDN2
endothelin 2
chr20_+_44746889 8.743 NM_001250
NM_152854
CD40

CD40 molecule, TNF receptor superfamily member 5

chr19_+_41281281 8.509 NM_006533
MIA
melanoma inhibitory activity
chr3_+_8543508 8.395 NM_014583
LMCD1
LIM and cysteine-rich domains 1
chr5_-_151066492 7.789 NM_003118
SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chr2_-_228029274 7.614 NM_000092
COL4A4
collagen, type IV, alpha 4
chr4_-_83483099 7.612 NM_001080506
TMEM150C
transmembrane protein 150C
chr12_+_58005217 7.598 NM_182947
ARHGEF25
Rho guanine nucleotide exchange factor (GEF) 25
chr16_+_2039945 7.575 NM_004209
SYNGR3
synaptogyrin 3
chr4_-_57976355 7.494 IGFBP7
insulin-like growth factor binding protein 7
chrX_-_51239426 7.361 NM_018159
NUDT11
nudix (nucleoside diphosphate linked moiety X)-type motif 11
chr13_-_49107185 6.961 RCBTB2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr1_+_92495484 6.653 NM_173567
EPHX4
epoxide hydrolase 4
chrX_+_105969875 6.443 NM_194463
RNF128
ring finger protein 128
chr17_-_19770988 6.378 NM_001142610
NM_014683
ULK2

unc-51-like kinase 2 (C. elegans)

chr5_-_151066445 6.321 SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chr1_-_115632047 6.268 NM_005725
TSPAN2
tetraspanin 2
chr19_-_41934634 6.137 NM_198540
B3GNT8
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8
chr16_+_30907927 6.068 NM_001142544
NM_001330
CTF1

cardiotrophin 1

chr1_-_182360400 6.037 NM_001033056
GLUL
glutamate-ammonia ligase
chr16_+_4838397 5.976 NM_001253790
NM_001253791
LOC440335

uncharacterized LOC440335

chr16_+_82660573 5.797 CDH13
cadherin 13, H-cadherin (heart)
chr10_-_118429469 5.767 NM_144661
C10orf82
chromosome 10 open reading frame 82
chr17_+_38599651 5.692 NM_001552
IGFBP4
insulin-like growth factor binding protein 4
chr11_+_43963809 5.603 NM_001145033
C11orf96
chromosome 11 open reading frame 96
chr1_+_164528914 5.563 PBX1
pre-B-cell leukemia homeobox 1
chr1_+_154300275 5.403 NM_020452
ATP8B2
ATPase, class I, type 8B, member 2
chr20_-_25038501 5.343 NM_001252675
NM_001252677
NM_032501
ACSS1


acyl-CoA synthetase short-chain family member 1


chr6_-_32160289 5.287 GPSM3
G-protein signaling modulator 3
chr13_+_42031525 5.267 NM_014059
C13orf15
chromosome 13 open reading frame 15
chr1_+_164528586 5.236 NM_001204961
NM_001204963
NM_002585
PBX1


pre-B-cell leukemia homeobox 1


chr2_-_160918935 5.175 PLA2R1
phospholipase A2 receptor 1, 180kDa
chr9_+_12775713 5.167 C9orf150
chromosome 9 open reading frame 150
chr12_+_569542 5.135 NM_173593
B4GALNT3
beta-1,4-N-acetyl-galactosaminyl transferase 3
chr22_+_38201232 5.032 H1F0
H1 histone family, member 0
chr3_+_49208979 5.018 NM_173546
KLHDC8B
kelch domain containing 8B
chr15_-_45480160 5.014 SHF
Src homology 2 domain containing F
chr16_+_82660390 4.996 NM_001220488
NM_001220489
NM_001220490
NM_001220491
NM_001220492
NM_001257
CDH13





cadherin 13, H-cadherin (heart)





chr11_+_46402333 4.989 NM_001012334
MDK
midkine (neurite growth-promoting factor 2)
chr14_-_60337350 4.983 NM_021136
RTN1
reticulon 1
chr14_+_24838301 4.889 NM_001198966
NFATC4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
chr3_-_48632592 4.879 NM_000094
COL7A1
collagen, type VII, alpha 1
chr1_-_110933635 4.852 SLC16A4
solute carrier family 16, member 4 (monocarboxylic acid transporter 5)
chr16_+_82660641 4.771 CDH13
cadherin 13, H-cadherin (heart)
chr10_+_63422718 4.699 NM_173554
C10orf107
chromosome 10 open reading frame 107
chr2_+_37571752 4.676 NM_012413
QPCT
glutaminyl-peptide cyclotransferase
chr9_-_34522972 4.672 NM_198573
ENHO
energy homeostasis associated
chr18_+_21269528 4.651 NM_001127717
NM_198129
LAMA3

laminin, alpha 3

chr6_+_19837599 4.470 NM_001546
ID4
inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
chr4_-_77819001 4.435 NM_001029870
ANKRD56
ankyrin repeat domain 56
chr11_+_118401755 4.405 NM_001144034
NM_001144035
NM_001144036
NM_001144037
NM_001144038
NM_032780
TMEM25





transmembrane protein 25





chr17_-_42200957 4.361 HDAC5
histone deacetylase 5
chr2_-_216300770 4.351 NM_002026
NM_054034
NM_212474
NM_212476
NM_212478
NM_212482
FN1





fibronectin 1





chr13_+_42031690 4.349 C13orf15
chromosome 13 open reading frame 15
chr5_+_140306301 4.339 NM_018898
NM_031882
PCDHAC1

protocadherin alpha subfamily C, 1

chr2_+_71680752 4.336 NM_001130976
NM_001130977
NM_001130978
NM_001130979
NM_001130980
NM_001130981
NM_003494
DYSF






dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)






chr12_+_111471827 4.324 NM_015267
CUX2
cut-like homeobox 2
chr17_-_39890882 4.312 NM_001079870
NM_001079871
NM_177977
HAP1


huntingtin-associated protein 1


chr10_-_50970321 4.280 NM_001143996
NM_001143997
NM_018245
OGDHL


oxoglutarate dehydrogenase-like


chr1_+_154301219 4.263 ATP8B2
ATPase, class I, type 8B, member 2
chr6_-_32160637 4.250 GPSM3
G-protein signaling modulator 3
chr6_-_36164973 4.238


chr10_+_64133915 4.213 NM_014951
NM_199450
NM_199451
ZNF365


zinc finger protein 365


chr5_+_76011780 4.203 NM_001992
F2R
coagulation factor II (thrombin) receptor
chr5_+_140777603 4.191 NM_018925
NM_032099
PCDHGB5

protocadherin gamma subfamily B, 5

chr19_-_58514136 4.191 ZNF606
zinc finger protein 606
chr3_+_8543539 4.167 LMCD1
LIM and cysteine-rich domains 1
chr3_-_139396773 4.127 NM_001200047
NM_178177
NMNAT3

nicotinamide nucleotide adenylyltransferase 3

chr2_-_182521732 4.117 NM_001030311
NM_001030312
NM_001030313
NM_001160277
NM_201548
CERKL




ceramide kinase-like




chr2_+_182321933 4.110 ITGA4
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
chr1_-_182361311 4.107 NM_001033044
NM_002065
GLUL

glutamate-ammonia ligase

chr6_-_116381765 4.092 NM_002031
FRK
fyn-related kinase
chr20_+_327329 4.067 NM_024958
NRSN2
neurensin 2
chr17_+_7452374 4.035 NM_172089
NM_003809
TNFSF12-TNFSF13
TNFSF12
TNFSF12-TNFSF13 readthrough
tumor necrosis factor (ligand) superfamily, member 12
chr22_+_38201300 3.997 H1F0
H1 histone family, member 0
chr10_-_44144266 3.985 NM_006973
ZNF32
zinc finger protein 32
chr6_+_31430955 3.955 HCP5
HLA complex P5 (non-protein coding)
chr8_-_22550456 3.936 EGR3
early growth response 3
chr8_-_22550057 3.913 NM_001199881
EGR3
early growth response 3
chr6_-_11382501 3.913 NM_001142393
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr5_-_149682447 3.912 NM_001012301
ARSI
arylsulfatase family, member I
chr12_-_112450914 3.862 NM_001193453
NM_001193531
NM_138341
LOC728543
TMEM116


uncharacterized LOC728543
transmembrane protein 116


chr3_-_197282805 3.842 NM_004051
NM_203314
BDH1

3-hydroxybutyrate dehydrogenase, type 1

chr13_-_49107250 3.822 NM_001268
RCBTB2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr12_+_49740688 3.821 DNAJC22
DnaJ (Hsp40) homolog, subfamily C, member 22
chr14_-_90085325 3.802 NM_001085471
FOXN3
forkhead box N3
chr19_+_48828627 3.801 NM_001425
EMP3
epithelial membrane protein 3
chrX_+_55478537 3.777 NM_014061
MAGEH1
melanoma antigen family H, 1
chr19_+_17581276 3.725 NM_198580
SLC27A1
solute carrier family 27 (fatty acid transporter), member 1
chr20_-_62130390 3.692 NM_001958
EEF1A2
eukaryotic translation elongation factor 1 alpha 2
chr2_-_70314065 3.681 PCBP1-AS1
PCBP1 antisense RNA 1 (non-protein coding)
chrX_+_84498993 3.673 NM_021998
ZNF711
zinc finger protein 711
chr1_-_151118932 3.669 NM_001178061
NM_001178062
NM_030913
SEMA6C


sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C


chrX_-_48693934 3.593 NM_013271
PCSK1N
proprotein convertase subtilisin/kexin type 1 inhibitor
chr11_+_33061291 3.534 TCP11L1
t-complex 11 (mouse)-like 1
chr1_-_183387404 3.472


chr1_-_156265395 3.457 NM_144580
C1orf85
chromosome 1 open reading frame 85
chr13_-_113344050 3.441 LOC440149
uncharacterized LOC440149
chr15_-_34629941 3.428 NM_001042494
NM_001042496
SLC12A6

solute carrier family 12 (potassium/chloride transporters), member 6

chr8_-_91997437 3.405 NM_001190972
LOC100127983
uncharacterized LOC100127983
chr3_-_18466759 3.402 NM_001195470
NM_002971
SATB1

SATB homeobox 1

chr14_-_23652840 3.393 NM_012244
SLC7A8
solute carrier family 7 (amino acid transporter light chain, L system), member 8
chr10_-_105212149 3.384 NM_015916
CALHM2
calcium homeostasis modulator 2
chr4_-_84256012 3.379 NM_001098540
HPSE
heparanase
chr11_+_19734821 3.376 NM_001244963
NM_145117
NM_182964
NAV2


neuron navigator 2


chr2_-_26205327 3.361 KIF3C
kinesin family member 3C
chr8_+_117950437 3.352 NM_001025357
C8orf85
chromosome 8 open reading frame 85
chr2_-_160919120 3.314 NM_001007267
NM_001195641
NM_007366
PLA2R1


phospholipase A2 receptor 1, 180kDa


chr11_-_57283145 3.271 NM_003627
SLC43A1
solute carrier family 43, member 1
chr5_+_121647773 3.251 NM_001242935
NM_005460
SNCAIP

synuclein, alpha interacting protein

chr10_-_62703822 3.249 NM_001242359
NM_014836
RHOBTB1

Rho-related BTB domain containing 1

chr12_+_52416615 3.249 NM_001202233
NR4A1
nuclear receptor subfamily 4, group A, member 1
chr10_-_116164514 3.242 NM_001001936
NM_032550
AFAP1L2

actin filament associated protein 1-like 2

chr20_+_33134691 3.231 NM_181509
MAP1LC3A
microtubule-associated protein 1 light chain 3 alpha
chr17_+_73584138 3.224 MYO15B
myosin XVB pseudogene
chr12_+_57522247 3.220 NM_002332
LRP1
low density lipoprotein receptor-related protein 1
chr1_-_110933683 3.214 NM_001201546
NM_001201547
NM_001201548
NM_001201549
NM_004696
SLC16A4




solute carrier family 16, member 4 (monocarboxylic acid transporter 5)




chr1_+_206730497 3.199 RASSF5
Ras association (RalGDS/AF-6) domain family member 5
chr10_-_105212022 3.198 CALHM2
calcium homeostasis modulator 2
chr19_+_48828820 3.164 EMP3
epithelial membrane protein 3
chr3_-_190040192 3.157 NM_021101
CLDN1
claudin 1
chr11_-_6440288 3.150 NM_001164
APBB1
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
chr16_+_222845 3.147 NM_000517
HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr19_-_17007674 3.113 CPAMD8
C3 and PZP-like, alpha-2-macroglobulin domain containing 8
chr1_+_206730456 3.111 NM_182665
RASSF5
Ras association (RalGDS/AF-6) domain family member 5
chr18_-_28681885 3.091 NM_004949
NM_024422
DSC2

desmocollin 2

chr15_-_34630203 3.087 NM_001042495
SLC12A6
solute carrier family 12 (potassium/chloride transporters), member 6
chr15_-_48470453 3.083 NM_016132
MYEF2
myelin expression factor 2
chr12_+_79258448 3.083 NM_005639
SYT1
synaptotagmin I
chr2_-_216300444 3.082 FN1
fibronectin 1
chr11_+_65554566 3.080 OVOL1
ovo-like 1(Drosophila)
chr1_+_10057254 3.077 NM_052960
RBP7
retinol binding protein 7, cellular
chr14_-_91526912 3.025 NM_004755
NM_182398
RPS6KA5

ribosomal protein S6 kinase, 90kDa, polypeptide 5

chr11_+_33061560 3.022 NM_001145541
TCP11L1
t-complex 11 (mouse)-like 1
chr3_-_171528227 3.021 NM_001130081
NM_002662
PLD1

phospholipase D1, phosphatidylcholine-specific

chr11_+_64067862 3.013 NM_001039496
C11orf20
chromosome 11 open reading frame 20
chr1_-_24513737 3.009 NM_170743
NM_173064
NM_173065
IL28RA


interleukin 28 receptor, alpha (interferon, lambda receptor)


chr20_-_56884488 2.994 PPP4R1L
protein phosphatase 4, regulatory subunit 1-like
chr17_-_42466840 2.987 NM_000419
ITGA2B
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
chr11_+_65554504 2.984 NM_004561
OVOL1
ovo-like 1(Drosophila)
chr9_-_86571533 2.982 C9orf64
chromosome 9 open reading frame 64
chr9_+_12774988 2.981 NM_203403
C9orf150
chromosome 9 open reading frame 150
chr12_-_110252600 2.956 NM_001177431
NM_001177428
NM_001177433
NM_147204
TRPV4



transient receptor potential cation channel, subfamily V, member 4



chr19_-_50979461 2.938 FAM71E1
family with sequence similarity 71, member E1
chr2_+_33172368 2.937 NM_206943
LTBP1
latent transforming growth factor beta binding protein 1
chr8_-_22550708 2.932 NM_004430
EGR3
early growth response 3
chr6_+_89790464 2.921 PNRC1
proline-rich nuclear receptor coactivator 1
chr17_-_39216343 2.916 NM_001165252
LOC730755
keratin associated protein 2-4-like
chr10_+_17270257 2.906 NM_003380
VIM
vimentin
chr15_+_48010685 2.903 NM_020858
NM_024966
NM_153616
NM_153617
NM_153618
NM_153619
SEMA6D





sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D





chr19_+_47524142 2.901 NM_002517
NPAS1
neuronal PAS domain protein 1
chr3_-_158450205 2.900 RARRES1
retinoic acid receptor responder (tazarotene induced) 1
chr1_-_182360181 2.887 GLUL
glutamate-ammonia ligase
chr17_-_48546174 2.884 NM_001267
CHAD
chondroadherin
chr17_+_64960754 2.880 NM_014405
CACNG4
calcium channel, voltage-dependent, gamma subunit 4
chr11_-_94964209 2.878 NM_144665
SESN3
sestrin 3
chr17_-_42201009 2.866 NM_001015053
NM_005474
HDAC5

histone deacetylase 5

chr3_+_111718006 2.866 NM_001008273
TAGLN3
transgelin 3
chr15_+_65903569 2.862 SLC24A1
solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
chr11_+_6411637 2.861 NM_000543
NM_001007593
SMPD1

sphingomyelin phosphodiesterase 1, acid lysosomal

chr12_+_6420098 2.856 NM_001144856
PLEKHG6
pleckstrin homology domain containing, family G (with RhoGef domain) member 6
chr5_-_131347249 2.854 NM_001009185
NM_001205247
NM_015256
ACSL6


acyl-CoA synthetase long-chain family member 6


chr3_+_69788562 2.853 NM_198159
MITF
microphthalmia-associated transcription factor
chr6_+_126111782 2.846 NM_001122842
NM_001199621
NM_181782
NCOA7


nuclear receptor coactivator 7


chr14_-_23821423 2.832 NM_020372
SLC22A17
solute carrier family 22, member 17
chr17_+_4046417 2.826 NM_144611
CYB5D2
cytochrome b5 domain containing 2
chr10_+_95753684 2.815 NM_016341
PLCE1
phospholipase C, epsilon 1
chr20_-_25566137 2.813 NM_025176
NINL
ninein-like
chr3_-_50605062 2.813 NM_001171740
NM_001171743
NM_016210
C3orf18


chromosome 3 open reading frame 18


chr12_-_22487566 2.798 NM_003034
ST8SIA1
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
chr8_-_22089850 2.798 NM_001099335
NM_014759
PHYHIP

phytanoyl-CoA 2-hydroxylase interacting protein

chr19_-_6720585 2.793 NM_000064
C3
complement component 3
chrX_+_51075667 2.793 NUDT10
nudix (nucleoside diphosphate linked moiety X)-type motif 10
chr1_-_156265457 2.779 C1orf85
chromosome 1 open reading frame 85
chr19_-_43690558 2.777 NM_001130014
NM_002781
PSG5

pregnancy specific beta-1-glycoprotein 5

chr12_+_56732658 2.772 NM_016584
IL23A
interleukin 23, alpha subunit p19
chr6_-_89827605 2.758 NM_080743
SRSF12
serine/arginine-rich splicing factor 12
chr14_-_23652818 2.745 SLC7A8
solute carrier family 7 (amino acid transporter light chain, L system), member 8
chrX_-_133119475 2.734 GPC3
glypican 3
chr11_+_86511490 2.734 NM_007173
PRSS23
protease, serine, 23
chr12_+_57522429 2.727 LRP1
low density lipoprotein receptor-related protein 1
chr11_+_118401873 2.724 TMEM25
transmembrane protein 25
chr4_-_84255999 2.714 HPSE
heparanase
chr5_+_42548314 2.707 NM_001242403
GHR
growth hormone receptor
chr10_+_119806334 2.706 CASC2
cancer susceptibility candidate 2 (non-protein coding)
chr10_+_89419352 2.683 NM_001015880
NM_004670
PAPSS2

3'-phosphoadenosine 5'-phosphosulfate synthase 2

chr11_+_121322848 2.679 NM_003105
SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr12_-_62586547 2.677 NM_178539
FAM19A2
family with sequence similarity 19 (chemokine (C-C motif)-like), member A2
chr4_+_106816627 2.675 NPNT
nephronectin
chr7_+_63774378 2.668 ZNF736
zinc finger protein 736

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.35 2.99e-02 GO:0032502 developmental process

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
2.25 1.52e-02 GO:0031012 extracellular matrix
4.15 3.60e-02 GO:0005604 basement membrane
2.28 4.29e-02 GO:0005578 proteinaceous extracellular matrix

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
1.94 1.24e-02 GO:0005509 calcium ion binding