Motif ID: SOX5.p2

Z-value: 1.144


Transcription factors associated with SOX5.p2:

Gene SymbolEntrez IDGene Name
SOX5 6660 SRY (sex determining region Y)-box 5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SOX5hg19_v1_chr12_-_24103842_241038660.522.1e-06Click!


Activity profile for motif SOX5.p2.

activity profile for motif SOX5.p2


Sorted Z-values histogram for motif SOX5.p2

Sorted Z-values for motif SOX5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX5.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_-_82395401 10.575 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr6_+_126070813 7.514 HEY2
hairy/enhancer-of-split related with YRPW motif 2
chr6_+_126070895 7.087 HEY2
hairy/enhancer-of-split related with YRPW motif 2
chr12_-_45270071 6.426 NELL2
NEL-like 2 (chicken)
chr18_-_45663667 6.278 NM_001039360
ZBTB7C
zinc finger and BTB domain containing 7C
chr3_+_89156804 5.703 EPHA3
EPH receptor A3
chr11_-_16424391 5.672 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr11_-_26593667 5.655 NM_001135091
NM_001135092
NM_145650
MUC15


mucin 15, cell surface associated


chr13_+_53602829 5.373 NM_006418
OLFM4
olfactomedin 4
chr19_-_51472816 5.315 NM_002774
KLK6
kallikrein-related peptidase 6
chr3_+_151488214 5.118 LOC201651
arylacetamide deacetylase (esterase) pseudogene
chr6_+_105404922 5.103 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr2_+_169923531 5.050 NM_199204
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr2_+_166428845 4.974 NM_024969
CSRNP3
cysteine-serine-rich nuclear protein 3
chr17_+_54230835 4.718 NM_153228
ANKFN1
ankyrin-repeat and fibronectin type III domain containing 1
chr11_+_112831968 4.397 NM_000615
NM_001076682
NM_001242607
NM_001242608
NM_181351
NCAM1




neural cell adhesion molecule 1




chr6_+_126070724 4.360 NM_012259
HEY2
hairy/enhancer-of-split related with YRPW motif 2
chrX_-_151619669 4.053 NM_000808
GABRA3
gamma-aminobutyric acid (GABA) A receptor, alpha 3
chr6_+_126070738 4.011 HEY2
hairy/enhancer-of-split related with YRPW motif 2
chr7_+_80267782 3.950 NM_000072
NM_001001548
CD36

CD36 molecule (thrombospondin receptor)

chr18_-_31158150 3.894


chrY_+_15016018 3.872 NM_001122665
DDX3Y
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr3_+_89156673 3.870 NM_005233
NM_182644
EPHA3

EPH receptor A3

chr2_-_21230572 3.817 APOB
apolipoprotein B (including Ag(x) antigen)
chr12_-_10282680 3.757 NM_022570
NM_197947
NM_197948
NM_197949
NM_197950
NM_197954
CLEC7A





C-type lectin domain family 7, member A





chr1_+_198608244 3.675 PTPRC
protein tyrosine phosphatase, receptor type, C
chr10_+_101542460 3.614 NM_000392
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr3_+_121613170 3.609 NM_001145998
NM_021082
SLC15A2

solute carrier family 15 (H+/peptide transporter), member 2

chr11_+_112832089 3.597 NCAM1
neural cell adhesion molecule 1
chr17_-_37764165 3.534 NM_006160
NEUROD2
neurogenic differentiation 2
chr3_+_147111221 3.461


chr2_+_171034654 3.454 NM_001083615
NM_001171642
NM_138995
MYO3B


myosin IIIB


chr1_+_153003677 3.430 NM_003125
SPRR1B
small proline-rich protein 1B
chr20_-_61002588 3.413 NM_080833
C20orf151
chromosome 20 open reading frame 151
chr13_-_84456473 3.408 NM_052910
SLITRK1
SLIT and NTRK-like family, member 1
chr13_-_84456424 3.395 SLITRK1
SLIT and NTRK-like family, member 1
chr3_+_130279177 3.355 NM_001102608
COL6A6
collagen, type VI, alpha 6
chr21_+_43619798 3.348 NM_207627
NM_207628
ABCG1

ATP-binding cassette, sub-family G (WHITE), member 1

chr1_+_198608216 3.309 PTPRC
protein tyrosine phosphatase, receptor type, C
chr10_+_11206928 3.288 NM_001025076
NM_001083591
CELF2

CUGBP, Elav-like family member 2

chr1_-_152539228 3.176 NM_178435
LCE3E
late cornified envelope 3E
chr16_+_67381252 3.170 NM_001161575
LRRC36
leucine rich repeat containing 36
chr3_+_171561138 3.131 NM_001164436
TMEM212
transmembrane protein 212
chr11_-_35440514 3.124 SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr1_+_198608136 3.025 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr12_+_69742130 3.000 NM_000239
LYZ
lysozyme
chr3_-_114790221 2.998 NM_001164343
ZBTB20
zinc finger and BTB domain containing 20
chr11_+_112832281 2.969 NCAM1
neural cell adhesion molecule 1
chr6_+_21666645 2.890 LINC00340
long intergenic non-protein coding RNA 340
chr7_-_99381703 2.882 NM_001202855
NM_017460
CYP3A4

cytochrome P450, family 3, subfamily A, polypeptide 4

chr17_+_67498391 2.870 MAP2K6
mitogen-activated protein kinase kinase 6
chr12_-_45270157 2.854 NM_001145108
NM_006159
NELL2

NEL-like 2 (chicken)

chr1_-_53238341 2.790


chr21_-_31588242 2.782 NM_199328
CLDN8
claudin 8
chr20_+_17207680 2.772 PCSK2
proprotein convertase subtilisin/kexin type 2
chr7_+_129932973 2.757 NM_001163446
NM_016352
CPA4

carboxypeptidase A4

chr12_-_8815266 2.752 MFAP5
microfibrillar associated protein 5
chr12_+_69742140 2.726 LYZ
lysozyme
chr11_+_112832201 2.720 NCAM1
neural cell adhesion molecule 1
chr4_+_110749149 2.703 NM_006583
RRH
retinal pigment epithelium-derived rhodopsin homolog
chr2_-_39456672 2.690 NM_001009565
CDKL4
cyclin-dependent kinase-like 4
chr1_-_31230594 2.678 LAPTM5
lysosomal protein transmembrane 5
chr2_-_21233930 2.668 APOB
apolipoprotein B (including Ag(x) antigen)
chrX_-_54824672 2.665 NM_198510
ITIH6
inter-alpha-trypsin inhibitor heavy chain family, member 6
chr3_+_25469833 2.660 NM_000965
RARB
retinoic acid receptor, beta
chr1_-_152086555 2.654 NM_007113
TCHH
trichohyalin
chrX_-_110654373 2.650 NM_000555
DCX
doublecortin
chr6_-_139613114 2.639 NM_153235
TXLNB
taxilin beta
chrX_-_142723921 2.627 NM_001184749
SLITRK4
SLIT and NTRK-like family, member 4
chr8_-_93075190 2.626 NM_004349
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr8_+_104831415 2.605 NM_014677
RIMS2
regulating synaptic membrane exocytosis 2
chr1_-_50889102 2.588 NM_032110
DMRTA2
DMRT-like family A2
chr1_+_163038564 2.584 NM_005613
RGS4
regulator of G-protein signaling 4
chr3_-_58652469 2.573 NM_138805
FAM3D
family with sequence similarity 3, member D
chrX_+_78003205 2.544 NM_005296
LPAR4
lysophosphatidic acid receptor 4
chr8_+_24151579 2.538 NM_014265
NM_021777
ADAM28

ADAM metallopeptidase domain 28

chr3_-_128294928 2.489 NM_007354
C3orf27
chromosome 3 open reading frame 27
chr18_+_28898051 2.480 NM_001942
DSG1
desmoglein 1
chrX_+_9432980 2.475 NM_005647
TBL1X
transducin (beta)-like 1X-linked
chr12_-_24715349 2.446 NM_152989
SOX5
SRY (sex determining region Y)-box 5
chr1_+_156589085 2.438 NM_021817
HAPLN2
hyaluronan and proteoglycan link protein 2
chr6_+_100054649 2.437 NM_021620
PRDM13
PR domain containing 13
chr2_+_217498082 2.409 NM_000597
IGFBP2
insulin-like growth factor binding protein 2, 36kDa
chr1_-_49242406 2.407 NM_024603
BEND5
BEN domain containing 5
chr10_+_101542554 2.403 ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr1_-_193155723 2.394 NM_003783
B3GALT2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr18_+_61254533 2.390 NM_012397
SERPINB13
serpin peptidase inhibitor, clade B (ovalbumin), member 13
chr6_-_32557431 2.388 NM_001243965
NM_002124
HLA-DRB1

HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1

major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr9_+_117904096 2.381 NM_017418
DEC1
deleted in esophageal cancer 1
chr3_+_181429711 2.381 NM_003106
SOX2
SRY (sex determining region Y)-box 2
chr12_-_45269953 2.370 NELL2
NEL-like 2 (chicken)
chr12_-_45307710 2.359 NM_001145110
NELL2
NEL-like 2 (chicken)
chr3_+_25469749 2.355 NM_016152
RARB
retinoic acid receptor, beta
chr2_+_166326156 2.327 NM_001172173
CSRNP3
cysteine-serine-rich nuclear protein 3
chr1_+_153232178 2.315 NM_000427
LOR
loricrin
chr12_+_52445185 2.286 NM_002135
NM_173157
NR4A1

nuclear receptor subfamily 4, group A, member 1

chr4_-_65275000 2.276 NM_001010874
TECRL
trans-2,3-enoyl-CoA reductase-like
chr8_-_102803178 2.272 NCALD
neurocalcin delta
chr12_+_93096618 2.241 NM_001037671
NM_001178097
C12orf74

chromosome 12 open reading frame 74

chr8_-_70745403 2.234 NM_001146009
SLCO5A1
solute carrier organic anion transporter family, member 5A1
chrX_-_112084006 2.222 NM_133265
AMOT
angiomotin
chr7_+_30960914 2.214 NM_001185060
NM_001185061
NM_001185062
AQP1


aquaporin 1 (Colton blood group)


chr1_-_153363544 2.206 NM_002964
S100A8
S100 calcium binding protein A8
chr8_-_72274466 2.168 NM_000503
EYA1
eyes absent homolog 1 (Drosophila)
chr2_-_225266710 2.166 NM_001122779
NM_024785
FAM124B

family with sequence similarity 124B

chr2_-_99871569 2.164 NM_175735
LYG2
lysozyme G-like 2
chr11_-_115375065 2.155 NM_001098517
NM_014333
CADM1

cell adhesion molecule 1

chr12_-_8815479 2.150 MFAP5
microfibrillar associated protein 5
chr1_-_57285368 2.150 NM_001004303
C1orf168
chromosome 1 open reading frame 168
chr4_-_174450529 2.146 HAND2
heart and neural crest derivatives expressed 2
chr18_+_52258389 2.144 NM_173629
C18orf26
chromosome 18 open reading frame 26
chr20_-_3762060 2.144 NM_015417
SPEF1
sperm flagellar 1
chr20_-_7921068 2.122 NM_017545
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr11_-_6817013 2.102 NM_003696
OR6A2
olfactory receptor, family 6, subfamily A, member 2
chr12_-_53207843 2.100 NM_002272
KRT4
keratin 4
chr11_-_123848397 2.099 NM_001004474
OR10S1
olfactory receptor, family 10, subfamily S, member 1
chr13_+_113301357 2.083 NM_207440
C13orf35
chromosome 13 open reading frame 35
chr17_-_46671322 2.081 HOXB5
homeobox B5
chr11_+_109292837 2.078 NM_207645
C11orf87
chromosome 11 open reading frame 87
chrX_+_38211735 2.070 NM_000531
OTC
ornithine carbamoyltransferase
chr19_-_17375522 2.064 NM_031941
USHBP1
Usher syndrome 1C binding protein 1
chr11_-_35441501 2.058 NM_001195728
NM_001252652
SLC1A2

solute carrier family 1 (glial high affinity glutamate transporter), member 2

chr2_-_135782246 2.050 NM_001018046
NM_025052
YSK4

YSK4 Sps1/Ste20-related kinase homolog (S. cerevisiae)

chr10_+_11207053 2.043 CELF2
CUGBP, Elav-like family member 2
chrX_-_50557019 2.034 NM_020717
SHROOM4
shroom family member 4
chr12_+_113495661 2.032 NM_004416
DTX1
deltex homolog 1 (Drosophila)
chr2_+_143886969 2.024 ARHGAP15
Rho GTPase activating protein 15
chr9_-_116840673 2.023 NM_001633
AMBP
alpha-1-microglobulin/bikunin precursor
chr9_-_95166827 2.019 NM_014057
NM_033014
OGN

osteoglycin

chr2_+_27070962 2.018 NM_020134
NM_001253723
NM_001253724
DPYSL5


dihydropyrimidinase-like 5


chr12_-_8815370 2.017 NM_003480
MFAP5
microfibrillar associated protein 5
chr14_-_73360792 2.016 NM_012074
DPF3
D4, zinc and double PHD fingers, family 3
chr20_+_17207596 2.008 NM_001201529
NM_002594
PCSK2

proprotein convertase subtilisin/kexin type 2

chr8_-_102803196 1.997 NCALD
neurocalcin delta
chr5_-_147286064 1.996 NM_206966
C5orf46
chromosome 5 open reading frame 46
chr9_+_115249357 1.981 KIAA1958
KIAA1958
chr14_-_88789531 1.976 NM_138317
KCNK10
potassium channel, subfamily K, member 10
chr2_-_107503056 1.964


chr17_-_39092714 1.950 KRT23
keratin 23 (histone deacetylase inducible)
chr2_-_174767282 1.940


chrX_-_15402469 1.934 NM_004469
FIGF
c-fos induced growth factor (vascular endothelial growth factor D)
chr15_-_50411405 1.933 NM_024837
ATP8B4
ATPase, class I, type 8B, member 4
chr8_-_70745624 1.927 NM_001146008
SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr10_-_98273444 1.926 NM_012465
TLL2
tolloid-like 2
chr8_-_93115453 1.918 NM_001198633
NM_175634
RUNX1T1

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

chr11_-_35441099 1.916 NM_004171
SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr19_-_51568323 1.911 NM_015596
KLK13
kallikrein-related peptidase 13
chr2_-_2334887 1.909 NM_015025
MYT1L
myelin transcription factor 1-like
chr5_+_147582338 1.905 NM_001195290
NM_205841
SPINK6

serine peptidase inhibitor, Kazal type 6

chr18_-_53177999 1.900 NM_001243231
TCF4
transcription factor 4
chr7_-_151107117 1.889 NM_198285
WDR86
WD repeat domain 86
chr20_+_17207669 1.888 PCSK2
proprotein convertase subtilisin/kexin type 2
chr12_-_6233684 1.887 NM_000552
VWF
von Willebrand factor
chr11_+_113775517 1.871 NM_006028
HTR3B
5-hydroxytryptamine (serotonin) receptor 3B
chr20_-_50179167 1.871 NM_001136021
NFATC2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
chr11_-_16497917 1.862 NM_033326
SOX6
SRY (sex determining region Y)-box 6
chr2_+_143886898 1.856 NM_018460
ARHGAP15
Rho GTPase activating protein 15
chr18_+_31158540 1.856 NM_030632
ASXL3
additional sex combs like 3 (Drosophila)
chr5_-_147162264 1.847 JAKMIP2
janus kinase and microtubule interacting protein 2
chr1_-_206288646 1.838 NM_001007544
C1orf186
chromosome 1 open reading frame 186
chr7_-_16505292 1.838 NM_015464
SOSTDC1
sclerostin domain containing 1
chr2_-_128421965 1.832 NM_017980
LIMS2
LIM and senescent cell antigen-like domains 2
chr1_+_9005921 1.831 NM_001215
CA6
carbonic anhydrase VI
chr7_+_80267922 1.822 CD36
CD36 molecule (thrombospondin receptor)
chr2_-_162931051 1.810 NM_001935
DPP4
dipeptidyl-peptidase 4
chr12_-_99548867 1.800 NM_001204067
ANKS1B
ankyrin repeat and sterile alpha motif domain containing 1B
chr7_-_84751246 1.797 NM_152754
SEMA3D
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
chr6_-_160679789 1.788 NM_003058
SLC22A2
solute carrier family 22 (organic cation transporter), member 2
chr20_-_21378046 1.787 NM_033176
NKX2-4
NK2 homeobox 4
chr19_-_47734215 1.783 NM_014417
BBC3
BCL2 binding component 3
chr7_-_14031049 1.780 NM_001163148
ETV1
ets variant 1
chr1_+_50571963 1.779 NM_001144775
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr3_+_115342302 1.779 GAP43
growth associated protein 43
chr9_-_73483933 1.779 NM_001007470
NM_020952
NM_024971
NM_206944
NM_206945
NM_206946
NM_206947
NM_206948
TRPM3







transient receptor potential cation channel, subfamily M, member 3







chr5_+_67588395 1.778 NM_001242466
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr11_+_131781303 1.776 NTM
neurotrimin
chr1_+_2938045 1.773 NM_080431
ACTRT2
actin-related protein T2
chr18_-_13915534 1.772 NM_000529
MC2R
melanocortin 2 receptor (adrenocorticotropic hormone)
chr5_-_87969135 1.768 LINC00461
long intergenic non-protein coding RNA 461
chr17_-_10452939 1.764 NM_001100112
NM_017534
MYH2

myosin, heavy chain 2, skeletal muscle, adult

chr8_+_85095501 1.757 NM_173848
RALYL
RALY RNA binding protein-like
chr9_-_140196702 1.751 NM_001004354
NRARP
NOTCH-regulated ankyrin repeat protein
chr4_-_174451356 1.748 NM_021973
HAND2
heart and neural crest derivatives expressed 2
chr4_-_20985547 1.746 KCNIP4
Kv channel interacting protein 4
chr3_+_181430075 1.736 SOX2
SRY (sex determining region Y)-box 2
chr3_+_134514300 1.735 EPHB1
EPH receptor B1
chr1_+_185703470 1.733 NM_031935
HMCN1
hemicentin 1
chr12_-_89746244 1.730 NM_001946
NM_022652
DUSP6

dual specificity phosphatase 6

chr5_+_170736287 1.728 NM_021025
TLX3
T-cell leukemia homeobox 3
chr7_+_123249076 1.725 NM_080928
ASB15
ankyrin repeat and SOCS box containing 15
chr20_+_30555804 1.724 NM_001011718
XKR7
XK, Kell blood group complex subunit-related family, member 7
chr7_-_117067514 1.724 NM_130768
ASZ1
ankyrin repeat, SAM and basic leucine zipper domain containing 1
chr5_-_148758787 1.721 NM_014443
IL17B
interleukin 17B
chr2_-_100722259 1.720 AFF3
AF4/FMR2 family, member 3
chr5_-_88119604 1.707 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr5_+_175308843 1.706 CPLX2
complexin 2
chr3_+_85775631 1.706 NM_153184
CADM2
cell adhesion molecule 2
chr4_-_101439071 1.705 NM_001159694
NM_016242
EMCN

endomucin

chr3_+_82035288 1.701


chr1_-_217250230 1.698 NM_001243507
NM_001243509
ESRRG

estrogen-related receptor gamma


Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.55 1.03e-06 GO:0032501 multicellular organismal process
1.40 5.46e-04 GO:0050896 response to stimulus
1.83 9.47e-04 GO:0030154 cell differentiation
1.78 2.50e-03 GO:0048869 cellular developmental process
1.51 8.94e-03 GO:0023052 signaling
1.50 9.18e-03 GO:0032502 developmental process
5.75 1.17e-02 GO:0045216 cell-cell junction organization
1.52 1.51e-02 GO:0007275 multicellular organismal development
1.90 2.23e-02 GO:0050877 neurological system process
1.78 2.61e-02 GO:0003008 system process
1.85 2.83e-02 GO:0007399 nervous system development

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
2.02 2.47e-07 GO:0005576 extracellular region
1.49 3.85e-04 GO:0071944 cell periphery
1.74 4.19e-04 GO:0044459 plasma membrane part
1.48 5.81e-04 GO:0005886 plasma membrane
2.02 5.47e-03 GO:0044421 extracellular region part
2.60 3.14e-02 GO:0009986 cell surface
3.32 3.44e-02 GO:0005911 cell-cell junction
2.21 4.22e-02 GO:0030054 cell junction

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
4.42 2.53e-03 GO:0008509 anion transmembrane transporter activity
1.78 5.40e-03 GO:0004872 receptor activity
1.66 1.05e-02 GO:0004871 signal transducer activity
1.66 1.05e-02 GO:0060089 molecular transducer activity
6.86 1.99e-02 GO:0003707 steroid hormone receptor activity
6.48 2.89e-02 GO:0004879 ligand-dependent nuclear receptor activity