Motif ID: SOX2.p2

Z-value: 1.232


Transcription factors associated with SOX2.p2:

Gene SymbolEntrez IDGene Name
SOX2 6657 SRY (sex determining region Y)-box 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SOX2hg19_v1_chr3_+_181429711_1814297150.431.0e-04Click!


Activity profile for motif SOX2.p2.

activity profile for motif SOX2.p2


Sorted Z-values histogram for motif SOX2.p2

Sorted Z-values for motif SOX2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_140474198 28.294 NM_018936
PCDHB2
protocadherin beta 2
chr15_+_25200069 27.070 NM_003097
NM_022804
NM_005678
SNRPN
SNURF

small nuclear ribonucleoprotein polypeptide N
SNRPN upstream reading frame

chr4_+_41258941 15.718 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr5_+_140254930 14.460 NM_018903
NM_031864
PCDHA12

protocadherin alpha 12

chrX_+_84499037 14.268 ZNF711
zinc finger protein 711
chr14_+_77228940 14.243 VASH1
vasohibin 1
chrX_-_64196268 12.361 NM_001178033
NM_018684
ZC4H2

zinc finger, C4H2 domain containing

chr5_+_140235594 11.983 NM_018901
NM_031859
NM_031860
PCDHA10


protocadherin alpha 10


chr5_+_140201221 11.848 NM_018908
NM_031501
PCDHA5

protocadherin alpha 5

chr12_-_28124915 11.288 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr17_-_16472463 11.255 NM_020653
ZNF287
zinc finger protein 287
chr3_+_186648515 10.701 ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr10_+_102732285 9.994 NM_001203244
NM_017893
SEMA4G

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G

chr5_-_150284293 9.943 ZNF300
zinc finger protein 300
chr3_+_186648273 9.742 NM_173216
NM_173217
ST6GAL1

ST6 beta-galactosamide alpha-2,6-sialyltranferase 1

chrX_+_84498993 9.437 NM_021998
ZNF711
zinc finger protein 711
chr5_-_150284503 9.285 NM_001172831
NM_001172832
NM_052860
ZNF300


zinc finger protein 300


chrX_-_38079980 9.024 NM_001170750
NM_001170751
NM_001170752
NM_006307
SRPX



sushi-repeat containing protein, X-linked



chr5_+_140480056 8.958 NM_018937
PCDHB3
protocadherin beta 3
chr4_+_41258909 8.939 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr12_-_8815266 8.879 MFAP5
microfibrillar associated protein 5
chr5_-_146435589 8.781 NM_181674
NM_181676
PPP2R2B

protein phosphatase 2, regulatory subunit B, beta

chr2_-_201967702 8.719


chr2_-_161056762 8.718 ITGB6
integrin, beta 6
chr4_-_186877413 8.711 SORBS2
sorbin and SH3 domain containing 2
chr4_-_186732047 8.706 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chrX_-_84634664 8.554 POF1B
premature ovarian failure, 1B
chr17_-_48072566 8.204 NM_005220
DLX3
distal-less homeobox 3
chrX_-_84634742 7.975 NM_024921
POF1B
premature ovarian failure, 1B
chr3_+_173116243 7.513 NM_014932
NLGN1
neuroligin 1
chr12_-_45307710 7.480 NM_001145110
NELL2
NEL-like 2 (chicken)
chr1_+_215256559 7.478 NM_001017425
NM_014217
KCNK2

potassium channel, subfamily K, member 2

chr1_+_100111430 7.404 NM_017734
PALMD
palmdelphin
chrX_-_84634396 7.378 POF1B
premature ovarian failure, 1B
chr17_-_39743085 7.146 NM_000526
KRT14
keratin 14
chr5_-_157002739 7.064 NM_033274
ADAM19
ADAM metallopeptidase domain 19
chr3_-_99594915 7.044 NM_014890
FILIP1L
filamin A interacting protein 1-like
chr12_-_8815370 6.959 NM_003480
MFAP5
microfibrillar associated protein 5
chr4_+_41258895 6.868 NM_004181
UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr2_-_86564632 6.815 NM_001164731
NM_001164732
NM_022912
REEP1


receptor accessory protein 1


chr7_+_28452143 6.744 NM_182898
CREB5
cAMP responsive element binding protein 5
chr4_-_186732208 6.707 NM_001145671
SORBS2
sorbin and SH3 domain containing 2
chr1_+_228337414 6.685 NM_020435
GJC2
gap junction protein, gamma 2, 47kDa
chr6_+_13925423 6.589 NM_001165033
RNF182
ring finger protein 182
chr12_-_8815479 6.560 MFAP5
microfibrillar associated protein 5
chr5_-_150284429 6.529 ZNF300
zinc finger protein 300
chr5_-_137475076 6.405 NM_003551
NME5
non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase)
chr5_-_150284390 6.384 ZNF300
zinc finger protein 300
chr7_-_83824216 6.304 NM_006080
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr9_+_4490193 6.239 NM_004170
SLC1A1
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
chr5_+_140593508 6.136 NM_018933
PCDHB13
protocadherin beta 13
chr15_-_45493372 6.025 NM_138356
SHF
Src homology 2 domain containing F
chr3_-_71353910 6.004 NM_001244812
FOXP1
forkhead box P1
chr5_+_140777603 5.854 NM_018925
NM_032099
PCDHGB5

protocadherin gamma subfamily B, 5

chr21_-_32931289 5.770 NM_003253
TIAM1
T-cell lymphoma invasion and metastasis 1
chr6_+_21666645 5.682 LINC00340
long intergenic non-protein coding RNA 340
chrX_-_47931000 5.538 NM_001190255
ZNF630
zinc finger protein 630
chr12_+_48876285 5.475 NM_152319
C12orf54
chromosome 12 open reading frame 54
chr2_+_217498082 5.417 NM_000597
IGFBP2
insulin-like growth factor binding protein 2, 36kDa
chr7_-_83270746 5.349 NM_001178129
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr7_-_111846384 5.318 NM_014705
DOCK4
dedicator of cytokinesis 4
chr17_+_74864427 5.116 NM_001199172
NM_144677
MGAT5B

mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B

chr17_-_46655544 5.107 NM_024015
HOXB4
homeobox B4
chr5_+_140207562 4.977 NM_018909
NM_031848
NM_031849
PCDHA6


protocadherin alpha 6


chr8_-_82395401 4.946 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr5_+_140213968 4.871 NM_018910
NM_031852
PCDHA7

protocadherin alpha 7

chr5_+_140602914 4.866 NM_018934
PCDHB14
protocadherin beta 14
chr19_+_7580987 4.856 NM_018083
ZNF358
zinc finger protein 358
chr3_-_99833348 4.805 NM_001042459
NM_182909
FILIP1L

filamin A interacting protein 1-like

chr5_+_140186658 4.764 NM_018907
NM_031500
PCDHA4

protocadherin alpha 4

chr1_+_45792544 4.734 NM_032756
HPDL
4-hydroxyphenylpyruvate dioxygenase-like
chr11_+_66790189 4.694 NM_001177880
SYT12
synaptotagmin XII
chr7_+_28725597 4.676 NM_001011666
CREB5
cAMP responsive element binding protein 5
chr1_+_87012758 4.642 NM_012128
CLCA4
chloride channel accessory 4
chr12_-_67072881 4.622 NM_001178074
NM_021150
GRIP1

glutamate receptor interacting protein 1

chr3_-_48601200 4.619 NM_033199
UCN2
urocortin 2
chr5_+_140560979 4.611 NM_020957
PCDHB16
protocadherin beta 16
chr1_-_95392501 4.601 NM_001839
CNN3
calponin 3, acidic
chr12_-_67072752 4.600 GRIP1
glutamate receptor interacting protein 1
chr14_-_21493122 4.586 NM_201538
NM_201539
NM_201540
NM_201541
NDRG2



NDRG family member 2



chr5_-_157002705 4.580


chr19_+_19976625 4.555 NM_021047
ZNF253
zinc finger protein 253
chr2_-_216246961 4.467 FN1
fibronectin 1
chr1_-_32801606 4.459 NM_023009
MARCKSL1
MARCKS-like 1
chr19_-_40324747 4.444 NM_004714
NM_006483
NM_006484
DYRK1B


dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B


chr5_-_146460991 4.388 NM_181677
NM_181678
PPP2R2B

protein phosphatase 2, regulatory subunit B, beta

chr17_+_67410825 4.378 NM_002758
MAP2K6
mitogen-activated protein kinase kinase 6
chr7_-_142583260 4.373 NM_018646
TRPV6
transient receptor potential cation channel, subfamily V, member 6
chr1_-_183387404 4.333


chr1_+_197886499 4.265 NM_020204
LHX9
LIM homeobox 9
chr19_-_18717577 4.210 CRLF1
cytokine receptor-like factor 1
chr12_-_45270071 4.152 NELL2
NEL-like 2 (chicken)
chr4_+_78078394 4.125 CCNG2
cyclin G2
chr19_-_18717631 4.124 NM_004750
CRLF1
cytokine receptor-like factor 1
chr8_+_79428335 4.113 NM_006823
NM_181839
PKIA

protein kinase (cAMP-dependent, catalytic) inhibitor alpha

chrX_-_48693934 4.108 NM_013271
PCSK1N
proprotein convertase subtilisin/kexin type 1 inhibitor
chr5_+_140557370 4.088 NM_019120
PCDHB8
protocadherin beta 8
chr2_+_37571752 4.026 NM_012413
QPCT
glutaminyl-peptide cyclotransferase
chr17_+_67498391 4.017 MAP2K6
mitogen-activated protein kinase kinase 6
chr12_-_28122884 3.969 NM_198964
NM_198966
PTHLH

parathyroid hormone-like hormone

chr5_-_111091947 3.916 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr1_-_183387501 3.840 NM_015039
NMNAT2
nicotinamide nucleotide adenylyltransferase 2
chr4_+_110749149 3.800 NM_006583
RRH
retinal pigment epithelium-derived rhodopsin homolog
chr5_+_140566655 3.798 NM_019119
PCDHB9
protocadherin beta 9
chr14_-_58618807 3.790 NM_001001872
C14orf37
chromosome 14 open reading frame 37
chr2_+_237478379 3.769 NM_020311
CXCR7
chemokine (C-X-C motif) receptor 7
chr1_+_90098643 3.768 NM_032270
LRRC8C
leucine rich repeat containing 8 family, member C
chr10_-_13749622 3.761 FRMD4A
FERM domain containing 4A
chr7_-_111846192 3.737 DOCK4
dedicator of cytokinesis 4
chr19_-_18717467 3.737 CRLF1
cytokine receptor-like factor 1
chr7_+_29519485 3.721 NM_001039936
CHN2
chimerin (chimaerin) 2
chr6_+_121756744 3.714 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr3_+_39509069 3.711 NM_182935
MOBP
myelin-associated oligodendrocyte basic protein
chr3_+_141105283 3.693


chr2_-_161056573 3.692 NM_000888
ITGB6
integrin, beta 6
chr4_+_78078332 3.680 NM_004354
CCNG2
cyclin G2
chr8_+_32504250 3.680 NM_013959
NRG1
neuregulin 1
chr3_-_123339178 3.676 MYLK
myosin light chain kinase
chr6_-_139613114 3.628 NM_153235
TXLNB
taxilin beta
chr3_-_123339423 3.621 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr5_-_64777703 3.618 NM_197941
ADAMTS6
ADAM metallopeptidase with thrombospondin type 1 motif, 6
chr7_-_14030864 3.592 NM_001163149
ETV1
ets variant 1
chrX_+_105937067 3.556 NM_024539
RNF128
ring finger protein 128
chr14_+_77228132 3.533 NM_014909
VASH1
vasohibin 1
chr19_+_20011700 3.516 NM_031218
ZNF93
zinc finger protein 93
chr2_+_149633173 3.507


chr15_-_50411405 3.503 NM_024837
ATP8B4
ATPase, class I, type 8B, member 4
chr1_+_92495484 3.501 NM_173567
EPHX4
epoxide hydrolase 4
chr14_-_92413738 3.498 FBLN5
fibulin 5
chr12_-_42877785 3.491 NM_001144882
NM_001144883
PRICKLE1

prickle homolog 1 (Drosophila)

chr3_+_19189969 3.464 NM_144633
KCNH8
potassium voltage-gated channel, subfamily H (eag-related), member 8
chr7_-_117513466 3.441 CTTNBP2
cortactin binding protein 2
chr3_+_181417387 3.428 SOX2-OT
SOX2 overlapping transcript (non-protein coding)
chr5_-_16936371 3.396 NM_012334
MYO10
myosin X
chr5_+_140165875 3.327 NM_018900
NM_031410
NM_031411
PCDHA1


protocadherin alpha 1


chr6_+_13924676 3.315 NM_001165034
RNF182
ring finger protein 182
chr20_-_56284945 3.296 NM_020182
PMEPA1
prostate transmembrane protein, androgen induced 1
chr9_-_77502635 3.291 NM_001177310
TRPM6
transient receptor potential cation channel, subfamily M, member 6
chr7_+_26400503 3.284 NM_001199837
SNX10
sorting nexin 10
chr5_-_111092865 3.256 C5orf13
chromosome 5 open reading frame 13
chr11_-_20181869 3.252 NM_001029865
DBX1
developing brain homeobox 1
chr19_-_17375522 3.250 NM_031941
USHBP1
Usher syndrome 1C binding protein 1
chr6_-_47253962 3.219 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr5_-_16936290 3.217 MYO10
myosin X
chr18_+_11751470 3.184 NM_001142339
NM_002071
GNAL

guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type

chr14_+_85996454 3.174 NM_013231
FLRT2
fibronectin leucine rich transmembrane protein 2
chr1_-_95392449 3.128 CNN3
calponin 3, acidic
chr12_-_111358353 3.125 NM_000432
MYL2
myosin, light chain 2, regulatory, cardiac, slow
chr9_-_21482311 3.125 NM_176891
IFNE
interferon, epsilon
chr17_-_39675078 3.114 NM_002275
KRT15
keratin 15
chr2_+_166428845 3.111 NM_024969
CSRNP3
cysteine-serine-rich nuclear protein 3
chr7_-_14031049 3.086 NM_001163148
ETV1
ets variant 1
chr1_+_90098693 3.081 LRRC8C
leucine rich repeat containing 8 family, member C
chr8_+_75736771 3.058 NM_015886
PI15
peptidase inhibitor 15
chr16_+_69141442 3.048 NM_005329
HAS3
hyaluronan synthase 3
chr10_+_11207053 3.035 CELF2
CUGBP, Elav-like family member 2
chr3_+_111260925 3.028 NM_005816
NM_198196
CD96

CD96 molecule

chr17_+_56065408 3.018


chr5_-_168271852 2.978


chr12_-_42877743 2.970 PRICKLE1
prickle homolog 1 (Drosophila)
chrX_-_128788913 2.943 NM_017413
APLN
apelin
chr10_-_23633771 2.938 NM_153714
C10orf67
chromosome 10 open reading frame 67
chr2_-_110873533 2.927 MALL
mal, T-cell differentiation protein-like
chr1_+_164528914 2.925 PBX1
pre-B-cell leukemia homeobox 1
chr14_+_85996512 2.921 FLRT2
fibronectin leucine rich transmembrane protein 2
chrX_+_107288199 2.919 NM_001170553
NM_182607
VSIG1

V-set and immunoglobulin domain containing 1

chr3_-_121740968 2.918 NM_001199799
NM_001199800
NM_175924
ILDR1


immunoglobulin-like domain containing receptor 1


chr3_-_149510609 2.915 NM_001144960
ANKUB1
ankyrin repeat and ubiquitin domain containing 1
chr13_+_53602829 2.907 NM_006418
OLFM4
olfactomedin 4
chr12_-_113909876 2.903 NM_022363
LHX5
LIM homeobox 5
chr2_-_110874142 2.900 NM_005434
MALL
mal, T-cell differentiation protein-like
chr5_-_111092918 2.891 NM_004772
C5orf13
chromosome 5 open reading frame 13
chr6_-_11779279 2.888 NM_001143948
NM_032744
C6orf105

chromosome 6 open reading frame 105

chr15_-_42186274 2.880 NM_016642
SPTBN5
spectrin, beta, non-erythrocytic 5
chr8_-_87755880 2.864 NM_019098
CNGB3
cyclic nucleotide gated channel beta 3
chr17_-_33759518 2.847 NM_018042
SLFN12
schlafen family member 12
chr1_+_203096835 2.833 NM_000674
NM_001048230
ADORA1

adenosine A1 receptor

chr11_-_85430117 2.833 NM_206929
SYTL2
synaptotagmin-like 2
chr9_+_2622134 2.831 VLDLR
very low density lipoprotein receptor
chr22_+_31090792 2.823 NM_030758
OSBP2
oxysterol binding protein 2
chr5_-_100238870 2.818 NM_175052
NM_005668
ST8SIA4

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4

chr1_+_90098624 2.809 LRRC8C
leucine rich repeat containing 8 family, member C
chr4_-_184243578 2.798 NM_001185149
CLDN24
claudin 24
chr2_-_208031570 2.784 KLF7
Kruppel-like factor 7 (ubiquitous)
chr11_+_130184326 2.776 FLJ34521
uncharacterized LOC646383
chr11_+_111808017 2.757 DIXDC1
DIX domain containing 1
chr11_+_57365026 2.750 NM_000062
SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr15_+_80696569 2.722 NM_014862
ARNT2
aryl-hydrocarbon receptor nuclear translocator 2
chr6_-_32163890 2.721 NOTCH4
notch 4
chr7_+_63773185 2.721 NM_001170905
ZNF736
zinc finger protein 736
chr5_+_140625146 2.713 NM_018935
PCDHB15
protocadherin beta 15
chr7_+_106505739 2.712 PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr4_+_76649739 2.696 USO1
USO1 vesicle docking protein homolog (yeast)
chr8_-_139926235 2.691 NM_152888
COL22A1
collagen, type XXII, alpha 1
chr7_+_89843133 2.674 NM_001040666
STEAP2
STEAP family member 2, metalloreductase
chr5_+_140588267 2.672 NM_018932
PCDHB12
protocadherin beta 12
chr9_+_2622099 2.669 VLDLR
very low density lipoprotein receptor
chr11_-_111782447 2.667 NM_001885
CRYAB
crystallin, alpha B
chr15_-_82338348 2.663 NM_032246
MEX3B
mex-3 homolog B (C. elegans)
chr5_-_39424930 2.660 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
8.85 3.52e-23 GO:0007156 homophilic cell adhesion
5.54 5.22e-21 GO:0016337 cell-cell adhesion
3.17 2.37e-15 GO:0007155 cell adhesion
3.17 2.37e-15 GO:0022610 biological adhesion
1.81 2.03e-14 GO:0007275 multicellular organismal development
1.85 3.98e-14 GO:0048856 anatomical structure development
1.74 8.05e-14 GO:0032502 developmental process
1.88 3.32e-13 GO:0048731 system development
2.31 9.76e-13 GO:0007399 nervous system development
1.54 1.12e-11 GO:0032501 multicellular organismal process
16.11 1.86e-10 GO:0016339 calcium-dependent cell-cell adhesion
10.22 6.46e-06 GO:0007416 synapse assembly
1.76 6.61e-06 GO:0030154 cell differentiation
1.71 2.94e-05 GO:0048869 cellular developmental process
2.21 1.77e-04 GO:0007267 cell-cell signaling
1.45 4.23e-04 GO:0023052 signaling
6.29 1.64e-03 GO:0050808 synapse organization
1.90 3.90e-03 GO:0007154 cell communication
1.94 4.52e-03 GO:0048468 cell development
9.46 8.49e-03 GO:0016338 calcium-independent cell-cell adhesion
2.39 9.49e-03 GO:0007268 synaptic transmission
2.04 1.49e-02 GO:0030182 neuron differentiation
2.26 1.60e-02 GO:0019226 transmission of nerve impulse
2.26 1.60e-02 GO:0035637 multicellular organismal signaling
2.12 2.64e-02 GO:0048666 neuron development
2.27 3.49e-02 GO:0048812 neuron projection morphogenesis
2.19 3.95e-02 GO:0031175 neuron projection development
2.17 4.94e-02 GO:0000904 cell morphogenesis involved in differentiation

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.50 5.98e-08 GO:0071944 cell periphery
1.50 9.82e-08 GO:0005886 plasma membrane
1.75 1.34e-07 GO:0044459 plasma membrane part
2.26 1.80e-04 GO:0030054 cell junction
3.19 8.44e-04 GO:0005911 cell-cell junction
1.23 9.10e-04 GO:0016020 membrane
1.54 2.16e-03 GO:0005576 extracellular region
1.72 2.79e-03 GO:0005887 integral to plasma membrane
1.69 5.11e-03 GO:0031226 intrinsic to plasma membrane
1.23 1.81e-02 GO:0044425 membrane part
1.26 1.91e-02 GO:0016021 integral to membrane
1.25 3.29e-02 GO:0031224 intrinsic to membrane

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
2.70 3.82e-09 GO:0005509 calcium ion binding
2.16 3.57e-02 GO:0015267 channel activity
2.16 3.73e-02 GO:0022803 passive transmembrane transporter activity