Motif ID: SMAD1..7,9.p2

Z-value: 1.688


Transcription factors associated with SMAD1..7,9.p2:

Gene SymbolEntrez IDGene Name
SMAD1 4086 SMAD family member 1
SMAD2 4087 SMAD family member 2
SMAD3 4088 SMAD family member 3
SMAD4 4089 SMAD family member 4
SMAD5 4090 SMAD family member 5
SMAD6 4091 SMAD family member 6
SMAD7 4092 SMAD family member 7
SMAD9 4093 SMAD family member 9

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SMAD9hg19_v1_chr13_-_37494370_374944080.513.4e-06Click!
SMAD1hg19_v1_chr4_+_146402704_1464030610.412.9e-04Click!
SMAD3hg19_v1_chr15_+_67358161_673581900.371.2e-03Click!
SMAD2hg19_v1_chr18_-_45456925_45456925-0.351.8e-03Click!
SMAD6hg19_v1_chr15_+_67000929_670009290.309.6e-03Click!
SMAD7hg19_v1_chr18_-_46476708_464768270.226.1e-02Click!
SMAD4hg19_v1_chr18_+_48556600_48556613-0.142.2e-01Click!
SMAD5hg19_v1_chr5_+_135468522_1354685370.122.9e-01Click!


Activity profile for motif SMAD1..7,9.p2.

activity profile for motif SMAD1..7,9.p2


Sorted Z-values histogram for motif SMAD1..7,9.p2

Sorted Z-values for motif SMAD1..7,9.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SMAD1..7,9.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_-_42448769 16.788 NM_213600
PLA2G4F
phospholipase A2, group IVF
chr8_-_143823823 9.867 NM_020427
SLURP1
secreted LY6/PLAUR domain containing 1
chr19_-_36019194 9.853 NM_001166034
NM_001166035
NM_198538
SBSN


suprabasin


chr8_-_143867931 7.517 NM_003695
LY6D
lymphocyte antigen 6 complex, locus D
chr19_-_41934634 6.609 NM_198540
B3GNT8
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8
chr16_-_79634610 6.453 NM_001031804
NM_005360
MAF

v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)

chr11_+_47608229 5.773 NM_001164379
FAM180B
family with sequence similarity 180, member B
chrX_-_48328601 5.455 NM_033518
SLC38A5
solute carrier family 38, member 5
chr12_-_53074172 5.167 NM_006121
KRT1
keratin 1
chr4_+_48485276 4.999 NM_152679
SLC10A4
solute carrier family 10 (sodium/bile acid cotransporter family), member 4
chr19_+_15783827 4.658 NM_023944
CYP4F12
cytochrome P450, family 4, subfamily F, polypeptide 12
chrX_-_48328564 4.637 SLC38A5
solute carrier family 38, member 5
chr19_-_51529869 4.322 NM_001136032
KLK11
kallikrein-related peptidase 11
chrX_-_13062720 4.251 NM_174901
FAM9C
family with sequence similarity 9, member C
chr9_+_35673852 4.248 NM_001216
CA9
carbonic anhydrase IX
chr19_+_2249112 4.033 NM_000479
AMH
anti-Mullerian hormone
chr11_-_60719116 4.033 NM_016582
SLC15A3
solute carrier family 15, member 3
chr7_+_54610018 3.996 NM_182546
VSTM2A
V-set and transmembrane domain containing 2A
chr10_-_102890902 3.985 NM_001085398
TLX1NB
TLX1 neighbor
chr19_-_51472816 3.985 NM_002774
KLK6
kallikrein-related peptidase 6
chrX_-_17879355 3.983 NM_001172732
NM_001172739
NM_001172743
NM_021785
RAI2



retinoic acid induced 2



chr11_-_2018885 3.780 H19
RPS12
H19, imprinted maternally expressed transcript (non-protein coding)
ribosomal protein S12
chr13_+_43136871 3.774 NM_033012
TNFSF11
tumor necrosis factor (ligand) superfamily, member 11
chr1_+_32827797 3.769 NM_052841
TSSK3
testis-specific serine kinase 3
chr6_+_47624222 3.755 NM_153839
GPR111
G protein-coupled receptor 111
chr2_+_17721806 3.744 NM_003385
VSNL1
visinin-like 1
chr20_+_30598244 3.712 NM_080625
C20orf160
chromosome 20 open reading frame 160
chr1_+_63789044 3.634 FOXD3
forkhead box D3
chr19_-_51456159 3.582 NM_001077491
NM_001077492
NM_012427
KLK5


kallikrein-related peptidase 5


chr2_+_17721983 3.571 VSNL1
visinin-like 1
chr15_+_77287738 3.525 PSTPIP1
proline-serine-threonine phosphatase interacting protein 1
chr9_+_92219926 3.496 NM_006705
GADD45G
growth arrest and DNA-damage-inducible, gamma
chr17_-_72588369 3.425 NM_001115152
CD300LD
CD300 molecule-like family member d
chr7_-_150652861 3.414 NM_001204798
NM_172057
KCNH2

potassium voltage-gated channel, subfamily H (eag-related), member 2

chrX_+_110339374 3.398 NM_002578
PAK3
p21 protein (Cdc42/Rac)-activated kinase 3
chr11_-_2019007 3.379 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr1_+_201159952 3.328 NM_001164586
IGFN1
immunoglobulin-like and fibronectin type III domain containing 1
chr11_+_60869929 3.295 NM_014207
CD5
CD5 molecule
chr22_+_24891114 3.286 NM_016327
UPB1
ureidopropionase, beta
chr2_+_176969233 3.285


chr9_-_97401746 3.214 FBP1
fructose-1,6-bisphosphatase 1
chr1_-_166135951 3.200 NM_001017961
FAM78B
family with sequence similarity 78, member B
chr22_-_42310670 3.181 NM_001207020
SHISA8
shisa homolog 8 (Xenopus laevis)
chr7_+_148036528 3.167 CNTNAP2
contactin associated protein-like 2
chr18_-_61311465 3.156 NM_002974
SERPINB4
serpin peptidase inhibitor, clade B (ovalbumin), member 4
chr9_+_17578952 3.154 NM_003026
SH3GL2
SH3-domain GRB2-like 2
chr1_-_166136076 3.139 FAM78B
family with sequence similarity 78, member B
chr15_+_77287428 3.133 NM_003978
PSTPIP1
proline-serine-threonine phosphatase interacting protein 1
chr1_+_26644458 3.130 CD52
CD52 molecule
chr1_+_63788729 3.125 NM_012183
FOXD3
forkhead box D3
chr17_-_50235976 3.093 CA10
carbonic anhydrase X
chr4_+_55523906 3.092 NM_000222
NM_001093772
KIT

v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

chr17_-_19619878 3.069 NM_001099646
NM_152908
SLC47A2

solute carrier family 47, member 2

chr11_-_2017822 3.039 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr17_-_50236124 3.035 NM_020178
CA10
carbonic anhydrase X
chr9_-_97402530 2.967 NM_001127628
FBP1
fructose-1,6-bisphosphatase 1
chr5_+_113698015 2.967 NM_021614
KCNN2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr8_-_70747200 2.963 NM_030958
SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr17_+_180995 2.962 NM_001242780
LOC100506388
uncharacterized LOC100506388
chr7_-_150675236 2.911 NM_000238
NM_172056
KCNH2

potassium voltage-gated channel, subfamily H (eag-related), member 2

chr17_-_9929567 2.910 NM_001130831
GAS7
growth arrest-specific 7
chr22_-_29711650 2.879 NM_001007279
NM_006477
RASL10A

RAS-like, family 10, member A

chr6_+_118228688 2.861 NM_001029858
SLC35F1
solute carrier family 35, member F1
chr8_+_106331146 2.830 NM_012082
ZFPM2
zinc finger protein, multitype 2
chr2_-_102003859 2.830 CREG2
cellular repressor of E1A-stimulated genes 2
chr2_+_169926084 2.828 DHRS9
dehydrogenase/reductase (SDR family) member 9
chr9_-_97401833 2.823 NM_000507
FBP1
fructose-1,6-bisphosphatase 1
chr20_+_10199455 2.810 NM_003081
NM_130811
SNAP25

synaptosomal-associated protein, 25kDa

chr19_+_12175513 2.809 NM_001136501
ZNF844
zinc finger protein 844
chr2_+_149632836 2.805 KIF5C
kinesin family member 5C
chr1_+_4715104 2.802 NM_001042478
NM_018836
AJAP1

adherens junctions associated protein 1

chr11_-_34535302 2.792 NM_001243080
NM_001422
ELF5

E74-like factor 5 (ets domain transcription factor)

chr3_-_50349811 2.763 NM_153281
HYAL1
hyaluronoglucosaminidase 1
chr6_+_30951484 2.756 NM_001010909
MUC21
mucin 21, cell surface associated
chr2_-_237076613 2.749 NM_001485
GBX2
gastrulation brain homeobox 2
chr14_-_106092256 2.733 IGHG4
immunoglobulin heavy constant gamma 4 (G4m marker)
chr17_+_42385780 2.726 NM_001144825
NM_001144826
NM_006695
RUNDC3A


RUN domain containing 3A


chr11_-_66103874 2.720 NM_004292
RIN1
Ras and Rab interactor 1
chr3_+_44626453 2.719 NM_173658
ZNF660
zinc finger protein 660
chr12_-_123214882 2.716 NM_032554
HCAR1
hydroxycarboxylic acid receptor 1
chr11_+_74870824 2.713 NM_001145211
SLCO2B1
solute carrier organic anion transporter family, member 2B1
chr5_+_113698304 2.710 KCNN2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr5_+_40909558 2.710 NM_000587
C7
complement component 7
chr14_-_94984180 2.701 NM_173850
SERPINA12
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
chr5_+_40909617 2.690 C7
complement component 7
chr17_+_7741630 2.685


chr1_-_198906536 2.671 LOC100131234
familial acute myelogenous leukemia related factor
chr19_-_12945376 2.660 RTBDN
retbindin
chr15_+_33603162 2.659 NM_001036
NM_001243996
RYR3

ryanodine receptor 3

chr9_-_140063854 2.659


chr1_-_32827843 2.655 NM_001167676
LOC100128071
uncharacterized LOC100128071
chr1_-_166135978 2.654


chr20_-_43936919 2.650 NM_003833
NM_030590
NM_030592
MATN4


matrilin 4


chr5_-_138842291 2.642 NM_001077693
ECSCR
endothelial cell-specific chemotaxis regulator
chr7_-_82792127 2.632 NM_014510
NM_033026
PCLO

piccolo (presynaptic cytomatrix protein)

chr4_+_72052354 2.621 NM_001098484
NM_001134742
SLC4A4

solute carrier family 4, sodium bicarbonate cotransporter, member 4

chr3_+_139654206 2.619 CLSTN2
calsyntenin 2
chr22_-_46449972 2.619 NM_018280
C22orf26
chromosome 22 open reading frame 26
chr3_+_89156804 2.604 EPHA3
EPH receptor A3
chr11_-_2018568 2.600 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr21_+_46057272 2.587 NM_181688
KRTAP10-10
keratin associated protein 10-10
chr9_-_97402556 2.576 FBP1
fructose-1,6-bisphosphatase 1
chr12_-_51717941 2.565 BIN2
bridging integrator 2
chr7_-_44228880 2.562 NM_000162
GCK
glucokinase (hexokinase 4)
chr6_+_135502445 2.561 NM_001130172
NM_001130173
NM_001161656
NM_001161657
NM_001161658
NM_001161659
NM_001161660
NM_005375
MYB







v-myb myeloblastosis viral oncogene homolog (avian)







chr12_-_51717835 2.557 BIN2
bridging integrator 2
chr18_-_45935627 2.550 ZBTB7C
zinc finger and BTB domain containing 7C
chr12_-_51717905 2.538 NM_016293
BIN2
bridging integrator 2
chrX_-_50557019 2.528 NM_020717
SHROOM4
shroom family member 4
chr15_-_40398573 2.527 NM_033503
BMF
Bcl2 modifying factor
chr10_-_82116499 2.517 NM_138812
DYDC1
DPY30 domain containing 1
chr1_-_112531669 2.493 NM_004980
NM_172198
KCND3

potassium voltage-gated channel, Shal-related subfamily, member 3

chr1_-_220101925 2.460 NM_018713
SLC30A10
solute carrier family 30, member 10
chr17_+_79860071 2.443 NM_148896
NPB
neuropeptide B
chr4_+_190995385 2.441 NM_012147
NM_001127388
NM_001127389
NM_001164467
NM_001127386
DUX2
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 2
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr3_-_39322763 2.436 NM_001171171
CX3CR1
chemokine (C-X3-C motif) receptor 1
chr9_-_94712079 2.430 NM_004560
ROR2
receptor tyrosine kinase-like orphan receptor 2
chr12_+_50355278 2.418 NM_001651
AQP5
aquaporin 5
chr18_-_4455247 2.412 DLGAP1
discs, large (Drosophila) homolog-associated protein 1
chr10_-_5541401 2.412 NM_017422
CALML5
calmodulin-like 5
chr2_+_233404436 2.408 NM_005199
CHRNG
cholinergic receptor, nicotinic, gamma
chr14_-_88793250 2.407 NM_021161
KCNK10
potassium channel, subfamily K, member 10
chr19_+_35773409 2.405 NM_021175
HAMP
hepcidin antimicrobial peptide
chr19_-_51472003 2.399 NM_001012964
NM_001012965
KLK6

kallikrein-related peptidase 6

chr11_-_2018703 2.389 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr18_-_4455265 2.366 NM_001242761
NM_004746
DLGAP1

discs, large (Drosophila) homolog-associated protein 1

chr7_-_82791799 2.364 PCLO
piccolo (presynaptic cytomatrix protein)
chr10_+_135480367 2.360 NM_033178
NM_012147
NM_001127387
NM_001127388
NM_001127389
NM_001164467
NM_001127386
DUX4
DUX2
DUX4L7
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 7
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr12_+_47473367 2.350 FAM113B
family with sequence similarity 113, member B
chr19_+_827821 2.347 NM_001700
AZU1
azurocidin 1
chr6_+_135502521 2.340 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr11_-_111383063 2.339 NM_017589
BTG4
B-cell translocation gene 4
chr14_+_105391154 2.335 PLD4
phospholipase D family, member 4
chr6_+_133562488 2.332 NM_004100
NM_172103
NM_172105
EYA4


eyes absent homolog 4 (Drosophila)


chr9_+_139871954 2.331 NM_000954
PTGDS
prostaglandin D2 synthase 21kDa (brain)
chr1_+_179712297 2.329 NM_173509
FAM163A
family with sequence similarity 163, member A
chr1_-_109825683 2.323 PSRC1
proline/serine-rich coiled-coil 1
chr17_-_34079896 2.322 NM_139285
GAS2L2
growth arrest-specific 2 like 2
chr12_-_122658723 2.316 NM_001014336
IL31
interleukin 31
chr1_-_226128872 2.314 NM_001172425
NM_003240
LEFTY2

left-right determination factor 2

chr7_-_141646716 2.313 NM_013252
CLEC5A
C-type lectin domain family 5, member A
chr14_+_105391165 2.313 NM_138790
PLD4
phospholipase D family, member 4
chr4_+_191005266 2.313 NM_033178
NM_012147
NM_001177376
NM_001127388
NM_001127389
NM_001164467
NM_001127386
DUX4
DUX2
DUX4L4
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 4
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr4_+_191011859 2.313 NM_033178
NM_012147
NM_001177376
NM_001127388
NM_001127389
NM_001164467
NM_001127386
DUX4
DUX2
DUX4L4
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 4
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr17_-_7017971 2.308 ASGR2
asialoglycoprotein receptor 2
chr9_-_21975131 2.304 NM_000077
NM_001195132
CDKN2A

cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)

chr4_+_190998678 2.300 NM_012147
NM_001127388
NM_001127389
NM_001164467
NM_001127386
DUX2
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 2
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr19_-_45663407 2.276 NM_198478
NKPD1
NTPase, KAP family P-loop domain containing 1
chr17_-_45056588 2.272 NM_203400
RPRML
reprimo-like
chr11_+_118215058 2.272 NM_000073
CD3G
CD3g molecule, gamma (CD3-TCR complex)
chr1_+_26644380 2.272 NM_001803
CD52
CD52 molecule
chr14_+_105391150 2.268 PLD4
phospholipase D family, member 4
chr6_+_70576447 2.261 NM_001858
COL19A1
collagen, type XIX, alpha 1
chr11_+_113845796 2.257 NM_000869
NM_213621
HTR3A

5-hydroxytryptamine (serotonin) receptor 3A

chr1_+_55464605 2.256 NM_057176
BSND
Bartter syndrome, infantile, with sensorineural deafness (Barttin)
chr6_+_110300197 2.243 NM_005284
GPR6
G protein-coupled receptor 6
chr13_-_97646603 2.237 NM_080818
OXGR1
oxoglutarate (alpha-ketoglutarate) receptor 1
chr10_+_135490278 2.233 NM_001127388
NM_001127389
NM_001164467
NM_001127386
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr5_-_149535309 2.233 PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr11_-_18813127 2.229 NM_001039970
NM_006906
NM_032781
PTPN5


protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)


chr4_+_118954763 2.228 NDST3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr19_-_14049167 2.227 NM_024825
PODNL1
podocan-like 1
chr1_+_110009220 2.221 SYPL2
synaptophysin-like 2
chr10_+_135493659 2.220 NM_012147
DUX2
double homeobox 2
chr4_+_190988866 2.205 NM_012147
DUX2
double homeobox 2
chr14_+_105391215 2.202 PLD4
phospholipase D family, member 4
chr2_-_102003923 2.197 NM_153836
CREG2
cellular repressor of E1A-stimulated genes 2
chr8_-_143858436 2.190 NM_177476
NM_177477
LYNX1

Ly6/neurotoxin 1

chr4_+_15779887 2.184 NM_001775
CD38
CD38 molecule
chr4_+_191001978 2.184 NM_001177376
DUX4L4
double homeobox 4 like 4
chr17_+_37784750 2.181 NM_001242464
NM_181505
PPP1R1B

protein phosphatase 1, regulatory (inhibitor) subunit 1B

chr9_-_21974825 2.178 NM_058197
CDKN2A
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
chr9_-_140335790 2.178 NM_001033113
NM_198585
ENTPD8

ectonucleoside triphosphate diphosphohydrolase 8

chr1_+_16062808 2.166 NM_207348
SLC25A34
solute carrier family 25, member 34
chr1_+_159141376 2.165 NM_021189
NM_001127173
CADM3

cell adhesion molecule 3

chr19_-_47975244 2.164 NM_015063
SLC8A2
solute carrier family 8 (sodium/calcium exchanger), member 2
chr1_+_205012427 2.155 CNTN2
contactin 2 (axonal)
chr12_-_9360960 2.152 NM_002864
PZP
pregnancy-zone protein
chr19_-_55668956 2.149 NM_000363
TNNI3
troponin I type 3 (cardiac)
chr12_+_2162703 2.149 CACNA1C
calcium channel, voltage-dependent, L type, alpha 1C subunit
chr3_+_9944295 2.147 NM_153483
IL17RE
interleukin 17 receptor E
chr22_+_24823529 2.147 NM_000675
ADORA2A
adenosine A2a receptor
chrX_+_153170528 2.143 NM_000054
NM_001146151
AVPR2

arginine vasopressin receptor 2

chr16_-_55909208 2.141 NM_001143685
NM_145024
CES5A

carboxylesterase 5A

chr11_-_101000457 2.140 NM_000926
PGR
progesterone receptor
chr4_+_191008565 2.133 NM_012147
NM_001127388
NM_001127389
NM_001164467
NM_001127386
DUX2
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 2
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr8_+_143545376 2.132 NM_001702
BAI1
brain-specific angiogenesis inhibitor 1
chr2_+_209224568 2.127 PTH2R
parathyroid hormone 2 receptor
chr1_+_110009099 2.124 NM_001040709
SYPL2
synaptophysin-like 2
chr11_-_2019070 2.122 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr2_+_128293312 2.120 NM_001080527
MYO7B
myosin VIIB
chr7_-_102283237 2.108 NM_001114403
UPK3BL
uroplakin 3B-like
chr16_+_88705000 2.105 NM_013278
IL17C
interleukin 17C
chr15_+_77287688 2.100 PSTPIP1
proline-serine-threonine phosphatase interacting protein 1
chr12_+_56623819 2.099 NM_173596
SLC39A5
solute carrier family 39 (metal ion transporter), member 5
chr3_+_134514300 2.096 EPHB1
EPH receptor B1
chr1_-_108507474 2.086 NM_006113
VAV3
vav 3 guanine nucleotide exchange factor
chr7_+_73442426 2.085 NM_000501
NM_001081752
NM_001081753
NM_001081754
NM_001081755
ELN




elastin




chr19_-_11689591 2.083 NM_001111034
ACP5
acid phosphatase 5, tartrate resistant
chr21_+_15588465 2.079 NM_144770
RBM11
RNA binding motif protein 11

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.67 3.71e-07 GO:0048731 system development
1.57 1.34e-06 GO:0007275 multicellular organismal development
1.60 1.99e-06 GO:0048856 anatomical structure development
1.50 2.27e-05 GO:0032502 developmental process
1.66 3.86e-04 GO:0030154 cell differentiation
1.87 4.31e-04 GO:0051239 regulation of multicellular organismal process
1.79 5.80e-04 GO:0007399 nervous system development
1.35 5.87e-04 GO:0032501 multicellular organismal process
1.63 7.63e-04 GO:0048869 cellular developmental process
1.66 1.61e-03 GO:0048513 organ development
2.32 2.53e-03 GO:0007186 G-protein coupled receptor protein signaling pathway
2.01 3.31e-03 GO:0048699 generation of neurons
1.97 3.79e-03 GO:0022008 neurogenesis
1.95 4.87e-03 GO:0048468 cell development
1.40 7.51e-03 GO:0023052 signaling
2.09 8.33e-03 GO:0030182 neuron differentiation
1.93 9.39e-03 GO:0006811 ion transport
4.26 1.77e-02 GO:0006816 calcium ion transport
3.57 3.38e-02 GO:0070838 divalent metal ion transport
2.11 3.74e-02 GO:0048666 neuron development
2.18 4.39e-02 GO:0007417 central nervous system development
3.46 4.89e-02 GO:0072511 divalent inorganic cation transport
1.56 4.99e-02 GO:0007166 cell surface receptor linked signaling pathway

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.52 1.88e-08 GO:0071944 cell periphery
1.52 3.22e-08 GO:0005886 plasma membrane
1.76 6.35e-07 GO:0005576 extracellular region
1.87 6.89e-05 GO:0005887 integral to plasma membrane
1.83 1.39e-04 GO:0031226 intrinsic to plasma membrane
1.57 4.56e-04 GO:0044459 plasma membrane part
2.75 8.72e-04 GO:0044456 synapse part
2.43 1.34e-03 GO:0045202 synapse
3.29 7.48e-03 GO:0045211 postsynaptic membrane
1.24 3.69e-02 GO:0031224 intrinsic to membrane
1.24 4.50e-02 GO:0016021 integral to membrane
2.63 4.59e-02 GO:0034702 ion channel complex

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
2.27 4.41e-05 GO:0043565 sequence-specific DNA binding
1.72 1.20e-04 GO:0004872 receptor activity
1.82 2.55e-04 GO:0004888 transmembrane receptor activity
1.58 1.04e-03 GO:0004871 signal transducer activity
1.58 1.04e-03 GO:0060089 molecular transducer activity
1.87 1.74e-03 GO:0001071 nucleic acid binding transcription factor activity
1.87 1.74e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
1.94 7.26e-03 GO:0015075 ion transmembrane transporter activity
2.53 8.80e-03 GO:0022836 gated channel activity
1.85 9.22e-03 GO:0022891 substrate-specific transmembrane transporter activity
1.78 1.68e-02 GO:0022857 transmembrane transporter activity
2.21 2.50e-02 GO:0022803 passive transmembrane transporter activity
2.20 3.44e-02 GO:0022838 substrate-specific channel activity
1.99 3.84e-02 GO:0008324 cation transmembrane transporter activity
1.64 4.31e-02 GO:0005215 transporter activity