Motif ID: RXRG_dimer.p3

Z-value: 0.752


Transcription factors associated with RXRG_dimer.p3:

Gene SymbolEntrez IDGene Name
NR1H2 7376 nuclear receptor subfamily 1, group H, member 2
PPARA 5465 peroxisome proliferator-activated receptor alpha
PPARG 5468 peroxisome proliferator-activated receptor gamma
RXRA 6256 retinoid X receptor, alpha
RXRB 6257 retinoid X receptor, beta
RXRG 6258 retinoid X receptor, gamma

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
RXRBhg19_v1_chr6_-_33168163_33168253-0.361.7e-03Click!
RXRGhg19_v1_chr1_-_165414499_165414591-0.325.1e-03Click!
PPARAhg19_v1_chr22_+_46546498_465465620.243.8e-02Click!
PPARGhg19_v1_chr3_+_12329332_123295810.113.6e-01Click!
NR1H2hg19_v1_chr19_+_50879681_508797730.103.9e-01Click!
RXRAhg19_v1_chr9_+_137218313_1372183180.075.4e-01Click!


Activity profile for motif RXRG_dimer.p3.

activity profile for motif RXRG_dimer.p3


Sorted Z-values histogram for motif RXRG_dimer.p3

Sorted Z-values for motif RXRG_dimer.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of RXRG_dimer.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_45116921 7.285 NM_001205280
IGSF23
immunoglobulin superfamily, member 23
chr19_-_55580896 5.521 NM_138412
RDH13
retinol dehydrogenase 13 (all-trans/9-cis)
chr1_-_29309092 3.897


chr5_+_92918924 3.223 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr5_-_42811959 2.950 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr1_+_78354199 2.779 NM_001172309
NM_144573
NEXN

nexilin (F actin binding protein)

chr1_-_155881063 2.628 RIT1
Ras-like without CAAX 1
chr7_+_97841565 2.564 NM_177455
BHLHA15
basic helix-loop-helix family, member a15
chr19_+_54606141 2.555 NM_004542
NDUFA3
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
chr4_+_30721865 2.285 NM_032456
NM_001173523
NM_002589
NM_032457
PCDH7



protocadherin 7



chr1_-_155881163 2.217 NM_006912
RIT1
Ras-like without CAAX 1
chr3_-_48936227 2.086 NM_000387
SLC25A20
solute carrier family 25 (carnitine/acylcarnitine translocase), member 20
chr19_+_44100734 2.017 NM_001145347
ZNF576
zinc finger protein 576
chr4_+_30722191 1.956 PCDH7
protocadherin 7
chr19_-_45579687 1.893 NM_145288
ZNF296
zinc finger protein 296
chr1_-_151138330 1.819 NM_212551
NM_001136543
LYSMD1

LysM, putative peptidoglycan-binding, domain containing 1

chr12_-_118810550 1.776 TAOK3
TAO kinase 3
chr11_-_116708334 1.750 NM_000039
APOA1
apolipoprotein A-I
chr22_-_24059524 1.668 GUSBP11
glucuronidase, beta pseudogene 11
chr1_+_61547625 1.645 NM_001134673
NM_005595
NFIA

nuclear factor I/A

chr19_+_45394642 1.629 TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr11_+_118868861 1.627 CCDC84
coiled-coil domain containing 84
chr11_+_118868841 1.573 NM_198489
CCDC84
coiled-coil domain containing 84
chr22_-_24059502 1.572 GUSBP11
glucuronidase, beta pseudogene 11
chr19_+_45394522 1.565 TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr12_-_118810712 1.546 NM_016281
TAOK3
TAO kinase 3
chr11_-_61658853 1.506 NM_021727
FADS3
fatty acid desaturase 3
chr19_+_39616384 1.456 NM_001014831
NM_001014832
NM_001014834
NM_001014835
NM_005884
PAK4




p21 protein (Cdc42/Rac)-activated kinase 4




chr17_+_7812703 1.429 CHD3
chromodomain helicase DNA binding protein 3
chr9_+_88897112 1.427


chr3_-_113464640 1.425 NAA50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr19_+_6372720 1.424 ALKBH7
alkB, alkylation repair homolog 7 (E. coli)
chr7_+_143079354 1.407 ZYX
zyxin
chr11_+_116700620 1.406 NM_000040
APOC3
apolipoprotein C-III
chr7_-_139763520 1.394 NM_022750
PARP12
poly (ADP-ribose) polymerase family, member 12
chr19_+_6372443 1.370 NM_032306
ALKBH7
alkB, alkylation repair homolog 7 (E. coli)
chr19_-_38806381 1.370 NM_001039671
NM_001145461
NM_001145462
YIF1B


Yip1 interacting factor homolog B (S. cerevisiae)


chr1_-_43855473 1.342 NM_052877
NM_201542
MED8

mediator complex subunit 8

chr19_+_39390567 1.337 NM_002503
NFKBIB
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr2_-_64246431 1.325 VPS54
vacuolar protein sorting 54 homolog (S. cerevisiae)
chr19_+_6372805 1.311 ALKBH7
alkB, alkylation repair homolog 7 (E. coli)
chr1_-_43855448 1.307 MED8
mediator complex subunit 8
chr6_+_143999058 1.265 NM_001100164
NM_001100165
PHACTR2

phosphatase and actin regulator 2

chr22_-_24059436 1.252


chr12_+_96252705 1.242 NM_003095
SNRPF
small nuclear ribonucleoprotein polypeptide F
chr7_+_143079925 1.213 ZYX
zyxin
chr18_+_54318561 1.207 NM_015285
NM_052834
WDR7

WD repeat domain 7

chr1_+_12079552 1.204 MIIP
migration and invasion inhibitory protein
chr22_-_41864656 1.177 NM_032758
PHF5A
PHD finger protein 5A
chr13_+_100741268 1.158 NM_000282
NM_001127692
NM_001178004
PCCA


propionyl CoA carboxylase, alpha polypeptide


chr2_-_176046120 1.149 NM_001002258
NM_001190329
NM_001689
ATP5G3


ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)


chr2_+_178257371 1.133 NM_003659
AGPS
alkylglycerone phosphate synthase
chr19_+_10362912 1.127 MRPL4
mitochondrial ribosomal protein L4
chr17_-_8198605 1.114 SLC25A35
solute carrier family 25, member 35
chr2_+_178257488 1.111 AGPS
alkylglycerone phosphate synthase
chr19_+_39390618 1.092 NFKBIB
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr2_-_28113211 1.076 NM_022128
RBKS
ribokinase
chr6_+_143771779 1.060 NM_003630
PEX3
peroxisomal biogenesis factor 3
chr7_+_129015483 1.059 NM_001130722
AHCYL2
adenosylhomocysteinase-like 2
chr11_-_45939361 1.051 PEX16
peroxisomal biogenesis factor 16
chr12_+_96252770 1.018 SNRPF
small nuclear ribonucleoprotein polypeptide F
chr2_-_24307179 0.998 NM_001206802
TP53I3
tumor protein p53 inducible protein 3
chr19_+_10362886 0.992 MRPL4
mitochondrial ribosomal protein L4
chrX_-_122866881 0.976 THOC2
THO complex 2
chr3_-_113465101 0.963 NM_025146
NAA50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr21_+_45432202 0.953 NM_003274
TRAPPC10
trafficking protein particle complex 10
chrX_-_122866888 0.933 NM_001081550
THOC2
THO complex 2
chr1_+_12079522 0.928 MIIP
migration and invasion inhibitory protein
chr6_-_146285225 0.922 NM_001042683
NM_173082
SHPRH

SNF2 histone linker PHD RING helicase

chr1_-_120484230 0.894 NOTCH2
notch 2
chr17_-_8198124 0.888 NM_201520
SLC25A35
solute carrier family 25, member 35
chr16_-_30596808 0.885 NM_152458
ZNF785
zinc finger protein 785
chr4_-_7069755 0.881 NM_025196
GRPEL1
GrpE-like 1, mitochondrial (E. coli)
chr8_+_22423170 0.876 NM_001018003
SORBS3
sorbin and SH3 domain containing 3
chr14_-_95623606 0.874 DICER1
dicer 1, ribonuclease type III
chr2_+_120125141 0.872 NM_001079863
DBI
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
chr20_-_32899607 0.869 NM_001161766
AHCY
adenosylhomocysteinase
chr4_-_4543690 0.869 STX18
syntaxin 18
chr19_+_39390570 0.858 NFKBIB
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr19_+_2328628 0.846 NM_001077238
NM_152988
SPPL2B

signal peptide peptidase-like 2B

chr16_-_47007567 0.837 NM_005880
DNAJA2
DnaJ (Hsp40) homolog, subfamily A, member 2
chr15_+_96873845 0.836 NM_021005
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr11_-_45939568 0.797 NM_004813
NM_057174
PEX16

peroxisomal biogenesis factor 16

chr19_+_16308664 0.796 NM_001130524
NM_032493
AP1M1

adaptor-related protein complex 1, mu 1 subunit

chr5_+_1801493 0.789 NM_004553
NDUFS6
NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)
chr16_-_4401265 0.783 NM_016069
PAM16
presequence translocase-associated motor 16 homolog (S. cerevisiae)
chr17_+_41150465 0.780 RPL27
ribosomal protein L27
chr2_+_73441344 0.775 NM_006062
SMYD5
SMYD family member 5
chr2_-_207024103 0.768 NM_001199981
NM_001199982
NM_001199983
NM_005006
NDUFS1



NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)



chr20_+_36662138 0.767 RPRD1B
regulation of nuclear pre-mRNA domain containing 1B
chr17_+_41150409 0.764 NM_000988
RPL27
ribosomal protein L27
chr15_+_43885251 0.763 NM_020990
CKMT1B
CKMT1A
creatine kinase, mitochondrial 1B
creatine kinase, mitochondrial 1A
chr4_-_4543719 0.755 STX18
syntaxin 18
chr20_+_36662207 0.753


chr3_-_113464991 0.725 NAA50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr12_-_51422012 0.724 NM_001174125
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr22_+_30163351 0.721 NM_001003684
NM_013387
UQCR10

ubiquinol-cytochrome c reductase, complex III subunit X

chr16_-_47007483 0.720 DNAJA2
DnaJ (Hsp40) homolog, subfamily A, member 2
chr7_-_74489636 0.716 WBSCR16
Williams-Beuren syndrome chromosome region 16
chr19_-_38806546 0.707 NM_001039672
NM_001039673
NM_001145463
YIF1B


Yip1 interacting factor homolog B (S. cerevisiae)


chr10_-_96829074 0.706 NM_000770
NM_001198853
NM_001198854
NM_001198855
CYP2C8



cytochrome P450, family 2, subfamily C, polypeptide 8



chr2_+_220299699 0.690 NM_005876
SPEG
SPEG complex locus
chr20_-_44485953 0.685 NM_005469
ACOT8
acyl-CoA thioesterase 8
chr8_-_80942488 0.670 NM_014018
MRPS28
mitochondrial ribosomal protein S28
chr16_+_4714709 0.666 MGRN1
mahogunin, ring finger 1
chr19_+_45394459 0.655 NM_001128916
NM_001128917
NM_006114
TOMM40


translocase of outer mitochondrial membrane 40 homolog (yeast)


chr7_-_72936447 0.653 BAZ1B
bromodomain adjacent to zinc finger domain, 1B
chr1_-_101491308 0.643 NM_001077394
NM_001077395
NM_015958
DPH5


DPH5 homolog (S. cerevisiae)


chr14_-_95623665 0.629 NM_177438
DICER1
dicer 1, ribonuclease type III
chr3_-_194392913 0.617 LSG1
large subunit GTPase 1 homolog (S. cerevisiae)
chrX_-_108868250 0.616 NM_012282
KCNE1L
KCNE1-like
chr1_+_151138497 0.601 NM_001204856
NM_024041
SCNM1

sodium channel modifier 1

chr6_-_146285170 0.593 SHPRH
SNF2 histone linker PHD RING helicase
chr12_-_95467104 0.591 NM_001032287
NM_001127362
NM_003297
NR2C1


nuclear receptor subfamily 2, group C, member 1


chr2_-_220034706 0.580 NM_001144889
NM_001144890
NM_144712
SLC23A3


solute carrier family 23 (nucleobase transporters), member 3


chr7_-_74489686 0.580 NM_030798
WBSCR16
Williams-Beuren syndrome chromosome region 16
chr20_+_44509847 0.580 NM_080603
ZSWIM1
zinc finger, SWIM-type containing 1
chr17_+_7123246 0.561 ACADVL
acyl-CoA dehydrogenase, very long chain
chr12_+_67663364 0.561 CAND1
cullin-associated and neddylation-dissociated 1
chr8_-_82607206 0.553 NM_001010893
SLC10A5
solute carrier family 10 (sodium/bile acid cotransporter family), member 5
chr7_-_74489572 0.551 WBSCR16
Williams-Beuren syndrome chromosome region 16
chr12_+_121416294 0.542 HNF1A
HNF1 homeobox A
chr1_+_43855549 0.540 NM_015284
SZT2
seizure threshold 2 homolog (mouse)
chr1_-_6761878 0.540 DNAJC11
DnaJ (Hsp40) homolog, subfamily C, member 11
chr1_-_6761839 0.539 DNAJC11
DnaJ (Hsp40) homolog, subfamily C, member 11
chr7_-_72936538 0.532 BAZ1B
bromodomain adjacent to zinc finger domain, 1B
chr2_+_207024317 0.520 NM_001037663
NM_001959
NM_021121
EEF1B2


eukaryotic translation elongation factor 1 beta 2


chr5_+_132209354 0.520 NM_052971
LEAP2
liver expressed antimicrobial peptide 2
chr1_-_6420719 0.517 NM_181865
ACOT7
acyl-CoA thioesterase 7
chr4_+_4543718 0.512 LOC100507266
uncharacterized LOC100507266
chr6_-_146285545 0.505 SHPRH
SNF2 histone linker PHD RING helicase
chr19_+_10197023 0.502 C19orf66
chromosome 19 open reading frame 66
chrX_-_18372777 0.501 NM_006089
SCML2
sex comb on midleg-like 2 (Drosophila)
chr10_+_120967094 0.497 NM_005308
GRK5
G protein-coupled receptor kinase 5
chr3_-_150264134 0.492 SERP1
stress-associated endoplasmic reticulum protein 1
chr3_-_194392938 0.490 LSG1
large subunit GTPase 1 homolog (S. cerevisiae)
chr22_+_41865112 0.480 NM_001098
ACO2
aconitase 2, mitochondrial
chr4_-_7069801 0.476 GRPEL1
GrpE-like 1, mitochondrial (E. coli)
chr6_+_30594607 0.474 NM_024909
NM_001031722
NM_001190724
ATAT1


alpha tubulin acetyltransferase 1


chr7_-_72936592 0.466 NM_032408
BAZ1B
bromodomain adjacent to zinc finger domain, 1B
chr17_-_7123368 0.465 NM_001365
DLG4
discs, large homolog 4 (Drosophila)
chr2_-_191399449 0.464 NM_001142645
TMEM194B
transmembrane protein 194B
chr19_+_45394569 0.456 TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr2_+_159313407 0.454 PKP4
plakophilin 4
chr17_-_1395950 0.453 NM_001080779
MYO1C
myosin IC
chr3_-_150264234 0.448 SERP1
stress-associated endoplasmic reticulum protein 1
chr6_-_31138180 0.447 NM_002701
POU5F1
POU5F1B
POU5F1P3
POU5F1P4
POU class 5 homeobox 1
POU class 5 homeobox 1B
POU class 5 homeobox 1 pseudogene 3
POU class 5 homeobox 1 pseudogene 4
chr6_+_31623688 0.447 APOM
apolipoprotein M
chr2_+_207024614 0.436 EEF1B2
eukaryotic translation elongation factor 1 beta 2
chr22_-_44893179 0.433 LDOC1L
leucine zipper, down-regulated in cancer 1-like
chr19_+_10196972 0.432 C19orf66
chromosome 19 open reading frame 66
chr1_+_43855599 0.427 SZT2
seizure threshold 2 homolog (mouse)
chr8_+_22436641 0.424 PDLIM2
PDZ and LIM domain 2 (mystique)
chr1_-_55089068 0.421 NM_176782
FAM151A
family with sequence similarity 151, member A
chr3_+_37284680 0.419 NM_001172713
NM_002078
GOLGA4

golgin A4

chr1_-_95538443 0.417 NM_144988
ALG14
asparagine-linked glycosylation 14 homolog (S. cerevisiae)
chr17_-_2614926 0.415 NM_015229
KIAA0664
KIAA0664
chrX_+_100354797 0.412 NM_006733
CENPI
centromere protein I
chr3_-_14166370 0.411 NM_001098502
NM_144636
CHCHD4

coiled-coil-helix-coiled-coil-helix domain containing 4

chr2_+_28113481 0.411 NM_199193
NM_199194
NM_004899
NM_199191
NM_199192
BRE




brain and reproductive organ-expressed (TNFRSF1A modulator)




chr3_-_14166292 0.410 CHCHD4
coiled-coil-helix-coiled-coil-helix domain containing 4
chr3_-_150264264 0.408 SERP1
stress-associated endoplasmic reticulum protein 1
chr4_+_156680603 0.402 GUCY1B3
guanylate cyclase 1, soluble, beta 3
chr17_+_38279468 0.400 MSL1
male-specific lethal 1 homolog (Drosophila)
chr20_+_36661849 0.400 NM_021215
RPRD1B
regulation of nuclear pre-mRNA domain containing 1B
chr19_+_36239261 0.397 NM_019104
LIN37
lin-37 homolog (C. elegans)
chr12_-_7079616 0.396 PHB2
prohibitin 2
chr2_+_109065576 0.392 NM_181453
GCC2
GRIP and coiled-coil domain containing 2
chr5_+_118965253 0.388 NM_001163991
NM_182761
FAM170A

family with sequence similarity 170, member A

chr12_+_67663147 0.387 CAND1
cullin-associated and neddylation-dissociated 1
chr2_+_109065665 0.386 GCC2
GRIP and coiled-coil domain containing 2
chr1_-_6761897 0.383 NM_018198
DNAJC11
DnaJ (Hsp40) homolog, subfamily C, member 11
chr6_+_142468382 0.365 VTA1
Vps20-associated 1 homolog (S. cerevisiae)
chr19_-_1020995 0.365 C19orf6
chromosome 19 open reading frame 6
chr1_-_226374401 0.364 NM_022735
ACBD3
acyl-CoA binding domain containing 3
chr5_+_14664803 0.361 FAM105B
family with sequence similarity 105, member B
chr6_-_2840683 0.361 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr9_-_139137646 0.360 NM_181701
QSOX2
quiescin Q6 sulfhydryl oxidase 2
chr2_-_178257380 0.355 LOC100130691
uncharacterized LOC100130691
chr19_+_2328679 0.354 SPPL2B
signal peptide peptidase-like 2B
chr1_-_40042461 0.353 PABPC4
poly(A) binding protein, cytoplasmic 4 (inducible form)
chr2_-_191399415 0.347 TMEM194B
transmembrane protein 194B
chr12_+_132413776 0.342 NM_001002019
NM_025215
PUS1

pseudouridylate synthase 1

chr18_-_51750460 0.340 MBD2
methyl-CpG binding domain protein 2
chr2_-_198364997 0.337 NM_199440
HSPD1
heat shock 60kDa protein 1 (chaperonin)
chr2_+_28113598 0.336 BRE
brain and reproductive organ-expressed (TNFRSF1A modulator)
chr1_-_40042519 0.336 NM_001135653
NM_001135654
NM_003819
PABPC4


poly(A) binding protein, cytoplasmic 4 (inducible form)


chr10_+_114133838 0.334 NM_203379
ACSL5
acyl-CoA synthetase long-chain family member 5
chr19_-_39390168 0.329 NM_012237
NM_001193286
NM_030593
SIRT2


sirtuin 2


chr16_+_81272293 0.327 NM_017429
BCMO1
beta-carotene 15,15'-monooxygenase 1
chr2_-_198364522 0.324 HSPD1
heat shock 60kDa protein 1 (chaperonin)
chr6_+_142468401 0.324 NM_016485
VTA1
Vps20-associated 1 homolog (S. cerevisiae)
chr5_+_14664764 0.321 NM_138348
FAM105B
family with sequence similarity 105, member B
chr6_+_31623668 0.316 NM_019101
APOM
apolipoprotein M
chr2_+_28113612 0.314 BRE
brain and reproductive organ-expressed (TNFRSF1A modulator)
chr4_-_102268333 0.312 PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr7_-_25164902 0.310 NM_018947
CYCS
cytochrome c, somatic
chr3_-_49314281 0.308 NM_198562
C3orf62
chromosome 3 open reading frame 62
chr12_+_50135953 0.306 TMBIM6
transmembrane BAX inhibitor motif containing 6
chr19_-_2328566 0.304 NM_016199
LSM7
LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
211.11 7.47e-03 GO:0032488 Cdc42 protein signal transduction
168.90 1.24e-02 GO:0010901 regulation of very-low-density lipoprotein particle remodeling
140.75 1.86e-02 GO:0044091 membrane biogenesis

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
30.92 9.79e-03 GO:0005778 peroxisomal membrane
30.92 9.79e-03 GO:0031903 microbody membrane
105.57 1.23e-02 GO:0034366 spherical high-density lipoprotein particle
20.79 3.20e-02 GO:0044438 microbody part
20.79 3.20e-02 GO:0044439 peroxisomal part
64.98 3.40e-02 GO:0005779 integral to peroxisomal membrane
64.98 3.40e-02 GO:0031231 intrinsic to peroxisomal membrane
3.42 3.51e-02 GO:0005739 mitochondrion

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
281.48 9.16e-04 GO:0070653 high-density lipoprotein particle receptor binding