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• Mean activities

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• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)
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Motif ID: REST.p3

Z-value: 1.687

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr9_+_135457974	18.482	NM_020064	BARHL1	BarH-like homeobox 1
chr20_+_30555804	15.614	NM_001011718	XKR7	XK, Kell blood group complex subunit-related family, member 7
chr12_+_175872	14.270	NM_001170738	IQSEC3	IQ motif and Sec7 domain 3
chr20_-_10200137	13.121		LOC100131208	uncharacterized LOC100131208
chrX_-_47479229	10.357	NM_006950 NM_133499	SYN1	synapsin I
chr3_+_9745509	10.091	NM_153635	CPNE9	copine family member IX
chr15_-_72612469	9.528		CELF6	CUGBP, Elav-like family member 6
chr20_-_60795270	9.370	NM_007232	HRH3	histamine receptor H3
chr5_+_71014989	9.352	NM_004291	CARTPT	CART prepropeptide
chr8_-_145559831	9.289	NM_031309	SCRT1	scratch homolog 1, zinc finger protein (Drosophila)
chr1_+_210111537	9.043	NM_001146261 NM_001146262 NM_001146264 NM_153262	SYT14	synaptotagmin XIV
chrX_-_47479095	8.913
chr4_+_8582216	8.892	NM_080819	GPR78	G protein-coupled receptor 78
chr15_-_72612497	8.691	NM_052840	CELF6	CUGBP, Elav-like family member 6
chr12_+_119419299	8.579	NM_194286	SRRM4	serine/arginine repetitive matrix 4
chr19_-_55691468	8.437	NM_003180	SYT5	synaptotagmin V
chr3_+_62304667	8.374		C3orf14	chromosome 3 open reading frame 14
chr19_+_41036430	8.362		SPTBN4	spectrin, beta, non-erythrocytic 4
chr9_+_138453599	8.147	NM_001018049 NM_002571	PAEP	progestagen-associated endometrial protein
chr9_-_74061819	8.135		TRPM3	transient receptor potential cation channel, subfamily M, member 3
chr6_+_110300197	7.888	NM_005284	GPR6	G protein-coupled receptor 6
chr20_+_44657812	7.844	NM_020708	SLC12A5	solute carrier family 12 (potassium/chloride transporter), member 5
chr4_+_158141735	7.795	NM_000826 NM_001083619 NM_001083620	GRIA2	glutamate receptor, ionotropic, AMPA 2
chr11_-_75141210	7.791		KLHL35	kelch-like 35 (Drosophila)
chr11_-_75141517	7.781	NM_001039548	KLHL35	kelch-like 35 (Drosophila)
chr1_+_210111575	7.748		SYT14	synaptotagmin XIV
chr3_+_120627026	7.718	NM_014980	STXBP5L	syntaxin binding protein 5-like
chr4_-_175750377	7.640	NM_001042543 NM_006529	GLRA3	glycine receptor, alpha 3
chr16_+_24267474	7.619		CACNG3	calcium channel, voltage-dependent, gamma subunit 3
chr3_+_62305395	7.588	NM_020685	C3orf14	chromosome 3 open reading frame 14
chr5_-_151304322	7.535	NM_000171 NM_001146040	GLRA1	glycine receptor, alpha 1
chr14_-_51562044	7.335		TRIM9	tripartite motif containing 9
chr5_+_33936490	7.333	NM_016568	RXFP3	relaxin/insulin-like family peptide receptor 3
chr1_+_154540250	7.305	NM_000748	CHRNB2	cholinergic receptor, nicotinic, beta 2 (neuronal)
chr9_-_139096954	7.293	NM_178138	LHX3	LIM homeobox 3
chr6_+_154360442	7.291	NM_000914 NM_001008503 NM_001008504 NM_001008505 NM_001145282 NM_001145283 NM_001145284 NM_001145285 NM_001145286	OPRM1	opioid receptor, mu 1
chr14_-_74892804	7.278	NM_001105579	SYNDIG1L	synapse differentiation inducing 1-like
chr15_-_72612127	7.247		CELF6	CUGBP, Elav-like family member 6
chr5_-_135701163	7.168	NM_001167576 NM_001167577 NM_020389	TRPC7	transient receptor potential cation channel, subfamily C, member 7
chr7_+_145813452	7.159	NM_014141	CNTNAP2	contactin associated protein-like 2
chr6_+_35773070	7.144	NM_182548	LHFPL5	lipoma HMGIC fusion partner-like 5
chr20_+_44657858	7.039		SLC12A5	solute carrier family 12 (potassium/chloride transporter), member 5
chr6_+_25652373	7.017	NM_006998	SCGN	secretagogin, EF-hand calcium binding protein
chr9_+_140033588	6.996	NM_000832 NM_001185090 NM_001185091 NM_007327 NM_021569	GRIN1	glutamate receptor, ionotropic, N-methyl D-aspartate 1
chr19_+_41036367	6.984	NM_025213	SPTBN4	spectrin, beta, non-erythrocytic 4
chr1_-_241520467	6.723	NM_002924	RGS7	regulator of G-protein signaling 7
chr2_-_51259239	6.677		NRXN1	neurexin 1
chr15_-_27018917	6.630	NM_021912	GABRB3	gamma-aminobutyric acid (GABA) A receptor, beta 3
chr12_+_113229548	6.463	NM_001143854 NM_014954	RPH3A	rabphilin 3A homolog (mouse)
chr16_+_5008317	6.444	NM_014692	SEC14L5	SEC14-like 5 (S. cerevisiae)
chr12_+_113229713	6.417		RPH3A	rabphilin 3A homolog (mouse)
chr1_+_154540300	6.204		CHRNB2	cholinergic receptor, nicotinic, beta 2 (neuronal)
chr10_+_73555527	6.133	NM_001171933 NM_001171934	CDH23	cadherin-related 23
chr17_-_27332888	6.065	NM_001098635 NM_178860	SEZ6	seizure related 6 homolog (mouse)
chr5_+_175298538	6.021		CPLX2	complexin 2
chr11_-_75141015	5.953		KLHL35	kelch-like 35 (Drosophila)
chr8_-_91094924	5.918	NM_004929	CALB1	calbindin 1, 28kDa
chr14_+_93389444	5.910	NM_001275	CHGA	chromogranin A (parathyroid secretory protein 1)
chr14_-_51561657	5.747		TRIM9	tripartite motif containing 9
chr11_+_22359666	5.639	NM_020346	SLC17A6	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr17_+_42385780	5.434	NM_001144825 NM_001144826 NM_006695	RUNDC3A	RUN domain containing 3A
chr1_-_175712669	5.400	NM_003285	TNR	tenascin R (restrictin, janusin)
chr19_-_40724272	5.382	NM_152479	TTC9B	tetratricopeptide repeat domain 9B
chr2_-_51259536	5.232	NM_001135659 NM_004801	NRXN1	neurexin 1
chr5_+_175298492	5.170	NM_001008220	CPLX2	complexin 2
chr5_+_175298604	5.040		CPLX2	complexin 2
chr1_+_33352071	5.033	NM_002143	HPCA	hippocalcin
chr1_-_151689246	4.986	NM_007185	CELF3	CUGBP, Elav-like family member 3
chr17_+_72667316	4.897		RAB37	RAB37, member RAS oncogene family
chr20_+_5891973	4.808	NM_001819	CHGB	chromogranin B (secretogranin 1)
chr1_-_153123426	4.790	NM_001014291	SPRR2G	small proline-rich protein 2G
chr15_+_68117940	4.748	NM_001031807	SKOR1	SKI family transcriptional corepressor 1
chr17_+_72667255	4.355	NM_175738	RAB37	RAB37, member RAS oncogene family
chr15_-_32162896	4.107		OTUD7A	OTU domain containing 7A
chr2_-_27531113	4.088	NM_003353	UCN	urocortin
chr5_-_176037091	4.061	NM_052899	GPRIN1	G protein regulated inducer of neurite outgrowth 1
chr11_-_125773086	3.998	NM_031307	PUS3	pseudouridylate synthase 3
chr10_-_102790850	3.934		PDZD7	PDZ domain containing 7
chr2_-_42720476	3.930		KCNG3	potassium voltage-gated channel, subfamily G, member 3
chr2_-_220083658	3.897		ABCB6	ATP-binding cassette, sub-family B (MDR/TAP), member 6
chr14_-_94759594	3.799	NM_001100607	SERPINA10	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr14_-_58332591	3.658	NM_001206920	SLC35F4	solute carrier family 35, member F4
chr17_+_30813928	3.584	NM_003885	CDK5R1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr11_+_637268	3.493	NM_000797	DRD4	dopamine receptor D4
chr2_-_220083394	3.034		ABCB6	ATP-binding cassette, sub-family B (MDR/TAP), member 6
chr11_-_27742224	2.871	NM_001143805 NM_001143806 NM_170732	BDNF	brain-derived neurotrophic factor
chr1_-_241520384	2.654		RGS7	regulator of G-protein signaling 7
chr10_+_60937226	2.588	NM_001143774	PHYHIPL	phytanoyl-CoA 2-hydroxylase interacting protein-like
chr9_-_104357202	2.433	NM_147180	PPP3R2	protein phosphatase 3, regulatory subunit B, beta
chr2_+_131513782	2.104	NM_001105194 NM_001105195	FAM123C	family with sequence similarity 123C
chr19_-_45737466	1.970	NM_138568	EXOC3L2	exocyst complex component 3-like 2
chr20_-_62284701	1.937	NM_015894	STMN3	stathmin-like 3
chr11_-_27721179	1.935	NM_170734	BDNF	brain-derived neurotrophic factor
chr6_+_153071931	1.851	NM_003381 NM_194435	VIP	vasoactive intestinal peptide
chr1_-_33336289	1.703	NM_001171940 NM_153756	FNDC5	fibronectin type III domain containing 5
chr6_+_43603554	1.648	NM_014628	MAD2L1BP	MAD2L1 binding protein
chr21_-_35828038	1.464	NM_001127670	KCNE1	potassium voltage-gated channel, Isk-related family, member 1
chr2_-_96810775	1.454		DUSP2	dual specificity phosphatase 2
chr15_-_32162778	1.443		OTUD7A	OTU domain containing 7A
chr19_-_39402797	1.431	NM_001243212	LOC643669	uncharacterized LOC643669
chr10_-_50970321	1.352	NM_001143996 NM_001143997 NM_018245	OGDHL	oxoglutarate dehydrogenase-like
chr11_-_6676851	1.322	NM_003737	DCHS1	dachsous 1 (Drosophila)
chr12_+_71833518	1.275		LGR5	leucine-rich repeat containing G protein-coupled receptor 5
chr6_+_43603588	1.269		MAD2L1BP	MAD2L1 binding protein
chr8_-_145752405	1.122	NM_001024678	LRRC24	leucine rich repeat containing 24
chr17_+_80332152	1.022	NM_018949	UTS2R	urotensin 2 receptor
chr8_+_68864341	0.971		PREX2	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr19_+_15197790	0.889	NM_001004713	OR1I1	olfactory receptor, family 1, subfamily I, member 1
chr14_+_93389491	0.886		CHGA	chromogranin A (parathyroid secretory protein 1)
chr19_-_45926819	0.854	NM_202001	ERCC1	excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr19_-_45926759	0.839		ERCC1	excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr8_+_6565870	0.709	NM_018361	AGPAT5	1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon)
chr12_+_51347781	0.672	NM_001109619	HIGD1C	HIG1 hypoxia inducible domain family, member 1C
chr6_+_44238479	0.582	NM_001137560	TMEM151B	transmembrane protein 151B
chr11_-_128807712	0.571	NM_001195194	TP53AIP1	tumor protein p53 regulated apoptosis inducing protein 1
chr19_-_45927175	0.550	NM_001166049 NM_001983	ERCC1	excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr16_+_3019341	0.427	NM_152341	PAQR4	progestin and adipoQ receptor family member IV
chr11_-_1769086	0.387		IFITM10	interferon induced transmembrane protein 10
chr8_+_6565914	0.357		AGPAT5	1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon)
chr8_+_6566153	0.166		AGPAT5	1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon)
chr16_+_2510080	0.164	NM_025108	C16orf59	chromosome 16 open reading frame 59
chr19_-_3971032	0.160		DAPK3	death-associated protein kinase 3
chr16_+_67686813	0.144		RLTPR	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
chr1_-_241683060	0.089	NM_000143	FH	fumarate hydratase
chr17_-_65362667	0.082	NM_002816 NM_174871	PSMD12	proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
chr1_-_241683011	0.074		FH	fumarate hydratase
chr20_-_13765509	0.048	NM_016649	ESF1	ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)

Gene overrepresentation in process category:

Enrichment	P-value	GO Accession	GO Term
8.56	3.08e-09	GO:0019226	transmission of nerve impulse
8.56	3.08e-09	GO:0035637	multicellular organismal signaling
9.04	6.11e-09	GO:0007268	synaptic transmission
4.19	6.73e-07	GO:0050877	neurological system process
7.72	1.04e-06	GO:0055082	cellular chemical homeostasis
3.65	1.85e-06	GO:0003008	system process
7.42	6.58e-06	GO:0006873	cellular ion homeostasis
6.39	1.14e-05	GO:0019725	cellular homeostasis
5.26	1.55e-05	GO:0007267	cell-cell signaling
6.85	1.69e-05	GO:0050801	ion homeostasis
8.61	2.07e-05	GO:0007610	behavior
5.65	5.26e-05	GO:0048878	chemical homeostasis
5.88	1.00e-04	GO:0007186	G-protein coupled receptor protein signaling pathway
4.22	1.33e-04	GO:0007154	cell communication
11.52	9.71e-04	GO:0031644	regulation of neurological system process
37.54	1.42e-03	GO:0060078	regulation of postsynaptic membrane potential
6.64	3.19e-03	GO:0055080	cation homeostasis
3.98	3.40e-03	GO:0042592	homeostatic process
6.57	3.45e-03	GO:0044057	regulation of system process
2.09	5.75e-03	GO:0023052	signaling
8.49	7.25e-03	GO:0055074	calcium ion homeostasis
10.91	7.27e-03	GO:0051969	regulation of transmission of nerve impulse
6.89	8.07e-03	GO:0055065	metal ion homeostasis
10.65	8.33e-03	GO:0042391	regulation of membrane potential
24.35	8.45e-03	GO:0051952	regulation of amine transport
8.18	9.20e-03	GO:0072507	divalent inorganic cation homeostasis
51.97	9.35e-03	GO:0051954	positive regulation of amine transport
22.53	1.16e-02	GO:0051899	membrane depolarization
6.47	1.27e-02	GO:0030003	cellular cation homeostasis
3.66	1.80e-02	GO:0006811	ion transport
12.12	2.29e-02	GO:0007626	locomotory behavior
1.77	2.48e-02	GO:0032501	multicellular organismal process
2.46	2.58e-02	GO:0065008	regulation of biological quality
5.04	2.78e-02	GO:0046903	secretion
10.84	3.91e-02	GO:0008217	regulation of blood pressure
10.53	4.47e-02	GO:0007611	learning or memory
30.72	4.89e-02	GO:0014073	response to tropane
30.72	4.89e-02	GO:0042220	response to cocaine

Gene overrepresentation in compartment category:

Enrichment	P-value	GO Accession	GO Term
7.56	1.30e-06	GO:0045202	synapse
8.61	5.07e-06	GO:0044456	synapse part
6.48	8.80e-05	GO:0043005	neuron projection
9.59	1.72e-04	GO:0030425	dendrite
15.54	2.29e-04	GO:0008021	synaptic vesicle
4.78	6.44e-04	GO:0030054	cell junction
9.28	9.88e-04	GO:0043025	neuronal cell body
9.02	1.19e-03	GO:0044297	cell body
7.59	3.63e-03	GO:0034702	ion channel complex
3.96	4.15e-03	GO:0016023	cytoplasmic membrane-bounded vesicle
2.44	4.37e-03	GO:0044459	plasma membrane part
20.03	4.54e-03	GO:0030672	synaptic vesicle membrane
9.14	4.83e-03	GO:0045211	postsynaptic membrane
3.89	4.98e-03	GO:0031988	membrane-bounded vesicle
3.59	5.32e-03	GO:0042995	cell projection
39.75	5.36e-03	GO:0032589	neuron projection membrane
3.73	7.46e-03	GO:0031410	cytoplasmic vesicle
8.40	7.71e-03	GO:0030136	clathrin-coated vesicle
1.88	8.46e-03	GO:0005886	plasma membrane
3.61	1.02e-02	GO:0031982	vesicle
1.86	1.13e-02	GO:0071944	cell periphery
112.59	1.15e-02	GO:0032590	dendrite membrane
6.12	1.41e-02	GO:0030659	cytoplasmic vesicle membrane
5.92	1.74e-02	GO:0012506	vesicle membrane
6.87	2.32e-02	GO:0030135	coated vesicle
5.08	4.38e-02	GO:0044433	cytoplasmic vesicle part

Gene overrepresentation in function category:

Enrichment	P-value	GO Accession	GO Term
18.78	7.38e-05	GO:0005230	extracellular ligand-gated ion channel activity
23.97	1.92e-04	GO:0005231	excitatory extracellular ligand-gated ion channel activity
3.38	6.72e-04	GO:0005215	transporter activity
10.82	1.84e-03	GO:0015276	ligand-gated ion channel activity
10.82	1.84e-03	GO:0022834	ligand-gated channel activity
51.97	2.26e-03	GO:0016594	glycine binding
5.33	4.36e-03	GO:0005216	ion channel activity
5.25	4.92e-03	GO:0022838	substrate-specific channel activity
6.00	5.24e-03	GO:0022836	gated channel activity
5.09	6.23e-03	GO:0015267	channel activity
5.08	6.35e-03	GO:0022803	passive transmembrane transporter activity
112.59	1.13e-02	GO:0016933	extracellular-glycine-gated ion channel activity
112.59	1.13e-02	GO:0016934	extracellular-glycine-gated chloride channel activity
90.08	1.89e-02	GO:0022824	transmitter-gated ion channel activity
90.08	1.89e-02	GO:0022835	transmitter-gated channel activity
9.17	2.08e-02	GO:0043176	amine binding
3.29	2.39e-02	GO:0022891	substrate-specific transmembrane transporter activity
3.52	2.51e-02	GO:0015075	ion transmembrane transporter activity
75.07	2.82e-02	GO:0005237	inhibitory extracellular ligand-gated ion channel activity
3.05	4.76e-02	GO:0022857	transmembrane transporter activity