Motif ID: RBPJ.p2

Z-value: 0.734


Transcription factors associated with RBPJ.p2:

Gene SymbolEntrez IDGene Name
RBPJ 3516 recombination signal binding protein for immunoglobulin kappa J region

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
RBPJhg19_v1_chr4_+_26322627_263226460.208.4e-02Click!


Activity profile for motif RBPJ.p2.

activity profile for motif RBPJ.p2


Sorted Z-values histogram for motif RBPJ.p2

Sorted Z-values for motif RBPJ.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RBPJ.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_-_44144151 11.125 NM_001005368
ZNF32
zinc finger protein 32
chr10_-_44144266 8.119 NM_006973
ZNF32
zinc finger protein 32
chr19_-_51504799 5.369 NM_007196
NM_144505
NM_144506
NM_144507
KLK8



kallikrein-related peptidase 8



chr2_-_160761192 5.255 LY75-CD302
LY75
LY75-CD302 readthrough
lymphocyte antigen 75
chr19_+_44488331 4.939 NM_003445
NM_198089
ZNF155

zinc finger protein 155

chr11_+_43963809 4.420 NM_001145033
C11orf96
chromosome 11 open reading frame 96
chr19_+_37407230 3.769 NM_001204835
NM_001204836
NM_001204837
NM_001204838
NM_001204839
NM_198539
ZNF568





zinc finger protein 568





chr5_-_137514299 3.759 NM_001164326
NM_006696
NM_139199
BRD8


bromodomain containing 8


chr2_-_160761266 3.711 NM_001198759
NM_001198760
NM_002349
LY75-CD302

LY75
LY75-CD302 readthrough

lymphocyte antigen 75
chr17_+_7942351 3.465 NM_001039130
NM_001039131
NM_001141
ALOX15B


arachidonate 15-lipoxygenase, type B


chr5_+_137514753 3.443 KIF20A
kinesin family member 20A
chr7_-_139168408 3.152 NM_198508
KLRG2
killer cell lectin-like receptor subfamily G, member 2
chr17_-_34257730 3.103 NM_001034836
NM_001163120
NM_001163121
NM_145654
RDM1



RAD52 motif 1



chr19_+_36980524 2.983 LOC728752
uncharacterized LOC728752
chr4_-_55991746 2.926 NM_002253
KDR
kinase insert domain receptor (a type III receptor tyrosine kinase)
chr20_-_1165116 2.834 NM_018354
TMEM74B
transmembrane protein 74B
chr9_-_123688352 2.734 TRAF1
TNF receptor-associated factor 1
chr19_+_37341259 2.705 NM_003419
ZNF345
zinc finger protein 345
chrX_-_153095996 2.672 NM_032512
PDZD4
PDZ domain containing 4
chr19_+_35168558 2.634 NM_001012320
NM_018443
ZNF302

zinc finger protein 302

chr17_-_27949814 2.507 CORO6
coronin 6
chr17_-_34257285 2.483 NM_001163122
NM_001163124
NM_001163125
NM_001163130
RDM1



RAD52 motif 1



chr1_+_149871154 2.435 NM_016074
BOLA1
bolA homolog 1 (E. coli)
chr5_+_178450775 2.376 NM_001136116
ZNF879
zinc finger protein 879
chr19_-_37407079 2.364 NM_001037232
ZNF829
zinc finger protein 829
chr19_-_37406918 2.273 NM_001171979
ZNF829
zinc finger protein 829
chr16_+_23765947 2.267 NM_022097
CHP2
calcineurin B homologous protein 2
chr2_+_237478379 2.263 NM_020311
CXCR7
chemokine (C-X-C motif) receptor 7
chr5_+_42423811 2.158 NM_000163
GHR
growth hormone receptor
chr12_-_104443698 2.131 GLT8D2
glycosyltransferase 8 domain containing 2
chr9_-_34522972 2.088 NM_198573
ENHO
energy homeostasis associated
chr5_+_180257979 2.054 LOC729678
uncharacterized LOC729678
chr19_-_58514136 1.995 ZNF606
zinc finger protein 606
chr11_+_111789600 1.955 NM_080659
C11orf52
chromosome 11 open reading frame 52
chr14_+_77228940 1.954 VASH1
vasohibin 1
chr19_-_37341168 1.919 NM_001242801
ZNF790
zinc finger protein 790
chr1_-_45805606 1.873 NM_001048174
NM_001048172
NM_001048173
NM_001048171
NM_001128425
NM_012222
MUTYH





mutY homolog (E. coli)





chr16_-_30103204 1.853 NM_004608
TBX6
T-box 6
chr19_-_37958338 1.844 NM_152484
ZNF569
zinc finger protein 569
chr5_+_180257936 1.823


chr19_-_10625679 1.779 S1PR5
sphingosine-1-phosphate receptor 5
chr14_-_21493122 1.761 NM_201538
NM_201539
NM_201540
NM_201541
NDRG2



NDRG family member 2



chr19_+_37569307 1.760 NM_144689
ZNF420
zinc finger protein 420
chr12_+_133707212 1.730 NM_015394
ZNF10
zinc finger protein 10
chr10_-_38146221 1.705 NM_021045
ZNF248
zinc finger protein 248
chr12_+_109577201 1.686 NM_001093
ACACB
acetyl-CoA carboxylase beta
chr19_+_5681016 1.684 NM_198704
NM_198705
NM_198533
NM_198707
NM_198706
NM_198708
HSD11B1L





hydroxysteroid (11-beta) dehydrogenase 1-like





chr17_-_7991020 1.629 NM_001139
ALOX12B
arachidonate 12-lipoxygenase, 12R type
chrX_+_105969875 1.623 NM_194463
RNF128
ring finger protein 128
chr5_+_137514416 1.621 NM_005733
KIF20A
kinesin family member 20A
chr9_-_123689172 1.600 NM_005658
TRAF1
TNF receptor-associated factor 1
chr18_+_6834431 1.594 NM_001010000
ARHGAP28
Rho GTPase activating protein 28
chr19_+_40502942 1.577 NM_178544
ZNF546
zinc finger protein 546
chr20_+_42143045 1.551 NM_015478
L3MBTL1
l(3)mbt-like 1 (Drosophila)
chr19_-_36980336 1.534 NM_032838
NM_001145343
NM_001145344
NM_001145345
ZNF566



zinc finger protein 566



chr11_+_94706780 1.529 NM_018039
KDM4D
lysine (K)-specific demethylase 4D
chr20_-_44420538 1.498 NM_080614
WFDC3
WAP four-disulfide core domain 3
chr14_+_73704204 1.493 NM_173462
PAPLN
papilin, proteoglycan-like sulfated glycoprotein
chr12_-_49259549 1.493 NM_014470
RND1
Rho family GTPase 1
chr9_-_123676849 1.483 NM_001190947
TRAF1
TNF receptor-associated factor 1
chr19_+_5681139 1.483 HSD11B1L
hydroxysteroid (11-beta) dehydrogenase 1-like
chrX_-_153095332 1.474 PDZD4
PDZ domain containing 4
chr8_+_79428335 1.461 NM_006823
NM_181839
PKIA

protein kinase (cAMP-dependent, catalytic) inhibitor alpha

chr9_-_86571652 1.458 NM_032307
C9orf64
chromosome 9 open reading frame 64
chr3_-_99833348 1.431 NM_001042459
NM_182909
FILIP1L

filamin A interacting protein 1-like

chr2_+_218990735 1.417 NM_001557
CXCR2
chemokine (C-X-C motif) receptor 2
chr5_+_178322915 1.407 NM_030613
ZFP2
zinc finger protein 2 homolog (mouse)
chrX_-_153095841 1.403 PDZD4
PDZ domain containing 4
chr5_+_140306301 1.399 NM_018898
NM_031882
PCDHAC1

protocadherin alpha subfamily C, 1

chr20_+_123230 1.361 NM_030931
DEFB126
defensin, beta 126
chr6_+_43968303 1.343 NM_001171992
NM_153246
C6orf223

chromosome 6 open reading frame 223

chr5_-_139943829 1.293 APBB3
amyloid beta (A4) precursor protein-binding, family B, member 3
chr1_-_150980840 1.290 NM_001163258
NM_018379
FAM63A

family with sequence similarity 63, member A

chr7_-_16844606 1.287 NM_006408
AGR2
anterior gradient 2 homolog (Xenopus laevis)
chr12_-_104443914 1.284 NM_031302
GLT8D2
glycosyltransferase 8 domain containing 2
chr12_-_57146081 1.256 NM_000946
PRIM1
primase, DNA, polypeptide 1 (49kDa)
chr4_-_84256304 1.236 NM_001166498
NM_006665
HPSE

heparanase

chr20_+_33146500 1.228 NM_032514
MAP1LC3A
microtubule-associated protein 1 light chain 3 alpha
chr21_+_46875402 1.224 NM_030582
COL18A1
collagen, type XVIII, alpha 1
chr11_-_61129462 1.218 NM_001161454
NM_153611
CYBASC3

cytochrome b, ascorbate dependent 3

chr3_+_101546833 1.217 NM_001005474
NFKBIZ
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr17_+_43238263 1.216 NM_144608
HEXIM2
hexamethylene bis-acetamide inducible 2
chr4_-_52883785 1.215 NM_001024611
LRRC66
leucine rich repeat containing 66
chr19_-_10628606 1.200 NM_001166215
S1PR5
sphingosine-1-phosphate receptor 5
chr19_-_36870064 1.189 NM_020917
ZFP14
zinc finger protein 14 homolog (mouse)
chr19_-_7698569 1.165 NM_174895
PCP2
Purkinje cell protein 2
chr11_-_58345593 1.165 NM_001143995
LPXN
leupaxin
chr19_+_5904842 1.163 NM_001017921
VMAC
vimentin-type intermediate filament associated coiled-coil protein
chr15_+_90895476 1.152 NM_001004309
ZNF774
zinc finger protein 774
chr4_-_84256012 1.138 NM_001098540
HPSE
heparanase
chr9_+_22446783 1.129 NM_022160
DMRTA1
DMRT-like family A1
chr3_+_183353355 1.120 NM_017644
KLHL24
kelch-like 24 (Drosophila)
chr9_-_86571631 1.101 C9orf64
chromosome 9 open reading frame 64
chr16_+_69984809 1.100 NM_182619
CLEC18C
CLEC18A
C-type lectin domain family 18, member C
C-type lectin domain family 18, member A
chr1_+_155100304 1.099 NM_004428
NM_182685
EFNA1

ephrin-A1

chr2_+_120189342 1.095 NM_183240
TMEM37
transmembrane protein 37
chr17_+_44590075 1.087 NM_001006607
LRRC37A2
LRRC37A
leucine rich repeat containing 37, member A2
leucine rich repeat containing 37A
chr16_+_55358470 1.085 NM_024335
IRX6
iroquois homeobox 6
chr18_-_28622624 1.083 NM_001941
NM_024423
DSC3

desmocollin 3

chr12_-_85430054 1.066 NM_001100917
TSPAN19
tetraspanin 19
chr16_+_23313590 1.059 NM_000336
SCNN1B
sodium channel, nonvoltage-gated 1, beta
chr1_-_23810627 1.044 ASAP3
ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
chr7_+_1127722 1.042 NM_001098201
GPER
G protein-coupled estrogen receptor 1
chr19_-_36980758 1.027 ZNF566
zinc finger protein 566
chr5_-_159797618 1.011 NM_031908
C1QTNF2
C1q and tumor necrosis factor related protein 2
chrX_-_106960268 1.005 NM_004089
TSC22D3
TSC22 domain family, member 3
chr3_+_69812961 1.004 NM_006722
MITF
microphthalmia-associated transcription factor
chr1_+_212208918 0.982 NM_016448
DTL
denticleless homolog (Drosophila)
chr11_-_61129273 0.977 CYBASC3
cytochrome b, ascorbate dependent 3
chr4_-_1685717 0.974 NM_001013622
NM_001174070
FAM53A

family with sequence similarity 53, member A

chr19_+_13080431 0.968 NM_152654
DAND5
DAN domain family, member 5
chr12_+_70759974 0.963 NM_014505
KCNMB4
potassium large conductance calcium-activated channel, subfamily M, beta member 4
chr1_+_142618798 0.958


chr20_-_62130390 0.956 NM_001958
EEF1A2
eukaryotic translation elongation factor 1 alpha 2
chr16_+_23690191 0.955 NM_005030
PLK1
polo-like kinase 1
chr5_+_140792507 0.953 NM_018913
NM_032090
PCDHGA10

protocadherin gamma subfamily A, 10

chr1_+_36689996 0.951 NM_005119
THRAP3
thyroid hormone receptor associated protein 3
chr19_-_51456159 0.951 NM_001077491
NM_001077492
NM_012427
KLK5


kallikrein-related peptidase 5


chr16_+_23690234 0.946 PLK1
polo-like kinase 1
chr22_-_31688329 0.938 NM_001135911
NM_052880
PIK3IP1

phosphoinositide-3-kinase interacting protein 1

chr10_+_94352809 0.936 NM_004523
KIF11
kinesin family member 11
chr17_+_80693398 0.935 NM_022158
FN3K
fructosamine 3 kinase
chr3_+_69812620 0.935 NM_001184967
MITF
microphthalmia-associated transcription factor
chr16_+_23690212 0.932 PLK1
polo-like kinase 1
chr11_-_61129352 0.931 CYBASC3
cytochrome b, ascorbate dependent 3
chr20_+_8112762 0.929 NM_015192
NM_182734
PLCB1

phospholipase C, beta 1 (phosphoinositide-specific)

chr17_-_42092319 0.927 NM_032376
TMEM101
transmembrane protein 101
chr19_+_50706868 0.924 NM_001077186
NM_001145809
NM_024729
MYH14


myosin, heavy chain 14, non-muscle


chr19_-_44405934 0.923 LOC100505715
uncharacterized LOC100505715
chr1_-_93811322 0.909 LOC100131564
uncharacterized LOC100131564
chr16_+_23690190 0.906 PLK1
polo-like kinase 1
chr1_+_212209112 0.905 DTL
denticleless homolog (Drosophila)
chr16_+_23690160 0.905 PLK1
polo-like kinase 1
chr17_+_1648262 0.901 SERPINF2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr4_-_84255895 0.895 NM_001199830
HPSE
heparanase
chr16_+_640172 0.894 NM_021168
RAB40C
RAB40C, member RAS oncogene family
chr19_+_14544100 0.885 NM_002741
PKN1
protein kinase N1
chr17_+_80317122 0.884 NM_207459
TEX19
testis expressed 19
chr4_-_84255999 0.880 HPSE
heparanase
chr1_+_212209129 0.877 DTL
denticleless homolog (Drosophila)
chr10_+_111765725 0.876 NM_019903
ADD3
adducin 3 (gamma)
chr14_-_54421269 0.871 NM_130851
BMP4
bone morphogenetic protein 4
chr20_-_33460558 0.864 NM_178026
GGT7
gamma-glutamyltransferase 7
chr11_-_113746205 0.860 NM_020886
USP28
ubiquitin specific peptidase 28
chr9_+_90112754 0.852 NM_004938
DAPK1
death-associated protein kinase 1
chr9_-_86432546 0.850 NM_001135953
NM_025211
GKAP1

G kinase anchoring protein 1

chr1_+_201979689 0.846 NM_001114309
NM_004433
ELF3

E74-like factor 3 (ets domain transcription factor, epithelial-specific )

chr9_-_85677784 0.841 RASEF
RAS and EF-hand domain containing
chr1_+_152758752 0.839 NM_178353
LCE1E
late cornified envelope 1E
chr15_+_67835002 0.837 NM_002757
NM_145160
MAP2K5

mitogen-activated protein kinase kinase 5

chr9_+_136325086 0.832 NM_001135775
NM_001242369
NM_001242370
NM_017586
C9orf7



chromosome 9 open reading frame 7



chr7_-_99381703 0.832 NM_001202855
NM_017460
CYP3A4

cytochrome P450, family 3, subfamily A, polypeptide 4

chr3_+_112931374 0.829 NM_033254
BOC
Boc homolog (mouse)
chr7_+_8008416 0.828 NM_138426
GLCCI1
glucocorticoid induced transcript 1
chr17_-_46035109 0.820 NM_024320
PRR15L
proline rich 15-like
chr21_-_43187197 0.818 NM_020639
RIPK4
receptor-interacting serine-threonine kinase 4
chr19_-_58892382 0.817 NM_001129730
NM_138466
ZNF837

zinc finger protein 837

chr4_-_57976516 0.814 IGFBP7
insulin-like growth factor binding protein 7
chr16_+_639356 0.814 NM_001172663
RAB40C
RAB40C, member RAS oncogene family
chr3_-_187452669 0.814 NM_001134738
BCL6
B-cell CLL/lymphoma 6
chrX_+_123094377 0.811 NM_001042749
STAG2
stromal antigen 2
chr2_+_48844936 0.809 NM_001193487
NM_006872
GTF2A1L

general transcription factor IIA, 1-like

chr22_+_27068690 0.802 LOC100507637
uncharacterized LOC100507637
chr6_+_79787548 0.796 PHIP
pleckstrin homology domain interacting protein
chr5_-_112630557 0.793 NM_002387
MCC
mutated in colorectal cancers
chr15_+_45028559 0.791 NM_080745
NM_182985
TRIM69

tripartite motif containing 69

chr6_-_36355342 0.789 NM_001207038
NM_001207035
NM_001207036
NM_001207037
NM_001207039
NM_001207040
NM_001207041
NM_016135
ETV7







ets variant 7







chrX_+_24483343 0.788 NM_001142386
NM_005391
PDK3

pyruvate dehydrogenase kinase, isozyme 3

chr1_-_186344241 0.787 TPR
translocated promoter region (to activated MET oncogene)
chr15_+_40697977 0.786 IVD
isovaleryl-CoA dehydrogenase
chr11_-_82782883 0.784 NM_014488
RAB30
RAB30, member RAS oncogene family
chr17_+_46125675 0.776 NM_003204
NFE2L1
nuclear factor (erythroid-derived 2)-like 1
chr11_-_82782870 0.771 RAB30
RAB30, member RAS oncogene family
chr15_+_43622871 0.770 NM_001012969
NM_001159280
ADAL

adenosine deaminase-like

chr10_+_94352873 0.768 KIF11
kinesin family member 11
chr10_-_72141347 0.768 NM_207119
LRRC20
leucine rich repeat containing 20
chr17_+_39994042 0.764 NM_152467
KLHL10
kelch-like 10 (Drosophila)
chr12_-_59314069 0.764 NM_153377
LRIG3
leucine-rich repeats and immunoglobulin-like domains 3
chr17_-_26926044 0.761 NM_006461
SPAG5
sperm associated antigen 5
chr19_-_58514713 0.759 NM_025027
ZNF606
zinc finger protein 606
chr15_+_40698000 0.758 IVD
isovaleryl-CoA dehydrogenase
chr1_-_182361311 0.754 NM_001033044
NM_002065
GLUL

glutamate-ammonia ligase

chrX_+_106045880 0.754 NM_017752
NM_198881
TBC1D8B

TBC1 domain family, member 8B (with GRAM domain)

chr15_+_40698018 0.752 IVD
isovaleryl-CoA dehydrogenase
chr1_+_36690038 0.748 THRAP3
thyroid hormone receptor associated protein 3
chr17_-_42264075 0.746 NM_178542
C17orf65
chromosome 17 open reading frame 65
chr3_-_123339423 0.743 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr12_+_109551041 0.740


chr6_+_52226866 0.740 NM_133367
PAQR8
progestin and adipoQ receptor family member VIII
chr16_+_2039945 0.739 NM_004209
SYNGR3
synaptogyrin 3
chrX_+_134555867 0.733 LINC00086
long intergenic non-protein coding RNA 86
chr5_+_76382458 0.730 LOC728723
uncharacterized LOC728723
chr10_+_75673346 0.729 PLAU
plasminogen activator, urokinase
chr18_+_61442611 0.726 NM_003784
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr9_-_85678042 0.722 NM_152573
RASEF
RAS and EF-hand domain containing
chr20_+_44637539 0.722 NM_004994
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr7_-_150497398 0.720 NM_001101311
NM_001101312
NM_001101314
TMEM176B


transmembrane protein 176B


chr15_+_32322690 0.718 NM_000746
NM_001190455
CHRNA7

cholinergic receptor, nicotinic, alpha 7

chrX_-_47930482 0.717 NM_001037735
ZNF630
zinc finger protein 630
chr7_+_79764087 0.715 NM_002069
GNAI1
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
2.62 7.35e-04 GO:0006355 regulation of transcription, DNA-dependent
2.53 1.50e-03 GO:0051252 regulation of RNA metabolic process
2.46 1.56e-03 GO:2000112 regulation of cellular macromolecule biosynthetic process
2.39 2.56e-03 GO:0010556 regulation of macromolecule biosynthetic process
2.22 9.84e-03 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.22 9.84e-03 GO:0031326 regulation of cellular biosynthetic process
2.20 1.20e-02 GO:0009889 regulation of biosynthetic process
2.24 1.33e-02 GO:0010468 regulation of gene expression
2.16 1.68e-02 GO:0051171 regulation of nitrogen compound metabolic process

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
2.35 1.53e-03 GO:0046914 transition metal ion binding
2.47 1.61e-03 GO:0008270 zinc ion binding
1.91 2.07e-03 GO:0043169 cation binding
1.91 2.18e-03 GO:0043167 ion binding
1.88 4.25e-03 GO:0046872 metal ion binding
65.47 3.27e-02 GO:0016165 lipoxygenase activity
2.09 3.40e-02 GO:0003677 DNA binding