Motif ID: PRRX1,2.p2

Z-value: 2.130


Transcription factors associated with PRRX1,2.p2:

Gene SymbolEntrez IDGene Name
PRRX1 5396 paired related homeobox 1
PRRX2 51450 paired related homeobox 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PRRX1hg19_v1_chr1_+_170633312_170633413-0.699.0e-12Click!
PRRX2hg19_v1_chr9_+_132427919_1324279270.431.3e-04Click!


Activity profile for motif PRRX1,2.p2.

activity profile for motif PRRX1,2.p2


Sorted Z-values histogram for motif PRRX1,2.p2

Sorted Z-values for motif PRRX1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PRRX1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_+_17396285 42.969 NM_001164771
NM_003046
SLC7A2

solute carrier family 7 (cationic amino acid transporter, y+ system), member 2

chr12_-_91576805 37.936 NM_001920
DCN
decorin
chr4_-_39033981 36.224 NM_024943
TMEM156
transmembrane protein 156
chr2_+_210444154 35.115 MAP2
microtubule-associated protein 2
chr2_+_210444364 31.764 NM_002374
NM_031845
NM_031847
MAP2


microtubule-associated protein 2


chr9_-_14086901 31.479 NFIB
nuclear factor I/B
chr21_-_15918635 29.891 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr12_-_91576579 29.725 DCN
decorin
chr2_-_207082626 29.283 NM_001098199
NM_005279
GPR1

G protein-coupled receptor 1

chr2_-_216246961 26.817 FN1
fibronectin 1
chr16_+_82068830 25.383 NM_002153
HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr12_+_101988746 25.377 NM_002465
NM_206819
NM_206820
NM_206821
MYBPC1



myosin binding protein C, slow type



chr16_+_82068910 25.087 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr11_-_18258315 24.659 SAA4
serum amyloid A4, constitutive
chr16_+_82068958 23.363 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr3_-_57234279 23.251 NM_003865
HESX1
HESX homeobox 1
chr1_+_168250277 20.869 NM_005149
TBX19
T-box 19
chr10_+_126630691 20.213 NM_017580
ZRANB1
zinc finger, RAN-binding domain containing 1
chr2_-_216245573 19.640 FN1
fibronectin 1
chr5_+_71502700 19.305 MAP1B
microtubule-associated protein 1B
chr17_-_67138013 19.004 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr6_-_87804773 17.428 NM_000735
NM_001252383
CGA

glycoprotein hormones, alpha polypeptide

chr2_-_216249682 17.061 FN1
fibronectin 1
chr2_-_99279935 16.676 NM_001160154
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr16_+_86612114 16.572 NM_005250
FOXL1
forkhead box L1
chr20_+_5987897 16.361 NM_001127458
CRLS1
cardiolipin synthase 1
chr3_+_69812620 16.029 NM_001184967
MITF
microphthalmia-associated transcription factor
chr3_+_69812961 15.237 NM_006722
MITF
microphthalmia-associated transcription factor
chr11_-_18258383 15.064 NM_006512
SAA4
serum amyloid A4, constitutive
chr9_-_95186559 14.891 NM_005014
OMD
osteomodulin
chr10_+_118305427 14.698 NM_000936
PNLIP
pancreatic lipase
chr7_+_18535351 14.656 NM_001204145
NM_001204146
NM_014707
NM_178423
HDAC9



histone deacetylase 9



chr13_+_99058147 14.492


chr4_-_122085475 14.105 NM_024873
TNIP3
TNFAIP3 interacting protein 3
chr5_-_137475076 14.081 NM_003551
NME5
non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase)
chr7_-_107880492 13.731 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr17_+_38171613 13.605 NM_000759
NM_001178147
NM_172219
NM_172220
CSF3



colony stimulating factor 3 (granulocyte)



chr7_-_41742666 13.546 NM_002192
INHBA
inhibin, beta A
chr12_-_10573041 13.539 NM_002261
NM_007333
KLRC3

killer cell lectin-like receptor subfamily C, member 3

chr12_-_10588543 13.111 NM_002260
KLRC2
KLRC3
killer cell lectin-like receptor subfamily C, member 2
killer cell lectin-like receptor subfamily C, member 3
chr2_-_188419049 13.066 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chrX_+_43515406 12.803 NM_000240
MAOA
monoamine oxidase A
chr18_+_61554938 12.794 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr1_+_196621007 12.699 NM_000186
NM_001014975
CFH

complement factor H

chr2_-_190927321 12.662 NM_005259
MSTN
myostatin
chr17_-_49124128 12.594 NM_001251971
SPAG9
sperm associated antigen 9
chr13_-_34250899 12.454 NM_001243476
STARD13
StAR-related lipid transfer (START) domain containing 13
chr2_-_180427314 12.189 NM_001113398
ZNF385B
zinc finger protein 385B
chr19_-_39368889 11.944 NM_001195833
NM_198445
RINL

Ras and Rab interactor-like

chr2_-_216242916 11.662 FN1
fibronectin 1
chr1_+_92632608 11.646 NM_015237
KIAA1107
KIAA1107
chrX_-_13835012 11.623 GPM6B
glycoprotein M6B
chr2_-_216241321 11.558 FN1
fibronectin 1
chr1_-_114414245 11.466 NM_001193431
NM_012411
NM_015967
PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chr2_-_163099877 11.461 NM_004460
FAP
fibroblast activation protein, alpha
chr3_+_111717585 11.192 NM_001008272
NM_013259
TAGLN3

transgelin 3

chr7_-_7575449 11.183 NM_001037763
COL28A1
collagen, type XXVIII, alpha 1
chr6_+_64356430 11.024 NM_015153
PHF3
PHD finger protein 3
chr21_-_43816123 10.967 NM_024022
NM_032405
TMPRSS3

transmembrane protease, serine 3

chr12_-_15815073 10.844 EPS8
epidermal growth factor receptor pathway substrate 8
chr5_+_35856990 10.642 NM_002185
IL7R
interleukin 7 receptor
chr13_+_76334796 10.511 NM_015842
LMO7
LIM domain 7
chr1_+_151032880 10.510 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chrX_+_43515441 10.439 MAOA
monoamine oxidase A
chr8_-_108510094 10.416 NM_001146
NM_001199859
ANGPT1

angiopoietin 1

chr10_+_17270257 10.315 NM_003380
VIM
vimentin
chr13_-_60325073 10.252


chr1_+_151032866 10.233 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr16_+_53133063 10.191 CHD9
chromodomain helicase DNA binding protein 9
chr1_+_151032683 10.104 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr2_-_145275086 10.033 ZEB2
zinc finger E-box binding homeobox 2
chr5_+_42756919 10.029 NM_001134848
CCDC152
coiled-coil domain containing 152
chr9_-_4666665 9.860 NM_001039395
C9orf68
chromosome 9 open reading frame 68
chr3_+_159557745 9.783 SCHIP1
schwannomin interacting protein 1
chr8_+_107738239 9.689 NM_001198534
NM_001198535
OXR1

oxidation resistance 1

chr12_-_91505215 9.689 LUM
lumican
chr4_+_39063851 9.670 NM_015990
NM_199039
KLHL5

kelch-like 5 (Drosophila)

chr15_+_93443559 9.563 CHD2
chromodomain helicase DNA binding protein 2
chr12_-_15865847 9.492 EPS8
epidermal growth factor receptor pathway substrate 8
chr7_+_91924291 9.445


chr3_+_158787040 9.430 NM_001197113
NM_001197114
NM_001042705
NM_001042706
NM_001197100
IQCJ-SCHIP1

IQCJ


IQCJ-SCHIP1 readthrough

IQ motif containing J


chr10_+_111765725 9.352 NM_019903
ADD3
adducin 3 (gamma)
chr3_+_113616317 9.274 NM_001172105
GRAMD1C
GRAM domain containing 1C
chr2_-_145277568 9.265 ZEB2
zinc finger E-box binding homeobox 2
chr1_+_145524989 9.217 NM_003637
ITGA10
integrin, alpha 10
chr7_+_94297448 9.053 PEG10
paternally expressed 10
chr11_+_87032428 9.000 TMEM135
transmembrane protein 135
chr2_-_122159140 8.936 CLASP1
cytoplasmic linker associated protein 1
chrX_+_43515531 8.923 MAOA
monoamine oxidase A
chr3_+_159557649 8.913 NM_001197109
SCHIP1
schwannomin interacting protein 1
chr1_-_232651227 8.742 NM_020808
SIPA1L2
signal-induced proliferation-associated 1 like 2
chr9_-_86584079 8.740 HNRNPK
heterogeneous nuclear ribonucleoprotein K
chr3_+_69985750 8.720 NM_000248
NM_001184968
NM_198158
NM_198178
MITF



microphthalmia-associated transcription factor



chr1_+_151032906 8.712 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr12_-_105322056 8.700 NM_032148
SLC41A2
solute carrier family 41, member 2
chr3_+_141043054 8.683 NM_001080412
ZBTB38
zinc finger and BTB domain containing 38
chr3_-_141747434 8.668 NM_001178141
NM_001178142
NM_006286
TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr3_-_18480203 8.618 NM_001131010
SATB1
SATB homeobox 1
chr4_-_84035908 8.557 NM_001130715
NM_016619
PLAC8

placenta-specific 8

chr12_-_14967091 8.553 NM_001013698
C12orf69
chromosome 12 open reading frame 69
chr4_+_74606222 8.510 NM_000584
IL8
interleukin 8
chr19_-_44384240 8.484 NM_001033719
ZNF404
zinc finger protein 404
chr4_-_2230957 8.449 NM_181808
POLN
polymerase (DNA directed) nu
chr18_-_21891469 8.444 NM_001242508
OSBPL1A
oxysterol binding protein-like 1A
chr2_-_224467049 8.386 SCG2
secretogranin II
chr17_+_78356710 8.373 RNF213
ring finger protein 213
chr6_+_90276556 8.359 NM_001242814
ANKRD6
ankyrin repeat domain 6
chr4_-_122148620 8.336 NM_001244764
TNIP3
TNFAIP3 interacting protein 3
chr12_-_91573264 8.327 NM_133503
DCN
decorin
chr1_-_242612757 8.322 NM_001195811
NM_001195812
PLD5

phospholipase D family, member 5

chr9_-_14398981 8.295 NM_001190738
NFIB
nuclear factor I/B
chr4_-_84035888 8.278 PLAC8
placenta-specific 8
chr2_+_62934030 8.270 NM_001142614
EHBP1
EH domain binding protein 1
chr17_+_3379295 8.257 NM_000049
ASPA
aspartoacylase
chr4_-_70626429 8.253 NM_014465
SULT1B1
sulfotransferase family, cytosolic, 1B, member 1
chr3_-_187463227 8.249 BCL6
B-cell CLL/lymphoma 6
chr3_-_112359565 8.237 CCDC80
coiled-coil domain containing 80
chr7_+_104752312 8.199 MLL5
myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
chr7_-_108142934 8.133 PNPLA8
patatin-like phospholipase domain containing 8
chr2_-_122247903 8.124 CLASP1
cytoplasmic linker associated protein 1
chr4_-_39523132 8.120 UGDH
UDP-glucose 6-dehydrogenase
chr6_+_31913852 8.039 CFB
complement factor B
chr2_-_234474197 8.028 NM_018218
USP40
ubiquitin specific peptidase 40
chr9_+_127420690 8.018 MIR181A2HG
MIR181A2 host gene (non-protein coding)
chr1_-_100643770 7.967 NM_144620
LRRC39
leucine rich repeat containing 39
chr3_+_130569368 7.966 NM_001199180
NM_001199181
NM_001199182
ATP2C1


ATPase, Ca++ transporting, type 2C, member 1


chr16_-_73092533 7.962 NM_001164766
ZFHX3
zinc finger homeobox 3
chr11_+_20044362 7.934 NAV2
neuron navigator 2
chr11_-_104916041 7.871 NM_001017534
NM_052889
CARD16

caspase recruitment domain family, member 16

chr3_-_185270258 7.844 NM_139248
LIPH
lipase, member H
chr2_+_169659099 7.830 NM_001039724
NM_001171632
NM_052946
NOSTRIN


nitric oxide synthase trafficker


chr3_-_112359547 7.823 CCDC80
coiled-coil domain containing 80
chr3_-_112359251 7.766 CCDC80
coiled-coil domain containing 80
chr2_-_165424993 7.744 GRB14
growth factor receptor-bound protein 14
chr3_-_195310770 7.711 APOD
apolipoprotein D
chr5_-_39394423 7.703 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr12_+_28410132 7.693 NM_018318
CCDC91
coiled-coil domain containing 91
chr3_-_112359277 7.663 CCDC80
coiled-coil domain containing 80
chr2_+_183608329 7.614 DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr13_+_78109808 7.562 NM_001160706
NM_003843
NM_144777
SCEL


sciellin


chr15_+_93443418 7.541 NM_001042572
NM_001271
CHD2

chromodomain helicase DNA binding protein 2

chr5_+_68667280 7.519 NM_133339
RAD17
RAD17 homolog (S. pombe)
chr4_-_76944585 7.484 NM_001565
CXCL10
chemokine (C-X-C motif) ligand 10
chr6_+_31913708 7.483 NM_001710
CFB
complement factor B
chr3_-_112358510 7.475 CCDC80
coiled-coil domain containing 80
chr7_+_90339146 7.427 CDK14
cyclin-dependent kinase 14
chr5_+_147795459 7.396 FBXO38
F-box protein 38
chr7_-_107643330 7.369 NM_002291
LAMB1
laminin, beta 1
chr21_-_27253197 7.354 APP
amyloid beta (A4) precursor protein
chr11_+_5710816 7.319 NM_001199573
NM_006074
TRIM22

tripartite motif containing 22

chr6_+_144612872 7.312 NM_007124
UTRN
utrophin
chr3_+_29322802 7.301 NM_001003792
NM_001003793
NM_001177711
NM_001177712
NM_014483
RBMS3




RNA binding motif, single stranded interacting protein 3




chr3_-_112358758 7.281 CCDC80
coiled-coil domain containing 80
chr9_+_79115548 7.278 NM_001097636
GCNT1
glucosaminyl (N-acetyl) transferase 1, core 2
chr9_-_86082656 7.273 NM_001244960
FRMD3
FERM domain containing 3
chr1_+_167298280 7.261 NM_001198783
POU2F1
POU class 2 homeobox 1
chr5_+_65372744 7.248 ERBB2IP
erbb2 interacting protein
chr11_+_5710926 7.205 TRIM22
tripartite motif containing 22
chr8_-_62602285 7.177 NM_001164750
NM_001164751
NM_001164752
NM_001164753
NM_020164
NM_032467
NM_032468
ASPH






aspartate beta-hydroxylase






chr5_+_71403040 7.173 NM_005909
MAP1B
microtubule-associated protein 1B
chr2_+_152214105 7.099 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr3_-_187452669 7.078 NM_001134738
BCL6
B-cell CLL/lymphoma 6
chr9_+_125033126 7.048 NM_199177
MRRF
mitochondrial ribosome recycling factor
chr6_+_34206567 6.993 NM_145905
HMGA1
high mobility group AT-hook 1
chr12_-_102512277 6.991 NM_024057
NUP37
nucleoporin 37kDa
chr1_+_167298382 6.991 POU2F1
POU class 2 homeobox 1
chr20_+_9288446 6.977 NM_000933
PLCB4
phospholipase C, beta 4
chr4_-_110723334 6.904 NM_000204
CFI
complement factor I
chr10_+_118187381 6.900 NM_001011709
PNLIPRP3
pancreatic lipase-related protein 3
chr3_-_112359443 6.864 CCDC80
coiled-coil domain containing 80
chr11_-_58343308 6.863 NM_004811
LPXN
leupaxin
chr7_-_7758237 6.840 NM_002947
RPA3
replication protein A3, 14kDa
chr13_+_50025687 6.788 NM_001160308
SETDB2
SET domain, bifurcated 2
chr1_+_59775749 6.771 NM_001244714
FGGY
FGGY carbohydrate kinase domain containing
chr1_+_244216506 6.742 NM_006352
ZNF238
zinc finger protein 238
chr7_-_92777657 6.715 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr1_+_104097321 6.699 NM_020978
AMY2B
amylase, alpha 2B (pancreatic)
chr4_+_41614725 6.668 LIMCH1
LIM and calponin homology domains 1
chr2_-_55199894 6.664


chr3_+_136649316 6.647 NM_001190796
NCK1
NCK adaptor protein 1
chr4_-_110723127 6.633 CFI
complement factor I
chr4_+_71384289 6.630 NM_212557
AMTN
amelotin
chr11_+_10476665 6.626 NM_001025389
AMPD3
adenosine monophosphate deaminase 3
chr17_-_67240955 6.604 NM_080282
ABCA10
ATP-binding cassette, sub-family A (ABC1), member 10
chr6_-_75965845 6.595 TMEM30A
transmembrane protein 30A
chr9_+_97521930 6.591 NM_001193329
C9orf3
chromosome 9 open reading frame 3
chrM_+_10704 6.584


chr3_+_69915374 6.495 NM_198177
MITF
microphthalmia-associated transcription factor
chr16_-_29910340 6.492 NM_001114099
NM_001114100
NM_001243332
NM_001243333
NM_012410
NM_201575
SEZ6L2





seizure related 6 homolog (mouse)-like 2





chr3_-_123339178 6.487 MYLK
myosin light chain kinase
chr15_+_49715374 6.451 NM_002009
FGF7
fibroblast growth factor 7
chr6_-_167275657 6.451 NM_001006932
RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr10_-_21186530 6.449 NM_006393
NEBL
nebulette
chr4_+_77356252 6.443 NM_020859
SHROOM3
shroom family member 3
chr20_+_9198036 6.416 NM_182797
PLCB4
phospholipase C, beta 4
chrX_-_107018889 6.413 TSC22D3
TSC22 domain family, member 3
chr12_+_54410893 6.346 HOXC5
HOXC6
homeobox C5
homeobox C6
chr14_-_92198383 6.320 NM_024764
CATSPERB
cation channel, sperm-associated, beta
chr10_-_5045967 6.298 NM_001135241
AKR1C2
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
chr6_+_31913763 6.280 CFB
complement factor B

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.35 2.62e-05 GO:0007275 multicellular organismal development
1.33 3.07e-05 GO:0032502 developmental process
1.21 4.10e-05 GO:0050794 regulation of cellular process
1.18 1.32e-04 GO:0065007 biological regulation
1.18 2.93e-04 GO:0050789 regulation of biological process
1.34 4.21e-04 GO:0048856 anatomical structure development
1.53 5.43e-04 GO:0009653 anatomical structure morphogenesis
1.38 2.22e-03 GO:0048519 negative regulation of biological process
1.43 2.74e-03 GO:0048583 regulation of response to stimulus
1.33 2.78e-03 GO:0048731 system development
1.38 5.84e-03 GO:0048523 negative regulation of cellular process
1.41 6.15e-03 GO:0048513 organ development
9.71 1.81e-02 GO:0009812 flavonoid metabolic process
1.49 2.27e-02 GO:0002376 immune system process
1.45 3.38e-02 GO:0009966 regulation of signal transduction

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
1.18 8.19e-05 GO:0005515 protein binding
2.14 4.87e-04 GO:0003779 actin binding
2.33 9.48e-04 GO:0046982 protein heterodimerization activity
1.60 1.18e-03 GO:0030234 enzyme regulator activity
1.81 1.53e-03 GO:0008092 cytoskeletal protein binding
1.08 1.62e-02 GO:0005488 binding
1.49 3.05e-02 GO:0001071 nucleic acid binding transcription factor activity
1.49 3.05e-02 GO:0003700 sequence-specific DNA binding transcription factor activity
1.56 3.68e-02 GO:0019899 enzyme binding