Motif ID: POU2F1..3.p2

Z-value: 1.922


Transcription factors associated with POU2F1..3.p2:

Gene SymbolEntrez IDGene Name
POU2F1 5451 POU class 2 homeobox 1
POU2F2 5452 POU class 2 homeobox 2
POU2F3 25833 POU class 2 homeobox 3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
POU2F3hg19_v1_chr11_+_120107348_1201073480.472.1e-05Click!
POU2F1hg19_v1_chr1_+_167298382_1672984970.171.4e-01Click!
POU2F2hg19_v1_chr19_-_42636559_426366240.104.2e-01Click!


Activity profile for motif POU2F1..3.p2.

activity profile for motif POU2F1..3.p2


Sorted Z-values histogram for motif POU2F1..3.p2

Sorted Z-values for motif POU2F1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU2F1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_201979689 31.024 NM_001114309
NM_004433
ELF3

E74-like factor 3 (ets domain transcription factor, epithelial-specific )

chr14_-_107211131 29.377 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr1_+_201979747 28.674 ELF3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr14_-_107218786 28.191 IGHA1
IGHG1
IGHM
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr10_-_64578926 25.667 NM_001136178
EGR2
early growth response 2
chr10_-_64576123 19.593 NM_000399
NM_001136177
NM_001136179
EGR2


early growth response 2


chr10_-_64576074 18.180 EGR2
early growth response 2
chrX_-_106960028 16.518 TSC22D3
TSC22 domain family, member 3
chr6_-_27860927 15.203 NM_003514
HIST1H2AM
histone cluster 1, H2am
chrX_-_106960268 14.868 NM_004089
TSC22D3
TSC22 domain family, member 3
chr11_+_34642651 13.862 EHF
ets homologous factor
chr6_-_11232883 13.504 NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr6_-_11232900 13.161 NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr11_+_34642587 13.147 NM_001206615
NM_012153
EHF

ets homologous factor

chr1_+_68151092 13.011 GADD45A
growth arrest and DNA-damage-inducible, alpha
chr6_-_11232901 12.973 NM_006403
NM_182966
NEDD9

neural precursor cell expressed, developmentally down-regulated 9

chr1_+_68150858 12.905 NM_001199741
NM_001199742
NM_001924
GADD45A


growth arrest and DNA-damage-inducible, alpha


chr15_-_41166336 11.965 NM_133639
RHOV
ras homolog gene family, member V
chr2_-_207082626 11.802 NM_001098199
NM_005279
GPR1

G protein-coupled receptor 1

chr5_+_145317297 11.011 SH3RF2
SH3 domain containing ring finger 2
chr2_-_239197091 10.138 NM_022817
PER2
period homolog 2 (Drosophila)
chr7_+_37779995 9.534 NM_181791
GPR141
G protein-coupled receptor 141
chr10_+_123922940 9.141 TACC2
transforming, acidic coiled-coil containing protein 2
chr6_+_26124372 8.865 NM_003512
HIST1H2AC
histone cluster 1, H2ac
chr6_+_27100784 8.742 NM_021064
HIST1H2AG
histone cluster 1, H2ag
chr10_+_123923104 8.540 NM_006997
NM_206860
TACC2

transforming, acidic coiled-coil containing protein 2

chr1_+_61547625 7.995 NM_001134673
NM_005595
NFIA

nuclear factor I/A

chr17_-_37381920 7.989 NM_198993
STAC2
SH3 and cysteine rich domain 2
chr17_-_7832752 7.876 NM_004732
KCNAB3
potassium voltage-gated channel, shaker-related subfamily, beta member 3
chr5_-_2751768 7.735 NM_001134222
NM_033267
IRX2

iroquois homeobox 2

chr19_-_18392048 7.543 JUND
jun D proto-oncogene
chr11_+_537521 7.497 NM_198075
LRRC56
leucine rich repeat containing 56
chr7_+_100183926 7.448 NM_033506
FBXO24
F-box protein 24
chr4_-_47840058 7.401 NM_006587
CORIN
corin, serine peptidase
chr6_-_27782517 7.399 NM_021066
HIST1H2AJ
histone cluster 1, H2aj
chr1_-_228645517 7.239 NM_033445
HIST3H2A
histone cluster 3, H2a
chr12_+_53442732 7.047 NM_015319
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr20_+_33292117 7.032 NM_021202
TP53INP2
tumor protein p53 inducible nuclear protein 2
chr17_-_19651586 6.969 NM_000691
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr6_-_26216871 6.767 NM_003518
HIST1H2BG
NCALD
histone cluster 1, H2bg
neurocalcin delta
chr19_-_18392436 6.737 JUND
jun D proto-oncogene
chr6_-_35656610 6.710 FKBP5
FK506 binding protein 5
chr3_+_132036210 6.689 NM_001099
NM_001134194
ACPP

acid phosphatase, prostate

chr1_+_18807423 6.517 NM_152375
KLHDC7A
kelch domain containing 7A
chr6_-_35656677 6.462 NM_001145776
NM_001145777
NM_004117
FKBP5


FK506 binding protein 5


chrX_-_15402469 6.432 NM_004469
FIGF
c-fos induced growth factor (vascular endothelial growth factor D)
chr7_-_100183722 6.352 LRCH4
leucine-rich repeats and calponin homology (CH) domain containing 4
chr19_-_18392413 6.303 NM_005354
JUND
jun D proto-oncogene
chr13_+_52027435 6.216


chr3_-_87040268 6.075 VGLL3
vestigial like 3 (Drosophila)
chr6_+_26183957 6.035 NM_003523
HIST1H2BE
histone cluster 1, H2be
chr2_+_152214105 6.023 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr16_-_74808699 5.994 NM_024306
FA2H
fatty acid 2-hydroxylase
chr16_+_85645014 5.984 NM_001134473
KIAA0182
KIAA0182
chr16_-_74808474 5.937 FA2H
fatty acid 2-hydroxylase
chr12_-_11091805 5.804 NM_023922
TAS2R14
taste receptor, type 2, member 14
chr9_+_109686436 5.800 ZNF462
zinc finger protein 462
chr17_-_8063946 5.774 VAMP2
vesicle-associated membrane protein 2 (synaptobrevin 2)
chr12_+_53442972 5.740 TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr16_-_30107492 5.732 NM_031477
NM_001145524
YPEL3

yippee-like 3 (Drosophila)

chr5_+_2752261 5.729 NM_178569
C5orf38
chromosome 5 open reading frame 38
chr3_-_87040246 5.620 NM_016206
VGLL3
vestigial like 3 (Drosophila)
chr11_+_112047088 5.618 NM_001037290
BCO2
beta-carotene oxygenase 2
chr9_+_136325086 5.521 NM_001135775
NM_001242369
NM_001242370
NM_017586
C9orf7



chromosome 9 open reading frame 7



chr6_+_27114860 5.349 NM_080596
HIST1H2AH
histone cluster 1, H2ah
chr3_+_132036276 5.327 ACPP
acid phosphatase, prostate
chr18_+_44526786 5.325 NM_031303
KATNAL2
katanin p60 subunit A-like 2
chr2_+_211458078 4.790 NM_001122634
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr1_+_228645807 4.759 NM_175055
HIST3H2BB
histone cluster 3, H2bb
chr7_+_18535351 4.677 NM_001204145
NM_001204146
NM_014707
NM_178423
HDAC9



histone deacetylase 9



chr14_-_107199126 4.640 IGHG3
immunoglobulin heavy constant gamma 3 (G3m marker)
chr1_-_149859465 4.611 NM_175065
HIST2H2AB
HIST2H2BE
histone cluster 2, H2ab
histone cluster 2, H2be
chr17_+_72983723 4.588 NM_014603
CDR2L
cerebellar degeneration-related protein 2-like
chr6_+_10585978 4.514 NM_145655
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr16_+_30107742 4.355


chr19_-_44123732 4.286 ZNF428
zinc finger protein 428
chr13_+_97794050 4.285 MBNL2
muscleblind-like 2 (Drosophila)
chr6_-_27100528 4.207 NM_021058
HIST1H2BJ
histone cluster 1, H2bj
chr19_-_50143350 4.196 NM_006270
RRAS
related RAS viral (r-ras) oncogene homolog
chr6_+_43139201 4.125 SRF
serum response factor (c-fos serum response element-binding transcription factor)
chr19_+_56111600 4.123 NM_153219
ZNF524
zinc finger protein 524
chr12_+_14518608 3.958 NM_018179
ATF7IP
activating transcription factor 7 interacting protein
chr6_+_27833033 3.958 NM_003511
HIST1H2AI
HIST1H2AL
histone cluster 1, H2ai
histone cluster 1, H2al
chr10_-_98031154 3.837 NM_001114094
NM_013314
BLNK

B-cell linker

chr2_-_224467142 3.774 NM_003469
SCG2
secretogranin II
chr11_+_27062508 3.702 NM_003986
BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr11_+_112046207 3.677 NM_031938
BCO2
beta-carotene oxygenase 2
chr17_+_43213013 3.620 NM_001135705
NM_001135706
NM_001135707
NM_024722
ACBD4



acyl-CoA binding domain containing 4



chr14_-_106791054 3.605 IGHV4-31
IGHV3-30
IGHA1
IGHD
IGHG1
IGHG2
IGHG3
IGHM
SCFV
immunoglobulin heavy variable 4-31
immunoglobulin heavy variable 3-30
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 2 (G2m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
single-chain Fv fragment
chr7_-_100183753 3.552 NM_002319
LRCH4
leucine-rich repeats and calponin homology (CH) domain containing 4
chr19_-_44124013 3.531 NM_182498
ZNF428
zinc finger protein 428
chr5_+_60628085 3.464 NM_020928
ZSWIM6
zinc finger, SWIM-type containing 6
chr17_+_20059192 3.444 NM_001033554
NM_001033555
NM_001243438
SPECC1


sperm antigen with calponin homology and coiled-coil domains 1


chr1_-_186649421 3.436 NM_000963
PTGS2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
chr1_+_61547388 3.431 NM_001145512
NFIA
nuclear factor I/A
chrX_-_117119282 3.380 NM_001168299
KLHL13
kelch-like 13 (Drosophila)
chr8_-_25282555 3.378 NM_000825
NM_001083111
GNRH1

gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)

chr4_-_186733372 3.351 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr6_-_26033795 3.351 NM_003513
HIST1H2AB
histone cluster 1, H2ab
chr19_-_47164289 3.283 NM_145056
DACT3
dapper, antagonist of beta-catenin, homolog 3 (Xenopus laevis)
chr10_-_97321094 3.232 NM_015385
NM_024991
SORBS1

sorbin and SH3 domain containing 1

chr2_+_97426571 3.223 NM_020184
CNNM4
cyclin M4
chr6_+_26217145 3.154 NM_021052
HIST1H2AE
histone cluster 1, H2ae
chr9_+_129677046 3.128 NM_001190729
NM_001190730
NM_014636
RALGPS1


Ral GEF with PH domain and SH3 binding motif 1


chr4_-_40517913 3.108 NM_019027
RBM47
RNA binding motif protein 47
chr6_+_26251826 3.063 NM_003524
HIST1H2BH
histone cluster 1, H2bh
chr7_+_141490016 3.004 NM_018980
TAS2R5
taste receptor, type 2, member 5
chr12_-_57443858 2.934 NM_005379
MYO1A
myosin IA
chr1_+_6052758 2.841 KCNAB2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
chrX_-_55020510 2.795 NM_002625
PFKFB1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr14_-_24553817 2.794 NM_006177
NRL
neural retina leucine zipper
chr6_+_148663728 2.760 NM_015278
SASH1
SAM and SH3 domain containing 1
chr3_-_48594209 2.712 NM_004567
PFKFB4
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
chr7_+_90338711 2.695 NM_012395
CDK14
cyclin-dependent kinase 14
chr6_+_148663953 2.660 SASH1
SAM and SH3 domain containing 1
chr1_+_206730456 2.578 NM_182665
RASSF5
Ras association (RalGDS/AF-6) domain family member 5
chr4_-_18023358 2.568 NM_001166139
NM_153686
LCORL

ligand dependent nuclear receptor corepressor-like

chr20_+_34556528 2.567 NM_001207076
NM_080834
C20orf152

chromosome 20 open reading frame 152

chr19_+_17337012 2.530 NM_024578
OCEL1
occludin/ELL domain containing 1
chr12_-_56359794 2.508 NM_001200053
NM_001200054
PMEL

premelanosome protein

chr1_+_6052699 2.443 KCNAB2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
chr12_-_6484557 2.439 SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr22_-_24096551 2.405 NM_013378
VPREB3
pre-B lymphocyte 3
chrX_-_80457440 2.399 NM_030763
HMGN5
high mobility group nucleosome binding domain 5
chr6_+_27861202 2.392 NM_003527
HIST1H2BO
histone cluster 1, H2bo
chr6_+_43139190 2.370 SRF
serum response factor (c-fos serum response element-binding transcription factor)
chr12_-_6484389 2.366 NM_001159576
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr22_+_44319685 2.359 PNPLA3
patatin-like phospholipase domain containing 3
chr1_-_149858114 2.343 NM_003528
HIST2H2BE
histone cluster 2, H2be
chr20_-_40246991 2.315 NM_032221
CHD6
chromodomain helicase DNA binding protein 6
chr1_+_206730497 2.271 RASSF5
Ras association (RalGDS/AF-6) domain family member 5
chr3_-_172241060 2.257 NM_001190943
NM_001190942
NM_003810
TNFSF10


tumor necrosis factor (ligand) superfamily, member 10


chr22_-_36556781 2.256 NM_145640
APOL3
apolipoprotein L, 3
chr19_+_3572958 2.223 HMG20B
high mobility group 20B
chr12_-_122240827 2.180


chrX_-_131547536 2.177 NM_001170701
NM_001170702
NM_001170703
MBNL3


muscleblind-like 3 (Drosophila)


chr18_-_52988916 2.160 NM_001243234
NM_001243235
TCF4

transcription factor 4

chr22_+_44319674 2.126 PNPLA3
patatin-like phospholipase domain containing 3
chr19_-_19144304 2.050 SUGP2
SURP and G patch domain containing 2
chr22_+_44319618 2.047 NM_025225
PNPLA3
patatin-like phospholipase domain containing 3
chr2_-_113594325 2.022 NM_000576
IL1B
interleukin 1, beta
chr10_-_62332666 2.011 NM_001204404
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr7_-_27153490 1.971 HOXA3
homeobox A3
chr6_+_27782793 1.970 NM_003521
HIST1H2BM
histone cluster 1, H2bm
chr19_-_19144262 1.923 SUGP2
SURP and G patch domain containing 2
chr8_+_42396297 1.870 NM_001135676
C8orf40
chromosome 8 open reading frame 40
chr11_+_120107348 1.851 NM_001244682
POU2F3
POU class 2 homeobox 3
chr6_+_43138919 1.850 NM_003131
SRF
serum response factor (c-fos serum response element-binding transcription factor)
chr5_-_39219578 1.844 NM_001465
NM_199335
FYB

FYN binding protein

chr19_-_893184 1.843 MED16
mediator complex subunit 16
chr5_+_173472692 1.827 NM_015980
HMP19
HMP19 protein
chr19_+_1269244 1.771 NM_001280
CIRBP
cold inducible RNA binding protein
chr15_-_89456592 1.771 NM_001114614
NM_005928
MFGE8

milk fat globule-EGF factor 8 protein

chr3_+_111758464 1.766 NM_001042575
TMPRSS7
transmembrane protease, serine 7
chr17_+_80317122 1.761 NM_207459
TEX19
testis expressed 19
chr7_+_94539209 1.749 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory subunit 9A


chr3_-_121379701 1.746 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr15_-_89456549 1.739 MFGE8
milk fat globule-EGF factor 8 protein
chr19_-_19144326 1.725 NM_001017392
NM_014884
SUGP2

SURP and G patch domain containing 2

chr17_+_9745847 1.708 GLP2R
glucagon-like peptide 2 receptor
chr18_+_76740274 1.693 NM_171999
SALL3
sal-like 3 (Drosophila)
chr6_+_139094656 1.679 NM_015439
CCDC28A
coiled-coil domain containing 28A
chr3_-_123603144 1.667 NM_053025
NM_053026
NM_053027
NM_053028
MYLK



myosin light chain kinase



chr5_-_176935877 1.641 DOK3
docking protein 3
chr19_+_58907456 1.636 NM_001195135
LOC646862
uncharacterized LOC646862
chrX_-_65859107 1.618 NM_001199687
EDA2R
ectodysplasin A2 receptor
chr2_+_202047620 1.612 NM_001206524
NM_001206542
NM_001230
NM_032974
NM_032976
NM_032977
CASP10





caspase 10, apoptosis-related cysteine peptidase





chr14_-_106994001 1.598 IGHV3-48
IGH@
IGHA1
IGHM
immunoglobulin heavy variable 3-48
immunoglobulin heavy locus
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant mu
chr19_+_3572903 1.594 NM_006339
HMG20B
high mobility group 20B
chr17_-_56494930 1.587 NM_017763
RNF43
ring finger protein 43
chr5_-_175964824 1.582 RNF44
ring finger protein 44
chr19_+_3572950 1.570 HMG20B
high mobility group 20B
chr1_-_149814264 1.542 NM_001040874
NM_003516
HIST2H2AA4
HIST2H2AA3
histone cluster 2, H2aa4
histone cluster 2, H2aa3
chr2_-_172750724 1.534 NM_003705
SLC25A12
solute carrier family 25 (mitochondrial carrier, Aralar), member 12
chr19_-_40931880 1.525 NM_013376
SERTAD1
SERTA domain containing 1
chr15_-_89089792 1.500 NM_001144074
NM_017996
DET1

de-etiolated homolog 1 (Arabidopsis)

chr16_-_88752788 1.497 SNAI3
snail homolog 3 (Drosophila)
chr19_-_893215 1.496 NM_005481
MED16
mediator complex subunit 16
chr19_-_19281062 1.488 MEF2B
myocyte enhancer factor 2B
chr19_-_19281090 1.478 NM_001145785
MEF2B
myocyte enhancer factor 2B
chrX_-_102347950 1.449 NM_022052
NXF3
nuclear RNA export factor 3
chr6_-_26124130 1.445 NM_003526
HIST1H2BG
HIST1H2BC
histone cluster 1, H2bg
histone cluster 1, H2bc
chr12_-_57328044 1.436 NM_148897
SDR9C7
short chain dehydrogenase/reductase family 9C, member 7
chr6_+_26158332 1.423 NM_021063
NM_138720
HIST1H2BD

histone cluster 1, H2bd

chr17_-_67138013 1.421 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr6_+_27215479 1.419 NM_005865
PRSS16
protease, serine, 16 (thymus)
chr1_+_33722158 1.395 NM_152493
ZNF362
zinc finger protein 362
chr3_-_149086884 1.390 TM4SF1
transmembrane 4 L six family member 1
chrM_+_5769 1.374


chr1_+_149822627 1.367 NM_001040874
NM_003516
HIST2H2AA4
HIST2H2AA3
histone cluster 2, H2aa4
histone cluster 2, H2aa3
chr10_-_123356158 1.362 NM_001144915
FGFR2
fibroblast growth factor receptor 2
chr16_-_90096308 1.360 NM_001214
C16orf3
chromosome 16 open reading frame 3
chr7_+_112120907 1.355 NM_001134468
NM_182597
C7orf53

chromosome 7 open reading frame 53

chr2_+_207804277 1.351 NM_173077
CPO
carboxypeptidase O
chr20_-_49547451 1.347 NM_015339
NM_181442
ADNP

activity-dependent neuroprotector homeobox

chr22_+_24033047 1.344 NM_153615
RGL4
ral guanine nucleotide dissociation stimulator-like 4
chr16_+_53164784 1.320 CHD9
chromodomain helicase DNA binding protein 9
chr4_-_152682092 1.311 NM_004564
PET112
PET112 homolog (yeast)
chr2_+_170683900 1.304 NM_172070
UBR3
ubiquitin protein ligase E3 component n-recognin 3 (putative)
chr10_+_32856650 1.294 NM_024688
C10orf68
chromosome 10 open reading frame 68

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
16.79 6.73e-13 GO:0006334 nucleosome assembly
12.87 1.31e-12 GO:0006333 chromatin assembly or disassembly
15.92 1.62e-12 GO:0031497 chromatin assembly
15.14 3.71e-12 GO:0034728 nucleosome organization
14.57 6.97e-12 GO:0065004 protein-DNA complex assembly
13.79 1.71e-11 GO:0071824 protein-DNA complex subunit organization
12.16 1.29e-10 GO:0006323 DNA packaging
10.44 1.44e-09 GO:0071103 DNA conformation change
4.73 1.69e-06 GO:0006325 chromatin organization
5.16 6.75e-06 GO:0034622 cellular macromolecular complex assembly
3.64 1.57e-04 GO:0051276 chromosome organization
3.87 5.06e-04 GO:0034621 cellular macromolecular complex subunit organization
3.15 9.23e-04 GO:0071844 cellular component assembly at cellular level
3.03 9.16e-03 GO:0009719 response to endogenous stimulus
3.15 9.37e-03 GO:0009725 response to hormone stimulus
2.90 1.68e-02 GO:0065003 macromolecular complex assembly

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
25.74 7.22e-17 GO:0000786 nucleosome
9.24 1.77e-13 GO:0000785 chromatin
16.26 1.97e-13 GO:0032993 protein-DNA complex
4.43 7.05e-08 GO:0005694 chromosome
4.84 7.47e-08 GO:0044427 chromosomal part
1.52 2.36e-04 GO:0005634 nucleus

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
14.48 4.33e-04 GO:0003823 antigen binding
1.91 1.17e-03 GO:0003677 DNA binding
1.56 3.93e-02 GO:0003676 nucleic acid binding