Motif ID: POU1F1.p2

Z-value: 0.890


Transcription factors associated with POU1F1.p2:

Gene SymbolEntrez IDGene Name
POU1F1 5449 POU class 1 homeobox 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
POU1F1hg19_v1_chr3_-_87325611_873257360.404.5e-04Click!


Activity profile for motif POU1F1.p2.

activity profile for motif POU1F1.p2


Sorted Z-values histogram for motif POU1F1.p2

Sorted Z-values for motif POU1F1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU1F1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_+_69061599 5.849 NM_138768
MYEOV
myeloma overexpressed (in a subset of t(11;14) positive multiple myelomas)
chr3_+_151488214 5.149 LOC201651
arylacetamide deacetylase (esterase) pseudogene
chr16_+_82068910 3.151 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr16_+_82068830 3.057 NM_002153
HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr3_-_61728810 2.953


chr2_+_102953716 2.379 NM_003856
IL1RL1
interleukin 1 receptor-like 1
chr5_-_75919051 2.250 NM_004101
F2RL2
coagulation factor II (thrombin) receptor-like 2
chr6_+_154897419 2.166


chr13_-_20110884 2.147 NM_001141968
NM_130785
NM_199254
TPTE2


transmembrane phosphoinositide 3-phosphatase and tensin homolog 2


chr18_+_61554938 2.109 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr1_+_196857143 2.104 NM_001201550
NM_001201551
NM_006684
CFHR4


complement factor H-related 4


chr9_+_21440452 2.084 NM_024013
IFNA1
interferon, alpha 1
chr12_+_55248298 2.030 NM_058173
MUCL1
mucin-like 1
chr12_-_14849427 2.021 NM_004963
GUCY2C
guanylate cyclase 2C (heat stable enterotoxin receptor)
chr2_-_224467142 1.918 NM_003469
SCG2
secretogranin II
chr1_+_248128534 1.887 NM_001004491
OR2AK2
olfactory receptor, family 2, subfamily AK, member 2
chr11_+_30252562 1.887 NM_000510
NM_001018080
FSHB

follicle stimulating hormone, beta polypeptide

chr3_+_97158453 1.880 NM_173655
EPHA6
EPH receptor A6
chr9_-_21368005 1.875 NM_006900
IFNA1
IFNA13
interferon, alpha 1
interferon, alpha 13
chr3_+_151591428 1.809 NM_033050
SUCNR1
succinate receptor 1
chr6_+_153019029 1.786 NM_025107
MYCT1
myc target 1
chr21_-_15918635 1.730 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr7_+_37779995 1.730 NM_181791
GPR141
G protein-coupled receptor 141
chr4_+_95376396 1.708 PDLIM5
PDZ and LIM domain 5
chr1_+_172389827 1.679 NM_139240
C1orf105
chromosome 1 open reading frame 105
chr19_+_42381189 1.584 NM_001783
NM_021601
CD79A

CD79a molecule, immunoglobulin-associated alpha

chr2_+_36923832 1.550 NM_001177969
NM_001177970
NM_001177971
NM_001177972
NM_053276
VIT




vitrin




chr11_-_101787252 1.547 NM_178127
ANGPTL5
angiopoietin-like 5
chrX_-_131261871 1.504 NM_194277
FRMD7
FERM domain containing 7
chr11_-_128457452 1.454 NM_001143820
ETS1
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
chr12_+_113344811 1.357 OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr5_-_93077196 1.346 NM_153216
POU5F2
POU domain class 5, transcription factor 2
chr7_+_137761177 1.342 NM_001190906
NM_001190907
NM_005989
AKR1D1


aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)


chr4_+_155484131 1.313 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr1_-_173020011 1.304 NM_005092
TNFSF18
tumor necrosis factor (ligand) superfamily, member 18
chr4_-_70518964 1.291 NM_001252274
NM_001252275
NM_006798
UGT2A1


UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus


chr2_-_224467095 1.289 SCG2
secretogranin II
chr17_-_39222126 1.285 NM_033184
KRTAP2-4
keratin associated protein 2-4
chr4_+_71337674 1.266 NM_001145007
MUC7
mucin 7, secreted
chr4_-_39033981 1.259 NM_024943
TMEM156
transmembrane protein 156
chr5_-_41213513 1.230 NM_000065
C6
complement component 6
chr12_+_72332625 1.224 NM_173353
TPH2
tryptophan hydroxylase 2
chr12_+_78225068 1.210 NM_014903
NAV3
neuron navigator 3
chr3_+_108021331 1.207 NM_007072
HHLA2
HERV-H LTR-associating 2
chr8_-_86253863 1.203 NM_001164830
CA1
carbonic anhydrase I
chr12_+_100867739 1.200 NR1H4
nuclear receptor subfamily 1, group H, member 4
chr3_+_132316080 1.198 NM_016557
CCRL1
chemokine (C-C motif) receptor-like 1
chr4_+_71337833 1.183 NM_152291
MUC7
mucin 7, secreted
chr2_-_77749335 1.181 NM_001134745
NM_024993
LRRTM4

leucine rich repeat transmembrane neuronal 4

chr13_+_46276445 1.169 NM_152719
SPERT
spermatid associated
chr17_+_74463629 1.152 NM_001088
AANAT
aralkylamine N-acetyltransferase
chr9_+_21409132 1.151 NM_002170
IFNA8
interferon, alpha 8
chr7_+_142919129 1.150 NM_176882
TAS2R40
taste receptor, type 2, member 40
chr13_-_46756291 1.150 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr6_-_33041266 1.142 NM_033554
HLA-DPA1
major histocompatibility complex, class II, DP alpha 1
chr6_+_27292539 1.138 NM_032030
FKSG83
FKSG83
chr16_-_21314371 1.136 NM_001014444
NM_001888
CRYM

crystallin, mu

chr18_-_64271215 1.131 NM_021153
CDH19
cadherin 19, type 2
chr19_+_45116921 1.127 NM_001205280
IGSF23
immunoglobulin superfamily, member 23
chr6_-_22297729 1.102 NM_000948
PRL
prolactin
chr5_+_92918924 1.097 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr12_-_50790391 1.096 NM_001145475
FAM186A
family with sequence similarity 186, member A
chrX_+_36065052 1.095 NM_173695
CXorf59
chromosome X open reading frame 59
chr16_+_67381252 1.094 NM_001161575
LRRC36
leucine rich repeat containing 36
chr11_+_18194383 1.085 NM_054032
MRGPRX4
MAS-related GPR, member X4
chr3_+_12392993 1.084 NM_015869
PPARG
peroxisome proliferator-activated receptor gamma
chr1_+_17531619 1.076 NM_013358
PADI1
peptidyl arginine deiminase, type I
chr3_-_87325611 1.071 NM_000306
NM_001122757
POU1F1

POU class 1 homeobox 1

chr15_+_66694216 1.068 MAP2K1
mitogen-activated protein kinase kinase 1
chr6_+_105404922 1.065 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr7_-_45018559 1.057 MYO1G
myosin IG
chr12_+_113344738 1.055 NM_001032409
NM_002534
NM_016816
OAS1


2'-5'-oligoadenylate synthetase 1, 40/46kDa


chr14_-_101036130 1.052 NM_020836
BEGAIN
brain-enriched guanylate kinase-associated homolog (rat)
chr1_-_20445991 1.048 NM_012400
PLA2G2D
phospholipase A2, group IID
chr4_+_74270832 1.047 ALB
albumin
chr1_-_93399531 1.044


chr4_+_119948322 1.041 SYNPO2
synaptopodin 2
chr12_+_10034087 1.038 NM_001190765
KLRF2
killer cell lectin-like receptor subfamily F, member 2
chr10_+_101088794 1.034 NM_020348
CNNM1
cyclin M1
chr2_+_102770401 1.033 NM_000877
IL1R1
interleukin 1 receptor, type I
chr7_-_45018677 1.032 NM_033054
MYO1G
myosin IG
chr1_-_157789832 1.026 NM_001159397
NM_001159398
NM_052938
FCRL1


Fc receptor-like 1


chr11_-_102745666 1.023 NM_002426
MMP12
matrix metallopeptidase 12 (macrophage elastase)
chr8_+_39771327 1.020 NM_002164
IDO1
indoleamine 2,3-dioxygenase 1
chrX_+_66788682 1.006 NM_001011645
AR
androgen receptor
chr16_+_82068958 1.002 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chrX_-_127186339 0.999 NM_138289
ACTRT1
actin-related protein T1
chr3_+_132318980 0.995 NM_178445
CCRL1
chemokine (C-C motif) receptor-like 1
chrX_-_49460568 0.992 NM_003785
PAGE1
P antigen family, member 1 (prostate associated)
chr12_+_92817734 0.990 NM_001025233
CLLU1
chronic lymphocytic leukemia up-regulated 1
chrX_+_7810302 0.988 NM_013452
VCX
variable charge, X-linked
chrX_+_71364033 0.986 NM_207422
FLJ44635
TPT1-like protein
chr11_-_48373998 0.969 NM_001005513
OR4C45
olfactory receptor, family 4, subfamily C, member 45
chr3_-_27498244 0.969 NM_003615
SLC4A7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
chr12_-_117747214 0.962 NM_001204214
NOS1
nitric oxide synthase 1 (neuronal)
chr1_+_84874033 0.957 NM_058248
DNASE2B
deoxyribonuclease II beta
chr10_+_15085894 0.955 NM_001039702
NM_018324
OLAH

oleoyl-ACP hydrolase

chr6_+_72922513 0.950 NM_001168407
NM_001168408
RIMS1

regulating synaptic membrane exocytosis 1

chr12_-_10978867 0.950 NM_023921
TAS2R10
taste receptor, type 2, member 10
chr19_-_48389514 0.948 SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr3_-_170744458 0.945 SLC2A2
solute carrier family 2 (facilitated glucose transporter), member 2
chr11_-_7847518 0.940 NM_153445
OR5P3
olfactory receptor, family 5, subfamily P, member 3
chr3_+_46395224 0.938 NM_001123041
NM_001123396
CCR2

chemokine (C-C motif) receptor 2

chr10_-_108459000 0.937 SORCS1
sortilin-related VPS10 domain containing receptor 1
chr13_-_46756295 0.936 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr4_+_71226477 0.924 NM_012390
SMR3B
SMR3A
submaxillary gland androgen regulated protein 3B
submaxillary gland androgen regulated protein 3A
chrX_-_30595883 0.918 NM_025159
CXorf21
chromosome X open reading frame 21
chr6_-_41168923 0.916 NM_024807
TREML2
triggering receptor expressed on myeloid cells-like 2
chr18_+_32335939 0.911 NM_001390
NM_001391
DTNA

dystrobrevin, alpha

chrY_+_20708556 0.902 NM_153716
NM_001001877
NM_033108
NM_152584
HSFY2

HSFY1

heat shock transcription factor, Y linked 2

heat shock transcription factor, Y-linked 1

chr13_+_49684388 0.898 NM_014923
FNDC3A
fibronectin type III domain containing 3A
chrX_-_19817907 0.897 NM_001024666
SH3KBP1
SH3-domain kinase binding protein 1
chr8_-_145838887 0.891 NM_025251
ARHGAP39
Rho GTPase activating protein 39
chr18_+_59157774 0.885 NM_031891
CDH20
cadherin 20, type 2
chr6_+_47749774 0.882 NM_181744
OPN5
opsin 5
chr9_+_107456659 0.878 NM_001004484
OR13D1
olfactory receptor, family 13, subfamily D, member 1
chr19_+_840963 0.877 PRTN3
proteinase 3
chr2_+_135596185 0.877 NM_138326
ACMSD
aminocarboxymuconate semialdehyde decarboxylase
chr7_-_14880954 0.870 NM_004080
NM_145695
DGKB

diacylglycerol kinase, beta 90kDa

chr15_+_34638065 0.869 NM_175741
C15orf55
chromosome 15 open reading frame 55
chr3_+_44692500 0.866 ZNF35
zinc finger protein 35
chr1_-_201465700 0.862 NM_001193572
CSRP1
cysteine and glycine-rich protein 1
chr12_-_11175169 0.858 NM_176888
TAS2R19
taste receptor, type 2, member 19
chr1_-_152332481 0.854 NM_001014342
FLG2
filaggrin family member 2
chr19_+_840970 0.849 NM_002777
PRTN3
proteinase 3
chr11_+_122709205 0.849 NM_019604
CRTAM
cytotoxic and regulatory T cell molecule
chr19_+_55327892 0.838 NM_013289
KIR3DL1
killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
chr2_-_178753464 0.836 NM_001077196
PDE11A
phosphodiesterase 11A
chr4_-_139163222 0.823 NM_014331
SLC7A11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr18_+_52258389 0.814 NM_173629
C18orf26
chromosome 18 open reading frame 26
chr11_-_36619776 0.802 NM_000536
NM_001243785
NM_001243786
RAG2


recombination activating gene 2


chr21_-_15579243 0.799 NM_198996
LIPI
lipase, member I
chr17_-_67138013 0.792 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr4_-_70505359 0.791 NM_001105677
UGT2A2
UDP glucuronosyltransferase 2 family, polypeptide A2
chr6_+_31539875 0.788 NM_001159740
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr13_-_99910548 0.779 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chr21_-_31538970 0.778 NM_012131
CLDN17
claudin 17
chr7_-_45018650 0.773 MYO1G
myosin IG
chr10_+_11047253 0.773 NM_001025077
CELF2
CUGBP, Elav-like family member 2
chr11_+_71589498 0.767 NM_001242853
LOC100129216
beta-defensin 131-like
chrX_-_49965657 0.767 NM_003886
AKAP4
A kinase (PRKA) anchor protein 4
chr1_-_161279724 0.766 NM_000530
MPZ
myelin protein zero
chr4_-_76944585 0.764 NM_001565
CXCL10
chemokine (C-X-C motif) ligand 10
chr7_+_107110501 0.764 NM_005295
GPR22
G protein-coupled receptor 22
chr4_+_119948554 0.758 SYNPO2
synaptopodin 2
chr4_-_46125929 0.756 NM_173536
GABRG1
gamma-aminobutyric acid (GABA) A receptor, gamma 1
chr12_-_45307710 0.746 NM_001145110
NELL2
NEL-like 2 (chicken)
chr14_-_106610338 0.745 IGHV4-31
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant gamma 1 (G1m marker)
chr4_-_48136245 0.737 NM_003328
TXK
TXK tyrosine kinase
chr4_-_100273831 0.737 NM_000669
ADH1C
alcohol dehydrogenase 1C (class I), gamma polypeptide
chr4_+_88720701 0.731 NM_004967
IBSP
integrin-binding sialoprotein
chr14_-_107013474 0.726 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr2_-_228244005 0.726 NM_024795
TM4SF20
transmembrane 4 L six family member 20
chr21_-_33957746 0.717 NM_144659
TCP10L
t-complex 10 (mouse)-like
chr11_-_114466471 0.715 NM_001077639
NM_017678
FAM55D

family with sequence similarity 55, member D

chr5_+_40909558 0.713 NM_000587
C7
complement component 7
chr16_-_5116030 0.711 NM_001098514
NM_152459
C16orf89

chromosome 16 open reading frame 89

chrX_-_49965003 0.708 NM_139289
AKAP4
A kinase (PRKA) anchor protein 4
chr11_-_114466397 0.706 FAM55D
family with sequence similarity 55, member D
chr11_+_69455837 0.703 NM_053056
CCND1
cyclin D1
chr7_+_37723378 0.701


chr3_+_46619075 0.697 NM_003212
TDGF1
teratocarcinoma-derived growth factor 1
chr3_+_361365 0.697 NM_001253388
CHL1
cell adhesion molecule with homology to L1CAM (close homolog of L1)
chrX_+_125953746 0.697 NM_001122716
CXorf64
chromosome X open reading frame 64
chr1_+_148644010 0.693 NM_001144032
PPIAL4E
peptidylprolyl isomerase A (cyclophilin A)-like 4E
chr8_-_42623928 0.692 NM_001199279
NM_004198
CHRNA6

cholinergic receptor, nicotinic, alpha 6

chr13_+_24844846 0.679 SPATA13
spermatogenesis associated 13
chr14_-_106552313 0.677 IGHA1
IGHD
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 1 (G1m marker)
chr8_-_134115309 0.677 NM_001045556
NM_001045557
SLA

Src-like-adaptor

chr2_+_169643048 0.673 NM_001171631
NOSTRIN
nitric oxide synthase trafficker
chr4_-_71532206 0.672 IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr18_+_61575203 0.672 SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr4_-_16900028 0.672 LDB2
LIM domain binding 2
chr2_+_33738941 0.671 NM_015376
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr17_+_18647325 0.671 NM_031456
FBXW10
F-box and WD repeat domain containing 10
chr19_-_22034769 0.670 ZNF43
zinc finger protein 43
chr4_-_5711274 0.664 NM_001166136
EVC2
Ellis van Creveld syndrome 2
chr1_+_151611331 0.664 SNX27
sorting nexin family member 27
chr2_-_178973065 0.653 NM_001077197
PDE11A
phosphodiesterase 11A
chr5_-_94224601 0.651 MCTP1
multiple C2 domains, transmembrane 1
chr2_-_88285308 0.650 NM_001024457
RGPD1
RANBP2-like and GRIP domain containing 1
chr14_-_106714594 0.649


chr5_+_40909617 0.648 C7
complement component 7
chr12_+_21284127 0.648 NM_006446
SLCO1B1
solute carrier organic anion transporter family, member 1B1
chr10_+_96443250 0.645 NM_000772
NM_001128925
CYP2C18

cytochrome P450, family 2, subfamily C, polypeptide 18

chr2_+_68592432 0.643 PLEK
pleckstrin
chr2_+_36923902 0.641 VIT
vitrin
chr14_-_106774311 0.640 IGHA1
immunoglobulin heavy constant alpha 1
chrY_-_1281526 0.639 NM_001012288
NM_022148
CRLF2

cytokine receptor-like factor 2

chr19_+_9361605 0.639 NM_001079935
OR7E24
olfactory receptor, family 7, subfamily E, member 24
chr14_-_106791054 0.639 IGHV4-31
IGHV3-30
IGHA1
IGHD
IGHG1
IGHG2
IGHG3
IGHM
SCFV
immunoglobulin heavy variable 4-31
immunoglobulin heavy variable 3-30
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 2 (G2m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
single-chain Fv fragment
chr15_-_31947541 0.637 NM_130901
OTUD7A
OTU domain containing 7A
chr11_-_40315663 0.636 NM_020929
LRRC4C
leucine rich repeat containing 4C
chr5_+_57787260 0.636 NM_152687
GAPT
GRB2-binding adaptor protein, transmembrane
chr12_+_8325149 0.633 NM_001004328
ZNF705A
zinc finger protein 705A
chr2_-_174767282 0.619


chr11_-_10715297 0.619 MRVI1
murine retrovirus integration site 1 homolog
chr4_+_71296208 0.617 NM_001145006
MUC7
mucin 7, secreted
chr1_+_211519705 0.609 NM_145759
TRAF5
TNF receptor-associated factor 5
chr17_-_47925378 0.607 NM_001077503
NM_001077504
NM_001077505
NM_001077506
NM_170685
TAC4




tachykinin 4 (hemokinin)





Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
5.20 1.02e-04 GO:0006955 immune response
7.36 2.91e-04 GO:0045087 innate immune response
3.41 6.89e-03 GO:0002376 immune system process
42.02 1.71e-02 GO:0006586 indolalkylamine metabolic process
42.02 1.71e-02 GO:0042430 indole-containing compound metabolic process
17.70 2.73e-02 GO:0034339 regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor
8.23 3.05e-02 GO:0019221 cytokine-mediated signaling pathway
6.25 4.29e-02 GO:0034097 response to cytokine stimulus
3.77 4.51e-02 GO:0006952 defense response

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
2.89 2.18e-03 GO:0004872 receptor activity
19.78 4.79e-03 GO:0003707 steroid hormone receptor activity
18.68 6.01e-03 GO:0004879 ligand-dependent nuclear receptor activity
2.49 9.40e-03 GO:0004871 signal transducer activity
2.49 9.40e-03 GO:0060089 molecular transducer activity
72.03 3.28e-02 GO:0004908 interleukin-1 receptor activity
63.03 4.37e-02 GO:0042805 actinin binding