Motif ID: PITX1..3.p2

Z-value: 1.799


Transcription factors associated with PITX1..3.p2:

Gene SymbolEntrez IDGene Name
PITX1 5307 paired-like homeodomain 1
PITX2 5308 paired-like homeodomain 2
PITX3 5309 paired-like homeodomain 3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PITX1hg19_v1_chr5_-_134369841_1343699780.615.9e-09Click!
PITX2hg19_v1_chr4_-_111563278_111563278-0.103.8e-01Click!
PITX3hg19_v1_chr10_-_104001229_1040012300.075.7e-01Click!


Activity profile for motif PITX1..3.p2.

activity profile for motif PITX1..3.p2


Sorted Z-values histogram for motif PITX1..3.p2

Sorted Z-values for motif PITX1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PITX1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_39033981 8.829 NM_024943
TMEM156
transmembrane protein 156
chr1_-_161207879 8.111 NM_001077469
NM_001077470
NM_001077471
NM_001077472
NM_001077473
NM_001077474
NM_001077475
NM_001077476
NM_001077477
NM_001077478
NM_001077479
NM_001077480
NM_001077481
NM_001077482
NM_005122
NR1I3














nuclear receptor subfamily 1, group I, member 3














chr16_+_72042486 7.406 NM_001361
DHODH
dihydroorotate dehydrogenase (quinone)
chr5_+_159656436 6.463 NM_001445
FABP6
fatty acid binding protein 6, ileal
chrX_+_9431314 6.401 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr19_+_49078992 6.282 NM_004605
SULT2B1
sulfotransferase family, cytosolic, 2B, member 1
chr7_-_100858312 6.003 PLOD3
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
chr22_+_35779103 5.582 HMOX1
heme oxygenase (decycling) 1
chr20_+_61476475 5.303 NM_080750
DPH3P1
DPH3, KTI11 homolog (S. cerevisiae) pseudogene 1
chr19_-_35981345 5.194 NM_001244847
NM_207392
KRTDAP

keratinocyte differentiation-associated protein

chrX_-_15620191 5.078 NM_021804
ACE2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr19_+_47840370 5.013 NM_018485
GPR77
G protein-coupled receptor 77
chr19_+_12863406 4.886 NM_017682
BEST2
bestrophin 2
chr19_+_45174723 4.743 NM_001127893
NM_020219
CEACAM19

carcinoembryonic antigen-related cell adhesion molecule 19

chr19_-_5870546 4.731 NM_002034
FUT5
fucosyltransferase 5 (alpha (1,3) fucosyltransferase)
chr22_-_43036606 4.602 NM_001165877
ATP5L2
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G2
chr6_-_26189303 4.564 NM_003539
HIST1H4D
histone cluster 1, H4d
chr15_-_55800431 4.167 NM_001033559
NM_001033560
NM_130810
DYX1C1


dyslexia susceptibility 1 candidate 1


chr3_+_195447810 3.967 MUC20
mucin 20, cell surface associated
chr1_+_40859016 3.956 NM_001198979
SMAP2
small ArfGAP2
chr3_-_49757058 3.949 NM_198722
AMIGO3
adhesion molecule with Ig-like domain 3
chr17_-_38210611 3.852 MED24
mediator complex subunit 24
chr19_-_54692132 3.800 MBOAT7
membrane bound O-acyltransferase domain containing 7
chr19_-_46142643 3.789 EML2
echinoderm microtubule associated protein like 2
chr19_+_45281125 3.733 NM_001130852
NM_012116
CBLC

Cas-Br-M (murine) ecotropic retroviral transforming sequence c

chr19_-_46142662 3.724 NM_012155
EML2
echinoderm microtubule associated protein like 2
chr20_-_62436855 3.681 NM_025224
ZBTB46
zinc finger and BTB domain containing 46
chr1_-_16134192 3.643 NM_001089591
UQCRHL
ubiquinol-cytochrome c reductase hinge protein-like
chr16_+_29471206 3.591 NM_001017390
NM_177552
SULT1A4
SULT1A3
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr15_-_74495093 3.565 NM_001199042
NM_022369
STRA6

stimulated by retinoic acid gene 6 homolog (mouse)

chr19_+_45596159 3.559 PPP1R37
protein phosphatase 1, regulatory subunit 37
chr9_-_116138340 3.495 NM_031219
HDHD3
haloacid dehalogenase-like hydrolase domain containing 3
chr7_+_73624328 3.483 LAT2
linker for activation of T cells family, member 2
chr17_-_79838899 3.463


chr16_+_30210548 3.442 NM_001017390
NM_177552
SULT1A4
SULT1A3
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr3_+_48264836 3.436 NM_004345
CAMP
cathelicidin antimicrobial peptide
chr19_+_54960064 3.418 NM_052925
LENG8
leukocyte receptor cluster (LRC) member 8
chr20_-_4990913 3.410 NM_203327
SLC23A2
solute carrier family 23 (nucleobase transporters), member 2
chr16_-_21854755 3.397 LOC100132247
NPIPL3
LOC613037
nuclear pore complex interacting protein related gene
nuclear pore complex interacting protein-like 3
nuclear pore complex interacting protein pseudogene
chr12_-_123594974 3.321 NM_020845
PITPNM2
phosphatidylinositol transfer protein, membrane-associated 2
chr6_-_74162036 3.296 NM_138441
MB21D1
Mab-21 domain containing 1
chr6_-_74161978 3.281 MB21D1
Mab-21 domain containing 1
chr9_-_117156684 3.278 NM_030767
AKNA
AT-hook transcription factor
chr12_-_8043743 3.259 SLC2A14
solute carrier family 2 (facilitated glucose transporter), member 14
chr10_-_99160987 3.240 RRP12
ribosomal RNA processing 12 homolog (S. cerevisiae)
chr5_+_176811431 3.231 NM_001167579
NM_003052
SLC34A1

solute carrier family 34 (sodium phosphate), member 1

chr17_-_48271365 3.222


chr19_+_54619114 3.166 PRPF31
PRP31 pre-mRNA processing factor 31 homolog (S. cerevisiae)
chr10_-_99161013 3.138 NM_001145114
NM_015179
RRP12

ribosomal RNA processing 12 homolog (S. cerevisiae)

chr19_-_2085227 3.121 MOB3A
MOB kinase activator 3A
chr19_+_50431958 3.109 NM_012068
ATF5
activating transcription factor 5
chr19_+_54619149 3.103 PRPF31
PRP31 pre-mRNA processing factor 31 homolog (S. cerevisiae)
chr1_-_153348057 3.087 NM_005621
S100A12
S100 calcium binding protein A12
chr16_+_88003623 3.067 NM_001173543
BANP
BTG3 associated nuclear protein
chr19_-_5839702 3.039 NM_000150
NM_001040701
FUT6

fucosyltransferase 6 (alpha (1,3) fucosyltransferase)

chr1_-_228291040 2.905 C1orf35
chromosome 1 open reading frame 35
chrX_-_129272014 2.904 NM_001130846
AIFM1
apoptosis-inducing factor, mitochondrion-associated, 1
chr10_+_96443250 2.901 NM_000772
NM_001128925
CYP2C18

cytochrome P450, family 2, subfamily C, polypeptide 18

chr19_-_45873641 2.861 ERCC2
excision repair cross-complementing rodent repair deficiency, complementation group 2
chr6_-_42162693 2.859 NM_002098
GUCA1B
guanylate cyclase activator 1B (retina)
chr2_-_27357288 2.852 PREB
prolactin regulatory element binding
chr3_+_195447751 2.844 NM_152673
MUC20
mucin 20, cell surface associated
chr22_-_24096551 2.842 NM_013378
VPREB3
pre-B lymphocyte 3
chr8_-_27941387 2.834 NM_001010906
C8orf80
chromosome 8 open reading frame 80
chr11_-_2018334 2.826 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr1_+_9005921 2.826 NM_001215
CA6
carbonic anhydrase VI
chr7_+_73624086 2.804 NM_014146
NM_032463
NM_032464
LAT2


linker for activation of T cells family, member 2


chr19_+_15160194 2.776 NM_012114
CASP14
caspase 14, apoptosis-related cysteine peptidase
chr2_-_27357519 2.773 NM_013388
PREB
prolactin regulatory element binding
chr19_-_45873839 2.764 NM_000400
NM_001130867
ERCC2

excision repair cross-complementing rodent repair deficiency, complementation group 2

chr15_-_65398578 2.754 NM_001163692
UBAP1L
ubiquitin associated protein 1-like
chr11_-_63330854 2.748 NM_017878
HRASLS2
HRAS-like suppressor 2
chr1_-_53238341 2.747


chr19_+_860615 2.742 CFD
complement factor D (adipsin)
chr19_-_10291056 2.735


chr4_-_23891608 2.713 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr14_-_50862616 2.713 NM_004196
CDKL1
cyclin-dependent kinase-like 1 (CDC2-related kinase)
chr22_-_21984366 2.658 YDJC
YdjC homolog (bacterial)
chr19_-_12845469 2.658 C19orf43
chromosome 19 open reading frame 43
chr17_-_3599359 2.657 P2RX5
purinergic receptor P2X, ligand-gated ion channel, 5
chr2_-_27357486 2.655 PREB
prolactin regulatory element binding
chr11_-_17410205 2.655 NM_000525
KCNJ11
potassium inwardly-rectifying channel, subfamily J, member 11
chr17_-_81006406 2.649 B3GNTL1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1
chr19_+_14491920 2.645 NM_001025160
NM_001784
NM_078481
CD97


CD97 molecule


chr1_+_6684924 2.643 NM_001195753
THAP3
THAP domain containing, apoptosis associated protein 3
chr2_-_230933618 2.628 NM_152527
SLC16A14
solute carrier family 16, member 14 (monocarboxylic acid transporter 14)
chr19_+_6361558 2.614 CLPP
ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli)
chr20_+_62492565 2.609 NM_080622
ABHD16B
abhydrolase domain containing 16B
chr2_+_169643048 2.564 NM_001171631
NOSTRIN
nitric oxide synthase trafficker
chr1_-_228290929 2.551 NM_024319
C1orf35
chromosome 1 open reading frame 35
chr22_-_21984274 2.529 NM_001017964
YDJC
YdjC homolog (bacterial)
chr19_+_37808780 2.523 HKR1
HKR1, GLI-Kruppel zinc finger family member
chr6_-_31763551 2.517 NM_006295
VARS
valyl-tRNA synthetase
chr20_+_361272 2.515 NM_021158
TRIB3
tribbles homolog 3 (Drosophila)
chr7_+_73624252 2.513 LAT2
linker for activation of T cells family, member 2
chr12_+_57881853 2.510 MARS
methionyl-tRNA synthetase
chr19_+_54960380 2.508 LENG8
leukocyte receptor cluster (LRC) member 8
chr22_+_32753853 2.500 NM_001098535
RFPL3
ret finger protein-like 3
chr12_-_121736110 2.481 NM_006549
NM_153499
NM_153500
NM_172214
NM_172215
NM_172216
CAMKK2





calcium/calmodulin-dependent protein kinase kinase 2, beta





chr5_+_157184338 2.464


chr11_-_2019007 2.439 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr17_-_6338425 2.421 NM_001033054
NM_001033055
NM_014336
AIPL1


aryl hydrocarbon receptor interacting protein-like 1


chr6_+_35704858 2.416 NM_145028
C6orf81
chromosome 6 open reading frame 81
chr12_+_57881735 2.415 NM_004990
MARS
methionyl-tRNA synthetase
chr17_-_76975932 2.414 NM_005567
LGALS3BP
lectin, galactoside-binding, soluble, 3 binding protein
chr1_+_114496498 2.401 NM_181358
HIPK1
homeodomain interacting protein kinase 1
chr7_-_99381703 2.381 NM_001202855
NM_017460
CYP3A4

cytochrome P450, family 3, subfamily A, polypeptide 4

chr1_-_29309092 2.366


chr1_+_15990300 2.361


chr4_+_2627158 2.357 NM_003704
FAM193A
family with sequence similarity 193, member A
chr2_-_27357515 2.353 PREB
prolactin regulatory element binding
chr19_+_45542295 2.343 NM_007056
CLASRP
CLK4-associating serine/arginine rich protein
chr6_-_73935174 2.332 NM_001126063
KHDC1L
KH homology domain containing 1-like
chr1_+_12079298 2.306 NM_021933
MIIP
migration and invasion inhibitory protein
chr17_+_17380264 2.296 NM_018019
MED9
mediator complex subunit 9
chr4_+_41983712 2.293 NM_001029955
DCAF4L1
DDB1 and CUL4 associated factor 4-like 1
chr1_+_111772332 2.280 NM_001025199
CHI3L2
chitinase 3-like 2
chr2_-_74692501 2.266 MOGS
mannosyl-oligosaccharide glucosidase
chr1_+_225997804 2.254 EPHX1
epoxide hydrolase 1, microsomal (xenobiotic)
chr6_-_32098051 2.254 NM_022110
FKBPL
FK506 binding protein like
chr1_+_200182655 2.250 NM_001105517
FAM58BP
family with sequence similarity 58, member B, pseudogene
chr19_+_47852537 2.243 NM_014681
DHX34
DEAH (Asp-Glu-Ala-His) box polypeptide 34
chr1_+_225997742 2.233 NM_001136018
EPHX1
epoxide hydrolase 1, microsomal (xenobiotic)
chr22_-_38240341 2.232 NM_138797
ANKRD54
ankyrin repeat domain 54
chr2_-_74692534 2.191 NM_001146158
NM_006302
MOGS

mannosyl-oligosaccharide glucosidase

chr11_-_66675334 2.190 NM_022172
PC
pyruvate carboxylase
chr19_-_14889347 2.184 NM_013447
NM_152916
NM_152917
NM_152918
NM_152919
NM_152920
NM_152921
EMR2






egf-like module containing, mucin-like, hormone receptor-like 2






chr17_+_40703983 2.177 NM_000413
HSD17B1
hydroxysteroid (17-beta) dehydrogenase 1
chr19_-_48744276 2.170 NM_001184900
CARD8
caspase recruitment domain family, member 8
chr4_+_189060597 2.169 NM_178556
TRIML1
tripartite motif family-like 1
chr11_+_112832281 2.157 NCAM1
neural cell adhesion molecule 1
chr7_+_73624347 2.152 LAT2
linker for activation of T cells family, member 2
chr6_-_33548017 2.151 NM_001188
BAK1
BCL2-antagonist/killer 1
chr11_-_64647136 2.144 EHD1
EH-domain containing 1
chr15_-_74494851 2.136 STRA6
stimulated by retinoic acid gene 6 homolog (mouse)
chr19_-_2096280 2.135 MOB3A
MOB kinase activator 3A
chr11_-_2018446 2.125 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr16_-_28621279 2.125 NM_001055
NM_177529
SULT1A1

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

chr15_+_40509628 2.100 NM_001128628
NM_001128629
PAK6

p21 protein (Cdc42/Rac)-activated kinase 6

chr19_+_18045904 2.092 NM_138442
CCDC124
coiled-coil domain containing 124
chr22_-_36635999 2.087 NM_145637
APOL2
apolipoprotein L, 2
chr9_+_131464770 2.079 NM_013355
PKN3
protein kinase N3
chr18_-_14132426 2.079 NM_145287
ZNF519
zinc finger protein 519
chr7_+_99724319 2.077 NM_203397
MBLAC1
metallo-beta-lactamase domain containing 1
chr3_+_49506079 2.075 NM_001177643
DAG1
dystroglycan 1 (dystrophin-associated glycoprotein 1)
chr11_-_66639602 2.072


chr19_-_5846465 2.067 FUT3
fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
chr19_+_1241766 2.049 ATP5D
ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
chr11_-_62607627 2.048 NM_018093
WDR74
WD repeat domain 74
chr19_-_56739658 2.047 NM_024303
ZSCAN5A
zinc finger and SCAN domain containing 5A
chr14_+_105196225 2.045 NM_199165
ADSSL1
adenylosuccinate synthase like 1
chr19_-_58662144 2.043 NM_024620
ZNF329
zinc finger protein 329
chr19_+_47813074 2.042 NM_001736
C5AR1
complement component 5a receptor 1
chr13_+_24734788 2.037 NM_001166271
NM_153023
SPATA13

spermatogenesis associated 13

chr16_+_103009 2.036 SNRNP25
small nuclear ribonucleoprotein 25kDa (U11/U12)
chr16_-_28634873 2.031 NM_177536
SULT1A1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr9_-_136214557 2.029 MED22
mediator complex subunit 22
chr17_-_3599487 2.026 NM_001204519
NM_001204520
NM_002561
NM_175080
P2RX5-TAX1BP3
P2RX5



P2RX5-TAX1BP3 readthrough
purinergic receptor P2X, ligand-gated ion channel, 5



chr19_+_49956492 2.023 ALDH16A1
aldehyde dehydrogenase 16 family, member A1
chr19_+_1241767 2.016 ATP5D
ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
chr16_-_28608367 2.013 NM_001054
SULT1A2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr22_+_20918810 2.008 MED15
mediator complex subunit 15
chr19_+_38810751 2.008 KCNK6
potassium channel, subfamily K, member 6
chr2_-_96950421 2.004 SNRNP200
small nuclear ribonucleoprotein 200kDa (U5)
chr3_-_124842442 2.000 SLC12A8
solute carrier family 12 (potassium/chloride transporters), member 8
chr20_-_44006876 1.993 NM_014477
TP53TG5
TP53 target 5
chrX_+_149613719 1.991 NM_001177466
NM_005491
MAMLD1

mastermind-like domain containing 1

chr17_-_73761216 1.987 NM_000154
GALK1
galactokinase 1
chr11_+_12308446 1.981 NM_032867
MICALCL
MICAL C-terminal like
chr20_+_43990576 1.980 NM_001197129
SYS1
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)
chr5_-_10308167 1.978 NM_138809
CMBL
carboxymethylenebutenolidase homolog (Pseudomonas)
chr15_-_41836442 1.974 RPAP1
RNA polymerase II associated protein 1
chr17_+_34087915 1.972 NM_145272
C17orf50
chromosome 17 open reading frame 50
chr9_-_116139148 1.970 HDHD3
haloacid dehalogenase-like hydrolase domain containing 3
chr11_-_2018885 1.962 H19
RPS12
H19, imprinted maternally expressed transcript (non-protein coding)
ribosomal protein S12
chr20_-_1309809 1.956 NM_080489
SDCBP2
syndecan binding protein (syntenin) 2
chr19_-_2096263 1.952 NM_130807
MOB3A
MOB kinase activator 3A
chr15_-_41836458 1.950 NM_015540
RPAP1
RNA polymerase II associated protein 1
chr1_+_234509213 1.936 NM_001206641
NM_001012985
C1orf31

chromosome 1 open reading frame 31

chr19_-_12845516 1.936 NM_024038
C19orf43
chromosome 19 open reading frame 43
chr1_+_204042191 1.935 NM_005686
SOX13
SRY (sex determining region Y)-box 13
chrX_-_80457440 1.932 NM_030763
HMGN5
high mobility group nucleosome binding domain 5
chr19_+_1241742 1.931 NM_001001975
NM_001687
ATP5D

ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit

chr7_+_5920426 1.928 NM_001097622
OCM
oncomodulin
chr11_-_46612913 1.927 NM_017749
AMBRA1
autophagy/beclin-1 regulator 1
chr19_+_38826442 1.925 NM_021185
CATSPERG
cation channel, sperm-associated, gamma
chr19_-_12845480 1.922 C19orf43
chromosome 19 open reading frame 43
chrX_+_198060 1.921 NM_018390
PLCXD1
phosphatidylinositol-specific phospholipase C, X domain containing 1
chr19_+_49956472 1.920 NM_001145396
NM_153329
ALDH16A1

aldehyde dehydrogenase 16 family, member A1

chr6_-_33547833 1.917 BAK1
BCL2-antagonist/killer 1
chr17_-_8151353 1.908 CTC1
CTS telomere maintenance complex component 1
chr9_+_120466453 1.906 NM_138554
TLR4
toll-like receptor 4
chr15_-_23034406 1.901 NM_001008860
NM_001008892
NM_001008894
NM_001184888
NM_001184889
NM_030922
NIPA2





non imprinted in Prader-Willi/Angelman syndrome 2





chrY_+_148060 1.900 NM_018390
PLCXD1
phosphatidylinositol-specific phospholipase C, X domain containing 1
chr7_+_65579846 1.899 CRCP
CGRP receptor component
chr9_+_132388451 1.892 METTL11A
methyltransferase like 11A
chr1_+_10509775 1.891 NM_001302
CORT
cortistatin
chr20_-_3996035 1.890 NM_007219
NM_001134337
NM_001134338
RNF24


ring finger protein 24


chr9_+_127054246 1.889 NM_001166170
NM_001166171
NEK6

NIMA (never in mitosis gene a)-related kinase 6

chr12_-_122296619 1.882 NM_002150
HPD
4-hydroxyphenylpyruvate dioxygenase

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
3.54 3.03e-02 GO:0019318 hexose metabolic process
4.65 3.14e-02 GO:0044275 cellular carbohydrate catabolic process
1.28 3.84e-02 GO:0044237 cellular metabolic process
4.92 4.47e-02 GO:0046164 alcohol catabolic process

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
3.75 1.96e-02 GO:0005681 spliceosomal complex

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
41.80 4.23e-03 GO:0017060 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity
8.96 1.34e-02 GO:0016455 RNA polymerase II transcription mediator activity
31.35 1.66e-02 GO:0004062 aryl sulfotransferase activity
1.29 3.24e-02 GO:0003824 catalytic activity