Motif ID: PDX1.p2

Z-value: 0.557


Transcription factors associated with PDX1.p2:

Gene SymbolEntrez IDGene Name
PDX1 3651 pancreatic and duodenal homeobox 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PDX1hg19_v1_chr13_+_28494136_28494272-0.413.0e-04Click!


Activity profile for motif PDX1.p2.

activity profile for motif PDX1.p2


Sorted Z-values histogram for motif PDX1.p2

Sorted Z-values for motif PDX1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PDX1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_-_40398286 5.087 NM_001003942
NM_001003943
BMF

Bcl2 modifying factor

chr2_+_113735595 3.871 NM_019618
IL36G
interleukin 36, gamma
chr4_+_86396251 3.335 NM_001025616
ARHGAP24
Rho GTPase activating protein 24
chr3_+_100238063 3.242 TMEM45A
transmembrane protein 45A
chr6_-_133035180 3.011 NM_004666
VNN1
vanin 1
chr7_-_92777657 2.841 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr6_-_31107110 2.727 NM_014069
PSORS1C2
psoriasis susceptibility 1 candidate 2
chr15_+_67841341 2.137 NM_001206804
MAP2K5
mitogen-activated protein kinase kinase 5
chr10_+_63808968 2.080 NM_001244638
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr15_-_40398573 1.904 NM_033503
BMF
Bcl2 modifying factor
chr15_-_44969085 1.778 NM_001145112
PATL2
protein associated with topoisomerase II homolog 2 (yeast)
chr6_-_134498973 1.694 NM_001143677
SGK1
serum/glucocorticoid regulated kinase 1
chr1_+_158979681 1.505 NM_001206567
NM_005531
IFI16

interferon, gamma-inducible protein 16

chr6_-_43423785 1.492 NM_206539
DLK2
delta-like 2 homolog (Drosophila)
chr3_-_108672547 1.488 NM_005459
GUCA1C
guanylate cyclase activator 1C
chr15_+_25281105 1.485 SNRPN
small nuclear ribonucleoprotein polypeptide N
chr7_+_80267972 1.402 CD36
CD36 molecule (thrombospondin receptor)
chr2_-_201967702 1.384


chr3_+_174577069 1.267 NM_207015
NAALADL2
N-acetylated alpha-linked acidic dipeptidase-like 2
chr11_+_22696381 1.093 GAS2
growth arrest-specific 2
chr4_-_68995586 1.077 NM_207407
TMPRSS11F
transmembrane protease, serine 11F
chr3_-_143567163 1.076 NM_173653
SLC9A9
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr19_+_48828627 1.027 NM_001425
EMP3
epithelial membrane protein 3
chr16_-_70557430 1.009 NM_001195139
NM_015386
COG4

component of oligomeric golgi complex 4

chr5_+_140201221 0.995 NM_018908
NM_031501
PCDHA5

protocadherin alpha 5

chr12_+_47610051 0.988 NM_138371
FAM113B
family with sequence similarity 113, member B
chr4_+_74606222 0.983 NM_000584
IL8
interleukin 8
chr4_-_176733413 0.941 GPM6A
glycoprotein M6A
chr11_+_111789600 0.821 NM_080659
C11orf52
chromosome 11 open reading frame 52
chr1_+_10057254 0.785 NM_052960
RBP7
retinol binding protein 7, cellular
chr9_+_82187469 0.775 TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr5_+_42565562 0.725 NM_001242406
GHR
growth hormone receptor
chr14_-_81864726 0.710 NM_033104
STON2
stonin 2
chr21_-_46348633 0.691 NM_001127491
ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr14_-_77889231 0.686 NM_001113475
NOXRED1
NADP-dependent oxidoreductase domain containing 1
chr19_-_36019194 0.686 NM_001166034
NM_001166035
NM_198538
SBSN


suprabasin


chr5_+_147582338 0.668 NM_001195290
NM_205841
SPINK6

serine peptidase inhibitor, Kazal type 6

chr11_+_123986103 0.661 NM_001130142
NM_014622
NM_198315
VWA5A


von Willebrand factor A domain containing 5A


chr1_+_92632608 0.574 NM_015237
KIAA1107
KIAA1107
chr5_+_147648374 0.572 NM_001040129
SPINK13
serine peptidase inhibitor, Kazal type 13 (putative)
chr16_+_28505920 0.558 NM_018690
APOBR
apolipoprotein B receptor
chr8_-_17580024 0.548 NM_001166393
MTUS1
microtubule associated tumor suppressor 1
chr4_-_176733378 0.543 GPM6A
glycoprotein M6A
chr12_+_51318515 0.536 NM_014033
METTL7A
methyltransferase like 7A
chr16_+_19078916 0.535 NM_016138
COQ7
coenzyme Q7 homolog, ubiquinone (yeast)
chr16_+_19078958 0.531 COQ7
coenzyme Q7 homolog, ubiquinone (yeast)
chr10_+_90484300 0.523 NM_001080518
LIPK
lipase, family member K
chr2_-_216259197 0.514 FN1
fibronectin 1
chr8_-_17579729 0.505 NM_001001931
MTUS1
microtubule associated tumor suppressor 1
chr1_-_29309092 0.488


chr7_+_80275967 0.486 CD36
CD36 molecule (thrombospondin receptor)
chr8_-_17555158 0.480 NM_020749
MTUS1
microtubule associated tumor suppressor 1
chr16_+_8814567 0.477 NM_001127448
ABAT
4-aminobutyrate aminotransferase
chr9_+_82187599 0.476 TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr18_+_28898051 0.475 NM_001942
DSG1
desmoglein 1
chr11_+_22696318 0.462 NM_005256
GAS2
growth arrest-specific 2
chr2_+_169921298 0.457 NM_005771
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr12_+_75784878 0.443 NM_152436
GLIPR1L2
GLI pathogenesis-related 1 like 2
chrX_-_10645726 0.424 NM_001098624
MID1
midline 1 (Opitz/BBB syndrome)
chr12_+_47610244 0.401 FAM113B
family with sequence similarity 113, member B
chr12_+_31800093 0.399 NM_001135864
METTL20
methyltransferase like 20
chr16_+_19079220 0.397 NM_001190983
COQ7
coenzyme Q7 homolog, ubiquinone (yeast)
chr5_+_140718353 0.396 NM_018915
NM_032009
PCDHGA2

protocadherin gamma subfamily A, 2

chr17_+_7482938 0.391 CD68
CD68 molecule
chr10_+_32856650 0.389 NM_024688
C10orf68
chromosome 10 open reading frame 68
chr3_-_123339423 0.373 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr17_+_7482980 0.369 CD68
CD68 molecule
chr7_-_44228880 0.348 NM_000162
GCK
glucokinase (hexokinase 4)
chr3_-_21792815 0.347 NM_024697
ZNF385D
zinc finger protein 385D
chr17_+_7482961 0.340 CD68
CD68 molecule
chr2_+_169926084 0.333 DHRS9
dehydrogenase/reductase (SDR family) member 9
chr1_+_159175048 0.332 NM_001122951
DARC
Duffy blood group, chemokine receptor
chr8_-_145060594 0.326 NM_032789
PARP10
poly (ADP-ribose) polymerase family, member 10
chr1_-_152061529 0.323 NM_001008536
TCHHL1
trichohyalin-like 1
chr4_+_169013687 0.317 NM_007193
ANXA10
annexin A10
chr7_-_128543379 0.310 KCP
kielin/chordin-like protein
chr1_-_152196668 0.302 NM_001009931
HRNR
hornerin
chr5_+_140235594 0.302 NM_018901
NM_031859
NM_031860
PCDHA10


protocadherin alpha 10


chr9_+_97766414 0.302 C9orf3
chromosome 9 open reading frame 3
chr3_-_45017600 0.301 NM_001135179
NM_016598
ZDHHC3

zinc finger, DHHC-type containing 3

chr18_+_616671 0.288 NM_199167
CLUL1
clusterin-like 1 (retinal)
chr10_-_56560947 0.266 NM_001142763
NM_001142764
NM_001142765
NM_001142766
NM_001142767
NM_001142768
NM_001142769
NM_001142770
NM_001142771
NM_001142772
NM_001142773
NM_033056
PCDH15











protocadherin-related 15











chr5_-_147286064 0.261 NM_206966
C5orf46
chromosome 5 open reading frame 46
chr4_-_176733901 0.251 GPM6A
glycoprotein M6A
chr21_+_19617145 0.241 NM_024944
CHODL
chondrolectin
chr5_-_16509106 0.240 NM_019000
FAM134B
family with sequence similarity 134, member B
chr12_-_54020081 0.226 NM_001130060
NM_001206682
NM_006856
ATF7


activating transcription factor 7


chr12_-_54019633 0.222 NM_001206683
ATF7
activating transcription factor 7
chr5_+_140227356 0.208 NM_014005
NM_031857
PCDHA9

protocadherin alpha 9

chr10_+_116697914 0.203 NM_139169
TRUB1
TruB pseudouridine (psi) synthase homolog 1 (E. coli)
chr19_-_7766978 0.196 NM_001220500
NM_002002
FCER2

Fc fragment of IgE, low affinity II, receptor for (CD23)

chr17_+_7482804 0.188 NM_001251
NM_001040059
CD68

CD68 molecule

chr3_-_178969644 0.184 NM_171830
KCNMB3
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr12_+_75784849 0.178 GLIPR1L2
GLI pathogenesis-related 1 like 2
chr19_-_50847957 0.163 NAPSB
napsin B aspartic peptidase pseudogene
chr18_+_31319154 0.162 ASXL3
additional sex combs like 3 (Drosophila)
chr8_+_32579350 0.155 NM_001159996
NRG1
neuregulin 1
chr7_-_99474655 0.152 NM_001005276
OR2AE1
olfactory receptor, family 2, subfamily AE, member 1
chr2_-_166060552 0.145 NM_001081676
NM_001081677
NM_006922
SCN3A


sodium channel, voltage-gated, type III, alpha subunit


chr17_+_39555993 0.145 GAST
gastrin
chr3_-_114343791 0.140 NM_001164346
ZBTB20
zinc finger and BTB domain containing 20
chr17_+_47923271 0.140 NM_001242791
FLJ45513
uncharacterized LOC729220
chr6_-_51952368 0.138 NM_138694
NM_170724
PKHD1

polycystic kidney and hepatic disease 1 (autosomal recessive)

chr9_+_97521930 0.137 NM_001193329
C9orf3
chromosome 9 open reading frame 3
chr7_+_156435670 0.137 NM_001184997
RNF32
ring finger protein 32
chr1_+_13911966 0.135 NM_001006624
NM_001006625
PDPN

podoplanin

chr7_-_27166638 0.134 NM_153631
HOXA3
homeobox A3
chr19_-_14952688 0.129 NM_001005190
OR7A10
olfactory receptor, family 7, subfamily A, member 10
chr5_-_142815076 0.124 NM_001018074
NM_001018075
NM_001018077
NR3C1


nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


chr11_+_61976139 0.114 NM_002407
SCGB2A1
secretoglobin, family 2A, member 1
chr17_+_7960201 0.108


chr6_+_46761093 0.106 NM_005588
MEP1A
meprin A, alpha (PABA peptide hydrolase)
chr16_-_48269087 0.102 NM_032583
NM_145186
ABCC11

ATP-binding cassette, sub-family C (CFTR/MRP), member 11

chr17_-_7082654 0.098 NM_001197216
NM_001671
ASGR1

asialoglycoprotein receptor 1

chr10_+_88730497 0.098 NM_133447
AGAP11
ankyrin repeat and GTPase domain Arf GTPase activating protein 11
chr3_-_151034514 0.097 NM_023915
GPR87
G protein-coupled receptor 87
chr3_-_137832321 0.094 NM_001170538
DZIP1L
DAZ interacting protein 1-like
chr6_+_131571298 0.091 NM_004842
NM_138633
AKAP7

A kinase (PRKA) anchor protein 7

chr1_+_43735664 0.089 NM_144626
TMEM125
transmembrane protein 125
chr17_+_38119225 0.089 NM_178171
GSDMA
gasdermin A
chr3_+_197879236 0.088 NM_001145248
FAM157A
family with sequence similarity 157, member A
chr7_+_129984629 0.087 NM_001127441
NM_001127442
NM_080385
CPA5


carboxypeptidase A5


chr3_-_114478117 0.087 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr5_+_76382458 0.085 LOC728723
uncharacterized LOC728723
chr16_+_57728711 0.081 NM_032269
CCDC135
coiled-coil domain containing 135
chr1_+_84768333 0.080 NM_001134664
SAMD13
sterile alpha motif domain containing 13
chr12_-_14849427 0.079 NM_004963
GUCY2C
guanylate cyclase 2C (heat stable enterotoxin receptor)
chr12_+_15475190 0.073 NM_002848
NM_030667
PTPRO

protein tyrosine phosphatase, receptor type, O

chr6_+_72922513 0.071 NM_001168407
NM_001168408
RIMS1

regulating synaptic membrane exocytosis 1

chr5_+_68667280 0.071 NM_133339
RAD17
RAD17 homolog (S. pombe)
chr13_-_95131718 0.065 NM_001129889
NM_001922
DCT

dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)

chr12_-_9885859 0.064 NM_001253748
NM_001253750
NM_172004
CLECL1


C-type lectin-like 1


chr1_-_186417855 0.060 NM_022576
PDC
phosducin
chr13_-_41593491 0.055 NM_172373
ELF1
E74-like factor 1 (ets domain transcription factor)
chr4_+_88896801 0.054 NM_000582
NM_001040058
NM_001040060
NM_001251829
NM_001251830
SPP1




secreted phosphoprotein 1




chr3_+_108541544 0.050 NM_016388
TRAT1
T cell receptor associated transmembrane adaptor 1
chr1_+_28764660 0.050 NM_023923
PHACTR4
phosphatase and actin regulator 4
chr1_+_36748164 0.050 THRAP3
thyroid hormone receptor associated protein 3
chr6_-_131321868 0.048 NM_001252660
EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr6_+_167704802 0.047 NM_001143947
NM_018974
UNC93A

unc-93 homolog A (C. elegans)

chr12_-_103311380 0.047 NM_000277
PAH
phenylalanine hydroxylase
chr6_+_72926144 0.046 NM_001168409
RIMS1
regulating synaptic membrane exocytosis 1
chr12_-_57873364 0.042 NM_001080157
ARHGAP9
Rho GTPase activating protein 9
chr16_+_29674282 0.042 NM_001030288
SPN
sialophorin
chr2_+_137748461 0.040 NM_001080427
THSD7B
thrombospondin, type I, domain containing 7B
chr7_-_44580857 0.039 NM_001101648
NM_013389
NPC1L1

NPC1 (Niemann-Pick disease, type C1, gene)-like 1

chr3_+_46619075 0.038 NM_003212
TDGF1
teratocarcinoma-derived growth factor 1
chr3_+_35683848 0.038 NM_016300
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr10_-_62332666 0.037 NM_001204404
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr1_+_163038934 0.037 NM_001113381
RGS4
regulator of G-protein signaling 4
chr12_+_80838125 0.035 NM_001145026
PTPRQ
protein tyrosine phosphatase, receptor type, Q
chr8_-_27115935 0.034 STMN4
stathmin-like 4
chr10_+_118187381 0.034 NM_001011709
PNLIPRP3
pancreatic lipase-related protein 3
chr12_+_21525801 0.028 NM_000415
IAPP
islet amyloid polypeptide
chr6_+_42531736 0.027 NM_001184801
NM_015255
UBR2

ubiquitin protein ligase E3 component n-recognin 2

chr12_-_4488707 0.026 NM_020638
FGF23
fibroblast growth factor 23
chr2_+_38893051 0.025 NM_138801
GALM
galactose mutarotase (aldose 1-epimerase)
chr14_+_51955854 0.023 NM_001042481
FRMD6
FERM domain containing 6
chr3_+_45017749 0.018 EXOSC7
exosome component 7
chr7_-_87342569 0.018 NM_000927
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr4_-_24981769 0.017 NM_173463
CCDC149
coiled-coil domain containing 149
chr6_+_149887542 0.017 C6orf72
chromosome 6 open reading frame 72
chr3_+_45017729 0.016 NM_015004
EXOSC7
exosome component 7
chr6_+_144612872 0.016 NM_007124
UTRN
utrophin
chr6_-_62995852 0.014 NM_152688
KHDRBS2
KH domain containing, RNA binding, signal transduction associated 2
chr21_+_31768294 0.014 NM_181599
KRTAP13-1
keratin associated protein 13-1
chr8_+_92261515 0.014 NM_052832
NM_134266
SLC26A7

solute carrier family 26, member 7

chr12_-_11214892 0.013 NM_176887
TAS2R46
taste receptor, type 2, member 46
chr9_+_141106636 0.008 NM_001145249
FAM157B
family with sequence similarity 157, member B
chr6_-_131291480 0.008 NM_001199389
EPB41L2
erythrocyte membrane protein band 4.1-like 2
chrX_-_76814217 0.005 ATRX
alpha thalassemia/mental retardation syndrome X-linked
chr3_-_167191808 0.005 NM_006217
SERPINI2
serpin peptidase inhibitor, clade I (pancpin), member 2
chrX_+_49091931 0.004 CCDC22
coiled-coil domain containing 22
chr2_+_38893238 0.003 GALM
galactose mutarotase (aldose 1-epimerase)
chr21_-_31538970 0.002 NM_012131
CLDN17
claudin 17
chr1_+_84874033 0.001 NM_058248
DNASE2B
deoxyribonuclease II beta

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.