Motif ID: PAX2.p2

Z-value: 1.660


Transcription factors associated with PAX2.p2:

Gene SymbolEntrez IDGene Name
PAX2 5076 paired box 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PAX2hg19_v1_chr10_+_102505337_102505467-0.123.1e-01Click!


Activity profile for motif PAX2.p2.

activity profile for motif PAX2.p2


Sorted Z-values histogram for motif PAX2.p2

Sorted Z-values for motif PAX2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PAX2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_+_52445185 18.422 NM_002135
NM_173157
NR4A1

nuclear receptor subfamily 4, group A, member 1

chr5_+_172483285 17.298 NM_001168393
NM_001168394
NM_153607
C5orf41


chromosome 5 open reading frame 41


chrX_-_106960028 16.413 TSC22D3
TSC22 domain family, member 3
chr20_+_33146500 15.625 NM_032514
MAP1LC3A
microtubule-associated protein 1 light chain 3 alpha
chrX_-_106960268 12.588 NM_004089
TSC22D3
TSC22 domain family, member 3
chr20_-_44519629 10.992 NM_080749
NEURL2
neuralized homolog 2 (Drosophila)
chr17_-_42200957 10.942 HDAC5
histone deacetylase 5
chr17_-_42201009 10.828 NM_001015053
NM_005474
HDAC5

histone deacetylase 5

chrX_+_102631408 10.799 NGFRAP1
nerve growth factor receptor (TNFRSF16) associated protein 1
chr1_-_11866079 10.265 NM_005957
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chrX_+_102631267 8.733 NM_206915
NM_206917
NGFRAP1

nerve growth factor receptor (TNFRSF16) associated protein 1

chr14_-_64970319 8.573 NM_006977
ZBTB25
zinc finger and BTB domain containing 25
chr15_-_40401041 8.470 NM_001003940
BMF
Bcl2 modifying factor
chr11_+_18720342 8.288 NM_153347
TMEM86A
transmembrane protein 86A
chr10_-_64576074 8.277 EGR2
early growth response 2
chr10_-_64576123 8.126 NM_000399
NM_001136177
NM_001136179
EGR2


early growth response 2


chr1_-_11865963 8.090 MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr13_-_110438896 7.782 NM_003749
IRS2
insulin receptor substrate 2
chr1_-_186649421 7.673 NM_000963
PTGS2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
chr6_+_89791510 7.600 PNRC1
proline-rich nuclear receptor coactivator 1
chr1_-_156265395 7.561 NM_144580
C1orf85
chromosome 1 open reading frame 85
chr11_-_119252364 7.147 NM_001243759
NM_004205
USP2

ubiquitin specific peptidase 2

chr20_-_48099178 7.072 NM_004975
KCNB1
potassium voltage-gated channel, Shab-related subfamily, member 1
chr1_-_156265457 6.952 C1orf85
chromosome 1 open reading frame 85
chr5_+_137801178 6.913 NM_001964
EGR1
early growth response 1
chrX_-_107019001 6.899 NM_198057
TSC22D3
TSC22 domain family, member 3
chr5_+_137801166 6.872 EGR1
early growth response 1
chr6_-_109330752 6.814 NM_001199933
SESN1
sestrin 1
chr3_-_36986535 6.561 NM_014831
TRANK1
tetratricopeptide repeat and ankyrin repeat containing 1
chr3_+_44903376 6.533 NM_144638
TMEM42
transmembrane protein 42
chr14_-_24898730 6.505 NM_001039771
CBLN3
cerebellin 3 precursor
chr6_+_138188352 6.390 NM_006290
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr12_-_91572328 6.352 NM_133504
NM_133505
NM_133506
NM_133507
DCN



decorin



chr3_-_187463474 6.307 NM_001706
BCL6
B-cell CLL/lymphoma 6
chr2_+_237478379 6.201 NM_020311
CXCR7
chemokine (C-X-C motif) receptor 7
chr1_+_212781969 6.183 NM_001040619
NM_001206484
NM_001206488
NM_001674
ATF3



activating transcription factor 3



chr6_+_43027368 6.168 NM_138343
NM_201521
KLC4

kinesin light chain 4

chr15_-_40398573 6.077 NM_033503
BMF
Bcl2 modifying factor
chr10_+_23728197 5.874 NM_001145373
OTUD1
OTU domain containing 1
chr2_-_216300444 5.802 FN1
fibronectin 1
chr1_+_11866302 5.788 CLCN6
chloride channel 6
chr1_+_11866240 5.766 CLCN6
chloride channel 6
chr6_+_89790464 5.731 PNRC1
proline-rich nuclear receptor coactivator 1
chr17_-_47841517 5.684 NM_030802
FAM117A
family with sequence similarity 117, member A
chr11_+_18720281 5.672 TMEM86A
transmembrane protein 86A
chr12_+_57998600 5.545 NM_178502
DTX3
deltex homolog 3 (Drosophila)
chr13_-_33002218 5.523 NM_001079691
NM_052818
N4BP2L1

NEDD4 binding protein 2-like 1

chr19_-_36545646 5.465 NM_152658
THAP8
THAP domain containing 8
chr6_-_134496833 5.436 SGK1
serum/glucocorticoid regulated kinase 1
chr6_+_89790412 5.330 NM_006813
PNRC1
proline-rich nuclear receptor coactivator 1
chr3_-_187463227 5.198 BCL6
B-cell CLL/lymphoma 6
chr1_+_212782103 5.157 ATF3
activating transcription factor 3
chr2_-_216300770 5.073 NM_002026
NM_054034
NM_212474
NM_212476
NM_212478
NM_212482
FN1





fibronectin 1





chr1_+_11866206 5.016 NM_001286
NM_021735
NM_021736
NM_021737
CLCN6



chloride channel 6



chr6_-_18122850 4.994 NM_198586
NHLRC1
NHL repeat containing 1
chr1_+_32712817 4.899 NM_032648
FAM167B
family with sequence similarity 167, member B
chr5_-_1112106 4.877 NM_006598
SLC12A7
solute carrier family 12 (potassium/chloride transporters), member 7
chr7_-_29186072 4.854 NM_019029
NM_031311
CPVL

carboxypeptidase, vitellogenic-like

chr3_+_23987514 4.783 NM_001145425
NR1D2
nuclear receptor subfamily 1, group D, member 2
chr13_+_88324777 4.747 NM_015567
SLITRK5
SLIT and NTRK-like family, member 5
chr19_-_47734215 4.715 NM_014417
BBC3
BCL2 binding component 3
chr2_+_74781846 4.700 DOK1
docking protein 1, 62kDa (downstream of tyrosine kinase 1)
chr6_-_84937313 4.651 NM_014895
KIAA1009
KIAA1009
chr17_-_7137580 4.623 DVL2
dishevelled, dsh homolog 2 (Drosophila)
chr17_-_7137722 4.552 NM_004422
DVL2
dishevelled, dsh homolog 2 (Drosophila)
chr8_-_22550708 4.551 NM_004430
EGR3
early growth response 3
chr12_-_64616032 4.520 NM_152440
C12orf66
chromosome 12 open reading frame 66
chr11_+_7618416 4.475 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr17_-_47841468 4.466 FAM117A
family with sequence similarity 117, member A
chr1_+_201476283 4.431


chr11_-_82782883 4.408 NM_014488
RAB30
RAB30, member RAS oncogene family
chr12_-_91573264 4.407 NM_133503
DCN
decorin
chr3_+_112280871 4.378 NM_017945
SLC35A5
solute carrier family 35, member A5
chr21_-_43187265 4.376 RIPK4
receptor-interacting serine-threonine kinase 4
chr11_-_18343670 4.370 NM_007216
NM_181507
NM_181508
HPS5


Hermansky-Pudlak syndrome 5


chr21_-_43187197 4.363 NM_020639
RIPK4
receptor-interacting serine-threonine kinase 4
chr11_-_119252267 4.330 USP2
ubiquitin specific peptidase 2
chr3_+_112280911 4.319 SLC35A5
solute carrier family 35, member A5
chr11_+_27528376 4.275 BDNF-AS1
BDNF antisense RNA 1 (non-protein coding)
chr6_-_109330682 4.216 SESN1
sestrin 1
chr3_+_52444514 4.176 NM_016483
NM_173341
PHF7

PHD finger protein 7

chr6_+_139456240 4.121 NM_016217
HECA
headcase homolog (Drosophila)
chr2_-_60780404 4.113 NM_018014
NM_022893
NM_138559
BCL11A


B-cell CLL/lymphoma 11A (zinc finger protein)


chrX_-_9733916 4.098 NM_000273
GPR143
G protein-coupled receptor 143
chrX_+_101975641 4.057 NM_001142524
NM_001142525
NM_001142526
NM_001142527
NM_001142528
NM_030639
BHLHB9





basic helix-loop-helix domain containing, class B, 9





chr15_+_72410630 4.029 NM_001172111
NM_145204
SENP8

SUMO/sentrin specific peptidase family member 8

chr19_+_19174792 4.024 NM_178526
SLC25A42
solute carrier family 25, member 42
chr5_-_80597362 3.966 LOC100131067
uncharacterized LOC100131067
chr2_-_211035377 3.942 C2orf67
chromosome 2 open reading frame 67
chr12_+_10365415 3.936 NM_031412
GABARAPL1
GABA(A) receptor-associated protein like 1
chr14_-_23388380 3.906 NM_001077351
NM_001077352
NM_018107
RBM23


RNA binding motif protein 23


chr10_-_17271955 3.888


chr12_-_7245006 3.858 NM_001733
C1R
complement component 1, r subcomponent
chr1_+_85527992 3.856 NM_145172
WDR63
WD repeat domain 63
chr1_-_45805606 3.854 NM_001048174
NM_001048172
NM_001048173
NM_001048171
NM_001128425
NM_012222
MUTYH





mutY homolog (E. coli)





chr17_-_7137675 3.852 DVL2
dishevelled, dsh homolog 2 (Drosophila)
chr10_+_17271859 3.844 VIM
vimentin
chr12_+_14956505 3.841 NM_175874
C12orf60
chromosome 12 open reading frame 60
chr7_+_27225009 3.823 HOXA11-AS1
HOXA11 antisense RNA 1 (non-protein coding)
chr12_-_56727720 3.809 NM_001166279
NM_014871
PAN2

PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)

chr8_-_71581419 3.806 NM_016027
LACTB2
lactamase, beta 2
chr12_+_54410641 3.776 NM_014620
NM_153693
HOXC4
HOXC6
homeobox C4
homeobox C6
chr3_+_69985750 3.760 NM_000248
NM_001184968
NM_198158
NM_198178
MITF



microphthalmia-associated transcription factor



chr10_+_76586299 3.737 NM_012330
KAT6B
K(lysine) acetyltransferase 6B
chr19_-_36545119 3.731 THAP8
THAP domain containing 8
chr1_-_202896315 3.725 KLHL12
kelch-like 12 (Drosophila)
chr19_-_40324747 3.711 NM_004714
NM_006483
NM_006484
DYRK1B


dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B


chr10_-_3827205 3.699 KLF6
Kruppel-like factor 6
chr14_+_64682671 3.699 NM_182910
SYNE2
spectrin repeat containing, nuclear envelope 2
chr5_-_154230212 3.685 NM_032385
C5orf4
chromosome 5 open reading frame 4
chr3_+_113616317 3.682 NM_001172105
GRAMD1C
GRAM domain containing 1C
chr8_-_95961543 3.661 NM_001135733
NM_033285
TP53INP1

tumor protein p53 inducible nuclear protein 1

chr10_+_17271277 3.655 VIM
vimentin
chr13_-_41768392 3.655 KBTBD7
kelch repeat and BTB (POZ) domain containing 7
chr10_+_17271276 3.644 VIM
vimentin
chr14_-_35873823 3.641 NM_020529
NFKBIA
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
chr10_-_123357503 3.596 NM_000141
NM_001144917
NM_001144918
NM_001144919
NM_022970
FGFR2




fibroblast growth factor receptor 2




chr1_+_154298034 3.593 NM_001005855
ATP8B2
ATPase, class I, type 8B, member 2
chr3_-_49459870 3.589 AMT
aminomethyltransferase
chr16_-_30107492 3.574 NM_031477
NM_001145524
YPEL3

yippee-like 3 (Drosophila)

chr2_+_220042901 3.543 NM_024293
FAM134A
family with sequence similarity 134, member A
chr1_+_154298026 3.537 ATP8B2
ATPase, class I, type 8B, member 2
chr6_-_46138584 3.508 NM_021572
ENPP5
ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)
chr10_+_17271302 3.481 VIM
vimentin
chr5_-_72861208 3.476 ANKRA2
ankyrin repeat, family A (RFXANK-like), 2
chr6_-_137540544 3.474 IFNGR1
interferon gamma receptor 1
chr19_-_41256349 3.468 C19orf54
chromosome 19 open reading frame 54
chr5_+_139927182 3.455 NM_003732
EIF4EBP3
eukaryotic translation initiation factor 4E binding protein 3
chr17_+_4046941 3.448 CYB5D2
cytochrome b5 domain containing 2
chr2_+_220042963 3.441 FAM134A
family with sequence similarity 134, member A
chr15_+_45722762 3.418 NM_032413
NM_197955
C15orf48

chromosome 15 open reading frame 48

chr2_-_175712276 3.411 NM_001206602
CHN1
chimerin (chimaerin) 1
chr19_-_41256371 3.410 C19orf54
chromosome 19 open reading frame 54
chr1_-_182360181 3.403 GLUL
glutamate-ammonia ligase
chr3_+_23986735 3.393 NM_005126
NR1D2
nuclear receptor subfamily 1, group D, member 2
chr5_-_139944045 3.381 NM_006051
NM_133172
NM_133173
NM_133174
APBB3



amyloid beta (A4) precursor protein-binding, family B, member 3



chr4_-_113558120 3.378 NM_018392
C4orf21
chromosome 4 open reading frame 21
chr10_+_17271341 3.367 VIM
vimentin
chr15_+_72410724 3.354 SENP8
SUMO/sentrin specific peptidase family member 8
chr2_+_219745243 3.344 NM_025216
WNT10A
wingless-type MMTV integration site family, member 10A
chr19_+_37407230 3.333 NM_001204835
NM_001204836
NM_001204837
NM_001204838
NM_001204839
NM_198539
ZNF568





zinc finger protein 568





chr12_+_12938540 3.322 NM_030817
APOLD1
apolipoprotein L domain containing 1
chr6_+_43027628 3.318 NM_201523
KLC4
kinesin light chain 4
chr12_-_7245048 3.318 C1R
complement component 1, r subcomponent
chr4_-_175204617 3.316 FBXO8
F-box protein 8
chr11_+_7535213 3.315 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr10_-_90967048 3.282 NM_003956
CH25H
cholesterol 25-hydroxylase
chr6_-_10694837 3.248 NM_001145020
C6orf52
chromosome 6 open reading frame 52
chr1_+_222886058 3.243 BROX
BRO1 domain and CAAX motif containing
chr10_-_64578926 3.225 NM_001136178
EGR2
early growth response 2
chr22_-_50970542 3.222 ODF3B
outer dense fiber of sperm tails 3B
chr3_-_50605062 3.216 NM_001171740
NM_001171743
NM_016210
C3orf18


chromosome 3 open reading frame 18


chr6_-_137540551 3.206 NM_000416
IFNGR1
interferon gamma receptor 1
chr14_-_23388294 3.205 RBM23
RNA binding motif protein 23
chr1_+_222885895 3.186 NM_144695
BROX
BRO1 domain and CAAX motif containing
chr5_-_39203061 3.185 FYB
FYN binding protein
chr8_-_22550456 3.185 EGR3
early growth response 3
chr12_+_49741040 3.180 NM_024902
DNAJC22
DnaJ (Hsp40) homolog, subfamily C, member 22
chr2_+_30454396 3.176 NM_030915
LBH
limb bud and heart development homolog (mouse)
chr15_-_40987284 3.172 LOC100505648
uncharacterized LOC100505648
chr11_-_82782870 3.171 RAB30
RAB30, member RAS oncogene family
chr3_-_126076057 3.143 NM_014079
KLF15
Kruppel-like factor 15
chr3_-_98241357 3.131 CLDND1
claudin domain containing 1
chr11_-_108338227 3.121 NM_152587
C11orf65
chromosome 11 open reading frame 65
chr10_+_17271956 3.104 VIM
vimentin
chr4_-_113558021 3.102 C4orf21
chromosome 4 open reading frame 21
chr4_-_186697065 3.095 NM_001145673
SORBS2
sorbin and SH3 domain containing 2
chr2_+_220042986 3.082 FAM134A
family with sequence similarity 134, member A
chr17_-_67138013 3.071 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr14_+_24584009 3.064 DCAF11
DDB1 and CUL4 associated factor 11
chr10_-_3827418 3.055 NM_001160124
NM_001160125
NM_001300
KLF6


Kruppel-like factor 6


chr14_-_23388359 3.047 RBM23
RNA binding motif protein 23
chrX_-_107018889 3.047 TSC22D3
TSC22 domain family, member 3
chr6_-_31648140 3.046 NM_025262
LY6G5C
lymphocyte antigen 6 complex, locus G5C
chr1_-_202896368 3.042 NM_021633
KLHL12
kelch-like 12 (Drosophila)
chr17_-_19770988 3.041 NM_001142610
NM_014683
ULK2

unc-51-like kinase 2 (C. elegans)

chr21_-_43816123 3.028 NM_024022
NM_032405
TMPRSS3

transmembrane protease, serine 3

chr14_+_24584321 3.028 DCAF11
DDB1 and CUL4 associated factor 11
chr11_-_105948464 2.969 NM_152433
NM_198439
KBTBD3

kelch repeat and BTB (POZ) domain containing 3

chrX_-_48814758 2.966 OTUD5
OTU domain containing 5
chr1_-_85358851 2.962 NM_012152
LPAR3
lysophosphatidic acid receptor 3
chr18_+_55711890 2.959 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr22_+_38201300 2.945 H1F0
H1 histone family, member 0
chr9_-_99801365 2.943 NM_001333
CTSL2
cathepsin L2
chr1_+_205197031 2.934 NM_014858
TMCC2
transmembrane and coiled-coil domain family 2
chr11_+_67776016 2.922 NM_001161473
ALDH3B1
aldehyde dehydrogenase 3 family, member B1
chr22_-_38577692 2.917 NM_001004426
NM_003560
NM_001199562
PLA2G6


phospholipase A2, group VI (cytosolic, calcium-independent)


chr17_+_47866061 2.917 KAT7
K(lysine) acetyltransferase 7
chr19_+_14544100 2.909 NM_002741
PKN1
protein kinase N1
chr1_+_181002560 2.906 NM_001194999
NM_001195000
NM_001195035
NM_001531
MR1



major histocompatibility complex, class I-related



chr11_-_113746205 2.903 NM_020886
USP28
ubiquitin specific peptidase 28
chr17_+_47866119 2.892 KAT7
K(lysine) acetyltransferase 7
chr17_+_40688264 2.888 NAGLU
N-acetylglucosaminidase, alpha
chr3_-_139396773 2.880 NM_001200047
NM_178177
NMNAT3

nicotinamide nucleotide adenylyltransferase 3

chr15_-_34629941 2.873 NM_001042494
NM_001042496
SLC12A6

solute carrier family 12 (potassium/chloride transporters), member 6

chr6_+_123110345 2.873 SMPDL3A
sphingomyelin phosphodiesterase, acid-like 3A
chr9_-_98279246 2.871 NM_001083602
NM_001083603
PTCH1

patched 1

chrX_+_105937067 2.871 NM_024539
RNF128
ring finger protein 128
chr14_+_24584467 2.869 NM_181357
DCAF11
DDB1 and CUL4 associated factor 11
chr20_+_44519590 2.868 NM_000308
NM_001127695
NM_001167594
CTSA


cathepsin A



Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
3.40 4.94e-04 GO:0005774 vacuolar membrane
2.55 5.36e-04 GO:0005773 vacuole
3.25 1.02e-03 GO:0044437 vacuolar part
3.56 2.99e-03 GO:0005765 lysosomal membrane
2.43 1.21e-02 GO:0000323 lytic vacuole
2.43 1.21e-02 GO:0005764 lysosome

Nothing significant found in function category.