Motif ID: NR5A1,2.p2

Z-value: 1.820


Transcription factors associated with NR5A1,2.p2:

Gene SymbolEntrez IDGene Name
NR5A1 2516 nuclear receptor subfamily 5, group A, member 1
NR5A2 2494 nuclear receptor subfamily 5, group A, member 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NR5A2hg19_v1_chr1_+_199996729_199997010-0.234.4e-02Click!
NR5A1hg19_v1_chr9_-_127269689_1272697190.217.6e-02Click!


Activity profile for motif NR5A1,2.p2.

activity profile for motif NR5A1,2.p2


Sorted Z-values histogram for motif NR5A1,2.p2

Sorted Z-values for motif NR5A1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR5A1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_119234628 12.725 USP2
ubiquitin specific peptidase 2
chr1_-_29309092 12.686


chr6_-_27782517 8.458 NM_021066
HIST1H2AJ
histone cluster 1, H2aj
chr4_-_57522469 8.344 NM_001145459
NM_139211
HOPX

HOP homeobox

chr2_+_241375207 7.505 GPC1
glypican 1
chr4_-_189026401 7.221 NM_173553
TRIML2
tripartite motif family-like 2
chr15_-_76352068 7.008 NRG4
neuregulin 4
chr7_+_43152196 6.899 NM_015052
HECW1
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
chr10_+_101542460 6.679 NM_000392
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr22_+_31518923 6.625 NM_001002837
INPP5J
inositol polyphosphate-5-phosphatase J
chr6_-_26199439 6.553 NM_021065
NM_003530
HIST1H2AD
HIST1H3D
histone cluster 1, H2ad
histone cluster 1, H3d
chr2_-_175869910 6.485 NM_001822
NM_001025201
CHN1

chimerin (chimaerin) 1

chr5_-_11903964 6.483 NM_001332
CTNND2
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
chr17_-_48266572 6.482 COL1A1
collagen, type I, alpha 1
chr17_-_48266313 6.476 COL1A1
collagen, type I, alpha 1
chr1_-_32827843 6.432 NM_001167676
LOC100128071
uncharacterized LOC100128071
chr11_+_1860718 6.418 NM_001145829
TNNI2
troponin I type 2 (skeletal, fast)
chr19_+_2249112 6.395 NM_000479
AMH
anti-Mullerian hormone
chr12_-_123201319 6.256 NM_006018
HCAR3
hydroxycarboxylic acid receptor 3
chr4_-_57522059 6.215 HOPX
HOP homeobox
chrX_-_130964633 6.162 LOC286467
family with sequence similarity 195, member A pseudogene
chr22_+_21321446 6.021 NM_001146288
AIFM3
apoptosis-inducing factor, mitochondrion-associated, 3
chr10_+_101542554 5.737 ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr12_-_123187842 5.732 NM_177551
HCAR2
hydroxycarboxylic acid receptor 2
chr2_-_230933618 5.658 NM_152527
SLC16A14
solute carrier family 16, member 14 (monocarboxylic acid transporter 14)
chr4_+_189060597 5.629 NM_178556
TRIML1
tripartite motif family-like 1
chr17_-_46035109 5.558 NM_024320
PRR15L
proline rich 15-like
chr10_-_21786186 5.502 C10orf114
chromosome 10 open reading frame 114
chr4_+_41614911 5.431 NM_001112719
NM_001112720
LIMCH1

LIM and calponin homology domains 1

chr10_-_21786205 5.410 NM_001010911
C10orf114
chromosome 10 open reading frame 114
chr17_-_48271968 5.401


chr1_-_151798552 5.233 NM_001001523
RORC
RAR-related orphan receptor C
chr1_+_18807423 5.200 NM_152375
KLHDC7A
kelch domain containing 7A
chr4_+_41614933 5.124 LIMCH1
LIM and calponin homology domains 1
chr19_+_55851220 5.116 NM_032701
SUV420H2
suppressor of variegation 4-20 homolog 2 (Drosophila)
chr11_-_119234859 5.073 NM_171997
USP2
ubiquitin specific peptidase 2
chr16_+_2198607 5.056 NM_014353
RAB26
RAB26, member RAS oncogene family
chr12_-_53074172 5.053 NM_006121
KRT1
keratin 1
chr12_-_13248581 5.011 NM_001206843
NM_001206845
NM_031289
NM_153823
GSG1



germ cell associated 1



chr8_+_143761873 4.879 NM_005672
PSCA
prostate stem cell antigen
chr17_-_39661803 4.845 NM_002274
NM_153490
KRT13

keratin 13

chr11_-_63330854 4.826 NM_017878
HRASLS2
HRAS-like suppressor 2
chr19_-_49558996 4.653 NM_033142
CGB7
chorionic gonadotropin, beta polypeptide 7
chr4_+_41614725 4.637 LIMCH1
LIM and calponin homology domains 1
chr3_-_49460110 4.496 NM_000481
NM_001164710
NM_001164711
NM_001164712
AMT



aminomethyltransferase



chr19_-_42569921 4.494 NM_002088
GRIK5
glutamate receptor, ionotropic, kainate 5
chr3_-_187454247 4.363 NM_001130845
BCL6
B-cell CLL/lymphoma 6
chr19_-_49016418 4.310 NM_001080434
LMTK3
lemur tyrosine kinase 3
chr12_-_11422640 4.296 NM_006249
PRB3
proline-rich protein BstNI subfamily 3
chrX_-_15620191 4.294 NM_021804
ACE2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr6_-_24877453 4.266 NM_015864
FAM65B
family with sequence similarity 65, member B
chr16_-_67223998 4.263 NM_178516
EXOC3L1
exocyst complex component 3-like 1
chr11_+_61248584 4.257 NM_001170753
NM_145017
PPP1R32

protein phosphatase 1, regulatory subunit 32

chr17_-_74533623 4.141 NM_134268
CYGB
cytoglobin
chr4_-_185726865 4.114 ACSL1
acyl-CoA synthetase long-chain family member 1
chr2_+_28718937 4.046 NM_001170585
NM_153021
PLB1

phospholipase B1

chr1_+_32827797 3.983 NM_052841
TSSK3
testis-specific serine kinase 3
chr1_-_12677347 3.975 NM_004753
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr2_+_233243243 3.975 NM_001632
ALPP
alkaline phosphatase, placental
chr1_-_204459445 3.952 NM_002646
PIK3C2B
phosphoinositide-3-kinase, class 2, beta polypeptide
chr17_-_48265912 3.951 COL1A1
collagen, type I, alpha 1
chr16_+_2198687 3.943 RAB26
RAB26, member RAS oncogene family
chr2_-_32490688 3.896 NM_001199139
NM_021209
NLRC4

NLR family, CARD domain containing 4

chr19_-_55973048 3.884 NM_001136201
NM_001136202
NM_024710
ISOC2


isochorismatase domain containing 2


chr6_+_27833033 3.856 NM_003511
HIST1H2AI
HIST1H2AL
histone cluster 1, H2ai
histone cluster 1, H2al
chr16_-_28608367 3.854 NM_001054
SULT1A2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr8_+_145149985 3.816 CYC1
cytochrome c-1
chr5_+_32710742 3.767 NM_001204376
NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr17_-_34079896 3.738 NM_139285
GAS2L2
growth arrest-specific 2 like 2
chr14_+_93389491 3.691 CHGA
chromogranin A (parathyroid secretory protein 1)
chr3_+_54156691 3.654 NM_018398
CACNA2D3
calcium channel, voltage-dependent, alpha 2/delta subunit 3
chr9_+_135937364 3.643 NM_001807
CEL
carboxyl ester lipase (bile salt-stimulated lipase)
chr1_+_9415944 3.613


chr18_+_44497512 3.591 KATNAL2
katanin p60 subunit A-like 2
chr5_+_176875325 3.577 NM_001174102
PRR7
proline rich 7 (synaptic)
chr5_+_159656436 3.575 NM_001445
FABP6
fatty acid binding protein 6, ileal
chr8_-_124553253 3.529 FBXO32
F-box protein 32
chr4_-_2420252 3.521 NM_001172656
NM_001172657
NM_001172658
NM_020972
ZFYVE28



zinc finger, FYVE domain containing 28



chrX_-_112084006 3.514 NM_133265
AMOT
angiomotin
chr15_-_40398286 3.457 NM_001003942
NM_001003943
BMF

Bcl2 modifying factor

chr10_-_75634219 3.449 NM_001204492
NM_001222
NM_172169
NM_172170
NM_172171
NM_172173
CAMK2G





calcium/calmodulin-dependent protein kinase II gamma





chr16_+_691901 3.403 FAM195A
family with sequence similarity 195, member A
chr22_+_22676814 3.360


chr11_-_16424391 3.309 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr14_+_62462540 3.303 NM_031914
SYT16
synaptotagmin XVI
chr19_-_47735858 3.258 NM_001127240
NM_001127241
NM_001127242
BBC3


BCL2 binding component 3


chr11_+_63304272 3.253 NM_004585
RARRES3
retinoic acid receptor responder (tazarotene induced) 3
chr5_-_11904127 3.220 CTNND2
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
chr16_+_67001377 3.217 NM_001185176
CES3
carboxylesterase 3
chr1_+_162351519 3.215 NM_001085375
C1orf226
chromosome 1 open reading frame 226
chr19_+_50304801 3.183


chr2_+_74741565 3.171 NM_016170
TLX2
T-cell leukemia homeobox 2
chr6_+_35704858 3.168 NM_145028
C6orf81
chromosome 6 open reading frame 81
chr19_-_39322411 3.150 NM_001398
ECH1
enoyl CoA hydratase 1, peroxisomal
chr14_-_102975996 3.074 ANKRD9
ankyrin repeat domain 9
chr8_+_144349564 3.062 NM_138465
GLI4
GLI family zinc finger 4
chr18_-_44336991 3.055 NM_013305
ST8SIA5
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
chr4_-_40517913 3.016 NM_019027
RBM47
RNA binding motif protein 47
chr1_-_108507474 3.014 NM_006113
VAV3
vav 3 guanine nucleotide exchange factor
chr17_-_36762105 3.011 NM_025248
SRCIN1
SRC kinase signaling inhibitor 1
chr3_+_54156573 3.001 CACNA2D3
calcium channel, voltage-dependent, alpha 2/delta subunit 3
chr22_+_41865112 2.998 NM_001098
ACO2
aconitase 2, mitochondrial
chr1_+_212738675 2.986 NM_001030287
ATF3
activating transcription factor 3
chr19_-_17356022 2.980 NM_005234
NR2F6
nuclear receptor subfamily 2, group F, member 6
chr12_+_57849086 2.972 NM_031479
INHBE
inhibin, beta E
chr8_-_145752405 2.962 NM_001024678
LRRC24
leucine rich repeat containing 24
chr2_+_219646704 2.949 CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1
chr11_+_65658101 2.949 CCDC85B
coiled-coil domain containing 85B
chr16_+_57481336 2.930 NM_020312
COQ9
coenzyme Q9 homolog (S. cerevisiae)
chr19_-_47734215 2.927 NM_014417
BBC3
BCL2 binding component 3
chr8_+_145149978 2.922 CYC1
cytochrome c-1
chr2_+_98262497 2.913 NM_001862
COX5B
cytochrome c oxidase subunit Vb
chr3_+_160394946 2.876 NM_025047
ARL14
ADP-ribosylation factor-like 14
chr22_+_50354428 2.864 PIM3
pim-3 oncogene
chr10_+_99344421 2.861 HOGA1
4-hydroxy-2-oxoglutarate aldolase 1
chr3_-_49459870 2.795 AMT
aminomethyltransferase
chr4_-_149357954 2.790


chr12_+_13154435 2.787 HTR7P1
5-hydroxytryptamine (serotonin) receptor 7 pseudogene 1
chr19_+_2328679 2.783 SPPL2B
signal peptide peptidase-like 2B
chr7_-_27187367 2.779 NM_024014
HOXA6
homeobox A6
chr6_-_27806116 2.762 NM_003510
HIST1H2AK
histone cluster 1, H2ak
chr17_-_45899133 2.760 NM_145798
OSBPL7
oxysterol binding protein-like 7
chr13_+_31287614 2.746 NM_001204406
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr11_+_69061599 2.745 NM_138768
MYEOV
myeloma overexpressed (in a subset of t(11;14) positive multiple myelomas)
chr17_-_48271365 2.744


chr10_+_70847857 2.738 SRGN
serglycin
chr9_+_37650996 2.732 NM_014907
FRMPD1
FERM and PDZ domain containing 1
chr17_+_48545689 2.722 ACSF2
acyl-CoA synthetase family member 2
chr10_-_101190201 2.710 NM_002079
GOT1
glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)
chr16_-_66952729 2.687 NM_001204744
NM_001204745
NM_001204746
NM_004062
CDH16



cadherin 16, KSP-cadherin



chr6_+_152128453 2.684 NM_001122740
ESR1
estrogen receptor 1
chr19_+_54965628 2.683


chr7_+_94536926 2.674 NM_001166160
NM_017650
PPP1R9A

protein phosphatase 1, regulatory subunit 9A

chr8_+_145149936 2.671 NM_001916
CYC1
cytochrome c-1
chr7_-_64451413 2.665 NM_015852
ZNF117
zinc finger protein 117
chr7_+_150688143 2.658 NM_000603
NOS3
nitric oxide synthase 3 (endothelial cell)
chr12_+_13153337 2.640 HTR7P1
5-hydroxytryptamine (serotonin) receptor 7 pseudogene 1
chr3_-_187871816 2.637 LPP-AS2
LPP antisense RNA 2 (non-protein coding)
chr22_+_18043147 2.626 NM_031481
SLC25A18
solute carrier family 25 (mitochondrial carrier), member 18
chr15_+_63050761 2.609 TLN2
talin 2
chr17_-_37381920 2.588 NM_198993
STAC2
SH3 and cysteine rich domain 2
chr19_+_2328628 2.570 NM_001077238
NM_152988
SPPL2B

signal peptide peptidase-like 2B

chrX_-_112066353 2.567 NM_001113490
AMOT
angiomotin
chr17_-_73505914 2.564 NM_001142643
CASKIN2
CASK interacting protein 2
chr7_+_128312345 2.559 NM_001012454
NM_001128926
FAM71F2

family with sequence similarity 71, member F2

chr2_-_202222066 2.555 NM_001127391
NM_139163
ALS2CR12

amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 12

chr17_-_48546174 2.544 NM_001267
CHAD
chondroadherin
chr10_+_26727651 2.536 APBB1IP
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr6_+_26199712 2.530 NM_003522
HIST1H2BF
histone cluster 1, H2bf
chr6_+_152128685 2.524 NM_000125
ESR1
estrogen receptor 1
chr17_-_1553099 2.522 NM_031430
RILP
Rab interacting lysosomal protein
chr19_+_11350282 2.513 NM_018687
C19orf80
chromosome 19 open reading frame 80
chr16_-_28621279 2.505 NM_001055
NM_177529
SULT1A1

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

chr16_-_4665002 2.492 FAM100A
family with sequence similarity 100, member A
chr1_-_26147256 2.489 LOC646471
uncharacterized LOC646471
chr1_+_15764934 2.488 NM_007272
CTRC
chymotrypsin C (caldecrin)
chr16_+_776957 2.476 NM_032304
HAGHL
hydroxyacylglutathione hydrolase-like
chr8_-_108510094 2.474 NM_001146
NM_001199859
ANGPT1

angiopoietin 1

chr19_+_49468656 2.472 FTL
ferritin, light polypeptide
chr1_+_6094342 2.470 NM_001199860
KCNAB2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
chr12_-_106532447 2.468 NUAK1
NUAK family, SNF1-like kinase, 1
chrX_-_65835845 2.465 NM_001242310
EDA2R
ectodysplasin A2 receptor
chr4_+_86749045 2.465 ARHGAP24
Rho GTPase activating protein 24
chr4_-_40631846 2.457 NM_001098634
RBM47
RNA binding motif protein 47
chr5_-_160279045 2.447 NM_025153
ATP10B
ATPase, class V, type 10B
chr5_+_172068188 2.446 NM_001142651
NEURL1B
neuralized homolog 1B (Drosophila)
chr7_+_141478241 2.426 NM_016944
TAS2R4
taste receptor, type 2, member 4
chr17_+_48049678 2.401 DLX4
distal-less homeobox 4
chr19_+_2328685 2.385 SPPL2B
signal peptide peptidase-like 2B
chr17_-_45899118 2.374 OSBPL7
oxysterol binding protein-like 7
chr6_-_41130921 2.362 NM_018965
TREM2
triggering receptor expressed on myeloid cells 2
chr11_-_8190535 2.353 NM_001135109
NM_001206671
NM_001206672
NM_024557
RIC3



resistance to inhibitors of cholinesterase 3 homolog (C. elegans)



chr1_-_59248287 2.348 JUN
jun proto-oncogene
chr5_+_145317297 2.347 SH3RF2
SH3 domain containing ring finger 2
chr13_-_114103452 2.342 NM_199162
ADPRHL1
ADP-ribosylhydrolase like 1
chr6_-_11232883 2.334 NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr6_-_11232900 2.332 NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr10_-_94050799 2.327 NM_014912
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr6_-_27860927 2.318 NM_003514
HIST1H2AM
histone cluster 1, H2am
chr15_-_40401041 2.313 NM_001003940
BMF
Bcl2 modifying factor
chr1_-_155178968 2.302 THBS3
thrombospondin 3
chr6_-_11232901 2.299 NM_006403
NM_182966
NEDD9

neural precursor cell expressed, developmentally down-regulated 9

chr6_-_27775683 2.299 NM_003519
HIST1H2BL
histone cluster 1, H2bl
chr14_+_78266419 2.288 NM_001142545
NM_020421
ADCK1

aarF domain containing kinase 1

chr20_+_43803539 2.278 NM_002638
PI3
peptidase inhibitor 3, skin-derived
chr14_-_102976096 2.278 NM_152326
ANKRD9
ankyrin repeat domain 9
chr2_+_111878450 2.277 NM_001204106
NM_001204107
NM_001204108
NM_001204109
NM_001204110
NM_001204111
NM_001204112
NM_001204113
NM_006538
NM_138621
NM_138622
NM_138623
NM_138624
NM_138625
NM_138626
NM_138627
NM_207002
NM_207003
BCL2L11

















BCL2-like 11 (apoptosis facilitator)

















chr2_+_233320832 2.275 NM_001631
ALPI
alkaline phosphatase, intestinal
chr19_+_6372720 2.270 ALKBH7
alkB, alkylation repair homolog 7 (E. coli)
chr16_-_54319966 2.268 IRX3
iroquois homeobox 3
chr3_+_160473995 2.255 NM_139245
PPM1L
protein phosphatase, Mg2+/Mn2+ dependent, 1L
chr22_+_37257004 2.247 NM_000631
NM_013416
NCF4

neutrophil cytosolic factor 4, 40kDa

chr19_+_6372805 2.244 ALKBH7
alkB, alkylation repair homolog 7 (E. coli)
chr22_+_32010152 2.237 SFI1
Sfi1 homolog, spindle assembly associated (yeast)
chr2_-_192711651 2.234 SDPR
serum deprivation response
chr7_+_2443205 2.231 CHST12
carbohydrate (chondroitin 4) sulfotransferase 12
chr10_-_76995685 2.225 NM_144589
COMTD1
catechol-O-methyltransferase domain containing 1
chr17_-_39093671 2.224 NM_015515
KRT23
keratin 23 (histone deacetylase inducible)
chr3_-_73673978 2.221 NM_015009
PDZRN3
PDZ domain containing ring finger 3
chr6_-_30899926 2.217 NM_205854
SFTA2
surfactant associated 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
2.97 4.26e-05 GO:0006091 generation of precursor metabolites and energy
1.66 2.26e-04 GO:0065008 regulation of biological quality
2.11 3.60e-04 GO:0055114 oxidation-reduction process
4.22 1.51e-03 GO:0022900 electron transport chain
4.77 3.96e-03 GO:0006334 nucleosome assembly
4.77 3.96e-03 GO:0022904 respiratory electron transport chain
4.15 4.07e-03 GO:0045333 cellular respiration
4.53 7.24e-03 GO:0031497 chromatin assembly
2.76 8.79e-03 GO:0032787 monocarboxylic acid metabolic process
4.31 1.27e-02 GO:0034728 nucleosome organization
1.88 1.78e-02 GO:0006629 lipid metabolic process
4.14 1.95e-02 GO:0065004 protein-DNA complex assembly
2.77 3.15e-02 GO:0015980 energy derivation by oxidation of organic compounds
3.92 3.56e-02 GO:0071824 protein-DNA complex subunit organization
2.98 4.71e-02 GO:0048514 blood vessel morphogenesis

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
7.32 3.29e-06 GO:0000786 nucleosome
4.98 1.49e-04 GO:0032993 protein-DNA complex
2.30 3.53e-03 GO:0005740 mitochondrial envelope
2.33 4.05e-03 GO:0031966 mitochondrial membrane
2.61 5.27e-03 GO:0005743 mitochondrial inner membrane
2.39 2.03e-02 GO:0019866 organelle inner membrane
1.61 2.93e-02 GO:0005739 mitochondrion
2.65 3.45e-02 GO:0000785 chromatin

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
2.17 3.47e-04 GO:0016491 oxidoreductase activity
5.96 5.31e-03 GO:0003707 steroid hormone receptor activity
5.63 8.59e-03 GO:0004879 ligand-dependent nuclear receptor activity