Motif ID: NR4A2.p2

Z-value: 1.556


Transcription factors associated with NR4A2.p2:

monomer

Gene SymbolEntrez IDGene Name
NR4A2 4929 nuclear receptor subfamily 4, group A, member 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NR4A2hg19_v1_chr2_-_157186681_1571867000.113.3e-01Click!


Activity profile for motif NR4A2.p2.

activity profile for motif NR4A2.p2


Sorted Z-values histogram for motif NR4A2.p2

Sorted Z-values for motif NR4A2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR4A2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_+_43344005 18.483 WISP2
WNT1 inducible signaling pathway protein 2
chr17_-_39661803 18.182 NM_002274
NM_153490
KRT13

keratin 13

chr20_+_43343884 10.816 NM_003881
WISP2
WNT1 inducible signaling pathway protein 2
chr14_-_23288912 8.970 NM_001126106
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr10_+_101542554 8.482 ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr5_+_133842276 8.263


chr15_-_76352068 7.888 NRG4
neuregulin 4
chr10_+_101542460 7.649 NM_000392
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr19_+_6772705 7.100 NM_005428
VAV1
vav 1 guanine nucleotide exchange factor
chr11_+_69061599 6.648 NM_138768
MYEOV
myeloma overexpressed (in a subset of t(11;14) positive multiple myelomas)
chr11_-_119234628 6.598 USP2
ubiquitin specific peptidase 2
chr4_+_41614911 6.495 NM_001112719
NM_001112720
LIMCH1

LIM and calponin homology domains 1

chr4_+_41614933 6.386 LIMCH1
LIM and calponin homology domains 1
chr19_+_1776117 6.264


chr10_+_123872440 6.190 TACC2
transforming, acidic coiled-coil containing protein 2
chr4_+_41614725 6.127 LIMCH1
LIM and calponin homology domains 1
chr12_-_53600999 6.080 NM_000889
ITGB7
integrin, beta 7
chr1_+_212738675 6.008 NM_001030287
ATF3
activating transcription factor 3
chr12_-_53601051 5.987 ITGB7
integrin, beta 7
chr20_+_43343523 5.938 WISP2
WNT1 inducible signaling pathway protein 2
chr15_-_74494851 5.879 STRA6
stimulated by retinoic acid gene 6 homolog (mouse)
chr7_-_99381703 5.773 NM_001202855
NM_017460
CYP3A4

cytochrome P450, family 3, subfamily A, polypeptide 4

chr22_+_31518923 5.582 NM_001002837
INPP5J
inositol polyphosphate-5-phosphatase J
chr1_-_29309092 5.421


chr20_-_61002588 5.393 NM_080833
C20orf151
chromosome 20 open reading frame 151
chr3_-_196065191 5.390 TM4SF19
transmembrane 4 L six family member 19
chr15_-_74494780 5.372 STRA6
stimulated by retinoic acid gene 6 homolog (mouse)
chr11_+_1860718 5.267 NM_001145829
TNNI2
troponin I type 2 (skeletal, fast)
chr18_+_44497512 5.263 KATNAL2
katanin p60 subunit A-like 2
chr10_-_103535656 5.260 NM_006119
NM_033163
NM_033164
NM_033165
FGF8



fibroblast growth factor 8 (androgen-induced)



chr2_+_233271551 5.103 NM_031313
ALPPL2
alkaline phosphatase, placental-like 2
chr1_+_160085519 4.924 NM_000702
ATP1A2
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr9_+_37650996 4.801 NM_014907
FRMPD1
FERM and PDZ domain containing 1
chr4_-_39033981 4.739 NM_024943
TMEM156
transmembrane protein 156
chr6_-_33714681 4.712 NM_001142883
NM_054111
IP6K3

inositol hexakisphosphate kinase 3

chr20_-_23030141 4.665 NM_000361
THBD
thrombomodulin
chr14_-_107211131 4.654 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr1_-_151804225 4.624 NM_005060
RORC
RAR-related orphan receptor C
chr1_-_53238341 4.599


chr19_-_6375859 4.588 NM_004158
PSPN
persephin
chr2_+_234621637 4.573 NM_019078
UGT1A5
UDP glucuronosyltransferase 1 family, polypeptide A5
chr6_-_24489738 4.511 NM_177483
NM_001503
GPLD1

glycosylphosphatidylinositol specific phospholipase D1

chr1_+_9415944 4.489


chr22_+_35779103 4.461 HMOX1
heme oxygenase (decycling) 1
chr10_-_49482912 4.320 NM_001018071
FRMPD2
FERM and PDZ domain containing 2
chr13_+_43136871 4.248 NM_033012
TNFSF11
tumor necrosis factor (ligand) superfamily, member 11
chr1_+_26348265 4.247 NM_004455
EXTL1
exostoses (multiple)-like 1
chr10_+_124030820 4.128 NM_144587
BTBD16
BTB (POZ) domain containing 16
chr2_+_103236147 4.026 NM_003048
SLC9A2
solute carrier family 9 (sodium/hydrogen exchanger), member 2
chr19_-_55574434 3.961 NM_001145971
RDH13
retinol dehydrogenase 13 (all-trans/9-cis)
chr19_+_56159400 3.913 CCDC106
coiled-coil domain containing 106
chr2_+_85980600 3.869 NM_032827
ATOH8
atonal homolog 8 (Drosophila)
chr11_+_116700620 3.865 NM_000040
APOC3
apolipoprotein C-III
chr8_-_108510094 3.859 NM_001146
NM_001199859
ANGPT1

angiopoietin 1

chr2_+_234637772 3.826 NM_019093
UGT1A3
UDP glucuronosyltransferase 1 family, polypeptide A3
chr3_-_196065243 3.780 NM_001204897
NM_001204898
NM_138461
TM4SF19


transmembrane 4 L six family member 19


chr19_+_54606141 3.765 NM_004542
NDUFA3
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
chr7_+_128312345 3.755 NM_001012454
NM_001128926
FAM71F2

family with sequence similarity 71, member F2

chr19_-_46146984 3.682 NM_001193269
EML2
echinoderm microtubule associated protein like 2
chr7_+_141478241 3.663 NM_016944
TAS2R4
taste receptor, type 2, member 4
chr19_-_41255827 3.606 NM_198476
C19orf54
chromosome 19 open reading frame 54
chr22_+_50354428 3.573 PIM3
pim-3 oncogene
chr2_+_234627423 3.554 NM_007120
UGT1A4
UDP glucuronosyltransferase 1 family, polypeptide A4
chr2_+_228678556 3.466 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr16_-_3306586 3.388 NM_000243
NM_001198536
MEFV

Mediterranean fever

chr8_+_145149985 3.323 CYC1
cytochrome c-1
chr7_+_94536926 3.320 NM_001166160
NM_017650
PPP1R9A

protein phosphatase 1, regulatory subunit 9A

chr12_-_772525 3.267 NM_016533
NINJ2
ninjurin 2
chr11_+_47270433 3.255 NM_001130102
NR1H3
nuclear receptor subfamily 1, group H, member 3
chr12_-_11422640 3.239 NM_006249
PRB3
proline-rich protein BstNI subfamily 3
chr17_+_77893155 3.216


chr3_+_54156691 3.141 NM_018398
CACNA2D3
calcium channel, voltage-dependent, alpha 2/delta subunit 3
chr14_-_64749530 3.133 NM_001214902
NM_001214903
ESR2

estrogen receptor 2 (ER beta)

chr1_+_47264669 3.126 NM_000779
NM_001099772
CYP4B1

cytochrome P450, family 4, subfamily B, polypeptide 1

chr19_-_49016418 3.097 NM_001080434
LMTK3
lemur tyrosine kinase 3
chr17_-_79623561 3.034 NM_002602
PDE6G
phosphodiesterase 6G, cGMP-specific, rod, gamma
chr17_-_39211462 3.014 NM_033032
KRTAP2-2
keratin associated protein 2-2
chr20_+_43803539 2.977 NM_002638
PI3
peptidase inhibitor 3, skin-derived
chr1_-_109849613 2.917 NM_001010985
MYBPHL
myosin binding protein H-like
chr21_-_15918635 2.873 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr19_+_49929687 2.865 NM_001195256
LOC100507003
uncharacterized LOC100507003
chr3_+_54156573 2.850 CACNA2D3
calcium channel, voltage-dependent, alpha 2/delta subunit 3
chr19_-_41256349 2.838 C19orf54
chromosome 19 open reading frame 54
chr18_-_67615088 2.831 CD226
CD226 molecule
chr13_+_53602829 2.803 NM_006418
OLFM4
olfactomedin 4
chr17_+_48610045 2.770 NM_017957
EPN3
epsin 3
chr6_-_11382501 2.755 NM_001142393
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr19_+_3708358 2.754 TJP3
tight junction protein 3 (zona occludens 3)
chr11_+_20044362 2.742 NAV2
neuron navigator 2
chr16_-_69760444 2.729 NM_000903
NM_001025433
NM_001025434
NQO1


NAD(P)H dehydrogenase, quinone 1


chr17_+_4692226 2.727 NM_001014985
GLTPD2
glycolipid transfer protein domain containing 2
chr9_-_112970412 2.682 NM_001012993
C9orf152
chromosome 9 open reading frame 152
chr19_-_41256371 2.662 C19orf54
chromosome 19 open reading frame 54
chr13_+_31309690 2.604 ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr14_-_65409445 2.569 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr12_-_6484557 2.545 SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chrX_-_47489243 2.533 NM_001145252
CFP
complement factor properdin
chr18_+_11981457 2.526 IMPA2
inositol(myo)-1(or 4)-monophosphatase 2
chr15_-_75017710 2.522 NM_000499
CYP1A1
cytochrome P450, family 1, subfamily A, polypeptide 1
chr16_-_69760354 2.505 NQO1
NAD(P)H dehydrogenase, quinone 1
chr1_-_205912546 2.501 NM_052934
NM_134325
SLC26A9

solute carrier family 26, member 9

chr11_-_6462129 2.486 NM_000613
HPX
hemopexin
chr2_+_11886739 2.473 NM_145693
LPIN1
lipin 1
chr11_-_73720281 2.472 NM_003356
NM_022803
UCP3

uncoupling protein 3 (mitochondrial, proton carrier)

chr17_-_39203423 2.471 NM_001123387
KRTAP2-1
keratin associated protein 2-1
chr19_+_54376975 2.467 MYADM
myeloid-associated differentiation marker
chr2_-_188419049 2.442 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr19_+_42817434 2.436 NM_173633
TMEM145
transmembrane protein 145
chr4_-_159094163 2.429 NM_001031700
NM_001128424
FAM198B

family with sequence similarity 198, member B

chr1_-_151798552 2.409 NM_001001523
RORC
RAR-related orphan receptor C
chr3_+_47029453 2.388 NBEAL2
neurobeachin-like 2
chr12_-_45307710 2.381 NM_001145110
NELL2
NEL-like 2 (chicken)
chr19_-_4517715 2.375 NM_001080400
PLIN4
perilipin 4
chr11_-_66139064 2.374 NM_001532
SLC29A2
solute carrier family 29 (nucleoside transporters), member 2
chr16_+_70207927 2.362 NM_173619
CLEC18C
CLEC18A
C-type lectin domain family 18, member C
C-type lectin domain family 18, member A
chr17_-_39222126 2.346 NM_033184
KRTAP2-4
keratin associated protein 2-4
chr3_+_186435097 2.342 NM_000893
NM_001102416
NM_001166451
KNG1


kininogen 1


chr2_-_175869910 2.341 NM_001822
NM_001025201
CHN1

chimerin (chimaerin) 1

chr2_-_190927321 2.336 NM_005259
MSTN
myostatin
chr7_+_76751933 2.314 NM_020879
CCDC146
coiled-coil domain containing 146
chr19_+_45251933 2.304 NM_005178
BCL3
B-cell CLL/lymphoma 3
chr16_-_69760367 2.304 NQO1
NAD(P)H dehydrogenase, quinone 1
chr17_-_1553099 2.271 NM_031430
RILP
Rab interacting lysosomal protein
chr5_-_126409171 2.269 NM_001164478
NM_001164479
C5orf63

chromosome 5 open reading frame 63

chr1_+_27668499 2.266 SYTL1
synaptotagmin-like 1
chr5_+_175969511 2.252 NM_001171976
CDHR2
cadherin-related family member 2
chr10_-_75634219 2.243 NM_001204492
NM_001222
NM_172169
NM_172170
NM_172171
NM_172173
CAMK2G





calcium/calmodulin-dependent protein kinase II gamma





chr17_-_46035109 2.219 NM_024320
PRR15L
proline rich 15-like
chr19_-_45579687 2.217 NM_145288
ZNF296
zinc finger protein 296
chr17_+_48046561 2.199 NM_138281
DLX4
distal-less homeobox 4
chr5_-_176937337 2.198 NM_001144875
NM_001144876
DOK3

docking protein 3

chr19_-_56739658 2.191 NM_024303
ZSCAN5A
zinc finger and SCAN domain containing 5A
chr16_+_72088507 2.187 NM_001126102
NM_005143
HP

haptoglobin

chr14_+_100150596 2.185 NM_006668
CYP46A1
cytochrome P450, family 46, subfamily A, polypeptide 1
chr12_-_16759531 2.165 NM_018640
LMO3
LIM domain only 3 (rhombotin-like 2)
chr12_+_119616594 2.152 NM_014365
HSPB8
heat shock 22kDa protein 8
chr9_+_135937364 2.149 NM_001807
CEL
carboxyl ester lipase (bile salt-stimulated lipase)
chr19_-_46285645 2.138 DMPK
dystrophia myotonica-protein kinase
chr19_-_56135931 2.131 ZNF784
zinc finger protein 784
chr8_+_143761873 2.129 NM_005672
PSCA
prostate stem cell antigen
chr1_+_16062808 2.119 NM_207348
SLC25A34
solute carrier family 25, member 34
chr16_+_67001377 2.102 NM_001185176
CES3
carboxylesterase 3
chr16_+_72097124 2.100 NM_020995
HPR
haptoglobin-related protein
chr1_+_81771844 2.086 LPHN2
latrophilin 2
chr19_+_10397642 2.084 NM_001039132
NM_001544
NM_022377
ICAM4


intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)


chr12_-_6484389 2.082 NM_001159576
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr19_+_49838673 2.059 NM_001040031
NM_001774
CD37

CD37 molecule

chr10_+_70980058 2.047 NM_025130
HKDC1
hexokinase domain containing 1
chr15_+_58430394 2.044 NM_020980
AQP9
aquaporin 9
chr12_-_16759420 2.040 LMO3
LIM domain only 3 (rhombotin-like 2)
chr10_+_17794250 2.038 NM_001098844
TMEM236
transmembrane protein 236
chr10_-_94050799 2.037 NM_014912
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr11_+_86748870 2.034 NM_001168724
NM_022918
TMEM135

transmembrane protein 135

chr10_-_91295310 2.030 NM_213606
SLC16A12
solute carrier family 16, member 12 (monocarboxylic acid transporter 12)
chr10_+_114154522 2.028 ACSL5
acyl-CoA synthetase long-chain family member 5
chr1_+_27668462 2.026 NM_001193308
NM_032872
SYTL1

synaptotagmin-like 1

chr17_-_36762105 2.016 NM_025248
SRCIN1
SRC kinase signaling inhibitor 1
chr9_-_71629009 1.997 NM_002732
PRKACG
protein kinase, cAMP-dependent, catalytic, gamma
chr16_+_680931 1.991 NM_053284
WFIKKN1
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
chr3_-_46718898 1.989 NM_182775
ALS2CL
ALS2 C-terminal like
chr19_-_49176263 1.983 NM_145807
NTN5
netrin 5
chr11_+_1860232 1.973 NM_003282
TNNI2
troponin I type 2 (skeletal, fast)
chr19_+_49838646 1.973 CD37
CD37 molecule
chr17_+_48610077 1.971 EPN3
epsin 3
chr10_-_5060191 1.971 NM_001354
NM_205845
AKR1C2

aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)

chr4_-_139163222 1.957 NM_014331
SLC7A11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr19_+_2328679 1.947 SPPL2B
signal peptide peptidase-like 2B
chr11_-_47470687 1.942 NM_005055
NM_032645
RAPSN

receptor-associated protein of the synapse

chr10_-_14879967 1.935 NM_001029954
CDNF
cerebral dopamine neurotrophic factor
chr10_+_105344714 1.920 NEURL
neuralized homolog (Drosophila)
chr2_+_171034654 1.903 NM_001083615
NM_001171642
NM_138995
MYO3B


myosin IIIB


chr9_+_139846767 1.898 NM_178536
LCN12
lipocalin 12
chr10_+_103986142 1.897 NM_152310
ELOVL3
ELOVL fatty acid elongase 3
chr1_-_204183036 1.892 NM_198447
GOLT1A
golgi transport 1A
chr19_-_11689765 1.891 NM_001111035
NM_001111036
ACP5

acid phosphatase 5, tartrate resistant

chr12_-_21757752 1.890 NM_021957
GYS2
glycogen synthase 2 (liver)
chr9_+_139839697 1.885 NM_000606
C8G
complement component 8, gamma polypeptide
chr12_-_86230158 1.880 NM_005447
RASSF9
Ras association (RalGDS/AF-6) domain family (N-terminal) member 9
chr17_+_78075299 1.865 NM_000152
NM_001079803
NM_001079804
GAA


glucosidase, alpha; acid


chr16_+_88519917 1.865 NM_153813
ZFPM1
zinc finger protein, multitype 1
chr10_+_99349354 1.862 NM_001009997
C10orf62
chromosome 10 open reading frame 62
chr17_+_79679370 1.856 NM_012140
SLC25A10
solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
chr16_-_72206023 1.853 NM_031293
PMFBP1
polyamine modulated factor 1 binding protein 1
chr16_+_2961994 1.850 FLYWCH1
FLYWCH-type zinc finger 1
chr11_-_10715503 1.850 NM_001100163
NM_001206880
NM_001206881
NM_130385
MRVI1



murine retrovirus integration site 1 homolog



chr15_-_65715385 1.843 NM_020962
IGDCC4
immunoglobulin superfamily, DCC subclass, member 4
chr8_+_145729464 1.835 NM_005309
GPT
glutamic-pyruvate transaminase (alanine aminotransferase)
chr19_+_49838700 1.832 CD37
CD37 molecule
chr8_+_145149978 1.826 CYC1
cytochrome c-1
chr19_+_54371150 1.818 MYADM
myeloid-associated differentiation marker
chr2_-_188419185 1.802 NM_001032281
NM_006287
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chr20_+_39969420 1.802 NM_022896
LPIN3
lipin 3
chr16_+_70502824 1.799 FUK
fucokinase
chr7_+_99971132 1.796 PILRA
paired immunoglobin-like type 2 receptor alpha
chr19_-_39322411 1.792 NM_001398
ECH1
enoyl CoA hydratase 1, peroxisomal
chr1_-_161193190 1.792 APOA2
apolipoprotein A-II
chr19_+_54371170 1.789 MYADM
myeloid-associated differentiation marker
chr5_+_159343739 1.781 NM_000679
ADRA1B
adrenergic, alpha-1B-, receptor
chr15_+_67000929 1.767 NM_001142861
SMAD6
SMAD family member 6
chrX_-_108868250 1.767 NM_012282
KCNE1L
KCNE1-like

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.70 2.84e-03 GO:0065008 regulation of biological quality
2.32 1.07e-02 GO:0044255 cellular lipid metabolic process
2.06 1.27e-02 GO:0006629 lipid metabolic process
3.27 3.02e-02 GO:0008202 steroid metabolic process
5.83 3.23e-02 GO:0019748 secondary metabolic process
2.01 4.61e-02 GO:0055114 oxidation-reduction process

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
3.24 3.05e-03 GO:0005792 microsome
3.13 4.80e-03 GO:0042598 vesicular fraction
1.92 3.50e-02 GO:0005626 insoluble fraction
1.22 3.97e-02 GO:0016020 membrane

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
1.82 1.41e-02 GO:0005215 transporter activity
1.90 3.10e-02 GO:0022857 transmembrane transporter activity
3.93 4.25e-02 GO:0008194 UDP-glycosyltransferase activity