Motif ID: NKX6-1,2.p2

Z-value: 1.123


Transcription factors associated with NKX6-1,2.p2:

Gene SymbolEntrez IDGene Name
NKX6-1 4825 NK6 homeobox 1
NKX6-2 84504 NK6 homeobox 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NKX6-1hg19_v1_chr4_-_85419386_85419386-0.243.5e-02Click!
NKX6-2hg19_v1_chr10_-_134599477_1345995360.161.8e-01Click!


Activity profile for motif NKX6-1,2.p2.

activity profile for motif NKX6-1,2.p2


Sorted Z-values histogram for motif NKX6-1,2.p2

Sorted Z-values for motif NKX6-1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX6-1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_28124915 16.561 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr1_-_110933635 11.205 SLC16A4
solute carrier family 16, member 4 (monocarboxylic acid transporter 5)
chr2_-_73520448 9.971 NM_001965
EGR4
early growth response 4
chr15_+_25068793 9.522 NM_022806
NM_022807
NM_022808
SNRPN


small nuclear ribonucleoprotein polypeptide N


chr5_+_147582338 9.319 NM_001195290
NM_205841
SPINK6

serine peptidase inhibitor, Kazal type 6

chr4_+_41258909 8.633 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr3_-_74570262 8.465 NM_020872
CNTN3
contactin 3 (plasmacytoma associated)
chr6_+_136172802 8.215 NM_018945
PDE7B
phosphodiesterase 7B
chr4_+_41258895 8.043 NM_004181
UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr3_-_64211111 7.929 NM_198859
PRICKLE2
prickle homolog 2 (Drosophila)
chr8_-_82395401 7.445 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr8_-_7212868 7.369 FAM66B
family with sequence similarity 66, member B
chr2_-_161056573 6.848 NM_000888
ITGB6
integrin, beta 6
chr4_+_71384289 6.794 NM_212557
AMTN
amelotin
chr1_-_150738292 6.784 NM_001199739
NM_004079
CTSS

cathepsin S

chr4_+_41258941 6.527 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr19_-_35981345 6.252 NM_001244847
NM_207392
KRTDAP

keratinocyte differentiation-associated protein

chr12_+_9980076 6.149 NM_016523
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chr1_-_221915393 6.105 DUSP10
dual specificity phosphatase 10
chr1_-_221915426 5.545 DUSP10
dual specificity phosphatase 10
chr4_-_186733372 5.379 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr2_+_202047803 5.347 CASP10
caspase 10, apoptosis-related cysteine peptidase
chr2_+_132285469 5.154 NM_138770
CCDC74A
coiled-coil domain containing 74A
chr4_-_186732047 5.014 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr1_-_221915458 5.011 NM_007207
NM_144729
DUSP10

dual specificity phosphatase 10

chrX_+_105937067 5.011 NM_024539
RNF128
ring finger protein 128
chr2_-_161056762 4.917 ITGB6
integrin, beta 6
chr10_+_90484300 4.853 NM_001080518
LIPK
lipase, family member K
chr1_-_150738232 4.794 CTSS
cathepsin S
chr1_-_109399705 4.497 NM_152763
AKNAD1
AKNA domain containing 1
chr5_+_145316120 4.486 NM_152550
SH3RF2
SH3 domain containing ring finger 2
chr8_+_79428335 4.377 NM_006823
NM_181839
PKIA

protein kinase (cAMP-dependent, catalytic) inhibitor alpha

chr1_-_150738255 4.375 CTSS
cathepsin S
chr4_-_110723127 4.189 CFI
complement factor I
chr1_+_152730505 4.171 NM_001025231
KPRP
keratinocyte proline-rich protein
chr2_-_238322840 4.128 NM_004369
NM_057164
NM_057165
NM_057166
NM_057167
COL6A3




collagen, type VI, alpha 3




chr8_-_22549901 4.072 NM_001199880
EGR3
early growth response 3
chr5_+_140566655 3.952 NM_019119
PCDHB9
protocadherin beta 9
chr5_+_140613937 3.760 PCDHB18
protocadherin beta 18 pseudogene
chr7_+_23286420 3.693 GPNMB
glycoprotein (transmembrane) nmb
chr13_+_53602829 3.680 NM_006418
OLFM4
olfactomedin 4
chr20_+_51801821 3.671 NM_001193421
TSHZ2
teashirt zinc finger homeobox 2
chr8_-_23712297 3.638 NM_003155
STC1
stanniocalcin 1
chr18_+_28898051 3.574 NM_001942
DSG1
desmoglein 1
chr7_+_23286401 3.480 GPNMB
glycoprotein (transmembrane) nmb
chr12_+_7023490 3.436 NM_001975
ENO2
enolase 2 (gamma, neuronal)
chr1_+_209878135 3.360 NM_005525
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr5_+_59784004 3.324 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chrX_+_102631267 3.318 NM_206915
NM_206917
NGFRAP1

nerve growth factor receptor (TNFRSF16) associated protein 1

chr8_-_22550057 3.195 NM_001199881
EGR3
early growth response 3
chr19_+_15160194 3.096 NM_012114
CASP14
caspase 14, apoptosis-related cysteine peptidase
chr7_+_23286384 3.074 GPNMB
glycoprotein (transmembrane) nmb
chr3_+_132036210 3.050 NM_001099
NM_001134194
ACPP

acid phosphatase, prostate

chr17_+_72581056 2.906 NM_152460
C17orf77
chromosome 17 open reading frame 77
chr5_-_111091947 2.893 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr2_+_218990735 2.866 NM_001557
CXCR2
chemokine (C-X-C motif) receptor 2
chr10_-_90611675 2.842 NM_144590
ANKRD22
ankyrin repeat domain 22
chr13_-_36429798 2.744 NM_001195415
NM_001195416
NM_001195430
DCLK1


doublecortin-like kinase 1


chr7_+_28725597 2.728 NM_001011666
CREB5
cAMP responsive element binding protein 5
chr4_-_110723334 2.723 NM_000204
CFI
complement factor I
chr9_+_82186846 2.702 NM_007005
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr7_+_23286386 2.639 GPNMB
glycoprotein (transmembrane) nmb
chr1_-_32281577 2.636 NM_144569
SPOCD1
SPOC domain containing 1
chr7_-_20256942 2.632 NM_182762
MACC1
metastasis associated in colon cancer 1
chr1_+_204913353 2.625 NM_001160331
NFASC
neurofascin
chr4_+_74606222 2.601 NM_000584
IL8
interleukin 8
chr2_-_225811730 2.560 DOCK10
dedicator of cytokinesis 10
chr11_+_94277005 2.550 NM_002033
PIWIL4
FUT4
piwi-like 4 (Drosophila)
fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
chr7_+_23286390 2.534 GPNMB
glycoprotein (transmembrane) nmb
chr4_-_186877413 2.395 SORBS2
sorbin and SH3 domain containing 2
chr13_-_45048436 2.332 NM_001243798
TSC22D1
TSC22 domain family, member 1
chr1_-_156265395 2.303 NM_144580
C1orf85
chromosome 1 open reading frame 85
chr5_-_64777703 2.302 NM_197941
ADAMTS6
ADAM metallopeptidase with thrombospondin type 1 motif, 6
chr15_+_80733579 2.300 ARNT2
aryl-hydrocarbon receptor nuclear translocator 2
chr3_+_132036276 2.221 ACPP
acid phosphatase, prostate
chr7_+_23286277 2.156 NM_001005340
NM_002510
GPNMB

glycoprotein (transmembrane) nmb

chr14_-_99737821 2.144 NM_022898
NM_138576
BCL11B

B-cell CLL/lymphoma 11B (zinc finger protein)

chrX_-_10535476 2.114 NM_001193278
NM_001193279
NM_001193280
NM_001193281
MID1



midline 1 (Opitz/BBB syndrome)



chrX_+_50027539 2.106 NM_033031
NM_033670
CCNB3

cyclin B3

chr1_-_160924530 2.087 NM_080878
ITLN2
intelectin 2
chr1_-_207095198 2.061 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr1_+_152956563 1.996 NM_001199828
NM_005987
SPRR1A

small proline-rich protein 1A

chr17_-_60885650 1.994 NM_152598
MARCH10
membrane-associated ring finger (C3HC4) 10
chr2_-_238322815 1.970 COL6A3
collagen, type VI, alpha 3
chr7_-_14025826 1.947 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr17_+_57915192 1.933


chr2_+_68961912 1.909 NM_001007231
NM_001166277
ARHGAP25

Rho GTPase activating protein 25

chr5_-_160279045 1.879 NM_025153
ATP10B
ATPase, class V, type 10B
chr4_-_122854192 1.868 NM_003305
TRPC3
transient receptor potential cation channel, subfamily C, member 3
chr17_-_39222126 1.867 NM_033184
KRTAP2-4
keratin associated protein 2-4
chr10_-_52008312 1.823 NM_001143974
NM_019893
ASAH2

N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2

chr5_+_140588267 1.789 NM_018932
PCDHB12
protocadherin beta 12
chr2_-_238322806 1.765 COL6A3
collagen, type VI, alpha 3
chr12_+_8332789 1.754 FAM66C
family with sequence similarity 66, member C
chr6_+_49518112 1.742 NM_001145652
C6orf141
chromosome 6 open reading frame 141
chr16_+_31271311 1.726 ITGAM
integrin, alpha M (complement component 3 receptor 3 subunit)
chr1_+_160370363 1.703 NM_020335
VANGL2
vang-like 2 (van gogh, Drosophila)
chr16_+_31271277 1.703 NM_000632
NM_001145808
ITGAM

integrin, alpha M (complement component 3 receptor 3 subunit)

chr15_+_25281105 1.698 SNRPN
small nuclear ribonucleoprotein polypeptide N
chr21_-_36421578 1.688 RUNX1
runt-related transcription factor 1
chr2_-_217559497 1.685 IGFBP5
insulin-like growth factor binding protein 5
chr19_+_41281281 1.673 NM_006533
MIA
melanoma inhibitory activity
chr18_+_61254533 1.661 NM_012397
SERPINB13
serpin peptidase inhibitor, clade B (ovalbumin), member 13
chr10_-_75682534 1.634 NM_001001791
C10orf55
chromosome 10 open reading frame 55
chr4_+_169418167 1.617 NM_001166108
NM_016081
PALLD

palladin, cytoskeletal associated protein

chr14_-_60097314 1.593 RTN1
reticulon 1
chr12_+_111284763 1.564 NM_152591
CCDC63
coiled-coil domain containing 63
chr1_-_116383323 1.561 NM_001111061
NHLH2
nescient helix loop helix 2
chrX_+_47441650 1.561 NM_003254
TIMP1
TIMP metallopeptidase inhibitor 1
chr10_+_90562486 1.504 NM_001128215
LIPM
lipase, family member M
chr3_-_172241060 1.477 NM_001190943
NM_001190942
NM_003810
TNFSF10


tumor necrosis factor (ligand) superfamily, member 10


chr1_+_74701070 1.466 NM_015978
TNNI3K
TNNI3 interacting kinase
chr2_-_238322814 1.466 COL6A3
collagen, type VI, alpha 3
chr9_-_136604894 1.453 NM_007101
SARDH
sarcosine dehydrogenase
chr8_-_22550708 1.436 NM_004430
EGR3
early growth response 3
chr9_+_82187469 1.433 TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr19_-_14910947 1.430 NM_198944
OR7C1
olfactory receptor, family 7, subfamily C, member 1
chr2_-_217560247 1.428 NM_000599
IGFBP5
insulin-like growth factor binding protein 5
chrX_+_47441802 1.418 TIMP1
TIMP metallopeptidase inhibitor 1
chr9_+_82187599 1.411 TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr6_-_56716412 1.409 DST
dystonin
chr3_+_194207685 1.378 FLJ34208
uncharacterized LOC401106
chr5_+_140174443 1.355 NM_018905
NM_031495
PCDHA2

protocadherin alpha 2

chr5_+_140729723 1.344 NM_018922
NM_032095
PCDHGB1

protocadherin gamma subfamily B, 1

chr7_+_80267782 1.338 NM_000072
NM_001001548
CD36

CD36 molecule (thrombospondin receptor)

chr9_-_28719302 1.322 NM_152570
LINGO2
leucine rich repeat and Ig domain containing 2
chr4_-_186877869 1.300 NM_021069
SORBS2
sorbin and SH3 domain containing 2
chr2_-_208030613 1.294 NM_003709
KLF7
Kruppel-like factor 7 (ubiquitous)
chr10_+_65224937 1.288 LOC84989
uncharacterized LOC84989
chr16_+_31271327 1.285 ITGAM
integrin, alpha M (complement component 3 receptor 3 subunit)
chr17_-_41836132 1.281 NM_025237
SOST
sclerostin
chr7_-_102283237 1.279 NM_001114403
UPK3BL
uroplakin 3B-like
chr6_+_26199712 1.278 NM_003522
HIST1H2BF
histone cluster 1, H2bf
chr4_+_74269971 1.274 NM_000477
ALB
albumin
chr1_+_161676761 1.254 NM_001184866
NM_001184867
NM_001184870
NM_001184871
NM_001184872
NM_001184873
NM_032738
FCRLA






Fc receptor-like A






chr1_+_12227050 1.251 NM_001066
TNFRSF1B
tumor necrosis factor receptor superfamily, member 1B
chr6_+_125304509 1.241 NM_152553
RNF217
ring finger protein 217
chr1_+_244624672 1.235 NM_001130957
NM_001242340
NM_173807
C1orf101


chromosome 1 open reading frame 101


chrX_-_114252132 1.233 NM_000640
IL13RA2
interleukin 13 receptor, alpha 2
chr11_-_71524890 1.218 LOC285407
asparagine-linked glycosylation 1 homolog pseudogene
chr2_+_218989997 1.199 NM_001168298
CXCR2
chemokine (C-X-C motif) receptor 2
chr4_-_90759446 1.192 NM_001146055
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr12_+_20963637 1.183 NM_019844
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr2_-_151344145 1.180 NM_005168
RND3
Rho family GTPase 3
chr10_+_74870209 1.164 NM_015901
NUDT13
nudix (nucleoside diphosphate linked moiety X)-type motif 13
chr1_+_210501595 1.162 NM_001122834
NM_001170564
HHAT

hedgehog acyltransferase

chr8_+_67344717 1.153 NM_144650
ADHFE1
alcohol dehydrogenase, iron containing, 1
chr5_+_140800536 1.152 NM_018914
NM_032091
NM_032092
PCDHGA11


protocadherin gamma subfamily A, 11


chr14_-_99737554 1.127 BCL11B
B-cell CLL/lymphoma 11B (zinc finger protein)
chr18_-_46477080 1.120 NM_001190821
NM_005904
SMAD7

SMAD family member 7

chr11_-_7727940 1.118 NM_198185
OVCH2
ovochymase 2 (gene/pseudogene)
chr6_-_26043884 1.103 NM_021062
HIST1H2BB
histone cluster 1, H2bb
chr12_+_25205488 1.095 LRMP
lymphoid-restricted membrane protein
chr5_+_140261792 1.095 NM_018904
NM_031865
PCDHA13

protocadherin alpha 13

chr17_-_38978824 1.088 NM_000421
KRT10
keratin 10
chr5_+_140739589 1.068 NM_018923
NM_032096
PCDHGB2

protocadherin gamma subfamily B, 2

chr6_-_37665631 1.050 NM_153487
MDGA1
MAM domain containing glycosylphosphatidylinositol anchor 1
chr21_-_36421195 1.043 RUNX1
runt-related transcription factor 1
chr6_-_46703429 1.042 NM_001168357
PLA2G7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr12_-_53600999 1.041 NM_000889
ITGB7
integrin, beta 7
chr5_-_95748688 1.022 NM_001177876
PCSK1
proprotein convertase subtilisin/kexin type 1
chr5_+_140571903 1.013 NM_018930
PCDHB10
protocadherin beta 10
chr15_+_36932805 1.009 NM_032499
C15orf41
chromosome 15 open reading frame 41
chr12_+_27397077 1.000 NM_015000
STK38L
serine/threonine kinase 38 like
chr11_+_65266980 0.974


chr5_+_140810126 0.967 NM_003735
NM_032094
PCDHGA12

protocadherin gamma subfamily A, 12

chr5_-_136834887 0.964 NM_004598
SPOCK1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
chr1_-_186430216 0.958 NM_002597
PDC
phosducin
chr10_-_28571014 0.956 NM_173496
MPP7
membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
chr11_+_7618416 0.955 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr17_+_56315786 0.954 NM_001160102
NM_006151
LPO

lactoperoxidase

chrX_+_41548225 0.931 NM_001097579
NM_005300
GPR34

G protein-coupled receptor 34

chr1_+_43253660 0.929 NM_001242750
LOC100129924
uncharacterized LOC100129924
chr13_+_97928414 0.929 MBNL2
muscleblind-like 2 (Drosophila)
chr5_+_140800613 0.926 PCDHGA11
protocadherin gamma subfamily A, 11
chr4_+_166299942 0.925 NM_001873
CPE
carboxypeptidase E
chr1_-_173020011 0.913 NM_005092
TNFSF18
tumor necrosis factor (ligand) superfamily, member 18
chr21_-_42219038 0.906 NM_001389
DSCAM
Down syndrome cell adhesion molecule
chr5_+_140480056 0.901 NM_018937
PCDHB3
protocadherin beta 3
chr5_+_140514787 0.900 NM_015669
PCDHB5
protocadherin beta 5
chr6_+_26225382 0.900 NM_003532
HIST1H3E
histone cluster 1, H3e
chr19_-_23598867 0.897


chr21_-_36421461 0.893 RUNX1
runt-related transcription factor 1
chr21_+_30517897 0.887 C21orf7
chromosome 21 open reading frame 7
chr20_+_42136313 0.884 NM_032107
L3MBTL1
l(3)mbt-like 1 (Drosophila)
chr3_-_21792815 0.882 NM_024697
ZNF385D
zinc finger protein 385D
chr2_+_228029280 0.880 NM_000091
COL4A3
collagen, type IV, alpha 3 (Goodpasture antigen)
chrX_-_10544852 0.877 NM_001193277
MID1
midline 1 (Opitz/BBB syndrome)
chr21_-_36421630 0.867 RUNX1
runt-related transcription factor 1
chr13_-_48987652 0.866 NM_001162498
LPAR6
lysophosphatidic acid receptor 6
chr17_-_4938699 0.859 NM_001104577
NM_017986
GPR172B

G protein-coupled receptor 172B

chr1_-_183559669 0.855 NM_000433
NM_001190789
NM_001190794
NCF2


neutrophil cytosolic factor 2


chr5_-_43040147 0.839 NM_001014279
C5orf39
chromosome 5 open reading frame 39
chr12_+_70861853 0.836


chr17_-_67057046 0.834 NM_080283
ABCA9
ATP-binding cassette, sub-family A (ABC1), member 9
chr8_-_110661007 0.828 NM_001099747
NM_001099748
NM_001099749
NM_001099750
NM_017786
SYBU




syntabulin (syntaxin-interacting)




chr14_-_61115906 0.826 NM_005982
SIX1
SIX homeobox 1
chr4_-_170077807 0.820 SH3RF1
SH3 domain containing ring finger 1
chr16_-_46782104 0.814 NM_182493
MYLK3
myosin light chain kinase 3
chr12_+_75784849 0.811 GLIPR1L2
GLI pathogenesis-related 1 like 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
4.57 1.12e-06 GO:0007155 cell adhesion
4.57 1.12e-06 GO:0022610 biological adhesion
10.84 1.58e-05 GO:0007156 homophilic cell adhesion
5.60 2.43e-03 GO:0016337 cell-cell adhesion
1.76 4.30e-02 GO:0032502 developmental process

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
2.31 6.72e-04 GO:0005576 extracellular region
2.79 5.28e-03 GO:0044421 extracellular region part
7.54 1.75e-02 GO:0044420 extracellular matrix part

Nothing significant found in function category.