Motif ID: NKX3-2.p2

Z-value: 0.988


Transcription factors associated with NKX3-2.p2:

Gene SymbolEntrez IDGene Name
NKX3-2 579 NK3 homeobox 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NKX3-2hg19_v1_chr4_-_13546037_135461130.047.1e-01Click!


Activity profile for motif NKX3-2.p2.

activity profile for motif NKX3-2.p2


Sorted Z-values histogram for motif NKX3-2.p2

Sorted Z-values for motif NKX3-2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX3-2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_110723127 10.793 CFI
complement factor I
chr4_+_41258941 10.482 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr5_+_52776479 8.789 FST
follistatin
chr1_+_152974222 8.441 NM_001097589
NM_005416
SPRR3

small proline-rich protein 3

chr17_-_46655544 7.478 NM_024015
HOXB4
homeobox B4
chr2_+_17721983 6.835 VSNL1
visinin-like 1
chr5_+_52776263 6.652 NM_006350
NM_013409
FST

follistatin

chr16_+_82660641 6.522 CDH13
cadherin 13, H-cadherin (heart)
chr16_+_82660573 6.488 CDH13
cadherin 13, H-cadherin (heart)
chr3_+_71803200 6.459 NM_018971
GPR27
G protein-coupled receptor 27
chr2_-_160919120 6.434 NM_001007267
NM_001195641
NM_007366
PLA2R1


phospholipase A2 receptor 1, 180kDa


chr3_+_121774208 6.396 NM_001206924
NM_001206925
NM_175862
CD86


CD86 molecule


chr17_+_60705051 6.337 MRC2
mannose receptor, C type 2
chr4_-_110723334 6.319 NM_000204
CFI
complement factor I
chr2_+_48807725 6.300 NM_001198594
STON1
STON1-GTF2A1L
stonin 1
STON1-GTF2A1L readthrough
chrX_-_64196268 6.268 NM_001178033
NM_018684
ZC4H2

zinc finger, C4H2 domain containing

chr4_+_41258909 6.018 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr7_-_83270746 5.923 NM_001178129
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr3_-_48632592 5.798 NM_000094
COL7A1
collagen, type VII, alpha 1
chr11_-_77734285 5.616 NM_023930
KCTD14
potassium channel tetramerisation domain containing 14
chr11_+_130318457 5.514 NM_139055
ADAMTS15
ADAM metallopeptidase with thrombospondin type 1 motif, 15
chr5_+_53751430 5.421 NM_006308
HSPB3
heat shock 27kDa protein 3
chrX_+_102631267 5.381 NM_206915
NM_206917
NGFRAP1

nerve growth factor receptor (TNFRSF16) associated protein 1

chr22_-_38966066 5.312 NM_007068
DMC1
DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast)
chr9_+_131870105 5.239


chr1_+_100111430 5.201 NM_017734
PALMD
palmdelphin
chr1_-_205391180 5.113 NM_001001552
NM_001199050
NM_001199051
NM_001199052
LEMD1



LEM domain containing 1



chr4_-_57976550 4.903 NM_001253835
NM_001553
IGFBP7

insulin-like growth factor binding protein 7

chr2_+_48757292 4.851 NM_001198595
NM_006873
STON1

stonin 1

chr5_-_151066492 4.811 NM_003118
SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chr14_-_21493122 4.806 NM_201538
NM_201539
NM_201540
NM_201541
NDRG2



NDRG family member 2



chr5_+_52776408 4.803 FST
follistatin
chr12_-_110271205 4.779 NM_021625
TRPV4
transient receptor potential cation channel, subfamily V, member 4
chr4_+_41258895 4.715 NM_004181
UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr1_-_32169555 4.714 COL16A1
collagen, type XVI, alpha 1
chrX_+_117629871 4.695 NM_144658
DOCK11
dedicator of cytokinesis 11
chrX_-_64254592 4.679 NM_001178032
NM_001243804
ZC4H2

zinc finger, C4H2 domain containing

chr4_-_57976516 4.674 IGFBP7
insulin-like growth factor binding protein 7
chr1_-_32169619 4.592 NM_001856
COL16A1
collagen, type XVI, alpha 1
chrX_+_134555867 4.552 LINC00086
long intergenic non-protein coding RNA 86
chr2_+_17721806 4.394 NM_003385
VSNL1
visinin-like 1
chr1_-_221915426 4.390 DUSP10
dual specificity phosphatase 10
chr17_+_60705042 4.384 MRC2
mannose receptor, C type 2
chr5_-_151066445 4.309 SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chr20_+_44098392 4.198 NM_006103
WFDC2
WAP four-disulfide core domain 2
chr1_-_146697155 4.175 NM_001144829
NM_001144830
NM_001461
FMO5


flavin containing monooxygenase 5


chr20_-_25038501 4.054 NM_001252675
NM_001252677
NM_032501
ACSS1


acyl-CoA synthetase short-chain family member 1


chrX_+_102631408 4.003 NGFRAP1
nerve growth factor receptor (TNFRSF16) associated protein 1
chr11_-_102401430 4.000 NM_002423
MMP7
matrix metallopeptidase 7 (matrilysin, uterine)
chr9_-_215892 3.946 NM_152569
C9orf66
chromosome 9 open reading frame 66
chr1_+_46972667 3.906 NM_147192
NM_172225
DMBX1

diencephalon/mesencephalon homeobox 1

chr19_-_18548788 3.895 NM_001170939
ISYNA1
inositol-3-phosphate synthase 1
chr5_-_24645084 3.882 NM_006727
CDH10
cadherin 10, type 2 (T2-cadherin)
chr5_+_147582338 3.806 NM_001195290
NM_205841
SPINK6

serine peptidase inhibitor, Kazal type 6

chr2_-_86564632 3.791 NM_001164731
NM_001164732
NM_022912
REEP1


receptor accessory protein 1


chr4_-_77819001 3.766 NM_001029870
ANKRD56
ankyrin repeat domain 56
chr19_-_37341168 3.637 NM_001242801
ZNF790
zinc finger protein 790
chr19_-_18548971 3.549 NM_001170938
NM_016368
ISYNA1

inositol-3-phosphate synthase 1

chr1_+_164528586 3.532 NM_001204961
NM_001204963
NM_002585
PBX1


pre-B-cell leukemia homeobox 1


chr20_+_44746948 3.435 CD40
CD40 molecule, TNF receptor superfamily member 5
chr11_+_66790815 3.429 NM_177963
SYT12
synaptotagmin XII
chr9_+_33795558 3.392 NM_002771
PRSS3
protease, serine, 3
chr12_-_42983412 3.362 NM_153026
PRICKLE1
prickle homolog 1 (Drosophila)
chr12_+_70759974 3.358 NM_014505
KCNMB4
potassium large conductance calcium-activated channel, subfamily M, beta member 4
chr7_-_142985270 3.357


chr1_-_146696896 3.356 FMO5
flavin containing monooxygenase 5
chr15_-_40600025 3.316 PLCB2
phospholipase C, beta 2
chr22_-_31688329 3.278 NM_001135911
NM_052880
PIK3IP1

phosphoinositide-3-kinase interacting protein 1

chr10_-_62703822 3.153 NM_001242359
NM_014836
RHOBTB1

Rho-related BTB domain containing 1

chr9_-_131872782 3.133 CRAT
carnitine O-acetyltransferase
chr2_-_238322770 3.131 COL6A3
collagen, type VI, alpha 3
chr1_-_110933635 3.053 SLC16A4
solute carrier family 16, member 4 (monocarboxylic acid transporter 5)
chr15_-_40600118 2.936 NM_004573
PLCB2
phospholipase C, beta 2
chr1_-_221915393 2.856 DUSP10
dual specificity phosphatase 10
chr3_-_190040192 2.826 NM_021101
CLDN1
claudin 1
chrX_-_153979161 2.804 NM_001081573
NM_080612
GAB3

GRB2-associated binding protein 3

chr19_-_10628111 2.777 NM_030760
S1PR5
sphingosine-1-phosphate receptor 5
chrX_+_105937067 2.756 NM_024539
RNF128
ring finger protein 128
chr1_-_221915458 2.750 NM_007207
NM_144729
DUSP10

dual specificity phosphatase 10

chr2_-_238322840 2.712 NM_004369
NM_057164
NM_057165
NM_057166
NM_057167
COL6A3




collagen, type VI, alpha 3




chr17_+_67410825 2.659 NM_002758
MAP2K6
mitogen-activated protein kinase kinase 6
chr1_-_110933683 2.658 NM_001201546
NM_001201547
NM_001201548
NM_001201549
NM_004696
SLC16A4




solute carrier family 16, member 4 (monocarboxylic acid transporter 5)




chrX_-_64139016 2.639 ZC4H2
zinc finger, C4H2 domain containing
chr9_+_17578952 2.592 NM_003026
SH3GL2
SH3-domain GRB2-like 2
chr10_-_98031154 2.579 NM_001114094
NM_013314
BLNK

B-cell linker

chr17_+_7452374 2.543 NM_172089
NM_003809
TNFSF12-TNFSF13
TNFSF12
TNFSF12-TNFSF13 readthrough
tumor necrosis factor (ligand) superfamily, member 12
chr17_-_80797889 2.537 NM_024702
ZNF750
zinc finger protein 750
chr20_+_58713521 2.517 LOC284757
uncharacterized LOC284757
chr5_-_168727715 2.513 NM_003062
SLIT3
slit homolog 3 (Drosophila)
chr9_-_99801924 2.511 NM_001201575
CTSL2
cathepsin L2
chr19_-_36019194 2.423 NM_001166034
NM_001166035
NM_198538
SBSN


suprabasin


chr20_+_45523247 2.403 NM_005244
NM_172110
EYA2

eyes absent homolog 2 (Drosophila)

chr9_+_90112419 2.377 DAPK1
death-associated protein kinase 1
chrX_-_119445306 2.358 NM_001104544
NM_001104545
NM_017938
FAM70A


family with sequence similarity 70, member A


chr17_+_38119225 2.335 NM_178171
GSDMA
gasdermin A
chrX_-_47931000 2.314 NM_001190255
ZNF630
zinc finger protein 630
chr19_+_15160194 2.311 NM_012114
CASP14
caspase 14, apoptosis-related cysteine peptidase
chrX_+_55478537 2.282 NM_014061
MAGEH1
melanoma antigen family H, 1
chr9_+_90112754 2.258 NM_004938
DAPK1
death-associated protein kinase 1
chr12_-_110271182 2.238 TRPV4
transient receptor potential cation channel, subfamily V, member 4
chr7_+_63774378 2.222 ZNF736
zinc finger protein 736
chr2_+_218990735 2.211 NM_001557
CXCR2
chemokine (C-X-C motif) receptor 2
chr15_+_68924326 2.209 NM_001190457
CORO2B
coronin, actin binding protein, 2B
chr16_-_19896105 2.208 NM_016235
GPRC5B
G protein-coupled receptor, family C, group 5, member B
chr12_-_8815266 2.206 MFAP5
microfibrillar associated protein 5
chr10_+_12391728 2.203 CAMK1D
calcium/calmodulin-dependent protein kinase ID
chr19_+_37407230 2.200 NM_001204835
NM_001204836
NM_001204837
NM_001204838
NM_001204839
NM_198539
ZNF568





zinc finger protein 568





chr10_-_95360959 2.177 NM_006744
RBP4
retinol binding protein 4, plasma
chr1_+_201252579 2.177 NM_000299
NM_001005337
PKP1

plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)

chr11_+_86511490 2.151 NM_007173
PRSS23
protease, serine, 23
chr19_-_375969 2.125 NM_016585
NM_199202
THEG

Theg homolog (mouse)

chr6_+_122931541 2.099 PKIB
protein kinase (cAMP-dependent, catalytic) inhibitor beta
chrX_+_84498993 2.082 NM_021998
ZNF711
zinc finger protein 711
chr8_+_32785485 2.082


chr17_-_19770988 2.072 NM_001142610
NM_014683
ULK2

unc-51-like kinase 2 (C. elegans)

chr20_+_51589752 2.067 TSHZ2
teashirt zinc finger homeobox 2
chr3_-_119963141 2.066 NM_001168271
NM_153002
GPR156

G protein-coupled receptor 156

chr15_+_74218794 2.059 LOXL1
lysyl oxidase-like 1
chr15_-_40599872 2.056 PLCB2
phospholipase C, beta 2
chr5_-_39424930 2.043 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr1_+_209878135 2.042 NM_005525
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr12_+_41086189 2.031 NM_001843
NM_175038
CNTN1

contactin 1

chr20_+_45523523 2.030 EYA2
eyes absent homolog 2 (Drosophila)
chr1_-_85741992 2.029 BCL10
B-cell CLL/lymphoma 10
chr10_+_12391471 2.003 NM_020397
NM_153498
CAMK1D

calcium/calmodulin-dependent protein kinase ID

chr6_+_26045611 1.996 NM_003531
HIST1H3C
histone cluster 1, H3c
chr10_-_72142344 1.996 NM_018205
NM_018239
LRRC20

leucine rich repeat containing 20

chr15_+_74218811 1.983 LOXL1
lysyl oxidase-like 1
chr11_+_111808017 1.973 DIXDC1
DIX domain containing 1
chr6_+_101846860 1.958 NM_001166247
NM_021956
NM_175768
GRIK2


glutamate receptor, ionotropic, kainate 2


chr16_-_14788429 1.952 NM_003561
PLA2G10
phospholipase A2, group X
chr17_+_3379295 1.932 NM_000049
ASPA
aspartoacylase
chr3_-_108672547 1.905 NM_005459
GUCA1C
guanylate cyclase activator 1C
chr3_+_121796695 1.904 NM_006889
NM_176892
CD86

CD86 molecule

chr5_-_39425297 1.897 NM_001244871
NM_001343
DAB2

disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)

chr3_+_100211554 1.881 TMEM45A
transmembrane protein 45A
chr2_-_70781146 1.881 NM_001099691
NM_003236
TGFA

transforming growth factor, alpha

chr5_-_157002739 1.868 NM_033274
ADAM19
ADAM metallopeptidase domain 19
chr1_-_183387404 1.864


chr12_-_71031174 1.861 NM_001109754
PTPRB
protein tyrosine phosphatase, receptor type, B
chr19_-_4517715 1.860 NM_001080400
PLIN4
perilipin 4
chr20_-_17539480 1.850 NM_001161705
BFSP1
beaded filament structural protein 1, filensin
chr16_-_82045045 1.835 NM_145168
SDR42E1
short chain dehydrogenase/reductase family 42E, member 1
chr2_+_187454724 1.815 NM_001145000
NM_002210
ITGAV

integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)

chr1_-_150738255 1.813 CTSS
cathepsin S
chrX_+_84499037 1.812 ZNF711
zinc finger protein 711
chr19_+_37959981 1.811 NM_144694
ZNF570
zinc finger protein 570
chr1_-_111743080 1.799


chrX_+_22050920 1.796 NM_000444
PHEX
phosphate regulating endopeptidase homolog, X-linked
chr10_-_126138549 1.782 NM_001146340
NKX1-2
NK1 homeobox 2
chr1_+_154301219 1.781 ATP8B2
ATPase, class I, type 8B, member 2
chr15_+_57668702 1.775 NM_001252335
NM_032866
CGNL1

cingulin-like 1

chr2_+_48757063 1.774 NM_001198593
STON1-GTF2A1L
STON1-GTF2A1L readthrough
chr5_-_121412805 1.766 NM_001178102
LOX
lysyl oxidase
chrX_-_15288172 1.759 NM_001031739
NM_001168530
NM_024087
ASB9


ankyrin repeat and SOCS box containing 9


chr7_+_29234325 1.758 CHN2
chimerin (chimaerin) 2
chr1_-_183387501 1.749 NM_015039
NMNAT2
nicotinamide nucleotide adenylyltransferase 2
chrX_-_153095332 1.749 PDZD4
PDZ domain containing 4
chr19_-_12251092 1.745 NM_001203250
NM_021143
ZNF20

zinc finger protein 20

chr4_-_74853819 1.739 NM_002704
PPBP
pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
chr1_+_149871154 1.737 NM_016074
BOLA1
bolA homolog 1 (E. coli)
chr7_+_2557496 1.723 NM_002304
LFNG
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr18_+_28898051 1.718 NM_001942
DSG1
desmoglein 1
chr21_-_46340776 1.717 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr15_+_74218962 1.711 LOXL1
lysyl oxidase-like 1
chr2_-_127977653 1.704 CYP27C1
cytochrome P450, family 27, subfamily C, polypeptide 1
chr11_-_125366048 1.699 NM_005103
NM_022549
FEZ1

fasciculation and elongation protein zeta 1 (zygin I)

chr3_+_16216155 1.693 NM_054110
GALNTL2
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 2
chr12_+_21679190 1.693 NM_030572
C12orf39
chromosome 12 open reading frame 39
chr4_-_25032306 1.691 NM_018176
LGI2
leucine-rich repeat LGI family, member 2
chr21_+_30671736 1.689 NM_206866
BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr2_-_19558371 1.684 NM_145260
OSR1
odd-skipped related 1 (Drosophila)
chrX_-_153979796 1.680 GAB3
GRB2-associated binding protein 3
chr22_+_24115035 1.676 NM_005940
MMP11
matrix metallopeptidase 11 (stromelysin 3)
chr2_-_161056573 1.673 NM_000888
ITGB6
integrin, beta 6
chr2_+_150187028 1.660 NM_194317
LYPD6
LY6/PLAUR domain containing 6
chr12_+_56732658 1.658 NM_016584
IL23A
interleukin 23, alpha subunit p19
chr5_-_111093030 1.654 NM_001142482
NM_001142481
C5orf13

chromosome 5 open reading frame 13

chr3_+_132036210 1.649 NM_001099
NM_001134194
ACPP

acid phosphatase, prostate

chr1_+_28199053 1.648 NM_001039477
NM_001105556
NM_004848
C1orf38


chromosome 1 open reading frame 38


chr19_-_14169970 1.636 NM_001145028
PALM3
paralemmin 3
chr5_-_39425030 1.636 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr3_-_197282805 1.633 NM_004051
NM_203314
BDH1

3-hydroxybutyrate dehydrogenase, type 1

chr8_-_79717540 1.632 NM_000880
NM_001199886
NM_001199887
NM_001199888
IL7



interleukin 7



chr3_+_186648273 1.628 NM_173216
NM_173217
ST6GAL1

ST6 beta-galactosamide alpha-2,6-sialyltranferase 1

chr12_+_4382882 1.618 NM_001759
CCND2
cyclin D2
chr12_+_569542 1.613 NM_173593
B4GALNT3
beta-1,4-N-acetyl-galactosaminyl transferase 3
chr12_-_8815479 1.612 MFAP5
microfibrillar associated protein 5
chr1_-_111743261 1.610 NM_024901
DENND2D
DENN/MADD domain containing 2D
chrX_+_37430821 1.585 NM_001170331
NM_198511
LANCL3

LanC lantibiotic synthetase component C-like 3 (bacterial)

chr20_-_1165116 1.576 NM_018354
TMEM74B
transmembrane protein 74B
chr16_+_80574853 1.564 NM_130897
DYNLRB2
dynein, light chain, roadblock-type 2
chr15_+_74218786 1.558 NM_005576
LOXL1
lysyl oxidase-like 1
chr9_-_36276930 1.558 NM_001128227
NM_001190388
GNE

glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase

chr6_+_122931376 1.554 NM_032471
NM_181795
PKIB

protein kinase (cAMP-dependent, catalytic) inhibitor beta

chr3_+_173116243 1.550 NM_014932
NLGN1
neuroligin 1
chr11_-_22851266 1.539 NM_148893
SVIP
small VCP/p97-interacting protein
chr5_-_111093251 1.536 NM_001142479
NM_001142480
NM_001142478
C5orf13


chromosome 5 open reading frame 13


chr3_-_108248168 1.529 NM_014981
MYH15
myosin, heavy chain 15
chr21_-_46340821 1.508 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.64 7.65e-03 GO:0007275 multicellular organismal development
1.56 2.97e-02 GO:0032502 developmental process

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
2.29 5.42e-08 GO:0005576 extracellular region
2.96 9.80e-08 GO:0044421 extracellular region part
3.97 2.93e-05 GO:0031012 extracellular matrix
4.21 5.11e-05 GO:0005578 proteinaceous extracellular matrix
2.79 9.94e-05 GO:0005615 extracellular space
6.34 6.57e-04 GO:0044420 extracellular matrix part
2.04 1.19e-02 GO:0005887 integral to plasma membrane
2.01 1.70e-02 GO:0031226 intrinsic to plasma membrane
21.47 4.70e-02 GO:0030934 anchoring collagen

Nothing significant found in function category.