Motif ID: NKX3-1.p2

Z-value: 0.844


Transcription factors associated with NKX3-1.p2:

Gene SymbolEntrez IDGene Name
NKX3-1 4824 NK3 homeobox 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NKX3-1hg19_v1_chr8_-_23540401_235404620.209.2e-02Click!


Activity profile for motif NKX3-1.p2.

activity profile for motif NKX3-1.p2


Sorted Z-values histogram for motif NKX3-1.p2

Sorted Z-values for motif NKX3-1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX3-1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_102953716 5.025 NM_003856
IL1RL1
interleukin 1 receptor-like 1
chr18_+_61554938 5.002 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr3_-_119963141 3.926 NM_001168271
NM_153002
GPR156

G protein-coupled receptor 156

chr20_+_58713521 3.418 LOC284757
uncharacterized LOC284757
chr17_-_29641094 2.901 NM_006495
EVI2B
ecotropic viral integration site 2B
chr12_+_50869531 2.795 LARP4
La ribonucleoprotein domain family, member 4
chr14_-_101036130 2.753 NM_020836
BEGAIN
brain-enriched guanylate kinase-associated homolog (rat)
chr14_+_67831484 2.517 EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr1_+_192127591 2.511 NM_130782
RGS18
regulator of G-protein signaling 18
chr3_-_194188967 2.499 NM_024524
ATP13A3
ATPase type 13A3
chr14_-_106610338 2.440 IGHV4-31
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant gamma 1 (G1m marker)
chr5_-_137475076 2.400 NM_003551
NME5
non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase)
chr19_+_49078992 2.356 NM_004605
SULT2B1
sulfotransferase family, cytosolic, 2B, member 1
chrX_+_107288199 2.306 NM_001170553
NM_182607
VSIG1

V-set and immunoglobulin domain containing 1

chr3_-_149086884 2.277 TM4SF1
transmembrane 4 L six family member 1
chr6_+_30130982 2.272 NM_033229
TRIM15
tripartite motif containing 15
chr7_-_93519990 2.252 NM_006528
TFPI2
tissue factor pathway inhibitor 2
chr5_+_92918924 2.241 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr7_+_28475233 2.219 NM_004904
CREB5
cAMP responsive element binding protein 5
chr7_-_41742666 2.192 NM_002192
INHBA
inhibin, beta A
chr11_-_57158103 2.160 NM_001243245
NM_002728
PRG2

proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)

chr13_+_42712177 2.103 NM_001204505
NM_001204506
DGKH

diacylglycerol kinase, eta

chr2_+_228356287 2.088 AGFG1
ArfGAP with FG repeats 1
chr7_-_107880492 2.041 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr9_+_21440452 1.988 NM_024013
IFNA1
interferon, alpha 1
chr5_+_126859157 1.967 PRRC1
proline-rich coiled-coil 1
chr2_+_103378489 1.921 NM_144632
TMEM182
transmembrane protein 182
chr6_-_138820580 1.905


chr10_-_14816895 1.892 NM_031453
FAM107B
family with sequence similarity 107, member B
chr17_+_74463629 1.852 NM_001088
AANAT
aralkylamine N-acetyltransferase
chr4_+_47708350 1.735


chr5_-_98262217 1.650 NM_001270
CHD1
chromodomain helicase DNA binding protein 1
chr3_-_197300193 1.646 NM_203315
BDH1
3-hydroxybutyrate dehydrogenase, type 1
chr1_-_244006885 1.638 NM_001206729
AKT3
v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
chr16_+_82068958 1.638 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr16_+_82068830 1.604 NM_002153
HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr18_-_52625278 1.595 NM_001143829
CCDC68
coiled-coil domain containing 68
chr2_+_102927961 1.573 NM_016232
IL18R1
IL1RL1
interleukin 18 receptor 1
interleukin 1 receptor-like 1
chr2_+_114674505 1.561 ACTR3
ARP3 actin-related protein 3 homolog (yeast)
chr1_-_68915631 1.552 NM_000329
RPE65
retinal pigment epithelium-specific protein 65kDa
chr6_+_12514300 1.530


chr3_+_119013216 1.506 NM_020754
ARHGAP31
Rho GTPase activating protein 31
chr1_+_199996729 1.456 NM_003822
NM_205860
NR5A2

nuclear receptor subfamily 5, group A, member 2

chrX_-_13835012 1.454 GPM6B
glycoprotein M6B
chr14_-_75600111 1.430 TMED10
transmembrane emp24-like trafficking protein 10 (yeast)
chr16_+_82068910 1.323 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr10_+_5488521 1.314 NM_005863
NET1
neuroepithelial cell transforming 1
chr12_-_50595303 1.295 NM_001243775
LIMA1
LIM domain and actin binding 1
chr6_-_76782204 1.257 NM_001563
IMPG1
interphotoreceptor matrix proteoglycan 1
chr8_+_26150731 1.236 NM_001177591
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr12_+_65224214 1.234


chr17_-_7493389 1.227 NM_006942
SOX15
SRY (sex determining region Y)-box 15
chrX_+_49687212 1.207 NM_001127898
NM_001127899
CLCN5

chloride channel 5

chr11_-_78052925 1.124 NM_012296
GAB2
GRB2-associated binding protein 2
chr10_+_97759847 1.113 NM_001001732
NM_001159747
CC2D2B

coiled-coil and C2 domain containing 2B

chr7_+_48075107 1.102 NM_001100159
C7orf57
chromosome 7 open reading frame 57
chr5_+_147691988 1.100 NM_032566
SPINK7
serine peptidase inhibitor, Kazal type 7 (putative)
chr15_+_25068793 1.064 NM_022806
NM_022807
NM_022808
SNRPN


small nuclear ribonucleoprotein polypeptide N


chr3_-_44489718 1.058


chrX_+_71364033 1.035 NM_207422
FLJ44635
TPT1-like protein
chr7_-_123673486 1.029 NM_001136002
TMEM229A
transmembrane protein 229A
chr15_-_80263460 1.022 NM_001114735
NM_004049
BCL2A1

BCL2-related protein A1

chr18_+_72167021 0.980 CNDP2
CNDP dipeptidase 2 (metallopeptidase M20 family)
chr2_-_224866616 0.977 SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr4_-_289943 0.976 NM_001137608
ZNF732
zinc finger protein 732
chr14_+_94492747 0.928 OTUB2
OTU domain, ubiquitin aldehyde binding 2
chr5_-_94224601 0.918 MCTP1
multiple C2 domains, transmembrane 1
chr12_-_80084742 0.906 NM_002583
PAWR
PRKC, apoptosis, WT1, regulator
chr11_+_128564130 0.906 FLI1
Friend leukemia virus integration 1
chr15_+_66694216 0.898 MAP2K1
mitogen-activated protein kinase kinase 1
chr1_-_51887740 0.894 NM_001159969
EPS15
epidermal growth factor receptor pathway substrate 15
chr2_-_10942642 0.883 PDIA6
protein disulfide isomerase family A, member 6
chr7_-_66460403 0.868 NM_016038
SBDS
Shwachman-Bodian-Diamond syndrome
chr18_+_33234532 0.866 NM_020474
GALNT1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)
chr18_-_64271215 0.864 NM_021153
CDH19
cadherin 19, type 2
chr4_+_74301932 0.853 NM_001134
AFP
alpha-fetoprotein
chr7_+_72300044 0.851 SBDSP1
Shwachman-Bodian-Diamond syndrome pseudogene 1
chr13_-_41706587 0.847 NM_152903
KBTBD6
kelch repeat and BTB (POZ) domain containing 6
chr11_+_33363104 0.829 HIPK3
homeodomain interacting protein kinase 3
chr6_-_32160637 0.828 GPSM3
G-protein signaling modulator 3
chr9_+_21409132 0.825 NM_002170
IFNA8
interferon, alpha 8
chr3_-_74570262 0.824 NM_020872
CNTN3
contactin 3 (plasmacytoma associated)
chr6_-_138820578 0.823 NM_001144060
NHSL1
NHS-like 1
chr11_-_105010460 0.823 NM_021571
CARD18
caspase recruitment domain family, member 18
chrX_+_115301957 0.820 NM_000686
AGTR2
angiotensin II receptor, type 2
chr1_-_33841142 0.818 NM_198040
PHC2
polyhomeotic homolog 2 (Drosophila)
chr14_+_94492683 0.816 NM_023112
OTUB2
OTU domain, ubiquitin aldehyde binding 2
chr11_+_12308446 0.814 NM_032867
MICALCL
MICAL C-terminal like
chrX_+_114827818 0.809 NM_001136025
NM_001172335
PLS3

plastin 3

chr12_+_121132677 0.801


chr3_+_44692500 0.799 ZNF35
zinc finger protein 35
chr11_+_71589498 0.797 NM_001242853
LOC100129216
beta-defensin 131-like
chr17_-_42144986 0.796 NM_152344
LSM12
LSM12 homolog (S. cerevisiae)
chr17_+_61086897 0.794 NM_025185
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr6_-_136847078 0.784 NM_001198608
NM_001198609
NM_001198611
MAP7


microtubule-associated protein 7


chrX_-_100548044 0.783 NM_024885
TAF7L
TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa
chrY_-_1281526 0.782 NM_001012288
NM_022148
CRLF2

cytokine receptor-like factor 2

chr6_+_131958441 0.778 NM_005021
ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr2_-_27718098 0.769 NM_022823
FNDC4
fibronectin type III domain containing 4
chr2_-_27718059 0.765 FNDC4
fibronectin type III domain containing 4
chr19_-_42947050 0.760 NM_198477
CXCL17
chemokine (C-X-C motif) ligand 17
chr2_+_135596185 0.747 NM_138326
ACMSD
aminocarboxymuconate semialdehyde decarboxylase
chr14_+_62164339 0.746 NM_001243084
HIF1A
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
chr1_-_86043932 0.742 NM_001134445
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr9_-_25678855 0.727 NM_001004125
TUSC1
tumor suppressor candidate 1
chr19_-_55580896 0.722 NM_138412
RDH13
retinol dehydrogenase 13 (all-trans/9-cis)
chr3_+_132318980 0.716 NM_178445
CCRL1
chemokine (C-C motif) receptor-like 1
chr8_+_23101149 0.690 NM_152272
CHMP7
charged multivesicular body protein 7
chr11_+_6942204 0.678 NM_001004684
OR2D3
olfactory receptor, family 2, subfamily D, member 3
chr16_+_4845265 0.673 NM_001253793
NM_001253794
LOC440335

uncharacterized LOC440335

chr11_-_104827421 0.668 NM_033306
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr10_+_102121371 0.654 SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr9_-_139334274 0.653 INPP5E
inositol polyphosphate-5-phosphatase, 72 kDa
chr1_+_145883867 0.647 NM_001097616
GPR89C
G protein-coupled receptor 89C
chr12_-_81763127 0.639 NM_001220479
NM_001220480
PPFIA2

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2

chr3_-_183273407 0.636 NM_130446
KLHL6
kelch-like 6 (Drosophila)
chr6_-_111888520 0.634 NM_001164283
TRAF3IP2
TRAF3 interacting protein 2
chr4_+_146031528 0.631 ABCE1
ATP-binding cassette, sub-family E (OABP), member 1
chr11_-_102651321 0.629 NM_002425
MMP10
matrix metallopeptidase 10 (stromelysin 2)
chr8_-_17743062 0.626 FGL1
fibrinogen-like 1
chr17_-_29641087 0.626 EVI2B
ecotropic viral integration site 2B
chr3_-_27498244 0.622 NM_003615
SLC4A7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
chr2_-_40657419 0.616 NM_001112800
NM_001112801
NM_001252624
NM_021097
SLC8A1



solute carrier family 8 (sodium/calcium exchanger), member 1



chrX_-_114252132 0.614 NM_000640
IL13RA2
interleukin 13 receptor, alpha 2
chr8_-_86253863 0.612 NM_001164830
CA1
carbonic anhydrase I
chr7_+_112092112 0.612 NM_001197079
IFRD1
interferon-related developmental regulator 1
chr14_+_24774429 0.611


chr7_+_44240606 0.606 YKT6
YKT6 v-SNARE homolog (S. cerevisiae)
chr21_-_31538970 0.598 NM_012131
CLDN17
claudin 17
chr4_-_71532206 0.597 IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr3_-_71353910 0.596 NM_001244812
FOXP1
forkhead box P1
chr12_+_93963597 0.595 NM_003877
SOCS2
suppressor of cytokine signaling 2
chr2_-_88285308 0.592 NM_001024457
RGPD1
RANBP2-like and GRIP domain containing 1
chr10_-_69752385 0.589 HERC4
hect domain and RLD 4
chr13_-_99910548 0.589 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chr14_-_107013122 0.589 IGHV4-31
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant gamma 1 (G1m marker)
chr2_+_70121074 0.585 NM_006857
SNRNP27
small nuclear ribonucleoprotein 27kDa (U4/U6.U5)
chr4_-_6422844 0.583 NM_001206996
PPP2R2C
protein phosphatase 2, regulatory subunit B, gamma
chr2_+_120770606 0.583 NM_001184938
EPB41L5
erythrocyte membrane protein band 4.1 like 5
chr13_-_75901897 0.582 TBC1D4
TBC1 domain family, member 4
chr7_-_115608366 0.580 NM_001244583
TFEC
transcription factor EC
chr4_-_177190258 0.577 NM_080874
ASB5
ankyrin repeat and SOCS box containing 5
chr2_+_169757749 0.576 NM_001081686
NM_021176
G6PC2

glucose-6-phosphatase, catalytic, 2

chr6_+_7402879 0.574 NM_153005
RIOK1
RIO kinase 1 (yeast)
chr2_-_47143250 0.573 NM_001171507
NM_001171510
MCFD2

multiple coagulation factor deficiency 2

chr2_+_183582667 0.573 DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr8_+_25042066 0.572 DOCK5
dedicator of cytokinesis 5
chr4_-_76957139 0.572 NM_005409
CXCL11
chemokine (C-X-C motif) ligand 11
chr14_-_35344852 0.570 NM_013448
NM_182648
BAZ1A

bromodomain adjacent to zinc finger domain, 1A

chr20_-_52199635 0.568 NM_006526
ZNF217
zinc finger protein 217
chr5_+_147582338 0.565 NM_001195290
NM_205841
SPINK6

serine peptidase inhibitor, Kazal type 6

chr10_+_5772610 0.562 FAM208B
family with sequence similarity 208, member B
chr16_+_21695749 0.561 NM_001161683
OTOA
otoancorin
chr1_+_84874033 0.561 NM_058248
DNASE2B
deoxyribonuclease II beta
chr1_+_120049825 0.557 NM_000862
HSD3B1
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
chr1_+_15990300 0.553


chr7_+_44240638 0.551 YKT6
YKT6 v-SNARE homolog (S. cerevisiae)
chr21_-_43346780 0.550 NM_199050
C2CD2
C2 calcium-dependent domain containing 2
chr10_+_94594469 0.548 NM_001013848
EXOC6
exocyst complex component 6
chr2_-_216245573 0.547 FN1
fibronectin 1
chr12_+_47610244 0.547 FAM113B
family with sequence similarity 113, member B
chr7_-_137620651 0.542 CREB3L2
cAMP responsive element binding protein 3-like 2
chr9_-_104198045 0.538 NM_000035
ALDOB
aldolase B, fructose-bisphosphate
chr9_-_95166827 0.536 NM_014057
NM_033014
OGN

osteoglycin

chr2_-_100046262 0.533 REV1
REV1 homolog (S. cerevisiae)
chr12_+_21679190 0.532 NM_030572
C12orf39
chromosome 12 open reading frame 39
chr2_+_219125737 0.532 NM_001077191
NM_001077194
NM_170699
GPBAR1


G protein-coupled bile acid receptor 1


chr12_+_93096618 0.531 NM_001037671
NM_001178097
C12orf74

chromosome 12 open reading frame 74

chr9_+_130026755 0.528 NM_032293
GARNL3
GTPase activating Rap/RanGAP domain-like 3
chr19_-_20748540 0.527 NM_001159293
ZNF737
zinc finger protein 737
chr8_+_104426941 0.525 NM_015420
DCAF13
DDB1 and CUL4 associated factor 13
chr5_+_140261792 0.522 NM_018904
NM_031865
PCDHA13

protocadherin alpha 13

chr1_+_84630575 0.520 NM_001242860
NM_001242861
PRKACB

protein kinase, cAMP-dependent, catalytic, beta

chr10_+_54074037 0.516 NM_012242
DKK1
dickkopf 1 homolog (Xenopus laevis)
chr12_+_2921786 0.514 NM_018463
ITFG2
integrin alpha FG-GAP repeat containing 2
chr6_-_51952368 0.514 NM_138694
NM_170724
PKHD1

polycystic kidney and hepatic disease 1 (autosomal recessive)

chr4_-_187527219 0.514


chr3_-_71180061 0.513 NM_001244815
FOXP1
forkhead box P1
chr15_+_80733579 0.513 ARNT2
aryl-hydrocarbon receptor nuclear translocator 2
chr11_+_118257222 0.512 UBE4A
ubiquitination factor E4A
chr19_+_36239261 0.511 NM_019104
LIN37
lin-37 homolog (C. elegans)
chr17_-_29641068 0.511 EVI2B
ecotropic viral integration site 2B
chrX_-_138286434 0.509 FGF13
fibroblast growth factor 13
chr17_-_38859976 0.508 NM_019016
KRT24
keratin 24
chr1_+_171481164 0.506 PRRC2C
proline-rich coiled-coil 2C
chr1_+_146649544 0.505


chr5_+_179132676 0.505 CANX
calnexin
chr20_+_62795826 0.504 NM_004535
MYT1
myelin transcription factor 1
chr7_+_128349111 0.504 FAM71F1
family with sequence similarity 71, member F1
chr21_+_30400229 0.503 USP16
ubiquitin specific peptidase 16
chr10_-_65028825 0.503 NM_004241
JMJD1C
jumonji domain containing 1C
chr2_+_170662044 0.503 SSB
Sjogren syndrome antigen B (autoantigen La)
chr12_-_14996381 0.502 NM_021071
ART4
ADP-ribosyltransferase 4 (Dombrock blood group)
chr11_-_3803310 0.502 NUP98
nucleoporin 98kDa
chr15_+_94899163 0.500 NM_001159644
MCTP2
multiple C2 domains, transmembrane 2
chr17_-_16875388 0.499 NM_012452
TNFRSF13B
tumor necrosis factor receptor superfamily, member 13B
chr1_+_24840800 0.499 NM_001251980
NM_001251982
NM_001251985
RCAN3


RCAN family member 3


chr4_+_147096834 0.498 NM_007080
LSM6
LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr18_+_61582744 0.497 NM_005024
SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr9_-_125941304 0.495 STRBP
spermatid perinuclear RNA binding protein

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.