Motif ID: NKX2-3_NKX2-5.p2

Z-value: 1.096


Transcription factors associated with NKX2-3_NKX2-5.p2:

Gene SymbolEntrez IDGene Name
NKX2-3 159296 NK2 transcription factor related, locus 3 (Drosophila)
NKX2-5 1482 NK2 transcription factor related, locus 5 (Drosophila)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NKX2-5hg19_v1_chr5_-_172662085_172662314-0.352.2e-03Click!
NKX2-3hg19_v1_chr10_+_101292689_101292737-0.066.1e-01Click!


Activity profile for motif NKX2-3_NKX2-5.p2.

activity profile for motif NKX2-3_NKX2-5.p2


Sorted Z-values histogram for motif NKX2-3_NKX2-5.p2

Sorted Z-values for motif NKX2-3_NKX2-5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-3_NKX2-5.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_-_64196268 16.673 NM_001178033
NM_018684
ZC4H2

zinc finger, C4H2 domain containing

chr3_-_74570262 13.537 NM_020872
CNTN3
contactin 3 (plasmacytoma associated)
chr7_-_14025826 13.528 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr12_-_28124915 13.295 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr19_+_45409003 12.336 NM_000041
APOE
apolipoprotein E
chr5_+_59784004 9.794 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr18_+_28898051 9.788 NM_001942
DSG1
desmoglein 1
chr17_-_78450247 9.722 NM_002522
NPTX1
neuronal pentraxin I
chr5_+_147582338 9.294 NM_001195290
NM_205841
SPINK6

serine peptidase inhibitor, Kazal type 6

chr5_+_52776479 9.258 FST
follistatin
chr12_+_9980076 8.738 NM_016523
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chr2_-_216245573 8.546 FN1
fibronectin 1
chr6_+_136172802 8.478 NM_018945
PDE7B
phosphodiesterase 7B
chr4_+_69313166 8.447 NM_014058
TMPRSS11E
transmembrane protease, serine 11E
chr1_-_110933635 8.373 SLC16A4
solute carrier family 16, member 4 (monocarboxylic acid transporter 5)
chr9_+_131870105 7.330


chr1_-_150738232 7.084 CTSS
cathepsin S
chr4_-_110723127 6.958 CFI
complement factor I
chr3_-_119963141 6.604 NM_001168271
NM_153002
GPR156

G protein-coupled receptor 156

chrX_+_115567746 6.502 NM_007231
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr7_-_83270746 6.439 NM_001178129
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr1_-_110933683 6.244 NM_001201546
NM_001201547
NM_001201548
NM_001201549
NM_004696
SLC16A4




solute carrier family 16, member 4 (monocarboxylic acid transporter 5)




chr12_+_41086189 6.144 NM_001843
NM_175038
CNTN1

contactin 1

chr1_+_152974222 5.999 NM_001097589
NM_005416
SPRR3

small proline-rich protein 3

chr19_+_48828820 5.885 EMP3
epithelial membrane protein 3
chr3_+_173116243 5.596 NM_014932
NLGN1
neuroligin 1
chr15_+_25281105 5.537 SNRPN
small nuclear ribonucleoprotein polypeptide N
chr2_+_102953716 5.362 NM_003856
IL1RL1
interleukin 1 receptor-like 1
chr5_+_140602914 5.340 NM_018934
PCDHB14
protocadherin beta 14
chr1_+_209878135 5.312 NM_005525
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr3_-_99833348 5.172 NM_001042459
NM_182909
FILIP1L

filamin A interacting protein 1-like

chr12_-_89745753 5.150 DUSP6
dual specificity phosphatase 6
chr19_+_48828627 5.050 NM_001425
EMP3
epithelial membrane protein 3
chr5_+_71502700 4.976 MAP1B
microtubule-associated protein 1B
chr7_+_28452143 4.735 NM_182898
CREB5
cAMP responsive element binding protein 5
chr5_+_53751430 4.551 NM_006308
HSPB3
heat shock 27kDa protein 3
chr5_-_137475076 4.497 NM_003551
NME5
non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase)
chr7_+_28475233 4.467 NM_004904
CREB5
cAMP responsive element binding protein 5
chr3_-_52090090 4.455 NM_001947
DUSP7
dual specificity phosphatase 7
chr14_-_101036130 4.047 NM_020836
BEGAIN
brain-enriched guanylate kinase-associated homolog (rat)
chr1_-_153044083 3.994 NM_001017418
SPRR2B
small proline-rich protein 2B
chr9_-_85882093 3.978 NM_001244962
FRMD3
FERM domain containing 3
chr9_+_118916069 3.974 NM_002581
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr9_-_215892 3.964 NM_152569
C9orf66
chromosome 9 open reading frame 66
chrX_+_107288199 3.941 NM_001170553
NM_182607
VSIG1

V-set and immunoglobulin domain containing 1

chr5_+_140247767 3.859 NM_018902
NM_031861
PCDHA11

protocadherin alpha 11

chr3_+_8543508 3.759 NM_014583
LMCD1
LIM and cysteine-rich domains 1
chr2_-_161056573 3.707 NM_000888
ITGB6
integrin, beta 6
chr5_-_24645084 3.600 NM_006727
CDH10
cadherin 10, type 2 (T2-cadherin)
chr12_+_29376596 3.584 NM_018099
FAR2
fatty acyl CoA reductase 2
chr4_-_110723334 3.519 NM_000204
CFI
complement factor I
chr13_-_86373328 3.445 NM_032229
SLITRK6
SLIT and NTRK-like family, member 6
chrX_-_64139016 3.374 ZC4H2
zinc finger, C4H2 domain containing
chr10_+_102732285 3.369 NM_001203244
NM_017893
SEMA4G

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G

chr3_+_186739643 3.344 NM_003032
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr12_+_58005217 3.320 NM_182947
ARHGEF25
Rho guanine nucleotide exchange factor (GEF) 25
chr6_+_121756744 3.299 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr1_-_42384370 3.231 NM_001127714
NM_024503
HIVEP3

human immunodeficiency virus type I enhancer binding protein 3

chr10_-_105845556 3.190 COL17A1
collagen, type XVII, alpha 1
chr8_-_82395401 3.153 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr1_-_150738255 3.141 CTSS
cathepsin S
chr1_-_116383692 3.108 NM_005599
NHLH2
nescient helix loop helix 2
chr5_+_140235594 3.070 NM_018901
NM_031859
NM_031860
PCDHA10


protocadherin alpha 10


chr10_-_105845619 3.040 NM_000494
COL17A1
collagen, type XVII, alpha 1
chr7_-_92777657 3.036 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr2_-_216249682 3.009 FN1
fibronectin 1
chr13_-_36429798 2.985 NM_001195415
NM_001195416
NM_001195430
DCLK1


doublecortin-like kinase 1


chr5_-_141993691 2.954 NM_033137
FGF1
fibroblast growth factor 1 (acidic)
chr19_+_37342552 2.837 NM_001242475
NM_001242476
ZNF345

zinc finger protein 345

chr8_-_23712297 2.820 NM_003155
STC1
stanniocalcin 1
chr3_+_16216155 2.807 NM_054110
GALNTL2
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 2
chr8_+_7738908 2.786 NM_018661
DEFB103B
defensin, beta 103B
chr3_+_8543539 2.747 LMCD1
LIM and cysteine-rich domains 1
chr4_+_156587861 2.736 NM_000856
NM_001130682
NM_001130686
NM_001130687
NM_001130683
NM_001130685
GUCY1A3





guanylate cyclase 1, soluble, alpha 3





chrX_+_102631267 2.715 NM_206915
NM_206917
NGFRAP1

nerve growth factor receptor (TNFRSF16) associated protein 1

chr13_+_78109808 2.682 NM_001160706
NM_003843
NM_144777
SCEL


sciellin


chr9_+_125132823 2.663 PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr8_-_7287651 2.658 NM_018661
DEFB103B
defensin, beta 103B
chrX_+_105937067 2.651 NM_024539
RNF128
ring finger protein 128
chr2_+_179184970 2.625 NM_145739
OSBPL6
oxysterol binding protein-like 6
chr10_-_5446781 2.605 NM_001171864
NM_024803
TUBAL3

tubulin, alpha-like 3

chr6_-_47253962 2.566 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr13_+_99058147 2.544


chr1_-_153085963 2.529 NM_001014450
SPRR2A
SPRR2F
small proline-rich protein 2A
small proline-rich protein 2F
chr8_-_110655418 2.487 NM_001099756
SYBU
syntabulin (syntaxin-interacting)
chr1_+_215178884 2.452 NM_001017424
KCNK2
potassium channel, subfamily K, member 2
chr5_+_140186658 2.425 NM_018907
NM_031500
PCDHA4

protocadherin alpha 4

chr13_+_53602829 2.419 NM_006418
OLFM4
olfactomedin 4
chr12_+_105153258 2.413 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr3_+_121796695 2.375 NM_006889
NM_176892
CD86

CD86 molecule

chr6_-_11779279 2.370 NM_001143948
NM_032744
C6orf105

chromosome 6 open reading frame 105

chr9_+_125132785 2.366 PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chrX_+_115567820 2.352 SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr3_+_159943252 2.333 NM_001168214
C3orf80
chromosome 3 open reading frame 80
chr7_+_100770378 2.309 NM_000602
NM_001165413
SERPINE1

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

chrX_-_114252132 2.265 NM_000640
IL13RA2
interleukin 13 receptor, alpha 2
chr5_-_168271852 2.251


chrX_+_22050920 2.232 NM_000444
PHEX
phosphate regulating endopeptidase homolog, X-linked
chr12_+_75874512 2.231 NM_006851
GLIPR1
GLI pathogenesis-related 1
chr17_+_39555993 2.206 GAST
gastrin
chr12_-_89746238 2.204 DUSP6
dual specificity phosphatase 6
chr4_-_186733372 2.185 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr10_+_69869249 2.176 NM_032578
MYPN
myopalladin
chr4_-_74853819 2.171 NM_002704
PPBP
pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
chr12_+_8975149 2.148 NM_144670
A2ML1
alpha-2-macroglobulin-like 1
chr2_+_48796158 2.135 NM_172311
STON1-GTF2A1L
STON1-GTF2A1L readthrough
chr5_+_140810126 2.128 NM_003735
NM_032094
PCDHGA12

protocadherin gamma subfamily A, 12

chr10_-_98031154 2.126 NM_001114094
NM_013314
BLNK

B-cell linker

chr7_-_14029641 2.123 NM_001163147
NM_004956
ETV1

ets variant 1

chr8_-_110620220 2.075 SYBU
syntabulin (syntaxin-interacting)
chr3_-_71592707 2.074 NM_001244816
FOXP1
forkhead box P1
chr4_+_30721865 2.065 NM_032456
NM_001173523
NM_002589
NM_032457
PCDH7



protocadherin 7



chr15_+_36932805 2.046 NM_032499
C15orf41
chromosome 15 open reading frame 41
chr12_-_10021932 2.042 CLEC2B
C-type lectin domain family 2, member B
chr7_-_137028533 1.989 NM_002825
PTN
pleiotrophin
chr12_+_49741040 1.925 NM_024902
DNAJC22
DnaJ (Hsp40) homolog, subfamily C, member 22
chr5_+_140710203 1.911 NM_018912
NM_031993
PCDHGA1

protocadherin gamma subfamily A, 1

chr4_+_30722191 1.904 PCDH7
protocadherin 7
chr5_-_111091947 1.890 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr4_-_99851785 1.886 NM_001130679
NM_001968
EIF4E

eukaryotic translation initiation factor 4E

chr3_-_71179736 1.874 FOXP1
forkhead box P1
chr1_+_157963062 1.873 NM_018240
KIRREL
kin of IRRE like (Drosophila)
chr14_+_32798478 1.866 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chr1_+_209757044 1.824 NM_020439
CAMK1G
calcium/calmodulin-dependent protein kinase IG
chr11_+_101983170 1.814 NM_001195045
YAP1
Yes-associated protein 1
chr2_-_216242916 1.793 FN1
fibronectin 1
chr13_+_24144402 1.788 NM_001204459
NM_148957
TNFRSF19

tumor necrosis factor receptor superfamily, member 19

chr3_-_71179715 1.781 FOXP1
forkhead box P1
chr2_-_65593866 1.735 NM_001128210
SPRED2
sprouty-related, EVH1 domain containing 2
chr9_-_27297106 1.723 NM_001161585
NM_020641
C9orf11

chromosome 9 open reading frame 11

chr7_-_111428944 1.705 DOCK4
dedicator of cytokinesis 4
chr5_-_16742336 1.695 MYO10
myosin X
chr10_+_45406629 1.684 NM_001123376
TMEM72
transmembrane protein 72
chr5_-_131879172 1.656 NM_000879
IL5
interleukin 5 (colony-stimulating factor, eosinophil)
chr2_+_166326156 1.644 NM_001172173
CSRNP3
cysteine-serine-rich nuclear protein 3
chr13_-_38172862 1.643 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr7_-_83824216 1.639 NM_006080
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr4_-_40936640 1.632 APBB2
amyloid beta (A4) precursor protein-binding, family B, member 2
chr12_-_89745997 1.632 DUSP6
dual specificity phosphatase 6
chr1_-_109399705 1.623 NM_152763
AKNAD1
AKNA domain containing 1
chr11_-_57417247 1.604 NM_145008
YPEL4
yippee-like 4 (Drosophila)
chr12_-_52886971 1.595 NM_005554
KRT6A
keratin 6A
chr20_-_30539803 1.588 PDRG1
p53 and DNA-damage regulated 1
chr1_-_153123426 1.559 NM_001014291
SPRR2G
small proline-rich protein 2G
chr5_+_55149149 1.549 NM_001242636
NM_001242639
IL31RA

interleukin 31 receptor A

chr1_-_154164551 1.547 NM_152263
TPM3
tropomyosin 3
chr1_+_152943127 1.536 NM_173080
SPRR4
small proline-rich protein 4
chr8_-_109799769 1.512 NM_153015
TMEM74
transmembrane protein 74
chr15_+_77287738 1.509 PSTPIP1
proline-serine-threonine phosphatase interacting protein 1
chr6_-_13408368 1.506 NM_001242630
GFOD1
glucose-fructose oxidoreductase domain containing 1
chrX_+_17653412 1.497 NM_001136024
NHS
Nance-Horan syndrome (congenital cataracts and dental anomalies)
chr12_+_21679190 1.495 NM_030572
C12orf39
chromosome 12 open reading frame 39
chr5_+_34687663 1.493 NM_001145523
RAI14
retinoic acid induced 14
chr4_-_176733901 1.487 GPM6A
glycoprotein M6A
chr1_+_84630374 1.481 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr1_+_153190059 1.472 NM_001195571
PRR9
proline rich 9
chr7_+_28725597 1.468 NM_001011666
CREB5
cAMP responsive element binding protein 5
chr2_-_65593763 1.460 SPRED2
sprouty-related, EVH1 domain containing 2
chr7_-_20256942 1.436 NM_182762
MACC1
metastasis associated in colon cancer 1
chr2_-_31352489 1.431 NM_001253827
GALNT14
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)
chr2_-_40739570 1.425 NM_001112802
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr1_-_222763081 1.419 NM_001201536
NM_005681
NM_139352
TAF1A


TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa


chr1_-_183560010 1.417 NM_001127651
NCF2
neutrophil cytosolic factor 2
chr12_+_47610051 1.410 NM_138371
FAM113B
family with sequence similarity 113, member B
chr11_+_12308446 1.401 NM_032867
MICALCL
MICAL C-terminal like
chr1_+_153003677 1.397 NM_003125
SPRR1B
small proline-rich protein 1B
chrX_-_19688991 1.389 NM_001184960
SH3KBP1
SH3-domain kinase binding protein 1
chr6_+_36973409 1.367 NM_173558
FGD2
FYVE, RhoGEF and PH domain containing 2
chr2_+_102508377 1.361 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr1_+_35246789 1.358 NM_024009
GJB3
gap junction protein, beta 3, 31kDa
chr14_+_67831484 1.356 EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr7_+_29519485 1.343 NM_001039936
CHN2
chimerin (chimaerin) 2
chr7_+_114066554 1.327 NM_001172767
NM_148899
FOXP2

forkhead box P2

chr1_-_183387501 1.324 NM_015039
NMNAT2
nicotinamide nucleotide adenylyltransferase 2
chr19_-_43032525 1.309 NM_001024912
NM_001184813
NM_001184815
NM_001184816
NM_001205344
NM_001712
CEACAM1





carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)





chr20_-_34243118 1.296 RBM12
RNA binding motif protein 12
chr11_+_118398147 1.282 NM_001080441
TTC36
tetratricopeptide repeat domain 36
chr1_+_87012758 1.278 NM_012128
CLCA4
chloride channel accessory 4
chr12_+_49740688 1.263 DNAJC22
DnaJ (Hsp40) homolog, subfamily C, member 22
chr15_-_56388662 1.257 RFX7
regulatory factor X, 7
chr9_-_28719302 1.254 NM_152570
LINGO2
leucine rich repeat and Ig domain containing 2
chr19_+_16244837 1.253 NM_032855
HSH2D
hematopoietic SH2 domain containing
chr11_-_7727940 1.246 NM_198185
OVCH2
ovochymase 2 (gene/pseudogene)
chr4_+_71384289 1.238 NM_212557
AMTN
amelotin
chrX_+_135614310 1.232 NM_016267
VGLL1
vestigial like 1 (Drosophila)
chr4_-_68749698 1.232 NM_004262
TMPRSS11D
transmembrane protease, serine 11D
chr5_+_140625146 1.229 NM_018935
PCDHB15
protocadherin beta 15
chr13_+_49684388 1.228 NM_014923
FNDC3A
fibronectin type III domain containing 3A
chr1_-_93257950 1.220 NM_005665
EVI5
ecotropic viral integration site 5
chr6_-_119252887 1.211 NM_017696
MCM9
minichromosome maintenance complex component 9
chr10_-_75401199 1.205 MYOZ1
myozenin 1
chr5_+_140809957 1.205 PCDHGA12
protocadherin gamma subfamily A, 12
chr4_+_77953942 1.204 SEPT11
septin 11
chr22_-_45608346 1.204 NM_015264
KIAA0930
KIAA0930
chr21_-_36421195 1.193 RUNX1
runt-related transcription factor 1
chr16_+_20775311 1.178 NM_005622
NM_202000
ACSM3

acyl-CoA synthetase medium-chain family member 3

chr12_-_50616425 1.175 NM_001113547
LIMA1
LIM domain and actin binding 1
chr6_-_46293215 1.172 RCAN2
regulator of calcineurin 2
chr2_+_102508333 1.166 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr2_+_182321618 1.160 NM_000885
ITGA4
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
3.85 3.38e-07 GO:0007155 cell adhesion
3.85 3.38e-07 GO:0022610 biological adhesion
1.98 4.36e-07 GO:0032502 developmental process
9.02 1.71e-06 GO:0007156 homophilic cell adhesion
1.97 6.04e-06 GO:0007275 multicellular organismal development
2.11 6.07e-06 GO:0048731 system development
2.02 7.57e-06 GO:0048856 anatomical structure development
5.54 1.03e-05 GO:0016337 cell-cell adhesion
6.22 1.49e-04 GO:0008544 epidermis development
15.14 2.70e-04 GO:0031424 keratinization
3.04 3.36e-04 GO:0009888 tissue development
2.19 3.42e-04 GO:0030154 cell differentiation
11.35 3.85e-04 GO:0030216 keratinocyte differentiation
2.13 7.30e-04 GO:0048869 cellular developmental process
9.82 1.19e-03 GO:0009913 epidermal cell differentiation
5.71 3.05e-03 GO:0030855 epithelial cell differentiation
1.54 6.52e-03 GO:0032501 multicellular organismal process

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
25.95 1.13e-05 GO:0001533 cornified envelope
1.86 1.40e-02 GO:0005576 extracellular region
12.98 3.44e-02 GO:0001725 stress fiber
12.11 4.52e-02 GO:0032432 actin filament bundle

Nothing significant found in function category.