Motif ID: NKX2-2,8.p2

Z-value: 1.322


Transcription factors associated with NKX2-2,8.p2:

Gene SymbolEntrez IDGene Name
NKX2-2 4821 NK2 homeobox 2
NKX2-8 26257 NK2 homeobox 8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NKX2-2hg19_v1_chr20_-_21494663_21494663-0.694.8e-12Click!
NKX2-8hg19_v1_chr14_-_37051785_370518110.244.0e-02Click!


Activity profile for motif NKX2-2,8.p2.

activity profile for motif NKX2-2,8.p2


Sorted Z-values histogram for motif NKX2-2,8.p2

Sorted Z-values for motif NKX2-2,8.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-2,8.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_38171613 19.031 NM_000759
NM_001178147
NM_172219
NM_172220
CSF3



colony stimulating factor 3 (granulocyte)



chr2_+_102953716 11.298 NM_003856
IL1RL1
interleukin 1 receptor-like 1
chr12_-_91573264 10.291 NM_133503
DCN
decorin
chr21_-_15918635 8.692 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr19_-_44174497 8.468 NM_001005376
NM_001005377
NM_002659
PLAUR


plasminogen activator, urokinase receptor


chr4_+_95376396 8.027 PDLIM5
PDZ and LIM domain 5
chr6_+_151561508 7.990 AKAP12
A kinase (PRKA) anchor protein 12
chr3_+_158991035 7.794 NM_001197107
NM_001197108
NM_014575
SCHIP1


schwannomin interacting protein 1


chr3_+_158991090 7.127 SCHIP1
schwannomin interacting protein 1
chr7_-_107880492 7.072 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr6_+_151561571 7.011


chr3_-_44489718 6.288


chr8_-_133772808 5.881 NM_001145153
NM_144649
TMEM71

transmembrane protein 71

chr9_-_85882093 5.379 NM_001244962
FRMD3
FERM domain containing 3
chr17_-_67138013 5.270 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr1_-_153085963 5.228 NM_001014450
SPRR2A
SPRR2F
small proline-rich protein 2A
small proline-rich protein 2F
chr2_+_228356287 5.219 AGFG1
ArfGAP with FG repeats 1
chr5_+_71502700 4.612 MAP1B
microtubule-associated protein 1B
chr17_+_18647325 4.542 NM_031456
FBXW10
F-box and WD repeat domain containing 10
chr2_+_183582667 4.533 DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr2_-_224467049 4.529 SCG2
secretogranin II
chr2_-_225370687 4.311 CUL3
cullin 3
chr2_-_216300444 4.289 FN1
fibronectin 1
chr12_-_105322056 4.275 NM_032148
SLC41A2
solute carrier family 41, member 2
chr11_+_36397534 4.132 NM_001160168
NM_024841
PRR5L

proline rich 5 like

chr17_-_29641094 4.118 NM_006495
EVI2B
ecotropic viral integration site 2B
chr19_-_14889347 4.061 NM_013447
NM_152916
NM_152917
NM_152918
NM_152919
NM_152920
NM_152921
EMR2






egf-like module containing, mucin-like, hormone receptor-like 2






chr1_+_244214552 4.035 NM_205768
ZNF238
zinc finger protein 238
chr3_-_112359251 4.018 CCDC80
coiled-coil domain containing 80
chr19_-_44174271 3.984 PLAUR
plasminogen activator, urokinase receptor
chr5_+_125758818 3.965 NM_001146320
NM_001146321
NM_023927
GRAMD3


GRAM domain containing 3


chr12_+_78225068 3.936 NM_014903
NAV3
neuron navigator 3
chr3_+_151531860 3.927 NM_001086
AADAC
arylacetamide deacetylase (esterase)
chr10_-_98336445 3.918 TM9SF3
transmembrane 9 superfamily member 3
chr3_+_119013216 3.907 NM_020754
ARHGAP31
Rho GTPase activating protein 31
chr15_+_80390757 3.873 NM_001242919
ZFAND6
zinc finger, AN1-type domain 6
chr19_-_55580896 3.841 NM_138412
RDH13
retinol dehydrogenase 13 (all-trans/9-cis)
chr1_+_244214576 3.812 ZNF238
zinc finger protein 238
chr1_-_244006471 3.761 NM_005465
NM_181690
AKT3

v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)

chr5_+_159656436 3.676 NM_001445
FABP6
fatty acid binding protein 6, ileal
chr4_+_75174189 3.652 NM_001013442
EPGN
epithelial mitogen homolog (mouse)
chr3_-_15839674 3.638 NM_001195098
ANKRD28
ankyrin repeat domain 28
chr6_-_138820580 3.613


chr12_+_121132677 3.545


chr9_+_130026755 3.541 NM_032293
GARNL3
GTPase activating Rap/RanGAP domain-like 3
chrX_-_13397504 3.533


chr17_+_57743498 3.514 CLTC
clathrin, heavy chain (Hc)
chr6_-_73935174 3.495 NM_001126063
KHDC1L
KH homology domain containing 1-like
chr11_-_47510518 3.443 NM_001025596
NM_001172640
CELF1

CUGBP, Elav-like family member 1

chr3_-_112359277 3.433 CCDC80
coiled-coil domain containing 80
chr9_+_112887780 3.433 NM_001136562
AKAP2
A kinase (PRKA) anchor protein 2
chr7_+_112092112 3.353 NM_001197079
IFRD1
interferon-related developmental regulator 1
chr11_-_18258315 3.280 SAA4
serum amyloid A4, constitutive
chr13_-_49975734 3.267 NM_030925
CAB39L
calcium binding protein 39-like
chrX_+_108779009 3.237 NM_018698
NXT2
nuclear transport factor 2-like export factor 2
chr2_-_31352489 3.220 NM_001253827
GALNT14
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)
chrX_-_19817854 3.186 SH3KBP1
SH3-domain kinase binding protein 1
chr3_-_57326709 3.162 NM_001142733
ASB14
ankyrin repeat and SOCS box containing 14
chr3_+_157154579 3.130 NM_002852
PTX3
pentraxin 3, long
chr15_+_52201590 3.125 TMOD3
tropomodulin 3 (ubiquitous)
chr18_+_55888838 3.066 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr1_-_244006885 3.054 NM_001206729
AKT3
v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
chr19_-_55767103 3.038 PPP6R1
protein phosphatase 6, regulatory subunit 1
chrX_-_118726852 3.021 NM_001173488
NKRF
NFKB repressing factor
chr10_+_123754141 2.996 TACC2
transforming, acidic coiled-coil containing protein 2
chr8_+_66582107 2.988 NM_001145838
MTFR1
mitochondrial fission regulator 1
chr18_+_55888799 2.969 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr2_-_225378320 2.959 CUL3
cullin 3
chr8_-_42065193 2.937 NM_000930
NM_033011
PLAT

plasminogen activator, tissue

chrX_-_19817907 2.934 NM_001024666
SH3KBP1
SH3-domain kinase binding protein 1
chr9_-_21482311 2.931 NM_176891
IFNE
interferon, epsilon
chr6_+_142510627 2.917 VTA1
Vps20-associated 1 homolog (S. cerevisiae)
chr2_+_102803432 2.901 NM_003854
IL1RL2
interleukin 1 receptor-like 2
chr19_+_13134782 2.890 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr14_-_75600111 2.875 TMED10
transmembrane emp24-like trafficking protein 10 (yeast)
chr1_+_162602198 2.871 NM_001014796
NM_006182
DDR2

discoidin domain receptor tyrosine kinase 2

chr8_-_145770680 2.866 ARHGAP39
Rho GTPase activating protein 39
chr4_-_76957139 2.840 NM_005409
CXCL11
chemokine (C-X-C motif) ligand 11
chr18_+_55888750 2.827 NM_001144966
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr5_+_42756919 2.807 NM_001134848
CCDC152
coiled-coil domain containing 152
chr8_+_26150731 2.788 NM_001177591
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr5_-_98262217 2.775 NM_001270
CHD1
chromodomain helicase DNA binding protein 1
chr2_-_216248184 2.760 FN1
fibronectin 1
chr1_+_104159953 2.757 NM_000699
AMY2A
amylase, alpha 2A (pancreatic)
chr12_+_64803741 2.734 XPOT
exportin, tRNA (nuclear export receptor for tRNAs)
chr8_-_145642250 2.686 NM_130849
SLC39A4
solute carrier family 39 (zinc transporter), member 4
chr4_-_170077807 2.653 SH3RF1
SH3 domain containing ring finger 1
chr9_+_103340335 2.642 NM_001018116
MURC
muscle-related coiled-coil protein
chr8_+_124194873 2.588 FAM83A
family with sequence similarity 83, member A
chr1_+_15272414 2.570 NM_001017999
KAZN
kazrin, periplakin interacting protein
chr10_+_5136613 2.566 AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr12_-_90049818 2.551 NM_001001323
NM_001682
ATP2B1

ATPase, Ca++ transporting, plasma membrane 1

chr7_+_28475233 2.549 NM_004904
CREB5
cAMP responsive element binding protein 5
chr11_+_12960793 2.541 TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr8_+_17396285 2.531 NM_001164771
NM_003046
SLC7A2

solute carrier family 7 (cationic amino acid transporter, y+ system), member 2

chr13_-_46756326 2.518 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr9_+_131447364 2.517 NM_001248000
SET
SET nuclear oncogene
chr1_+_241695433 2.493 NM_003679
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr9_+_96233420 2.478 FAM120A
family with sequence similarity 120A
chr1_-_232651227 2.477 NM_020808
SIPA1L2
signal-induced proliferation-associated 1 like 2
chr1_-_242612757 2.477 NM_001195811
NM_001195812
PLD5

phospholipase D family, member 5

chr14_-_100841656 2.446 WARS
tryptophanyl-tRNA synthetase
chr14_+_96846021 2.439 NM_016472
C14orf129
chromosome 14 open reading frame 129
chr5_-_137848517 2.433 ETF1
eukaryotic translation termination factor 1
chr6_+_158733691 2.429 NM_001007466
NM_020245
TULP4

tubby like protein 4

chr16_+_56815703 2.422 NM_001242795
NUP93
nucleoporin 93kDa
chr8_-_57233240 2.417 NM_138969
SDR16C5
short chain dehydrogenase/reductase family 16C, member 5
chr12_-_52779362 2.410 NM_033045
KRT84
keratin 84
chr2_-_216245573 2.385 FN1
fibronectin 1
chr3_+_152017193 2.384 NM_207293
NM_207294
NM_207295
NM_207296
NM_207297
MBNL1




muscleblind-like (Drosophila)




chr9_+_96846710 2.376 NM_001253829
NM_152422
PTPDC1

protein tyrosine phosphatase domain containing 1

chr21_+_35190586 2.353 ITSN1
intersectin 1 (SH3 domain protein)
chr4_+_41614911 2.344 NM_001112719
NM_001112720
LIMCH1

LIM and calponin homology domains 1

chr15_-_56209305 2.332 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr17_-_1248346 2.326 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr4_-_110723127 2.281 CFI
complement factor I
chr1_+_15990300 2.275


chr2_+_102508377 2.267 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr14_+_67831484 2.263 EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr6_+_28249313 2.244 NM_001184743
NM_032507
PGBD1

piggyBac transposable element derived 1

chr17_-_29641087 2.234 EVI2B
ecotropic viral integration site 2B
chr8_-_42065037 2.226 PLAT
plasminogen activator, tissue
chrX_+_129139163 2.219 NM_021946
BCORL1
BCL6 corepressor-like 1
chr5_+_139505519 2.212 NM_001007189
IGIP
IgA-inducing protein homolog (Bos taurus)
chr8_-_38205652 2.205 WHSC1L1
Wolf-Hirschhorn syndrome candidate 1-like 1
chr1_-_207095198 2.177 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr9_+_115631814 2.164 SNX30
sorting nexin family member 30
chr4_+_41614933 2.151 LIMCH1
LIM and calponin homology domains 1
chr3_-_112359863 2.142 CCDC80
coiled-coil domain containing 80
chr1_+_215178884 2.124 NM_001017424
KCNK2
potassium channel, subfamily K, member 2
chr11_+_33563772 2.122 NM_012194
C11orf41
chromosome 11 open reading frame 41
chr6_-_119252887 2.115 NM_017696
MCM9
minichromosome maintenance complex component 9
chr1_-_51887740 2.076 NM_001159969
EPS15
epidermal growth factor receptor pathway substrate 15
chr9_+_79056581 2.075 NM_001097634
GCNT1
glucosaminyl (N-acetyl) transferase 1, core 2
chr3_-_119582422 2.073 GSK3B
glycogen synthase kinase 3 beta
chr8_-_145642226 2.073 SLC39A4
solute carrier family 39 (zinc transporter), member 4
chr2_+_102508333 2.071 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr4_-_99851785 2.056 NM_001130679
NM_001968
EIF4E

eukaryotic translation initiation factor 4E

chr17_-_29641068 2.053 EVI2B
ecotropic viral integration site 2B
chr10_+_5005601 2.032 AKR1C1
AKR1C3
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr5_-_150521200 2.026 NM_001193544
ANXA6
annexin A6
chr3_+_44692500 2.024 ZNF35
zinc finger protein 35
chr10_+_5005685 2.006 AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr15_-_55563091 2.005 NM_183236
RAB27A
RAB27A, member RAS oncogene family
chr5_+_147774274 1.991 FBXO38
F-box protein 38
chr2_-_191872322 1.986 STAT1
signal transducer and activator of transcription 1, 91kDa
chr5_+_68800003 1.979 NM_001205255
OCLN
occludin
chr9_+_125132823 1.977 PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr14_-_100841793 1.970 WARS
tryptophanyl-tRNA synthetase
chr3_-_186262114 1.967 NM_017541
CRYGS
crystallin, gamma S
chr8_+_124194751 1.964 NM_032899
NM_207006
FAM83A

family with sequence similarity 83, member A

chr1_+_167298280 1.960 NM_001198783
POU2F1
POU class 2 homeobox 1
chr10_+_35484054 1.957 NM_182717
NM_182718
NM_182719
NM_182720
CREM



cAMP responsive element modulator



chr1_+_171481164 1.956 PRRC2C
proline-rich coiled-coil 2C
chr22_+_20377668 1.933 NM_001242313
TMEM191B
transmembrane protein 191B
chr18_-_29993195 1.903


chr5_+_125759076 1.898 GRAMD3
GRAM domain containing 3
chr3_-_112359565 1.893 CCDC80
coiled-coil domain containing 80
chr17_+_26794838 1.866


chr3_+_88188261 1.860 NM_018293
ZNF654
zinc finger protein 654
chr10_+_5005453 1.846 NM_001353
AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr12_-_46633551 1.832 SLC38A1
solute carrier family 38, member 1
chr12_-_28124915 1.829 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr10_+_35456443 1.826 NM_182771
NM_182772
CREM

cAMP responsive element modulator

chrX_+_11777734 1.823 NM_006800
MSL3
male-specific lethal 3 homolog (Drosophila)
chr12_-_50616425 1.821 NM_001113547
LIMA1
LIM domain and actin binding 1
chr15_-_55652777 1.815 CCPG1
cell cycle progression 1
chrX_+_107683015 1.810 NM_000495
NM_033380
COL4A5

collagen, type IV, alpha 5

chr1_-_41627045 1.800 NM_001031694
SCMH1
sex comb on midleg homolog 1 (Drosophila)
chr3_-_112359660 1.796 CCDC80
coiled-coil domain containing 80
chr5_-_139937677 1.776 NM_001035235
SRA1
steroid receptor RNA activator 1
chr6_+_4890225 1.771 NM_001143971
CDYL
chromodomain protein, Y-like
chr19_-_16242996 1.765


chrM_+_4465 1.760


chr12_-_10588543 1.756 NM_002260
KLRC2
KLRC3
killer cell lectin-like receptor subfamily C, member 2
killer cell lectin-like receptor subfamily C, member 3
chr15_-_69707358 1.755 LOC145694
uncharacterized LOC145694
chr2_-_224467095 1.751 SCG2
secretogranin II
chr3_+_63953419 1.748 NM_001128149
ATXN7
ataxin 7
chr9_+_120466625 1.728 TLR4
toll-like receptor 4
chr17_-_79478236 1.726 ACTG1
actin, gamma 1
chr18_+_19353635 1.722 MIB1
mindbomb homolog 1 (Drosophila)
chr12_+_65224214 1.720


chr3_+_51575595 1.718 NM_015106
RAD54L2
RAD54-like 2 (S. cerevisiae)
chr13_+_111855406 1.717 ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chrM_+_4770 1.705


chr3_-_196911001 1.702 NM_001204387
NM_001204388
DLG1

discs, large homolog 1 (Drosophila)

chr7_-_120498128 1.701 NM_012338
TSPAN12
tetraspanin 12
chr4_-_84035908 1.700 NM_001130715
NM_016619
PLAC8

placenta-specific 8

chr4_+_71384289 1.692 NM_212557
AMTN
amelotin
chr10_-_14816895 1.684 NM_031453
FAM107B
family with sequence similarity 107, member B
chr14_+_89060729 1.682 NM_207662
ZC3H14
zinc finger CCCH-type containing 14
chr21_+_30400229 1.659 USP16
ubiquitin specific peptidase 16
chr13_-_99630243 1.651 NM_001130048
NM_001130050
DOCK9

dedicator of cytokinesis 9

chr4_+_153864134 1.648 NM_033393
FHDC1
FH2 domain containing 1
chr3_-_112359547 1.646 CCDC80
coiled-coil domain containing 80
chr12_-_121736110 1.643 NM_006549
NM_153499
NM_153500
NM_172214
NM_172215
NM_172216
CAMKK2





calcium/calmodulin-dependent protein kinase kinase 2, beta





chr4_-_110723334 1.633 NM_000204
CFI
complement factor I
chr14_-_95608054 1.630 NM_030621
DICER1
dicer 1, ribonuclease type III
chr1_+_53480573 1.623 NM_001007099
NM_001007100
NM_001007250
SCP2


sterol carrier protein 2


chr16_-_89349696 1.623 ANKRD11
ankyrin repeat domain 11

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
16.71 9.46e-03 GO:0051017 actin filament bundle assembly
1.77 3.35e-02 GO:0030154 cell differentiation
1.76 3.42e-02 GO:0048869 cellular developmental process

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
1.31 6.10e-03 GO:0005515 protein binding