Motif ID: NKX2-1,4.p2

Z-value: 0.727


Transcription factors associated with NKX2-1,4.p2:

Gene SymbolEntrez IDGene Name
NKX2-1 7080 NK2 homeobox 1
NKX2-4 644524 NK2 homeobox 4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NKX2-1hg19_v1_chr14_-_36988902_369889020.142.4e-01Click!
NKX2-4hg19_v1_chr20_-_21378046_213781820.123.1e-01Click!


Activity profile for motif NKX2-1,4.p2.

activity profile for motif NKX2-1,4.p2


Sorted Z-values histogram for motif NKX2-1,4.p2

Sorted Z-values for motif NKX2-1,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-1,4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr21_-_15918635 5.115 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr19_-_6670598 4.919 NM_003807
NM_172014
TNFSF14

tumor necrosis factor (ligand) superfamily, member 14

chr10_+_70980058 4.050 NM_025130
HKDC1
hexokinase domain containing 1
chr10_+_123754141 3.886 TACC2
transforming, acidic coiled-coil containing protein 2
chr2_+_29038862 3.314 NM_001008779
SPDYA
speedy homolog A (Xenopus laevis)
chr4_-_185726865 2.980 ACSL1
acyl-CoA synthetase long-chain family member 1
chr17_+_7905911 2.590 NM_000180
GUCY2D
guanylate cyclase 2D, membrane (retina-specific)
chr15_-_31523049 2.145 NM_001243538
LOC283710
uncharacterized LOC283710
chr2_+_28616346 1.999 FOSL2
FOS-like antigen 2
chr2_+_28616360 1.830 FOSL2
FOS-like antigen 2
chr2_+_28615695 1.829 FOSL2
FOS-like antigen 2
chr2_-_188419185 1.680 NM_001032281
NM_006287
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chr12_-_53600999 1.668 NM_000889
ITGB7
integrin, beta 7
chr2_-_133539627 1.618 NCKAP5
NCK-associated protein 5
chr17_-_39211462 1.602 NM_033032
KRTAP2-2
keratin associated protein 2-2
chr7_+_94539209 1.542 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory subunit 9A


chr15_+_74466024 1.455 NM_005545
ISLR
immunoglobulin superfamily containing leucine-rich repeat
chr2_+_28615771 1.374 NM_005253
FOSL2
FOS-like antigen 2
chr19_-_55767103 1.355 PPP6R1
protein phosphatase 6, regulatory subunit 1
chr9_+_103340335 1.305 NM_001018116
MURC
muscle-related coiled-coil protein
chr15_-_74500394 1.170 NM_001199041
STRA6
stimulated by retinoic acid gene 6 homolog (mouse)
chr2_+_28615668 1.136 FOSL2
FOS-like antigen 2
chr8_-_93115453 1.101 NM_001198633
NM_175634
RUNX1T1

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

chr10_-_49482912 1.072 NM_001018071
FRMPD2
FERM and PDZ domain containing 2
chr19_+_41105573 1.066 LTBP4
latent transforming growth factor beta binding protein 4
chr1_+_61869699 1.058 NFIA
nuclear factor I/A
chr1_-_33813261 1.033


chr5_+_32173481 1.030 LOC153546
uncharacterized LOC153546
chr19_-_6670078 1.020 TNFSF14
tumor necrosis factor (ligand) superfamily, member 14
chr19_-_40440532 1.013 NM_003890
FCGBP
Fc fragment of IgG binding protein
chr3_+_68053358 0.998 NM_213609
FAM19A1
family with sequence similarity 19 (chemokine (C-C motif)-like), member A1
chr11_+_66395733 0.989


chr4_-_122085475 0.962 NM_024873
TNIP3
TNFAIP3 interacting protein 3
chr17_-_39222126 0.959 NM_033184
KRTAP2-4
keratin associated protein 2-4
chr3_+_158991090 0.952 SCHIP1
schwannomin interacting protein 1
chr1_-_240775448 0.923 NM_022469
GREM2
gremlin 2
chr10_-_104211244 0.912 NM_024886
C10orf95
chromosome 10 open reading frame 95
chr16_+_12058963 0.906 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr14_+_64682671 0.903 NM_182910
SYNE2
spectrin repeat containing, nuclear envelope 2
chr4_+_102734982 0.878 NM_001083907
BANK1
B-cell scaffold protein with ankyrin repeats 1
chr1_-_41625539 0.867 NM_001172222
SCMH1
sex comb on midleg homolog 1 (Drosophila)
chr14_+_39703119 0.862 NM_054024
MIA2
melanoma inhibitory activity 2
chr10_-_75335415 0.844 NM_152586
USP54
ubiquitin specific peptidase 54
chr12_+_109826523 0.840 NM_001101421
MYO1H
myosin IH
chr10_-_127464389 0.837 NM_147191
MMP21
matrix metallopeptidase 21
chrX_-_15402469 0.832 NM_004469
FIGF
c-fos induced growth factor (vascular endothelial growth factor D)
chr1_-_23696267 0.826 NM_001077195
ZNF436
zinc finger protein 436
chr6_+_126240369 0.814 NM_001199622
NCOA7
nuclear receptor coactivator 7
chr1_-_110155672 0.808 NM_005272
GNAT2
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
chrX_-_110655384 0.804 NM_178151
NM_001195553
NM_178152
NM_178153
DCX



doublecortin



chr17_-_3461030 0.772 TRPV3
transient receptor potential cation channel, subfamily V, member 3
chr12_-_53601051 0.770 ITGB7
integrin, beta 7
chr19_-_55668956 0.756 NM_000363
TNNI3
troponin I type 3 (cardiac)
chr6_+_30951484 0.754 NM_001010909
MUC21
mucin 21, cell surface associated
chr15_+_74466171 0.751 ISLR
immunoglobulin superfamily containing leucine-rich repeat
chr6_+_152011630 0.748 NM_001122742
ESR1
estrogen receptor 1
chr1_-_108231122 0.746 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr2_-_50574891 0.739 NM_138735
NRXN1
neurexin 1
chr12_+_62954275 0.726 MON2
MON2 homolog (S. cerevisiae)
chr16_+_3062456 0.710 NM_020982
CLDN9
claudin 9
chr1_-_217250230 0.697 NM_001243507
NM_001243509
ESRRG

estrogen-related receptor gamma

chr20_+_4702499 0.681 NM_012409
PRND
prion protein 2 (dublet)
chr8_-_30706532 0.677 NM_031271
TEX15
testis expressed 15
chrX_+_48542159 0.669 NM_000377
WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr3_-_48671278 0.665 NM_001040454
SLC26A6
solute carrier family 26, member 6
chr2_-_188419049 0.654 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr16_-_81253974 0.646 NM_001076780
NM_052892
PKD1L2

polycystic kidney disease 1-like 2

chr7_+_129847699 0.642 NM_145268
C7orf45
chromosome 7 open reading frame 45
chr5_-_88119604 0.633 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr4_+_90033967 0.624 NM_145715
TIGD2
tigger transposable element derived 2
chr9_+_140119643 0.614 NM_199001
C9orf169
chromosome 9 open reading frame 169
chr7_+_129932973 0.614 NM_001163446
NM_016352
CPA4

carboxypeptidase A4

chr18_-_45663667 0.613 NM_001039360
ZBTB7C
zinc finger and BTB domain containing 7C
chr5_-_160279045 0.604 NM_025153
ATP10B
ATPase, class V, type 10B
chr1_+_153232178 0.597 NM_000427
LOR
loricrin
chr5_+_156820161 0.591 CYFIP2
cytoplasmic FMR1 interacting protein 2
chr4_+_189060597 0.577 NM_178556
TRIML1
tripartite motif family-like 1
chr2_+_162272619 0.574 NM_006593
TBR1
T-box, brain, 1
chr11_-_119252364 0.560 NM_001243759
NM_004205
USP2

ubiquitin specific peptidase 2

chr4_+_37962055 0.560 NM_006607
PTTG2
pituitary tumor-transforming 2
chr12_-_54778298 0.558 ZNF385A
zinc finger protein 385A
chr11_-_66675334 0.552 NM_022172
PC
pyruvate carboxylase
chrX_+_48542193 0.552 WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr17_-_66951381 0.550 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr17_-_3461288 0.550 NM_145068
TRPV3
transient receptor potential cation channel, subfamily V, member 3
chr21_+_38792600 0.542 NM_130438
NM_001396
DYRK1A

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A

chr10_+_114154522 0.535 ACSL5
acyl-CoA synthetase long-chain family member 5
chr15_-_31947541 0.530 NM_130901
OTUD7A
OTU domain containing 7A
chr10_+_114135013 0.524 NM_203380
ACSL5
acyl-CoA synthetase long-chain family member 5
chr17_+_18647325 0.522 NM_031456
FBXW10
F-box and WD repeat domain containing 10
chrX_+_41583407 0.519 NM_080817
GPR82
G protein-coupled receptor 82
chr7_-_99332715 0.515 NM_000765
CYP3A7
CYP3A5
cytochrome P450, family 3, subfamily A, polypeptide 7
cytochrome P450, family 3, subfamily A, polypeptide 5
chr13_+_46276445 0.514 NM_152719
SPERT
spermatid associated
chrX_+_70765479 0.510 OGT
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
chr17_-_15523017 0.506 NM_006382
CDRT1
CMT1A duplicated region transcript 1
chr6_+_154897419 0.503


chr4_+_114214102 0.502 ANK2
ankyrin 2, neuronal
chr14_-_76447445 0.501 TGFB3
transforming growth factor, beta 3
chr6_+_31949800 0.500 NM_001242823
NM_001252204
NM_007293
NM_001002029
LOC100293534
C4A

C4B
complement C4-B-like
complement component 4A (Rodgers blood group)

complement component 4B (Chido blood group)
chr4_+_72204769 0.499 NM_003759
SLC4A4
solute carrier family 4, sodium bicarbonate cotransporter, member 4
chr18_+_52258389 0.498 NM_173629
C18orf26
chromosome 18 open reading frame 26
chr1_+_226012974 0.493 NM_000120
EPHX1
epoxide hydrolase 1, microsomal (xenobiotic)
chr4_-_69111333 0.492 NM_182502
TMPRSS11B
transmembrane protease, serine 11B
chr10_+_102222797 0.485 NM_003393
WNT8B
wingless-type MMTV integration site family, member 8B
chr11_+_64018991 0.484 NM_000932
NM_001184883
PLCB3

phospholipase C, beta 3 (phosphatidylinositol-specific)

chr3_-_187009469 0.481 NM_001031849
NM_001879
NM_139125
MASP1


mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)


chr2_+_234590583 0.478 NM_019077
UGT1A7
UDP glucuronosyltransferase 1 family, polypeptide A7
chrX_-_132162297 0.477 NM_031907
USP26
ubiquitin specific peptidase 26
chr19_-_49258646 0.474 NM_000148
FUT1
fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
chr15_-_83474805 0.470 NM_001007122
FSD2
fibronectin type III and SPRY domain containing 2
chr12_-_121248679 0.463 SPPL3
signal peptide peptidase-like 3
chrX_+_47082416 0.463 NM_001170460
CDK16
cyclin-dependent kinase 16
chr7_-_107443631 0.457 NM_000111
SLC26A3
solute carrier family 26, member 3
chr2_+_169929009 0.456 NM_001142270
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr2_-_163695028 0.456 KCNH7
potassium voltage-gated channel, subfamily H (eag-related), member 7
chr18_+_55862577 0.453 NM_001144970
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr1_+_182569427 0.450


chr1_+_152483319 0.449 NM_178438
LCE5A
late cornified envelope 5A
chr14_+_39734475 0.445 NM_203354
CTAGE5
CTAGE family, member 5
chr1_-_161059353 0.443 NM_030916
PVRL4
poliovirus receptor-related 4
chr11_+_62439134 0.437 C11orf83
chromosome 11 open reading frame 83
chr5_-_87969135 0.430 LINC00461
long intergenic non-protein coding RNA 461
chr5_-_131879172 0.429 NM_000879
IL5
interleukin 5 (colony-stimulating factor, eosinophil)
chr3_-_141747434 0.427 NM_001178141
NM_001178142
NM_006286
TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr2_-_163695239 0.426 NM_033272
NM_173162
KCNH7

potassium voltage-gated channel, subfamily H (eag-related), member 7

chr11_+_60223281 0.425 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr1_-_160492982 0.425 NM_001184714
NM_001184715
NM_001184716
NM_052931
SLAMF6



SLAM family member 6



chr11_-_10715503 0.408 NM_001100163
NM_001206880
NM_001206881
NM_130385
MRVI1



murine retrovirus integration site 1 homolog



chr7_-_47579192 0.407 TNS3
tensin 3
chr3_+_158991035 0.401 NM_001197107
NM_001197108
NM_014575
SCHIP1


schwannomin interacting protein 1


chr2_-_100758970 0.401 NM_002285
AFF3
AF4/FMR2 family, member 3
chr12_-_54778456 0.400 NM_015481
ZNF385A
zinc finger protein 385A
chr3_-_114102488 0.393 NM_001164342
ZBTB20
zinc finger and BTB domain containing 20
chr1_-_45477016 0.388 NM_024602
HECTD3
HECT domain containing 3
chr16_+_72088507 0.385 NM_001126102
NM_005143
HP

haptoglobin

chr19_+_34663311 0.379 NM_001114093
NM_015578
LSM14A

LSM14A, SCD6 homolog A (S. cerevisiae)

chr19_-_16045669 0.374 NM_001128932
NM_021187
CYP4F11

cytochrome P450, family 4, subfamily F, polypeptide 11

chr5_-_58882274 0.367 NM_006203
PDE4D
phosphodiesterase 4D, cAMP-specific
chr6_-_3272349 0.364 SLC22A23
solute carrier family 22, member 23
chr6_-_32076997 0.352 NM_019105
TNXB
tenascin XB
chr8_+_62200524 0.346 NM_173519
CLVS1
clavesin 1
chr1_-_203320287 0.346 NM_002023
FMOD
fibromodulin
chr1_+_212475147 0.343 NM_001199756
PPP2R5A
protein phosphatase 2, regulatory subunit B', alpha
chr1_+_158323485 0.341 NM_001042583
NM_001042584
NM_001042585
NM_001042586
NM_001042587
NM_001185107
NM_001185108
NM_001185110
NM_001185112
NM_001185113
NM_001185114
NM_001185115
NM_030893
CD1E












CD1e molecule












chr15_+_65337707 0.340 NM_178859
OSTBETA
organic solute transporter beta
chr12_+_15699277 0.340 NM_030668
NM_030669
NM_030670
NM_030671
PTPRO



protein tyrosine phosphatase, receptor type, O



chr1_+_161632904 0.338 NM_001002273
NM_001002274
NM_001002275
NM_001190828
NM_004001
FCGR2B




FCGR2C
Fc fragment of IgG, low affinity IIb, receptor (CD32)




Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr11_-_16424391 0.334 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr2_+_1417232 0.329 NM_000547
NM_001206744
NM_001206745
NM_175719
TPO



thyroid peroxidase



chr5_-_148016576 0.325 NM_001040169
NM_001040172
NM_001040173
NM_199453
HTR4



5-hydroxytryptamine (serotonin) receptor 4



chr3_+_2933898 0.325 NM_001206956
NM_175613
CNTN4

contactin 4

chr16_-_71748697 0.322 NM_015020
PHLPP2
PH domain and leucine rich repeat protein phosphatase 2
chr2_+_1418179 0.316 NM_175721
NM_175722
TPO

thyroid peroxidase

chr12_+_53442732 0.316 NM_015319
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr2_-_192015751 0.316 STAT4
signal transducer and activator of transcription 4
chr3_+_97158453 0.314 NM_173655
EPHA6
EPH receptor A6
chr12_+_131438451 0.313 NM_198827
GPR133
G protein-coupled receptor 133
chr22_-_38881529 0.311 DDX17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chr2_+_102770401 0.308 NM_000877
IL1R1
interleukin 1 receptor, type I
chr15_+_40650411 0.307 NM_033510
DISP2
dispatched homolog 2 (Drosophila)
chr5_-_22212873 0.300 CDH12
cadherin 12, type 2 (N-cadherin 2)
chr11_-_19223516 0.298 NM_001127656
NM_003476
CSRP3

cysteine and glycine-rich protein 3 (cardiac LIM protein)

chr9_-_33395265 0.298 AQP7
aquaporin 7
chr1_-_203198772 0.296 NM_003465
CHIT1
chitinase 1 (chitotriosidase)
chr12_-_13256572 0.294 NM_001080554
NM_001080555
NM_001206842
GSG1


germ cell associated 1


chrX_-_117251302 0.293 NM_001168301
KLHL13
kelch-like 13 (Drosophila)
chr22_-_36019363 0.293 NM_203377
MB
myoglobin
chr17_+_65908038 0.290 BPTF
bromodomain PHD finger transcription factor
chr2_-_192015733 0.289 STAT4
signal transducer and activator of transcription 4
chr1_-_8003224 0.281 NM_001561
TNFRSF9
tumor necrosis factor receptor superfamily, member 9
chr12_-_113658826 0.278 NM_138451
IQCD
IQ motif containing D
chr7_-_115608366 0.278 NM_001244583
TFEC
transcription factor EC
chr13_-_36050758 0.277 NM_005584
MAB21L1
mab-21-like 1 (C. elegans)
chr7_-_115670811 0.273 TFEC
transcription factor EC
chr8_+_30496116 0.271 NM_001206847
LOC100507341
uncharacterized LOC100507341
chr13_-_36429798 0.270 NM_001195415
NM_001195416
NM_001195430
DCLK1


doublecortin-like kinase 1


chrM_+_11676 0.269


chr10_-_76868853 0.268 NM_001007271
NM_001007272
NM_001007273
DUSP13


dual specificity phosphatase 13


chr16_-_31160828 0.267 PRSS36
protease, serine, 36
chrX_+_111119278 0.267 NM_001195576
NM_001195578
LOC100329135

uncharacterized LOC100329135

chr10_+_24755440 0.264 KIAA1217
KIAA1217
chr1_-_232651227 0.264 NM_020808
SIPA1L2
signal-induced proliferation-associated 1 like 2
chrX_-_109561427 0.261 AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr10_+_18629613 0.260 NM_201590
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr12_-_16758312 0.257 NM_001243611
LMO3
LIM domain only 3 (rhombotin-like 2)
chr9_+_131445933 0.255 NM_001122821
SET
SET nuclear oncogene
chr14_+_75988765 0.255 NM_006399
BATF
basic leucine zipper transcription factor, ATF-like
chr5_-_150683326 0.255 NM_001145017
NM_181774
SLC36A3

solute carrier family 36 (proton/amino acid symporter), member 3

chr2_-_192016293 0.253 NM_001243835
STAT4
signal transducer and activator of transcription 4
chr11_+_62439120 0.249 NM_001085372
C11orf83
chromosome 11 open reading frame 83
chr2_-_89165652 0.247


chr1_-_156460390 0.247 MEF2D
myocyte enhancer factor 2D
chr5_-_176836488 0.246 F12
coagulation factor XII (Hageman factor)
chr4_+_15779887 0.244 NM_001775
CD38
CD38 molecule
chr2_-_192015934 0.244 NM_003151
STAT4
signal transducer and activator of transcription 4
chr8_-_7220489 0.243 NM_001164457
ZNF705G
zinc finger protein 705G
chr11_+_61976139 0.243 NM_002407
SCGB2A1
secretoglobin, family 2A, member 1
chr10_+_35484054 0.242 NM_182717
NM_182718
NM_182719
NM_182720
CREM



cAMP responsive element modulator



chr5_-_37835592 0.241 NM_199231
GDNF
glial cell derived neurotrophic factor
chr1_+_174417211 0.241 NM_005684
GPR52
G protein-coupled receptor 52

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.