Motif ID: NFE2L1.p2

Z-value: 1.203


Transcription factors associated with NFE2L1.p2:

Gene SymbolEntrez IDGene Name
NFE2L1 4779 nuclear factor (erythroid-derived 2)-like 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NFE2L1hg19_v1_chr17_+_46126134_461261480.056.9e-01Click!


Activity profile for motif NFE2L1.p2.

activity profile for motif NFE2L1.p2


Sorted Z-values histogram for motif NFE2L1.p2

Sorted Z-values for motif NFE2L1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFE2L1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_5566923 10.074 NM_005185
CALML3
calmodulin-like 3
chr19_-_36019194 9.483 NM_001166034
NM_001166035
NM_198538
SBSN


suprabasin


chr12_-_123187842 7.751 NM_177551
HCAR2
hydroxycarboxylic acid receptor 2
chr1_+_212738675 7.466 NM_001030287
ATF3
activating transcription factor 3
chr10_-_92680784 6.628 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr17_-_39216343 6.350 NM_001165252
LOC730755
keratin associated protein 2-4-like
chr6_+_154897419 6.148


chr10_-_92681025 5.610 NM_014391
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr12_-_123201319 5.096 NM_006018
HCAR3
hydroxycarboxylic acid receptor 3
chr17_-_39222126 5.094 NM_033184
KRTAP2-4
keratin associated protein 2-4
chr18_+_28898051 4.904 NM_001942
DSG1
desmoglein 1
chr5_+_147582338 4.805 NM_001195290
NM_205841
SPINK6

serine peptidase inhibitor, Kazal type 6

chr13_+_52034639 4.686


chr16_+_69139466 4.587 NM_001199280
HAS3
hyaluronan synthase 3
chr1_+_212781969 4.134 NM_001040619
NM_001206484
NM_001206488
NM_001674
ATF3



activating transcription factor 3



chr17_-_39211462 3.741 NM_033032
KRTAP2-2
keratin associated protein 2-2
chr12_+_18891040 3.583 NM_033328
CAPZA3
capping protein (actin filament) muscle Z-line, alpha 3
chr19_+_15160194 3.570 NM_012114
CASP14
caspase 14, apoptosis-related cysteine peptidase
chr6_-_56716412 3.523 DST
dystonin
chr9_+_102584136 3.495 NM_006981
NM_173199
NM_173200
NR4A3


nuclear receptor subfamily 4, group A, member 3


chr1_+_207070787 3.475 NM_001185156
NM_001185157
NM_001185158
NM_006850
IL24



interleukin 24



chr5_+_145317297 3.369 SH3RF2
SH3 domain containing ring finger 2
chr11_-_85430117 3.352 NM_206929
SYTL2
synaptotagmin-like 2
chr4_+_74606222 3.343 NM_000584
IL8
interleukin 8
chr21_-_31588242 3.254 NM_199328
CLDN8
claudin 8
chr3_-_143567163 3.135 NM_173653
SLC9A9
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr5_+_59784004 3.124 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr11_-_16424391 3.103 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr15_-_80263460 3.049 NM_001114735
NM_004049
BCL2A1

BCL2-related protein A1

chr2_+_113735595 3.017 NM_019618
IL36G
interleukin 36, gamma
chr2_-_70189396 2.938 NM_152792
ASPRV1
aspartic peptidase, retroviral-like 1
chr8_-_20112691 2.911 NM_021020
LZTS1
leucine zipper, putative tumor suppressor 1
chr2_-_96781887 2.909 NM_000682
ADRA2B
adrenergic, alpha-2B-, receptor
chr2_+_171034654 2.786 NM_001083615
NM_001171642
NM_138995
MYO3B


myosin IIIB


chr1_+_212782103 2.740 ATF3
activating transcription factor 3
chr17_+_38119225 2.723 NM_178171
GSDMA
gasdermin A
chr1_-_203154304 2.697 CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chr20_-_23030141 2.644 NM_000361
THBD
thrombomodulin
chr10_-_64576074 2.605 EGR2
early growth response 2
chr1_-_59248287 2.584 JUN
jun proto-oncogene
chr10_-_64576123 2.567 NM_000399
NM_001136177
NM_001136179
EGR2


early growth response 2


chr10_-_98031154 2.527 NM_001114094
NM_013314
BLNK

B-cell linker

chr18_-_45663667 2.510 NM_001039360
ZBTB7C
zinc finger and BTB domain containing 7C
chrX_+_152770083 2.381 BGN
biglycan
chr6_+_152128685 2.375 NM_000125
ESR1
estrogen receptor 1
chr19_+_13263890 2.374 IER2
immediate early response 2
chr11_-_6790187 2.315 NM_001004490
OR2AG2
olfactory receptor, family 2, subfamily AG, member 2
chr2_-_106015423 2.306 NM_001039492
NM_001450
NM_201555
FHL2


four and a half LIM domains 2


chr16_+_82660390 2.281 NM_001220488
NM_001220489
NM_001220490
NM_001220491
NM_001220492
NM_001257
CDH13





cadherin 13, H-cadherin (heart)





chr8_-_82395401 2.277 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr1_+_45266048 2.273 PLK3
polo-like kinase 3
chr8_+_75736771 2.262 NM_015886
PI15
peptidase inhibitor 15
chr10_-_23633771 2.261 NM_153714
C10orf67
chromosome 10 open reading frame 67
chr11_-_7961066 2.221 NM_001003745
OR10A3
olfactory receptor, family 10, subfamily A, member 3
chr17_+_70117154 2.188 NM_000346
SOX9
SRY (sex determining region Y)-box 9
chr11_-_123848397 2.187 NM_001004474
OR10S1
olfactory receptor, family 10, subfamily S, member 1
chr22_+_38597938 2.183 NM_001161572
NM_001161574
NM_012323
MAFF


v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)


chr5_+_53751430 2.146 NM_006308
HSPB3
heat shock 27kDa protein 3
chr11_-_5537815 2.146 NM_145053
UBQLNL
ubiquilin-like
chrX_+_105969875 2.143 NM_194463
RNF128
ring finger protein 128
chr17_+_70117168 2.132 SOX9
SRY (sex determining region Y)-box 9
chr11_-_85430382 2.114 NM_001162952
NM_206930
SYTL2

synaptotagmin-like 2

chr12_-_45307710 2.096 NM_001145110
NELL2
NEL-like 2 (chicken)
chr3_-_48601200 2.085 NM_033199
UCN2
urocortin 2
chr16_+_82660573 2.058 CDH13
cadherin 13, H-cadherin (heart)
chr1_-_152061529 2.029 NM_001008536
TCHHL1
trichohyalin-like 1
chr22_+_38598065 2.002 MAFF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr17_+_70117177 1.996 SOX9
SRY (sex determining region Y)-box 9
chr1_-_200377262 1.983 ZNF281
zinc finger protein 281
chr9_+_17578952 1.978 NM_003026
SH3GL2
SH3-domain GRB2-like 2
chr4_-_186578122 1.971 NM_001145674
NM_001145675
SORBS2

sorbin and SH3 domain containing 2

chr10_+_90484300 1.963 NM_001080518
LIPK
lipase, family member K
chr3_-_108672547 1.963 NM_005459
GUCA1C
guanylate cyclase activator 1C
chr17_+_17398334 1.961


chr16_-_4562979 1.955 C16orf5
chromosome 16 open reading frame 5
chr5_-_112770537 1.952 NM_032028
TSSK1B
testis-specific serine kinase 1B
chr1_-_29309092 1.942


chr3_+_121774208 1.942 NM_001206924
NM_001206925
NM_175862
CD86


CD86 molecule


chrX_-_154563735 1.925 NM_001289
CLIC2
chloride intracellular channel 2
chr1_+_212788359 1.923 NM_001206486
ATF3
activating transcription factor 3
chr2_-_172967234 1.900 NM_004405
DLX2
distal-less homeobox 2
chr1_-_186649421 1.889 NM_000963
PTGS2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
chr6_+_29624757 1.858 NM_001008228
NM_001008229
NM_001170418
NM_002433
NM_206809
NM_206810
NM_206811
NM_206812
NM_206814
MOG








myelin oligodendrocyte glycoprotein








chr5_+_148206155 1.851 NM_000024
ADRB2
adrenergic, beta-2-, receptor, surface
chr1_+_152956563 1.812 NM_001199828
NM_005987
SPRR1A

small proline-rich protein 1A

chr14_+_21467413 1.809 NM_014579
SLC39A2
solute carrier family 39 (zinc transporter), member 2
chr6_-_30712294 1.771 NM_003897
IER3
immediate early response 3
chr9_-_34662629 1.760 NM_006664
CCL27
chemokine (C-C motif) ligand 27
chr7_-_14025826 1.751 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr2_-_172967014 1.746 DLX2
distal-less homeobox 2
chr12_-_89746244 1.744 NM_001946
NM_022652
DUSP6

dual specificity phosphatase 6

chr5_+_147443534 1.741 NM_001127698
NM_001127699
NM_006846
SPINK5


serine peptidase inhibitor, Kazal type 5


chr1_-_200377488 1.719 ZNF281
zinc finger protein 281
chr3_-_8693723 1.692 NM_015931
C3orf32
chromosome 3 open reading frame 32
chr2_-_46384 1.692 NM_001077710
FAM110C
family with sequence similarity 110, member C
chr3_-_193272587 1.685 NM_032279
ATP13A4
ATPase type 13A4
chr1_+_153330329 1.675 NM_002965
S100A9
S100 calcium binding protein A9
chr12_-_123380682 1.656 NM_024667
VPS37B
vacuolar protein sorting 37 homolog B (S. cerevisiae)
chr4_-_186577858 1.650 SORBS2
sorbin and SH3 domain containing 2
chr20_+_51588945 1.649 NM_173485
TSHZ2
teashirt zinc finger homeobox 2
chr17_-_39768939 1.647 NM_005557
KRT16
keratin 16
chr1_+_209941894 1.645 TRAF3IP3
TRAF3 interacting protein 3
chr8_-_22550708 1.633 NM_004430
EGR3
early growth response 3
chr2_-_172967627 1.615 DLX2
distal-less homeobox 2
chr3_-_99594915 1.615 NM_014890
FILIP1L
filamin A interacting protein 1-like
chr10_-_90611675 1.602 NM_144590
ANKRD22
ankyrin repeat domain 22
chr7_+_1126442 1.587 NM_001039966
NM_001505
GPER

G protein-coupled estrogen receptor 1

chr1_-_173020011 1.584 NM_005092
TNFSF18
tumor necrosis factor (ligand) superfamily, member 18
chr1_+_207039153 1.570 NM_018724
IL20
interleukin 20
chr11_+_124120422 1.562 NM_001002905
OR8G1
olfactory receptor, family 8, subfamily G, member 1
chrX_-_10535476 1.561 NM_001193278
NM_001193279
NM_001193280
NM_001193281
MID1



midline 1 (Opitz/BBB syndrome)



chr17_-_39203423 1.558 NM_001123387
KRTAP2-1
keratin associated protein 2-1
chr5_-_95748688 1.556 NM_001177876
PCSK1
proprotein convertase subtilisin/kexin type 1
chr11_+_117947726 1.546 NM_001083947
NM_001173551
NM_001173552
NM_019894
TMPRSS4



transmembrane protease, serine 4



chr1_+_161676761 1.534 NM_001184866
NM_001184867
NM_001184870
NM_001184871
NM_001184872
NM_001184873
NM_032738
FCRLA






Fc receptor-like A






chr10_+_5488521 1.529 NM_005863
NET1
neuroepithelial cell transforming 1
chr16_+_86544233 1.525 FOXF1
forkhead box F1
chr18_-_56296188 1.509 NM_052947
ALPK2
alpha-kinase 2
chr11_+_76813884 1.499 NM_006189
OMP
olfactory marker protein
chr11_-_57335080 1.487 NM_004223
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr12_-_89746238 1.487 DUSP6
dual specificity phosphatase 6
chr11_+_117947785 1.484 TMPRSS4
transmembrane protease, serine 4
chr1_-_146696896 1.476 FMO5
flavin containing monooxygenase 5
chr12_-_89745997 1.470 DUSP6
dual specificity phosphatase 6
chr7_+_129932973 1.462 NM_001163446
NM_016352
CPA4

carboxypeptidase A4

chr11_-_6817013 1.454 NM_003696
OR6A2
olfactory receptor, family 6, subfamily A, member 2
chr1_+_100111430 1.452 NM_017734
PALMD
palmdelphin
chr22_+_38201300 1.436 H1F0
H1 histone family, member 0
chr3_-_108248168 1.435 NM_014981
MYH15
myosin, heavy chain 15
chr7_+_29234325 1.419 CHN2
chimerin (chimaerin) 2
chr16_+_82660641 1.418 CDH13
cadherin 13, H-cadherin (heart)
chr11_-_26593667 1.394 NM_001135091
NM_001135092
NM_145650
MUC15


mucin 15, cell surface associated


chr2_-_161056573 1.388 NM_000888
ITGB6
integrin, beta 6
chrX_+_150345055 1.383 NM_004224
GPR50
G protein-coupled receptor 50
chr20_+_54823787 1.376 NM_019888
MC3R
melanocortin 3 receptor
chrX_+_70443055 1.376 NM_000166
GJB1
gap junction protein, beta 1, 32kDa
chr2_-_165811995 1.372 NM_001199148
NM_173512
SLC38A11

solute carrier family 38, member 11

chr22_-_33402648 1.368 NM_003490
NM_133633
SYN3

synapsin III

chr19_+_42259397 1.366 NM_002483
CEACAM6
carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
chr5_+_140613937 1.354 PCDHB18
protocadherin beta 18 pseudogene
chr7_+_107110501 1.350 NM_005295
GPR22
G protein-coupled receptor 22
chr19_-_7968426 1.341


chr5_+_36608430 1.340 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr17_-_3461288 1.332 NM_145068
TRPV3
transient receptor potential cation channel, subfamily V, member 3
chr7_-_82791799 1.331 PCLO
piccolo (presynaptic cytomatrix protein)
chr7_-_82792127 1.330 NM_014510
NM_033026
PCLO

piccolo (presynaptic cytomatrix protein)

chr1_+_45265896 1.330 PLK3
polo-like kinase 3
chr4_+_3465032 1.321 NM_001164673
NM_173660
DOK7

docking protein 7

chr17_-_46671043 1.289 NM_002147
HOXB5
homeobox B5
chr16_-_4588738 1.287 NM_001199055
NM_001199056
NM_013399
C16orf5


chromosome 16 open reading frame 5


chr7_+_80275967 1.284 CD36
CD36 molecule (thrombospondin receptor)
chr1_+_164528914 1.270 PBX1
pre-B-cell leukemia homeobox 1
chr1_-_154178783 1.265 NM_001010979
C1orf189
chromosome 1 open reading frame 189
chr12_+_109577201 1.264 NM_001093
ACACB
acetyl-CoA carboxylase beta
chr12_-_8815370 1.258 NM_003480
MFAP5
microfibrillar associated protein 5
chr22_+_38201232 1.248 H1F0
H1 histone family, member 0
chr6_+_55039070 1.248 NM_001526
HCRTR2
hypocretin (orexin) receptor 2
chr3_-_45267068 1.245 TMEM158
transmembrane protein 158 (gene/pseudogene)
chr17_-_39675078 1.230 NM_002275
KRT15
keratin 15
chr19_-_51512803 1.227 NM_012315
KLK9
kallikrein-related peptidase 9
chr12_-_123380608 1.226


chr12_-_48119224 1.226 NM_001172439
NM_001172440
NM_006025
ENDOU


endonuclease, polyU-specific


chr12_-_123380628 1.214 VPS37B
vacuolar protein sorting 37 homolog B (S. cerevisiae)
chrX_-_110513750 1.206 NM_014289
CAPN6
calpain 6
chr4_-_23891608 1.202 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr17_-_42081836 1.201 NM_004160
PYY
peptide YY
chr6_-_166401526 1.197 LINC00473
long intergenic non-protein coding RNA 473
chr12_-_57634474 1.195 NM_020142
NDUFA4L2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
chr20_+_327329 1.194 NM_024958
NRSN2
neurensin 2
chr6_+_72922513 1.191 NM_001168407
NM_001168408
RIMS1

regulating synaptic membrane exocytosis 1

chr4_-_105412466 1.190 NM_025212
CXXC4
CXXC finger protein 4
chr5_-_11903964 1.183 NM_001332
CTNND2
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
chr3_+_53529030 1.180 NM_000720
NM_001128839
NM_001128840
CACNA1D


calcium channel, voltage-dependent, L type, alpha 1D subunit


chr17_+_57915192 1.175


chr17_+_4802866 1.175 NM_001145536
C17orf107
chromosome 17 open reading frame 107
chr15_-_74726258 1.172 NM_001146029
NM_003612
SEMA7A

semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)

chr10_-_5541401 1.171 NM_017422
CALML5
calmodulin-like 5
chr12_-_10324675 1.171 NM_001172632
NM_001172633
NM_002543
OLR1


oxidized low density lipoprotein (lectin-like) receptor 1


chr2_-_231789940 1.169 NM_005683
GPR55
G protein-coupled receptor 55
chr11_-_88781039 1.165 NM_001143831
GRM5
glutamate receptor, metabotropic 5
chr14_+_23511375 1.162 NM_001099780
PSMB11
proteasome (prosome, macropain) subunit, beta type, 11
chr4_+_75230856 1.160 NM_001432
EREG
epiregulin
chr5_+_140579182 1.154 NM_018931
PCDHB11
protocadherin beta 11
chr12_+_54332575 1.153 NM_017410
HOXC13
homeobox C13
chr19_-_9325546 1.139 NM_001005191
OR7D4
olfactory receptor, family 7, subfamily D, member 4
chr5_-_150948504 1.133 NM_001447
FAT2
FAT tumor suppressor homolog 2 (Drosophila)
chr19_-_51522953 1.130 NM_145888
KLK10
kallikrein-related peptidase 10
chr11_+_66188474 1.128 NM_178864
NPAS4
neuronal PAS domain protein 4
chr7_+_39017608 1.128 NM_001166018
NM_007252
POU6F2

POU class 6 homeobox 2

chr12_-_8815266 1.127 MFAP5
microfibrillar associated protein 5
chr6_-_11779279 1.121 NM_001143948
NM_032744
C6orf105

chromosome 6 open reading frame 105

chr16_+_30759619 1.119 NM_000294
NM_001172432
PHKG2

phosphorylase kinase, gamma 2 (testis)

chr4_+_184827882 1.118


chr19_-_10047014 1.114 NM_058164
OLFM2
olfactomedin 2
chr11_+_6806247 1.112 NM_001004489
OR2AG1
olfactory receptor, family 2, subfamily AG, member 1
chr14_-_94423766 1.110 NM_016150
ASB2
ankyrin repeat and SOCS box containing 2
chr22_+_38201113 1.101 NM_005318
H1F0
H1 histone family, member 0
chr11_+_124134699 1.100 NM_001005198
OR8G5
olfactory receptor, family 8, subfamily G, member 5
chr2_-_136873740 1.095 NM_001008540
CXCR4
chemokine (C-X-C motif) receptor 4
chr13_-_36429798 1.087 NM_001195415
NM_001195416
NM_001195430
DCLK1


doublecortin-like kinase 1



Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.61 1.07e-03 GO:0032501 multicellular organismal process
5.66 3.82e-03 GO:0008544 epidermis development
4.93 1.41e-02 GO:0032101 regulation of response to external stimulus
3.03 1.59e-02 GO:0045595 regulation of cell differentiation
2.85 2.28e-02 GO:0007267 cell-cell signaling

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.68 4.25e-04 GO:0071944 cell periphery
2.02 9.17e-04 GO:0044459 plasma membrane part
1.65 1.16e-03 GO:0005886 plasma membrane

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
10.65 3.83e-03 GO:0042562 hormone binding
2.11 4.43e-03 GO:0004872 receptor activity
2.31 5.25e-03 GO:0004888 transmembrane receptor activity
2.63 9.70e-03 GO:0004930 G-protein coupled receptor activity
1.93 1.00e-02 GO:0004871 signal transducer activity
1.93 1.00e-02 GO:0060089 molecular transducer activity