Motif ID: NFE2.p2

Z-value: 0.945


Transcription factors associated with NFE2.p2:

Gene SymbolEntrez IDGene Name
NFE2 4778 nuclear factor (erythroid-derived 2), 45kDa

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NFE2hg19_v1_chr12_-_54694647_54694667-0.631.7e-09Click!


Activity profile for motif NFE2.p2.

activity profile for motif NFE2.p2


Sorted Z-values histogram for motif NFE2.p2

Sorted Z-values for motif NFE2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFE2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_+_82068830 15.156 NM_002153
HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr7_+_73245192 11.502 NM_001305
CLDN4
claudin 4
chr16_+_82068958 11.033 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr4_-_39033981 9.823 NM_024943
TMEM156
transmembrane protein 156
chr12_-_91573264 9.766 NM_133503
DCN
decorin
chr4_-_76944585 9.472 NM_001565
CXCL10
chemokine (C-X-C motif) ligand 10
chr16_+_82068910 9.069 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr6_-_24877453 8.429 NM_015864
FAM65B
family with sequence similarity 65, member B
chr18_+_55888838 7.445 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr3_-_196065191 7.223 TM4SF19
transmembrane 4 L six family member 19
chr18_+_55888799 7.122 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr17_-_39661803 6.938 NM_002274
NM_153490
KRT13

keratin 13

chr18_+_55888750 6.729 NM_001144966
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr18_+_61554938 6.573 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr3_-_196065243 6.051 NM_001204897
NM_001204898
NM_138461
TM4SF19


transmembrane 4 L six family member 19


chr15_-_74494851 5.790 STRA6
stimulated by retinoic acid gene 6 homolog (mouse)
chrX_-_15511710 5.598 NM_001018109
NM_003662
PIR

pirin (iron-binding nuclear protein)

chr15_-_74494780 5.577 STRA6
stimulated by retinoic acid gene 6 homolog (mouse)
chr16_-_69760444 5.331 NM_000903
NM_001025433
NM_001025434
NQO1


NAD(P)H dehydrogenase, quinone 1


chr5_+_159626047 5.231 NM_001040442
FABP6
fatty acid binding protein 6, ileal
chr16_+_83986826 5.163 NM_182981
OSGIN1
oxidative stress induced growth inhibitor 1
chr19_-_46285645 5.122 DMPK
dystrophia myotonica-protein kinase
chr6_-_24645955 5.048 NM_001168375
NM_001168376
NM_001168374
NM_001168377
NM_014809
KIAA0319




KIAA0319




chr17_+_18625335 4.997 NM_001037330
TRIM16L
tripartite motif containing 16-like
chr15_-_76304762 4.989 NM_138573
NRG4
neuregulin 4
chr1_+_223889253 4.904 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chr19_-_6670598 4.748 NM_003807
NM_172014
TNFSF14

tumor necrosis factor (ligand) superfamily, member 14

chrX_-_110513750 4.635 NM_014289
CAPN6
calpain 6
chrX_-_110513665 4.618 CAPN6
calpain 6
chr16_-_30124829 4.525 NM_024307
GDPD3
glycerophosphodiester phosphodiesterase domain containing 3
chr11_+_10477480 4.489 NM_001025390
AMPD3
adenosine monophosphate deaminase 3
chr1_-_153029987 4.478 NM_005988
SPRR2A
small proline-rich protein 2A
chr10_+_123872440 4.418 TACC2
transforming, acidic coiled-coil containing protein 2
chr1_-_45272956 4.266 NM_001013632
TCTEX1D4
Tctex1 domain containing 4
chrX_-_15511358 4.225 PIR
pirin (iron-binding nuclear protein)
chr12_-_53343607 4.221 KRT8
keratin 8
chr20_+_43343523 4.202 WISP2
WNT1 inducible signaling pathway protein 2
chr17_-_79881304 4.145 NM_032711
MAFG
v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)
chr17_-_45899133 4.105 NM_145798
OSBPL7
oxysterol binding protein-like 7
chr5_+_159656436 4.102 NM_001445
FABP6
fatty acid binding protein 6, ileal
chr12_+_101988746 3.991 NM_002465
NM_206819
NM_206820
NM_206821
MYBPC1



myosin binding protein C, slow type



chr14_-_24732344 3.982 NM_000359
TGM1
transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase)
chr6_+_31895401 3.835 C2
complement component 2
chr17_-_202617 3.831 NM_001190411
NM_001190412
NM_001190413
NM_006987
RPH3AL



rabphilin 3A-like (without C2 domains)



chr12_-_53298765 3.807 NM_002273
KRT8
keratin 8
chr12_+_56075418 3.710 METTL7B
methyltransferase like 7B
chr10_+_88780045 3.708 NM_001146157
FAM25A
family with sequence similarity 25, member A
chr17_-_202557 3.669 RPH3AL
rabphilin 3A-like (without C2 domains)
chr14_-_65409445 3.541 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr17_-_45899118 3.523 OSBPL7
oxysterol binding protein-like 7
chr16_+_15596122 3.455 NM_001142469
C16orf45
chromosome 16 open reading frame 45
chr15_+_74495341 3.435


chr9_+_140172273 3.280 NM_017723
C9orf167
chromosome 9 open reading frame 167
chr19_+_40872709 3.214 PLD3
phospholipase D family, member 3
chr12_+_56075329 3.204 NM_152637
METTL7B
methyltransferase like 7B
chr20_+_6748744 3.191 NM_001200
BMP2
bone morphogenetic protein 2
chr9_-_130341265 2.984 NM_001035534
FAM129B
family with sequence similarity 129, member B
chr6_+_1611544 2.977 FOXC1
forkhead box C1
chr17_+_25799024 2.918 NM_014238
KSR1
kinase suppressor of ras 1
chr16_+_89988416 2.871 NM_001197181
TUBB3
tubulin, beta 3 class III
chr5_-_42811959 2.826 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr15_+_89182038 2.807 NM_002201
ISG20
interferon stimulated exonuclease gene 20kDa
chr16_+_67312057 2.750 NM_001129727
PLEKHG4
pleckstrin homology domain containing, family G (with RhoGef domain) member 4
chr19_-_49243836 2.745 NM_017805
RASIP1
Ras interacting protein 1
chr19_-_46285752 2.719 NM_001081560
NM_001081562
NM_004409
DMPK


dystrophia myotonica-protein kinase


chr4_-_122085475 2.701 NM_024873
TNIP3
TNFAIP3 interacting protein 3
chr16_+_4430878 2.701 VASN
vasorin
chr6_-_84140744 2.698 ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr4_-_139163222 2.676 NM_014331
SLC7A11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr20_-_633844 2.672 NM_080725
SRXN1
sulfiredoxin 1
chr19_-_46285746 2.659 DMPK
dystrophia myotonica-protein kinase
chr14_-_95942037 2.644 NM_152592
C14orf49
chromosome 14 open reading frame 49
chrX_-_15402469 2.620 NM_004469
FIGF
c-fos induced growth factor (vascular endothelial growth factor D)
chr17_-_34207308 2.616 NM_002985
CCL5
chemokine (C-C motif) ligand 5
chr6_-_84140651 2.597 ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr9_+_140119643 2.589 NM_199001
C9orf169
chromosome 9 open reading frame 169
chr6_-_84140758 2.586 ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr3_-_149095413 2.573 TM4SF1
transmembrane 4 L six family member 1
chr11_+_1855673 2.568 NM_138567
SYT8
synaptotagmin VIII
chr7_+_28448970 2.543 LOC401317
uncharacterized LOC401317
chr3_-_149095333 2.536 TM4SF1
transmembrane 4 L six family member 1
chr2_-_190927321 2.532 NM_005259
MSTN
myostatin
chr22_-_30642683 2.530 NM_002309
LIF
leukemia inhibitory factor (cholinergic differentiation factor)
chr11_+_10476665 2.507 NM_001025389
AMPD3
adenosine monophosphate deaminase 3
chr2_+_169926084 2.491 DHRS9
dehydrogenase/reductase (SDR family) member 9
chr10_-_71892514 2.480 AIFM2
apoptosis-inducing factor, mitochondrion-associated, 2
chr3_+_141087298 2.468 ZBTB38
zinc finger and BTB domain containing 38
chr19_+_38794800 2.463 NM_033520
C19orf33
chromosome 19 open reading frame 33
chrX_+_9431314 2.453 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr3_+_160394946 2.443 NM_025047
ARL14
ADP-ribosylation factor-like 14
chr9_+_35538890 2.409 RUSC2
RUN and SH3 domain containing 2
chr6_-_84140854 2.400 NM_002395
ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr5_+_179247903 2.397 SQSTM1
sequestosome 1
chr17_-_39216343 2.384 NM_001165252
LOC730755
keratin associated protein 2-4-like
chr2_+_172950207 2.373 NM_001038493
NM_178120
DLX1

distal-less homeobox 1

chr19_-_44285012 2.373 KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr3_-_149095458 2.364 TM4SF1
transmembrane 4 L six family member 1
chr5_+_148520985 2.358 NM_014945
ABLIM3
actin binding LIM protein family, member 3
chr5_+_179247841 2.330 NM_003900
SQSTM1
sequestosome 1
chr3_+_141043054 2.307 NM_001080412
ZBTB38
zinc finger and BTB domain containing 38
chr8_-_12973752 2.284 NM_001164271
DLC1
deleted in liver cancer 1
chr17_-_76921205 2.278 TIMP2
TIMP metallopeptidase inhibitor 2
chr5_+_42756919 2.272 NM_001134848
CCDC152
coiled-coil domain containing 152
chr16_-_28620648 2.234 NM_177530
NM_177534
SULT1A1

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

chr10_-_71892596 2.232 NM_001198696
NM_032797
AIFM2

apoptosis-inducing factor, mitochondrion-associated, 2

chr16_-_28607694 2.223 NM_177528
SULT1A2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr21_-_35986744 2.215 NM_203417
RCAN1
regulator of calcineurin 1
chr5_+_179247911 2.197 SQSTM1
sequestosome 1
chr4_+_74606222 2.159 NM_000584
IL8
interleukin 8
chr9_+_71819926 2.156 NM_001170415
NM_001170416
TJP2

tight junction protein 2 (zona occludens 2)

chr11_+_128563993 2.139 FLI1
Friend leukemia virus integration 1
chr1_-_45987548 2.122 NM_002574
NM_181696
NM_181697
PRDX1


peroxiredoxin 1


chr7_-_93519990 2.117 NM_006528
TFPI2
tissue factor pathway inhibitor 2
chr19_-_6670078 2.110 TNFSF14
tumor necrosis factor (ligand) superfamily, member 14
chr19_+_38880839 2.096 NM_001039616
NM_001042522
SPRED3

sprouty-related, EVH1 domain containing 3

chr1_+_241695433 2.092 NM_003679
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr19_-_4559713 2.086 NM_032108
SEMA6B
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
chr3_-_87040246 2.082 NM_016206
VGLL3
vestigial like 3 (Drosophila)
chr15_+_40531236 2.080 PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr11_+_62475113 2.074 NM_012202
GNG3
guanine nucleotide binding protein (G protein), gamma 3
chr11_+_2924504 2.065 SLC22A18
solute carrier family 22, member 18
chr11_-_65667809 2.034 FOSL1
FOS-like antigen 1
chr19_+_38865184 2.014 NM_002812
PSMD8
proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
chr2_+_234637772 1.990 NM_019093
UGT1A3
UDP glucuronosyltransferase 1 family, polypeptide A3
chr22_+_21369441 1.973 NM_001159554
NM_005446
P2RX6

purinergic receptor P2X, ligand-gated ion channel, 6

chr14_+_105147442 1.969


chr18_+_61637262 1.952 NM_001031848
NM_002640
NM_198833
SERPINB8


serpin peptidase inhibitor, clade B (ovalbumin), member 8


chr1_-_153013593 1.948 NM_006945
SPRR2D
small proline-rich protein 2D
chrX_-_15683153 1.944 NM_020665
TMEM27
transmembrane protein 27
chr7_+_90339146 1.942 CDK14
cyclin-dependent kinase 14
chr9_-_99064385 1.937 NM_000197
HSD17B3
hydroxysteroid (17-beta) dehydrogenase 3
chrX_+_99899162 1.937 NM_014467
SRPX2
sushi-repeat containing protein, X-linked 2
chr20_-_34195409 1.925 FER1L4
fer-1-like 4 (C. elegans) pseudogene
chr17_-_76921453 1.923 NM_003255
TIMP2
TIMP metallopeptidase inhibitor 2
chr11_-_67141647 1.914 NM_001166212
CLCF1
cardiotrophin-like cytokine factor 1
chr5_+_176875325 1.907 NM_001174102
PRR7
proline rich 7 (synaptic)
chr1_-_94374949 1.891 GCLM
glutamate-cysteine ligase, modifier subunit
chr6_-_31745048 1.883 NM_025258
C6orf27
chromosome 6 open reading frame 27
chr1_-_109849613 1.869 NM_001010985
MYBPHL
myosin binding protein H-like
chr6_-_35696359 1.867 NM_001145775
FKBP5
FK506 binding protein 5
chr2_+_202122753 1.864 NM_001080125
CASP8
caspase 8, apoptosis-related cysteine peptidase
chr11_-_65667860 1.858 NM_005438
FOSL1
FOS-like antigen 1
chr2_+_11680079 1.851 NM_148903
GREB1
growth regulation by estrogen in breast cancer 1
chr12_-_106533810 1.847 NM_014840
NUAK1
NUAK family, SNF1-like kinase, 1
chr6_-_159239254 1.843 EZR
ezrin
chr16_+_67311412 1.840 NM_015432
PLEKHG4
pleckstrin homology domain containing, family G (with RhoGef domain) member 4
chr19_-_44285407 1.835 NM_002250
KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr1_+_81771844 1.818 LPHN2
latrophilin 2
chr6_-_159239269 1.815 NM_003379
EZR
ezrin
chr6_-_159239198 1.810 EZR
ezrin
chr11_-_65667858 1.807 FOSL1
FOS-like antigen 1
chrX_+_99899388 1.790 SRPX2
sushi-repeat containing protein, X-linked 2
chr12_-_15815073 1.777 EPS8
epidermal growth factor receptor pathway substrate 8
chr8_-_143808369 1.775 LOC100288181
uncharacterized LOC100288181
chr20_-_1309782 1.775 SDCBP2
syndecan binding protein (syntenin) 2
chr3_-_186262114 1.763 NM_017541
CRYGS
crystallin, gamma S
chr1_+_110546569 1.751 NM_001242675
NM_001242676
AHCYL1

adenosylhomocysteinase-like 1

chr1_-_94374986 1.746 NM_002061
GCLM
glutamate-cysteine ligase, modifier subunit
chr16_-_28608367 1.740 NM_001054
SULT1A2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr7_+_1577118 1.738 MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr16_+_67001377 1.737 NM_001185176
CES3
carboxylesterase 3
chr2_+_27505296 1.732 NM_032546
NM_187841
TRIM54

tripartite motif containing 54

chr12_-_56236614 1.704 NM_002429
MMP19
matrix metallopeptidase 19
chr9_+_131902208 1.689 PPP2R4
protein phosphatase 2A activator, regulatory subunit 4
chr11_+_19372270 1.680 NM_001111018
NAV2
neuron navigator 2
chr20_-_1309809 1.674 NM_080489
SDCBP2
syndecan binding protein (syntenin) 2
chr4_-_987163 1.672 NM_022042
NM_134425
NM_213613
SLC26A1


solute carrier family 26 (sulfate transporter), member 1


chr9_-_100935173 1.662 NM_003389
CORO2A
coronin, actin binding protein, 2A
chr16_+_71929399 1.662 IST1
increased sodium tolerance 1 homolog (yeast)
chr6_-_33548017 1.657 NM_001188
BAK1
BCL2-antagonist/killer 1
chr9_-_113018711 1.655 TXN
thioredoxin
chr6_-_33547833 1.653 BAK1
BCL2-antagonist/killer 1
chr11_-_117800067 1.650 NM_001077263
NM_001206789
NM_001206790
NM_001244995
TMPRSS13



transmembrane protease, serine 13



chr19_-_39235113 1.650 NM_144691
CAPN12
calpain 12
chr12_-_51403028 1.640 NM_001174130
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr2_+_28615695 1.638 FOSL2
FOS-like antigen 2
chrX_-_53310748 1.614 NM_001243197
NM_015075
IQSEC2

IQ motif and Sec7 domain 2

chr4_-_159093523 1.607 FAM198B
family with sequence similarity 198, member B
chr2_-_85641128 1.601 CAPG
capping protein (actin filament), gelsolin-like
chr3_-_149095517 1.601 NM_014220
TM4SF1
transmembrane 4 L six family member 1
chr16_+_53133063 1.597 CHD9
chromodomain helicase DNA binding protein 9
chr6_+_64231626 1.591 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr15_-_74495093 1.579 NM_001199042
NM_022369
STRA6

stimulated by retinoic acid gene 6 homolog (mouse)

chr16_-_28621279 1.575 NM_001055
NM_177529
SULT1A1

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

chr17_+_9745847 1.574 GLP2R
glucagon-like peptide 2 receptor
chr12_+_56546203 1.573 NM_001199629
NM_002475
MYL6B

myosin, light chain 6B, alkali, smooth muscle and non-muscle

chr1_+_26348265 1.566 NM_004455
EXTL1
exostoses (multiple)-like 1
chr22_-_32058166 1.557 PISD
phosphatidylserine decarboxylase
chr15_+_40532034 1.554 NM_020168
PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr15_+_86220267 1.537 NM_144767
AKAP13
A kinase (PRKA) anchor protein 13
chr9_-_139922595 1.534 ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr2_+_28615771 1.534 NM_005253
FOSL2
FOS-like antigen 2
chr12_+_86268072 1.522 NM_006183
NTS
neurotensin
chr19_-_3969734 1.522 NM_001348
DAPK3
death-associated protein kinase 3
chr2_+_87755059 1.510 LINC00152
long intergenic non-protein coding RNA 152
chr11_+_62649160 1.509 SLC3A2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
chr11_+_62475165 1.468 GNG3
guanine nucleotide binding protein (G protein), gamma 3
chrX_+_83116153 1.465 NM_021118
CYLC1
cylicin, basic protein of sperm head cytoskeleton 1
chr9_-_113018869 1.463 NM_001244938
NM_003329
TXN

thioredoxin

chr2_-_85641153 1.462 CAPG
capping protein (actin filament), gelsolin-like

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.