Motif ID: MZF1.p2

Z-value: 1.911


Transcription factors associated with MZF1.p2:

Gene SymbolEntrez IDGene Name
MZF1 7593 myeloid zinc finger 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
MZF1hg19_v1_chr19_-_59084089_590841630.272.0e-02Click!


Activity profile for motif MZF1.p2.

activity profile for motif MZF1.p2


Sorted Z-values histogram for motif MZF1.p2

Sorted Z-values for motif MZF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MZF1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_46142955 15.063 NM_001101802
NM_016621
PHF21A

PHD finger protein 21A

chr2_-_145275086 11.791 ZEB2
zinc finger E-box binding homeobox 2
chr8_-_22550456 11.744 EGR3
early growth response 3
chr12_+_58005217 10.687 NM_182947
ARHGEF25
Rho guanine nucleotide exchange factor (GEF) 25
chrX_-_107019001 10.417 NM_198057
TSC22D3
TSC22 domain family, member 3
chr2_+_48757292 9.993 NM_001198595
NM_006873
STON1

stonin 1

chr14_+_24838301 9.965 NM_001198966
NFATC4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
chr19_+_45971249 9.965 NM_001114171
NM_006732
FOSB

FBJ murine osteosarcoma viral oncogene homolog B

chr15_-_40398286 9.229 NM_001003942
NM_001003943
BMF

Bcl2 modifying factor

chr5_+_172484353 8.914 C5orf41
chromosome 5 open reading frame 41
chr6_+_126112057 8.674 NCOA7
nuclear receptor coactivator 7
chr8_-_22550708 8.625 NM_004430
EGR3
early growth response 3
chr5_+_137801178 8.605 NM_001964
EGR1
early growth response 1
chr5_+_137801166 8.565 EGR1
early growth response 1
chr11_+_43963809 8.279 NM_001145033
C11orf96
chromosome 11 open reading frame 96
chr21_+_40177847 8.264 NM_005239
ETS2
v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
chr14_-_24020766 8.074 NM_033400
ZFHX2
zinc finger homeobox 2
chr10_+_114709963 8.000 NM_001146274
NM_001146283
NM_001146284
NM_001146285
NM_001146286
NM_001198525
NM_001198526
NM_001198527
NM_001198528
NM_001198529
NM_001198530
NM_001198531
NM_030756
TCF7L2












transcription factor 7-like 2 (T-cell specific, HMG-box)












chr1_+_201979747 7.880 ELF3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr11_+_5617330 7.867 NM_058166
TRIM6
tripartite motif containing 6
chr3_+_52444514 7.821 NM_016483
NM_173341
PHF7

PHD finger protein 7

chr11_+_130184326 7.727 FLJ34521
uncharacterized LOC646383
chr2_+_48757063 7.624 NM_001198593
STON1-GTF2A1L
STON1-GTF2A1L readthrough
chr2_+_8822112 7.578 NM_002166
ID2
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
chr1_+_160370363 7.518 NM_020335
VANGL2
vang-like 2 (van gogh, Drosophila)
chrX_-_107018889 7.454 TSC22D3
TSC22 domain family, member 3
chr6_-_36164973 7.319


chr14_+_24867926 7.286 NM_025081
NYNRIN
NYN domain and retroviral integrase containing
chr8_-_22549901 7.170 NM_001199880
EGR3
early growth response 3
chr4_-_105416050 7.166 CXXC4
CXXC finger protein 4
chr3_-_187871816 7.121 LPP-AS2
LPP antisense RNA 2 (non-protein coding)
chr9_-_20622433 6.921 MLLT3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr1_+_212781969 6.883 NM_001040619
NM_001206484
NM_001206488
NM_001674
ATF3



activating transcription factor 3



chr5_+_172483285 6.753 NM_001168393
NM_001168394
NM_153607
C5orf41


chromosome 5 open reading frame 41


chr8_-_22550057 6.700 NM_001199881
EGR3
early growth response 3
chr8_-_116681253 6.696 TRPS1
trichorhinophalangeal syndrome I
chr15_-_40398573 6.660 NM_033503
BMF
Bcl2 modifying factor
chr13_+_88324777 6.495 NM_015567
SLITRK5
SLIT and NTRK-like family, member 5
chr19_+_42788605 6.433 NM_015125
CIC
capicua homolog (Drosophila)
chr21_+_40177754 6.428 ETS2
v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
chr19_-_36523540 6.414 NM_001199570
CLIP3
CAP-GLY domain containing linker protein 3
chr11_+_66742747 6.401 NM_001136485
C11orf86
chromosome 11 open reading frame 86
chr1_+_164528586 6.396 NM_001204961
NM_001204963
NM_002585
PBX1


pre-B-cell leukemia homeobox 1


chr19_+_55795766 6.369 BRSK1
BR serine/threonine kinase 1
chr14_+_75745480 6.271 NM_005252
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr2_-_145277568 6.253 ZEB2
zinc finger E-box binding homeobox 2
chr15_+_48010685 6.183 NM_020858
NM_024966
NM_153616
NM_153617
NM_153618
NM_153619
SEMA6D





sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D





chr1_-_53018721 6.181 NM_001009881
NM_015269
ZCCHC11

zinc finger, CCHC domain containing 11

chr2_+_85980600 6.165 NM_032827
ATOH8
atonal homolog 8 (Drosophila)
chr9_-_20622476 6.138 NM_004529
MLLT3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr16_+_56225250 6.115 NM_020988
NM_138736
GNAO1

guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O

chr15_-_40401041 6.085 NM_001003940
BMF
Bcl2 modifying factor
chr17_+_7741630 6.077


chr1_+_212782103 6.058 ATF3
activating transcription factor 3
chr16_+_50776012 6.031 NM_001042412
CYLD
cylindromatosis (turban tumor syndrome)
chr18_-_19748928 5.927 LOC100128893
uncharacterized LOC100128893
chr10_-_98592186 5.923


chr6_-_33714681 5.890 NM_001142883
NM_054111
IP6K3

inositol hexakisphosphate kinase 3

chr16_+_50775960 5.868 NM_001042355
NM_015247
CYLD

cylindromatosis (turban tumor syndrome)

chr19_-_49140569 5.868 NM_001352
DBP
D site of albumin promoter (albumin D-box) binding protein
chr9_+_3526047 5.828


chr3_-_157823815 5.729 NM_001163678
NM_003030
NM_006884
SHOX2


short stature homeobox 2


chr1_-_53018630 5.722 ZCCHC11
zinc finger, CCHC domain containing 11
chr1_-_41950296 5.699 NM_001956
EDN2
endothelin 2
chr2_-_145274916 5.669 ZEB2
zinc finger E-box binding homeobox 2
chr22_-_31688329 5.651 NM_001135911
NM_052880
PIK3IP1

phosphoinositide-3-kinase interacting protein 1

chr17_-_47841517 5.641 NM_030802
FAM117A
family with sequence similarity 117, member A
chr1_+_201979689 5.562 NM_001114309
NM_004433
ELF3

E74-like factor 3 (ets domain transcription factor, epithelial-specific )

chr6_-_111136330 5.561 CDK19
cyclin-dependent kinase 19
chr9_+_126774028 5.537 LHX2
LIM homeobox 2
chr15_-_37392322 5.405 MEIS2
Meis homeobox 2
chrX_+_154997396 5.402 NM_005840
SPRY3
sprouty homolog 3 (Drosophila)
chr1_+_211432693 5.375 NM_001136223
NM_001136224
NM_001136225
RCOR3


REST corepressor 3


chr19_-_46272102 5.348


chr17_+_28256873 5.346 NM_001145053
EFCAB5
EF-hand calcium binding domain 5
chr2_-_145277879 5.326 NM_001171653
NM_014795
ZEB2

zinc finger E-box binding homeobox 2

chr20_-_39317875 5.309 NM_005461
MAFB
v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)
chr14_-_80677839 5.278 NM_001007023
NM_001242502
NM_001242503
NM_013989
DIO2



deiodinase, iodothyronine, type II



chr14_+_24837225 5.222 NM_001198965
NM_004554
NFATC4

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4

chr10_+_99079017 5.162 NM_005479
FRAT1
frequently rearranged in advanced T-cell lymphomas
chr19_-_46476556 5.144 NM_002516
NOVA2
neuro-oncological ventral antigen 2
chr6_-_32119717 5.016 NM_030651
PRRT1
proline-rich transmembrane protein 1
chr2_-_60780767 4.998 BCL11A
B-cell CLL/lymphoma 11A (zinc finger protein)
chr8_-_116681103 4.980 NM_014112
TRPS1
trichorhinophalangeal syndrome I
chr3_-_18466759 4.966 NM_001195470
NM_002971
SATB1

SATB homeobox 1

chr19_+_55795533 4.963 NM_032430
BRSK1
BR serine/threonine kinase 1
chrX_-_106960268 4.943 NM_004089
TSC22D3
TSC22 domain family, member 3
chr2_-_159312955 4.938 NM_001171637
NM_138803
CCDC148

coiled-coil domain containing 148

chr16_-_30042123 4.909 NM_031478
FAM57B
family with sequence similarity 57, member B
chr9_+_109625347 4.904 NM_021224
ZNF462
zinc finger protein 462
chr11_-_64512265 4.838 NM_001098670
RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr17_-_48943672 4.821 NM_001243885
NM_005749
TOB1

transducer of ERBB2, 1

chr1_+_211432855 4.801 RCOR3
REST corepressor 3
chr1_+_167599503 4.769 RCSD1
RCSD domain containing 1
chr7_-_149470294 4.735 NM_207336
ZNF467
zinc finger protein 467
chr2_+_149402321 4.711 EPC2
enhancer of polycomb homolog 2 (Drosophila)
chr10_+_30723050 4.703 MAP3K8
mitogen-activated protein kinase kinase kinase 8
chr1_+_211432726 4.675 RCOR3
REST corepressor 3
chr7_-_27153490 4.675 HOXA3
homeobox A3
chr5_+_121647385 4.664 SNCAIP
synuclein, alpha interacting protein
chr6_-_31869768 4.658 NM_181842
ZBTB12
zinc finger and BTB domain containing 12
chr17_+_42634598 4.650 NM_001466
FZD2
frizzled family receptor 2
chr10_-_64578926 4.637 NM_001136178
EGR2
early growth response 2
chr14_-_54423448 4.606 NM_001202
NM_130850
BMP4

bone morphogenetic protein 4

chr11_+_113930430 4.603 NM_006006
ZBTB16
zinc finger and BTB domain containing 16
chr19_-_36523770 4.583 NM_015526
CLIP3
CAP-GLY domain containing linker protein 3
chr6_-_32119667 4.566 PRRT1
proline-rich transmembrane protein 1
chr11_+_113930296 4.562 ZBTB16
zinc finger and BTB domain containing 16
chr11_+_5617864 4.554 NM_001003818
NM_001198644
NM_001198645
NM_001003819
TRIM6


TRIM6-TRIM34
tripartite motif containing 6


TRIM6-TRIM34 readthrough
chr7_+_96635289 4.531 NM_005222
DLX6
distal-less homeobox 6
chr1_-_151804225 4.516 NM_005060
RORC
RAR-related orphan receptor C
chr20_-_48099178 4.492 NM_004975
KCNB1
potassium voltage-gated channel, Shab-related subfamily, member 1
chr17_-_47841468 4.475 FAM117A
family with sequence similarity 117, member A
chr19_+_49977817 4.468 NM_001204503
FLT3LG
fms-related tyrosine kinase 3 ligand
chr19_-_46272496 4.464 NM_175875
SIX5
SIX homeobox 5
chr1_+_167599329 4.421 NM_052862
RCSD1
RCSD domain containing 1
chr3_+_52444673 4.409 PHF7
PHD finger protein 7
chr19_-_47615802 4.372


chrY_+_59100402 4.293 NM_005840
SPRY3
sprouty homolog 3 (Drosophila)
chr17_+_29718641 4.291 NM_032932
RAB11FIP4
RAB11 family interacting protein 4 (class II)
chr6_-_15248886 4.287


chr16_-_54319966 4.270 IRX3
iroquois homeobox 3
chr6_-_42419782 4.268 NM_033502
TRERF1
transcriptional regulating factor 1
chr6_-_111136616 4.262 CDK19
cyclin-dependent kinase 19
chr4_-_55991746 4.246 NM_002253
KDR
kinase insert domain receptor (a type III receptor tyrosine kinase)
chr2_+_39893021 4.246 NM_152390
TMEM178
transmembrane protein 178
chr8_+_73449625 4.224 NM_004770
KCNB2
potassium voltage-gated channel, Shab-related subfamily, member 2
chr12_-_12715244 4.216 NM_030640
DUSP16
dual specificity phosphatase 16
chr12_-_6798528 4.191 NM_133476
ZNF384
zinc finger protein 384
chr19_+_58907456 4.172 NM_001195135
LOC646862
uncharacterized LOC646862
chr20_-_18038520 4.172 NM_021220
OVOL2
ovo-like 2 (Drosophila)
chr16_-_54320367 4.162 NM_024336
IRX3
iroquois homeobox 3
chr5_+_159343739 4.159 NM_000679
ADRA1B
adrenergic, alpha-1B-, receptor
chr8_-_57123827 4.143 PLAG1
pleiomorphic adenoma gene 1
chr3_-_157823520 4.124


chr11_+_9595183 4.119 NM_003390
WEE1
WEE1 homolog (S. pombe)
chr17_-_56609387 4.104 NM_080415
NM_080416
SEPT4

septin 4

chr6_+_126111782 4.066 NM_001122842
NM_001199621
NM_181782
NCOA7


nuclear receptor coactivator 7


chr1_-_36022938 4.045 KIAA0319L
KIAA0319-like
chr13_-_114018201 4.031 GRTP1
growth hormone regulated TBC protein 1
chr17_+_7788094 4.011 NM_001005271
CHD3
chromodomain helicase DNA binding protein 3
chr19_-_47615485 4.011 ZC3H4
zinc finger CCCH-type containing 4
chr7_+_106809405 3.997 NM_001244262
NM_012257
HBP1

HMG-box transcription factor 1

chr2_+_148778573 3.993 NM_018328
MBD5
methyl-CpG binding domain protein 5
chr12_-_53893195 3.980 NM_001193511
NM_006301
MAP3K12

mitogen-activated protein kinase kinase kinase 12

chr12_-_26277807 3.963 NM_030762
BHLHE41
basic helix-loop-helix family, member e41
chr19_+_55851220 3.958 NM_032701
SUV420H2
suppressor of variegation 4-20 homolog 2 (Drosophila)
chr1_-_204463512 3.955 PIK3C2B
phosphoinositide-3-kinase, class 2, beta polypeptide
chr17_+_40913233 3.934 RAMP2
receptor (G protein-coupled) activity modifying protein 2
chr11_-_119234628 3.931 USP2
ubiquitin specific peptidase 2
chr7_-_107643330 3.927 NM_002291
LAMB1
laminin, beta 1
chr15_-_37392358 3.925 NM_170674
NM_170675
NM_170676
NM_170677
MEIS2



Meis homeobox 2



chr9_-_98279246 3.924 NM_001083602
NM_001083603
PTCH1

patched 1

chr6_+_42750465 3.901 FLJ38717
FLJ38717 protein
chr3_-_187454247 3.883 NM_001130845
BCL6
B-cell CLL/lymphoma 6
chr17_-_74533623 3.874 NM_134268
CYGB
cytoglobin
chr17_-_7197896 3.871 YBX2
Y box binding protein 2
chr17_-_65241305 3.858 NM_014877
HELZ
helicase with zinc finger
chr16_-_54320328 3.845 IRX3
iroquois homeobox 3
chr12_-_6798619 3.800 NM_001039920
NM_001135734
ZNF384

zinc finger protein 384

chr1_-_36023005 3.795 NM_024874
KIAA0319L
KIAA0319-like
chr17_-_38721701 3.779 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chr14_-_23288912 3.761 NM_001126106
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr5_+_42423811 3.745 NM_000163
GHR
growth hormone receptor
chr8_+_72756218 3.718 LOC100132891
uncharacterized LOC100132891
chr19_+_50016606 3.688 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr7_-_27170351 3.685 NM_002141
HOXA4
homeobox A4
chr10_+_76586299 3.684 NM_012330
KAT6B
K(lysine) acetyltransferase 6B
chr2_+_39892637 3.683 NM_001167959
TMEM178
transmembrane protein 178
chr16_+_28505920 3.664 NM_018690
APOBR
apolipoprotein B receptor
chr4_-_174090305 3.648


chr22_-_31742217 3.643 NM_014323
NM_032050
NM_032051
NM_032052
PATZ1



POZ (BTB) and AT hook containing zinc finger 1



chr3_+_38495778 3.640 NM_001106
ACVR2B
activin A receptor, type IIB
chr1_+_211432732 3.616 RCOR3
REST corepressor 3
chr19_-_31840118 3.603 NM_020856
TSHZ3
teashirt zinc finger homeobox 3
chr9_-_14314036 3.603 NM_001190737
NM_005596
NFIB

nuclear factor I/B

chr1_+_205538164 3.601 MFSD4
major facilitator superfamily domain containing 4
chr13_-_67804432 3.591 NM_020403
NM_203487
PCDH9

protocadherin 9

chr2_-_60780404 3.589 NM_018014
NM_022893
NM_138559
BCL11A


B-cell CLL/lymphoma 11A (zinc finger protein)


chr1_+_214161279 3.578 PROX1
prospero homeobox 1
chr6_+_75994713 3.569 LOC100506804
uncharacterized LOC100506804
chr11_+_9595429 3.553 WEE1
WEE1 homolog (S. pombe)
chr6_-_111136407 3.526 NM_015076
CDK19
cyclin-dependent kinase 19
chr1_-_151798552 3.518 NM_001001523
RORC
RAR-related orphan receptor C
chr1_+_61547625 3.513 NM_001134673
NM_005595
NFIA

nuclear factor I/A

chrX_-_119445306 3.510 NM_001104544
NM_001104545
NM_017938
FAM70A


family with sequence similarity 70, member A


chr3_+_184097860 3.508 NM_003741
CHRD
chordin
chr13_-_110438896 3.506 NM_003749
IRS2
insulin receptor substrate 2
chrX_-_119694871 3.483 CUL4B
cullin 4B
chr12_+_54447660 3.477 NM_153633
HOXC4
HOXC6
homeobox C4
homeobox C6
chr2_+_28616360 3.476 FOSL2
FOS-like antigen 2
chr11_+_111783476 3.418 HSPB2-C11orf52
HSPB2
HSPB2-C11orf52 readthrough (non-protein coding)
heat shock 27kDa protein 2
chr16_+_56225301 3.418 GNAO1
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
chr12_+_498513 3.405 NM_001130147
NM_001130148
CCDC77

coiled-coil domain containing 77

chr5_+_10564431 3.394 NM_001164440
ANKRD33B
ankyrin repeat domain 33B
chr12_+_48577365 3.386 NM_001013635
C12orf68
chromosome 12 open reading frame 68
chr1_-_150780705 3.383 NM_000396
CTSK
cathepsin K
chr10_+_102820914 3.358 NM_030929
KAZALD1
Kazal-type serine peptidase inhibitor domain 1
chr7_+_100081549 3.348 NM_173564
NYAP1
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1
chrX_-_106960028 3.343 TSC22D3
TSC22 domain family, member 3

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.68 1.61e-20 GO:0007275 multicellular organismal development
1.86 3.19e-19 GO:0051252 regulation of RNA metabolic process
1.61 5.66e-19 GO:0032502 developmental process
1.88 5.81e-19 GO:0006355 regulation of transcription, DNA-dependent
1.90 2.36e-18 GO:0030154 cell differentiation
1.87 1.48e-17 GO:0048869 cellular developmental process
2.07 2.20e-17 GO:0007399 nervous system development
1.78 9.25e-17 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.65 1.77e-16 GO:0048856 anatomical structure development
1.72 1.95e-16 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.36 2.06e-16 GO:0050794 regulation of cellular process
1.75 3.14e-16 GO:0010556 regulation of macromolecule biosynthetic process
1.69 3.24e-16 GO:0048731 system development
1.32 5.16e-16 GO:0065007 biological regulation
1.73 8.19e-16 GO:0010468 regulation of gene expression
2.34 1.41e-15 GO:0048468 cell development
1.68 5.52e-15 GO:0051171 regulation of nitrogen compound metabolic process
1.69 6.95e-15 GO:0031326 regulation of cellular biosynthetic process
1.33 9.22e-15 GO:0050789 regulation of biological process
1.68 1.49e-14 GO:0009889 regulation of biosynthetic process
1.53 1.02e-12 GO:0080090 regulation of primary metabolic process
1.91 1.61e-12 GO:0009653 anatomical structure morphogenesis
1.55 1.93e-12 GO:0060255 regulation of macromolecule metabolic process
1.52 2.12e-12 GO:0031323 regulation of cellular metabolic process
1.40 3.01e-12 GO:0032501 multicellular organismal process
2.24 3.58e-12 GO:0048699 generation of neurons
2.13 7.59e-12 GO:0006357 regulation of transcription from RNA polymerase II promoter
2.35 2.79e-11 GO:0030182 neuron differentiation
2.13 8.18e-11 GO:0022008 neurogenesis
2.27 1.75e-09 GO:0010628 positive regulation of gene expression
1.43 2.44e-09 GO:0019222 regulation of metabolic process
1.68 4.67e-09 GO:0048513 organ development
2.73 6.20e-09 GO:0048598 embryonic morphogenesis
2.21 7.34e-09 GO:0009790 embryo development
2.28 7.63e-09 GO:0045893 positive regulation of transcription, DNA-dependent
2.44 1.11e-08 GO:0000904 cell morphogenesis involved in differentiation
2.26 4.38e-08 GO:0000902 cell morphogenesis
1.51 9.53e-08 GO:0048518 positive regulation of biological process
2.26 1.25e-07 GO:0048666 neuron development
1.58 1.33e-07 GO:0048523 negative regulation of cellular process
2.08 1.46e-07 GO:0010557 positive regulation of macromolecule biosynthetic process
1.53 1.81e-07 GO:0048522 positive regulation of cellular process
2.33 1.91e-07 GO:0007417 central nervous system development
2.17 2.21e-07 GO:0032989 cellular component morphogenesis
2.13 2.73e-07 GO:0051254 positive regulation of RNA metabolic process
2.04 3.67e-07 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.16 3.92e-07 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.97 5.03e-07 GO:0031328 positive regulation of cellular biosynthetic process
3.00 5.24e-07 GO:0048568 embryonic organ development
2.12 5.59e-07 GO:0010558 negative regulation of macromolecule biosynthetic process
2.35 5.60e-07 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
2.25 6.76e-07 GO:0045892 negative regulation of transcription, DNA-dependent
2.00 7.58e-07 GO:0051173 positive regulation of nitrogen compound metabolic process
2.29 1.06e-06 GO:0031175 neuron projection development
2.15 1.20e-06 GO:0010629 negative regulation of gene expression
1.94 1.24e-06 GO:0009891 positive regulation of biosynthetic process
1.52 1.31e-06 GO:0048519 negative regulation of biological process
3.45 1.43e-06 GO:0048562 embryonic organ morphogenesis
2.20 1.64e-06 GO:0051253 negative regulation of RNA metabolic process
2.25 2.20e-06 GO:0048858 cell projection morphogenesis
2.13 2.29e-06 GO:0009887 organ morphogenesis
2.61 2.31e-06 GO:0001501 skeletal system development
1.91 2.35e-06 GO:0006351 transcription, DNA-dependent
2.54 2.77e-06 GO:0007389 pattern specification process
2.23 3.15e-06 GO:0032990 cell part morphogenesis
2.04 3.38e-06 GO:0045595 regulation of cell differentiation
2.03 3.93e-06 GO:0031327 negative regulation of cellular biosynthetic process
2.02 4.49e-06 GO:0009890 negative regulation of biosynthetic process
2.38 6.50e-06 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
2.45 6.65e-06 GO:0007420 brain development
2.33 6.87e-06 GO:0007409 axonogenesis
2.29 7.08e-06 GO:0048812 neuron projection morphogenesis
1.88 9.22e-06 GO:0040011 locomotion
2.29 9.72e-06 GO:0048667 cell morphogenesis involved in neuron differentiation
1.88 9.83e-06 GO:0009888 tissue development
2.06 1.31e-05 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.68 1.69e-05 GO:0045596 negative regulation of cell differentiation
1.84 1.69e-05 GO:0050793 regulation of developmental process
2.03 2.22e-05 GO:0051172 negative regulation of nitrogen compound metabolic process
1.92 3.03e-05 GO:2000026 regulation of multicellular organismal development
2.75 3.19e-05 GO:0003002 regionalization
1.82 3.46e-05 GO:0010605 negative regulation of macromolecule metabolic process
1.67 4.35e-05 GO:0051239 regulation of multicellular organismal process
1.35 4.40e-05 GO:0023052 signaling
2.22 5.92e-05 GO:0032583 regulation of gene-specific transcription
1.70 6.77e-05 GO:0010604 positive regulation of macromolecule metabolic process
1.98 7.10e-05 GO:0030030 cell projection organization
2.54 8.62e-05 GO:0035295 tube development
2.41 9.90e-05 GO:0051093 negative regulation of developmental process
1.56 1.21e-04 GO:0023051 regulation of signaling
1.64 1.64e-04 GO:0009893 positive regulation of metabolic process
1.74 2.26e-04 GO:0042127 regulation of cell proliferation
1.65 3.01e-04 GO:0031325 positive regulation of cellular metabolic process
1.72 3.86e-04 GO:0032774 RNA biosynthetic process
1.74 6.39e-04 GO:0031324 negative regulation of cellular metabolic process
1.70 6.86e-04 GO:0009892 negative regulation of metabolic process
1.66 9.19e-04 GO:0010646 regulation of cell communication
8.55 2.44e-03 GO:0043401 steroid hormone mediated signaling pathway
2.15 2.70e-03 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
2.19 3.50e-03 GO:0007411 axon guidance
9.36 5.43e-03 GO:0034446 substrate adhesion-dependent cell spreading
2.95 6.54e-03 GO:0048705 skeletal system morphogenesis
3.83 6.57e-03 GO:0009953 dorsal/ventral pattern formation
2.18 7.13e-03 GO:0060284 regulation of cell development
1.30 8.08e-03 GO:0007165 signal transduction
2.08 8.89e-03 GO:0043009 chordate embryonic development
1.77 9.65e-03 GO:0009719 response to endogenous stimulus
4.44 9.82e-03 GO:0021510 spinal cord development
2.05 1.21e-02 GO:0009792 embryo development ending in birth or egg hatching
1.80 1.35e-02 GO:0009725 response to hormone stimulus
3.61 1.48e-02 GO:0048565 digestive tract development
3.45 1.49e-02 GO:0048706 embryonic skeletal system development
2.03 1.51e-02 GO:0060429 epithelium development
3.41 1.78e-02 GO:0021915 neural tube development
3.41 1.78e-02 GO:0055123 digestive system development
3.24 2.01e-02 GO:0030326 embryonic limb morphogenesis
3.24 2.01e-02 GO:0035113 embryonic appendage morphogenesis
3.00 2.26e-02 GO:0007611 learning or memory
1.91 2.32e-02 GO:0048646 anatomical structure formation involved in morphogenesis
3.87 2.41e-02 GO:0048704 embryonic skeletal system morphogenesis
2.88 2.63e-02 GO:0050890 cognition
2.49 2.67e-02 GO:0035239 tube morphogenesis
1.94 3.20e-02 GO:0016477 cell migration
3.02 3.42e-02 GO:0035107 appendage morphogenesis
3.02 3.42e-02 GO:0035108 limb morphogenesis
3.10 3.81e-02 GO:0030324 lung development
5.01 3.94e-02 GO:0048864 stem cell development
1.82 4.60e-02 GO:0006935 chemotaxis
1.82 4.60e-02 GO:0042330 taxis

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
3.33 5.15e-06 GO:0034703 cation channel complex
1.26 6.65e-06 GO:0005634 nucleus
2.70 2.50e-05 GO:0034702 ion channel complex
6.08 2.21e-04 GO:0034704 calcium channel complex
2.05 4.76e-04 GO:0043005 neuron projection
1.98 1.56e-03 GO:0045202 synapse
2.84 7.10e-03 GO:0044420 extracellular matrix part
6.11 7.45e-03 GO:0005891 voltage-gated calcium channel complex
1.35 9.06e-03 GO:0044459 plasma membrane part
1.94 3.04e-02 GO:0005578 proteinaceous extracellular matrix
2.09 3.57e-02 GO:0000785 chromatin

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
3.17 1.31e-29 GO:0043565 sequence-specific DNA binding
2.69 1.88e-28 GO:0001071 nucleic acid binding transcription factor activity
2.69 1.88e-28 GO:0003700 sequence-specific DNA binding transcription factor activity
1.89 9.69e-23 GO:0003677 DNA binding
2.19 4.32e-15 GO:0030528 transcription regulator activity
1.52 3.11e-12 GO:0003676 nucleic acid binding
2.89 6.54e-06 GO:0010843 promoter binding
1.12 9.87e-06 GO:0005488 binding
2.78 1.90e-05 GO:0000975 regulatory region DNA binding
2.78 1.90e-05 GO:0001067 regulatory region nucleic acid binding
2.78 1.90e-05 GO:0044212 transcription regulatory region DNA binding
1.48 2.10e-05 GO:0008270 zinc ion binding
1.42 1.05e-04 GO:0046914 transition metal ion binding
2.24 3.32e-04 GO:0016563 transcription activator activity
2.59 8.55e-04 GO:0003682 chromatin binding
4.40 1.02e-03 GO:0003707 steroid hormone receptor activity
2.82 1.24e-03 GO:0022843 voltage-gated cation channel activity
4.16 2.14e-03 GO:0004879 ligand-dependent nuclear receptor activity
1.26 3.73e-03 GO:0046872 metal ion binding
1.25 4.25e-03 GO:0043167 ion binding
2.09 6.19e-03 GO:0016564 transcription repressor activity
1.25 6.70e-03 GO:0043169 cation binding
1.93 1.20e-02 GO:0000988 protein binding transcription factor activity
1.93 1.20e-02 GO:0000989 transcription factor binding transcription factor activity
1.90 1.61e-02 GO:0005216 ion channel activity
2.32 2.19e-02 GO:0005244 voltage-gated ion channel activity
2.32 2.19e-02 GO:0022832 voltage-gated channel activity
1.87 2.36e-02 GO:0022838 substrate-specific channel activity
1.90 2.40e-02 GO:0003712 transcription cofactor activity
1.97 3.49e-02 GO:0022836 gated channel activity
1.81 4.91e-02 GO:0015267 channel activity