Motif ID: MYFfamily.p2

Z-value: 1.947


Transcription factors associated with MYFfamily.p2:

Gene SymbolEntrez IDGene Name
MYF5 4617 myogenic factor 5
MYF6 4618 myogenic factor 6 (herculin)
MYOD1 4654 myogenic differentiation 1
MYOG 4656 myogenin (myogenic factor 4)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
MYOD1hg19_v1_chr11_+_17741109_177413290.774.0e-16Click!
MYOGhg19_v1_chr1_-_203055088_2030551650.761.8e-15Click!


Activity profile for motif MYFfamily.p2.

activity profile for motif MYFfamily.p2


Sorted Z-values histogram for motif MYFfamily.p2

Sorted Z-values for motif MYFfamily.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MYFfamily.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_+_96635289 23.538 NM_005222
DLX6
distal-less homeobox 6
chr16_-_31214054 20.857 NM_013258
NM_145182
PYCARD

PYD and CARD domain containing

chrX_-_38079980 19.506 NM_001170750
NM_001170751
NM_001170752
NM_006307
SRPX



sushi-repeat containing protein, X-linked



chrX_+_75648045 19.373 NM_020932
MAGEE1
melanoma antigen family E, 1
chr5_+_137801178 17.349 NM_001964
EGR1
early growth response 1
chr6_+_107811272 15.760 NM_018013
SOBP
sine oculis binding protein homolog (Drosophila)
chr5_+_137774632 15.466 NM_016606
REEP2
receptor accessory protein 2
chrX_-_84634664 13.501 POF1B
premature ovarian failure, 1B
chrX_-_84634742 13.025 NM_024921
POF1B
premature ovarian failure, 1B
chr5_-_139422725 12.874 NRG2
neuregulin 2
chr19_+_41699076 12.861 NM_030622
CYP2S1
cytochrome P450, family 2, subfamily S, polypeptide 1
chr6_+_45390284 12.662 RUNX2
runt-related transcription factor 2
chr15_-_48470453 12.167 NM_016132
MYEF2
myelin expression factor 2
chr6_+_45390376 12.011 RUNX2
runt-related transcription factor 2
chr2_+_217498082 11.943 NM_000597
IGFBP2
insulin-like growth factor binding protein 2, 36kDa
chr5_+_137774897 11.907 REEP2
receptor accessory protein 2
chr2_+_217498205 11.574 IGFBP2
insulin-like growth factor binding protein 2, 36kDa
chr2_-_160654668 11.461 CD302
CD302 molecule
chr4_-_57976516 11.435 IGFBP7
insulin-like growth factor binding protein 7
chr4_-_57976550 11.392 NM_001253835
NM_001553
IGFBP7

insulin-like growth factor binding protein 7

chrX_-_84634396 11.381 POF1B
premature ovarian failure, 1B
chr19_+_41699140 11.126 CYP2S1
cytochrome P450, family 2, subfamily S, polypeptide 1
chr5_+_137801166 11.019 EGR1
early growth response 1
chr8_-_23712297 10.776 NM_003155
STC1
stanniocalcin 1
chrX_-_48693934 10.572 NM_013271
PCSK1N
proprotein convertase subtilisin/kexin type 1 inhibitor
chr16_-_31214003 10.223 PYCARD
PYD and CARD domain containing
chr22_+_21738039 9.631 NM_001128635
RIMBP3B
RIMS binding protein 3B
chr6_+_99282597 9.610 POU3F2
POU class 3 homeobox 2
chr3_+_71803200 9.591 NM_018971
GPR27
G protein-coupled receptor 27
chr22_-_20792107 9.585 NM_153334
NM_182895
SCARF2

scavenger receptor class F, member 2

chr10_+_64133915 9.581 NM_014951
NM_199450
NM_199451
ZNF365


zinc finger protein 365


chr13_-_72440143 9.217 DACH1
dachshund homolog 1 (Drosophila)
chr5_+_140254930 9.162 NM_018903
NM_031864
PCDHA12

protocadherin alpha 12

chr15_-_48470319 9.053 MYEF2
myelin expression factor 2
chr2_-_227664330 9.046 IRS1
insulin receptor substrate 1
chr20_+_45523247 8.886 NM_005244
NM_172110
EYA2

eyes absent homolog 2 (Drosophila)

chr5_-_146258143 8.844 NM_004576
NM_181675
NM_001127381
PPP2R2B


protein phosphatase 2, regulatory subunit B, beta


chr19_+_36359346 8.516 NM_001024807
NM_005166
APLP1

amyloid beta (A4) precursor-like protein 1

chr17_+_60705051 8.386 MRC2
mannose receptor, C type 2
chr10_-_90967048 8.332 NM_003956
CH25H
cholesterol 25-hydroxylase
chr12_-_89745753 8.277 DUSP6
dual specificity phosphatase 6
chr5_+_140346289 8.267 NM_031883
PCDHAC2
protocadherin alpha subfamily C, 2
chr12_-_76425375 8.200 NM_007350
PHLDA1
pleckstrin homology-like domain, family A, member 1
chr2_+_132285469 8.064 NM_138770
CCDC74A
coiled-coil domain containing 74A
chr19_-_51504799 7.925 NM_007196
NM_144505
NM_144506
NM_144507
KLK8



kallikrein-related peptidase 8



chr17_+_60705042 7.895 MRC2
mannose receptor, C type 2
chr20_+_45523505 7.840 EYA2
eyes absent homolog 2 (Drosophila)
chr13_+_78271820 7.782 NM_001242868
SLAIN1
SLAIN motif family, member 1
chr10_-_30316338 7.731 KIAA1462
KIAA1462
chr17_-_27949814 7.647 CORO6
coronin 6
chr22_-_21905372 7.558 NM_001128635
RIMBP3B
RIMS binding protein 3B
chr19_-_7701852 7.542


chr20_+_2673193 7.541 NM_001110514
EBF4
early B-cell factor 4
chr20_+_45523523 7.535 EYA2
eyes absent homolog 2 (Drosophila)
chr4_-_57976355 7.457 IGFBP7
insulin-like growth factor binding protein 7
chr2_-_160654736 7.451 NM_001198763
NM_001198764
NM_014880
CD302


CD302 molecule


chr11_-_57335080 7.437 NM_004223
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr22_-_20792047 7.434 SCARF2
scavenger receptor class F, member 2
chr1_-_153433104 7.391 NM_002963
S100A7
S100 calcium binding protein A7
chr19_+_8274179 7.276 NM_024552
CERS4
ceramide synthase 4
chr19_-_36019194 7.268 NM_001166034
NM_001166035
NM_198538
SBSN


suprabasin


chr12_+_132312917 7.113 NM_016155
MMP17
matrix metallopeptidase 17 (membrane-inserted)
chr15_+_48413168 7.072 NM_205850
SLC24A5
solute carrier family 24, member 5
chr12_+_569542 7.045 NM_173593
B4GALNT3
beta-1,4-N-acetyl-galactosaminyl transferase 3
chr1_+_154301219 6.868 ATP8B2
ATPase, class I, type 8B, member 2
chr4_+_7194317 6.797 NM_020777
SORCS2
sortilin-related VPS10 domain containing receptor 2
chrX_+_117629871 6.712 NM_144658
DOCK11
dedicator of cytokinesis 11
chrX_-_135849356 6.711 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr9_-_38424422 6.697 NM_001007563
IGFBPL1
insulin-like growth factor binding protein-like 1
chr5_+_113698015 6.650 NM_021614
KCNN2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr11_+_66790815 6.494 NM_177963
SYT12
synaptotagmin XII
chr12_-_89745997 6.396 DUSP6
dual specificity phosphatase 6
chr7_-_27239724 6.382 NM_000522
HOXA13
homeobox A13
chr12_-_76424474 6.376 PHLDA1
pleckstrin homology-like domain, family A, member 1
chr14_+_65007418 6.277 HSPA2
heat shock 70kDa protein 2
chr13_-_72440557 6.241 DACH1
dachshund homolog 1 (Drosophila)
chr9_+_4490193 6.231 NM_004170
SLC1A1
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
chrX_+_21392396 6.212 NM_001168647
NM_001168648
NM_001168649
NM_014927
CNKSR2



connector enhancer of kinase suppressor of Ras 2



chr2_-_172967234 6.188 NM_004405
DLX2
distal-less homeobox 2
chr17_-_39743085 6.158 NM_000526
KRT14
keratin 14
chr5_+_156887204 6.145 NIPAL4
NIPA-like domain containing 4
chr3_+_85008031 6.135 NM_001167674
NM_001167675
CADM2

cell adhesion molecule 2

chr2_-_39187477 6.127 LOC375196
uncharacterized LOC375196
chr17_+_29248697 6.121 NM_018404
ADAP2
ArfGAP with dual PH domains 2
chr2_-_130902568 6.064 NM_207310
CCDC74B
coiled-coil domain containing 74B
chr6_+_5085719 6.058 NM_001145115
PPP1R3G
protein phosphatase 1, regulatory subunit 3G
chr10_+_12391471 6.041 NM_020397
NM_153498
CAMK1D

calcium/calmodulin-dependent protein kinase ID

chr19_-_37341168 6.021 NM_001242801
ZNF790
zinc finger protein 790
chr19_-_37341688 5.959 NM_001242800
ZNF790
zinc finger protein 790
chr1_+_201252579 5.935 NM_000299
NM_001005337
PKP1

plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)

chr2_+_105471745 5.925 NM_006236
POU3F3
POU class 3 homeobox 3
chr19_-_10047014 5.912 NM_058164
OLFM2
olfactomedin 2
chr12_-_76425207 5.901 PHLDA1
pleckstrin homology-like domain, family A, member 1
chrX_-_92928566 5.851 NM_004538
NAP1L3
nucleosome assembly protein 1-like 3
chr5_+_113698304 5.846 KCNN2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr5_+_140346053 5.833 PCDHAC2
protocadherin alpha subfamily C, 2
chr6_+_124125068 5.793 NM_001040214
NM_153355
NKAIN2

Na+/K+ transporting ATPase interacting 2

chr14_+_65007163 5.756 NM_021979
HSPA2
heat shock 70kDa protein 2
chr2_+_185463235 5.717 ZNF804A
zinc finger protein 804A
chr17_+_38599651 5.713 NM_001552
IGFBP4
insulin-like growth factor binding protein 4
chr1_-_72748147 5.705 NM_173808
NEGR1
neuronal growth regulator 1
chr10_+_12391728 5.703 CAMK1D
calcium/calmodulin-dependent protein kinase ID
chr18_-_22931970 5.666 ZNF521
zinc finger protein 521
chr5_-_134914447 5.657 CXCL14
chemokine (C-X-C motif) ligand 14
chr17_-_39183453 5.461 NM_031957
KRTAP1-5
keratin associated protein 1-5
chr10_-_5541401 5.398 NM_017422
CALML5
calmodulin-like 5
chr20_-_23066828 5.383 NM_012072
CD93
CD93 molecule
chr19_+_37341259 5.366 NM_003419
ZNF345
zinc finger protein 345
chr3_+_111717585 5.347 NM_001008272
NM_013259
TAGLN3

transgelin 3

chr3_-_158390266 5.324 NM_020169
LXN
latexin
chr11_-_9113092 5.309 NM_001170690
NM_020974
SCUBE2

signal peptide, CUB domain, EGF-like 2

chr2_-_160919120 5.300 NM_001007267
NM_001195641
NM_007366
PLA2R1


phospholipase A2 receptor 1, 180kDa


chr3_+_186648273 5.260 NM_173216
NM_173217
ST6GAL1

ST6 beta-galactosamide alpha-2,6-sialyltranferase 1

chr2_+_79740059 5.224 NM_001164883
NM_004389
CTNNA2

catenin (cadherin-associated protein), alpha 2

chr17_+_60704747 5.167 NM_006039
MRC2
mannose receptor, C type 2
chr11_-_119187811 5.106 NM_006500
MCAM
melanoma cell adhesion molecule
chr7_-_137531585 5.098 NM_004717
DGKI
diacylglycerol kinase, iota
chr21_+_46825291 5.094


chr14_+_59104736 5.087 NM_001079520
NM_016651
DACT1

dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)

chr11_-_130298502 5.078 NM_007037
ADAMTS8
ADAM metallopeptidase with thrombospondin type 1 motif, 8
chr3_+_111718006 5.046 NM_001008273
TAGLN3
transgelin 3
chr8_+_31497267 5.045 NM_013962
NRG1
neuregulin 1
chr4_-_6202251 4.954 NM_001099433
NM_144720
JAKMIP1

janus kinase and microtubule interacting protein 1

chr2_+_37571752 4.945 NM_012413
QPCT
glutaminyl-peptide cyclotransferase
chr1_+_171810611 4.914 NM_001136127
NM_015569
DNM3

dynamin 3

chr5_-_139422805 4.887 NM_001184935
NM_004883
NM_013981
NM_013982
NM_013983
NRG2




neuregulin 2




chr19_+_51628136 4.852 NM_001198558
NM_014441
SIGLEC9

sialic acid binding Ig-like lectin 9

chr6_+_31691120 4.795 NM_025260
NM_138272
NM_138273
NM_138274
NM_138275
NM_138277
C6orf25





chromosome 6 open reading frame 25





chr9_-_120177307 4.755 NM_014010
ASTN2
astrotactin 2
chr3_-_99833348 4.733 NM_001042459
NM_182909
FILIP1L

filamin A interacting protein 1-like

chr1_-_11918889 4.716 NM_002521
NPPB
natriuretic peptide B
chr17_+_19437140 4.712 NM_018242
SLC47A1
solute carrier family 47, member 1
chr5_+_52776479 4.712 FST
follistatin
chr3_+_3841079 4.701 NM_020873
LRRN1
leucine rich repeat neuronal 1
chr6_-_32191779 4.699 NM_004557
NOTCH4
notch 4
chr3_-_64211111 4.661 NM_198859
PRICKLE2
prickle homolog 2 (Drosophila)
chr2_-_160918935 4.641 PLA2R1
phospholipase A2 receptor 1, 180kDa
chr19_+_37341724 4.637 NM_001242472
NM_001242474
ZNF345

zinc finger protein 345

chr8_-_140715234 4.594 NM_016601
KCNK9
potassium channel, subfamily K, member 9
chr5_+_156887026 4.586 NM_001099287
NM_001172292
NIPAL4

NIPA-like domain containing 4

chr2_+_176957448 4.573 NM_000523
HOXD13
homeobox D13
chr9_-_101470836 4.569 NM_005458
GABBR2
gamma-aminobutyric acid (GABA) B receptor, 2
chr8_-_22550708 4.555 NM_004430
EGR3
early growth response 3
chr10_-_79397470 4.553 KCNMA1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr8_+_104383785 4.520 NM_138455
CTHRC1
collagen triple helix repeat containing 1
chr10_-_17496175 4.466 NM_001004470
ST8SIA6
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6
chr11_-_627172 4.461 NM_021920
SCT
secretin
chr1_-_31712399 4.458 NKAIN1
Na+/K+ transporting ATPase interacting 1
chr2_-_47797469 4.401 NM_022055
KCNK12
potassium channel, subfamily K, member 12
chrX_+_134555867 4.348 LINC00086
long intergenic non-protein coding RNA 86
chr19_-_39805975 4.344 NM_020862
LRFN1
leucine rich repeat and fibronectin type III domain containing 1
chr2_+_219724545 4.332 NM_006522
WNT6
wingless-type MMTV integration site family, member 6
chr9_-_120177326 4.331 ASTN2
astrotactin 2
chr7_-_83278478 4.317 NM_012431
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr2_-_227663454 4.307 NM_005544
IRS1
insulin receptor substrate 1
chr18_-_22932109 4.283 NM_015461
ZNF521
zinc finger protein 521
chr9_-_140063854 4.256


chr19_-_14048877 4.215 PODNL1
podocan-like 1
chr12_-_6665220 4.214 NM_001039670
NM_001193457
NM_080730
IFFO1


intermediate filament family orphan 1


chrX_-_153095996 4.210 NM_032512
PDZD4
PDZ domain containing 4
chr11_+_94277566 4.207 FUT4
fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
chr5_-_147162264 4.203 JAKMIP2
janus kinase and microtubule interacting protein 2
chr11_-_130298305 4.198 ADAMTS8
ADAM metallopeptidase with thrombospondin type 1 motif, 8
chr12_+_103352021 4.192 ASCL1
achaete-scute complex homolog 1 (Drosophila)
chr10_-_79397546 4.175 NM_001014797
NM_001161352
NM_001161353
NM_002247
KCNMA1



potassium large conductance calcium-activated channel, subfamily M, alpha member 1



chr10_-_79397394 4.168 KCNMA1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr18_+_10454542 4.157 APCDD1
adenomatosis polyposis coli down-regulated 1
chr1_+_221053000 4.135 HLX
H2.0-like homeobox
chr3_+_139654206 4.135 CLSTN2
calsyntenin 2
chr3_+_139654001 4.132 NM_022131
CLSTN2
calsyntenin 2
chr19_-_47137938 4.126 NM_033258
GNG8
guanine nucleotide binding protein (G protein), gamma 8
chr12_-_95044205 4.117 NM_020698
TMCC3
transmembrane and coiled-coil domain family 3
chr2_-_193059599 4.102 NM_016192
TMEFF2
transmembrane protein with EGF-like and two follistatin-like domains 2
chr16_-_4588738 4.090 NM_001199055
NM_001199056
NM_013399
C16orf5


chromosome 16 open reading frame 5


chr8_+_1950304 4.054 KBTBD11
kelch repeat and BTB (POZ) domain containing 11
chr14_-_27066959 4.051 NM_002515
NM_006489
NM_006491
NOVA1


neuro-oncological ventral antigen 1


chr17_+_7452374 4.047 NM_172089
NM_003809
TNFSF12-TNFSF13
TNFSF12
TNFSF12-TNFSF13 readthrough
tumor necrosis factor (ligand) superfamily, member 12
chr2_-_172967627 4.030 DLX2
distal-less homeobox 2
chr2_+_30454396 4.026 NM_030915
LBH
limb bud and heart development homolog (mouse)
chr9_+_33795558 4.023 NM_002771
PRSS3
protease, serine, 3
chr21_-_28217272 4.006 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr17_+_61554420 4.001 NM_000789
ACE
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
chr16_-_14788429 3.980 NM_003561
PLA2G10
phospholipase A2, group X
chr19_+_45409003 3.976 NM_000041
APOE
apolipoprotein E
chr11_-_12030128 3.947 NM_001018057
DKK3
dickkopf 3 homolog (Xenopus laevis)
chr1_-_31712733 3.946 NM_024522
NKAIN1
Na+/K+ transporting ATPase interacting 1
chr5_+_52776263 3.931 NM_006350
NM_013409
FST

follistatin

chr22_+_24115035 3.909 NM_005940
MMP11
matrix metallopeptidase 11 (stromelysin 3)
chr3_+_186648515 3.903 ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr2_-_48982809 3.862 NM_000233
LHCGR
luteinizing hormone/choriogonadotropin receptor
chr2_-_172967014 3.843 DLX2
distal-less homeobox 2
chr14_-_75078669 3.815 NM_000428
LTBP2
latent transforming growth factor beta binding protein 2
chr5_-_141993691 3.807 NM_033137
FGF1
fibroblast growth factor 1 (acidic)
chr1_-_115632047 3.793 NM_005725
TSPAN2
tetraspanin 2
chrX_-_107979606 3.777 NM_003604
IRS4
insulin receptor substrate 4
chr10_+_52834233 3.761 NM_006258
PRKG1
protein kinase, cGMP-dependent, type I
chr5_-_147162175 3.758 JAKMIP2
janus kinase and microtubule interacting protein 2
chr3_+_140770412 3.729 SPSB4
splA/ryanodine receptor domain and SOCS box containing 4
chr19_-_15343194 3.723 NM_024794
EPHX3
epoxide hydrolase 3
chr15_+_81426605 3.723 NM_173528
C15orf26
chromosome 15 open reading frame 26

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.49 9.21e-21 GO:0032501 multicellular organismal process
1.61 1.32e-19 GO:0032502 developmental process
1.65 1.52e-19 GO:0007275 multicellular organismal development
2.11 1.84e-19 GO:0007399 nervous system development
1.72 1.27e-18 GO:0048731 system development
1.67 2.98e-18 GO:0048856 anatomical structure development
2.46 8.13e-14 GO:0030182 neuron differentiation
2.32 1.34e-12 GO:0007155 cell adhesion
2.32 1.34e-12 GO:0022610 biological adhesion
1.71 1.04e-11 GO:0030154 cell differentiation
2.50 1.23e-11 GO:0048666 neuron development
2.17 2.04e-11 GO:0048699 generation of neurons
1.68 4.59e-11 GO:0048869 cellular developmental process
1.83 5.46e-11 GO:0009653 anatomical structure morphogenesis
2.10 7.83e-11 GO:0022008 neurogenesis
2.09 1.40e-10 GO:0048468 cell development
1.63 4.08e-08 GO:0048513 organ development
1.41 7.07e-08 GO:0023052 signaling
2.44 1.03e-07 GO:0048667 cell morphogenesis involved in neuron differentiation
2.34 1.05e-07 GO:0019226 transmission of nerve impulse
2.34 1.05e-07 GO:0035637 multicellular organismal signaling
2.39 2.17e-07 GO:0048812 neuron projection morphogenesis
1.62 2.31e-07 GO:0007166 cell surface receptor linked signaling pathway
2.02 2.56e-07 GO:0007267 cell-cell signaling
2.31 2.82e-07 GO:0031175 neuron projection development
2.28 4.60e-07 GO:0000904 cell morphogenesis involved in differentiation
1.83 1.36e-06 GO:0007154 cell communication
2.06 2.56e-06 GO:0030030 cell projection organization
2.32 3.85e-06 GO:0007409 axonogenesis
2.20 4.04e-06 GO:0048858 cell projection morphogenesis
2.28 5.73e-06 GO:0007268 synaptic transmission
2.18 5.77e-06 GO:0032990 cell part morphogenesis
2.04 7.38e-06 GO:0032989 cellular component morphogenesis
2.06 9.37e-06 GO:0000902 cell morphogenesis
2.10 1.13e-05 GO:0007186 G-protein coupled receptor protein signaling pathway
1.36 6.31e-05 GO:0007165 signal transduction
2.41 8.65e-05 GO:0007610 behavior
1.77 2.53e-04 GO:0009888 tissue development
1.43 3.77e-04 GO:0042221 response to chemical stimulus
2.26 5.83e-04 GO:0007411 axon guidance
3.06 6.39e-04 GO:0007156 homophilic cell adhesion
2.32 7.00e-04 GO:0016337 cell-cell adhesion
1.73 9.03e-04 GO:0040011 locomotion
13.22 1.14e-03 GO:0006198 cAMP catabolic process
3.45 1.14e-03 GO:0007586 digestion
4.80 1.29e-03 GO:0007422 peripheral nervous system development
1.94 2.34e-03 GO:0007417 central nervous system development
1.55 3.44e-03 GO:0051239 regulation of multicellular organismal process
6.94 4.08e-03 GO:0046058 cAMP metabolic process
11.57 4.31e-03 GO:0009214 cyclic nucleotide catabolic process
1.19 8.76e-03 GO:0050896 response to stimulus
4.07 1.14e-02 GO:0007190 activation of adenylate cyclase activity
4.00 1.44e-02 GO:0031281 positive regulation of cyclase activity
4.00 1.44e-02 GO:0045762 positive regulation of adenylate cyclase activity
1.87 1.62e-02 GO:0030001 metal ion transport
2.09 1.89e-02 GO:0051046 regulation of secretion
2.12 2.21e-02 GO:0019932 second-messenger-mediated signaling
1.61 2.26e-02 GO:0006811 ion transport
3.86 2.28e-02 GO:0051349 positive regulation of lyase activity
1.77 2.34e-02 GO:0009887 organ morphogenesis
2.05 2.49e-02 GO:0044057 regulation of system process
1.60 2.95e-02 GO:0050793 regulation of developmental process
2.54 3.68e-02 GO:0006813 potassium ion transport
2.11 4.28e-02 GO:0007423 sensory organ development
3.05 4.46e-02 GO:0048839 inner ear development
1.56 4.47e-02 GO:0009605 response to external stimulus
2.77 4.48e-02 GO:0050890 cognition
1.41 4.69e-02 GO:0003008 system process

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.88 2.75e-20 GO:0005576 extracellular region
2.22 6.26e-17 GO:0044421 extracellular region part
3.12 5.44e-16 GO:0031012 extracellular matrix
1.49 1.10e-15 GO:0005886 plasma membrane
1.48 2.20e-15 GO:0071944 cell periphery
3.28 3.20e-15 GO:0005578 proteinaceous extracellular matrix
1.73 6.21e-15 GO:0044459 plasma membrane part
1.37 3.57e-13 GO:0031224 intrinsic to membrane
1.32 1.27e-12 GO:0044425 membrane part
1.92 1.79e-12 GO:0031226 intrinsic to plasma membrane
1.92 4.10e-12 GO:0005887 integral to plasma membrane
1.35 2.18e-11 GO:0016021 integral to membrane
1.25 2.91e-10 GO:0016020 membrane
1.97 5.07e-08 GO:0005615 extracellular space
2.41 1.21e-05 GO:0044456 synapse part
2.67 2.05e-05 GO:0034702 ion channel complex
2.15 3.05e-05 GO:0045202 synapse
3.28 6.82e-05 GO:0044420 extracellular matrix part
3.75 5.64e-04 GO:0005604 basement membrane
2.56 1.41e-03 GO:0005882 intermediate filament
1.99 1.84e-03 GO:0009986 cell surface
2.63 6.18e-03 GO:0034703 cation channel complex
2.29 8.13e-03 GO:0045111 intermediate filament cytoskeleton
3.01 1.24e-02 GO:0008021 synaptic vesicle
3.01 2.11e-02 GO:0045095 keratin filament
1.66 2.38e-02 GO:0030054 cell junction

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
1.94 5.71e-06 GO:0005509 calcium ion binding
2.36 2.74e-05 GO:0022836 gated channel activity
2.45 3.29e-05 GO:0005261 cation channel activity
2.15 6.59e-05 GO:0005216 ion channel activity
2.11 1.10e-04 GO:0022838 substrate-specific channel activity
2.05 2.91e-04 GO:0015267 channel activity
1.48 3.14e-04 GO:0004872 receptor activity
2.04 3.15e-04 GO:0022803 passive transmembrane transporter activity
7.71 1.31e-03 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
1.70 1.45e-03 GO:0015075 ion transmembrane transporter activity
6.04 3.74e-03 GO:0005520 insulin-like growth factor binding
2.92 4.35e-03 GO:0008201 heparin binding
3.28 6.32e-03 GO:0042165 neurotransmitter binding
1.37 6.42e-03 GO:0004871 signal transducer activity
1.37 6.42e-03 GO:0060089 molecular transducer activity
9.25 6.50e-03 GO:0008191 metalloendopeptidase inhibitor activity
9.25 6.50e-03 GO:0048551 metalloenzyme inhibitor activity
1.76 7.26e-03 GO:0008324 cation transmembrane transporter activity
1.49 7.40e-03 GO:0005215 transporter activity
8.41 1.35e-02 GO:0010576 metalloenzyme regulator activity
2.52 1.38e-02 GO:0005539 glycosaminoglycan binding
1.90 1.41e-02 GO:0030246 carbohydrate binding
1.51 2.02e-02 GO:0022892 substrate-specific transporter activity
3.26 2.18e-02 GO:0030594 neurotransmitter receptor activity
1.55 2.26e-02 GO:0022891 substrate-specific transmembrane transporter activity
1.53 2.52e-02 GO:0022857 transmembrane transporter activity
1.45 2.79e-02 GO:0004888 transmembrane receptor activity
2.57 3.16e-02 GO:0005267 potassium channel activity
5.14 4.68e-02 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity