Motif ID: MTF1.p2

Z-value: 1.886


Transcription factors associated with MTF1.p2:

Gene SymbolEntrez IDGene Name
MTF1 4520 metal-regulatory transcription factor 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
MTF1hg19_v1_chr1_-_38325224_383252920.065.9e-01Click!


Activity profile for motif MTF1.p2.

activity profile for motif MTF1.p2


Sorted Z-values histogram for motif MTF1.p2

Sorted Z-values for motif MTF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MTF1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_+_71803200 20.687 NM_018971
GPR27
G protein-coupled receptor 27
chr13_-_20767100 17.582 NM_004004
GJB2
gap junction protein, beta 2, 26kDa
chr19_+_15218141 16.401 NM_033025
SYDE1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr13_-_20806533 15.058 NM_001110219
NM_001110220
NM_001110221
GJB6


gap junction protein, beta 6, 30kDa


chr1_+_92495484 14.734 NM_173567
EPHX4
epoxide hydrolase 4
chr2_+_217498082 14.171 NM_000597
IGFBP2
insulin-like growth factor binding protein 2, 36kDa
chr10_-_43762366 12.612 NM_145313
RASGEF1A
RasGEF domain family, member 1A
chrX_+_102631408 12.404 NGFRAP1
nerve growth factor receptor (TNFRSF16) associated protein 1
chr13_-_20767036 12.089 GJB2
gap junction protein, beta 2, 26kDa
chr7_-_44365019 11.512 NM_001220
NM_172078
NM_172079
NM_172080
NM_172081
NM_172082
NM_172083
NM_172084
CAMK2B







calcium/calmodulin-dependent protein kinase II beta







chr17_+_60705051 11.433 MRC2
mannose receptor, C type 2
chr17_+_60705042 11.134 MRC2
mannose receptor, C type 2
chr2_+_217498205 10.515 IGFBP2
insulin-like growth factor binding protein 2, 36kDa
chr11_+_129245834 10.429 NM_003658
BARX2
BARX homeobox 2
chr13_+_37006408 10.336 NM_001111045
NM_003914
CCNA1

cyclin A1

chr2_-_224903933 10.033 NM_001136528
NM_006216
SERPINE2

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2

chr13_+_37005966 9.288 NM_001111046
NM_001111047
CCNA1

cyclin A1

chr10_-_44144151 9.267 NM_001005368
ZNF32
zinc finger protein 32
chr15_-_48470453 9.117 NM_016132
MYEF2
myelin expression factor 2
chr17_+_74380676 9.051 NM_001142601
NM_021972
NM_182965
SPHK1


sphingosine kinase 1


chr8_-_121824287 9.046 NM_021021
SNTB1
syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
chr12_+_569542 8.887 NM_173593
B4GALNT3
beta-1,4-N-acetyl-galactosaminyl transferase 3
chr12_-_45270157 8.820 NM_001145108
NM_006159
NELL2

NEL-like 2 (chicken)

chr3_-_48632592 8.723 NM_000094
COL7A1
collagen, type VII, alpha 1
chr7_+_121513158 8.586 NM_001206838
NM_001206839
NM_002851
PTPRZ1


protein tyrosine phosphatase, receptor-type, Z polypeptide 1


chr3_+_190231839 8.498 NM_001167928
NM_001167929
NM_001167930
NM_001167931
NM_002182
NM_134470
IL1RAP





interleukin 1 receptor accessory protein





chr12_+_132312917 8.230 NM_016155
MMP17
matrix metallopeptidase 17 (membrane-inserted)
chr5_+_133450353 8.198 NM_003202
TCF7
transcription factor 7 (T-cell specific, HMG-box)
chr8_-_82024277 8.049 NM_018440
PAG1
phosphoprotein associated with glycosphingolipid microdomains 1
chr18_+_11689135 7.915 NM_182978
GNAL
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
chr12_-_89745997 7.755 DUSP6
dual specificity phosphatase 6
chrX_+_102632108 7.535 NM_014380
NGFRAP1
nerve growth factor receptor (TNFRSF16) associated protein 1
chrX_-_48693934 7.534 NM_013271
PCSK1N
proprotein convertase subtilisin/kexin type 1 inhibitor
chr7_+_29846112 7.527 NM_001080529
WIPF3
WAS/WASL interacting protein family, member 3
chr3_+_186648515 7.426 ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr16_+_56703725 7.264 NM_005951
MT1H
metallothionein 1H
chr20_+_45523247 7.246 NM_005244
NM_172110
EYA2

eyes absent homolog 2 (Drosophila)

chr7_+_102074002 7.219 ORAI2
ORAI calcium release-activated calcium modulator 2
chr8_-_121824268 7.050 SNTB1
syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
chr12_-_45270071 7.037 NELL2
NEL-like 2 (chicken)
chr5_+_52776263 6.912 NM_006350
NM_013409
FST

follistatin

chr17_+_7452374 6.883 NM_172089
NM_003809
TNFSF12-TNFSF13
TNFSF12
TNFSF12-TNFSF13 readthrough
tumor necrosis factor (ligand) superfamily, member 12
chr19_-_18717467 6.812 CRLF1
cytokine receptor-like factor 1
chr16_+_84853585 6.778 NM_031476
CRISPLD2
cysteine-rich secretory protein LCCL domain containing 2
chr17_-_78450247 6.771 NM_002522
NPTX1
neuronal pentraxin I
chr20_+_45523523 6.684 EYA2
eyes absent homolog 2 (Drosophila)
chr3_-_13921617 6.639 NM_004625
WNT7A
wingless-type MMTV integration site family, member 7A
chr20_+_45523505 6.623 EYA2
eyes absent homolog 2 (Drosophila)
chr2_-_160761192 6.496 LY75-CD302
LY75
LY75-CD302 readthrough
lymphocyte antigen 75
chr19_-_51522953 6.418 NM_145888
KLK10
kallikrein-related peptidase 10
chr19_-_18717631 6.417 NM_004750
CRLF1
cytokine receptor-like factor 1
chr16_-_56701904 6.393 NM_005950
MT1G
metallothionein 1G
chr22_-_20792047 6.392 SCARF2
scavenger receptor class F, member 2
chr3_-_52090090 6.357 NM_001947
DUSP7
dual specificity phosphatase 7
chr7_+_121513210 6.340 PTPRZ1
protein tyrosine phosphatase, receptor-type, Z polypeptide 1
chr2_-_233792825 6.276 NM_001114090
NGEF
neuronal guanine nucleotide exchange factor
chr17_+_60704747 6.150 NM_006039
MRC2
mannose receptor, C type 2
chr2_+_113403433 6.097 NM_005415
SLC20A1
solute carrier family 20 (phosphate transporter), member 1
chr20_-_56284945 6.095 NM_020182
PMEPA1
prostate transmembrane protein, androgen induced 1
chr6_-_89827605 6.054 NM_080743
SRSF12
serine/arginine-rich splicing factor 12
chr20_-_46414636 5.990 NM_018837
SULF2
sulfatase 2
chr14_+_105941061 5.985 NM_001312
CRIP2
cysteine-rich protein 2
chr7_+_89840999 5.968 NM_001244944
NM_001244945
NM_152999
NM_001040665
NM_001244946
STEAP2




STEAP family member 2, metalloreductase




chr17_+_29248697 5.964 NM_018404
ADAP2
ArfGAP with dual PH domains 2
chr18_+_10454620 5.901 NM_153000
APCDD1
adenomatosis polyposis coli down-regulated 1
chr10_-_44144266 5.844 NM_006973
ZNF32
zinc finger protein 32
chrX_-_153095996 5.834 NM_032512
PDZD4
PDZ domain containing 4
chr5_+_156887204 5.824 NIPAL4
NIPA-like domain containing 4
chr11_+_65779461 5.743 NM_001323
CST6
cystatin E/M
chr2_-_235405692 5.727 NM_005737
ARL4C
ADP-ribosylation factor-like 4C
chr1_-_115632047 5.724 NM_005725
TSPAN2
tetraspanin 2
chr1_+_210406194 5.717 NM_019605
SERTAD4
SERTA domain containing 4
chr11_-_125366048 5.668 NM_005103
NM_022549
FEZ1

fasciculation and elongation protein zeta 1 (zygin I)

chr3_-_45267804 5.646 NM_015444
TMEM158
transmembrane protein 158 (gene/pseudogene)
chr12_-_45270632 5.617 NM_001145107
NELL2
NEL-like 2 (chicken)
chr15_-_101084871 5.615 NM_178842
CERS3
ceramide synthase 3
chr7_+_1126442 5.585 NM_001039966
NM_001505
GPER

G protein-coupled estrogen receptor 1

chr17_+_74380943 5.577 SPHK1
sphingosine kinase 1
chr22_-_20792107 5.548 NM_153334
NM_182895
SCARF2

scavenger receptor class F, member 2

chr9_+_33750463 5.546 NM_001197097
NM_007343
NM_001197098
PRSS3


protease, serine, 3


chrX_+_102631267 5.500 NM_206915
NM_206917
NGFRAP1

nerve growth factor receptor (TNFRSF16) associated protein 1

chr8_+_121823538 5.460


chr16_+_56666533 5.407 NM_176870
MT1M
metallothionein 1M
chr15_+_68871285 5.403 NM_006091
CORO2B
coronin, actin binding protein, 2B
chr16_+_82660573 5.375 CDH13
cadherin 13, H-cadherin (heart)
chr15_+_32933869 5.350 NM_001144757
NM_003020
SCG5

secretogranin V (7B2 protein)

chr12_-_45269953 5.347 NELL2
NEL-like 2 (chicken)
chr5_-_138730884 5.331 NM_001161546
C5orf65
chromosome 5 open reading frame 65
chr12_-_93964636 5.308


chr16_+_69139466 5.267 NM_001199280
HAS3
hyaluronan synthase 3
chr16_+_1203240 5.265 NM_001005407
NM_021098
CACNA1H

calcium channel, voltage-dependent, T type, alpha 1H subunit

chr20_-_62130390 5.221 NM_001958
EEF1A2
eukaryotic translation elongation factor 1 alpha 2
chr2_-_96810775 5.157 DUSP2
dual specificity phosphatase 2
chr8_-_121824015 5.139


chrX_-_17879355 5.033 NM_001172732
NM_001172739
NM_001172743
NM_021785
RAI2



retinoic acid induced 2



chr16_+_84002099 5.021 NM_019065
NECAB2
N-terminal EF-hand calcium binding protein 2
chr2_+_10091791 5.019 NM_198182
GRHL1
grainyhead-like 1 (Drosophila)
chr18_+_43913906 5.014 RNF165
ring finger protein 165
chr7_-_139168408 5.012 NM_198508
KLRG2
killer cell lectin-like receptor subfamily G, member 2
chr2_+_30454396 4.979 NM_030915
LBH
limb bud and heart development homolog (mouse)
chr22_+_38035683 4.969 NM_018957
SH3BP1
SH3-domain binding protein 1
chr11_+_94277005 4.935 NM_002033
PIWIL4
FUT4
piwi-like 4 (Drosophila)
fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
chr22_+_29279573 4.921 NM_001206998
ZNRF3
zinc and ring finger 3
chr22_+_38035718 4.920 SH3BP1
SH3-domain binding protein 1
chr6_-_110679474 4.908 NM_001123364
C6orf186
chromosome 6 open reading frame 186
chr19_-_51523272 4.876 NM_002776
NM_001077500
KLK10

kallikrein-related peptidase 10

chr15_+_73976537 4.827


chr15_+_25200069 4.808 NM_003097
NM_022804
NM_005678
SNRPN
SNURF

small nuclear ribonucleoprotein polypeptide N
SNRPN upstream reading frame

chr10_-_92617417 4.803 HTR7
5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)
chr11_+_1411089 4.781 NM_003957
BRSK2
BR serine/threonine kinase 2
chr15_+_69591272 4.773 NM_017705
PAQR5
progestin and adipoQ receptor family member V
chrX_+_68725077 4.761 NM_015686
FAM155B
family with sequence similarity 155, member B
chr16_+_82660641 4.733 CDH13
cadherin 13, H-cadherin (heart)
chr20_-_4804067 4.719 NM_014737
RASSF2
Ras association (RalGDS/AF-6) domain family member 2
chr1_-_6321034 4.677 NM_207370
GPR153
G protein-coupled receptor 153
chr11_-_75062650 4.670 NM_004041
NM_020251
ARRB1

arrestin, beta 1

chr11_+_35639734 4.640 NM_014344
FJX1
four jointed box 1 (Drosophila)
chr19_+_21579884 4.608 NM_001076678
NM_145326
NM_175910
ZNF493


zinc finger protein 493


chr3_-_16555128 4.604 NM_015150
RFTN1
raftlin, lipid raft linker 1
chr2_+_241375207 4.590 GPC1
glypican 1
chr8_-_145515014 4.586 BOP1
block of proliferation 1
chr17_-_46655544 4.582 NM_024015
HOXB4
homeobox B4
chr2_+_132285469 4.567 NM_138770
CCDC74A
coiled-coil domain containing 74A
chr22_+_38201232 4.557 H1F0
H1 histone family, member 0
chr10_-_92617670 4.556 NM_000872
NM_019859
NM_019860
HTR7


5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)


chr9_+_17578952 4.545 NM_003026
SH3GL2
SH3-domain GRB2-like 2
chr8_+_1712011 4.536 CLN8
ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
chr1_+_15250578 4.525 NM_001018000
KAZN
kazrin, periplakin interacting protein
chr7_+_73082320 4.516 VPS37D
vacuolar protein sorting 37 homolog D (S. cerevisiae)
chr2_-_96811138 4.510 NM_004418
DUSP2
dual specificity phosphatase 2
chr3_-_53880403 4.482 NM_018397
CHDH
choline dehydrogenase
chr3_-_183543295 4.477 NM_024871
MAP6D1
MAP6 domain containing 1
chr4_+_42399855 4.458 NM_001080505
SHISA3
shisa homolog 3 (Xenopus laevis)
chr3_-_38691118 4.451 NM_000335
NM_001099404
NM_001099405
NM_198056
NM_001160160
NM_001160161
SCN5A





sodium channel, voltage-gated, type V, alpha subunit





chr18_-_5543967 4.442 NM_012307
EPB41L3
erythrocyte membrane protein band 4.1-like 3
chr9_+_140772228 4.426 NM_000718
NM_001243812
CACNA1B

calcium channel, voltage-dependent, N type, alpha 1B subunit

chr15_-_26108236 4.414 NM_024490
ATP10A
ATPase, class V, type 10A
chr7_+_29234325 4.404 CHN2
chimerin (chimaerin) 2
chr1_-_85358851 4.392 NM_012152
LPAR3
lysophosphatidic acid receptor 3
chr12_-_133464197 4.381 NM_001161344
NM_001161345
NM_001161346
NM_001161347
NM_018223
CHFR




checkpoint with forkhead and ring finger domains




chrX_+_152760346 4.381 NM_001711
BGN
biglycan
chr14_-_99737554 4.363 BCL11B
B-cell CLL/lymphoma 11B (zinc finger protein)
chr2_-_110873353 4.362 MALL
mal, T-cell differentiation protein-like
chr22_+_38201113 4.335 NM_005318
H1F0
H1 histone family, member 0
chr6_+_160148485 4.333 WTAP
Wilms tumor 1 associated protein
chr16_+_27325244 4.319 NM_000418
NM_001008699
IL4R

interleukin 4 receptor

chr8_+_146277789 4.310 NM_023080
C8orf33
chromosome 8 open reading frame 33
chr12_-_76425375 4.308 NM_007350
PHLDA1
pleckstrin homology-like domain, family A, member 1
chr5_+_176873795 4.289 NM_001174101
NM_030567
PRR7

proline rich 7 (synaptic)

chrX_-_43741593 4.285 NM_000898
MAOB
monoamine oxidase B
chr1_+_226250413 4.278 H3F3A
H3 histone, family 3A
chr16_+_1203737 4.267 CACNA1H
calcium channel, voltage-dependent, T type, alpha 1H subunit
chr13_-_77460432 4.254 NM_138444
KCTD12
potassium channel tetramerisation domain containing 12
chr12_-_89746244 4.247 NM_001946
NM_022652
DUSP6

dual specificity phosphatase 6

chr16_+_27325269 4.239 IL4R
interleukin 4 receptor
chr15_+_80696569 4.233 NM_014862
ARNT2
aryl-hydrocarbon receptor nuclear translocator 2
chr21_-_43299407 4.232 NM_001040424
NM_022115
PRDM15

PR domain containing 15

chr3_-_185542744 4.228 IGF2BP2
insulin-like growth factor 2 mRNA binding protein 2
chr12_-_89745753 4.226 DUSP6
dual specificity phosphatase 6
chr2_-_100721128 4.215 AFF3
AF4/FMR2 family, member 3
chr17_-_27949814 4.188 CORO6
coronin 6
chr9_-_38069082 4.180 SHB
Src homology 2 domain containing adaptor protein B
chr18_+_77155966 4.170 NFATC1
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
chr13_-_80915041 4.153 NM_005842
SPRY2
sprouty homolog 2 (Drosophila)
chr11_+_125774271 4.149 NM_013264
DDX25
DEAD (Asp-Glu-Ala-Asp) box polypeptide 25
chr20_-_10654139 4.128 JAG1
jagged 1
chr16_+_56716378 4.123 NM_005952
MT1X
metallothionein 1X
chr13_-_77460369 4.118 KCTD12
potassium channel tetramerisation domain containing 12
chr19_-_18717577 4.117 CRLF1
cytokine receptor-like factor 1
chr20_-_55841671 4.112 NM_001719
BMP7
bone morphogenetic protein 7
chr14_+_65007418 4.100 HSPA2
heat shock 70kDa protein 2
chr16_+_69141442 4.078 NM_005329
HAS3
hyaluronan synthase 3
chr9_-_113800243 4.068 NM_001401
NM_057159
LPAR1

lysophosphatidic acid receptor 1

chrX_-_8700170 4.053 NM_000216
KAL1
Kallmann syndrome 1 sequence
chr16_-_89007605 4.052 NM_175931
CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr19_-_12251092 4.042 NM_001203250
NM_021143
ZNF20

zinc finger protein 20

chr7_+_102073953 4.037 NM_001126340
NM_032831
ORAI2

ORAI calcium release-activated calcium modulator 2

chrX_-_64254592 4.025 NM_001178032
NM_001243804
ZC4H2

zinc finger, C4H2 domain containing

chr18_+_77155927 4.003 NFATC1
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
chr3_-_45267620 3.967 TMEM158
transmembrane protein 158 (gene/pseudogene)
chr6_-_170600165 3.962


chr1_+_9648931 3.959 NM_001010866
NM_001130924
TMEM201

transmembrane protein 201

chr10_+_12391728 3.937 CAMK1D
calcium/calmodulin-dependent protein kinase ID
chr1_-_200992824 3.936 NM_001252100
NM_001252102
NM_001252103
NM_017596
KIF21B



kinesin family member 21B



chr11_-_12030128 3.927 NM_001018057
DKK3
dickkopf 3 homolog (Xenopus laevis)
chr7_-_29186072 3.925 NM_019029
NM_031311
CPVL

carboxypeptidase, vitellogenic-like

chr1_+_154298026 3.919 ATP8B2
ATPase, class I, type 8B, member 2
chr12_-_76425207 3.915 PHLDA1
pleckstrin homology-like domain, family A, member 1
chr12_-_89746238 3.878 DUSP6
dual specificity phosphatase 6
chr20_-_32274070 3.835 E2F1
E2F transcription factor 1
chr1_+_154298034 3.818 NM_001005855
ATP8B2
ATPase, class I, type 8B, member 2
chr9_-_113800980 3.805 LPAR1
lysophosphatidic acid receptor 1
chr12_-_120806893 3.796 NM_002442
MSI1
musashi homolog 1 (Drosophila)
chr19_+_589849 3.796 NM_001194
HCN2
hyperpolarization activated cyclic nucleotide-gated potassium channel 2
chr1_-_62785067 3.782 NM_181712
KANK4
KN motif and ankyrin repeat domains 4
chr19_-_51512803 3.755 NM_012315
KLK9
kallikrein-related peptidase 9
chr2_-_204399906 3.747 NM_203365
NM_213589
RAPH1

Ras association (RalGDS/AF-6) and pleckstrin homology domains 1

chr11_-_67141008 3.735 NM_013246
CLCF1
cardiotrophin-like cytokine factor 1
chr3_+_36421944 3.730 NM_003149
STAC
SH3 and cysteine rich domain
chr17_-_80656461 3.715 NM_006822
RAB40B
RAB40B, member RAS oncogene family

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
2.03 5.20e-23 GO:0030154 cell differentiation
1.98 9.72e-22 GO:0048869 cellular developmental process
2.22 1.31e-21 GO:0007399 nervous system development
1.65 1.34e-20 GO:0032502 developmental process
1.69 2.03e-20 GO:0007275 multicellular organismal development
1.77 1.24e-19 GO:0048731 system development
1.71 2.48e-19 GO:0048856 anatomical structure development
2.47 8.73e-18 GO:0022008 neurogenesis
2.49 4.32e-17 GO:0048699 generation of neurons
2.57 7.93e-15 GO:0030182 neuron differentiation
1.43 1.55e-14 GO:0032501 multicellular organismal process
1.96 1.30e-13 GO:0009653 anatomical structure morphogenesis
1.53 2.33e-13 GO:0023052 signaling
2.00 2.77e-12 GO:0051239 regulation of multicellular organismal process
2.54 2.38e-11 GO:0048666 neuron development
2.77 6.08e-11 GO:0048667 cell morphogenesis involved in neuron differentiation
2.62 1.14e-10 GO:0000904 cell morphogenesis involved in differentiation
2.72 1.44e-10 GO:0048812 neuron projection morphogenesis
2.61 2.00e-10 GO:0031175 neuron projection development
1.27 2.30e-10 GO:0065007 biological regulation
2.11 4.99e-10 GO:0050793 regulation of developmental process
2.70 1.23e-09 GO:0007409 axonogenesis
2.05 4.89e-09 GO:0048468 cell development
2.46 1.25e-08 GO:0048858 cell projection morphogenesis
2.26 1.81e-08 GO:0030030 cell projection organization
2.44 1.88e-08 GO:0032990 cell part morphogenesis
2.43 2.08e-08 GO:0007417 central nervous system development
2.12 5.66e-08 GO:2000026 regulation of multicellular organismal development
2.18 6.62e-08 GO:0045595 regulation of cell differentiation
2.09 1.05e-07 GO:0007267 cell-cell signaling
2.39 1.26e-07 GO:0019226 transmission of nerve impulse
2.39 1.26e-07 GO:0035637 multicellular organismal signaling
1.92 1.29e-07 GO:0007154 cell communication
2.23 2.12e-07 GO:0000902 cell morphogenesis
1.26 3.28e-07 GO:0050794 regulation of cellular process
1.43 4.11e-07 GO:0007165 signal transduction
2.44 4.69e-07 GO:0007268 synaptic transmission
1.67 5.54e-07 GO:0023051 regulation of signaling
1.24 7.04e-07 GO:0050789 regulation of biological process
1.61 8.87e-07 GO:0048513 organ development
2.15 9.54e-07 GO:0032989 cellular component morphogenesis
2.52 2.63e-06 GO:0007420 brain development
2.58 3.68e-06 GO:0007411 axon guidance
1.66 1.57e-05 GO:0009966 regulation of signal transduction
1.78 1.77e-05 GO:0010646 regulation of cell communication
1.57 1.92e-05 GO:0007166 cell surface receptor linked signaling pathway
1.13 4.02e-05 GO:0009987 cellular process
1.46 1.15e-04 GO:0048519 negative regulation of biological process
1.47 1.36e-04 GO:0042221 response to chemical stimulus
3.00 1.50e-04 GO:0030900 forebrain development
1.48 1.57e-04 GO:0048523 negative regulation of cellular process
1.32 1.66e-04 GO:0051716 cellular response to stimulus
2.28 1.99e-04 GO:0060429 epithelium development
2.17 2.29e-04 GO:0023057 negative regulation of signaling
2.14 3.72e-04 GO:0051094 positive regulation of developmental process
2.07 4.05e-04 GO:0048585 negative regulation of response to stimulus
1.50 4.46e-04 GO:0048583 regulation of response to stimulus
2.12 6.04e-04 GO:0010648 negative regulation of cell communication
2.16 7.86e-04 GO:0009968 negative regulation of signal transduction
2.51 1.18e-03 GO:0050767 regulation of neurogenesis
1.85 1.29e-03 GO:0009790 embryo development
2.30 1.40e-03 GO:0060284 regulation of cell development
2.38 1.48e-03 GO:0007423 sensory organ development
2.36 2.75e-03 GO:0035295 tube development
2.36 2.75e-03 GO:0051960 regulation of nervous system development
1.21 2.81e-03 GO:0050896 response to stimulus
1.72 3.13e-03 GO:0009888 tissue development
2.60 3.51e-03 GO:0007548 sex differentiation
2.20 4.76e-03 GO:0045597 positive regulation of cell differentiation
1.54 5.09e-03 GO:0035556 intracellular signal transduction
1.97 5.23e-03 GO:0030001 metal ion transport
1.86 6.00e-03 GO:0009887 organ morphogenesis
1.74 8.79e-03 GO:0007155 cell adhesion
1.74 8.79e-03 GO:0022610 biological adhesion
2.97 9.73e-03 GO:0001763 morphogenesis of a branching structure
1.91 1.02e-02 GO:0006935 chemotaxis
1.91 1.02e-02 GO:0042330 taxis
1.63 1.06e-02 GO:0009605 response to external stimulus
2.95 1.12e-02 GO:0030799 regulation of cyclic nucleotide metabolic process
4.12 1.13e-02 GO:0034765 regulation of ion transmembrane transport
3.37 1.16e-02 GO:0001505 regulation of neurotransmitter levels
2.55 1.81e-02 GO:0030855 epithelial cell differentiation
4.20 1.95e-02 GO:0032412 regulation of ion transmembrane transporter activity
3.13 2.00e-02 GO:0051924 regulation of calcium ion transport
3.03 2.02e-02 GO:0043583 ear development
1.64 2.05e-02 GO:0006811 ion transport
2.91 2.28e-02 GO:0010959 regulation of metal ion transport
2.89 2.60e-02 GO:0030802 regulation of cyclic nucleotide biosynthetic process
2.89 2.60e-02 GO:0030808 regulation of nucleotide biosynthetic process
2.14 2.66e-02 GO:0022603 regulation of anatomical structure morphogenesis
2.97 2.68e-02 GO:0030817 regulation of cAMP biosynthetic process
6.60 2.94e-02 GO:0060425 lung morphogenesis
2.08 3.02e-02 GO:0044057 regulation of system process
3.16 3.07e-02 GO:0030278 regulation of ossification
2.95 3.08e-02 GO:0030814 regulation of cAMP metabolic process
4.05 3.08e-02 GO:0022898 regulation of transmembrane transporter activity
1.60 3.33e-02 GO:0042127 regulation of cell proliferation
1.80 3.36e-02 GO:0006812 cation transport
3.13 3.57e-02 GO:0048754 branching morphogenesis of a tube
2.75 3.62e-02 GO:0072511 divalent inorganic cation transport
2.22 3.65e-02 GO:0045596 negative regulation of cell differentiation
3.72 4.01e-02 GO:0032409 regulation of transporter activity
2.31 4.05e-02 GO:0002009 morphogenesis of an epithelium
3.09 4.15e-02 GO:0045761 regulation of adenylate cyclase activity
2.53 4.33e-02 GO:0045137 development of primary sexual characteristics
1.51 4.43e-02 GO:0010033 response to organic substance

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.67 1.01e-11 GO:0044459 plasma membrane part
1.35 5.95e-07 GO:0005886 plasma membrane
1.34 1.27e-06 GO:0071944 cell periphery
2.24 3.29e-05 GO:0031012 extracellular matrix
1.69 6.02e-05 GO:0044421 extracellular region part
2.32 7.50e-05 GO:0005578 proteinaceous extracellular matrix
2.13 1.23e-04 GO:0045202 synapse
3.05 1.62e-04 GO:0034703 cation channel complex
2.07 4.71e-04 GO:0043005 neuron projection
7.07 5.11e-04 GO:0005891 voltage-gated calcium channel complex
1.55 6.90e-04 GO:0031226 intrinsic to plasma membrane
1.67 8.44e-04 GO:0042995 cell projection
5.69 1.41e-03 GO:0034704 calcium channel complex
1.54 1.41e-03 GO:0005887 integral to plasma membrane
1.15 6.23e-03 GO:0016020 membrane
2.30 7.69e-03 GO:0034702 ion channel complex
1.90 1.64e-02 GO:0009986 cell surface
13.19 1.98e-02 GO:0001931 uropod
13.19 1.98e-02 GO:0031254 trailing edge
2.01 2.26e-02 GO:0044456 synapse part
3.09 2.56e-02 GO:0009898 internal side of plasma membrane

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
1.85 2.06e-04 GO:0043565 sequence-specific DNA binding
3.02 2.25e-04 GO:0022843 voltage-gated cation channel activity
2.37 3.77e-04 GO:0005261 cation channel activity
6.34 8.21e-04 GO:0005245 voltage-gated calcium channel activity
2.19 1.53e-03 GO:0022836 gated channel activity
2.56 1.75e-03 GO:0005244 voltage-gated ion channel activity
2.56 1.75e-03 GO:0022832 voltage-gated channel activity
1.85 1.99e-03 GO:0008324 cation transmembrane transporter activity
1.98 2.95e-03 GO:0022803 passive transmembrane transporter activity
1.96 5.93e-03 GO:0022838 substrate-specific channel activity
1.94 6.06e-03 GO:0015267 channel activity
1.58 6.85e-03 GO:0001071 nucleic acid binding transcription factor activity
1.58 6.85e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
3.43 7.27e-03 GO:0005262 calcium channel activity
1.95 8.68e-03 GO:0005216 ion channel activity
1.54 1.73e-02 GO:0030528 transcription regulator activity
1.64 2.04e-02 GO:0015075 ion transmembrane transporter activity
2.29 2.18e-02 GO:0000975 regulatory region DNA binding
2.29 2.18e-02 GO:0001067 regulatory region nucleic acid binding
2.29 2.18e-02 GO:0044212 transcription regulatory region DNA binding
2.30 2.77e-02 GO:0010843 promoter binding
7.61 3.36e-02 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity
1.56 3.59e-02 GO:0022891 substrate-specific transmembrane transporter activity