Motif ID: MSX1,2.p2

Z-value: 0.704


Transcription factors associated with MSX1,2.p2:

Gene SymbolEntrez IDGene Name
MSX1 4487 msh homeobox 1
MSX2 4488 msh homeobox 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
MSX2hg19_v1_chr5_+_174151531_1741516940.455.5e-05Click!
MSX1hg19_v1_chr4_+_4861371_4861426-0.019.4e-01Click!


Activity profile for motif MSX1,2.p2.

activity profile for motif MSX1,2.p2


Sorted Z-values histogram for motif MSX1,2.p2

Sorted Z-values for motif MSX1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MSX1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_+_115567746 5.727 NM_007231
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chrX_+_115567820 3.365 SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chrX_-_133792497 2.891 NM_021796
PLAC1
placenta-specific 1
chr1_+_153190059 2.752 NM_001195571
PRR9
proline rich 9
chr1_+_153330329 2.572 NM_002965
S100A9
S100 calcium binding protein A9
chr21_-_37852387 2.468 NM_001146079
NM_144492
CLDN14

claudin 14

chr11_+_15133969 2.238 NM_001031853
INSC
inscuteable homolog (Drosophila)
chr17_-_78450247 2.220 NM_002522
NPTX1
neuronal pentraxin I
chr1_+_204839977 2.202 NFASC
neurofascin
chr8_+_75736771 2.183 NM_015886
PI15
peptidase inhibitor 15
chr5_+_59784004 2.158 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr11_-_85397215 2.073 NM_152723
CCDC89
coiled-coil domain containing 89
chr17_-_38859976 2.073 NM_019016
KRT24
keratin 24
chr5_-_90610218 2.065 LOC100505994
uncharacterized LOC100505994
chr9_-_116840551 2.000 AMBP
alpha-1-microglobulin/bikunin precursor
chr1_-_152061529 1.921 NM_001008536
TCHHL1
trichohyalin-like 1
chr19_-_7698569 1.905 NM_174895
PCP2
Purkinje cell protein 2
chr3_+_100238063 1.883 TMEM45A
transmembrane protein 45A
chr2_-_238322815 1.847 COL6A3
collagen, type VI, alpha 3
chr14_-_94254765 1.841 NM_178013
PRIMA1
proline rich membrane anchor 1
chr8_-_38008332 1.820 NM_000349
STAR
steroidogenic acute regulatory protein
chr3_+_25470067 1.807 RARB
retinoic acid receptor, beta
chr1_-_108231122 1.804 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr7_-_14025826 1.783 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr2_-_238322814 1.730 COL6A3
collagen, type VI, alpha 3
chr10_-_50599906 1.632 NM_001080520
DRGX
dorsal root ganglia homeobox
chr2_-_238322806 1.608 COL6A3
collagen, type VI, alpha 3
chr9_+_136501484 1.593 NM_000787
DBH
dopamine beta-hydroxylase (dopamine beta-monooxygenase)
chr20_+_123230 1.585 NM_030931
DEFB126
defensin, beta 126
chr6_+_16129285 1.570 NM_013262
MYLIP
myosin regulatory light chain interacting protein
chr21_+_31802571 1.565 NM_181600
KRTAP13-4
keratin associated protein 13-4
chr11_+_7618416 1.540 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr9_-_116840460 1.530 AMBP
alpha-1-microglobulin/bikunin precursor
chr5_-_160279045 1.504 NM_025153
ATP10B
ATPase, class V, type 10B
chr2_-_238322840 1.472 NM_004369
NM_057164
NM_057165
NM_057166
NM_057167
COL6A3




collagen, type VI, alpha 3




chr2_-_238322770 1.437 COL6A3
collagen, type VI, alpha 3
chr10_+_7745354 1.436 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr21_+_43619798 1.365 NM_207627
NM_207628
ABCG1

ATP-binding cassette, sub-family G (WHITE), member 1

chr17_-_66951381 1.360 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr12_+_71833518 1.358 LGR5
leucine-rich repeat containing G protein-coupled receptor 5
chr16_+_66400559 1.338 CDH5
cadherin 5, type 2 (vascular endothelium)
chrX_-_11284094 1.306 NM_013423
ARHGAP6
Rho GTPase activating protein 6
chr2_-_77749335 1.290 NM_001134745
NM_024993
LRRTM4

leucine rich repeat transmembrane neuronal 4

chr6_-_51952368 1.249 NM_138694
NM_170724
PKHD1

polycystic kidney and hepatic disease 1 (autosomal recessive)

chr11_-_6790187 1.246 NM_001004490
OR2AG2
olfactory receptor, family 2, subfamily AG, member 2
chr10_+_7745325 1.204 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr9_-_116840604 1.187 AMBP
alpha-1-microglobulin/bikunin precursor
chr17_+_68071386 1.145 NM_018658
NM_170741
KCNJ16

potassium inwardly-rectifying channel, subfamily J, member 16

chr4_+_155484131 1.114 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr19_-_17375522 1.106 NM_031941
USHBP1
Usher syndrome 1C binding protein 1
chr12_+_53818864 1.076 AMHR2
anti-Mullerian hormone receptor, type II
chr3_-_165555252 1.074 NM_000055
BCHE
butyrylcholinesterase
chr11_-_83393436 1.045 NM_001142702
DLG2
discs, large homolog 2 (Drosophila)
chr12_+_54892567 1.019 NM_001184976
NCKAP1L
NCK-associated protein 1-like
chr6_+_50786438 1.002 NM_003221
TFAP2B
transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
chr4_+_15429628 0.984 NM_031911
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr6_-_154677868 0.968 NM_001130700
NM_015553
IPCEF1

interaction protein for cytohesin exchange factors 1

chr17_-_9929567 0.952 NM_001130831
GAS7
growth arrest-specific 7
chr4_+_88896838 0.946 SPP1
secreted phosphoprotein 1
chr17_-_33885106 0.943 NM_001129820
SLFN14
schlafen family member 14
chr4_+_71296208 0.937 NM_001145006
MUC7
mucin 7, secreted
chr3_-_165555167 0.936 BCHE
butyrylcholinesterase
chr4_+_88896801 0.935 NM_000582
NM_001040058
NM_001040060
NM_001251829
NM_001251830
SPP1




secreted phosphoprotein 1




chr12_-_113574020 0.932 NM_001193520
NM_004658
RASAL1

RAS protein activator like 1 (GAP1 like)

chr8_-_27115935 0.926 STMN4
stathmin-like 4
chr8_+_24298442 0.919 NM_003817
ADAM7
ADAM metallopeptidase domain 7
chr1_-_154832187 0.873 NM_170782
KCNN3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr9_+_120466607 0.869 TLR4
toll-like receptor 4
chr3_+_52828783 0.851 NM_002217
ITIH3
inter-alpha-trypsin inhibitor heavy chain 3
chr4_+_71062241 0.836 NM_017855
ODAM
odontogenic, ameloblast asssociated
chr9_+_1050367 0.833 DMRT2
doublesex and mab-3 related transcription factor 2
chr2_+_113825546 0.827 NM_173161
IL1F10
interleukin 1 family, member 10 (theta)
chr4_+_88896899 0.826 SPP1
secreted phosphoprotein 1
chr3_-_151102536 0.823 NM_022788
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr12_+_54891522 0.823 NCKAP1L
NCK-associated protein 1-like
chr4_-_189026401 0.821 NM_173553
TRIML2
tripartite motif family-like 2
chr21_-_19775958 0.815 NM_002772
TMPRSS15
transmembrane protease, serine 15
chr9_-_116840545 0.804 AMBP
alpha-1-microglobulin/bikunin precursor
chr2_+_219745243 0.787 NM_025216
WNT10A
wingless-type MMTV integration site family, member 10A
chr5_-_138210992 0.777 CTNNA1
LRRTM2
catenin (cadherin-associated protein), alpha 1, 102kDa
leucine rich repeat transmembrane neuronal 2
chr21_-_31538970 0.776 NM_012131
CLDN17
claudin 17
chr8_-_30706532 0.773 NM_031271
TEX15
testis expressed 15
chr9_+_1050333 0.767 NM_006557
NM_001130865
DMRT2

doublesex and mab-3 related transcription factor 2

chr4_+_88896868 0.763 SPP1
secreted phosphoprotein 1
chrY_+_1337692 0.762 NM_001161529
NM_001161531
NM_001161532
NM_006140
NM_172245
NM_172246
NM_172249
CSF2RA






colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)






chr14_+_78870092 0.749 NM_004796
NRXN3
neurexin 3
chr19_-_17958773 0.745 JAK3
Janus kinase 3
chrX_+_66788682 0.744 NM_001011645
AR
androgen receptor
chr12_+_101188373 0.737 NM_178826
ANO4
anoctamin 4
chr12_-_71551564 0.734 TSPAN8
tetraspanin 8
chr5_-_138211054 0.731 NM_015564
LRRTM2
leucine rich repeat transmembrane neuronal 2
chr10_-_52008312 0.730 NM_001143974
NM_019893
ASAH2

N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2

chr13_-_70682458 0.729 NM_020866
KLHL1
kelch-like 1 (Drosophila)
chr7_+_114066554 0.718 NM_001172767
NM_148899
FOXP2

forkhead box P2

chr13_-_99910548 0.718 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chr12_+_54891491 0.710 NM_005337
NCKAP1L
NCK-associated protein 1-like
chr4_-_41884568 0.702


chr2_+_171034654 0.699 NM_001083615
NM_001171642
NM_138995
MYO3B


myosin IIIB


chr6_+_12514300 0.684


chr1_-_203154304 0.674 CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chr3_+_46616044 0.672 NM_001174136
TDGF1
teratocarcinoma-derived growth factor 1
chr6_-_32977312 0.669 HLA-DOA
major histocompatibility complex, class II, DO alpha
chr6_-_28483563 0.666 NM_182701
GPX6
glutathione peroxidase 6 (olfactory)
chr6_+_16129321 0.664 MYLIP
myosin regulatory light chain interacting protein
chr12_+_54891539 0.661 NCKAP1L
NCK-associated protein 1-like
chr7_+_39017608 0.655 NM_001166018
NM_007252
POU6F2

POU class 6 homeobox 2

chr10_+_115511212 0.650 NM_001193434
NM_001193435
NM_024889
C10orf81


chromosome 10 open reading frame 81


chr5_-_148758787 0.638 NM_014443
IL17B
interleukin 17B
chr11_-_40315663 0.638 NM_020929
LRRC4C
leucine rich repeat containing 4C
chr4_-_66536182 0.637 EPHA5
EPH receptor A5
chr6_-_32977351 0.637 NM_002119
HLA-DOA
major histocompatibility complex, class II, DO alpha
chr6_-_123957941 0.636 NM_001251987
NM_006073
TRDN

triadin

chr6_-_55740387 0.629 BMP5
bone morphogenetic protein 5
chr10_+_7745341 0.629 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr2_+_88367298 0.625 NM_198274
SMYD1
SET and MYND domain containing 1
chr4_+_71337833 0.612 NM_152291
MUC7
mucin 7, secreted
chr2_-_134326030 0.603 NM_207363
NM_207481
NCKAP5

NCK-associated protein 5

chr11_-_101000457 0.600 NM_000926
PGR
progesterone receptor
chr16_+_66400524 0.597 NM_001795
CDH5
cadherin 5, type 2 (vascular endothelium)
chr17_+_41857802 0.596 NM_001136483
C17orf105
chromosome 17 open reading frame 105
chr1_+_153232178 0.596 NM_000427
LOR
loricrin
chr9_-_116840673 0.593 NM_001633
AMBP
alpha-1-microglobulin/bikunin precursor
chr11_-_27681195 0.578 NM_001143816
NM_170735
BDNF

brain-derived neurotrophic factor

chr16_-_53405040 0.577 NM_001207030
LOC643802
u3 small nucleolar ribonucleoprotein protein MPP10-like
chr4_+_71337674 0.574 NM_001145007
MUC7
mucin 7, secreted
chr20_+_2276612 0.568 NM_003245
TGM3
transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)
chr4_-_44653657 0.568 NM_182592
YIPF7
Yip1 domain family, member 7
chr5_-_22212873 0.566 CDH12
cadherin 12, type 2 (N-cadherin 2)
chr10_+_7745284 0.563 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr22_+_35462125 0.563 NM_001008494
ISX
intestine-specific homeobox
chr6_-_24383519 0.538 NM_001195610
DCDC2
doublecortin domain containing 2
chr14_+_21756135 0.537 NM_020366
RPGRIP1
retinitis pigmentosa GTPase regulator interacting protein 1
chr7_+_120629444 0.535 NM_001105533
C7orf58
chromosome 7 open reading frame 58
chr16_-_90128591 0.527 NM_052996
PRDM7
PR domain containing 7
chr9_+_125376947 0.522 NM_012364
OR1Q1
olfactory receptor, family 1, subfamily Q, member 1
chrX_-_110655384 0.520 NM_178151
NM_001195553
NM_178152
NM_178153
DCX



doublecortin



chr2_+_169937616 0.519 NM_001142271
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr16_-_21289571 0.517 CRYM
crystallin, mu
chr6_-_39693110 0.516 NM_145027
KIF6
kinesin family member 6
chr12_-_13248581 0.515 NM_001206843
NM_001206845
NM_031289
NM_153823
GSG1



germ cell associated 1



chr17_+_67498391 0.510 MAP2K6
mitogen-activated protein kinase kinase 6
chr13_-_86373328 0.502 NM_032229
SLITRK6
SLIT and NTRK-like family, member 6
chr20_+_43835637 0.486 NM_003007
SEMG1
semenogelin I
chr12_-_16759733 0.484 NM_001243610
LMO3
LIM domain only 3 (rhombotin-like 2)
chr12_+_50344523 0.479 NM_000486
AQP2
aquaporin 2 (collecting duct)
chr19_+_50016500 0.477 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr3_-_71180061 0.474 NM_001244815
FOXP1
forkhead box P1
chr3_-_193096513 0.473 NM_198505
ATP13A5
ATPase type 13A5
chr16_+_66400585 0.468 CDH5
cadherin 5, type 2 (vascular endothelium)
chr5_+_36608430 0.460 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr7_-_115670828 0.456 NM_001018058
NM_012252
TFEC

transcription factor EC

chr3_-_187420344 0.453 NM_001004312
RTP2
receptor (chemosensory) transporter protein 2
chr12_+_51347781 0.446 NM_001109619
HIGD1C
HIG1 hypoxia inducible domain family, member 1C
chrX_+_12924738 0.442 NM_138636
TLR8
toll-like receptor 8
chr7_+_136553398 0.442 NM_001006627
NM_001006630
CHRM2

cholinergic receptor, muscarinic 2

chr1_-_201915715 0.432 NM_012134
LMOD1
leiomodin 1 (smooth muscle)
chr2_+_137748461 0.431 NM_001080427
THSD7B
thrombospondin, type I, domain containing 7B
chr14_-_65409445 0.428 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr3_-_71179736 0.424 FOXP1
forkhead box P1
chr7_+_106505696 0.421 PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr12_-_9760481 0.421 NM_002258
KLRB1
killer cell lectin-like receptor subfamily B, member 1
chr11_+_114549199 0.417 NM_182495
FAM55B
family with sequence similarity 55, member B
chr6_-_46047978 0.415 NM_001114086
CLIC5
chloride intracellular channel 5
chr2_-_21233930 0.409 APOB
apolipoprotein B (including Ag(x) antigen)
chr1_-_169703178 0.406 NM_000450
SELE
selectin E
chr16_+_2016874 0.404 NM_174903
RNF151
ring finger protein 151
chr1_+_201979747 0.399 ELF3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr4_-_69111333 0.396 NM_182502
TMPRSS11B
transmembrane protease, serine 11B
chr1_+_186798031 0.392 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr19_-_58485901 0.391 NM_152474
C19orf18
chromosome 19 open reading frame 18
chr5_-_169724817 0.389 NM_005565
LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chrX_-_19688991 0.389 NM_001184960
SH3KBP1
SH3-domain kinase binding protein 1
chr10_-_13749622 0.384 FRMD4A
FERM domain containing 4A
chr2_+_176987412 0.381 NM_014213
HOXD9
homeobox D9
chr12_+_80838125 0.379 NM_001145026
PTPRQ
protein tyrosine phosphatase, receptor type, Q
chr11_-_59383616 0.376 NM_002556
OSBP
oxysterol binding protein
chr8_-_93075190 0.374 NM_004349
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr11_-_6913730 0.372 NM_003700
OR2D2
olfactory receptor, family 2, subfamily D, member 2
chr12_-_21487831 0.371 NM_021094
SLCO1A2
solute carrier organic anion transporter family, member 1A2
chr3_+_9944511 0.370 NM_001193380
NM_153480
IL17RE

interleukin 17 receptor E

chr15_+_99645152 0.367 NM_015286
NM_145728
SYNM

synemin, intermediate filament protein

chr20_-_49253425 0.362 NM_080829
FAM65C
family with sequence similarity 65, member C
chrX_+_28605558 0.361 NM_014271
IL1RAPL1
interleukin 1 receptor accessory protein-like 1
chr3_+_118892363 0.359 NM_006952
UPK1B
uroplakin 1B
chr11_+_1889902 0.358 NM_001013253
LSP1
lymphocyte-specific protein 1
chr6_-_49754899 0.355 NM_138733
PGK2
phosphoglycerate kinase 2
chr9_+_75136716 0.350 NM_138691
TMC1
transmembrane channel-like 1
chr17_+_74868728 0.345 NM_198955
MGAT5B
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B
chr11_+_92085261 0.343 NM_001008781
FAT3
FAT tumor suppressor homolog 3 (Drosophila)
chr7_+_80231503 0.343 NM_001001547
CD36
CD36 molecule (thrombospondin receptor)
chr3_-_71179715 0.329 FOXP1
forkhead box P1
chr2_-_21228189 0.327 APOB
apolipoprotein B (including Ag(x) antigen)
chr8_-_102803178 0.325 NCALD
neurocalcin delta
chr21_-_34185943 0.323 NM_001162495
NM_001162496
NM_019596
C21orf62


chromosome 21 open reading frame 62


chr8_+_32504250 0.321 NM_013959
NRG1
neuregulin 1
chr7_-_115670811 0.320 TFEC
transcription factor EC
chr12_+_107078476 0.320 NM_032491
RFX4
regulatory factor X, 4 (influences HLA class II expression)
chr10_+_94833646 0.314 NM_000783
CYP26A1
cytochrome P450, family 26, subfamily A, polypeptide 1
chr4_+_106473776 0.314 NM_001242729
NM_017700
ARHGEF38

Rho guanine nucleotide exchange factor (GEF) 38

chr14_-_50474237 0.312 NM_001012706
C14orf182
chromosome 14 open reading frame 182

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.