Motif ID: LMO2.p2

Z-value: 1.372


Transcription factors associated with LMO2.p2:

Gene SymbolEntrez IDGene Name
LMO2 4005 LIM domain only 2 (rhombotin-like 1)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
LMO2hg19_v1_chr11_-_33891361_33891422-0.056.6e-01Click!


Activity profile for motif LMO2.p2.

activity profile for motif LMO2.p2


Sorted Z-values histogram for motif LMO2.p2

Sorted Z-values for motif LMO2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of LMO2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_37650996 13.907 NM_014907
FRMPD1
FERM and PDZ domain containing 1
chr1_-_40367539 10.106 NM_001033081
NM_001033082
NM_005376
MYCL1


v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)


chr1_-_22469414 8.084 NM_030761
WNT4
wingless-type MMTV integration site family, member 4
chr11_-_119234628 7.617 USP2
ubiquitin specific peptidase 2
chr9_-_97401588 7.588 FBP1
fructose-1,6-bisphosphatase 1
chr4_-_149363498 7.340 NM_000901
NM_001166104
NR3C2

nuclear receptor subfamily 3, group C, member 2

chr12_-_63328663 7.168 NM_020700
PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr19_+_5904842 6.399 NM_001017921
VMAC
vimentin-type intermediate filament associated coiled-coil protein
chrX_-_107018889 6.367 TSC22D3
TSC22 domain family, member 3
chr5_-_95768660 6.282 NM_000439
PCSK1
proprotein convertase subtilisin/kexin type 1
chr9_-_97401746 6.269 FBP1
fructose-1,6-bisphosphatase 1
chr12_-_63328857 6.000 PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr1_-_45672225 5.862 NM_020883
ZSWIM5
zinc finger, SWIM-type containing 5
chr5_+_137801178 5.823 NM_001964
EGR1
early growth response 1
chr8_-_143867931 5.720 NM_003695
LY6D
lymphocyte antigen 6 complex, locus D
chr11_+_1860232 5.685 NM_003282
TNNI2
troponin I type 2 (skeletal, fast)
chr19_-_47734215 5.620 NM_014417
BBC3
BCL2 binding component 3
chr1_+_18807423 5.316 NM_152375
KLHDC7A
kelch domain containing 7A
chr17_-_46035109 5.302 NM_024320
PRR15L
proline rich 15-like
chr9_-_97401833 5.285 NM_000507
FBP1
fructose-1,6-bisphosphatase 1
chr1_-_151804225 5.204 NM_005060
RORC
RAR-related orphan receptor C
chr4_-_82393025 5.134 NM_152545
RASGEF1B
RasGEF domain family, member 1B
chr17_+_48050129 5.057 NM_001934
DLX4
distal-less homeobox 4
chr2_-_122042767 5.053 NM_014553
TFCP2L1
transcription factor CP2-like 1
chr15_-_101084871 5.040 NM_178842
CERS3
ceramide synthase 3
chr1_+_167599503 4.992 RCSD1
RCSD domain containing 1
chr22_+_24823529 4.971 NM_000675
ADORA2A
adenosine A2a receptor
chr1_-_153321021 4.908 NM_020393
PGLYRP4
peptidoglycan recognition protein 4
chr22_+_37257004 4.745 NM_000631
NM_013416
NCF4

neutrophil cytosolic factor 4, 40kDa

chr13_+_43148182 4.742 NM_003701
TNFSF11
tumor necrosis factor (ligand) superfamily, member 11
chrX_-_107019001 4.708 NM_198057
TSC22D3
TSC22 domain family, member 3
chr3_+_54156573 4.666 CACNA2D3
calcium channel, voltage-dependent, alpha 2/delta subunit 3
chr16_+_88705000 4.596 NM_013278
IL17C
interleukin 17C
chr3_+_54156691 4.456 NM_018398
CACNA2D3
calcium channel, voltage-dependent, alpha 2/delta subunit 3
chr16_+_87636492 4.452 NM_020655
JPH3
junctophilin 3
chr4_-_2420252 4.421 NM_001172656
NM_001172657
NM_001172658
NM_020972
ZFYVE28



zinc finger, FYVE domain containing 28



chr1_-_109849613 4.417 NM_001010985
MYBPHL
myosin binding protein H-like
chr11_+_129245834 4.342 NM_003658
BARX2
BARX homeobox 2
chr1_-_92951593 4.323 NM_001127216
GFI1
growth factor independent 1 transcription repressor
chr1_+_37940074 4.289 NM_025079
ZC3H12A
zinc finger CCCH-type containing 12A
chr7_+_140774031 4.200 NM_001195278
LOC100507421
transmembrane protein 178-like
chrX_-_53350521 4.148 NM_001111125
IQSEC2
IQ motif and Sec7 domain 2
chr10_-_64578926 4.138 NM_001136178
EGR2
early growth response 2
chr1_+_167599329 4.132 NM_052862
RCSD1
RCSD domain containing 1
chr7_-_95225802 4.125 NM_002612
PDK4
pyruvate dehydrogenase kinase, isozyme 4
chr4_+_7194317 4.117 NM_020777
SORCS2
sortilin-related VPS10 domain containing receptor 2
chr12_-_48398284 4.106 NM_001844
NM_033150
COL2A1

collagen, type II, alpha 1

chr1_-_23857284 4.092 E2F2
E2F transcription factor 2
chr7_+_3340919 4.061 NM_152744
SDK1
sidekick cell adhesion molecule 1
chr16_+_56225250 4.061 NM_020988
NM_138736
GNAO1

guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O

chr4_-_82392971 4.058 RASGEF1B
RasGEF domain family, member 1B
chr11_-_2018703 4.054 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr1_+_37940129 3.971 ZC3H12A
zinc finger CCCH-type containing 12A
chr2_-_7005764 3.957 NM_207315
CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr17_-_39203423 3.950 NM_001123387
KRTAP2-1
keratin associated protein 2-1
chr15_+_47476225 3.944 NM_001198999
SEMA6D
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr2_+_223289212 3.942 SGPP2
sphingosine-1-phosphate phosphatase 2
chr21_+_42688660 3.935 NM_058186
NM_206964
FAM3B

family with sequence similarity 3, member B

chr20_-_43438881 3.927 NM_001205317
NM_182970
RIMS4

regulating synaptic membrane exocytosis 4

chr19_-_42569921 3.892 NM_002088
GRIK5
glutamate receptor, ionotropic, kainate 5
chr19_-_7701852 3.885


chr1_+_37940180 3.855 ZC3H12A
zinc finger CCCH-type containing 12A
chr17_-_34079896 3.819 NM_139285
GAS2L2
growth arrest-specific 2 like 2
chr11_-_2019070 3.752 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr11_+_1861431 3.705 NM_001145841
TNNI2
troponin I type 2 (skeletal, fast)
chr2_+_223289285 3.637 NM_152386
SGPP2
sphingosine-1-phosphate phosphatase 2
chr19_-_55895602 3.611 NM_001190764
TMEM238
transmembrane protein 238
chr2_-_175869910 3.520 NM_001822
NM_001025201
CHN1

chimerin (chimaerin) 1

chr1_-_40782826 3.507 COL9A2
collagen, type IX, alpha 2
chr20_+_13976263 3.461 MACROD2
MACRO domain containing 2
chr11_+_113931228 3.458 NM_001018011
ZBTB16
zinc finger and BTB domain containing 16
chr1_-_153283166 3.449 NM_052891
PGLYRP3
peptidoglycan recognition protein 3
chr5_+_159343739 3.433 NM_000679
ADRA1B
adrenergic, alpha-1B-, receptor
chr17_-_66596934 3.429 NM_001243746
NM_017565
FAM20A

family with sequence similarity 20, member A

chr19_-_42498320 3.418 NM_152296
ATP1A3
ATPase, Na+/K+ transporting, alpha 3 polypeptide
chr19_+_54926604 3.409 NM_001005367
NM_001201461
NM_020659
TTYH1


tweety homolog 1 (Drosophila)


chr5_-_132948222 3.402 NM_015082
FSTL4
follistatin-like 4
chr10_+_102821552 3.400 KAZALD1
Kazal-type serine peptidase inhibitor domain 1
chr7_+_12726910 3.361 NM_001195396
NM_005738
ARL4A

ADP-ribosylation factor-like 4A

chr4_+_2420671 3.326 NM_001193282
LOC402160
uncharacterized LOC402160
chr4_+_3443691 3.323 NM_001528
HGFAC
HGF activator
chr16_+_67465019 3.315 NM_000196
HSD11B2
hydroxysteroid (11-beta) dehydrogenase 2
chr8_-_27850368 3.272 NM_173833
SCARA5
scavenger receptor class A, member 5 (putative)
chr16_+_23194037 3.261 NM_001039
SCNN1G
sodium channel, nonvoltage-gated 1, gamma
chr1_-_12677347 3.257 NM_004753
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr14_+_72398816 3.254 NM_001204423
RGS6
regulator of G-protein signaling 6
chr10_-_1779669 3.243 NM_018702
ADARB2
adenosine deaminase, RNA-specific, B2
chrX_-_153775427 3.169 G6PD
glucose-6-phosphate dehydrogenase
chr19_+_57154526 3.163 NM_001193628
LOC147670
uncharacterized LOC147670
chr10_-_98945662 3.163 NM_003061
SLIT1
slit homolog 1 (Drosophila)
chr21_-_43187265 3.150 RIPK4
receptor-interacting serine-threonine kinase 4
chr10_+_70587562 3.111 NM_001130162
STOX1
storkhead box 1
chr2_-_101767714 3.109 NM_001102426
TBC1D8
TBC1 domain family, member 8 (with GRAM domain)
chr10_-_98945379 3.090 SLIT1
slit homolog 1 (Drosophila)
chr4_+_129732427 3.057 PHF17
PHD finger protein 17
chr9_+_129677046 3.047 NM_001190729
NM_001190730
NM_014636
RALGPS1


Ral GEF with PH domain and SH3 binding motif 1


chr10_-_61122219 3.043 NM_001001971
NM_001166698
NM_198215
FAM13C


family with sequence similarity 13, member C


chr8_-_124553448 3.032 NM_001242463
NM_058229
FBXO32

F-box protein 32

chr21_-_43187197 3.027 NM_020639
RIPK4
receptor-interacting serine-threonine kinase 4
chr7_+_12610202 3.004 NM_001112706
SCIN
scinderin
chr9_+_115249078 2.971 NM_133465
KIAA1958
KIAA1958
chr1_-_59248287 2.947 JUN
jun proto-oncogene
chr1_-_33168263 2.906 SYNC
syncoilin, intermediate filament protein
chr19_-_47735858 2.898 NM_001127240
NM_001127241
NM_001127242
BBC3


BCL2 binding component 3


chr19_-_57183122 2.884 NM_001005850
ZNF835
zinc finger protein 835
chr10_+_102820914 2.882 NM_030929
KAZALD1
Kazal-type serine peptidase inhibitor domain 1
chr1_-_40782924 2.881 NM_001852
COL9A2
collagen, type IX, alpha 2
chr19_-_16008870 2.848 NM_001082
CYP4F2
cytochrome P450, family 4, subfamily F, polypeptide 2
chr17_+_20224457 2.847 CCDC144C
coiled-coil domain containing 144C
chr14_-_107199126 2.841 IGHG3
immunoglobulin heavy constant gamma 3 (G3m marker)
chr14_+_72399149 2.828 NM_001204424
RGS6
regulator of G-protein signaling 6
chr2_+_79740059 2.823 NM_001164883
NM_004389
CTNNA2

catenin (cadherin-associated protein), alpha 2

chr11_-_1606480 2.821 NM_001005922
KRTAP5-1
keratin associated protein 5-1
chr4_-_657424 2.794


chr4_+_3443659 2.789 HGFAC
HGF activator
chr1_-_92351476 2.789 TGFBR3
transforming growth factor, beta receptor III
chr10_+_5566923 2.781 NM_005185
CALML3
calmodulin-like 3
chr5_-_80689948 2.754 NM_130767
ACOT12
acyl-CoA thioesterase 12
chr6_+_44095357 2.744 NM_018426
TMEM63B
transmembrane protein 63B
chr1_-_23857711 2.728 NM_004091
E2F2
E2F transcription factor 2
chr11_-_2018885 2.720 H19
RPS12
H19, imprinted maternally expressed transcript (non-protein coding)
ribosomal protein S12
chrX_-_153775064 2.718 NM_000402
G6PD
glucose-6-phosphate dehydrogenase
chr14_-_23288912 2.698 NM_001126106
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr18_+_67068134 2.697 NM_152721
DOK6
docking protein 6
chr17_-_8702438 2.687 NM_152599
MFSD6L
major facilitator superfamily domain containing 6-like
chr16_+_58497628 2.679 NDRG4
NDRG family member 4
chr11_-_2291809 2.678 ASCL2
achaete-scute complex homolog 2 (Drosophila)
chr16_+_87636574 2.671 JPH3
junctophilin 3
chr8_-_124553253 2.669 FBXO32
F-box protein 32
chr20_-_60942300 2.665 NM_005560
LAMA5
laminin, alpha 5
chr19_-_47137938 2.653 NM_033258
GNG8
guanine nucleotide binding protein (G protein), gamma 8
chr14_-_58332591 2.648 NM_001206920
SLC35F4
solute carrier family 35, member F4
chr5_-_95767862 2.648 NM_001177875
PCSK1
proprotein convertase subtilisin/kexin type 1
chr4_-_42658883 2.647 NM_001105529
NM_006095
ATP8A1

ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1

chr16_+_84178864 2.633 NM_178452
DNAAF1
dynein, axonemal, assembly factor 1
chr1_-_92351613 2.632 NM_001195683
NM_003243
TGFBR3

transforming growth factor, beta receptor III

chrX_-_118827060 2.631 SEPT6
septin 6
chr4_+_8582216 2.627 NM_080819
GPR78
G protein-coupled receptor 78
chr2_-_157189040 2.619 NM_006186
NR4A2
nuclear receptor subfamily 4, group A, member 2
chr17_-_3500335 2.614 NM_018727
TRPV1
transient receptor potential cation channel, subfamily V, member 1
chr9_-_91793375 2.613 SHC3
SHC (Src homology 2 domain containing) transforming protein 3
chr11_-_119252364 2.603 NM_001243759
NM_004205
USP2

ubiquitin specific peptidase 2

chr15_-_74501309 2.592 NM_001142617
NM_001142619
NM_001142620
STRA6


stimulated by retinoic acid gene 6 homolog (mouse)


chrX_-_20135015 2.590 NM_001168465
NM_001168466
NM_152780
MAP7D2


MAP7 domain containing 2


chrX_-_20134749 2.587 NM_001168467
MAP7D2
MAP7 domain containing 2
chr4_-_16085309 2.583 PROM1
prominin 1
chr1_+_9352955 2.567 SPSB1
splA/ryanodine receptor domain and SOCS box containing 1
chr1_-_92949045 2.550 GFI1
growth factor independent 1 transcription repressor
chr19_-_46272496 2.547 NM_175875
SIX5
SIX homeobox 5
chr17_+_79495416 2.546 NM_001077182
NM_012418
FSCN2

fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)

chr3_-_93747453 2.542 NM_001001850
STX19
syntaxin 19
chr11_-_2018568 2.536 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr11_+_7535213 2.533 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr1_-_53018721 2.529 NM_001009881
NM_015269
ZCCHC11

zinc finger, CCHC domain containing 11

chr3_-_187454247 2.519 NM_001130845
BCL6
B-cell CLL/lymphoma 6
chr11_-_2018446 2.519 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr22_-_17602142 2.509 NM_031890
NM_001163079
CECR6

cat eye syndrome chromosome region, candidate 6

chr15_+_23810808 2.507 MKRN3
makorin ring finger protein 3
chr14_-_67982020 2.497 NM_182526
TMEM229B
transmembrane protein 229B
chr1_-_57285368 2.486 NM_001004303
C1orf168
chromosome 1 open reading frame 168
chr17_-_39211462 2.485 NM_033032
KRTAP2-2
keratin associated protein 2-2
chr1_-_92949355 2.473 NM_001127215
GFI1
growth factor independent 1 transcription repressor
chr19_-_39523132 2.472 NM_178820
FBXO27
F-box protein 27
chr9_-_40792062 2.459 NM_033160
ZNF658
zinc finger protein 658
chr17_-_20799332 2.445 NM_001004306
CCDC144NL
coiled-coil domain containing 144 family, N-terminal like
chr19_+_50191920 2.443 NM_001101340
C19orf76
chromosome 19 open reading frame 76
chr20_+_43029865 2.442 NM_000457
NM_178849
NM_178850
HNF4A


hepatocyte nuclear factor 4, alpha


chrX_-_118827116 2.440 SEPT6
septin 6
chrX_-_153775002 2.432 G6PD
glucose-6-phosphate dehydrogenase
chr16_+_58497548 2.423 NM_020465
NDRG4
NDRG family member 4
chr19_-_17559375 2.421 NM_001190844
TMEM221
transmembrane protein 221
chr11_-_2019007 2.418 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr9_-_101470836 2.410 NM_005458
GABBR2
gamma-aminobutyric acid (GABA) B receptor, 2
chr7_-_150864866 2.409 NM_001098834
GBX1
gastrulation brain homeobox 1
chr14_-_106877689 2.405 IGHV4-31
IGH@
IGHA1
IGHA2
IGHG1
IGHG4
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy locus
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 4 (G4m marker)
immunoglobulin heavy constant mu
chr17_-_36762105 2.405 NM_025248
SRCIN1
SRC kinase signaling inhibitor 1
chr11_-_8190535 2.402 NM_001135109
NM_001206671
NM_001206672
NM_024557
RIC3



resistance to inhibitors of cholinesterase 3 homolog (C. elegans)



chr10_-_98945580 2.383 SLIT1
slit homolog 1 (Drosophila)
chr19_-_11689765 2.382 NM_001111035
NM_001111036
ACP5

acid phosphatase 5, tartrate resistant

chr5_+_126112847 2.374 LMNB1
lamin B1
chr7_+_148036528 2.364 CNTNAP2
contactin associated protein-like 2
chr12_-_95942570 2.363 NM_001042403
USP44
ubiquitin specific peptidase 44
chr8_+_145086444 2.361 NM_001134374
NM_198572
SPATC1

spermatogenesis and centriole associated 1

chr11_+_64107687 2.360 NM_032251
CCDC88B
coiled-coil domain containing 88B
chr14_+_100150596 2.358 NM_006668
CYP46A1
cytochrome P450, family 46, subfamily A, polypeptide 1
chr11_-_124632050 2.355 NM_138961
ESAM
endothelial cell adhesion molecule
chr10_+_11060069 2.352 CELF2
CUGBP, Elav-like family member 2
chr4_-_16085593 2.350 NM_001145847
NM_001145848
PROM1

prominin 1

chr19_+_56159400 2.349 CCDC106
coiled-coil domain containing 106
chr19_+_50194348 2.347 NM_001136052
NM_001199752
NM_001199753
NM_152359
CPT1C



carnitine palmitoyltransferase 1C



chr17_-_8868931 2.335 NM_001142633
NM_001251851
NM_001251852
NM_001251853
NM_001251855
PIK3R5




phosphoinositide-3-kinase, regulatory subunit 5




chr14_-_107083398 2.334 IGH@
IGHA1
IGHG1
immunoglobulin heavy locus
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr1_+_9352931 2.334 NM_025106
SPSB1
splA/ryanodine receptor domain and SOCS box containing 1
chr9_+_116226006 2.331 NM_017790
RGS3
regulator of G-protein signaling 3
chr16_+_87636669 2.328 JPH3
junctophilin 3
chr16_+_58497993 2.323 NM_001130487
NDRG4
NDRG family member 4
chr2_+_198669316 2.322 NM_006226
PLCL1
phospholipase C-like 1
chr11_-_119252267 2.319 USP2
ubiquitin specific peptidase 2
chr9_+_92219926 2.314 NM_006705
GADD45G
growth arrest and DNA-damage-inducible, gamma
chr22_-_18923654 2.313 PRODH
proline dehydrogenase (oxidase) 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.58 2.56e-06 GO:0048731 system development
1.75 2.76e-06 GO:0048513 organ development
1.49 8.91e-06 GO:0007275 multicellular organismal development
1.52 9.53e-06 GO:0048856 anatomical structure development
1.46 1.22e-05 GO:0032502 developmental process
1.65 6.28e-05 GO:0030154 cell differentiation
1.62 1.52e-04 GO:0048869 cellular developmental process
1.30 3.51e-03 GO:0032501 multicellular organismal process
1.20 1.09e-02 GO:0065007 biological regulation
1.97 1.72e-02 GO:0009719 response to endogenous stimulus
1.78 4.40e-02 GO:0006811 ion transport
2.36 4.57e-02 GO:0044057 regulation of system process
1.21 4.95e-02 GO:0050794 regulation of cellular process

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.40 8.42e-06 GO:0071944 cell periphery
1.40 1.12e-05 GO:0005886 plasma membrane
1.51 7.92e-04 GO:0044459 plasma membrane part
1.44 1.55e-02 GO:0005576 extracellular region
1.56 2.99e-02 GO:0031226 intrinsic to plasma membrane
2.50 4.26e-02 GO:0034702 ion channel complex
1.55 4.99e-02 GO:0005887 integral to plasma membrane

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
3.89 1.33e-03 GO:0019838 growth factor binding
1.98 1.74e-03 GO:0043565 sequence-specific DNA binding
1.88 4.92e-03 GO:0015075 ion transmembrane transporter activity
7.91 7.14e-03 GO:0005520 insulin-like growth factor binding
1.94 2.14e-02 GO:0008324 cation transmembrane transporter activity
1.67 4.47e-02 GO:0022857 transmembrane transporter activity
5.20 4.91e-02 GO:0003823 antigen binding