Motif ID: LEF1_TCF7_TCF7L1,2.p2

Z-value: 1.084


Transcription factors associated with LEF1_TCF7_TCF7L1,2.p2:

Gene SymbolEntrez IDGene Name
LEF1 51176 lymphoid enhancer-binding factor 1
TCF7 6932 transcription factor 7 (T-cell specific, HMG-box)
TCF7L1 83439 transcription factor 7-like 1 (T-cell specific, HMG-box)
TCF7L2 6934 transcription factor 7-like 2 (T-cell specific, HMG-box)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TCF7L2hg19_v1_chr10_+_114709963_114710641-0.388.2e-04Click!
TCF7L1hg19_v1_chr2_+_85360373_853609460.388.4e-04Click!
TCF7hg19_v1_chr5_+_133451297_1334514260.371.2e-03Click!
LEF1hg19_v1_chr4_-_109089444_1090901540.334.3e-03Click!


Activity profile for motif LEF1_TCF7_TCF7L1,2.p2.

activity profile for motif LEF1_TCF7_TCF7L1,2.p2


Sorted Z-values histogram for motif LEF1_TCF7_TCF7L1,2.p2

Sorted Z-values for motif LEF1_TCF7_TCF7L1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of LEF1_TCF7_TCF7L1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_8274179 10.739 NM_024552
CERS4
ceramide synthase 4
chrX_+_152760346 9.923 NM_001711
BGN
biglycan
chr6_-_89827605 9.700 NM_080743
SRSF12
serine/arginine-rich splicing factor 12
chr19_-_51522953 9.517 NM_145888
KLK10
kallikrein-related peptidase 10
chr1_-_151345156 8.452 NM_003944
SELENBP1
selenium binding protein 1
chrX_+_152760452 7.609 BGN
biglycan
chr9_+_17578952 7.281 NM_003026
SH3GL2
SH3-domain GRB2-like 2
chr12_-_28124915 6.257 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr10_-_5541401 6.048 NM_017422
CALML5
calmodulin-like 5
chr1_-_152539228 5.549 NM_178435
LCE3E
late cornified envelope 3E
chr17_-_48072566 5.318 NM_005220
DLX3
distal-less homeobox 3
chr15_+_25068793 5.049 NM_022806
NM_022807
NM_022808
SNRPN


small nuclear ribonucleoprotein polypeptide N


chr11_+_66790189 4.902 NM_001177880
SYT12
synaptotagmin XII
chr1_+_100111430 4.720 NM_017734
PALMD
palmdelphin
chr3_+_132757170 4.710 NM_001136469
NM_023943
TMEM108

transmembrane protein 108

chr13_-_99910548 4.294 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chr5_+_140254930 4.240 NM_018903
NM_031864
PCDHA12

protocadherin alpha 12

chr14_-_21493122 4.224 NM_201538
NM_201539
NM_201540
NM_201541
NDRG2



NDRG family member 2



chr17_-_56358266 4.133 NM_000250
MPO
myeloperoxidase
chr2_-_86564632 4.126 NM_001164731
NM_001164732
NM_022912
REEP1


receptor accessory protein 1


chr2_-_231989755 4.061 NM_000867
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B
chr6_-_11779279 3.960 NM_001143948
NM_032744
C6orf105

chromosome 6 open reading frame 105

chr17_-_63556443 3.905 AXIN2
axin 2
chr12_-_57328044 3.896 NM_148897
SDR9C7
short chain dehydrogenase/reductase family 9C, member 7
chr1_-_152779106 3.876 NM_178351
LCE1C
late cornified envelope 1C
chr8_+_32579350 3.707 NM_001159996
NRG1
neuregulin 1
chr7_-_83278478 3.575 NM_012431
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr14_-_21502943 3.565 NM_001012264
RNASE13
ribonuclease, RNase A family, 13 (non-active)
chr19_-_375969 3.513 NM_016585
NM_199202
THEG

Theg homolog (mouse)

chrX_+_102632108 3.472 NM_014380
NGFRAP1
nerve growth factor receptor (TNFRSF16) associated protein 1
chr14_-_58618807 3.378 NM_001001872
C14orf37
chromosome 14 open reading frame 37
chr13_+_53602829 3.361 NM_006418
OLFM4
olfactomedin 4
chr17_-_39093671 3.325 NM_015515
KRT23
keratin 23 (histone deacetylase inducible)
chr5_-_157002739 3.271 NM_033274
ADAM19
ADAM metallopeptidase domain 19
chr17_-_56358118 3.181 MPO
myeloperoxidase
chr17_-_56358161 3.156 MPO
myeloperoxidase
chr15_-_82338348 3.156 NM_032246
MEX3B
mex-3 homolog B (C. elegans)
chr19_-_55690717 3.115 SYT5
synaptotagmin V
chr5_+_140235594 3.083 NM_018901
NM_031859
NM_031860
PCDHA10


protocadherin alpha 10


chr17_-_39211462 3.073 NM_033032
KRTAP2-2
keratin associated protein 2-2
chr7_-_106301329 3.062 NM_175884
C7orf74
chromosome 7 open reading frame 74
chr17_-_78450247 2.997 NM_002522
NPTX1
neuronal pentraxin I
chr9_-_123689172 2.968 NM_005658
TRAF1
TNF receptor-associated factor 1
chr16_-_49315682 2.955 NM_004352
CBLN1
cerebellin 1 precursor
chr1_+_153330329 2.919 NM_002965
S100A9
S100 calcium binding protein A9
chr1_-_110933635 2.905 SLC16A4
solute carrier family 16, member 4 (monocarboxylic acid transporter 5)
chr19_-_51504799 2.884 NM_007196
NM_144505
NM_144506
NM_144507
KLK8



kallikrein-related peptidase 8



chr19_+_56879687 2.884 ZNF542
zinc finger protein 542
chr2_-_100722328 2.860 AFF3
AF4/FMR2 family, member 3
chr2_-_208031570 2.847 KLF7
Kruppel-like factor 7 (ubiquitous)
chr19_+_46733008 2.818 NM_198541
IGFL1
IGF-like family member 1
chr5_-_16936371 2.815 NM_012334
MYO10
myosin X
chr14_-_94443065 2.805 NM_001202429
ASB2
ankyrin repeat and SOCS box containing 2
chr14_-_58618916 2.798 C14orf37
chromosome 14 open reading frame 37
chr5_-_16936290 2.788 MYO10
myosin X
chr6_-_29527477 2.777 UBD
ubiquitin D
chr10_-_116164514 2.774 NM_001001936
NM_032550
AFAP1L2

actin filament associated protein 1-like 2

chrX_-_106362018 2.707 RBM41
RNA binding motif protein 41
chr2_+_219724545 2.703 NM_006522
WNT6
wingless-type MMTV integration site family, member 6
chr5_-_100238870 2.702 NM_175052
NM_005668
ST8SIA4

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4

chr15_+_62359175 2.692 NM_207322
C2CD4A
C2 calcium-dependent domain containing 4A
chr7_+_29519485 2.689 NM_001039936
CHN2
chimerin (chimaerin) 2
chr19_-_18717467 2.662 CRLF1
cytokine receptor-like factor 1
chr17_-_39222126 2.649 NM_033184
KRTAP2-4
keratin associated protein 2-4
chr19_+_51152634 2.640 NM_001195076
C19orf81
chromosome 19 open reading frame 81
chr9_+_139877444 2.615 NM_207510
LCNL1
lipocalin-like 1
chr6_-_29527701 2.606 NM_006398
UBD
ubiquitin D
chr18_+_11751470 2.591 NM_001142339
NM_002071
GNAL

guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type

chr7_+_80275967 2.584 CD36
CD36 molecule (thrombospondin receptor)
chr10_+_5566923 2.578 NM_005185
CALML3
calmodulin-like 3
chrX_-_108725284 2.566 NM_001522
GUCY2F
guanylate cyclase 2F, retinal
chr15_-_82338459 2.523 MEX3B
mex-3 homolog B (C. elegans)
chr10_+_90562486 2.516 NM_001128215
LIPM
lipase, family member M
chr8_-_121824015 2.511


chr5_-_16738346 2.498 MYO10
myosin X
chr5_-_157002705 2.468


chr19_-_37958338 2.460 NM_152484
ZNF569
zinc finger protein 569
chr19_-_18717631 2.453 NM_004750
CRLF1
cytokine receptor-like factor 1
chr7_-_91794589 2.444 NM_001161528
LRRD1
leucine-rich repeats and death domain containing 1
chr22_+_24105207 2.439 NM_182520
C22orf15
chromosome 22 open reading frame 15
chr1_+_200993041 2.430


chr7_+_29234111 2.415 NM_004067
CHN2
chimerin (chimaerin) 2
chr2_+_16080639 2.396 NM_005378
MYCN
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
chr17_-_39525873 2.391 NM_002279
KRT33B
keratin 33B
chr18_-_31802433 2.375 NM_001198547
NOL4
nucleolar protein 4
chr7_+_80231503 2.364 NM_001001547
CD36
CD36 molecule (thrombospondin receptor)
chr7_+_80275634 2.354 NM_001127443
NM_001127444
CD36

CD36 molecule (thrombospondin receptor)

chr10_+_7745341 2.320 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chrX_+_125953746 2.305 NM_001122716
CXorf64
chromosome X open reading frame 64
chr2_+_98330030 2.267 NM_001079
ZAP70
zeta-chain (TCR) associated protein kinase 70kDa
chr1_-_177133950 2.261 NM_004319
NM_207108
ASTN1

astrotactin 1

chr6_+_153019029 2.239 NM_025107
MYCT1
myc target 1
chr12_+_80603232 2.237 NM_173591
OTOGL
otogelin-like
chr15_+_23810453 2.214 NM_005664
MKRN3
makorin ring finger protein 3
chr11_+_63137260 2.213 NM_080866
SLC22A9
solute carrier family 22 (organic anion transporter), member 9
chr2_-_100722259 2.211 AFF3
AF4/FMR2 family, member 3
chr2_-_107503517 2.210 NM_001142352
NM_032528
ST6GAL2

ST6 beta-galactosamide alpha-2,6-sialyltranferase 2

chr1_+_185703470 2.207 NM_031935
HMCN1
hemicentin 1
chr10_-_50396380 2.205 NM_001010863
C10orf128
chromosome 10 open reading frame 128
chrX_-_128788913 2.187 NM_017413
APLN
apelin
chr8_-_70745403 2.187 NM_001146009
SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr1_-_161993586 2.175 NM_015441
OLFML2B
olfactomedin-like 2B
chr2_-_170218972 2.163 LRP2
low density lipoprotein receptor-related protein 2
chr1_-_110933683 2.161 NM_001201546
NM_001201547
NM_001201548
NM_001201549
NM_004696
SLC16A4




solute carrier family 16, member 4 (monocarboxylic acid transporter 5)




chr15_-_65670325 2.152 NM_004884
IGDCC3
immunoglobulin superfamily, DCC subclass, member 3
chr10_+_7745354 2.150 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr4_-_186877413 2.143 SORBS2
sorbin and SH3 domain containing 2
chr5_+_140480056 2.135 NM_018937
PCDHB3
protocadherin beta 3
chr2_+_16080559 2.116 MYCN
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
chr9_-_102582143 2.086


chr1_-_177134042 2.082 ASTN1
astrotactin 1
chr17_-_46871596 2.078 NM_173623
TTLL6
tubulin tyrosine ligase-like family, member 6
chr8_-_119964059 2.078 NM_002546
TNFRSF11B
tumor necrosis factor receptor superfamily, member 11b
chr1_-_177133818 2.076 ASTN1
astrotactin 1
chr11_-_20181869 2.075 NM_001029865
DBX1
developing brain homeobox 1
chr20_+_30555804 2.072 NM_001011718
XKR7
XK, Kell blood group complex subunit-related family, member 7
chr17_-_16472463 2.069 NM_020653
ZNF287
zinc finger protein 287
chr19_-_17375522 2.066 NM_031941
USHBP1
Usher syndrome 1C binding protein 1
chr6_-_71012750 2.061 NM_001851
COL9A1
collagen, type IX, alpha 1
chr17_+_59529778 2.058 TBX4
T-box 4
chr19_-_18717577 2.057 CRLF1
cytokine receptor-like factor 1
chr12_-_25706177 2.036 NM_152590
NM_001145728
NM_001145729
IFLTD1


intermediate filament tail domain containing 1


chrX_+_30260056 2.033 NM_002367
MAGEB4
melanoma antigen family B, 4
chr1_+_152730505 2.030 NM_001025231
KPRP
keratinocyte proline-rich protein
chr17_-_39580657 2.030 NM_003770
KRT37
keratin 37
chr14_-_94442894 2.024 ASB2
ankyrin repeat and SOCS box containing 2
chr15_-_90294359 2.021 NM_018670
MESP1
mesoderm posterior 1 homolog (mouse)
chr2_+_27070962 2.020 NM_020134
NM_001253723
NM_001253724
DPYSL5


dihydropyrimidinase-like 5


chr2_-_46384 2.018 NM_001077710
FAM110C
family with sequence similarity 110, member C
chr5_+_55149149 2.001 NM_001242636
NM_001242639
IL31RA

interleukin 31 receptor A

chr2_+_48796158 1.999 NM_172311
STON1-GTF2A1L
STON1-GTF2A1L readthrough
chr15_+_65134081 1.987 NM_001195059
NM_025201
PLEKHO2

pleckstrin homology domain containing, family O member 2

chr1_+_160160284 1.987 NM_001231
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr7_+_94023872 1.978 NM_000089
COL1A2
collagen, type I, alpha 2
chr11_+_46740736 1.978 NM_000506
F2
coagulation factor II (thrombin)
chr8_+_121823538 1.973


chr19_+_18062110 1.972 NM_002248
KCNN1
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1
chrX_+_13587693 1.969 NM_001167890
NM_015507
EGFL6

EGF-like-domain, multiple 6

chr10_+_71562275 1.965 COL13A1
collagen, type XIII, alpha 1
chr12_+_70759974 1.959 NM_014505
KCNMB4
potassium large conductance calcium-activated channel, subfamily M, beta member 4
chr20_+_42965625 1.948 NM_178491
R3HDML
R3H domain containing-like
chr17_-_38020421 1.929 NM_012481
NM_183228
NM_183229
NM_183230
NM_183231
NM_183232
IKZF3





IKAROS family zinc finger 3 (Aiolos)





chr12_-_133464151 1.925 CHFR
checkpoint with forkhead and ring finger domains
chr15_+_80696569 1.916 NM_014862
ARNT2
aryl-hydrocarbon receptor nuclear translocator 2
chr22_-_45404785 1.907 NM_001242450
PHF21B
PHD finger protein 21B
chr7_-_139876718 1.905 NM_030647
JHDM1D
jumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae)
chr5_+_140174443 1.894 NM_018905
NM_031495
PCDHA2

protocadherin alpha 2

chr12_-_133464197 1.878 NM_001161344
NM_001161345
NM_001161346
NM_001161347
NM_018223
CHFR




checkpoint with forkhead and ring finger domains




chr13_+_29598746 1.876 NM_001033602
MTUS2
microtubule associated tumor suppressor candidate 2
chr20_+_30598244 1.868 NM_080625
C20orf160
chromosome 20 open reading frame 160
chr17_-_42081836 1.863 NM_004160
PYY
peptide YY
chr12_-_16759531 1.862 NM_018640
LMO3
LIM domain only 3 (rhombotin-like 2)
chrX_+_48620153 1.861 NM_001080489
GLOD5
glyoxalase domain containing 5
chr17_+_30813928 1.853 NM_003885
CDK5R1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr20_+_55966440 1.851 NM_017495
NM_183425
RBM38

RNA binding motif protein 38

chrX_+_46937744 1.850 NM_004683
NM_152869
RGN

regucalcin (senescence marker protein-30)

chr15_+_50474357 1.840 NM_001159629
NM_003645
SLC27A2

solute carrier family 27 (fatty acid transporter), member 2

chr12_+_20963637 1.838 NM_019844
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr6_-_160679789 1.826 NM_003058
SLC22A2
solute carrier family 22 (organic cation transporter), member 2
chr8_-_70745624 1.825 NM_001146008
SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr18_+_29769986 1.819 NM_005925
MEP1B
meprin A, beta
chr1_+_24882565 1.805 NM_001010980
C1orf130
chromosome 1 open reading frame 130
chr8_-_95220769 1.799 NM_004063
CDH17
cadherin 17, LI cadherin (liver-intestine)
chr9_-_35650852 1.796 NM_014450
SIT1
signaling threshold regulating transmembrane adaptor 1
chr21_-_31538970 1.796 NM_012131
CLDN17
claudin 17
chr12_-_98897622 1.784 LOC643770
uncharacterized LOC643770
chr20_+_17207596 1.781 NM_001201529
NM_002594
PCSK2

proprotein convertase subtilisin/kexin type 2

chr1_-_95392501 1.781 NM_001839
CNN3
calponin 3, acidic
chr9_-_100707102 1.777 NM_018437
HEMGN
hemogen
chr3_+_123813527 1.776 NM_001024660
NM_003947
KALRN

kalirin, RhoGEF kinase

chr1_+_16330730 1.775 NM_178840
C1orf64
chromosome 1 open reading frame 64
chr1_+_17846818 1.768 ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr6_+_116850175 1.767 NM_153036
FAM26D
family with sequence similarity 26, member D
chr12_+_15475445 1.758 PTPRO
protein tyrosine phosphatase, receptor type, O
chr11_+_113848221 1.754 NM_001161772
HTR3A
5-hydroxytryptamine (serotonin) receptor 3A
chr10_-_98945379 1.744 SLIT1
slit homolog 1 (Drosophila)
chr13_-_28674646 1.743 NM_004119
FLT3
fms-related tyrosine kinase 3
chr8_-_121823696 1.739 SNTB1
syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
chr1_+_170633312 1.738 NM_006902
NM_022716
PRRX1

paired related homeobox 1

chr20_-_56284945 1.730 NM_020182
PMEPA1
prostate transmembrane protein, androgen induced 1
chr7_+_143140545 1.724 NM_177437
TAS2R60
taste receptor, type 2, member 60
chr10_+_7745325 1.717 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr8_-_143999255 1.716 NM_000498
CYP11B2
cytochrome P450, family 11, subfamily B, polypeptide 2
chr11_+_46740769 1.702 F2
coagulation factor II (thrombin)
chr10_-_13749622 1.699 FRMD4A
FERM domain containing 4A
chr10_+_124895566 1.696 NM_001105574
HMX3
H6 family homeobox 3
chr10_+_71561687 1.677 COL13A1
collagen, type XIII, alpha 1
chrX_+_115567746 1.674 NM_007231
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chrX_+_69488154 1.669 NM_004312
ARR3
arrestin 3, retinal (X-arrestin)
chr4_-_120243257 1.661 NM_000134
FABP2
fatty acid binding protein 2, intestinal
chr7_+_39017608 1.657 NM_001166018
NM_007252
POU6F2

POU class 6 homeobox 2

chr1_+_207039153 1.655 NM_018724
IL20
interleukin 20
chrX_+_47986602 1.652 NM_205856
SPACA5
sperm acrosome associated 5
chr2_+_185463292 1.652 ZNF804A
zinc finger protein 804A
chr12_+_4382882 1.648 NM_001759
CCND2
cyclin D2
chr2_-_135782246 1.647 NM_001018046
NM_025052
YSK4

YSK4 Sps1/Ste20-related kinase homolog (S. cerevisiae)

chr3_-_190167597 1.640 NM_207316
TMEM207
transmembrane protein 207
chr19_-_39264144 1.638 NM_002307
LGALS7
LGALS7B
lectin, galactoside-binding, soluble, 7
lectin, galactoside-binding, soluble, 7B
chr2_+_179184970 1.638 NM_145739
OSBPL6
oxysterol binding protein-like 6
chrX_-_106362050 1.628 NM_001171080
NM_018301
RBM41

RNA binding motif protein 41


Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.49 1.25e-04 GO:0032501 multicellular organismal process
1.65 1.54e-04 GO:0007275 multicellular organismal development
1.57 1.01e-03 GO:0032502 developmental process
1.66 3.03e-03 GO:0048731 system development
1.60 4.38e-03 GO:0048856 anatomical structure development

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
2.15 1.13e-03 GO:0044421 extracellular region part
1.73 2.09e-03 GO:0005576 extracellular region
1.62 1.55e-02 GO:0044459 plasma membrane part
3.79 1.71e-02 GO:0005882 intermediate filament
2.66 3.43e-02 GO:0031012 extracellular matrix
1.39 3.78e-02 GO:0005886 plasma membrane

Nothing significant found in function category.