Motif ID: KLF12.p2

Z-value: 2.373


Transcription factors associated with KLF12.p2:

Gene SymbolEntrez IDGene Name
KLF12 11278 Kruppel-like factor 12

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
KLF12hg19_v1_chr13_-_74707913_74708065-0.056.6e-01Click!


Activity profile for motif KLF12.p2.

activity profile for motif KLF12.p2


Sorted Z-values histogram for motif KLF12.p2

Sorted Z-values for motif KLF12.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of KLF12.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_137801166 20.666 EGR1
early growth response 1
chr5_+_137801178 19.806 NM_001964
EGR1
early growth response 1
chr19_-_35981345 16.222 NM_001244847
NM_207392
KRTDAP

keratinocyte differentiation-associated protein

chr2_-_73520448 13.432 NM_001965
EGR4
early growth response 4
chr17_-_80797889 9.496 NM_024702
ZNF750
zinc finger protein 750
chr8_-_22550057 9.048 NM_001199881
EGR3
early growth response 3
chr3_+_42544131 8.860 VIPR1
vasoactive intestinal peptide receptor 1
chr5_+_159343739 8.793 NM_000679
ADRA1B
adrenergic, alpha-1B-, receptor
chr1_+_164528914 8.637 PBX1
pre-B-cell leukemia homeobox 1
chr17_+_1665342 8.619 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr18_-_45663667 8.241 NM_001039360
ZBTB7C
zinc finger and BTB domain containing 7C
chr10_-_64576074 7.864 EGR2
early growth response 2
chr13_+_43136871 7.739 NM_033012
TNFSF11
tumor necrosis factor (ligand) superfamily, member 11
chr17_+_1665306 7.176 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr7_+_100136784 7.166 NM_006076
AGFG2
ArfGAP with FG repeats 2
chr8_-_22550456 7.163 EGR3
early growth response 3
chr17_+_1665281 7.141 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr7_+_100136845 7.124 AGFG2
ArfGAP with FG repeats 2
chr1_-_46598250 7.079 NM_003629
NM_001114172
PIK3R3

phosphoinositide-3-kinase, regulatory subunit 3 (gamma)

chr1_-_32827843 7.007 NM_001167676
LOC100128071
uncharacterized LOC100128071
chr2_+_219745243 6.922 NM_025216
WNT10A
wingless-type MMTV integration site family, member 10A
chr19_+_2249112 6.798 NM_000479
AMH
anti-Mullerian hormone
chr1_+_32827797 6.469 NM_052841
TSSK3
testis-specific serine kinase 3
chr17_-_48265912 6.298 COL1A1
collagen, type I, alpha 1
chr1_-_22469414 6.234 NM_030761
WNT4
wingless-type MMTV integration site family, member 4
chr19_+_45971249 6.146 NM_001114171
NM_006732
FOSB

FBJ murine osteosarcoma viral oncogene homolog B

chr7_+_142552547 6.045 NM_004445
EPHB6
EPH receptor B6
chr2_+_85980600 5.931 NM_032827
ATOH8
atonal homolog 8 (Drosophila)
chr4_-_57522469 5.837 NM_001145459
NM_139211
HOPX

HOP homeobox

chr3_+_194407412 5.806 FAM43A
family with sequence similarity 43, member A
chr12_-_57351381 5.720 NM_003708
RDH16
retinol dehydrogenase 16 (all-trans)
chr14_+_95623991 5.662 DICER1-AS
DICER1 antisense RNA (non-protein coding)
chr11_+_113930430 5.609 NM_006006
ZBTB16
zinc finger and BTB domain containing 16
chr5_+_133842276 5.574


chr17_+_1665233 5.522 NM_002615
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr11_+_64981310 5.455 NM_001004326
SLC22A20
solute carrier family 22, member 20
chr3_-_169482847 5.447 TERC
telomerase RNA component
chr19_-_51512803 5.364 NM_012315
KLK9
kallikrein-related peptidase 9
chr2_-_220083394 5.335 ABCB6
ATP-binding cassette, sub-family B (MDR/TAP), member 6
chr9_-_73028278 5.316 KLF9
Kruppel-like factor 9
chr6_-_111136616 5.311 CDK19
cyclin-dependent kinase 19
chr19_+_13263890 5.260 IER2
immediate early response 2
chr13_+_43148182 5.251 NM_003701
TNFSF11
tumor necrosis factor (ligand) superfamily, member 11
chrX_+_49126326 5.248 PPP1R3F
protein phosphatase 1, regulatory subunit 3F
chr10_+_81002836 5.192 ZMIZ1
zinc finger, MIZ-type containing 1
chr11_+_113930296 5.134 ZBTB16
zinc finger and BTB domain containing 16
chr8_-_22549901 5.081 NM_001199880
EGR3
early growth response 3
chr11_-_8190535 5.050 NM_001135109
NM_001206671
NM_001206672
NM_024557
RIC3



resistance to inhibitors of cholinesterase 3 homolog (C. elegans)



chr3_+_42544094 5.018 NM_001251883
NM_001251884
NM_001251885
NM_004624
VIPR1



vasoactive intestinal peptide receptor 1



chr15_-_71407800 4.970 NM_001102658
CT62
cancer/testis antigen 62
chr11_-_8285299 4.941 NM_002315
LMO1
LIM domain only 1 (rhombotin 1)
chr20_-_39317875 4.940 NM_005461
MAFB
v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)
chr11_-_2018334 4.928 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr2_-_220083658 4.908 ABCB6
ATP-binding cassette, sub-family B (MDR/TAP), member 6
chr1_+_160370363 4.907 NM_020335
VANGL2
vang-like 2 (van gogh, Drosophila)
chr6_+_31730772 4.856 NM_001039651
C6orf26
chromosome 6 open reading frame 26
chr16_+_67198678 4.854 HSF4
heat shock transcription factor 4
chr10_-_64576123 4.828 NM_000399
NM_001136177
NM_001136179
EGR2


early growth response 2


chrX_+_49126299 4.821 NM_001184745
NM_033215
PPP1R3F

protein phosphatase 1, regulatory subunit 3F

chr7_+_28448970 4.800 LOC401317
uncharacterized LOC401317
chr2_-_220083699 4.764 NM_005689
ABCB6
ATP-binding cassette, sub-family B (MDR/TAP), member 6
chr5_-_81046858 4.758 SSBP2
single-stranded DNA binding protein 2
chr5_-_124080773 4.751 NM_020747
ZNF608
zinc finger protein 608
chr11_-_2018446 4.698 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr17_-_1548992 4.637 NM_003693
NM_145350
NM_145352
SCARF1


scavenger receptor class F, member 1


chr17_-_19619878 4.607 NM_001099646
NM_152908
SLC47A2

solute carrier family 47, member 2

chr5_-_172198160 4.600 NM_004417
DUSP1
dual specificity phosphatase 1
chr4_-_57522059 4.597 HOPX
HOP homeobox
chr11_-_119252364 4.539 NM_001243759
NM_004205
USP2

ubiquitin specific peptidase 2

chr17_-_48266572 4.529 COL1A1
collagen, type I, alpha 1
chr4_-_185726865 4.502 ACSL1
acyl-CoA synthetase long-chain family member 1
chr5_-_39203061 4.468 FYB
FYN binding protein
chr4_-_74964836 4.444 CXCL2
chemokine (C-X-C motif) ligand 2
chr6_-_111136506 4.441 CDK19
cyclin-dependent kinase 19
chr1_-_205912546 4.431 NM_052934
NM_134325
SLC26A9

solute carrier family 26, member 9

chr11_-_2018568 4.403 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr6_-_27782517 4.360 NM_021066
HIST1H2AJ
histone cluster 1, H2aj
chr10_-_102279590 4.359 NM_015490
SEC31B
SEC31 homolog B (S. cerevisiae)
chr11_-_46142955 4.347 NM_001101802
NM_016621
PHF21A

PHD finger protein 21A

chrX_-_53350521 4.325 NM_001111125
IQSEC2
IQ motif and Sec7 domain 2
chr17_-_40828441 4.295 NM_024927
PLEKHH3
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chr5_-_81046943 4.285 NM_012446
SSBP2
single-stranded DNA binding protein 2
chr19_-_45663407 4.263 NM_198478
NKPD1
NTPase, KAP family P-loop domain containing 1
chr15_+_47476225 4.254 NM_001198999
SEMA6D
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr15_-_41166336 4.238 NM_133639
RHOV
ras homolog gene family, member V
chr2_-_175712276 4.213 NM_001206602
CHN1
chimerin (chimaerin) 1
chr11_+_1860232 4.170 NM_003282
TNNI2
troponin I type 2 (skeletal, fast)
chr11_-_2017822 4.160 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr17_+_48172508 4.147 NM_001199900
NM_002611
NM_001199899
PDK2


pyruvate dehydrogenase kinase, isozyme 2


chr19_-_39402797 4.140 NM_001243212
LOC643669
uncharacterized LOC643669
chr16_+_67198583 4.120 HSF4
heat shock transcription factor 4
chr12_-_54778298 4.111 ZNF385A
zinc finger protein 385A
chr19_+_5914192 4.110 NM_004058
NM_080590
CAPS

calcyphosine

chr14_+_24837225 4.074 NM_001198965
NM_004554
NFATC4

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4

chr11_+_20070609 4.056 NAV2
neuron navigator 2
chr9_+_37650996 4.047 NM_014907
FRMPD1
FERM and PDZ domain containing 1
chr1_+_164528586 4.021 NM_001204961
NM_001204963
NM_002585
PBX1


pre-B-cell leukemia homeobox 1


chr16_+_85646923 4.005 NM_014615
KIAA0182
KIAA0182
chr6_-_111136407 4.001 NM_015076
CDK19
cyclin-dependent kinase 19
chr4_-_74964996 3.999 NM_002089
CXCL2
chemokine (C-X-C motif) ligand 2
chr1_-_11107150 3.994 MASP2
mannan-binding lectin serine peptidase 2
chr6_+_152126807 3.961 NM_001122741
ESR1
estrogen receptor 1
chr1_+_171810611 3.958 NM_001136127
NM_015569
DNM3

dynamin 3

chr6_+_89790464 3.957 PNRC1
proline-rich nuclear receptor coactivator 1
chr16_+_67198637 3.933 HSF4
heat shock transcription factor 4
chr1_-_38512446 3.852 NM_002699
POU3F1
POU class 3 homeobox 1
chr3_-_99833348 3.840 NM_001042459
NM_182909
FILIP1L

filamin A interacting protein 1-like

chr12_-_57328044 3.836 NM_148897
SDR9C7
short chain dehydrogenase/reductase family 9C, member 7
chr1_+_212781969 3.835 NM_001040619
NM_001206484
NM_001206488
NM_001674
ATF3



activating transcription factor 3



chr8_-_124553253 3.828 FBXO32
F-box protein 32
chr9_+_131085052 3.818 COQ4
coenzyme Q4 homolog (S. cerevisiae)
chrX_+_49126480 3.802 PPP1R3F
protein phosphatase 1, regulatory subunit 3F
chr8_-_108510094 3.801 NM_001146
NM_001199859
ANGPT1

angiopoietin 1

chr16_+_23194037 3.779 NM_001039
SCNN1G
sodium channel, nonvoltage-gated 1, gamma
chr17_-_47841517 3.778 NM_030802
FAM117A
family with sequence similarity 117, member A
chr7_+_80275967 3.764 CD36
CD36 molecule (thrombospondin receptor)
chr16_+_87636492 3.742 NM_020655
JPH3
junctophilin 3
chr19_-_1812198 3.728 NM_001178002
NM_138813
ATP8B3

ATPase, aminophospholipid transporter, class I, type 8B, member 3

chr6_+_89790412 3.721 NM_006813
PNRC1
proline-rich nuclear receptor coactivator 1
chrX_-_15288172 3.713 NM_001031739
NM_001168530
NM_024087
ASB9


ankyrin repeat and SOCS box containing 9


chr12_-_54778456 3.700 NM_015481
ZNF385A
zinc finger protein 385A
chr9_+_135937364 3.698 NM_001807
CEL
carboxyl ester lipase (bile salt-stimulated lipase)
chr3_-_49459870 3.676 AMT
aminomethyltransferase
chr17_-_34079896 3.660 NM_139285
GAS2L2
growth arrest-specific 2 like 2
chr11_+_7535213 3.647 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr10_+_23983674 3.641 NM_001098500
KIAA1217
KIAA1217
chr11_-_119252267 3.637 USP2
ubiquitin specific peptidase 2
chr17_-_8055684 3.622 NM_002616
PER1
period homolog 1 (Drosophila)
chr9_+_139871954 3.598 NM_000954
PTGDS
prostaglandin D2 synthase 21kDa (brain)
chr1_+_209941894 3.590 TRAF3IP3
TRAF3 interacting protein 3
chr2_+_11680079 3.570 NM_148903
GREB1
growth regulation by estrogen in breast cancer 1
chr22_-_30685485 3.562 NM_001037666
GATSL3
GATS protein-like 3
chr11_-_2018703 3.509 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr9_-_130533509 3.506 NM_001252334
NM_005489
SH2D3C

SH2 domain containing 3C

chr1_-_85741992 3.502 BCL10
B-cell CLL/lymphoma 10
chr1_+_48688356 3.498 NM_001011547
NM_001135181
SLC5A9

solute carrier family 5 (sodium/glucose cotransporter), member 9

chr8_-_145060594 3.488 NM_032789
PARP10
poly (ADP-ribose) polymerase family, member 10
chr6_-_11382501 3.443 NM_001142393
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr17_-_47841468 3.418 FAM117A
family with sequence similarity 117, member A
chr1_+_109792640 3.416 NM_001408
CELSR2
cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)
chr20_-_32307889 3.409 NM_007238
NM_183397
PXMP4

peroxisomal membrane protein 4, 24kDa

chr17_-_38978824 3.408 NM_000421
KRT10
keratin 10
chr4_-_149363498 3.407 NM_000901
NM_001166104
NR3C2

nuclear receptor subfamily 3, group C, member 2

chr13_-_67804432 3.406 NM_020403
NM_203487
PCDH9

protocadherin 9

chr8_-_145060563 3.405 PARP10
poly (ADP-ribose) polymerase family, member 10
chr5_-_95768660 3.398 NM_000439
PCSK1
proprotein convertase subtilisin/kexin type 1
chr19_+_50380681 3.396 NM_001168222
NM_024682
TBC1D17

TBC1 domain family, member 17

chr19_+_49838700 3.392 CD37
CD37 molecule
chr19_+_2476122 3.392 NM_015675
GADD45B
growth arrest and DNA-damage-inducible, beta
chr11_+_113931228 3.381 NM_001018011
ZBTB16
zinc finger and BTB domain containing 16
chr17_+_42634598 3.374 NM_001466
FZD2
frizzled family receptor 2
chr18_+_44497512 3.370 KATNAL2
katanin p60 subunit A-like 2
chr17_+_48262816 3.362


chr12_-_53074172 3.361 NM_006121
KRT1
keratin 1
chr9_+_131084745 3.351 NM_016035
COQ4
coenzyme Q4 homolog (S. cerevisiae)
chr11_-_128807712 3.331 NM_001195194
TP53AIP1
tumor protein p53 regulated apoptosis inducing protein 1
chr14_-_67982020 3.330 NM_182526
TMEM229B
transmembrane protein 229B
chr5_-_176936857 3.330 NM_024872
DOK3
docking protein 3
chr17_-_74533623 3.330 NM_134268
CYGB
cytoglobin
chr17_+_26699053 3.321 SARM1
sterile alpha and TIR motif containing 1
chr8_-_20112691 3.318 NM_021020
LZTS1
leucine zipper, putative tumor suppressor 1
chr1_+_212738675 3.314 NM_001030287
ATF3
activating transcription factor 3
chr10_-_123357503 3.295 NM_000141
NM_001144917
NM_001144918
NM_001144919
NM_022970
FGFR2




fibroblast growth factor receptor 2




chr20_-_2821245 3.278 NM_022760
FAM113A
family with sequence similarity 113, member A
chr22_-_40859423 3.268 MKL1
megakaryoblastic leukemia (translocation) 1
chr11_+_64120348 3.261 CCDC88B
coiled-coil domain containing 88B
chr17_-_48262900 3.246 COL1A1
collagen, type I, alpha 1
chr8_-_48650683 3.245 CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr20_+_306205 3.241 NM_006943
SOX12
SRY (sex determining region Y)-box 12
chr3_-_87040268 3.230 VGLL3
vestigial like 3 (Drosophila)
chr12_-_27235454 3.211 NM_001080406
C12orf71
chromosome 12 open reading frame 71
chr22_-_39268214 3.194 CBX6
chromobox homolog 6
chr17_+_73629513 3.187 NM_001162995
C17orf109
chromosome 17 open reading frame 109
chr10_+_5566923 3.181 NM_005185
CALML3
calmodulin-like 3
chr22_-_39268230 3.177 NM_014292
CBX6
chromobox homolog 6
chr2_+_241375207 3.164 GPC1
glypican 1
chr12_-_54694717 3.145 NM_001136023
NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr11_-_67442086 3.141 NM_000695
ALDH3B2
aldehyde dehydrogenase 3 family, member B2
chr19_-_46272102 3.139


chr9_+_116263706 3.135 NM_130795
RGS3
regulator of G-protein signaling 3
chr17_+_26699093 3.133 SARM1
sterile alpha and TIR motif containing 1
chr1_-_221915393 3.123 DUSP10
dual specificity phosphatase 10
chr6_-_111136330 3.123 CDK19
cyclin-dependent kinase 19
chr15_-_40401041 3.123 NM_001003940
BMF
Bcl2 modifying factor
chr10_+_23728197 3.092 NM_001145373
OTUD1
OTU domain containing 1
chr16_+_69984809 3.091 NM_182619
CLEC18C
CLEC18A
C-type lectin domain family 18, member C
C-type lectin domain family 18, member A
chr2_+_11682836 3.085 NM_033090
GREB1
growth regulation by estrogen in breast cancer 1
chr11_-_85469043 3.083 NM_001162951
NM_001162953
SYTL2

synaptotagmin-like 2

chr14_-_91526912 3.072 NM_004755
NM_182398
RPS6KA5

ribosomal protein S6 kinase, 90kDa, polypeptide 5

chr2_+_166428845 3.053 NM_024969
CSRNP3
cysteine-serine-rich nuclear protein 3
chr20_-_2821120 3.052 FAM113A
family with sequence similarity 113, member A
chr6_+_99872769 3.022


chr5_+_131705353 2.989 NM_003060
SLC22A5
solute carrier family 22 (organic cation/carnitine transporter), member 5
chr13_+_97999289 2.977


chr15_+_66994669 2.975 NM_005585
SMAD6
SMAD family member 6
chr1_-_149812733 2.972 NM_021059
NM_001005464
HIST2H3C
HIST2H3A
histone cluster 2, H3c
histone cluster 2, H3a
chr4_-_74904329 2.963 NM_002090
CXCL3
chemokine (C-X-C motif) ligand 3
chr19_-_49140569 2.963 NM_001352
DBP
D site of albumin promoter (albumin D-box) binding protein
chr2_+_203500211 2.958 FAM117B
family with sequence similarity 117, member B
chrX_-_48828250 2.949 NM_004979
KCND1
potassium voltage-gated channel, Shal-related subfamily, member 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.42 2.44e-06 GO:0032502 developmental process
1.47 3.16e-06 GO:0048856 anatomical structure development
1.44 3.40e-06 GO:0007275 multicellular organismal development
1.49 6.01e-06 GO:0048731 system development
1.71 1.31e-05 GO:0009653 anatomical structure morphogenesis
1.86 4.60e-04 GO:0009888 tissue development
1.50 9.92e-04 GO:0030154 cell differentiation
1.48 1.68e-03 GO:0048869 cellular developmental process
2.00 1.77e-03 GO:0009887 organ morphogenesis
2.14 2.23e-03 GO:0048646 anatomical structure formation involved in morphogenesis
1.73 3.29e-03 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.48 6.78e-03 GO:0048513 organ development
2.32 2.18e-02 GO:0001944 vasculature development
4.01 3.06e-02 GO:0042472 inner ear morphogenesis
1.17 3.44e-02 GO:0050789 regulation of biological process
2.79 3.74e-02 GO:0048511 rhythmic process
1.18 4.22e-02 GO:0050794 regulation of cellular process
3.65 4.56e-02 GO:0042471 ear morphogenesis
1.96 4.95e-02 GO:0072358 cardiovascular system development
1.96 4.95e-02 GO:0072359 circulatory system development

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
3.68 4.72e-02 GO:0000786 nucleosome

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
2.03 1.17e-08 GO:0001071 nucleic acid binding transcription factor activity
2.03 1.17e-08 GO:0003700 sequence-specific DNA binding transcription factor activity
2.03 1.74e-05 GO:0043565 sequence-specific DNA binding
1.69 1.13e-03 GO:0030528 transcription regulator activity