Motif ID: JUN.p2

Z-value: 1.336


Transcription factors associated with JUN.p2:

Gene SymbolEntrez IDGene Name
JUN 3725 jun oncogene
JUNB 3726 jun B proto-oncogene
JUND 3727 jun D proto-oncogene

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
JUNBhg19_v1_chr19_+_12902295_129023320.681.4e-11Click!
JUNhg19_v1_chr1_-_59249687_592497840.652.8e-10Click!
JUNDhg19_v1_chr19_-_18392436_183925000.352.2e-03Click!


Activity profile for motif JUN.p2.

activity profile for motif JUN.p2


Sorted Z-values histogram for motif JUN.p2

Sorted Z-values for motif JUN.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of JUN.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_45971249 28.331 NM_001114171
NM_006732
FOSB

FBJ murine osteosarcoma viral oncogene homolog B

chr10_-_64576123 15.940 NM_000399
NM_001136177
NM_001136179
EGR2


early growth response 2


chr10_-_64576074 15.627 EGR2
early growth response 2
chr1_+_212782103 12.053 ATF3
activating transcription factor 3
chr8_-_22550708 9.854 NM_004430
EGR3
early growth response 3
chr2_-_73520448 9.601 NM_001965
EGR4
early growth response 4
chr2_-_224467049 9.223 SCG2
secretogranin II
chr5_-_172198160 8.618 NM_004417
DUSP1
dual specificity phosphatase 1
chr16_+_56225250 8.555 NM_020988
NM_138736
GNAO1

guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O

chr16_-_79634610 8.143 NM_001031804
NM_005360
MAF

v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)

chr19_+_1753661 7.953 NM_001080488
ONECUT3
one cut homeobox 3
chr7_+_28448970 7.878 LOC401317
uncharacterized LOC401317
chr2_-_224467095 7.690 SCG2
secretogranin II
chr5_-_132948222 7.546 NM_015082
FSTL4
follistatin-like 4
chr1_+_212738675 7.342 NM_001030287
ATF3
activating transcription factor 3
chr16_+_56225301 7.311 GNAO1
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
chr11_-_119234859 7.298 NM_171997
USP2
ubiquitin specific peptidase 2
chr11_-_1593149 7.126 NM_004420
DUSP8
dual specificity phosphatase 8
chr9_+_102584136 7.003 NM_006981
NM_173199
NM_173200
NR4A3


nuclear receptor subfamily 4, group A, member 3


chr21_-_44846927 6.912 NM_173354
SIK1
salt-inducible kinase 1
chr2_-_224467142 6.670 NM_003469
SCG2
secretogranin II
chr1_-_59249687 6.531 NM_002228
JUN
jun proto-oncogene
chr19_-_39402797 6.486 NM_001243212
LOC643669
uncharacterized LOC643669
chr11_-_119234628 5.900 USP2
ubiquitin specific peptidase 2
chr1_-_162346579 5.855 NM_182581
C1orf111
chromosome 1 open reading frame 111
chr22_-_44258210 5.831 NM_014351
SULT4A1
sulfotransferase family 4A, member 1
chr19_+_46733008 5.827 NM_198541
IGFL1
IGF-like family member 1
chr1_-_16482426 5.669 NM_004431
EPHA2
EPH receptor A2
chr19_+_49375638 5.355 NM_014330
PPP1R15A
protein phosphatase 1, regulatory subunit 15A
chr19_+_49375677 5.340 PPP1R15A
protein phosphatase 1, regulatory subunit 15A
chr14_-_77494974 5.281 NM_024496
IRF2BPL
interferon regulatory factor 2 binding protein-like
chr19_+_49375679 5.267 PPP1R15A
protein phosphatase 1, regulatory subunit 15A
chr12_-_123380682 5.250 NM_024667
VPS37B
vacuolar protein sorting 37 homolog B (S. cerevisiae)
chr1_+_212781969 5.102 NM_001040619
NM_001206484
NM_001206488
NM_001674
ATF3



activating transcription factor 3



chr4_-_23891608 5.005 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr10_-_1779669 4.802 NM_018702
ADARB2
adenosine deaminase, RNA-specific, B2
chr1_+_152956563 4.742 NM_001199828
NM_005987
SPRR1A

small proline-rich protein 1A

chr10_+_5566923 4.734 NM_005185
CALML3
calmodulin-like 3
chr17_-_8055684 4.677 NM_002616
PER1
period homolog 1 (Drosophila)
chr19_+_13263890 4.618 IER2
immediate early response 2
chr5_+_137801166 4.604 EGR1
early growth response 1
chr20_+_43344005 4.499 WISP2
WNT1 inducible signaling pathway protein 2
chr22_+_38597938 4.493 NM_001161572
NM_001161574
NM_012323
MAFF


v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)


chr12_-_123380628 4.427 VPS37B
vacuolar protein sorting 37 homolog B (S. cerevisiae)
chr2_+_241375207 4.419 GPC1
glypican 1
chr10_+_123923104 4.307 NM_006997
NM_206860
TACC2

transforming, acidic coiled-coil containing protein 2

chr2_+_228678556 4.207 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr9_+_130860769 4.146 SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr22_+_38598065 4.121 MAFF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr10_+_123922940 4.038 TACC2
transforming, acidic coiled-coil containing protein 2
chr1_+_207039153 4.020 NM_018724
IL20
interleukin 20
chr19_-_52227220 3.941 NM_001523
HAS1
hyaluronan synthase 1
chr6_+_43211221 3.877 NM_032538
TTBK1
tau tubulin kinase 1
chr5_-_95768660 3.853 NM_000439
PCSK1
proprotein convertase subtilisin/kexin type 1
chr10_+_23983674 3.807 NM_001098500
KIAA1217
KIAA1217
chr5_-_132948195 3.727 FSTL4
follistatin-like 4
chr17_-_8059637 3.718 PER1
period homolog 1 (Drosophila)
chr5_+_137801178 3.639 NM_001964
EGR1
early growth response 1
chr2_-_157189040 3.523 NM_006186
NR4A2
nuclear receptor subfamily 4, group A, member 2
chr19_-_46088021 3.504 OPA3
optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
chr5_+_159343739 3.367 NM_000679
ADRA1B
adrenergic, alpha-1B-, receptor
chr16_+_71879858 3.362


chr2_+_11052062 3.360 NM_002236
KCNF1
potassium voltage-gated channel, subfamily F, member 1
chr19_+_18723666 3.304 NM_012109
TMEM59L
transmembrane protein 59-like
chr10_-_73848766 3.303 NM_001134434
NM_014767
SPOCK2

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2

chr12_-_13256572 3.188 NM_001080554
NM_001080555
NM_001206842
GSG1


germ cell associated 1


chr12_-_123380608 3.143


chr22_+_31518923 3.139 NM_001002837
INPP5J
inositol polyphosphate-5-phosphatase J
chr5_+_145317297 3.131 SH3RF2
SH3 domain containing ring finger 2
chr19_-_5340700 3.129 NM_002850
NM_130853
NM_130854
NM_130855
PTPRS



protein tyrosine phosphatase, receptor type, S



chr17_+_42385780 3.114 NM_001144825
NM_001144826
NM_006695
RUNDC3A


RUN domain containing 3A


chr5_-_57755787 3.095 NM_001252226
NM_006622
PLK2

polo-like kinase 2

chr19_-_9695166 3.083 NM_001008727
ZNF121
zinc finger protein 121
chr17_+_27071008 3.076 NM_004295
TRAF4
TNF receptor-associated factor 4
chr7_+_44646220 3.075 OGDH
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chr19_+_57901330 3.063 ZNF548
ZNF17
zinc finger protein 548
zinc finger protein 17
chr17_+_20224457 3.045 CCDC144C
coiled-coil domain containing 144C
chr2_+_28615695 3.044 FOSL2
FOS-like antigen 2
chr3_-_156877882 3.040 CCNL1
cyclin L1
chr9_+_130860816 3.033 NM_052901
NM_001006643
SLC25A25

solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25

chr11_-_119252364 3.020 NM_001243759
NM_004205
USP2

ubiquitin specific peptidase 2

chr20_+_43343884 3.007 NM_003881
WISP2
WNT1 inducible signaling pathway protein 2
chr6_-_7389941 2.987 NM_001170692
NM_001170693
NM_205864
CAGE1


cancer antigen 1


chr9_-_34397786 2.964 NM_032596
C9orf24
chromosome 9 open reading frame 24
chr11_-_2193015 2.963 NM_000360
NM_199292
NM_199293
TH


tyrosine hydroxylase


chr7_+_44646189 2.940 OGDH
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chr2_+_74781511 2.938 NM_001381
DOK1
docking protein 1, 62kDa (downstream of tyrosine kinase 1)
chr10_-_99446899 2.934 NM_021732
AVPI1
arginine vasopressin-induced 1
chr19_-_4902878 2.900 NM_001080523
ARRDC5
arrestin domain containing 5
chr7_+_44646168 2.879 OGDH
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chr9_+_132251323 2.869 LOC100506190
uncharacterized LOC100506190
chr19_-_9731883 2.868 NM_152289
ZNF561
zinc finger protein 561
chr10_-_128209996 2.852 NM_001004298
C10orf90
chromosome 10 open reading frame 90
chr10_+_101542460 2.822 NM_000392
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr3_+_89156804 2.814 EPHA3
EPH receptor A3
chr16_+_71879893 2.791 NM_001137675
ATXN1L
ataxin 1-like
chr2_+_28615771 2.771 NM_005253
FOSL2
FOS-like antigen 2
chr9_+_130830595 2.751 SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr14_-_77494621 2.748 IRF2BPL
interferon regulatory factor 2 binding protein-like
chr7_+_44646197 2.718 OGDH
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chr17_+_53342320 2.716 NM_002126
HLF
hepatic leukemia factor
chr9_+_130830447 2.682 NM_001006641
SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr21_-_35899046 2.670 NM_203418
RCAN1
regulator of calcineurin 1
chr19_-_2702738 2.611 NM_052847
GNG7
guanine nucleotide binding protein (G protein), gamma 7
chr19_-_48018277 2.600 NAPA
N-ethylmaleimide-sensitive factor attachment protein, alpha
chr12_+_86268072 2.574 NM_006183
NTS
neurotensin
chr17_+_71161110 2.558 NM_001050
SSTR2
somatostatin receptor 2
chr12_-_12715244 2.547 NM_030640
DUSP16
dual specificity phosphatase 16
chr10_-_73848530 2.518 NM_001244950
SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr11_+_24518515 2.516 NM_001009909
NM_001252008
NM_001252010
LUZP2


leucine zipper protein 2


chr19_-_49540072 2.511 NM_033377
CGB1
CGB2
chorionic gonadotropin, beta polypeptide 1
chorionic gonadotropin, beta polypeptide 2
chr7_+_128312345 2.504 NM_001012454
NM_001128926
FAM71F2

family with sequence similarity 71, member F2

chr20_+_33292117 2.475 NM_021202
TP53INP2
tumor protein p53 inducible nuclear protein 2
chr1_+_152974222 2.473 NM_001097589
NM_005416
SPRR3

small proline-rich protein 3

chr10_-_106093662 2.470 NM_033397
ITPRIP
inositol 1,4,5-trisphosphate receptor interacting protein
chr17_+_48046561 2.459 NM_138281
DLX4
distal-less homeobox 4
chr9_-_131644176 2.443 NM_001122671
NM_001122672
NM_004059
CCBL1


cysteine conjugate-beta lyase, cytoplasmic


chr19_-_48018163 2.442 NAPA
N-ethylmaleimide-sensitive factor attachment protein, alpha
chr9_-_33402505 2.436 NM_001170
AQP7
aquaporin 7
chr13_+_46276445 2.420 NM_152719
SPERT
spermatid associated
chr14_+_96722546 2.418 NM_000710
BDKRB1
bradykinin receptor B1
chr10_-_131762374 2.373 EBF3
early B-cell factor 3
chr6_-_26032287 2.352 NM_003537
HIST1H3B
histone cluster 1, H3b
chr2_-_27531113 2.327 NM_003353
UCN
urocortin
chr17_+_53342356 2.310 HLF
hepatic leukemia factor
chrX_+_83116153 2.309 NM_021118
CYLC1
cylicin, basic protein of sperm head cytoskeleton 1
chr19_+_45504686 2.304 NM_006509
RELB
v-rel reticuloendotheliosis viral oncogene homolog B
chr15_-_72612497 2.296 NM_052840
CELF6
CUGBP, Elav-like family member 6
chr18_-_77439739 2.293 FLJ25715
uncharacterized protein FLJ25715
chr20_+_55099784 2.291 NM_001012971
FAM209A
FAM209B
family with sequence similarity 209, member A
family with sequence similarity 209, member B
chr10_-_106098161 2.274 ITPRIP
inositol 1,4,5-trisphosphate receptor interacting protein
chr1_+_45266035 2.261 NM_004073
PLK3
polo-like kinase 3
chr1_-_161039745 2.252 NM_001025598
NM_181720
ARHGAP30

Rho GTPase activating protein 30

chr11_-_119252267 2.243 USP2
ubiquitin specific peptidase 2
chr7_+_44646180 2.238 OGDH
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chr14_-_69259654 2.236 ZFP36L1
zinc finger protein 36, C3H type-like 1
chr19_+_54960380 2.234 LENG8
leukocyte receptor cluster (LRC) member 8
chr2_-_134326030 2.220 NM_207363
NM_207481
NCKAP5

NCK-associated protein 5

chr20_+_17207596 2.217 NM_001201529
NM_002594
PCSK2

proprotein convertase subtilisin/kexin type 2

chr19_-_2702662 2.209 GNG7
guanine nucleotide binding protein (G protein), gamma 7
chr5_-_138211054 2.206 NM_015564
LRRTM2
leucine rich repeat transmembrane neuronal 2
chr1_-_76076762 2.169 NM_001130058
NM_152697
SLC44A5

solute carrier family 44, member 5

chr3_+_89156673 2.162 NM_005233
NM_182644
EPHA3

EPH receptor A3

chr22_+_50528307 2.161 NM_001164104
NM_018995
MOV10L1

Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse)

chr19_-_46088084 2.155 NM_001017989
NM_025136
OPA3

optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)

chr9_-_73028278 2.154 KLF9
Kruppel-like factor 9
chr15_+_31619043 2.150 NM_015995
KLF13
Kruppel-like factor 13
chr18_+_13218777 2.149 NM_181481
NM_181482
C18orf1

chromosome 18 open reading frame 1

chr9_+_132251403 2.147 LOC100506190
uncharacterized LOC100506190
chr6_-_166401526 2.136 LINC00473
long intergenic non-protein coding RNA 473
chr20_+_32250089 2.135 NM_080825
C20orf144
chromosome 20 open reading frame 144
chr4_+_145567147 2.120 NM_022475
HHIP
hedgehog interacting protein
chr22_+_21771661 2.099 NM_015094
HIC2
hypermethylated in cancer 2
chr2_+_211458078 2.085 NM_001122634
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr7_+_73245192 2.084 NM_001305
CLDN4
claudin 4
chr14_+_93389491 2.075 CHGA
chromogranin A (parathyroid secretory protein 1)
chr8_-_29207795 2.057 NM_001394
DUSP4
dual specificity phosphatase 4
chr20_+_10199455 2.018 NM_003081
NM_130811
SNAP25

synaptosomal-associated protein, 25kDa

chr20_-_39317875 2.018 NM_005461
MAFB
v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)
chr19_-_46088074 2.011 OPA3
optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
chr17_-_77813049 2.007 NM_003655
CBX4
chromobox homolog 4
chr1_+_9599520 2.005 NM_032315
SLC25A33
solute carrier family 25, member 33
chr6_-_27782517 2.005 NM_021066
HIST1H2AJ
histone cluster 1, H2aj
chr16_+_86544104 2.004 NM_001451
FOXF1
forkhead box F1
chr1_+_9599546 2.002 SLC25A33
solute carrier family 25, member 33
chr2_+_28615668 2.001 FOSL2
FOS-like antigen 2
chr12_+_104359557 1.999 NM_003211
TDG
thymine-DNA glycosylase
chr5_-_112770537 1.991 NM_032028
TSSK1B
testis-specific serine kinase 1B
chr2_-_157186681 1.988 NR4A2
nuclear receptor subfamily 4, group A, member 2
chr15_+_78556901 1.952 NM_001130182
DNAJA4
DnaJ (Hsp40) homolog, subfamily A, member 4
chr3_-_62359189 1.952 NM_018008
FEZF2
FEZ family zinc finger 2
chr8_+_126442557 1.948 NM_025195
TRIB1
tribbles homolog 1 (Drosophila)
chr19_+_49109999 1.948 NM_133498
SPACA4
sperm acrosome associated 4
chr14_-_69260630 1.925 NM_001244698
NM_004926
ZFP36L1

zinc finger protein 36, C3H type-like 1

chr16_+_69139466 1.925 NM_001199280
HAS3
hyaluronan synthase 3
chrX_+_110339374 1.923 NM_002578
PAK3
p21 protein (Cdc42/Rac)-activated kinase 3
chr7_+_44646120 1.893 NM_001003941
NM_001165036
NM_002541
OGDH


oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)


chr9_+_105757592 1.890 NM_001340
CYLC2
cylicin, basic protein of sperm head cytoskeleton 2
chr8_-_95274520 1.879 GEM
GTP binding protein overexpressed in skeletal muscle
chr19_-_55628780 1.877 NM_017607
PPP1R12C
protein phosphatase 1, regulatory subunit 12C
chr19_+_54960064 1.874 NM_052925
LENG8
leukocyte receptor cluster (LRC) member 8
chr15_-_72612127 1.871 CELF6
CUGBP, Elav-like family member 6
chr15_-_72612469 1.859 CELF6
CUGBP, Elav-like family member 6
chr1_-_217113007 1.852 NM_001243512
NM_001243513
NM_001243510
NM_001243511
ESRRG



estrogen-related receptor gamma



chr17_-_8661876 1.833 NM_001128076
SPDYE4
speedy homolog E4 (Xenopus laevis)
chr1_+_45265896 1.830 PLK3
polo-like kinase 3
chr1_-_161039413 1.813 ARHGAP30
Rho GTPase activating protein 30
chr8_-_95274540 1.810 NM_005261
NM_181702
GEM

GTP binding protein overexpressed in skeletal muscle

chr17_+_48585744 1.807 NM_032133
MYCBPAP
MYCBP associated protein
chr1_+_45266048 1.805 PLK3
polo-like kinase 3
chr20_-_44600939 1.799 ZNF335
zinc finger protein 335
chr19_-_57352055 1.788 NM_001146326
NM_001146327
NM_015363
NM_001146184
NM_001146185
NM_001146187
NM_006210
ZIM2


PEG3



zinc finger, imprinted 2


paternally expressed 3



chr11_+_65658101 1.787 CCDC85B
coiled-coil domain containing 85B
chr1_-_161039703 1.786 ARHGAP30
Rho GTPase activating protein 30
chr17_-_40828441 1.784 NM_024927
PLEKHH3
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chr9_-_19033183 1.779 NM_153707
FAM154A
family with sequence similarity 154, member A
chr2_-_28113954 1.777 LOC100302650
uncharacterized LOC100302650
chrX_+_9431314 1.771 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr1_-_161039649 1.763 ARHGAP30
Rho GTPase activating protein 30
chr8_-_101322245 1.750 NM_183419
RNF19A
ring finger protein 19A

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.87 3.44e-07 GO:0007275 multicellular organismal development
1.79 8.98e-07 GO:0032502 developmental process
1.76 1.46e-05 GO:0080090 regulation of primary metabolic process
1.74 2.89e-05 GO:0031323 regulation of cellular metabolic process
1.78 8.16e-05 GO:0048856 anatomical structure development
1.87 8.17e-05 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.92 9.68e-05 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.96 1.00e-04 GO:0051252 regulation of RNA metabolic process
1.54 1.01e-04 GO:0032501 multicellular organismal process
2.61 1.08e-04 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.97 1.35e-04 GO:0006355 regulation of transcription, DNA-dependent
1.84 1.82e-04 GO:0031326 regulation of cellular biosynthetic process
1.81 1.97e-04 GO:0048731 system development
1.72 2.61e-04 GO:0060255 regulation of macromolecule metabolic process
1.87 2.64e-04 GO:0010556 regulation of macromolecule biosynthetic process
1.81 2.72e-04 GO:0051171 regulation of nitrogen compound metabolic process
4.10 2.79e-04 GO:0007610 behavior
1.82 2.82e-04 GO:0009889 regulation of biosynthetic process
1.82 7.88e-04 GO:0010468 regulation of gene expression
1.37 1.30e-03 GO:0050789 regulation of biological process
1.60 1.36e-03 GO:0019222 regulation of metabolic process
6.39 1.47e-03 GO:0007611 learning or memory
1.33 3.11e-03 GO:0065007 biological regulation
5.84 3.57e-03 GO:0050890 cognition
1.91 4.67e-03 GO:0048513 organ development
1.36 6.07e-03 GO:0050794 regulation of cellular process
2.10 1.12e-02 GO:0051239 regulation of multicellular organismal process
7.91 3.25e-02 GO:0007612 learning
1.52 4.09e-02 GO:0023052 signaling

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
2.88 8.84e-08 GO:0001071 nucleic acid binding transcription factor activity
2.88 8.84e-08 GO:0003700 sequence-specific DNA binding transcription factor activity
3.09 3.64e-06 GO:0043565 sequence-specific DNA binding
1.94 9.49e-06 GO:0003677 DNA binding
2.29 1.04e-03 GO:0030528 transcription regulator activity
19.11 9.57e-03 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity
17.74 1.32e-02 GO:0033549 MAP kinase phosphatase activity
1.53 1.49e-02 GO:0003676 nucleic acid binding
3.03 3.46e-02 GO:0016563 transcription activator activity