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Motif ID: IRF1,2,7.p3

Z-value: 3.050

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr1_+_79086087	55.236	NM_006820	IFI44L	interferon-induced protein 44-like
chr19_-_17516383	44.348	NM_004335	BST2	bone marrow stromal cell antigen 2
chr11_+_113931228	36.459	NM_001018011	ZBTB16	zinc finger and BTB domain containing 16
chr6_+_31913852	34.685		CFB	complement factor B
chr2_-_47918413	33.752		RPL18A	ribosomal protein L18a
chr20_-_48099178	33.698	NM_004975	KCNB1	potassium voltage-gated channel, Shab-related subfamily, member 1
chr4_-_76944585	33.260	NM_001565	CXCL10	chemokine (C-X-C motif) ligand 10
chr10_+_91087601	33.021	NM_001549	IFIT3	interferon-induced protein with tetratricopeptide repeats 3
chr10_+_91152321	32.761	NM_001548	IFIT1	interferon-induced protein with tetratricopeptide repeats 1
chr10_+_91092238	31.405	NM_001031683	IFIT3	interferon-induced protein with tetratricopeptide repeats 3
chr6_+_31913708	30.951	NM_001710	CFB	complement factor B
chr6_+_31913763	26.818		CFB	complement factor B
chr13_-_43566301	25.352	NM_001002264 NM_033255	EPSTI1	epithelial stromal interaction 1 (breast)
chr10_-_5045967	24.750	NM_001135241	AKR1C2	aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
chr10_+_91061705	24.706	NM_001547	IFIT2	interferon-induced protein with tetratricopeptide repeats 2
chr22_+_36044412	24.577	NM_030641	APOL6	apolipoprotein L, 6
chr11_+_63304272	24.507	NM_004585	RARRES3	retinoic acid receptor responder (tazarotene induced) 3
chr11_-_18270167	23.256	NM_001199744 NM_001127380 NM_030754	SAA2-SAA4 SAA2	SAA2-SAA4 readthrough serum amyloid A2
chr22_+_36649172	21.324		APOL1	apolipoprotein L, 1
chr6_+_126240369	20.860	NM_001199622	NCOA7	nuclear receptor coactivator 7
chr22_+_36649116	19.681	NM_001136540 NM_001136541 NM_003661 NM_145343	APOL1	apolipoprotein L, 1
chr2_-_192711923	19.614	NM_004657	SDPR	serum deprivation response
chr5_+_131746579	19.420		C5orf56	chromosome 5 open reading frame 56
chr1_+_948846	19.280	NM_005101	ISG15	ISG15 ubiquitin-like modifier
chr3_-_172241060	18.636	NM_001190943 NM_001190942 NM_003810	TNFSF10	tumor necrosis factor (ligand) superfamily, member 10
chr22_-_36556781	18.259	NM_145640	APOL3	apolipoprotein L, 3
chr19_-_47735858	17.622	NM_001127240 NM_001127241 NM_001127242	BBC3	BCL2 binding component 3
chr10_+_101542554	17.523		ABCC2	ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr4_-_169239816	17.421	NM_017631	DDX60	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr17_-_67138013	17.025	NM_080284	ABCA6	ATP-binding cassette, sub-family A (ABC1), member 6
chr10_+_5005685	16.960		AKR1C1	aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr6_+_31913920	16.366		CFB	complement factor B
chr1_+_212788359	16.018	NM_001206486	ATF3	activating transcription factor 3
chr10_+_101542460	15.976	NM_000392	ABCC2	ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr6_+_26440699	15.775	NM_001242803 NM_006994 NM_197974	BTN3A3	butyrophilin, subfamily 3, member A3
chr13_+_31309644	15.469	NM_001629	ALOX5AP	arachidonate 5-lipoxygenase-activating protein
chr10_+_5005453	15.254	NM_001353	AKR1C1	aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr22_+_36044475	15.146		APOL6	apolipoprotein L, 6
chr10_+_5005601	14.310		AKR1C1 AKR1C3	aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr13_+_31309690	14.023		ALOX5AP	arachidonate 5-lipoxygenase-activating protein
chr4_+_89300110	13.800		HERC6	hect domain and RLD 6
chr14_-_107218786	13.649		IGHA1 IGHG1 IGHM	immunoglobulin heavy constant alpha 1 immunoglobulin heavy constant gamma 1 (G1m marker) immunoglobulin heavy constant mu
chr17_-_67240955	12.984	NM_080282	ABCA10	ATP-binding cassette, sub-family A (ABC1), member 10
chr6_+_26402464	12.958	NM_001145008 NM_001145009 NM_007048 NM_194441	BTN3A1	butyrophilin, subfamily 3, member A1
chr1_+_79115476	12.933	NM_006417	IFI44	interferon-induced protein 44
chr4_+_186990308	12.878	NM_003265	TLR3	toll-like receptor 3
chr14_+_94577078	12.761	NM_001130080 NM_005532	IFI27	interferon, alpha-inducible protein 27
chr19_-_50400131	12.710	NM_152899	IL4I1	interleukin 4 induced 1
chr4_+_142557722	12.514	NM_000585 NM_172175	IL15	interleukin 15
chr19_-_39368889	12.513	NM_001195833 NM_198445	RINL	Ras and Rab interactor-like
chr2_+_85811530	12.465	NM_006634	VAMP5	vesicle-associated membrane protein 5 (myobrevin)
chr13_-_30423599	12.248		UBL3	ubiquitin-like 3
chr4_-_122148620	12.157	NM_001244764	TNIP3	TNFAIP3 interacting protein 3
chr4_+_41614725	11.973		LIMCH1	LIM and calponin homology domains 1
chr11_+_5710816	11.660	NM_001199573 NM_006074	TRIM22	tripartite motif containing 22
chr7_-_122526410	11.658		CADPS2	Ca++-dependent secretion activator 2
chr1_+_158901336	11.575	NM_152501 NM_198928 NM_198929 NM_198930	PYHIN1	pyrin and HIN domain family, member 1
chr11_-_63330854	11.405	NM_017878	HRASLS2	HRAS-like suppressor 2
chr2_-_101767714	11.170	NM_001102426	TBC1D8	TBC1 domain family, member 8 (with GRAM domain)
chr6_-_138189313	10.969
chr1_-_27998700	10.587		IFI6	interferon, alpha-inducible protein 6
chr12_-_53298765	10.409	NM_002273	KRT8	keratin 8
chr2_-_152146133	10.385		NMI	N-myc (and STAT) interactor
chr11_+_114167197	10.371		NNMT	nicotinamide N-methyltransferase
chr18_-_65182507	10.365		DSEL	dermatan sulfate epimerase-like
chr5_+_42565963	10.240	NM_001242460 NM_001242461 NM_001242462	GHR	growth hormone receptor
chr5_-_95158465	9.905	NM_001118890 NM_001243658 NM_001243659 NM_002064	GLRX	glutaredoxin (thioltransferase)
chr1_-_27998719	9.878	NM_002038 NM_022872 NM_022873	IFI6	interferon, alpha-inducible protein 6
chr11_+_114167168	9.822		NNMT	nicotinamide N-methyltransferase
chr5_-_95158365	9.771		GLRX	glutaredoxin (thioltransferase)
chr7_-_122526781	9.749	NM_001009571 NM_001167940 NM_017954	CADPS2	Ca++-dependent secretion activator 2
chr2_+_143635225	9.701		KYNU	kynureninase
chr11_-_320775	9.648	NM_021034	IFITM3	interferon induced transmembrane protein 3
chr9_-_123812535	9.619	NM_001735	C5	complement component 5
chr10_+_70847857	9.598		SRGN	serglycin
chr6_-_137366100	9.518	NM_014432	IL20RA	interleukin 20 receptor, alpha
chr18_+_55816546	9.452	NM_001144965 NM_001144968 NM_001144969 NM_001144971	NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like
chr11_+_20044362	9.429		NAV2	neuron navigator 2
chr14_+_91580967	9.428	NM_001102367	C14orf159	chromosome 14 open reading frame 159
chr22_-_36635552	9.370		APOL2	apolipoprotein L, 2
chr8_-_145060594	9.366	NM_032789	PARP10	poly (ADP-ribose) polymerase family, member 10
chr1_+_110453456	9.273		CSF1	colony stimulating factor 1 (macrophage)
chr1_+_27668499	9.233		SYTL1	synaptotagmin-like 1
chr12_+_53442972	9.198		TENC1	tensin like C1 domain containing phosphatase (tensin 2)
chr16_-_67970734	9.174	NM_002801	PSMB10	proteasome (prosome, macropain) subunit, beta type, 10
chr2_-_152146373	9.165	NM_004688	NMI	N-myc (and STAT) interactor
chr13_-_34250899	9.097	NM_001243476	STARD13	StAR-related lipid transfer (START) domain containing 13
chr12_-_12715244	9.030	NM_030640	DUSP16	dual specificity phosphatase 16
chr11_-_320925	9.029		IFITM3	interferon induced transmembrane protein 3
chr1_+_27668462	8.996	NM_001193308 NM_032872	SYTL1	synaptotagmin-like 1
chr14_+_91580713	8.977		C14orf159	chromosome 14 open reading frame 159
chr6_+_31895401	8.861		C2	complement component 2
chr1_-_149908759	8.833	NM_001145862	MTMR11	myotubularin related protein 11
chr11_-_104916041	8.731	NM_001017534 NM_052889	CARD16	caspase recruitment domain family, member 16
chr6_-_32821592	8.718		TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chrX_+_102883647	8.615	NM_001006640	TCEAL1	transcription elongation factor A (SII)-like 1
chr13_-_30424795	8.570	NM_007106	UBL3	ubiquitin-like 3
chr1_-_149908721	8.499		MTMR11	myotubularin related protein 11
chr12_-_11002051	8.493	NM_001098538 NM_007244	PRR4	proline rich 4 (lacrimal)
chrX_+_102883891	8.446	NM_001006639 NM_004780	TCEAL1	transcription elongation factor A (SII)-like 1
chr6_-_32821412	8.413		TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr13_+_43148182	8.361	NM_003701	TNFSF11	tumor necrosis factor (ligand) superfamily, member 11
chr3_+_51977286	8.359		PARP3	poly (ADP-ribose) polymerase family, member 3
chr3_-_49851217	8.303		UBA7	ubiquitin-like modifier activating enzyme 7
chr6_-_33282006	8.296	NM_003190 NM_172208 NM_172209	TAPBP	TAP binding protein (tapasin)
chr15_-_74502045	8.213	NM_001199040	STRA6	stimulated by retinoic acid gene 6 homolog (mouse)
chr10_+_5238756	8.202	NM_001818	AKR1C4	aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
chr8_-_145060563	8.193		PARP10	poly (ADP-ribose) polymerase family, member 10
chr17_-_80291639	8.176		SECTM1	secreted and transmembrane 1
chr1_-_27998658	8.172		IFI6	interferon, alpha-inducible protein 6
chr1_+_110453232	8.135	NM_000757 NM_172210 NM_172212	CSF1	colony stimulating factor 1 (macrophage)
chr11_+_18287807	8.134	NM_000331 NM_001178006 NM_199161	SAA1	serum amyloid A1
chr17_-_67057046	8.056	NM_080283	ABCA9	ATP-binding cassette, sub-family A (ABC1), member 9
chr6_-_32821743	8.056	NM_000593	TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr19_+_44669214	8.035	NM_001146220 NM_001032373 NM_001032374 NM_015919 NM_001032372	ZNF226	zinc finger protein 226
chr1_+_120254418	7.942	NM_006623	PHGDH	phosphoglycerate dehydrogenase
chr2_-_192711651	7.940		SDPR	serum deprivation response
chr12_+_113376001	7.809		OAS3	2'-5'-oligoadenylate synthetase 3, 100kDa
chr2_+_28616346	7.764		FOSL2	FOS-like antigen 2
chr17_-_80291610	7.741		SECTM1	secreted and transmembrane 1
chr17_+_9745847	7.694		GLP2R	glucagon-like peptide 2 receptor
chr6_+_32821924	7.668	NM_002800	PSMB9	proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)
chr5_+_96212167	7.625		ERAP2	endoplasmic reticulum aminopeptidase 2
chr4_-_156874993	7.528	NM_001334	CTSO	cathepsin O
chr6_-_33281847	7.521		TAPBP	TAP binding protein (tapasin)
chr3_-_187452669	7.493	NM_001134738	BCL6	B-cell CLL/lymphoma 6
chr7_+_150382783	7.477	NM_015660	GIMAP2	GTPase, IMAP family member 2
chr16_-_67970651	7.348		PSMB10	proteasome (prosome, macropain) subunit, beta type, 10
chr19_+_17516502	7.325		LOC100507535	uncharacterized LOC100507535
chr17_+_25958217	7.263		LGALS9	lectin, galactoside-binding, soluble, 9
chr14_+_91580467	7.218		C14orf159	chromosome 14 open reading frame 159
chr6_-_33281790	7.202		TAPBP	TAP binding protein (tapasin)
chr11_+_34642651	7.187		EHF	ets homologous factor
chr3_+_159706622	7.151	NM_000882	IL12A	interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
chr17_+_48348766	7.130	NM_001168215	TMEM92	transmembrane protein 92
chr2_+_28616360	7.061		FOSL2	FOS-like antigen 2
chr3_+_51976274	7.043	NM_001003931 NM_005485	PARP3	poly (ADP-ribose) polymerase family, member 3
chr11_+_10482677	7.043	NM_001172430	AMPD3	adenosine monophosphate deaminase 3
chr9_-_32526164	6.977	NM_014314	DDX58	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr9_-_95298251	6.975	NM_001197295 NM_001197296 NM_001393	ECM2	extracellular matrix protein 2, female organ and adipocyte specific
chr13_+_39612440	6.960	NM_001012754 NM_001017370	NHLRC3	NHL repeat containing 3
chr17_-_15586192	6.945	NM_006470	TRIM16	tripartite motif containing 16
chr6_-_137365811	6.920		IL20RA	interleukin 20 receptor, alpha
chr13_+_50070096	6.908		PHF11	PHD finger protein 11
chr12_+_113376301	6.899		OAS3	2'-5'-oligoadenylate synthetase 3, 100kDa
chr2_-_163174816	6.861	NM_022168	IFIH1	interferon induced with helicase C domain 1
chr12_-_54778456	6.826	NM_015481	ZNF385A	zinc finger protein 385A
chr3_-_28390506	6.817	NM_001134432 NM_001134433 NM_022461	AZI2	5-azacytidine induced 2
chr10_+_63808968	6.794	NM_001244638	ARID5B	AT rich interactive domain 5B (MRF1-like)
chr21_+_34144410	6.794		C21orf49	chromosome 21 open reading frame 49
chr3_-_49851356	6.766	NM_003335	UBA7	ubiquitin-like modifier activating enzyme 7
chr19_-_6442004	6.611		SLC25A23	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
chr3_-_28390280	6.567		AZI2	5-azacytidine induced 2
chr6_-_87804773	6.555	NM_000735 NM_001252383	CGA	glycoprotein hormones, alpha polypeptide
chrX_-_15620191	6.538	NM_021804	ACE2	angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr20_+_1246959	6.518	NM_014723	SNPH	syntaphilin
chr7_-_99277518	6.513	NM_000777 NM_001190484	CYP3A5	cytochrome P450, family 3, subfamily A, polypeptide 5
chr17_-_48945338	6.446	NM_001243877	TOB1	transducer of ERBB2, 1
chr13_+_50070527	6.430	NM_001040444	PHF11	PHD finger protein 11
chr4_-_169401603	6.426	NM_001012967	DDX60L	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like
chr2_-_231084600	6.419	NM_004509 NM_004510 NM_080424	SP110	SP110 nuclear body protein
chr4_+_130014828	6.353	NM_173487	C4orf33	chromosome 4 open reading frame 33
chr12_+_102271082	6.294	NM_018370	DRAM1	DNA-damage regulated autophagy modulator 1
chr1_-_89530890	6.280	NM_002053	GBP1	guanylate binding protein 1, interferon-inducible
chr18_-_55253785	6.266	NM_000140 NM_001012515	FECH	ferrochelatase
chr8_+_143808593	6.257	NM_016647	C8orf55	chromosome 8 open reading frame 55
chr1_+_174843523	6.213	NM_001243763	RABGAP1L	RAB GTPase activating protein 1-like
chr6_+_29759682	6.168	NM_001207043	LOC554223	histocompatibility antigen-related
chr17_+_41363845	6.164	NM_145041	TMEM106A	transmembrane protein 106A
chr4_+_77135192	6.117	NM_001242936	FAM47E	family with sequence similarity 47, member E
chr17_-_38520941	6.115	NM_152219	GJD3	gap junction protein, delta 3, 31.9kDa
chr1_+_210502188	6.080	NM_001170587 NM_001170588 NM_018194	HHAT	hedgehog acyltransferase
chr11_+_34642587	6.078	NM_001206615 NM_012153	EHF	ets homologous factor
chr12_+_94542239	6.064	NM_005761	PLXNC1	plexin C1
chr21_+_42792441	6.012	NM_001144925	MX1	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr6_+_25963398	5.991		TRIM38	tripartite motif containing 38
chr19_+_49977465	5.985	NM_001204502 NM_001459	FLT3LG	fms-related tyrosine kinase 3 ligand
chr4_+_87928083	5.927	NM_005935	AFF1	AF4/FMR2 family, member 1
chr8_+_18079176	5.921	NM_001160174	NAT1	N-acetyltransferase 1 (arylamine N-acetyltransferase)
chr10_-_102279590	5.853	NM_015490	SEC31B	SEC31 homolog B (S. cerevisiae)
chr20_-_45976626	5.852		ZMYND8	zinc finger, MYND-type containing 8
chr4_-_89744154	5.813	NM_001015045	FAM13A	family with sequence similarity 13, member A
chr1_-_24469571	5.755	NM_021258	IL22RA1	interleukin 22 receptor, alpha 1
chr3_+_122399665	5.725	NM_017554	PARP14	poly (ADP-ribose) polymerase family, member 14
chr19_+_54376975	5.703		MYADM	myeloid-associated differentiation marker
chr11_-_18343670	5.675	NM_007216 NM_181507 NM_181508	HPS5	Hermansky-Pudlak syndrome 5
chrX_+_37639306	5.650		CYBB	cytochrome b-245, beta polypeptide
chr3_-_145968819	5.521		PLSCR4	phospholipid scramblase 4
chr3_+_122283139	5.517	NM_138287	DTX3L	deltex 3-like (Drosophila)
chr2_-_228028765	5.456		COL4A4	collagen, type IV, alpha 4
chr14_-_23284565	5.447		SLC7A7	solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr15_+_63050761	5.446		TLN2	talin 2
chr2_+_210444154	5.432		MAP2	microtubule-associated protein 2
chr6_-_11382501	5.413	NM_001142393	NEDD9	neural precursor cell expressed, developmentally down-regulated 9
chr22_-_36635666	5.398	NM_030882	APOL2	apolipoprotein L, 2
chr2_+_61389628	5.362	NM_001143959	C2orf74	chromosome 2 open reading frame 74
chr6_-_32811773	5.335	NM_148919	PSMB8	proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr8_+_21916685	5.238	NM_001114138 NM_001978	EPB49	erythrocyte membrane protein band 4.9 (dematin)
chr22_+_39493228	5.219	NM_001166002 NM_001166003 NM_001166004 NM_181773	APOBEC3H	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H
chr1_+_9415944	5.214

Gene overrepresentation in process category:

Enrichment	P-value	GO Accession	GO Term
3.22	2.26e-13	GO:0006955	immune response
2.63	2.98e-13	GO:0002376	immune system process
4.37	5.10e-13	GO:0045087	innate immune response
10.50	1.03e-11	GO:0034340	response to type I interferon
10.11	1.12e-10	GO:0060337	type I interferon-mediated signaling pathway
10.11	1.12e-10	GO:0071357	cellular response to type I interferon
2.78	1.45e-09	GO:0006952	defense response
5.69	2.59e-09	GO:0009615	response to virus
4.92	2.83e-08	GO:0019221	cytokine-mediated signaling pathway
3.94	5.70e-08	GO:0034097	response to cytokine stimulus
4.44	2.94e-07	GO:0071345	cellular response to cytokine stimulus
21.43	7.41e-07	GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
15.67	2.34e-06	GO:0048002	antigen processing and presentation of peptide antigen
1.71	1.52e-05	GO:0006950	response to stress
34.82	2.85e-05	GO:0002483	antigen processing and presentation of endogenous peptide antigen
34.82	2.85e-05	GO:0019885	antigen processing and presentation of endogenous peptide antigen via MHC class I
1.35	6.67e-05	GO:0050896	response to stimulus
2.20	1.71e-04	GO:0051704	multi-organism process
6.97	5.59e-04	GO:0019882	antigen processing and presentation
24.87	5.71e-04	GO:0019883	antigen processing and presentation of endogenous antigen
2.76	8.56e-04	GO:0051707	response to other organism
2.49	2.24e-03	GO:0009607	response to biotic stimulus
2.02	3.60e-03	GO:0070887	cellular response to chemical stimulus
2.21	8.79e-03	GO:0071310	cellular response to organic substance
2.60	2.09e-02	GO:0044419	interspecies interaction between organisms
1.37	2.59e-02	GO:0051716	cellular response to stimulus

Gene overrepresentation in compartment category:

Enrichment	P-value	GO Accession	GO Term
1.26	1.07e-05	GO:0005737	cytoplasm
1.30	4.77e-04	GO:0044444	cytoplasmic part

Gene overrepresentation in function category:

Enrichment	P-value	GO Accession	GO Term
34.82	2.43e-04	GO:0047023	androsterone dehydrogenase activity
8.71	1.71e-02	GO:0033764	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
26.12	3.33e-02	GO:0047115	trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
7.46	4.34e-02	GO:0016229	steroid dehydrogenase activity