Motif ID: IKZF2.p2

Z-value: 1.042


Transcription factors associated with IKZF2.p2:

Gene SymbolEntrez IDGene Name
IKZF2 22807 IKAROS family zinc finger 2 (Helios)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
IKZF2hg19_v1_chr2_-_214016332_2140163320.161.6e-01Click!


Activity profile for motif IKZF2.p2.

activity profile for motif IKZF2.p2


Sorted Z-values histogram for motif IKZF2.p2

Sorted Z-values for motif IKZF2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of IKZF2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_216246961 10.380 FN1
fibronectin 1
chr2_-_216245573 9.886 FN1
fibronectin 1
chrX_+_102632108 9.595 NM_014380
NGFRAP1
nerve growth factor receptor (TNFRSF16) associated protein 1
chr16_+_82660573 9.500 CDH13
cadherin 13, H-cadherin (heart)
chr16_+_82660390 9.158 NM_001220488
NM_001220489
NM_001220490
NM_001220491
NM_001220492
NM_001257
CDH13





cadherin 13, H-cadherin (heart)





chr15_+_25101697 9.058 NM_022805
SNRPN
small nuclear ribonucleoprotein polypeptide N
chr16_+_82660641 8.868 CDH13
cadherin 13, H-cadherin (heart)
chr2_-_127963342 8.175 NM_001001665
CYP27C1
cytochrome P450, family 27, subfamily C, polypeptide 1
chr5_-_151066445 8.116 SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chr1_+_111889194 6.944 NM_181643
C1orf88
chromosome 1 open reading frame 88
chr6_-_47009992 6.809 NM_025048
NM_153840
GPR110

G protein-coupled receptor 110

chr2_-_216259197 6.801 FN1
fibronectin 1
chr12_-_133532847 6.136 NM_183238
NM_001164715
ZNF605

zinc finger protein 605

chr1_+_154300275 5.545 NM_020452
ATP8B2
ATPase, class I, type 8B, member 2
chr2_-_216248184 5.211 FN1
fibronectin 1
chr9_-_85882093 4.967 NM_001244962
FRMD3
FERM domain containing 3
chr1_-_150738292 4.662 NM_001199739
NM_004079
CTSS

cathepsin S

chr5_+_140602914 4.601 NM_018934
PCDHB14
protocadherin beta 14
chr8_+_32579350 4.507 NM_001159996
NRG1
neuregulin 1
chr1_-_36565849 4.287 NM_005202
COL8A2
collagen, type VIII, alpha 2
chrX_+_102631267 4.170 NM_206915
NM_206917
NGFRAP1

nerve growth factor receptor (TNFRSF16) associated protein 1

chr2_-_216249682 4.157 FN1
fibronectin 1
chr1_-_110933635 3.979 SLC16A4
solute carrier family 16, member 4 (monocarboxylic acid transporter 5)
chr19_+_41281281 3.951 NM_006533
MIA
melanoma inhibitory activity
chr1_-_109399705 3.909 NM_152763
AKNAD1
AKNA domain containing 1
chr2_+_30454396 3.909 NM_030915
LBH
limb bud and heart development homolog (mouse)
chr1_-_110933683 3.750 NM_001201546
NM_001201547
NM_001201548
NM_001201549
NM_004696
SLC16A4




solute carrier family 16, member 4 (monocarboxylic acid transporter 5)




chr1_-_242612757 3.683 NM_001195811
NM_001195812
PLD5

phospholipase D family, member 5

chr15_-_40600025 3.608 PLCB2
phospholipase C, beta 2
chr10_-_95360959 3.584 NM_006744
RBP4
retinol binding protein 4, plasma
chr18_+_61554938 3.527 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr7_-_137028533 3.480 NM_002825
PTN
pleiotrophin
chr10_+_63422718 3.463 NM_173554
C10orf107
chromosome 10 open reading frame 107
chr14_+_51026742 3.398 NM_015915
NM_181598
ATL1

atlastin GTPase 1

chr15_-_40600118 3.385 NM_004573
PLCB2
phospholipase C, beta 2
chr3_-_74570262 3.354 NM_020872
CNTN3
contactin 3 (plasmacytoma associated)
chr5_+_140247767 3.279 NM_018902
NM_031861
PCDHA11

protocadherin alpha 11

chr1_-_205391180 3.199 NM_001001552
NM_001199050
NM_001199051
NM_001199052
LEMD1



LEM domain containing 1



chr5_+_140254930 3.180 NM_018903
NM_031864
PCDHA12

protocadherin alpha 12

chr2_+_191301020 3.136 MFSD6
major facilitator superfamily domain containing 6
chr11_+_123986103 3.101 NM_001130142
NM_014622
NM_198315
VWA5A


von Willebrand factor A domain containing 5A


chr2_+_102953716 3.092 NM_003856
IL1RL1
interleukin 1 receptor-like 1
chr5_+_68800003 3.014 NM_001205255
OCLN
occludin
chr2_-_216289936 3.003 FN1
fibronectin 1
chr13_-_38172862 2.980 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr7_-_83278478 2.928 NM_012431
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr4_+_124317884 2.927 NM_199327
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chrX_+_2670092 2.905 NM_001141919
NM_001141920
NM_175569
XGPY2
XG


Xg pseudogene, Y-linked 2
Xg blood group


chr3_-_197300193 2.886 NM_203315
BDH1
3-hydroxybutyrate dehydrogenase, type 1
chrX_+_135251454 2.883 NM_001159704
FHL1
four and a half LIM domains 1
chr4_-_186733372 2.877 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr1_+_183155173 2.862 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr2_-_163099877 2.849 NM_004460
FAP
fibroblast activation protein, alpha
chr19_-_43709692 2.842 NM_002780
NM_213633
PSG4

pregnancy specific beta-1-glycoprotein 4

chr14_+_51026853 2.818 ATL1
atlastin GTPase 1
chr9_+_5510544 2.791 NM_025239
PDCD1LG2
programmed cell death 1 ligand 2
chr1_+_87012758 2.784 NM_012128
CLCA4
chloride channel accessory 4
chr5_+_140180782 2.780 NM_018906
NM_031497
PCDHA3

protocadherin alpha 3

chr4_-_186577858 2.747 SORBS2
sorbin and SH3 domain containing 2
chr1_-_23521221 2.739 NM_000864
HTR1D
5-hydroxytryptamine (serotonin) receptor 1D
chrX_-_43741593 2.730 NM_000898
MAOB
monoamine oxidase B
chr1_+_183155393 2.725 LAMC2
laminin, gamma 2
chr7_-_156468369 2.679


chr1_+_183155361 2.664 LAMC2
laminin, gamma 2
chr15_+_25230199 2.600 PAR5
Prader-Willi/Angelman syndrome-5
chr12_-_91573264 2.595 NM_133503
DCN
decorin
chrX_+_102631408 2.583 NGFRAP1
nerve growth factor receptor (TNFRSF16) associated protein 1
chr11_-_58343308 2.561 NM_004811
LPXN
leupaxin
chr2_-_238322770 2.536 COL6A3
collagen, type VI, alpha 3
chr2_+_48796158 2.530 NM_172311
STON1-GTF2A1L
STON1-GTF2A1L readthrough
chr2_+_48807725 2.523 NM_001198594
STON1
STON1-GTF2A1L
stonin 1
STON1-GTF2A1L readthrough
chr19_+_37342552 2.511 NM_001242475
NM_001242476
ZNF345

zinc finger protein 345

chrX_-_135863033 2.495 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr16_+_55512801 2.490 NM_004530
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr21_+_39628869 2.475 NM_170736
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr7_-_83270746 2.464 NM_001178129
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr12_-_28124915 2.385 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr15_+_45722762 2.372 NM_032413
NM_197955
C15orf48

chromosome 15 open reading frame 48

chr1_-_178007057 2.366 LOC730102
quinone oxidoreductase-like protein 2 pseudogene
chr2_-_238322840 2.360 NM_004369
NM_057164
NM_057165
NM_057166
NM_057167
COL6A3




collagen, type VI, alpha 3




chr18_-_52625278 2.342 NM_001143829
CCDC68
coiled-coil domain containing 68
chr6_+_13925097 2.340 NM_001165032
NM_152737
RNF182

ring finger protein 182

chr4_-_146859960 2.328


chr5_+_140557370 2.322 NM_019120
PCDHB8
protocadherin beta 8
chr4_+_124320664 2.296 NM_005841
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr11_-_33890931 2.288 LMO2
LIM domain only 2 (rhombotin-like 1)
chr7_-_83824216 2.287 NM_006080
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr17_-_67138013 2.282 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr5_-_121412805 2.280 NM_001178102
LOX
lysyl oxidase
chr8_-_133772808 2.271 NM_001145153
NM_144649
TMEM71

transmembrane protein 71

chr9_-_85946875 2.231 NM_001244961
FRMD3
FERM domain containing 3
chr12_-_10605928 2.230 NM_002259
NM_007328
KLRC1

killer cell lectin-like receptor subfamily C, member 1

chr19_-_37663332 2.228 NM_199126
ZNF585A
zinc finger protein 585A
chrX_-_84634664 2.221 POF1B
premature ovarian failure, 1B
chrX_-_135863104 2.217 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr19_+_21579884 2.160 NM_001076678
NM_145326
NM_175910
ZNF493


zinc finger protein 493


chrX_-_84634742 2.136 NM_024921
POF1B
premature ovarian failure, 1B
chr11_-_58345593 2.135 NM_001143995
LPXN
leupaxin
chr5_+_140480056 2.131 NM_018937
PCDHB3
protocadherin beta 3
chrX_+_105937067 2.104 NM_024539
RNF128
ring finger protein 128
chr7_+_93551015 2.100 NM_004126
GNG11
guanine nucleotide binding protein (G protein), gamma 11
chr15_+_52201590 2.095 TMOD3
tropomodulin 3 (ubiquitous)
chr15_+_80733579 2.071 ARNT2
aryl-hydrocarbon receptor nuclear translocator 2
chr1_+_209878135 2.069 NM_005525
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr6_+_151561094 2.066 NM_005100
AKAP12
A kinase (PRKA) anchor protein 12
chr12_-_91576579 2.040 DCN
decorin
chr8_-_13133956 2.015


chr11_-_105010460 2.006 NM_021571
CARD18
caspase recruitment domain family, member 18
chr10_+_95848811 1.996 NM_001165979
PLCE1
phospholipase C, epsilon 1
chr5_-_146460991 1.990 NM_181677
NM_181678
PPP2R2B

protein phosphatase 2, regulatory subunit B, beta

chr11_+_101918168 1.983 NM_001195005
NM_032930
C11orf70

chromosome 11 open reading frame 70

chr10_+_22540986 1.958 LOC100130992
uncharacterized LOC100130992
chr1_-_178062734 1.952 LOC100302401
uncharacterized LOC100302401
chr13_-_49110117 1.942 RCBTB2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr1_-_150738232 1.937 CTSS
cathepsin S
chr8_-_18541441 1.914 PSD3
pleckstrin and Sec7 domain containing 3
chr9_-_28719302 1.911 NM_152570
LINGO2
leucine rich repeat and Ig domain containing 2
chr11_+_86511490 1.896 NM_007173
PRSS23
protease, serine, 23
chr17_-_10633645 1.859 NM_001004313
TMEM220
transmembrane protein 220
chrX_+_117526665 1.840 WDR44
WD repeat domain 44
chr1_+_148644010 1.822 NM_001144032
PPIAL4E
peptidylprolyl isomerase A (cyclophilin A)-like 4E
chr8_+_1952875 1.820 KBTBD11
kelch repeat and BTB (POZ) domain containing 11
chr1_-_150738255 1.814 CTSS
cathepsin S
chr20_-_1165116 1.813 NM_018354
TMEM74B
transmembrane protein 74B
chr5_+_140174443 1.787 NM_018905
NM_031495
PCDHA2

protocadherin alpha 2

chr3_-_27764197 1.772 EOMES
eomesodermin
chr5_-_42811959 1.768 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr9_+_686640 1.754


chr1_+_148806014 1.733 NM_001164261
NM_001164262
PPIAL4D
PPIAL4F
peptidylprolyl isomerase A (cyclophilin A)-like 4D
peptidylprolyl isomerase A (cyclophilin A)-like 4F
chr17_-_46655544 1.729 NM_024015
HOXB4
homeobox B4
chrX_-_114252132 1.729 NM_000640
IL13RA2
interleukin 13 receptor, alpha 2
chr4_+_100737980 1.726 NM_014395
DAPP1
dual adaptor of phosphotyrosine and 3-phosphoinositides
chr5_-_150284503 1.706 NM_001172831
NM_001172832
NM_052860
ZNF300


zinc finger protein 300


chr7_+_28452143 1.704 NM_182898
CREB5
cAMP responsive element binding protein 5
chr2_+_113735595 1.690 NM_019618
IL36G
interleukin 36, gamma
chr3_-_121740968 1.659 NM_001199799
NM_001199800
NM_175924
ILDR1


immunoglobulin-like domain containing receptor 1


chr2_+_38177595 1.654 NM_001170793
NM_144713
FAM82A1

family with sequence similarity 82, member A1

chr13_+_76194569 1.654 NM_005358
LMO7
LIM domain 7
chr2_+_74120132 1.647 ACTG2
actin, gamma 2, smooth muscle, enteric
chr11_+_133938819 1.643 NM_001205329
NM_032801
JAM3

junctional adhesion molecule 3

chr5_+_42565963 1.642 NM_001242460
NM_001242461
NM_001242462
GHR


growth hormone receptor


chr5_+_59784004 1.638 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr7_-_137028433 1.620 PTN
pleiotrophin
chr5_+_140710203 1.616 NM_018912
NM_031993
PCDHGA1

protocadherin gamma subfamily A, 1

chrX_-_84634396 1.610 POF1B
premature ovarian failure, 1B
chr4_+_95376396 1.606 PDLIM5
PDZ and LIM domain 5
chrX_+_55478537 1.606 NM_014061
MAGEH1
melanoma antigen family H, 1
chr1_+_145727712 1.571 PDZK1
PDZ domain containing 1
chr3_-_123339178 1.568 MYLK
myosin light chain kinase
chr3_-_161089747 1.562 NM_001040100
SPTSSB
serine palmitoyltransferase, small subunit B
chr21_-_46348633 1.561 NM_001127491
ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr4_+_187070326 1.561 NM_001006655
FAM149A
family with sequence similarity 149, member A
chr14_+_24837225 1.559 NM_001198965
NM_004554
NFATC4

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4

chr4_-_88312221 1.555 HSD17B11
hydroxysteroid (17-beta) dehydrogenase 11
chr5_+_140777603 1.554 NM_018925
NM_032099
PCDHGB5

protocadherin gamma subfamily B, 5

chr19_-_43032525 1.549 NM_001024912
NM_001184813
NM_001184815
NM_001184816
NM_001205344
NM_001712
CEACAM1





carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)





chr19_-_7553867 1.545 NM_080662
PEX11G
peroxisomal biogenesis factor 11 gamma
chr2_+_207406815 1.542 ADAM23
ADAM metallopeptidase domain 23
chr7_-_41742666 1.534 NM_002192
INHBA
inhibin, beta A
chr5_+_132149022 1.511 NM_175873
ANKRD43
ankyrin repeat domain 43
chr1_-_47655723 1.502 NM_005764
PDZK1IP1
PDZK1 interacting protein 1
chr1_-_100643770 1.500 NM_144620
LRRC39
leucine rich repeat containing 39
chr5_-_115910406 1.498 NM_020796
SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr1_+_46640748 1.482 NM_005727
TSPAN1
tetraspanin 1
chr2_+_71680752 1.480 NM_001130976
NM_001130977
NM_001130978
NM_001130979
NM_001130980
NM_001130981
NM_003494
DYSF






dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)






chr4_-_88312329 1.475 NM_016245
HSD17B11
hydroxysteroid (17-beta) dehydrogenase 11
chr8_+_91803777 1.465 NM_022351
NECAB1
N-terminal EF-hand calcium binding protein 1
chrX_+_135278912 1.459 NM_001159701
NM_001159699
FHL1

four and a half LIM domains 1

chr6_+_3849621 1.442 NM_012135
FAM50B
family with sequence similarity 50, member B
chr2_-_40657419 1.436 NM_001112800
NM_001112801
NM_001252624
NM_021097
SLC8A1



solute carrier family 8 (sodium/calcium exchanger), member 1



chr22_-_39639967 1.434 PDGFB
platelet-derived growth factor beta polypeptide
chr5_+_42565562 1.434 NM_001242406
GHR
growth hormone receptor
chr7_-_137028275 1.430 PTN
pleiotrophin
chrX_-_135863502 1.424 NM_004840
ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr1_-_148202535 1.419 NM_001164261
NM_001164262
PPIAL4D
PPIAL4F
peptidylprolyl isomerase A (cyclophilin A)-like 4D
peptidylprolyl isomerase A (cyclophilin A)-like 4F
chr5_-_147211141 1.415 SPINK1
serine peptidase inhibitor, Kazal type 1
chr17_+_26369935 1.401 NLK
nemo-like kinase
chr5_+_140625146 1.400 NM_018935
PCDHB15
protocadherin beta 15
chr1_-_244006885 1.399 NM_001206729
AKT3
v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
chr5_+_140261792 1.397 NM_018904
NM_031865
PCDHA13

protocadherin alpha 13

chr7_-_137028370 1.396 PTN
pleiotrophin
chr8_-_72756687 1.391 NM_005098
MSC
musculin
chr3_+_190105660 1.387 NM_006580
CLDN16
claudin 16
chr6_+_121756744 1.384 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr7_+_28725597 1.384 NM_001011666
CREB5
cAMP responsive element binding protein 5
chrX_-_70331297 1.383 NM_000206
IL2RG
interleukin 2 receptor, gamma
chr15_+_74218794 1.381 LOXL1
lysyl oxidase-like 1
chr14_-_22005035 1.379 NM_005407
SALL2
sal-like 2 (Drosophila)
chr16_-_82045045 1.374 NM_145168
SDR42E1
short chain dehydrogenase/reductase family 42E, member 1
chrX_+_135251795 1.373 NM_001167819
FHL1
four and a half LIM domains 1
chr6_+_127898318 1.364 NM_001010905
C6orf58
chromosome 6 open reading frame 58
chr10_+_5488521 1.361 NM_005863
NET1
neuroepithelial cell transforming 1
chr4_-_80994309 1.359 NM_001145794
NM_058172
ANTXR2

anthrax toxin receptor 2

chr18_+_47340328 1.354


chr5_+_52776479 1.354 FST
follistatin
chr2_+_74120092 1.354 NM_001199893
NM_001615
ACTG2

actin, gamma 2, smooth muscle, enteric

chr20_+_9198036 1.338 NM_182797
PLCB4
phospholipase C, beta 4
chr6_+_31895401 1.336 C2
complement component 2
chr2_+_97202463 1.335 NM_212481
ARID5A
AT rich interactive domain 5A (MRF1-like)
chr1_-_244006471 1.330 NM_005465
NM_181690
AKT3

v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)


Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
11.67 1.49e-11 GO:0007156 homophilic cell adhesion
7.30 2.51e-11 GO:0016337 cell-cell adhesion
3.98 2.09e-08 GO:0007155 cell adhesion
3.98 2.09e-08 GO:0022610 biological adhesion
1.94 2.55e-04 GO:0048731 system development
17.68 6.85e-03 GO:0016339 calcium-dependent cell-cell adhesion
1.70 7.39e-03 GO:0007275 multicellular organismal development
1.74 8.46e-03 GO:0048856 anatomical structure development
2.12 2.96e-02 GO:0007399 nervous system development

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
3.08 2.80e-05 GO:0005615 extracellular space
2.14 3.34e-05 GO:0005576 extracellular region
2.63 1.55e-04 GO:0044421 extracellular region part
1.38 7.26e-04 GO:0016020 membrane
1.61 8.45e-04 GO:0005886 plasma membrane
1.59 1.44e-03 GO:0071944 cell periphery
1.40 3.28e-02 GO:0031224 intrinsic to membrane
1.40 4.92e-02 GO:0016021 integral to membrane

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
3.11 2.86e-04 GO:0005509 calcium ion binding
5.20 1.20e-02 GO:0005539 glycosaminoglycan binding
4.81 2.19e-02 GO:0001871 pattern binding
4.81 2.19e-02 GO:0030247 polysaccharide binding