Motif ID: HSF1,2.p2

Z-value: 1.446


Transcription factors associated with HSF1,2.p2:

Gene SymbolEntrez IDGene Name
HSF1 3297 heat shock transcription factor 1
HSF2 3298 heat shock transcription factor 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HSF1hg19_v1_chr8_+_145515437_145515472-0.421.7e-04Click!
HSF2hg19_v1_chr6_+_122720685_1227207060.281.6e-02Click!


Activity profile for motif HSF1,2.p2.

activity profile for motif HSF1,2.p2


Sorted Z-values histogram for motif HSF1,2.p2

Sorted Z-values for motif HSF1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HSF1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_-_22550057 10.522 NM_001199881
EGR3
early growth response 3
chr18_+_28898051 10.039 NM_001942
DSG1
desmoglein 1
chr8_-_22550456 9.646 EGR3
early growth response 3
chr19_+_45971249 8.873 NM_001114171
NM_006732
FOSB

FBJ murine osteosarcoma viral oncogene homolog B

chr8_-_82395401 8.444 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr8_-_22550708 8.427 NM_004430
EGR3
early growth response 3
chr4_-_57547845 8.351 NM_001145460
NM_032495
NM_139212
HOPX


HOP homeobox


chr5_+_147443534 7.980 NM_001127698
NM_001127699
NM_006846
SPINK5


serine peptidase inhibitor, Kazal type 5


chrX_-_154563735 7.653 NM_001289
CLIC2
chloride intracellular channel 2
chr12_-_45270071 7.540 NELL2
NEL-like 2 (chicken)
chr12_-_45269340 7.161 NM_001145109
NELL2
NEL-like 2 (chicken)
chr19_+_15160194 7.047 NM_012114
CASP14
caspase 14, apoptosis-related cysteine peptidase
chr13_+_53602829 5.818 NM_006418
OLFM4
olfactomedin 4
chr3_+_45067750 5.785 NM_003278
CLEC3B
C-type lectin domain family 3, member B
chr7_+_1127722 5.533 NM_001098201
GPER
G protein-coupled estrogen receptor 1
chr6_+_106534210 5.266 PRDM1
PR domain containing 1, with ZNF domain
chr16_+_55600583 5.185 NM_032330
CAPNS2
calpain, small subunit 2
chr12_+_51318515 5.096 NM_014033
METTL7A
methyltransferase like 7A
chr12_-_57328044 5.091 NM_148897
SDR9C7
short chain dehydrogenase/reductase family 9C, member 7
chr2_-_165811995 4.998 NM_001199148
NM_173512
SLC38A11

solute carrier family 38, member 11

chr2_+_11674241 4.858 NM_014668
GREB1
growth regulation by estrogen in breast cancer 1
chr12_+_51318743 4.819 METTL7A
methyltransferase like 7A
chr12_-_123187842 4.797 NM_177551
HCAR2
hydroxycarboxylic acid receptor 2
chr5_-_112770537 4.635 NM_032028
TSSK1B
testis-specific serine kinase 1B
chr12_-_123201319 4.555 NM_006018
HCAR3
hydroxycarboxylic acid receptor 3
chr2_-_73520448 4.287 NM_001965
EGR4
early growth response 4
chr15_+_47476225 4.123 NM_001198999
SEMA6D
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr2_+_11682836 4.030 NM_033090
GREB1
growth regulation by estrogen in breast cancer 1
chr6_+_159309618 4.026 NM_001195032
C6orf99
chromosome 6 open reading frame 99
chr11_-_111782447 3.978 NM_001885
CRYAB
crystallin, alpha B
chr11_-_119294242 3.896 NM_006288
THY1
Thy-1 cell surface antigen
chrX_-_17879355 3.806 NM_001172732
NM_001172739
NM_001172743
NM_021785
RAI2



retinoic acid induced 2



chr11_+_27062508 3.781 NM_003986
BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr6_+_106534188 3.768 NM_001198
PRDM1
PR domain containing 1, with ZNF domain
chr2_+_143886969 3.762 ARHGAP15
Rho GTPase activating protein 15
chr19_-_14629227 3.759 DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr19_-_14629235 3.737


chrX_-_107225588 3.734 NM_031273
TEX13B
testis expressed 13B
chr15_+_78556901 3.699 NM_001130182
DNAJA4
DnaJ (Hsp40) homolog, subfamily A, member 4
chr12_-_45269953 3.515 NELL2
NEL-like 2 (chicken)
chr19_-_14629160 3.504 NM_006145
DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr11_+_64323089 3.494 NM_018484
SLC22A11
solute carrier family 22 (organic anion/urate transporter), member 11
chr7_+_129984629 3.451 NM_001127441
NM_001127442
NM_080385
CPA5


carboxypeptidase A5


chr8_-_103666018 3.439 NM_001032282
KLF10
Kruppel-like factor 10
chr22_+_32439018 3.400 NM_000343
SLC5A1
solute carrier family 5 (sodium/glucose cotransporter), member 1
chr15_+_25101697 3.386 NM_022805
SNRPN
small nuclear ribonucleoprotein polypeptide N
chr3_-_36781351 3.376 NM_033403
DCLK3
doublecortin-like kinase 3
chr19_+_15218141 3.331 NM_033025
SYDE1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr5_-_110062365 3.312 NM_001039763
TMEM232
transmembrane protein 232
chr2_+_143886898 3.306 NM_018460
ARHGAP15
Rho GTPase activating protein 15
chr10_+_122216465 3.278 NM_001030059
PPAPDC1A
phosphatidic acid phosphatase type 2 domain containing 1A
chr2_+_162272892 3.241 TBR1
T-box, brain, 1
chr10_-_90611675 3.204 NM_144590
ANKRD22
ankyrin repeat domain 22
chr5_+_76145825 3.161 NM_130772
S100Z
S100 calcium binding protein Z
chr6_+_126240369 3.151 NM_001199622
NCOA7
nuclear receptor coactivator 7
chr2_-_100758970 3.146 NM_002285
AFF3
AF4/FMR2 family, member 3
chr1_+_151009028 3.117 NM_001159642
NM_138278
BNIPL

BCL2/adenovirus E1B 19kD interacting protein like

chr2_+_26915390 3.099 NM_002246
KCNK3
potassium channel, subfamily K, member 3
chr3_+_46539484 3.095 NM_031440
RTP3
receptor (chemosensory) transporter protein 3
chr11_-_101454658 3.090 NM_004621
TRPC6
transient receptor potential cation channel, subfamily C, member 6
chr2_-_197674875 3.065 NM_213608
C2orf66
chromosome 2 open reading frame 66
chr12_-_122658723 3.038 NM_001014336
IL31
interleukin 31
chr10_+_90484300 3.029 NM_001080518
LIPK
lipase, family member K
chr10_-_28571014 3.016 NM_173496
MPP7
membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
chr10_+_101088794 3.002 NM_020348
CNNM1
cyclin M1
chr12_-_8815266 2.993 MFAP5
microfibrillar associated protein 5
chr11_-_105010460 2.990 NM_021571
CARD18
caspase recruitment domain family, member 18
chr17_-_38978824 2.986 NM_000421
KRT10
keratin 10
chr11_+_121322848 2.937 NM_003105
SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chrX_+_134847184 2.897 NM_001017417
CT45A3
CT45A1
cancer/testis antigen family 45, member A3
cancer/testis antigen family 45, member A1
chr21_+_31802571 2.885 NM_181600
KRTAP13-4
keratin associated protein 13-4
chr3_-_42452022 2.880 NM_144634
LYZL4
lysozyme-like 4
chr10_-_64578926 2.858 NM_001136178
EGR2
early growth response 2
chr19_-_51456159 2.846 NM_001077491
NM_001077492
NM_012427
KLK5


kallikrein-related peptidase 5


chr3_-_9920633 2.834 NM_022094
CIDEC
cell death-inducing DFFA-like effector c
chrX_+_152801579 2.815 NM_001001344
NM_021949
ATP2B3

ATPase, Ca++ transporting, plasma membrane 3

chr12_+_107078476 2.809 NM_032491
RFX4
regulatory factor X, 4 (influences HLA class II expression)
chr14_-_52535737 2.784 NID2
nidogen 2 (osteonidogen)
chr3_-_48632592 2.773 NM_000094
COL7A1
collagen, type VII, alpha 1
chr2_+_11682787 2.764 GREB1
growth regulation by estrogen in breast cancer 1
chr3_-_9920471 2.741 NM_001199623
CIDEC
cell death-inducing DFFA-like effector c
chr17_+_7184978 2.735 NM_001042
SLC2A4
solute carrier family 2 (facilitated glucose transporter), member 4
chrX_+_115301957 2.721 NM_000686
AGTR2
angiotensin II receptor, type 2
chr11_-_62996998 2.713 NM_199352
SLC22A25
solute carrier family 22, member 25
chr3_+_89156804 2.708 EPHA3
EPH receptor A3
chr12_-_53242716 2.693 NM_173352
KRT78
keratin 78
chr2_+_113735595 2.663 NM_019618
IL36G
interleukin 36, gamma
chr1_-_175712669 2.660 NM_003285
TNR
tenascin R (restrictin, janusin)
chr7_+_120629444 2.645 NM_001105533
C7orf58
chromosome 7 open reading frame 58
chr2_+_166428845 2.603 NM_024969
CSRNP3
cysteine-serine-rich nuclear protein 3
chr8_-_26371387 2.581 NM_007257
PNMA2
paraneoplastic antigen MA2
chr12_+_119616594 2.558 NM_014365
HSPB8
heat shock 22kDa protein 8
chr1_-_151826042 2.554 NM_182578
THEM5
thioesterase superfamily member 5
chr1_+_109648593 2.552


chr6_-_53013581 2.547 NM_003643
GCM1
glial cells missing homolog 1 (Drosophila)
chr12_-_52967608 2.536 NM_175053
KRT74
keratin 74
chr14_-_75330535 2.518 NM_001080408
NM_001243007
PROX2

prospero homeobox 2

chr19_-_42947050 2.505 NM_198477
CXCL17
chemokine (C-X-C motif) ligand 17
chr3_-_42917191 2.502 CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr8_+_75736771 2.482 NM_015886
PI15
peptidase inhibitor 15
chr2_-_217560247 2.472 NM_000599
IGFBP5
insulin-like growth factor binding protein 5
chr7_-_14880954 2.469 NM_004080
NM_145695
DGKB

diacylglycerol kinase, beta 90kDa

chr2_+_162272800 2.462 TBR1
T-box, brain, 1
chr10_+_135340865 2.456 NM_000773
CYP2E1
cytochrome P450, family 2, subfamily E, polypeptide 1
chr2_-_142889269 2.446 NM_018557
LRP1B
low density lipoprotein receptor-related protein 1B
chr17_-_74137370 2.445 NM_001454
FOXJ1
forkhead box J1
chr17_+_7258454 2.436 NM_198154
TMEM95
transmembrane protein 95
chr10_-_5541401 2.435 NM_017422
CALML5
calmodulin-like 5
chr11_-_26593667 2.414 NM_001135091
NM_001135092
NM_145650
MUC15


mucin 15, cell surface associated


chr3_-_13057130 2.401


chr2_-_178787522 2.395 NM_001077358
PDE11A
phosphodiesterase 11A
chr2_-_136875629 2.388 NM_003467
CXCR4
chemokine (C-X-C motif) receptor 4
chr3_-_123411185 2.381 MYLK
myosin light chain kinase
chr13_-_100624162 2.380 NM_033132
ZIC5
Zic family member 5
chr22_+_32439103 2.371 SLC5A1
solute carrier family 5 (sodium/glucose cotransporter), member 1
chr1_-_112531669 2.366 NM_004980
NM_172198
KCND3

potassium voltage-gated channel, Shal-related subfamily, member 3

chr12_-_14720790 2.361 NM_024829
PLBD1
phospholipase B domain containing 1
chr1_+_117297056 2.360 NM_001767
CD2
CD2 molecule
chr4_-_149357954 2.358


chr6_+_32605182 2.356 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr19_+_47813074 2.356 NM_001736
C5AR1
complement component 5a receptor 1
chr11_+_22214574 2.354 NM_001142649
NM_213599
ANO5

anoctamin 5

chr1_+_116654375 2.353 NM_152367
MAB21L3
mab-21-like 3 (C. elegans)
chr17_-_60884010 2.350 NM_001100875
MARCH10
membrane-associated ring finger (C3HC4) 10
chr7_+_39017608 2.332 NM_001166018
NM_007252
POU6F2

POU class 6 homeobox 2

chr2_-_39187477 2.329 LOC375196
uncharacterized LOC375196
chrX_-_64196268 2.323 NM_001178033
NM_018684
ZC4H2

zinc finger, C4H2 domain containing

chr9_-_107361693 2.316 NM_001004482
OR13C5
olfactory receptor, family 13, subfamily C, member 5
chr8_+_73449625 2.294 NM_004770
KCNB2
potassium voltage-gated channel, Shab-related subfamily, member 2
chr14_-_52535945 2.291 NM_007361
NID2
nidogen 2 (osteonidogen)
chr6_+_153019029 2.285 NM_025107
MYCT1
myc target 1
chr2_+_169926084 2.283 DHRS9
dehydrogenase/reductase (SDR family) member 9
chr15_+_42651697 2.281 NM_000070
NM_024344
NM_173087
CAPN3


calpain 3, (p94)


chr19_+_2289996 2.273


chr20_+_43803539 2.271 NM_002638
PI3
peptidase inhibitor 3, skin-derived
chr3_-_133648517 2.268 NM_025041
C3orf36
chromosome 3 open reading frame 36
chrX_-_134936734 2.263 NM_001017436
CT45A3
CT45A4
cancer/testis antigen family 45, member A3
cancer/testis antigen family 45, member A4
chr3_-_139195300 2.263 NM_004164
RBP2
retinol binding protein 2, cellular
chr9_-_95298251 2.263 NM_001197295
NM_001197296
NM_001393
ECM2


extracellular matrix protein 2, female organ and adipocyte specific


chr3_+_122334461 2.248 NM_152615
PARP15
poly (ADP-ribose) polymerase family, member 15
chr4_+_76932336 2.243 NM_001130017
ART3
ADP-ribosyltransferase 3
chr7_-_132333446 2.239 NM_181775
PLXNA4
plexin A4
chr16_+_55689899 2.235 SLC6A2
solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
chr3_-_42917632 2.230 NM_004391
CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr12_+_10460416 2.198 NM_002262
NM_007334
KLRD1

killer cell lectin-like receptor subfamily D, member 1

chr7_-_150652861 2.196 NM_001204798
NM_172057
KCNH2

potassium voltage-gated channel, subfamily H (eag-related), member 2

chr1_+_120049825 2.194 NM_000862
HSD3B1
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
chr1_-_161193375 2.187 NM_001643
APOA2
apolipoprotein A-II
chr11_+_121323065 2.186 SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr14_-_60097531 2.185 NM_206852
RTN1
reticulon 1
chrX_-_134971142 2.185 NM_001017438
CT45A3
CT45A4
CT45A5
CT45A6
CT45A1
cancer/testis antigen family 45, member A3
cancer/testis antigen family 45, member A4
cancer/testis antigen family 45, member A5
cancer/testis antigen family 45, member A6
cancer/testis antigen family 45, member A1
chr16_+_71392637 2.182 CALB2
calbindin 2
chr18_-_56296188 2.178 NM_052947
ALPK2
alpha-kinase 2
chr1_+_66798095 2.171 PDE4B
phosphodiesterase 4B, cAMP-specific
chr3_+_114012832 2.170 NM_173799
TIGIT
T cell immunoreceptor with Ig and ITIM domains
chr19_-_17958773 2.140 JAK3
Janus kinase 3
chr17_-_9862765 2.137 NM_003644
GAS7
growth arrest-specific 7
chr7_-_103086511 2.121 NM_001167962
NM_198999
NM_206883
NM_206884
NM_206885
SLC26A5




solute carrier family 26, member 5 (prestin)




chr3_+_169629359 2.114 NM_182610
SAMD7
sterile alpha motif domain containing 7
chr7_-_83278478 2.111 NM_012431
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr1_-_228613025 2.111 NM_003493
HIST3H3
histone cluster 3, H3
chr19_+_51358170 2.107 NM_001030047
NM_001030048
NM_001030050
NM_001648
KLK3



kallikrein-related peptidase 3



chr1_+_202183282 2.097 NM_001017404
LGR6
leucine-rich repeat containing G protein-coupled receptor 6
chr3_-_50649110 2.094 NM_013324
NM_145071
CISH

cytokine inducible SH2-containing protein

chrX_-_64139016 2.094 ZC4H2
zinc finger, C4H2 domain containing
chr1_+_48688356 2.093 NM_001011547
NM_001135181
SLC5A9

solute carrier family 5 (sodium/glucose cotransporter), member 9

chr18_+_31319154 2.091 ASXL3
additional sex combs like 3 (Drosophila)
chr2_+_162272619 2.090 NM_006593
TBR1
T-box, brain, 1
chr17_-_39093671 2.090 NM_015515
KRT23
keratin 23 (histone deacetylase inducible)
chr12_-_14720553 2.089 PLBD1
phospholipase B domain containing 1
chr11_-_10715160 2.077 MRVI1
murine retrovirus integration site 1 homolog
chr6_+_152126807 2.069 NM_001122741
ESR1
estrogen receptor 1
chr5_+_147582338 2.063 NM_001195290
NM_205841
SPINK6

serine peptidase inhibitor, Kazal type 6

chr14_-_23388359 2.058 RBM23
RNA binding motif protein 23
chr18_-_31803514 2.048 NM_001198546
NM_001198548
NM_003787
NOL4


nucleolar protein 4


chr15_+_78556485 2.042 NM_018602
DNAJA4
DnaJ (Hsp40) homolog, subfamily A, member 4
chr14_-_23388294 2.039 RBM23
RNA binding motif protein 23
chr1_+_45274153 2.017 NM_001136537
BTBD19
BTB (POZ) domain containing 19
chr12_+_112924284 2.013 PTPN11
protein tyrosine phosphatase, non-receptor type 11
chr1_-_169555710 2.004 NM_000130
F5
coagulation factor V (proaccelerin, labile factor)
chr11_-_85338313 1.990 NM_001142699
DLG2
discs, large homolog 2 (Drosophila)
chr5_-_95748688 1.989 NM_001177876
PCSK1
proprotein convertase subtilisin/kexin type 1
chr1_+_212781969 1.987 NM_001040619
NM_001206484
NM_001206488
NM_001674
ATF3



activating transcription factor 3



chr18_-_64271215 1.982 NM_021153
CDH19
cadherin 19, type 2
chr4_+_41258941 1.968 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr1_+_53925071 1.964 NM_033067
DMRTB1
DMRT-like family B with proline-rich C-terminal, 1
chr7_+_127233688 1.961 NM_020369
FSCN3
fascin homolog 3, actin-bundling protein, testicular (Strongylocentrotus purpuratus)
chr11_-_71791734 1.953 NUMA1
nuclear mitotic apparatus protein 1
chr17_-_7991020 1.951 NM_001139
ALOX12B
arachidonate 12-lipoxygenase, 12R type
chr16_+_71392615 1.949 NM_001740
NM_007088
CALB2

calbindin 2

chrY_+_20708556 1.942 NM_153716
NM_001001877
NM_033108
NM_152584
HSFY2

HSFY1

heat shock transcription factor, Y linked 2

heat shock transcription factor, Y-linked 1

chr22_+_21128378 1.941 NM_000185
SERPIND1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr5_-_42175355 1.941


chr4_-_46125929 1.940 NM_173536
GABRG1
gamma-aminobutyric acid (GABA) A receptor, gamma 1
chr7_-_4901437 1.936 NM_020144
PAPOLB
poly(A) polymerase beta (testis specific)
chr2_+_26624776 1.923 NM_145038
CCDC164
coiled-coil domain containing 164
chr7_+_97361270 1.916 NM_003182
NM_013996
NM_013997
NM_013998
TAC1



tachykinin, precursor 1



chr11_+_1855673 1.916 NM_138567
SYT8
synaptotagmin VIII
chr3_-_150920946 1.909 NM_013308
GPR171
G protein-coupled receptor 171
chr21_+_45937499 1.904 C21orf90
chromosome 21 open reading frame 90

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.44 5.83e-06 GO:0032501 multicellular organismal process
1.32 9.58e-04 GO:0050896 response to stimulus
2.09 2.01e-03 GO:0009611 response to wounding
1.57 1.53e-02 GO:0042221 response to chemical stimulus

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.77 5.34e-06 GO:0005576 extracellular region
2.14 1.06e-05 GO:0044421 extracellular region part
2.98 2.38e-05 GO:0009986 cell surface
3.94 1.44e-03 GO:0009897 external side of plasma membrane
1.38 2.20e-03 GO:0005886 plasma membrane
1.37 3.07e-03 GO:0071944 cell periphery
2.00 4.69e-03 GO:0005615 extracellular space
2.61 9.81e-03 GO:0005578 proteinaceous extracellular matrix
1.48 3.54e-02 GO:0044459 plasma membrane part
2.31 4.12e-02 GO:0031012 extracellular matrix

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
2.08 1.03e-02 GO:0005509 calcium ion binding
6.34 3.55e-02 GO:0003823 antigen binding
1.69 4.16e-02 GO:0005215 transporter activity