Motif ID: HNF4A_NR2F1,2.p2

Z-value: 2.054


Transcription factors associated with HNF4A_NR2F1,2.p2:

Gene SymbolEntrez IDGene Name
HNF4A 3172 hepatocyte nuclear factor 4, alpha
NR2F1 7025 nuclear receptor subfamily 2, group F, member 1
NR2F2 7026 nuclear receptor subfamily 2, group F, member 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NR2F1hg19_v1_chr5_+_92918924_929190420.317.2e-03Click!
NR2F2hg19_v1_chr15_+_96876568_96876568-0.243.9e-02Click!
HNF4Ahg19_v1_chr20_+_43029936_43029957-0.085.0e-01Click!


Activity profile for motif HNF4A_NR2F1,2.p2.

activity profile for motif HNF4A_NR2F1,2.p2


Sorted Z-values histogram for motif HNF4A_NR2F1,2.p2

Sorted Z-values for motif HNF4A_NR2F1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HNF4A_NR2F1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_159656436 10.730 NM_001445
FABP6
fatty acid binding protein 6, ileal
chr17_+_78152280 9.849 NM_024110
CARD14
caspase recruitment domain family, member 14
chr1_-_29309092 9.585


chr10_+_101542554 9.421 ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr22_+_21321446 9.333 NM_001146288
AIFM3
apoptosis-inducing factor, mitochondrion-associated, 3
chr10_+_101542460 9.287 NM_000392
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr19_+_18496966 9.160 NM_004864
GDF15
growth differentiation factor 15
chr2_+_11680079 8.948 NM_148903
GREB1
growth regulation by estrogen in breast cancer 1
chr19_+_45116921 8.944 NM_001205280
IGSF23
immunoglobulin superfamily, member 23
chr2_+_11674241 8.651 NM_014668
GREB1
growth regulation by estrogen in breast cancer 1
chr20_-_62168663 8.145 NM_005975
PTK6
PTK6 protein tyrosine kinase 6
chr11_-_61062534 7.992 VWCE
von Willebrand factor C and EGF domains
chr10_+_103986142 7.711 NM_152310
ELOVL3
ELOVL fatty acid elongase 3
chr19_+_1776117 7.644


chr5_+_133842276 7.497


chr15_-_74500394 7.387 NM_001199041
STRA6
stimulated by retinoic acid gene 6 homolog (mouse)
chr3_-_196065191 7.184 TM4SF19
transmembrane 4 L six family member 19
chr19_-_17516383 7.149 NM_004335
BST2
bone marrow stromal cell antigen 2
chr6_-_24877453 7.115 NM_015864
FAM65B
family with sequence similarity 65, member B
chr7_-_99277518 6.961 NM_000777
NM_001190484
CYP3A5

cytochrome P450, family 3, subfamily A, polypeptide 5

chr17_+_7812703 6.917 CHD3
chromodomain helicase DNA binding protein 3
chr16_-_30124829 6.744 NM_024307
GDPD3
glycerophosphodiester phosphodiesterase domain containing 3
chr2_+_95940220 6.722 PROM2
prominin 2
chr16_+_3115312 6.620 NM_001012631
NM_001012633
NM_001012718
NM_004221
IL32



interleukin 32



chr19_-_59023323 6.555 NM_012254
SLC27A5
solute carrier family 27 (fatty acid transporter), member 5
chr19_+_11998609 6.526 NM_021915
ZNF69
zinc finger protein 69
chr16_-_55867016 6.475 NM_001025194
NM_001025195
NM_001266
CES1


carboxylesterase 1


chr19_-_48867149 6.339 NM_018273
TMEM143
transmembrane protein 143
chr16_-_55866972 6.224 CES1
carboxylesterase 1
chr6_-_33714681 5.910 NM_001142883
NM_054111
IP6K3

inositol hexakisphosphate kinase 3

chr5_-_42811959 5.845 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr3_-_196065243 5.701 NM_001204897
NM_001204898
NM_138461
TM4SF19


transmembrane 4 L six family member 19


chr19_-_39402797 5.567 NM_001243212
LOC643669
uncharacterized LOC643669
chr20_+_33299315 5.549 TP53INP2
tumor protein p53 inducible nuclear protein 2
chr1_+_1567556 5.440 NM_006983
MMP23B
matrix metallopeptidase 23B
chr11_-_123525300 5.409 NM_001040151
NM_018400
SCN3B

sodium channel, voltage-gated, type III, beta

chr19_-_39303520 5.381 LGALS4
lectin, galactoside-binding, soluble, 4
chr19_-_59069747 5.346 UBE2M
ubiquitin-conjugating enzyme E2M
chr2_+_95940195 5.297 NM_001165977
NM_001165978
NM_144707
PROM2


prominin 2


chr18_-_14132426 5.262 NM_145287
ZNF519
zinc finger protein 519
chr8_-_124665165 5.258 NM_001081675
KLHL38
kelch-like 38 (Drosophila)
chr10_+_114133838 5.245 NM_203379
ACSL5
acyl-CoA synthetase long-chain family member 5
chr1_+_6052357 5.238 NM_001199861
KCNAB2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
chr14_-_23284617 5.236 SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr11_-_61062697 5.219 NM_152718
VWCE
von Willebrand factor C and EGF domains
chr1_+_160085519 5.214 NM_000702
ATP1A2
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr2_-_241831385 5.200 NM_024861
C2orf54
chromosome 2 open reading frame 54
chr20_+_58630965 5.183 NM_173644
C20orf197
chromosome 20 open reading frame 197
chr2_-_130956011 5.179 NM_207312
TUBA3E
tubulin, alpha 3e
chr7_-_150721551 5.051 NM_173681
ATG9B
ATG9 autophagy related 9 homolog B (S. cerevisiae)
chr3_+_151531860 4.972 NM_001086
AADAC
arylacetamide deacetylase (esterase)
chr21_-_15918635 4.926 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr19_+_54606141 4.848 NM_004542
NDUFA3
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
chr17_+_4692226 4.843 NM_001014985
GLTPD2
glycolipid transfer protein domain containing 2
chr21_+_45432202 4.780 NM_003274
TRAPPC10
trafficking protein particle complex 10
chr1_+_9299902 4.748 H6PD
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
chr10_+_114133775 4.740 ACSL5
acyl-CoA synthetase long-chain family member 5
chr22_-_24640850 4.701 NM_001099781
NM_001099782
NM_004121
GGT5


gamma-glutamyltransferase 5


chr17_+_77893155 4.684


chr3_+_42530790 4.660 NM_001251882
VIPR1
vasoactive intestinal peptide receptor 1
chr3_-_125655881 4.628 NM_001015050
NM_001195223
ALG1L

asparagine-linked glycosylation 1-like

chr19_+_50094911 4.608 NM_020719
PRR12
proline rich 12
chr6_-_24645955 4.604 NM_001168375
NM_001168376
NM_001168374
NM_001168377
NM_014809
KIAA0319




KIAA0319




chr19_-_6720585 4.500 NM_000064
C3
complement component 3
chr1_-_26680620 4.472 NM_001039775
AIM1L
absent in melanoma 1-like
chr11_+_69061599 4.373 NM_138768
MYEOV
myeloma overexpressed (in a subset of t(11;14) positive multiple myelomas)
chr10_+_123922940 4.294 TACC2
transforming, acidic coiled-coil containing protein 2
chr2_+_74741565 4.286 NM_016170
TLX2
T-cell leukemia homeobox 2
chr19_+_54641420 4.266 NM_014516
CNOT3
CCR4-NOT transcription complex, subunit 3
chr19_-_40971623 4.245 NM_000713
BLVRB
biliverdin reductase B (flavin reductase (NADPH))
chr17_-_36729054 4.223 SRCIN1
SRC kinase signaling inhibitor 1
chr22_+_31518923 4.222 NM_001002837
INPP5J
inositol polyphosphate-5-phosphatase J
chr19_+_54641475 4.218 CNOT3
CCR4-NOT transcription complex, subunit 3
chr6_+_31982538 4.217 NM_001242823
NM_001252204
NM_007293
NM_001002029
LOC100293534
C4A

C4B
complement C4-B-like
complement component 4A (Rodgers blood group)

complement component 4B (Chido blood group)
chr22_-_50689460 4.198 HDAC10
histone deacetylase 10
chr19_+_14142261 4.188 NM_004843
IL27RA
interleukin 27 receptor, alpha
chr15_-_74494780 4.176 STRA6
stimulated by retinoic acid gene 6 homolog (mouse)
chr19_+_39616384 4.157 NM_001014831
NM_001014832
NM_001014834
NM_001014835
NM_005884
PAK4




p21 protein (Cdc42/Rac)-activated kinase 4




chr11_+_67777795 4.140 ALDH3B1
aldehyde dehydrogenase 3 family, member B1
chr11_-_119234628 4.082 USP2
ubiquitin specific peptidase 2
chr19_+_6372805 4.036 ALKBH7
alkB, alkylation repair homolog 7 (E. coli)
chr12_-_48398284 4.029 NM_001844
NM_033150
COL2A1

collagen, type II, alpha 1

chr6_-_30899926 4.014 NM_205854
SFTA2
surfactant associated 2
chr11_-_32457059 3.912 NM_000378
NM_024424
NM_024426
WT1


Wilms tumor 1


chr11_+_67777788 3.898 NM_000694
NM_001030010
ALDH3B1

aldehyde dehydrogenase 3 family, member B1

chr12_+_53443834 3.892 NM_170754
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr22_-_43089856 3.887 A4GALT
alpha 1,4-galactosyltransferase
chr19_-_1174263 3.885 NM_014963
SBNO2
strawberry notch homolog 2 (Drosophila)
chr2_-_238499317 3.827 RAB17
RAB17, member RAS oncogene family
chr22_-_38479148 3.824 NM_013356
SLC16A8
solute carrier family 16, member 8 (monocarboxylic acid transporter 3)
chr11_-_414975 3.813 NM_001135054
SIGIRR
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
chr11_-_3692544 3.812 NM_020402
CHRNA10
cholinergic receptor, nicotinic, alpha 10
chr17_-_73840422 3.765 UNC13D
unc-13 homolog D (C. elegans)
chr2_+_11886739 3.743 NM_145693
LPIN1
lipin 1
chr12_-_54779482 3.736 ZNF385A
zinc finger protein 385A
chr11_+_66742747 3.711 NM_001136485
C11orf86
chromosome 11 open reading frame 86
chr19_+_6372443 3.710 NM_032306
ALKBH7
alkB, alkylation repair homolog 7 (E. coli)
chr15_-_74494851 3.694 STRA6
stimulated by retinoic acid gene 6 homolog (mouse)
chr17_-_73840495 3.694 UNC13D
unc-13 homolog D (C. elegans)
chr2_+_219187975 3.646 PNKD
paroxysmal nonkinesigenic dyskinesia
chr19_-_58892382 3.642 NM_001129730
NM_138466
ZNF837

zinc finger protein 837

chr12_-_8043743 3.630 SLC2A14
solute carrier family 2 (facilitated glucose transporter), member 14
chr17_+_72439187 3.591 GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr19_-_1174201 3.590


chr14_-_23285011 3.587 NM_001126105
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr4_+_4543718 3.580 LOC100507266
uncharacterized LOC100507266
chr1_+_20915440 3.572 NM_001785
CDA
cytidine deaminase
chr15_+_85427891 3.570 NM_004213
NM_201651
SLC28A1

solute carrier family 28 (sodium-coupled nucleoside transporter), member 1

chr17_-_8198605 3.568 SLC25A35
solute carrier family 25, member 35
chr11_+_1861431 3.566 NM_001145841
TNNI2
troponin I type 2 (skeletal, fast)
chr17_-_19651586 3.555 NM_000691
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr19_+_44507076 3.553 NM_006300
ZNF230
zinc finger protein 230
chr19_-_55580896 3.542 NM_138412
RDH13
retinol dehydrogenase 13 (all-trans/9-cis)
chr19_-_38806546 3.542 NM_001039672
NM_001039673
NM_001145463
YIF1B


Yip1 interacting factor homolog B (S. cerevisiae)


chr19_-_41255827 3.503 NM_198476
C19orf54
chromosome 19 open reading frame 54
chr22_-_50689766 3.482 NM_001159286
NM_032019
HDAC10

histone deacetylase 10

chr19_+_46651499 3.482 NM_001135113
IGFL2
IGF-like family member 2
chr22_-_50689685 3.467 HDAC10
histone deacetylase 10
chrX_-_15511358 3.452 PIR
pirin (iron-binding nuclear protein)
chr6_-_45983279 3.448 NM_016929
CLIC5
chloride intracellular channel 5
chr20_+_31367637 3.446 NM_175850
DNMT3B
DNA (cytosine-5-)-methyltransferase 3 beta
chr9_-_95896498 3.442 NM_004148
NINJ1
ninjurin 1
chr19_+_6372720 3.441 ALKBH7
alkB, alkylation repair homolog 7 (E. coli)
chrX_-_15511710 3.422 NM_001018109
NM_003662
PIR

pirin (iron-binding nuclear protein)

chr11_+_64053581 3.385 NM_001170880
NM_020155
GPR137

G protein-coupled receptor 137

chr19_+_49458129 3.383 BAX
BCL2-associated X protein
chr11_-_65325391 3.372 LTBP3
latent transforming growth factor beta binding protein 3
chr19_+_49458151 3.355 BAX
BCL2-associated X protein
chr19_+_49128208 3.354 NM_001204160
SPHK2
sphingosine kinase 2
chr5_+_179220985 3.354 NM_145867
LTC4S
leukotriene C4 synthase
chr19_-_1174257 3.326 SBNO2
strawberry notch homolog 2 (Drosophila)
chr3_-_62359189 3.325 NM_018008
FEZF2
FEZ family zinc finger 2
chr4_-_53617781 3.325 NM_001242690
NM_024534
ERVMER34-1

endogenous retrovirus group MER34, member 1

chr19_+_49458031 3.322 NM_004324
NM_138761
NM_138763
NM_138764
BAX



BCL2-associated X protein



chr13_+_31287614 3.314 NM_001204406
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr3_-_48671278 3.312 NM_001040454
SLC26A6
solute carrier family 26, member 6
chr19_-_49622278 3.307 NM_018111
C19orf73
chromosome 19 open reading frame 73
chr19_+_45251933 3.305 NM_005178
BCL3
B-cell CLL/lymphoma 3
chr15_-_83349134 3.300 AP3B2
adaptor-related protein complex 3, beta 2 subunit
chr3_+_42544131 3.288 VIPR1
vasoactive intestinal peptide receptor 1
chr1_+_61547625 3.283 NM_001134673
NM_005595
NFIA

nuclear factor I/A

chr6_+_138188352 3.278 NM_006290
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr1_-_155271186 3.273 NM_000298
PKLR
pyruvate kinase, liver and RBC
chr2_+_211458078 3.260 NM_001122634
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr16_-_70719693 3.209 MTSS1L
metastasis suppressor 1-like
chr3_+_42544094 3.208 NM_001251883
NM_001251884
NM_001251885
NM_004624
VIPR1



vasoactive intestinal peptide receptor 1



chr6_+_31913708 3.208 NM_001710
CFB
complement factor B
chr22_-_24059502 3.208 GUSBP11
glucuronidase, beta pseudogene 11
chr2_+_211421322 3.183 NM_001875
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr10_+_70847857 3.181 SRGN
serglycin
chr16_+_56225250 3.177 NM_020988
NM_138736
GNAO1

guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O

chr2_-_132559233 3.172 NM_214461
C2orf27B
chromosome 2 open reading frame 27B
chr22_+_25003610 3.166 NM_001032365
GGT1
gamma-glutamyltransferase 1
chr1_+_26348265 3.142 NM_004455
EXTL1
exostoses (multiple)-like 1
chr19_-_55628780 3.131 NM_017607
PPP1R12C
protein phosphatase 1, regulatory subunit 12C
chr14_-_65409445 3.124 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr17_+_18281078 3.120 NM_001145127
EVPLL
envoplakin-like
chr10_-_104211244 3.109 NM_024886
C10orf95
chromosome 10 open reading frame 95
chr17_+_7905911 3.103 NM_000180
GUCY2D
guanylate cyclase 2D, membrane (retina-specific)
chr17_-_8027396 3.103 NM_001165967
NM_032580
HES7

hairy and enhancer of split 7 (Drosophila)

chr22_-_24059436 3.094


chr11_-_32452358 3.080 NM_001198551
NM_001198552
WT1

Wilms tumor 1

chr14_+_39735500 3.072 NM_001247988
NM_203356
CTAGE5

CTAGE family, member 5

chr19_+_46498338 3.058 NM_001080402
CCDC61
coiled-coil domain containing 61
chr9_+_35906188 3.051 NM_001039792
HRCT1
histidine rich carboxyl terminus 1
chr17_-_1553099 3.043 NM_031430
RILP
Rab interacting lysosomal protein
chr11_-_6462129 3.041 NM_000613
HPX
hemopexin
chr19_-_47987410 3.031 KPTN
kaptin (actin binding protein)
chr11_-_1593149 3.030 NM_004420
DUSP8
dual specificity phosphatase 8
chr11_-_116663106 3.028 NM_001166598
NM_052968
APOA5

apolipoprotein A-V

chr16_+_66995099 3.015 NM_001185177
NM_024922
CES3

carboxylesterase 3

chr19_-_18385166 3.014 NM_001145304
NM_001145305
NM_025249
KIAA1683


KIAA1683


chr12_+_113659216 3.009 NM_001143819
NM_017901
TPCN1

two pore segment channel 1

chr1_-_92949500 3.002 GFI1
growth factor independent 1 transcription repressor
chr17_+_48050129 2.999 NM_001934
DLX4
distal-less homeobox 4
chr3_+_194406614 2.999 NM_153690
FAM43A
family with sequence similarity 43, member A
chr7_+_76751933 2.995 NM_020879
CCDC146
coiled-coil domain containing 146
chr10_-_91295310 2.995 NM_213606
SLC16A12
solute carrier family 16, member 12 (monocarboxylic acid transporter 12)
chr2_+_11682836 2.987 NM_033090
GREB1
growth regulation by estrogen in breast cancer 1
chr1_-_155881063 2.981 RIT1
Ras-like without CAAX 1
chr14_+_75745480 2.972 NM_005252
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr3_-_49459870 2.948 AMT
aminomethyltransferase
chr19_-_19281062 2.942 MEF2B
myocyte enhancer factor 2B
chr19_+_45754505 2.934 NM_001199867
NM_031417
MARK4

MAP/microtubule affinity-regulating kinase 4

chr16_+_3115639 2.923 IL32
interleukin 32
chr2_+_234601511 2.917 NM_001072
UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr1_+_26146446 2.915 FAM54B
family with sequence similarity 54, member B
chr12_-_6484904 2.901 NM_001038
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr2_+_11682787 2.901 GREB1
growth regulation by estrogen in breast cancer 1
chr19_-_42498320 2.895 NM_152296
ATP1A3
ATPase, Na+/K+ transporting, alpha 3 polypeptide
chr14_+_103592663 2.872 NM_006291
TNFAIP2
tumor necrosis factor, alpha-induced protein 2
chr17_+_48049678 2.863 DLX4
distal-less homeobox 4
chr6_+_31926788 2.855 SKIV2L
superkiller viralicidic activity 2-like (S. cerevisiae)
chr15_-_74502045 2.853 NM_001199040
STRA6
stimulated by retinoic acid gene 6 homolog (mouse)
chr1_+_44457424 2.844 CCDC24
coiled-coil domain containing 24
chr1_+_222988324 2.834 NM_032890
DISP1
dispatched homolog 1 (Drosophila)
chr22_-_51021255 2.825 CHKB
choline kinase beta
chr19_-_38806381 2.822 NM_001039671
NM_001145461
NM_001145462
YIF1B


Yip1 interacting factor homolog B (S. cerevisiae)


chr22_-_42526792 2.815 CYP2D6
cytochrome P450, family 2, subfamily D, polypeptide 6
chr19_-_1111972 2.812 SBNO2
strawberry notch homolog 2 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
2.23 3.92e-07 GO:0006629 lipid metabolic process
1.80 1.91e-06 GO:0044281 small molecule metabolic process
2.21 2.04e-06 GO:0055114 oxidation-reduction process
3.03 3.80e-05 GO:0032787 monocarboxylic acid metabolic process
2.17 3.40e-04 GO:0006082 organic acid metabolic process
2.13 9.95e-04 GO:0019752 carboxylic acid metabolic process
2.13 9.95e-04 GO:0043436 oxoacid metabolic process
2.14 1.58e-03 GO:0044255 cellular lipid metabolic process
2.09 1.87e-03 GO:0042180 cellular ketone metabolic process
2.33 5.23e-03 GO:0006066 alcohol metabolic process
2.93 6.76e-03 GO:0008202 steroid metabolic process
2.96 9.02e-03 GO:0006631 fatty acid metabolic process
3.56 9.19e-03 GO:0006805 xenobiotic metabolic process
3.56 9.19e-03 GO:0071466 cellular response to xenobiotic stimulus
3.54 1.02e-02 GO:0009410 response to xenobiotic stimulus
1.37 1.62e-02 GO:0051179 localization
1.13 1.84e-02 GO:0009987 cellular process
2.32 3.84e-02 GO:0008610 lipid biosynthetic process
1.81 4.30e-02 GO:0006811 ion transport
4.18 4.43e-02 GO:0006959 humoral immune response

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
2.08 1.74e-05 GO:0005626 insoluble fraction
1.28 1.82e-04 GO:0044444 cytoplasmic part
2.98 2.93e-04 GO:0005792 microsome
1.97 3.78e-04 GO:0005624 membrane fraction
2.88 5.44e-04 GO:0042598 vesicular fraction
1.75 1.80e-03 GO:0000267 cell fraction
2.15 5.88e-03 GO:0005740 mitochondrial envelope
1.70 7.34e-03 GO:0005783 endoplasmic reticulum
2.12 1.41e-02 GO:0031966 mitochondrial membrane
1.84 1.93e-02 GO:0031967 organelle envelope
1.80 2.90e-02 GO:0031975 envelope
4.22 2.97e-02 GO:0070469 respiratory chain
1.16 3.37e-02 GO:0005737 cytoplasm

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
2.29 3.40e-06 GO:0016491 oxidoreductase activity
1.79 1.17e-02 GO:0022891 substrate-specific transmembrane transporter activity
1.72 1.47e-02 GO:0022892 substrate-specific transporter activity
1.65 1.59e-02 GO:0005215 transporter activity
1.73 2.38e-02 GO:0022857 transmembrane transporter activity
1.24 2.97e-02 GO:0003824 catalytic activity