Motif ID: HLF.p2

Z-value: 1.348


Transcription factors associated with HLF.p2:

Gene SymbolEntrez IDGene Name
HLF 3131 hepatic leukemia factor

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HLFhg19_v1_chr17_+_53343170_533432050.462.7e-05Click!


Activity profile for motif HLF.p2.

activity profile for motif HLF.p2


Sorted Z-values histogram for motif HLF.p2

Sorted Z-values for motif HLF.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HLF.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_+_69061599 14.816 NM_138768
MYEOV
myeloma overexpressed (in a subset of t(11;14) positive multiple myelomas)
chr4_+_75230856 14.278 NM_001432
EREG
epiregulin
chr10_+_123923104 11.055 NM_006997
NM_206860
TACC2

transforming, acidic coiled-coil containing protein 2

chr16_-_55866972 10.425 CES1
carboxylesterase 1
chr16_-_55867016 9.537 NM_001025194
NM_001025195
NM_001266
CES1


carboxylesterase 1


chrX_-_15620191 9.312 NM_021804
ACE2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr15_+_58430394 7.384 NM_020980
AQP9
aquaporin 9
chr19_+_45971249 7.361 NM_001114171
NM_006732
FOSB

FBJ murine osteosarcoma viral oncogene homolog B

chr12_-_53074172 7.245 NM_006121
KRT1
keratin 1
chr20_+_58630965 6.935 NM_173644
C20orf197
chromosome 20 open reading frame 197
chr14_+_103388992 6.792 NM_030943
AMN
amnionless homolog (mouse)
chr12_-_117319231 6.755 NM_003806
HRK
harakiri, BCL2 interacting protein (contains only BH3 domain)
chr21_-_15918635 6.712 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr14_-_23284617 6.659 SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr10_+_70847857 5.734 SRGN
serglycin
chr15_-_74495528 5.322 NM_001142618
STRA6
stimulated by retinoic acid gene 6 homolog (mouse)
chr17_-_39092714 5.265 KRT23
keratin 23 (histone deacetylase inducible)
chr12_-_123201319 5.048 NM_006018
HCAR3
hydroxycarboxylic acid receptor 3
chr7_+_144015217 4.824 NM_001005287
NM_001001802
OR2A1
OR2A42
olfactory receptor, family 2, subfamily A, member 1
olfactory receptor, family 2, subfamily A, member 42
chr14_-_23284565 4.783 SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr7_-_143929935 4.752 NM_001005287
NM_001001802
OR2A1
OR2A42
olfactory receptor, family 2, subfamily A, member 1
olfactory receptor, family 2, subfamily A, member 42
chr10_+_70847817 4.405 NM_002727
SRGN
serglycin
chr2_+_169926084 4.252 DHRS9
dehydrogenase/reductase (SDR family) member 9
chr15_-_74495399 3.982 STRA6
stimulated by retinoic acid gene 6 homolog (mouse)
chr17_-_39538635 3.934 NM_021013
KRT34
keratin 34
chr1_-_178840079 3.898 NM_004673
ANGPTL1
angiopoietin-like 1
chr9_-_95298251 3.862 NM_001197295
NM_001197296
NM_001393
ECM2


extracellular matrix protein 2, female organ and adipocyte specific


chr14_-_23285011 3.784 NM_001126105
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr1_+_212738675 3.754 NM_001030287
ATF3
activating transcription factor 3
chr3_+_186435097 3.723 NM_000893
NM_001102416
NM_001166451
KNG1


kininogen 1


chr14_+_96722546 3.720 NM_000710
BDKRB1
bradykinin receptor B1
chr12_-_8043743 3.692 SLC2A14
solute carrier family 2 (facilitated glucose transporter), member 14
chr3_+_157154579 3.672 NM_002852
PTX3
pentraxin 3, long
chr11_+_112047088 3.656 NM_001037290
BCO2
beta-carotene oxygenase 2
chr17_+_34431219 3.609 NM_002984
CCL4
chemokine (C-C motif) ligand 4
chr11_-_116663106 3.609 NM_001166598
NM_052968
APOA5

apolipoprotein A-V

chr15_-_74495093 3.487 NM_001199042
NM_022369
STRA6

stimulated by retinoic acid gene 6 homolog (mouse)

chr5_-_39364562 3.450 NM_001737
C9
complement component 9
chr6_-_90024936 3.331 NM_002043
GABRR2
gamma-aminobutyric acid (GABA) receptor, rho 2
chr1_-_114429996 3.196 BCL2L15
BCL2-like 15
chr13_-_20110884 3.136 NM_001141968
NM_130785
NM_199254
TPTE2


transmembrane phosphoinositide 3-phosphatase and tensin homolog 2


chr10_+_5238756 3.112 NM_001818
AKR1C4
aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
chr12_-_13256572 3.104 NM_001080554
NM_001080555
NM_001206842
GSG1


germ cell associated 1


chr6_+_150690027 3.021 NM_001164694
NM_001164695
NM_203395
IYD


iodotyrosine deiodinase


chr22_+_31518923 3.020 NM_001002837
INPP5J
inositol polyphosphate-5-phosphatase J
chr21_+_19617145 2.999 NM_024944
CHODL
chondrolectin
chr19_+_49259343 2.950 NM_019113
FGF21
fibroblast growth factor 21
chr6_+_27833033 2.934 NM_003511
HIST1H2AI
HIST1H2AL
histone cluster 1, H2ai
histone cluster 1, H2al
chr4_-_185747183 2.926 NM_001995
ACSL1
acyl-CoA synthetase long-chain family member 1
chrX_+_110339374 2.901 NM_002578
PAK3
p21 protein (Cdc42/Rac)-activated kinase 3
chr11_+_112046207 2.863 NM_031938
BCO2
beta-carotene oxygenase 2
chr12_-_88423145 2.803 NM_152589
C12orf50
chromosome 12 open reading frame 50
chr10_-_52645430 2.780 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr12_-_123187842 2.717 NM_177551
HCAR2
hydroxycarboxylic acid receptor 2
chr4_+_41700736 2.662 LIMCH1
LIM and calponin homology domains 1
chr2_-_113594325 2.660 NM_000576
IL1B
interleukin 1, beta
chr10_+_70980058 2.652 NM_025130
HKDC1
hexokinase domain containing 1
chr8_+_24298442 2.601 NM_003817
ADAM7
ADAM metallopeptidase domain 7
chr14_-_70263871 2.577 NM_003049
SLC10A1
solute carrier family 10 (sodium/bile acid cotransporter family), member 1
chr22_-_30867944 2.564 NM_174975
SEC14L3
SEC14-like 3 (S. cerevisiae)
chrX_+_9431314 2.552 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr8_+_120079423 2.508 NM_006438
COLEC10
collectin sub-family member 10 (C-type lectin)
chr3_-_120400957 2.468 HGD
homogentisate 1,2-dioxygenase
chr1_+_40839368 2.459 NM_022733
SMAP2
small ArfGAP2
chr7_+_128349111 2.454 FAM71F1
family with sequence similarity 71, member F1
chr16_+_72097124 2.447 NM_020995
HPR
haptoglobin-related protein
chr19_-_41356193 2.438 NM_000762
CYP2A6
cytochrome P450, family 2, subfamily A, polypeptide 6
chr1_+_40839429 2.434 SMAP2
small ArfGAP2
chr5_+_150399980 2.427 NM_002084
GPX3
glutathione peroxidase 3 (plasma)
chr9_-_19033183 2.410 NM_153707
FAM154A
family with sequence similarity 154, member A
chr8_+_24151579 2.392 NM_014265
NM_021777
ADAM28

ADAM metallopeptidase domain 28

chr19_-_460995 2.368 NM_012435
SHC2
SHC (Src homology 2 domain containing) transforming protein 2
chr11_-_102714240 2.333 NM_002422
MMP3
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
chr16_+_72088507 2.325 NM_001126102
NM_005143
HP

haptoglobin

chr12_-_21757752 2.322 NM_021957
GYS2
glycogen synthase 2 (liver)
chr10_+_114133775 2.314 ACSL5
acyl-CoA synthetase long-chain family member 5
chr19_+_45504686 2.279 NM_006509
RELB
v-rel reticuloendotheliosis viral oncogene homolog B
chr10_+_74653338 2.243 NM_152635
OIT3
oncoprotein induced transcript 3
chr1_-_162346579 2.229 NM_182581
C1orf111
chromosome 1 open reading frame 111
chr6_-_64029847 2.190 NM_001143940
NM_016571
LGSN

lengsin, lens protein with glutamine synthetase domain

chr11_-_4718948 2.188 NM_030774
OR51E2
olfactory receptor, family 51, subfamily E, member 2
chr9_+_101705710 2.162 NM_001855
COL15A1
collagen, type XV, alpha 1
chr9_-_19786886 2.141 NM_001193288
NM_020344
SLC24A2

solute carrier family 24 (sodium/potassium/calcium exchanger), member 2

chr2_+_113403433 2.136 NM_005415
SLC20A1
solute carrier family 20 (phosphate transporter), member 1
chr18_+_55816546 2.128 NM_001144965
NM_001144968
NM_001144969
NM_001144971
NEDD4L



neural precursor cell expressed, developmentally down-regulated 4-like



chr1_-_207143944 2.110 NM_001122979
NM_001170631
NM_032029
FCAMR


Fc receptor, IgA, IgM, high affinity


chr11_-_18258383 2.079 NM_006512
SAA4
serum amyloid A4, constitutive
chr3_+_121902529 2.077 NM_000388
CASR
calcium-sensing receptor
chr17_-_77813049 2.059 NM_003655
CBX4
chromobox homolog 4
chr2_-_134179325 2.049 NCKAP5
NCK-associated protein 5
chr7_+_143880547 2.046 NM_198495
CTAGE4
CTAGE8
CTAGE family, member 4
CTAGE family, member 8
chr5_-_160279045 2.042 NM_025153
ATP10B
ATPase, class V, type 10B
chr3_+_119501556 2.004 NM_022002
NR1I2
nuclear receptor subfamily 1, group I, member 2
chr7_+_129847699 2.002 NM_145268
C7orf45
chromosome 7 open reading frame 45
chrX_-_15332680 1.978 NM_001012428
ASB11
ankyrin repeat and SOCS box containing 11
chr12_-_16757944 1.968 LMO3
LIM domain only 3 (rhombotin-like 2)
chr19_-_51141301 1.965 NM_032298
SYT3
synaptotagmin III
chr4_-_23891608 1.959 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr5_-_58882274 1.950 NM_006203
PDE4D
phosphodiesterase 4D, cAMP-specific
chr6_-_132032156 1.920 NM_001145659
CTAGE9
CTAGE family, member 9
chr9_+_117092068 1.912 NM_000608
ORM2
orosomucoid 2
chr19_+_49109999 1.907 NM_133498
SPACA4
sperm acrosome associated 4
chr22_+_50925212 1.902 NM_017584
MIOX
myo-inositol oxygenase
chr1_-_67266930 1.897 NM_005478
INSL5
insulin-like 5
chr4_+_155484131 1.891 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr1_+_112016588 1.882 NM_174896
C1orf162
chromosome 1 open reading frame 162
chr9_+_36169384 1.882 NM_005893
CCIN
calicin
chr6_+_27782793 1.856 NM_003521
HIST1H2BM
histone cluster 1, H2bm
chr18_+_55888799 1.850 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr10_+_18629613 1.850 NM_201590
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr7_+_65958643 1.838


chr8_+_68864341 1.836 PREX2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr4_+_118955499 1.836 NM_004784
NDST3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr1_-_204183036 1.825 NM_198447
GOLT1A
golgi transport 1A
chr17_+_41924515 1.823 NM_001168322
NM_001168323
NM_001168324
NM_145273
CD300LG



CD300 molecule-like family member g



chr5_+_36606456 1.820 NM_001166696
NM_004172
SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

chrX_+_41306686 1.817 NM_022567
NYX
nyctalopin
chr4_-_185747051 1.813 ACSL1
acyl-CoA synthetase long-chain family member 1
chr5_-_138718941 1.801 SLC23A1
solute carrier family 23 (nucleobase transporters), member 1
chr7_-_143966380 1.793 NM_198495
CTAGE4
CTAGE8
CTAGE family, member 4
CTAGE family, member 8
chr5_+_147715121 1.778 NM_001040433
SPINK9
serine peptidase inhibitor, Kazal type 9
chr1_-_114430168 1.778 NM_001010922
BCL2L15
BCL2-like 15
chr9_+_117085302 1.777 NM_000607
ORM1
orosomucoid 1
chr17_-_71308118 1.773 NM_012121
CDC42EP4
CDC42 effector protein (Rho GTPase binding) 4
chr10_+_118305427 1.773 NM_000936
PNLIP
pancreatic lipase
chr7_-_37956515 1.767 NM_003014
SFRP4
secreted frizzled-related protein 4
chr6_+_31895201 1.765 NM_000063
NM_001145903
C2

complement component 2

chr3_+_62304667 1.764 C3orf14
chromosome 3 open reading frame 14
chrX_+_152224862 1.735 PNMA3
paraneoplastic antigen MA3
chr19_-_46088021 1.729 OPA3
optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
chr5_+_173472737 1.724 HMP19
HMP19 protein
chr10_-_128209996 1.711 NM_001004298
C10orf90
chromosome 10 open reading frame 90
chr1_+_11249344 1.708 NM_021146
ANGPTL7
angiopoietin-like 7
chr19_-_46088084 1.703 NM_001017989
NM_025136
OPA3

optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)

chr19_-_49250023 1.696 NM_182575
IZUMO1
izumo sperm-egg fusion 1
chr9_+_111624545 1.693 NM_006687
ACTL7A
actin-like 7A
chr20_+_16728997 1.692 NM_020157
OTOR
otoraplin
chr9_+_105757592 1.690 NM_001340
CYLC2
cylicin, basic protein of sperm head cytoskeleton 2
chr2_+_65663812 1.680 FLJ16124
FLJ16124 protein
chr17_+_11501747 1.675 NM_001372
DNAH9
dynein, axonemal, heavy chain 9
chr11_-_123525300 1.656 NM_001040151
NM_018400
SCN3B

sodium channel, voltage-gated, type III, beta

chr2_+_228678556 1.642 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr16_+_30484049 1.628 ITGAL
integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
chr19_+_49622480 1.615 NM_003660
PPFIA3
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
chr17_-_34328530 1.603 CCL14-CCL15
CCL15
CCL14-CCL15 readthrough
chemokine (C-C motif) ligand 15
chr2_-_32490688 1.601 NM_001199139
NM_021209
NLRC4

NLR family, CARD domain containing 4

chr11_-_66675334 1.594 NM_022172
PC
pyruvate carboxylase
chr5_-_147162264 1.589 JAKMIP2
janus kinase and microtubule interacting protein 2
chr7_-_15601574 1.586 NM_001004320
AGMO
alkylglycerol monooxygenase
chrY_-_15591799 1.576 UTY
ubiquitously transcribed tetratricopeptide repeat gene, Y-linked
chr10_+_123922940 1.563 TACC2
transforming, acidic coiled-coil containing protein 2
chr10_+_114154522 1.560 ACSL5
acyl-CoA synthetase long-chain family member 5
chr4_-_87770267 1.559 NM_197965
SLC10A6
solute carrier family 10 (sodium/bile acid cotransporter family), member 6
chr6_-_169654047 1.556 NM_003247
THBS2
thrombospondin 2
chr12_-_75603510 1.546 NM_139136
NM_139137
NM_153748
KCNC2


potassium voltage-gated channel, Shaw-related subfamily, member 2


chr1_-_230849936 1.541 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr19_-_41388656 1.536 NM_000764
NM_030589
CYP2A7

cytochrome P450, family 2, subfamily A, polypeptide 7

chr14_-_102975996 1.535 ANKRD9
ankyrin repeat domain 9
chr2_-_175712276 1.534 NM_001206602
CHN1
chimerin (chimaerin) 1
chr21_-_35884503 1.530 KCNE1
potassium voltage-gated channel, Isk-related family, member 1
chrX_+_15518899 1.528 NM_203281
BMX
BMX non-receptor tyrosine kinase
chr18_+_54814292 1.521 BOD1P
biorientation of chromosomes in cell division 1 pseudogene
chr18_+_55888750 1.519 NM_001144966
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr22_+_37678565 1.518 CYTH4
cytohesin 4
chr21_-_32119519 1.518 NM_181617
KRTAP21-2
keratin associated protein 21-2
chrX_+_65235279 1.516


chr5_+_149151502 1.515 NM_001172699
PPARGC1B
peroxisome proliferator-activated receptor gamma, coactivator 1 beta
chr1_+_241815579 1.513 NM_144625
WDR64
WD repeat domain 64
chr1_-_173174611 1.478 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr7_-_45026204 1.477 SNHG15
small nucleolar RNA host gene 15 (non-protein coding)
chrX_+_152224765 1.460 NM_013364
PNMA3
paraneoplastic antigen MA3
chr17_+_68100994 1.445 NM_170742
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr2_+_108994366 1.444 NM_006588
SULT1C4
sulfotransferase family, cytosolic, 1C, member 4
chr11_-_65793849 1.438 NM_053054
CATSPER1
cation channel, sperm associated 1
chr10_+_86004808 1.435 NM_001012720
NM_001012722
NM_002921
RGR


retinal G protein coupled receptor


chr19_+_35773409 1.429 NM_021175
HAMP
hepcidin antimicrobial peptide
chr14_-_77889231 1.423 NM_001113475
NOXRED1
NADP-dependent oxidoreductase domain containing 1
chr6_-_169653922 1.418 THBS2
thrombospondin 2
chr3_-_143567163 1.415 NM_173653
SLC9A9
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr16_+_30483959 1.413 NM_001114380
NM_002209
ITGAL

integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)

chr5_+_167956545 1.405


chr14_+_61447929 1.401 SLC38A6
solute carrier family 38, member 6
chr13_+_23755059 1.395 NM_000231
SGCG
sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
chr2_-_158300517 1.377 NM_004288
CYTIP
cytohesin 1 interacting protein
chr7_-_73153154 1.376 NM_001145364
NM_148912
NM_148913
ABHD11


abhydrolase domain containing 11


chr4_-_76928601 1.374 NM_002416
CXCL9
chemokine (C-X-C motif) ligand 9
chr5_+_36606667 1.368 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr19_-_46088074 1.368 OPA3
optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
chr8_-_103137134 1.362 NM_001040630
NCALD
neurocalcin delta
chr10_-_104597079 1.342 NM_000102
CYP17A1
cytochrome P450, family 17, subfamily A, polypeptide 1
chr14_+_21359542 1.326 NM_002935
RNASE3
ribonuclease, RNase A family, 3
chr12_-_54758228 1.325 NM_020370
GPR84
G protein-coupled receptor 84
chr17_-_34328607 1.323 CCL14-CCL15
CCL14-CCL15 readthrough
chr4_+_119947816 1.322 SYNPO2
synaptopodin 2
chr3_-_169587598 1.322 NM_024727
LRRC31
leucine rich repeat containing 31
chr2_-_239197091 1.308 NM_022817
PER2
period homolog 2 (Drosophila)
chr18_+_77155943 1.297 NFATC1
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
chr16_+_4606490 1.293 NM_001145011
C16orf96
chromosome 16 open reading frame 96
chr2_+_162272800 1.290 TBR1
T-box, brain, 1
chr6_-_41254392 1.289 NM_001242589
NM_001242590
NM_018643
TREM1


triggering receptor expressed on myeloid cells 1



Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
2.81 1.61e-03 GO:0009611 response to wounding
65.97 5.28e-03 GO:0055078 sodium ion homeostasis
4.30 1.02e-02 GO:0006954 inflammatory response
2.99 1.89e-02 GO:0048878 chemical homeostasis
3.29 2.83e-02 GO:0050801 ion homeostasis
4.03 4.23e-02 GO:0055065 metal ion homeostasis
3.74 4.43e-02 GO:0055080 cation homeostasis
1.87 4.71e-02 GO:0065008 regulation of biological quality

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
2.26 3.58e-06 GO:0005576 extracellular region
2.73 7.23e-05 GO:0044421 extracellular region part
2.96 1.76e-04 GO:0005615 extracellular space
14.66 2.17e-02 GO:0034364 high-density lipoprotein particle

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
21.99 6.11e-03 GO:0015125 bile acid transmembrane transporter activity
6.63 2.09e-02 GO:0015081 sodium ion transmembrane transporter activity