Motif ID: HIF1A.p2

Z-value: 1.475


Transcription factors associated with HIF1A.p2:

Gene SymbolEntrez IDGene Name
HIF1A 3091 hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HIF1Ahg19_v1_chr14_+_62162042_621623380.562.0e-07Click!


Activity profile for motif HIF1A.p2.

activity profile for motif HIF1A.p2


Sorted Z-values histogram for motif HIF1A.p2

Sorted Z-values for motif HIF1A.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HIF1A.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_113403433 7.929 NM_005415
SLC20A1
solute carrier family 20 (phosphate transporter), member 1
chr6_+_7726268 7.271 BMP6
bone morphogenetic protein 6
chr7_+_156931609 6.841 UBE3C
ubiquitin protein ligase E3C
chr7_+_156931631 6.729 NM_014671
UBE3C
ubiquitin protein ligase E3C
chr7_+_156931663 6.404 UBE3C
ubiquitin protein ligase E3C
chr5_+_176873795 6.256 NM_001174101
NM_030567
PRR7

proline rich 7 (synaptic)

chr2_-_75062214 5.766


chr3_-_183543295 5.628 NM_024871
MAP6D1
MAP6 domain containing 1
chr11_+_12132063 5.510 NM_014632
MICAL2
microtubule associated monoxygenase, calponin and LIM domain containing 2
chr18_+_43913906 5.357 RNF165
ring finger protein 165
chr17_-_3599298 5.262 P2RX5
purinergic receptor P2X, ligand-gated ion channel, 5
chr13_+_41363754 5.120 SLC25A15
solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
chr3_-_16555128 4.971 NM_015150
RFTN1
raftlin, lipid raft linker 1
chr13_+_41363546 4.911 NM_014252
SLC25A15
solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
chr13_+_41363642 4.908 SLC25A15
solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
chr7_+_128095881 4.554 NM_001098786
NM_013332
HILPDA

hypoxia inducible lipid droplet-associated

chr1_-_182573393 4.483 NM_002928
RGS16
regulator of G-protein signaling 16
chr3_-_127541160 4.378 NM_007283
MGLL
monoglyceride lipase
chr3_-_16554992 4.358 RFTN1
raftlin, lipid raft linker 1
chr4_-_4291817 4.318 LYAR
Ly1 antibody reactive homolog (mouse)
chr10_+_90639900 4.196 NM_020799
STAMBPL1
STAM binding protein-like 1
chr1_-_212873104 4.147 BATF3
basic leucine zipper transcription factor, ATF-like 3
chr4_-_4291731 4.144 NM_001145725
LYAR
Ly1 antibody reactive homolog (mouse)
chr16_+_222845 4.131 NM_000517
HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr11_+_18416111 4.014 LDHA
lactate dehydrogenase A
chr2_-_227663454 3.997 NM_005544
IRS1
insulin receptor substrate 1
chr16_+_226678 3.982 NM_000558
HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr3_-_145879222 3.981 NM_000935
NM_182943
PLOD2

procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2

chr11_+_18416106 3.952 LDHA
lactate dehydrogenase A
chr3_-_127541975 3.889 NM_001003794
MGLL
monoglyceride lipase
chr17_-_3599359 3.882 P2RX5
purinergic receptor P2X, ligand-gated ion channel, 5
chr13_-_20806533 3.816 NM_001110219
NM_001110220
NM_001110221
GJB6


gap junction protein, beta 6, 30kDa


chr8_-_75233461 3.728 NM_020647
JPH1
junctophilin 1
chr3_-_52090090 3.661 NM_001947
DUSP7
dual specificity phosphatase 7
chrX_+_16804531 3.640 NM_001168683
NM_018360
TXLNG

taxilin gamma

chr3_-_170626381 3.628 EIF5A2
eukaryotic translation initiation factor 5A2
chr6_+_43738757 3.617 VEGFA
vascular endothelial growth factor A
chr11_+_60609428 3.543 NM_024098
CCDC86
coiled-coil domain containing 86
chr8_-_145515014 3.527 BOP1
block of proliferation 1
chr11_+_18415917 3.478 NM_001135239
NM_001165415
NM_001165416
NM_005566
LDHA



lactate dehydrogenase A



chr17_-_41622727 3.445 ETV4
ets variant 4
chr3_-_170626425 3.389 NM_020390
EIF5A2
eukaryotic translation initiation factor 5A2
chr3_+_52719935 3.357 NM_014366
NM_206825
NM_206826
GNL3


guanine nucleotide binding protein-like 3 (nucleolar)


chr15_-_42264749 3.305 NM_139265
EHD4
EH-domain containing 4
chr6_+_151646634 3.275 NM_144497
AKAP12
A kinase (PRKA) anchor protein 12
chr15_-_42264687 3.272 EHD4
EH-domain containing 4
chr22_+_45098046 3.246 NM_181333
PRR5
proline rich 5 (renal)
chr9_-_140196702 3.216 NM_001004354
NRARP
NOTCH-regulated ankyrin repeat protein
chrX_+_68725077 3.211 NM_015686
FAM155B
family with sequence similarity 155, member B
chr1_+_193091057 3.190 NM_024529
CDC73
cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr1_-_41328002 3.174 NM_133467
CITED4
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4
chr8_+_74888376 3.165 NM_001040613
NM_017866
TMEM70

transmembrane protein 70

chr17_-_73874056 3.140 TRIM47
tripartite motif containing 47
chr17_-_36831156 3.006 NM_001130677
C17orf96
chromosome 17 open reading frame 96
chr6_+_10695155 2.985 NM_017906
PAK1IP1
PAK1 interacting protein 1
chr13_+_100633977 2.957 NM_007129
ZIC2
Zic family member 2
chr2_+_68384986 2.931 NM_020143
PNO1
partner of NOB1 homolog (S. cerevisiae)
chr7_-_105162551 2.927 NM_019042
PUS7
pseudouridylate synthase 7 homolog (S. cerevisiae)
chr12_+_122150638 2.923 NM_001080825
TMEM120B
transmembrane protein 120B
chr1_-_6526150 2.908 NM_001039664
NM_003790
NM_148965
NM_148966
NM_148967
NM_148970
TNFRSF25





tumor necrosis factor receptor superfamily, member 25





chr10_-_33623299 2.892 NRP1
neuropilin 1
chr3_-_145878936 2.850 PLOD2
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
chr1_+_193091220 2.836 CDC73
cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr17_-_41623246 2.833 NM_001986
ETV4
ets variant 4
chr1_+_65613211 2.818 NM_203464
NM_001005353
AK4

adenylate kinase 4

chr8_-_13133956 2.817


chr22_-_30987819 2.797 PES1
pescadillo homolog 1, containing BRCT domain (zebrafish)
chr1_+_193091165 2.786 CDC73
cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr10_+_3110818 2.776 NM_001242339
PFKP
phosphofructokinase, platelet
chr8_+_31497267 2.754 NM_013962
NRG1
neuregulin 1
chr17_-_2614926 2.752 NM_015229
KIAA0664
KIAA0664
chr1_+_193091283 2.731 CDC73
cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr1_-_247335251 2.728 NM_001243740
NM_003431
ZNF124

zinc finger protein 124

chr19_+_18530087 2.728 NM_001009998
NM_032627
SSBP4

single stranded DNA binding protein 4

chrX_-_152864435 2.722 FAM58A
family with sequence similarity 58, member A
chr6_+_111303240 2.696 NM_032194
RPF2
ribosome production factor 2 homolog (S. cerevisiae)
chr22_-_30987866 2.683 NM_001243225
NM_014303
PES1

pescadillo homolog 1, containing BRCT domain (zebrafish)

chr3_-_50374795 2.666 RASSF1
Ras association (RalGDS/AF-6) domain family member 1
chr8_+_38244647 2.648 NM_001199660
LETM2
leucine zipper-EF-hand containing transmembrane protein 2
chr19_+_38810540 2.640 KCNK6
potassium channel, subfamily K, member 6
chr1_+_193091196 2.594 CDC73
cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr8_-_23261632 2.592 LOXL2
lysyl oxidase-like 2
chr9_-_135545327 2.583 DDX31
DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
chr19_+_4909447 2.569 NM_001048201
UHRF1
ubiquitin-like with PHD and ring finger domains 1
chr4_-_7069755 2.568 NM_025196
GRPEL1
GrpE-like 1, mitochondrial (E. coli)
chr8_+_6566153 2.563 AGPAT5
1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon)
chr17_+_4402128 2.557 NM_001124758
SPNS2
spinster homolog 2 (Drosophila)
chr1_+_19578039 2.530 NM_016183
MRTO4
mRNA turnover 4 homolog (S. cerevisiae)
chr16_+_56966025 2.521 HERPUD1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr9_+_112542496 2.490 NM_053016
NM_007203
NM_147150
PALM2
PALM2-AKAP2

paralemmin 2
PALM2-AKAP2 readthrough

chr15_-_93198602 2.481 NM_207446
FAM174B
family with sequence similarity 174, member B
chr16_+_22825806 2.478 NM_006043
HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr1_-_6557471 2.476 NM_001042663
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr1_+_65613971 2.455 AK4
adenylate kinase 4
chr13_+_28494136 2.452 NM_000209
PDX1
pancreatic and duodenal homeobox 1
chr19_+_18530211 2.451 SSBP4
single stranded DNA binding protein 4
chr17_+_45000483 2.448 NM_001012511
NM_004287
NM_054022
GOSR2


golgi SNAP receptor complex member 2


chr7_+_72848108 2.447 NM_003508
FZD9
frizzled family receptor 9
chr13_-_41706587 2.442 NM_152903
KBTBD6
kelch repeat and BTB (POZ) domain containing 6
chr3_-_50329702 2.436 NM_006764
IFRD2
interferon-related developmental regulator 2
chr12_-_50677238 2.426 NM_001113546
NM_016357
LIMA1

LIM domain and actin binding 1

chr8_-_23261626 2.423 LOXL2
lysyl oxidase-like 2
chr17_-_13505217 2.412 NM_006042
HS3ST3A1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
chr17_+_80186886 2.410 NM_004207
SLC16A3
solute carrier family 16, member 3 (monocarboxylic acid transporter 4)
chr20_+_48599511 2.408 NM_005985
SNAI1
snail homolog 1 (Drosophila)
chr10_+_101419169 2.400 NM_020354
ENTPD7
ectonucleoside triphosphate diphosphohydrolase 7
chr17_+_40985412 2.396 PSME3
proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
chr16_-_2264776 2.395 NM_001042371
PGP
phosphoglycolate phosphatase
chr3_+_149689065 2.392 LOC646903
uncharacterized LOC646903
chr11_+_69924407 2.388 NM_018043
ANO1
anoctamin 1, calcium activated chloride channel
chrX_+_49687212 2.386 NM_001127898
NM_001127899
CLCN5

chloride channel 5

chr16_+_56965747 2.363 NM_001010989
NM_001010990
NM_014685
HERPUD1


homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1


chr10_-_44070008 2.362 NM_001099282
NM_001099283
NM_001099284
ZNF239


zinc finger protein 239


chr8_+_67341244 2.361 NM_015169
RRS1
RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
chr17_-_74721923 2.354 JMJD6
jumonji domain containing 6
chr17_+_1958354 2.354 NM_006497
HIC1
hypermethylated in cancer 1
chr6_+_144164472 2.348 NM_032860
LTV1
LTV1 homolog (S. cerevisiae)
chr12_-_77459198 2.344 NM_203394
E2F7
E2F transcription factor 7
chr8_+_1950304 2.325 KBTBD11
kelch repeat and BTB (POZ) domain containing 11
chr1_-_6557448 2.317 PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr3_-_179169330 2.314 NM_021629
GNB4
guanine nucleotide binding protein (G protein), beta polypeptide 4
chr10_+_102747291 2.310 NM_001163812
NM_001163813
NM_001163814
NM_021830
C10orf2



chromosome 10 open reading frame 2



chr6_+_31783530 2.296 HSPA1A
HSPA1B
heat shock 70kDa protein 1A
heat shock 70kDa protein 1B
chr3_-_145878775 2.280 PLOD2
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
chr17_-_43510279 2.276 NM_174919
ARHGAP27
Rho GTPase activating protein 27
chr5_+_121297655 2.272 NM_152546
SRFBP1
serum response factor binding protein 1
chr9_+_139247508 2.269 NM_001145639
GPSM1
G-protein signaling modulator 1
chr8_-_23261675 2.249 NM_002318
LOXL2
lysyl oxidase-like 2
chr2_+_88991166 2.240 NM_144563
RPIA
ribose 5-phosphate isomerase A
chr1_+_41445402 2.234 CTPS
CTP synthase
chr12_+_54519836 2.232 LOC400043
uncharacterized LOC400043
chr11_-_798196 2.226 NM_001191061
SLC25A22
solute carrier family 25 (mitochondrial carrier: glutamate), member 22
chr1_+_41445374 2.223 CTPS
CTP synthase
chr2_-_40006185 2.214 THUMPD2
THUMP domain containing 2
chr6_-_97345676 2.213 NDUFAF4
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 4
chr17_+_40985416 2.191 NM_005789
NM_176863
PSME3

proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)

chr1_+_763045 2.182 LOC643837
uncharacterized LOC643837
chr12_-_48152180 2.182 NM_001098532
NM_006105
RAPGEF3

Rap guanine nucleotide exchange factor (GEF) 3

chr19_-_4670375 2.173 NM_019107
C19orf10
chromosome 19 open reading frame 10
chr1_+_26496382 2.171 NM_015871
ZNF593
zinc finger protein 593
chr9_+_132388404 2.162 NM_014064
METTL11A
methyltransferase like 11A
chr1_+_41445359 2.158 CTPS
CTP synthase
chr21_+_38071432 2.158


chr5_-_154317653 2.153 NM_001252156
NM_015465
GEMIN5

gem (nuclear organelle) associated protein 5

chr19_-_1237840 2.144 NM_152769
C19orf26
chromosome 19 open reading frame 26
chr1_+_19578288 2.142 MRTO4
mRNA turnover 4 homolog (S. cerevisiae)
chr14_+_103995535 2.131 TRMT61A
tRNA methyltransferase 61 homolog A (S. cerevisiae)
chrX_+_38663072 2.128 NM_021242
MID1IP1
MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))
chr4_-_4291889 2.123 NM_017816
LYAR
Ly1 antibody reactive homolog (mouse)
chr17_+_45000493 2.121 GOSR2
golgi SNAP receptor complex member 2
chr9_+_132388451 2.113 METTL11A
methyltransferase like 11A
chr21_-_30257611 2.109 NM_013240
NM_182749
N6AMT1

N-6 adenine-specific DNA methyltransferase 1 (putative)

chr1_+_65613771 2.109 NM_013410
AK4
adenylate kinase 4
chr3_-_81810618 2.101 GBE1
glucan (1,4-alpha-), branching enzyme 1
chr8_+_48920969 2.100 NM_003350
UBE2V2
ubiquitin-conjugating enzyme E2 variant 2
chr3_-_81810914 2.079 NM_000158
GBE1
glucan (1,4-alpha-), branching enzyme 1
chr3_-_179169180 2.055 GNB4
guanine nucleotide binding protein (G protein), beta polypeptide 4
chr7_-_108096693 2.051 NM_001193582
NM_001193583
NM_001193584
NM_005010
NRCAM



neuronal cell adhesion molecule



chr9_-_2844071 2.051 KIAA0020
KIAA0020
chr13_-_20735182 2.045 NM_021954
GJA3
gap junction protein, alpha 3, 46kDa
chr6_-_97345760 2.045 NM_014165
NDUFAF4
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 4
chr14_-_69444970 2.045 ACTN1
actinin, alpha 1
chr10_+_14920781 2.039 NM_001193424
NM_001193426
NM_001193425
NM_001193427
NM_024670
SUV39H2




suppressor of variegation 3-9 homolog 2 (Drosophila)




chr16_-_12009568 2.029


chr6_+_144164509 2.028 LTV1
LTV1 homolog (S. cerevisiae)
chr17_+_40985425 2.016 PSME3
proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
chr20_+_42544781 2.006 NM_001098796
NM_032883
TOX2

TOX high mobility group box family member 2

chr11_-_68039446 2.003 NM_022338
C11orf24
chromosome 11 open reading frame 24
chr1_+_762987 1.993 LOC643837
uncharacterized LOC643837
chr3_-_81810802 1.993 GBE1
glucan (1,4-alpha-), branching enzyme 1
chr12_-_6677417 1.978 NM_001033714
NM_006170
NOP2

NOP2 nucleolar protein homolog (yeast)

chr3_-_133614421 1.973 NM_016577
RAB6B
RAB6B, member RAS oncogene family
chrX_-_152864621 1.970 NM_001130997
NM_152274
FAM58A

family with sequence similarity 58, member A

chr14_+_103995473 1.964 NM_152307
TRMT61A
tRNA methyltransferase 61 homolog A (S. cerevisiae)
chr19_+_34287662 1.949 NM_001129994
NM_001129995
NM_024076
KCTD15


potassium channel tetramerisation domain containing 15


chr20_-_62711160 1.946 NM_001039467
RGS19
regulator of G-protein signaling 19
chr11_-_797955 1.944 NM_001191060
SLC25A22
solute carrier family 25 (mitochondrial carrier: glutamate), member 22
chr2_-_224903933 1.941 NM_001136528
NM_006216
SERPINE2

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2

chrX_-_153151537 1.934


chr7_+_43622638 1.926 NM_004760
STK17A
serine/threonine kinase 17a
chr2_+_153191830 1.924 FMNL2
formin-like 2
chr19_+_55591759 1.913 NM_017729
EPS8L1
EPS8-like 1
chr2_-_158485155 1.912 ACVR1C
activin A receptor, type IC
chr22_+_24577443 1.910 NM_019601
SUSD2
sushi domain containing 2
chr2_-_85108202 1.909 C2orf89
chromosome 2 open reading frame 89
chr8_-_30515665 1.906 NM_002095
GTF2E2
general transcription factor IIE, polypeptide 2, beta 34kDa
chr3_-_73673978 1.904 NM_015009
PDZRN3
PDZ domain containing ring finger 3
chr19_+_1026582 1.898 CNN2
calponin 2
chr3_-_81810816 1.891 GBE1
glucan (1,4-alpha-), branching enzyme 1
chr3_-_50374749 1.891 RASSF1
Ras association (RalGDS/AF-6) domain family member 1
chr21_-_44299605 1.886 WDR4
WD repeat domain 4
chr11_-_68039327 1.882 C11orf24
chromosome 11 open reading frame 24
chr17_+_40985434 1.880 PSME3
proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
chr12_-_76424474 1.873 PHLDA1
pleckstrin homology-like domain, family A, member 1
chr1_+_101702304 1.867 NM_001400
S1PR1
sphingosine-1-phosphate receptor 1
chr8_-_8750739 1.865 NM_004225
MFHAS1
malignant fibrous histiocytoma amplified sequence 1
chr17_+_21279667 1.864 NM_021012
KCNJ12
potassium inwardly-rectifying channel, subfamily J, member 12
chr14_+_24769116 1.862


chr3_-_156272909 1.862 NM_007107
SSR3
signal sequence receptor, gamma (translocon-associated protein gamma)
chr1_+_245318245 1.859 NM_018012
KIF26B
kinesin family member 26B

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
5.09 7.60e-04 GO:0042254 ribosome biogenesis
3.80 3.20e-03 GO:0071843 cellular component biogenesis at cellular level
3.87 4.95e-03 GO:0034470 ncRNA processing
3.77 7.02e-03 GO:0022613 ribonucleoprotein complex biogenesis
6.77 2.45e-02 GO:0009451 RNA modification
3.11 2.67e-02 GO:0034660 ncRNA metabolic process

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
3.68 2.38e-10 GO:0005730 nucleolus
1.74 3.92e-05 GO:0043233 organelle lumen
1.74 3.95e-05 GO:0031974 membrane-enclosed lumen
1.84 5.69e-05 GO:0031981 nuclear lumen
1.74 6.83e-05 GO:0070013 intracellular organelle lumen
1.74 1.13e-04 GO:0044428 nuclear part
1.17 5.44e-04 GO:0044424 intracellular part
1.35 9.25e-04 GO:0044446 intracellular organelle part
1.23 1.21e-03 GO:0043231 intracellular membrane-bounded organelle
1.35 1.30e-03 GO:0005634 nucleus
1.23 1.33e-03 GO:0043227 membrane-bounded organelle
1.34 1.40e-03 GO:0044422 organelle part
10.56 3.59e-03 GO:0044452 nucleolar part
1.14 6.51e-03 GO:0005622 intracellular
1.18 1.63e-02 GO:0043229 intracellular organelle
1.17 1.90e-02 GO:0043226 organelle
12.57 4.84e-02 GO:0030684 preribosome

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
4.68 1.63e-02 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
15.99 2.30e-02 GO:0008175 tRNA methyltransferase activity