Motif ID: HIC1.p2

Z-value: 2.075


Transcription factors associated with HIC1.p2:

Gene SymbolEntrez IDGene Name
HIC1 3090 hypermethylated in cancer 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HIC1hg19_v1_chr17_+_1958354_19584420.404.1e-04Click!


Activity profile for motif HIC1.p2.

activity profile for motif HIC1.p2


Sorted Z-values histogram for motif HIC1.p2

Sorted Z-values for motif HIC1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HIC1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_85358851 16.842 NM_012152
LPAR3
lysophosphatidic acid receptor 3
chr3_+_71803200 16.713 NM_018971
GPR27
G protein-coupled receptor 27
chr6_-_89827605 13.639 NM_080743
SRSF12
serine/arginine-rich splicing factor 12
chr17_+_54671059 12.997 NM_005450
NOG
noggin
chr12_+_569542 12.601 NM_173593
B4GALNT3
beta-1,4-N-acetyl-galactosaminyl transferase 3
chr16_+_222845 12.433 NM_000517
HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr19_-_19006868 12.049 NM_021267
NM_198207
NM_001492
CERS1

GDF1
ceramide synthase 1

growth differentiation factor 1
chr2_-_224903933 11.729 NM_001136528
NM_006216
SERPINE2

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2

chr2_-_160761192 11.594 LY75-CD302
LY75
LY75-CD302 readthrough
lymphocyte antigen 75
chr12_+_66218879 11.506 HMGA2
high mobility group AT-hook 2
chr2_-_224903324 11.499 NM_001136530
SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr19_+_15218141 10.945 NM_033025
SYDE1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr4_-_177713664 10.849 NM_005429
VEGFC
vascular endothelial growth factor C
chr16_-_325867 10.846 NM_003834
NM_183337
RGS11

regulator of G-protein signaling 11

chr7_+_128470462 10.733 NM_001127487
NM_001458
FLNC

filamin C, gamma

chr20_+_35169876 10.320 NM_006097
NM_181526
MYL9

myosin, light chain 9, regulatory

chr15_+_101420032 9.816 ALDH1A3
aldehyde dehydrogenase 1 family, member A3
chr11_-_119187811 9.575 NM_006500
MCAM
melanoma cell adhesion molecule
chr6_+_160769365 9.138 NM_021977
SLC22A3
solute carrier family 22 (extraneuronal monoamine transporter), member 3
chr16_+_226678 8.996 NM_000558
HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr2_-_27718098 8.903 NM_022823
FNDC4
fibronectin type III domain containing 4
chr8_-_143858436 8.821 NM_177476
NM_177477
LYNX1

Ly6/neurotoxin 1

chr3_-_160822625 8.701 NM_033169
NM_001038628
NM_003781
NM_033167
NM_033168
B3GALNT1




beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)




chr15_+_101420004 8.644 NM_000693
ALDH1A3
aldehyde dehydrogenase 1 family, member A3
chr2_+_37571752 8.479 NM_012413
QPCT
glutaminyl-peptide cyclotransferase
chr5_+_52776479 8.278 FST
follistatin
chr2_-_1748240 8.210 PXDN
peroxidasin homolog (Drosophila)
chr5_-_1112106 8.188 NM_006598
SLC12A7
solute carrier family 12 (potassium/chloride transporters), member 7
chr4_-_57976355 8.149 IGFBP7
insulin-like growth factor binding protein 7
chr2_-_235405692 8.056 NM_005737
ARL4C
ADP-ribosylation factor-like 4C
chr6_-_170600165 8.010


chr22_+_26825220 7.916 NM_020437
ASPHD2
aspartate beta-hydroxylase domain containing 2
chr17_+_60705042 7.814 MRC2
mannose receptor, C type 2
chr15_+_68871285 7.785 NM_006091
CORO2B
coronin, actin binding protein, 2B
chr5_+_129240453 7.709 NM_175856
CHSY3
chondroitin sulfate synthase 3
chr10_-_62703822 7.591 NM_001242359
NM_014836
RHOBTB1

Rho-related BTB domain containing 1

chr17_+_60705051 7.589 MRC2
mannose receptor, C type 2
chr3_-_53880403 7.577 NM_018397
CHDH
choline dehydrogenase
chr16_-_80837878 7.559 NM_152342
CDYL2
chromodomain protein, Y-like 2
chr6_-_112194430 7.483 FYN
FYN oncogene related to SRC, FGR, YES
chr19_+_589849 7.429 NM_001194
HCN2
hyperpolarization activated cyclic nucleotide-gated potassium channel 2
chrX_-_153095810 7.286 PDZD4
PDZ domain containing 4
chr4_+_41258941 7.238 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr2_-_27718059 7.224 FNDC4
fibronectin type III domain containing 4
chr20_+_33146500 7.192 NM_032514
MAP1LC3A
microtubule-associated protein 1 light chain 3 alpha
chr3_-_127541975 7.120 NM_001003794
MGLL
monoglyceride lipase
chr12_+_132312917 7.113 NM_016155
MMP17
matrix metallopeptidase 17 (membrane-inserted)
chr5_+_92920592 7.104 NR2F1
NR2F2
nuclear receptor subfamily 2, group F, member 1
nuclear receptor subfamily 2, group F, member 2
chr1_+_215256559 7.015 NM_001017425
NM_014217
KCNK2

potassium channel, subfamily K, member 2

chr1_-_94702916 6.960 ARHGAP29
Rho GTPase activating protein 29
chr10_+_17271341 6.940 VIM
vimentin
chr9_+_133884503 6.883 NM_006059
LAMC3
laminin, gamma 3
chr19_+_7580987 6.850 NM_018083
ZNF358
zinc finger protein 358
chr3_-_127541160 6.822 NM_007283
MGLL
monoglyceride lipase
chr11_-_113345841 6.795 NM_000795
NM_016574
DRD2

dopamine receptor D2

chr5_+_52776263 6.777 NM_006350
NM_013409
FST

follistatin

chr1_-_20812271 6.622 CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr4_+_4387982 6.573 NM_001040101
NM_014392
D4S234E

DNA segment on chromosome 4 (unique) 234 expressed sequence

chr10_-_116164222 6.557 AFAP1L2
actin filament associated protein 1-like 2
chr12_+_66218141 6.528 NM_003483
NM_003484
HMGA2

high mobility group AT-hook 2

chr17_+_19437140 6.516 NM_018242
SLC47A1
solute carrier family 47, member 1
chr17_+_60704747 6.421 NM_006039
MRC2
mannose receptor, C type 2
chr1_-_62785067 6.371 NM_181712
KANK4
KN motif and ankyrin repeat domains 4
chr9_-_86153048 6.344 NM_001244959
NM_174938
FRMD3

FERM domain containing 3

chr1_+_28199053 6.274 NM_001039477
NM_001105556
NM_004848
C1orf38


chromosome 1 open reading frame 38


chrX_-_153095746 6.232 PDZD4
PDZ domain containing 4
chr4_-_57976516 6.194 IGFBP7
insulin-like growth factor binding protein 7
chr8_-_82024277 6.166 NM_018440
PAG1
phosphoprotein associated with glycosphingolipid microdomains 1
chr16_+_19179534 6.123 NM_016524
SYT17
synaptotagmin XVII
chr2_-_233792825 6.113 NM_001114090
NGEF
neuronal guanine nucleotide exchange factor
chr10_-_43762366 6.104 NM_145313
RASGEF1A
RasGEF domain family, member 1A
chr8_+_1922030 6.063 NM_014867
KBTBD11
kelch repeat and BTB (POZ) domain containing 11
chr2_-_1748285 6.063 NM_012293
PXDN
peroxidasin homolog (Drosophila)
chr4_-_57976550 6.057 NM_001253835
NM_001553
IGFBP7

insulin-like growth factor binding protein 7

chr2_-_95825262 6.040 NM_032788
ZNF514
zinc finger protein 514
chr6_+_7726268 5.990 BMP6
bone morphogenetic protein 6
chr2_-_227664330 5.973 IRS1
insulin receptor substrate 1
chr20_+_36531498 5.951 NM_080607
VSTM2L
V-set and transmembrane domain containing 2 like
chr18_+_10454620 5.935 NM_153000
APCDD1
adenomatosis polyposis coli down-regulated 1
chr20_+_36531548 5.926 VSTM2L
V-set and transmembrane domain containing 2 like
chr6_-_170599568 5.879 NM_005618
DLL1
delta-like 1 (Drosophila)
chr10_-_116164514 5.860 NM_001001936
NM_032550
AFAP1L2

actin filament associated protein 1-like 2

chr11_+_66790815 5.841 NM_177963
SYT12
synaptotagmin XII
chr5_-_72743829 5.807 FOXD1
forkhead box D1
chr2_-_160761266 5.789 NM_001198759
NM_001198760
NM_002349
LY75-CD302

LY75
LY75-CD302 readthrough

lymphocyte antigen 75
chr2_-_86564632 5.786 NM_001164731
NM_001164732
NM_022912
REEP1


receptor accessory protein 1


chr3_-_45267804 5.764 NM_015444
TMEM158
transmembrane protein 158 (gene/pseudogene)
chrX_+_135229536 5.759 NM_001159702
NM_001159703
NM_001449
FHL1


four and a half LIM domains 1


chr4_+_4388717 5.718 D4S234E
DNA segment on chromosome 4 (unique) 234 expressed sequence
chr13_-_20767100 5.703 NM_004004
GJB2
gap junction protein, beta 2, 26kDa
chr5_+_52776408 5.700 FST
follistatin
chr4_-_99579540 5.675 NM_005723
TSPAN5
tetraspanin 5
chr15_+_69591272 5.662 NM_017705
PAQR5
progestin and adipoQ receptor family member V
chr17_-_16472463 5.651 NM_020653
ZNF287
zinc finger protein 287
chrX_-_153151537 5.632


chr14_+_90528107 5.598 NM_022054
KCNK13
potassium channel, subfamily K, member 13
chr12_+_57998600 5.545 NM_178502
DTX3
deltex homolog 3 (Drosophila)
chr6_-_105584542 5.524 NM_007073
BVES
blood vessel epicardial substance
chr7_+_102074002 5.521 ORAI2
ORAI calcium release-activated calcium modulator 2
chr7_-_108096693 5.453 NM_001193582
NM_001193583
NM_001193584
NM_005010
NRCAM



neuronal cell adhesion molecule



chr1_+_234349995 5.410 SLC35F3
solute carrier family 35, member F3
chr9_-_21559696 5.383 MIR31HG
MIR31 host gene (non-protein coding)
chr9_+_139972195 5.346 UAP1L1
UDP-N-acteylglucosamine pyrophosphorylase 1-like 1
chr3_+_136537860 5.337 NM_001097599
NM_001097600
NM_025246
TMEM22


transmembrane protein 22


chrX_-_153979161 5.323 NM_001081573
NM_080612
GAB3

GRB2-associated binding protein 3

chr8_+_61591239 5.284 NM_017780
CHD7
chromodomain helicase DNA binding protein 7
chr12_-_47473424 5.248 NM_001143668
NM_181847
AMIGO2

adhesion molecule with Ig-like domain 2

chr11_-_12030882 5.149 NM_013253
DKK3
dickkopf 3 homolog (Xenopus laevis)
chr2_+_170335948 5.130 NM_152384
BBS5
Bardet-Biedl syndrome 5
chr1_-_1535446 5.117 NM_001242659
LOC643988
uncharacterized LOC643988
chr1_-_62784971 5.093 KANK4
KN motif and ankyrin repeat domains 4
chr13_-_110959441 5.090 NM_001845
COL4A1
collagen, type IV, alpha 1
chr12_+_26111951 5.089 NM_001164748
NM_007211
RASSF8

Ras association (RalGDS/AF-6) domain family (N-terminal) member 8

chr1_-_20812727 5.052 NM_018584
CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr21_+_46825291 5.036


chr5_+_14143287 5.001 NM_007118
TRIO
triple functional domain (PTPRF interacting)
chr16_+_30194925 4.998 CORO1A
coronin, actin binding protein, 1A
chr16_+_30194730 4.995 NM_001193333
NM_007074
CORO1A

coronin, actin binding protein, 1A

chr1_-_212873104 4.975 BATF3
basic leucine zipper transcription factor, ATF-like 3
chr21_+_46825001 4.950 NM_130445
COL18A1
collagen, type XVIII, alpha 1
chr1_-_94703252 4.937 NM_004815
ARHGAP29
Rho GTPase activating protein 29
chr17_+_74381186 4.923 NM_001142602
SPHK1
sphingosine kinase 1
chr2_+_238395863 4.917 NM_001042467
NM_024101
MLPH

melanophilin

chr9_+_33750463 4.907 NM_001197097
NM_007343
NM_001197098
PRSS3


protease, serine, 3


chr7_-_44365019 4.878 NM_001220
NM_172078
NM_172079
NM_172080
NM_172081
NM_172082
NM_172083
NM_172084
CAMK2B







calcium/calmodulin-dependent protein kinase II beta







chr17_+_74381419 4.842 SPHK1
sphingosine kinase 1
chr1_+_236305831 4.840 NM_003272
GPR137B
G protein-coupled receptor 137B
chr1_-_95392449 4.839 CNN3
calponin 3, acidic
chr4_+_2061238 4.830 NM_178557
NAT8L
N-acetyltransferase 8-like (GCN5-related, putative)
chr15_-_51386815 4.803 TNFAIP8L3
tumor necrosis factor, alpha-induced protein 8-like 3
chr1_+_210406194 4.793 NM_019605
SERTAD4
SERTA domain containing 4
chr6_+_147829784 4.782 NM_001030060
SAMD5
sterile alpha motif domain containing 5
chr9_+_4490193 4.740 NM_004170
SLC1A1
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
chr12_-_30907447 4.726 NM_001002259
NM_001206856
NM_023925
NM_032156
CAPRIN2



caprin family member 2



chr3_-_45267620 4.683 TMEM158
transmembrane protein 158 (gene/pseudogene)
chr10_+_102729249 4.680 SEMA4G
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr19_+_16187047 4.635 NM_003290
TPM4
tropomyosin 4
chr1_+_90098624 4.613 LRRC8C
leucine rich repeat containing 8 family, member C
chr10_+_17271277 4.595 VIM
vimentin
chr10_+_17270469 4.591 VIM
vimentin
chr6_-_105584982 4.552 NM_001199563
BVES
blood vessel epicardial substance
chr10_+_17271276 4.546 VIM
vimentin
chr5_-_179636124 4.534 NM_175062
RASGEF1C
RasGEF domain family, member 1C
chr4_+_84457256 4.516 AGPAT9
1-acylglycerol-3-phosphate O-acyltransferase 9
chr4_+_84457390 4.510 NM_032717
AGPAT9
1-acylglycerol-3-phosphate O-acyltransferase 9
chr1_-_200992824 4.499 NM_001252100
NM_001252102
NM_001252103
NM_017596
KIF21B



kinesin family member 21B



chr19_-_18717467 4.481 CRLF1
cytokine receptor-like factor 1
chr1_+_90098643 4.476 NM_032270
LRRC8C
leucine rich repeat containing 8 family, member C
chr15_+_80696569 4.475 NM_014862
ARNT2
aryl-hydrocarbon receptor nuclear translocator 2
chr19_+_16187306 4.467 TPM4
tropomyosin 4
chr7_-_139168408 4.457 NM_198508
KLRG2
killer cell lectin-like receptor subfamily G, member 2
chr9_+_139971938 4.453 NM_207309
UAP1L1
UDP-N-acteylglucosamine pyrophosphorylase 1-like 1
chr17_-_41623246 4.435 NM_001986
ETV4
ets variant 4
chr11_-_57335080 4.430 NM_004223
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr8_+_1950304 4.413 KBTBD11
kelch repeat and BTB (POZ) domain containing 11
chr1_-_6557471 4.391 NM_001042663
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr7_-_28220146 4.385 JAZF1
JAZF zinc finger 1
chr1_+_90098693 4.385 LRRC8C
leucine rich repeat containing 8 family, member C
chr2_-_1748317 4.380 PXDN
peroxidasin homolog (Drosophila)
chr11_-_12030622 4.370 NM_015881
DKK3
dickkopf 3 homolog (Xenopus laevis)
chr16_+_82660573 4.335 CDH13
cadherin 13, H-cadherin (heart)
chr16_+_31483066 4.331 NM_001042454
NM_001164719
TGFB1I1

transforming growth factor beta 1 induced transcript 1

chr6_-_153452383 4.326 NM_012419
RGS17
regulator of G-protein signaling 17
chr11_+_369723 4.321 NM_178537
B4GALNT4
beta-1,4-N-acetyl-galactosaminyl transferase 4
chr4_-_101111606 4.302 NM_145244
DDIT4L
DNA-damage-inducible transcript 4-like
chr10_+_17271302 4.267 VIM
vimentin
chr7_+_97841565 4.262 NM_177455
BHLHA15
basic helix-loop-helix family, member a15
chr19_+_35168558 4.261 NM_001012320
NM_018443
ZNF302

zinc finger protein 302

chr17_+_74380676 4.261 NM_001142601
NM_021972
NM_182965
SPHK1


sphingosine kinase 1


chr19_-_44952630 4.242 NM_014518
ZNF229
zinc finger protein 229
chr4_+_4388804 4.218 D4S234E
DNA segment on chromosome 4 (unique) 234 expressed sequence
chr11_-_74022609 4.217 NM_182904
P4HA3
prolyl 4-hydroxylase, alpha polypeptide III
chr2_-_1748213 4.214 PXDN
peroxidasin homolog (Drosophila)
chr11_+_69455978 4.211 CCND1
cyclin D1
chr22_-_20792107 4.179 NM_153334
NM_182895
SCARF2

scavenger receptor class F, member 2

chr16_+_22825806 4.174 NM_006043
HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr20_-_62680880 4.169 NM_018419
SOX18
SRY (sex determining region Y)-box 18
chr9_+_125133228 4.156 NM_000962
NM_080591
PTGS1

prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)

chr12_+_56137063 4.156 NM_005811
GDF11
growth differentiation factor 11
chr16_+_82660641 4.147 CDH13
cadherin 13, H-cadherin (heart)
chr19_+_17858504 4.139 NM_001161357
NM_001161358
FCHO1

FCH domain only 1

chr17_-_62657997 4.135 SMURF2
SMAD specific E3 ubiquitin protein ligase 2
chr10_-_14646407 4.131 FAM107B
family with sequence similarity 107, member B
chr19_+_35521591 4.120 NM_001037
NM_199037
SCN1B

sodium channel, voltage-gated, type I, beta

chr12_-_93965521 4.107 LOC144481
uncharacterized LOC144481
chr8_+_61591358 4.101 CHD7
chromodomain helicase DNA binding protein 7
chr2_+_101436491 4.077 NM_002518
NPAS2
neuronal PAS domain protein 2
chr14_-_58618807 4.076 NM_001001872
C14orf37
chromosome 14 open reading frame 37
chr11_-_61348290 4.071 NM_001252065
NM_004200
SYT7

synaptotagmin VII

chr14_+_105992930 4.070 NM_025268
TMEM121
transmembrane protein 121
chr10_-_44144266 4.051 NM_006973
ZNF32
zinc finger protein 32
chr19_-_18717577 4.039 CRLF1
cytokine receptor-like factor 1
chr9_-_139334274 4.011 INPP5E
inositol polyphosphate-5-phosphatase, 72 kDa
chr8_-_145018904 4.002 NM_201381
PLEC
plectin
chr5_+_71403040 3.989 NM_005909
MAP1B
microtubule-associated protein 1B
chr22_-_20792047 3.955 SCARF2
scavenger receptor class F, member 2
chr2_+_231577624 3.951 CAB39
calcium binding protein 39
chr19_-_1237840 3.942 NM_152769
C19orf26
chromosome 19 open reading frame 26
chr1_+_41249479 3.932 NM_004700
NM_172163
KCNQ4

potassium voltage-gated channel, KQT-like subfamily, member 4

chr1_-_32801606 3.932 NM_023009
MARCKSL1
MARCKS-like 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
2.00 7.27e-14 GO:0009653 anatomical structure morphogenesis
2.26 3.51e-12 GO:0022008 neurogenesis
2.28 8.68e-12 GO:0048699 generation of neurons
2.74 1.66e-11 GO:0000904 cell morphogenesis involved in differentiation
1.91 9.08e-11 GO:0009966 regulation of signal transduction
1.81 6.57e-10 GO:0023051 regulation of signaling
2.77 8.65e-10 GO:0007409 axonogenesis
2.72 1.34e-09 GO:0048667 cell morphogenesis involved in neuron differentiation
2.43 1.55e-09 GO:0000902 cell morphogenesis
1.83 2.39e-09 GO:0007399 nervous system development
2.37 2.91e-09 GO:0032989 cellular component morphogenesis
2.67 2.93e-09 GO:0048812 neuron projection morphogenesis
2.54 8.73e-09 GO:0031175 neuron projection development
2.28 4.23e-08 GO:0030030 cell projection organization
2.45 5.58e-08 GO:0048858 cell projection morphogenesis
2.43 8.16e-08 GO:0032990 cell part morphogenesis
1.63 8.56e-08 GO:0030154 cell differentiation
1.61 2.32e-07 GO:0048869 cellular developmental process
1.49 6.58e-07 GO:0048731 system development
1.63 7.10e-07 GO:0048583 regulation of response to stimulus
2.12 1.02e-06 GO:0030182 neuron differentiation
1.45 1.28e-06 GO:0048856 anatomical structure development
2.22 1.96e-06 GO:0048666 neuron development
1.39 2.34e-06 GO:0032502 developmental process
1.42 2.50e-06 GO:0007275 multicellular organismal development
1.92 2.90e-06 GO:0048468 cell development
2.62 4.58e-06 GO:0007411 axon guidance
1.38 1.55e-05 GO:0023052 signaling
1.87 5.60e-05 GO:0040011 locomotion
1.22 9.10e-05 GO:0050794 regulation of cellular process
1.37 1.95e-04 GO:0007165 signal transduction
1.77 6.50e-04 GO:0050793 regulation of developmental process
2.06 6.84e-04 GO:0006935 chemotaxis
2.06 6.84e-04 GO:0042330 taxis
1.19 7.23e-04 GO:0065007 biological regulation
2.59 8.06e-04 GO:0050767 regulation of neurogenesis
1.19 1.25e-03 GO:0050789 regulation of biological process
1.83 1.34e-03 GO:2000026 regulation of multicellular organismal development
1.44 2.45e-03 GO:0048523 negative regulation of cellular process
1.85 2.64e-03 GO:0045595 regulation of cell differentiation
1.59 3.20e-03 GO:0051239 regulation of multicellular organismal process
2.36 4.67e-03 GO:0051960 regulation of nervous system development
2.26 5.19e-03 GO:0060284 regulation of cell development
2.04 6.53e-03 GO:0023057 negative regulation of signaling
2.03 6.99e-03 GO:0010648 negative regulation of cell communication
1.40 7.22e-03 GO:0048519 negative regulation of biological process
2.06 1.07e-02 GO:0009968 negative regulation of signal transduction
1.93 1.16e-02 GO:0007417 central nervous system development
2.10 1.32e-02 GO:0048598 embryonic morphogenesis
1.45 1.48e-02 GO:0007166 cell surface receptor linked signaling pathway
2.09 1.53e-02 GO:0051056 regulation of small GTPase mediated signal transduction
1.76 2.02e-02 GO:0009790 embryo development
3.05 2.88e-02 GO:0035023 regulation of Rho protein signal transduction
1.26 2.91e-02 GO:0051716 cellular response to stimulus
1.88 3.65e-02 GO:0048585 negative regulation of response to stimulus
2.15 3.98e-02 GO:0022603 regulation of anatomical structure morphogenesis
1.58 4.22e-02 GO:0010646 regulation of cell communication

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.48 1.36e-05 GO:0044459 plasma membrane part
1.32 2.19e-05 GO:0005886 plasma membrane
1.31 2.70e-05 GO:0071944 cell periphery
1.20 2.87e-05 GO:0016020 membrane
1.79 4.14e-03 GO:0030054 cell junction
1.44 1.21e-02 GO:0005856 cytoskeleton
2.91 1.26e-02 GO:0030055 cell-substrate junction
2.44 2.18e-02 GO:0070161 anchoring junction
2.86 2.62e-02 GO:0005924 cell-substrate adherens junction
2.46 3.79e-02 GO:0005912 adherens junction
11.66 4.62e-02 GO:0005587 collagen type IV
2.83 4.82e-02 GO:0005925 focal adhesion

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
2.05 4.08e-04 GO:0030695 GTPase regulator activity
3.65 4.15e-04 GO:0005088 Ras guanyl-nucleotide exchange factor activity
1.94 7.60e-04 GO:0008092 cytoskeletal protein binding
1.99 9.14e-04 GO:0060589 nucleoside-triphosphatase regulator activity
3.83 1.56e-03 GO:0005089 Rho guanyl-nucleotide exchange factor activity
2.75 2.18e-03 GO:0005085 guanyl-nucleotide exchange factor activity
2.15 9.49e-03 GO:0005083 small GTPase regulator activity