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Motif ID: HES1.p2

Z-value: 1.960

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr17_+_74380676	15.388	NM_001142601 NM_021972 NM_182965	SPHK1	sphingosine kinase 1
chr2_+_113403433	13.967	NM_005415	SLC20A1	solute carrier family 20 (phosphate transporter), member 1
chr2_-_86116016	13.519	NM_003896	ST3GAL5	ST3 beta-galactoside alpha-2,3-sialyltransferase 5
chr8_-_12612968	10.825	NM_152271	LONRF1	LON peptidase N-terminal domain and ring finger 1
chr2_+_228736326	10.414	NM_178821	WDR69	WD repeat domain 69
chr17_+_74381186	10.308	NM_001142602	SPHK1	sphingosine kinase 1
chr17_+_74380943	9.433		SPHK1	sphingosine kinase 1
chr11_+_12132063	8.504	NM_014632	MICAL2	microtubule associated monoxygenase, calponin and LIM domain containing 2
chr6_+_151561508	8.195		AKAP12	A kinase (PRKA) anchor protein 12
chr15_-_101459410	7.717
chr1_-_212873104	7.668		BATF3	basic leucine zipper transcription factor, ATF-like 3
chr7_-_558810	7.494		PDGFA	platelet-derived growth factor alpha polypeptide
chr1_-_9189087	7.314	NM_024980	GPR157	G protein-coupled receptor 157
chr6_+_151561571	7.304
chr19_+_1753661	7.196	NM_001080488	ONECUT3	one cut homeobox 3
chr11_-_2950593	6.949	NM_003311	PHLDA2	pleckstrin homology-like domain, family A, member 2
chr1_-_53793583	6.881		LRP8	low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
chr19_+_8429010	6.803	NM_001039667 NM_139314	ANGPTL4	angiopoietin-like 4
chr2_+_85766291	6.758		MAT2A	methionine adenosyltransferase II, alpha
chr15_-_74726258	6.378	NM_001146029 NM_003612	SEMA7A	semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
chr10_-_14646237	6.248		FAM107B	family with sequence similarity 107, member B
chr1_-_53793743	6.163	NM_001018054 NM_004631 NM_017522 NM_033300	LRP8	low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
chr4_-_4291817	6.063		LYAR	Ly1 antibody reactive homolog (mouse)
chr19_-_1863425	5.968		KLF16	Kruppel-like factor 16
chr21_-_46962281	5.958	NM_001205206 NM_194255	SLC19A1	solute carrier family 19 (folate transporter), member 1
chr3_-_52090090	5.945	NM_001947	DUSP7	dual specificity phosphatase 7
chr11_-_61684981	5.867	NM_013401	RAB3IL1	RAB3A interacting protein (rabin3)-like 1
chr7_-_994371	5.837		ADAP1	ArfGAP with dual PH domains 1
chr8_-_29206321	5.777	NM_057158	DUSP4	dual specificity phosphatase 4
chr4_-_4291889	5.590	NM_017816	LYAR	Ly1 antibody reactive homolog (mouse)
chr7_+_155089614	5.440		INSIG1	insulin induced gene 1
chr17_+_74381419	5.419		SPHK1	sphingosine kinase 1
chr12_-_76425207	5.349		PHLDA1	pleckstrin homology-like domain, family A, member 1
chr5_+_131630065	5.319	NM_003059	SLC22A4	solute carrier family 22 (organic cation/ergothioneine transporter), member 4
chr19_-_1863546	5.227	NM_031918	KLF16	Kruppel-like factor 16
chr5_-_54523142	5.168	NM_001190787	IDAS	Idas protein
chr6_+_43738757	5.137		VEGFA	vascular endothelial growth factor A
chr16_+_577833	5.041	NM_005632	SOLH	small optic lobes homolog (Drosophila)
chr10_+_129705299	5.016	NM_006504	PTPRE	protein tyrosine phosphatase, receptor type, E
chr18_+_48086402	4.960	NM_002747	MAPK4	mitogen-activated protein kinase 4
chr7_-_994259	4.940	NM_006869	ADAP1	ArfGAP with dual PH domains 1
chr6_+_157802479	4.872	NM_024630 NM_153746	ZDHHC14	zinc finger, DHHC-type containing 14
chr2_-_216878314	4.752	NM_018000	MREG	melanoregulin
chr19_+_30302861	4.752	NM_001238	CCNE1	cyclin E1
chr20_+_35234210	4.751		C20orf24	chromosome 20 open reading frame 24
chr6_+_151561653	4.750		AKAP12	A kinase (PRKA) anchor protein 12
chr17_+_30813928	4.739	NM_003885	CDK5R1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr11_-_32452358	4.721	NM_001198551 NM_001198552	WT1	Wilms tumor 1
chr19_+_34287662	4.673	NM_001129994 NM_001129995 NM_024076	KCTD15	potassium channel tetramerisation domain containing 15
chr12_-_33049664	4.664	NM_001005242 NM_004572	PKP2	plakophilin 2
chr8_-_141645603	4.649	NM_001164623 NM_012154	EIF2C2	eukaryotic translation initiation factor 2C, 2
chr3_-_50649080	4.611		CISH	cytokine inducible SH2-containing protein
chr7_-_559030	4.561		PDGFA	platelet-derived growth factor alpha polypeptide
chr7_+_155089483	4.441	NM_005542 NM_198336 NM_198337	INSIG1	insulin induced gene 1
chr11_+_65082288	4.412	NM_006779	CDC42EP2	CDC42 effector protein (Rho GTPase binding) 2
chr21_+_45209398	4.365	NM_003683	RRP1	ribosomal RNA processing 1 homolog (S. cerevisiae)
chr19_-_1237840	4.343	NM_152769	C19orf26	chromosome 19 open reading frame 26
chr1_+_165797060	4.337		UCK2	uridine-cytidine kinase 2
chr17_-_79479780	4.328		ACTG1	actin, gamma 1
chr1_-_223537400	4.321	NM_001037175 NM_017982	SUSD4	sushi domain containing 4
chr12_-_76425375	4.278	NM_007350	PHLDA1	pleckstrin homology-like domain, family A, member 1
chr1_+_162531349	4.218		UAP1	UDP-N-acteylglucosamine pyrophosphorylase 1
chr1_-_200992824	4.217	NM_001252100 NM_001252102 NM_001252103 NM_017596	KIF21B	kinesin family member 21B
chr1_-_201368434	4.209		LAD1	ladinin 1
chr17_+_77751929	4.197	NM_005189 NM_032647	CBX2	chromobox homolog 2
chr17_+_4402128	4.170	NM_001124758	SPNS2	spinster homolog 2 (Drosophila)
chr17_-_8027396	4.158	NM_001165967 NM_032580	HES7	hairy and enhancer of split 7 (Drosophila)
chr2_-_10588451	4.153	NM_002539	ODC1	ornithine decarboxylase 1
chr10_+_129705359	4.142		PTPRE	protein tyrosine phosphatase, receptor type, E
chr10_+_90639900	4.133	NM_020799	STAMBPL1	STAM binding protein-like 1
chr18_+_47088400	4.092	NM_006033	LIPG	lipase, endothelial
chr11_-_67888670	4.092		CHKA	choline kinase alpha
chr19_-_3557566	4.083	NM_001042680 NM_021731 NM_174983	MFSD12	major facilitator superfamily domain containing 12
chr7_-_102985068	4.064	NM_001129887 NM_014377	DNAJC2	DnaJ (Hsp40) homolog, subfamily C, member 2
chr18_+_12948010	4.009		SEH1L	SEH1-like (S. cerevisiae)
chr22_+_32340435	3.987	NM_003405	YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
chrX_+_149529828	3.930		MAMLD1	mastermind-like domain containing 1
chr19_-_3557400	3.907		MFSD12	major facilitator superfamily domain containing 12
chr11_+_65154093	3.880		FRMD8	FERM domain containing 8
chr2_+_10443020	3.863	NM_002149	HPCAL1	hippocalcin-like 1
chr19_+_1248548	3.822	NM_177401	MIDN	midnolin
chr1_-_231175971	3.818	NM_198552	FAM89A	family with sequence similarity 89, member A
chr2_-_130956011	3.788	NM_207312	TUBA3E	tubulin, alpha 3e
chr21_+_45209448	3.780		RRP1	ribosomal RNA processing 1 homolog (S. cerevisiae)
chr3_+_133292557	3.721		CDV3	CDV3 homolog (mouse)
chr19_-_3557551	3.699		MFSD12	major facilitator superfamily domain containing 12
chr3_-_183543295	3.692	NM_024871	MAP6D1	MAP6 domain containing 1
chr12_-_123380608	3.677
chr17_+_35849950	3.672	NM_007026	DUSP14	dual specificity phosphatase 14
chr16_+_30194730	3.655	NM_001193333 NM_007074	CORO1A	coronin, actin binding protein, 1A
chr19_+_49622480	3.629	NM_003660	PPFIA3	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
chr12_-_89745753	3.612		DUSP6	dual specificity phosphatase 6
chr1_-_11120081	3.599	NM_003132	SRM	spermidine synthase
chr12_-_107487585	3.590	NM_004075	CRY1	cryptochrome 1 (photolyase-like)
chr17_-_73874056	3.566		TRIM47	tripartite motif containing 47
chr1_+_229761988	3.563		URB2	URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
chr3_-_45267068	3.519		TMEM158	transmembrane protein 158 (gene/pseudogene)
chr19_+_30433111	3.491	NM_003796 NM_134447	URI1	URI1, prefoldin-like chaperone
chr12_-_121905036	3.471		KDM2B	lysine (K)-specific demethylase 2B
chr2_-_43453724	3.470		ZFP36L2	zinc finger protein 36, C3H type-like 2
chr19_-_1885375	3.442		FAM108A1	family with sequence similarity 108, member A1
chr9_+_130830447	3.436	NM_001006641	SLC25A25	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr10_-_735522	3.433	NM_014974	DIP2C	DIP2 disco-interacting protein 2 homolog C (Drosophila)
chr6_+_37137882	3.427	NM_001243186 NM_002648	PIM1	pim-1 oncogene
chr13_+_51796363	3.413	NM_001242312 NM_145019	FAM124A	family with sequence similarity 124A
chr1_+_9599546	3.407		SLC25A33	solute carrier family 25, member 33
chr9_-_130331350	3.404	NM_022833	FAM129B	family with sequence similarity 129, member B
chr1_-_33815411	3.399		PHC2	polyhomeotic homolog 2 (Drosophila)
chr14_+_20937537	3.394	NM_000270	PNP	purine nucleoside phosphorylase
chr16_+_2525108	3.376	NM_001199107 NM_020705	TBC1D24	TBC1 domain family, member 24
chr16_+_84733611	3.360		USP10	ubiquitin specific peptidase 10
chr12_-_109251333	3.354	NM_001161330 NM_018984	SSH1	slingshot homolog 1 (Drosophila)
chr1_-_33815340	3.354		PHC2	polyhomeotic homolog 2 (Drosophila)
chr1_+_15250578	3.347	NM_001018000	KAZN	kazrin, periplakin interacting protein
chr17_-_74722614	3.339		JMJD6	jumonji domain containing 6
chr3_+_133292714	3.323		CDV3	CDV3 homolog (mouse)
chr1_+_23037329	3.317	NM_004442 NM_017449	EPHB2	EPH receptor B2
chr7_+_43152196	3.281	NM_015052	HECW1	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
chr2_-_204399906	3.273	NM_203365 NM_213589	RAPH1	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
chr7_-_91763775	3.273		CYP51A1	cytochrome P450, family 51, subfamily A, polypeptide 1
chr19_+_38397841	3.272	NM_015073	SIPA1L3	signal-induced proliferation-associated 1 like 3
chr11_+_65657874	3.271	NM_006848	CCDC85B	coiled-coil domain containing 85B
chr17_-_74722517	3.230		JMJD6	jumonji domain containing 6
chr7_-_994008	3.229		ADAP1	ArfGAP with dual PH domains 1
chr3_-_127541975	3.220	NM_001003794	MGLL	monoglyceride lipase
chr16_+_2653350	3.220		LOC652276	potassium channel tetramerisation domain containing 5 pseudogene
chr6_-_30654406	3.203		PPP1R18	protein phosphatase 1, regulatory subunit 18
chr1_-_94374986	3.198	NM_002061	GCLM	glutamate-cysteine ligase, modifier subunit
chr1_-_212873306	3.196	NM_018664	BATF3	basic leucine zipper transcription factor, ATF-like 3
chr19_+_1776117	3.196
chr8_-_42397048	3.194	NM_006749	SLC20A2	solute carrier family 20 (phosphate transporter), member 2
chr4_-_4291731	3.193	NM_001145725	LYAR	Ly1 antibody reactive homolog (mouse)
chr7_+_102105459	3.186		LRWD1	leucine-rich repeats and WD repeat domain containing 1
chr20_+_35234152	3.183		C20orf24	chromosome 20 open reading frame 24
chr17_-_74722629	3.182		JMJD6	jumonji domain containing 6
chr20_+_48599511	3.177	NM_005985	SNAI1	snail homolog 1 (Drosophila)
chr20_+_35234077	3.166	NM_001199534 NM_018840 NM_199483	C20orf24	chromosome 20 open reading frame 24
chr6_+_43738394	3.164		VEGFA	vascular endothelial growth factor A
chr1_+_210406194	3.157	NM_019605	SERTAD4	SERTA domain containing 4
chr16_+_84733596	3.145		USP10	ubiquitin specific peptidase 10
chr3_-_127541160	3.138	NM_007283	MGLL	monoglyceride lipase
chr2_-_43453146	3.134		ZFP36L2	zinc finger protein 36, C3H type-like 2
chr4_-_46391771	3.126	NM_000807	GABRA2	gamma-aminobutyric acid (GABA) A receptor, alpha 2
chr6_-_13814546	3.115	NM_001031713	CCDC90A	coiled-coil domain containing 90A
chr2_+_75061234	3.105		HK2	hexokinase 2
chr11_+_65658101	3.101		CCDC85B	coiled-coil domain containing 85B
chr11_+_69455837	3.091	NM_053056	CCND1	cyclin D1
chr17_-_74721923	3.076		JMJD6	jumonji domain containing 6
chr16_+_84733554	3.065	NM_005153	USP10	ubiquitin specific peptidase 10
chr8_-_133493003	3.052	NM_004519	KCNQ3	potassium voltage-gated channel, KQT-like subfamily, member 3
chr12_+_26111951	3.042	NM_001164748 NM_007211	RASSF8	Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr1_-_94375028	3.037		GCLM	glutamate-cysteine ligase, modifier subunit
chr4_-_24586015	3.030		DHX15	DEAH (Asp-Glu-Ala-His) box polypeptide 15
chr1_+_118472364	3.029	NM_006784	WDR3	WD repeat domain 3
chr11_+_93862143	3.028		PANX1	pannexin 1
chr10_+_134210691	3.021	NM_001098637 NM_138499	PWWP2B	PWWP domain containing 2B
chr5_-_6633149	3.009		NSUN2	NOP2/Sun domain family, member 2
chr16_+_84733606	3.006		USP10	ubiquitin specific peptidase 10
chr1_-_94374949	3.002		GCLM	glutamate-cysteine ligase, modifier subunit
chr1_-_212873197	2.998		BATF3	basic leucine zipper transcription factor, ATF-like 3
chr2_+_200776025	2.995		C2orf69	chromosome 2 open reading frame 69
chr9_+_95947211	2.993	NM_006648	WNK2	WNK lysine deficient protein kinase 2
chr6_-_159239254	2.989		EZR	ezrin
chr19_-_1885485	2.988	NM_001130111 NM_031213	FAM108A1	family with sequence similarity 108, member A1
chr7_+_130131172	2.981	NM_177525	MEST	mesoderm specific transcript homolog (mouse)
chr6_-_150390171	2.979	NM_024518	ULBP3	UL16 binding protein 3
chr6_+_126070813	2.951		HEY2	hairy/enhancer-of-split related with YRPW motif 2
chr2_+_238536183	2.950	NM_001137550	LRRFIP1	leucine rich repeat (in FLII) interacting protein 1
chr5_-_32444829	2.948	NM_016107	ZFR	zinc finger RNA binding protein
chr21_-_44495894	2.947	NM_000071	CBS	cystathionine-beta-synthase
chr3_-_45267620	2.946		TMEM158	transmembrane protein 158 (gene/pseudogene)
chr22_+_46731598	2.930		TRMU	tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
chr6_-_159239269	2.929	NM_003379	EZR	ezrin
chr17_-_3599298	2.926		P2RX5	purinergic receptor P2X, ligand-gated ion channel, 5
chrX_-_71526583	2.917	NM_004143	CITED1	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
chr9_+_131451519	2.913		SET	SET nuclear oncogene
chr16_+_69166487	2.900	NM_032830	CIRH1A	cirrhosis, autosomal recessive 1A (cirhin)
chr1_-_33815498	2.899	NM_004427	PHC2	polyhomeotic homolog 2 (Drosophila)
chr2_+_85766100	2.890	NM_005911	MAT2A	methionine adenosyltransferase II, alpha
chr2_-_43453737	2.887	NM_006887	ZFP36L2	zinc finger protein 36, C3H type-like 2
chr12_-_109251271	2.875		SSH1	slingshot homolog 1 (Drosophila)
chr2_+_85766286	2.865		MAT2A	methionine adenosyltransferase II, alpha
chr21_+_46359896	2.856	NM_058190	FAM207A	family with sequence similarity 207, member A
chr6_+_43738177	2.845		VEGFA	vascular endothelial growth factor A
chr2_+_200776006	2.843		C2orf69	chromosome 2 open reading frame 69
chr5_-_180632110	2.835	NM_033342 NM_203293	TRIM7	tripartite motif containing 7
chr6_+_20404033	2.828	NM_001243076	E2F3	E2F transcription factor 3
chr6_-_159239198	2.825		EZR	ezrin
chr15_+_39873276	2.822	NM_003246	THBS1	thrombospondin 1
chr22_+_32340592	2.812		YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
chr22_+_25960885	2.805		ADRBK2	adrenergic, beta, receptor kinase 2
chr8_+_26149004	2.798	NM_002717	PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha
chr11_-_69490093	2.796	NM_153451	ORAOV1	oral cancer overexpressed 1
chr6_-_43543600	2.792		XPO5	exportin 5
chr19_-_1885462	2.790		FAM108A1	family with sequence similarity 108, member A1
chr17_-_3599359	2.788		P2RX5	purinergic receptor P2X, ligand-gated ion channel, 5
chr1_-_95392501	2.787	NM_001839	CNN3	calponin 3, acidic
chr20_-_62680880	2.783	NM_018419	SOX18	SRY (sex determining region Y)-box 18
chr16_-_47007567	2.783	NM_005880	DNAJA2	DnaJ (Hsp40) homolog, subfamily A, member 2
chrX_-_62570968	2.781	NM_001012968	SPIN4	spindlin family, member 4

Gene overrepresentation in process category:

Enrichment	P-value	GO Accession	GO Term
1.29	2.03e-05	GO:0044237	cellular metabolic process
1.38	2.85e-05	GO:0044260	cellular macromolecule metabolic process
1.25	6.56e-05	GO:0008152	metabolic process
1.28	7.71e-05	GO:0044238	primary metabolic process
1.14	1.53e-03	GO:0009987	cellular process
2.01	1.73e-03	GO:0042325	regulation of phosphorylation
1.98	1.95e-03	GO:0019220	regulation of phosphate metabolic process
1.98	1.95e-03	GO:0051174	regulation of phosphorus metabolic process
2.61	2.49e-03	GO:0071900	regulation of protein serine/threonine kinase activity
2.02	2.86e-03	GO:0001932	regulation of protein phosphorylation
1.76	3.85e-03	GO:0032268	regulation of cellular protein metabolic process
1.29	3.96e-03	GO:0043170	macromolecule metabolic process
3.49	4.35e-03	GO:0042254	ribosome biogenesis
2.18	4.46e-03	GO:0045859	regulation of protein kinase activity
2.14	5.36e-03	GO:0043549	regulation of kinase activity
2.11	5.66e-03	GO:0051338	regulation of transferase activity
1.70	9.66e-03	GO:0051246	regulation of protein metabolic process
1.82	1.48e-02	GO:0031399	regulation of protein modification process
1.52	2.05e-02	GO:0016070	RNA metabolic process
1.48	2.14e-02	GO:0043412	macromolecule modification
5.28	2.84e-02	GO:0001570	vasculogenesis
1.38	4.16e-02	GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.56	4.54e-02	GO:0009966	regulation of signal transduction
1.34	4.70e-02	GO:0006807	nitrogen compound metabolic process

Gene overrepresentation in compartment category:

Enrichment	P-value	GO Accession	GO Term
1.75	2.03e-10	GO:0044428	nuclear part
1.77	8.87e-09	GO:0031981	nuclear lumen
1.17	3.60e-08	GO:0044424	intracellular part
1.16	4.51e-08	GO:0005622	intracellular
2.42	1.30e-06	GO:0005730	nucleolus
1.58	1.54e-06	GO:0031974	membrane-enclosed lumen
1.58	2.40e-06	GO:0070013	intracellular organelle lumen
1.57	2.87e-06	GO:0043233	organelle lumen
1.31	4.59e-06	GO:0005634	nucleus
1.77	6.29e-06	GO:0005654	nucleoplasm
1.17	5.41e-05	GO:0043226	organelle
1.17	6.10e-05	GO:0043229	intracellular organelle
1.28	7.63e-05	GO:0044446	intracellular organelle part
1.19	8.91e-05	GO:0043227	membrane-bounded organelle
1.28	9.75e-05	GO:0044422	organelle part
1.19	1.12e-04	GO:0043231	intracellular membrane-bounded organelle
1.18	7.85e-04	GO:0005737	cytoplasm
2.60	1.91e-02	GO:0031252	cell leading edge

Gene overrepresentation in function category:

Enrichment	P-value	GO Accession	GO Term
1.57	3.66e-04	GO:0016740	transferase activity
1.21	1.13e-03	GO:0005515	protein binding
10.24	5.13e-03	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity
2.29	7.70e-03	GO:0016564	transcription repressor activity
1.71	7.94e-03	GO:0016772	transferase activity, transferring phosphorus-containing groups
9.51	8.63e-03	GO:0033549	MAP kinase phosphatase activity
1.52	9.58e-03	GO:0032559	adenyl ribonucleotide binding
1.51	1.20e-02	GO:0030554	adenyl nucleotide binding
1.51	1.43e-02	GO:0005524	ATP binding
1.76	1.59e-02	GO:0019899	enzyme binding
1.42	3.40e-02	GO:0032553	ribonucleotide binding
1.42	3.40e-02	GO:0032555	purine ribonucleotide binding
1.42	4.18e-02	GO:0035639	purine ribonucleoside triphosphate binding
1.42	4.29e-02	GO:0017076	purine nucleotide binding