Motif ID: HAND1,2.p2

Z-value: 1.606


Transcription factors associated with HAND1,2.p2:

Gene SymbolEntrez IDGene Name
HAND1 9421 heart and neural crest derivatives expressed 1
HAND2 9464 heart and neural crest derivatives expressed 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HAND2hg19_v1_chr4_-_174451356_1744513830.716.9e-13Click!


Activity profile for motif HAND1,2.p2.

activity profile for motif HAND1,2.p2


Sorted Z-values histogram for motif HAND1,2.p2

Sorted Z-values for motif HAND1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HAND1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_+_82660390 25.244 NM_001220488
NM_001220489
NM_001220490
NM_001220491
NM_001220492
NM_001257
CDH13





cadherin 13, H-cadherin (heart)





chr19_-_51456159 23.934 NM_001077491
NM_001077492
NM_012427
KLK5


kallikrein-related peptidase 5


chr19_-_51472003 17.419 NM_001012964
NM_001012965
KLK6

kallikrein-related peptidase 6

chr12_+_41086189 16.420 NM_001843
NM_175038
CNTN1

contactin 1

chr19_-_51504799 12.196 NM_007196
NM_144505
NM_144506
NM_144507
KLK8



kallikrein-related peptidase 8



chr17_-_56358266 11.020 NM_000250
MPO
myeloperoxidase
chr20_+_123230 10.875 NM_030931
DEFB126
defensin, beta 126
chr20_-_1165116 9.784 NM_018354
TMEM74B
transmembrane protein 74B
chr19_-_37701385 8.580 NM_152279
ZNF585B
zinc finger protein 585B
chr17_-_56358161 8.561 MPO
myeloperoxidase
chr7_-_83270746 8.325 NM_001178129
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr3_-_48601200 7.868 NM_033199
UCN2
urocortin 2
chr11_-_62996998 7.026 NM_199352
SLC22A25
solute carrier family 22, member 25
chr17_-_56358118 6.892 MPO
myeloperoxidase
chr18_+_28898051 6.752 NM_001942
DSG1
desmoglein 1
chr19_-_39264144 6.542 NM_002307
LGALS7
LGALS7B
lectin, galactoside-binding, soluble, 7
lectin, galactoside-binding, soluble, 7B
chr19_+_54415990 6.387 NM_031896
CACNG7
calcium channel, voltage-dependent, gamma subunit 7
chr5_+_59784004 6.266 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr14_-_88737160 6.210 NM_138318
KCNK10
potassium channel, subfamily K, member 10
chr2_+_204732509 6.166 NM_001037631
NM_005214
CTLA4

cytotoxic T-lymphocyte-associated protein 4

chr5_-_147286064 5.973 NM_206966
C5orf46
chromosome 5 open reading frame 46
chr6_-_31088195 5.854 NM_001264
CDSN
corneodesmosin
chrX_+_152770083 5.833 BGN
biglycan
chr1_+_11249344 5.788 NM_021146
ANGPTL7
angiopoietin-like 7
chr5_+_147443534 5.570 NM_001127698
NM_001127699
NM_006846
SPINK5


serine peptidase inhibitor, Kazal type 5


chr2_-_134179325 5.558 NCKAP5
NCK-associated protein 5
chr18_+_61420276 5.556 NM_001040147
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr1_+_228337414 5.545 NM_020435
GJC2
gap junction protein, gamma 2, 47kDa
chr7_-_142583260 5.474 NM_018646
TRPV6
transient receptor potential cation channel, subfamily V, member 6
chr12_-_110271205 5.470 NM_021625
TRPV4
transient receptor potential cation channel, subfamily V, member 4
chr22_+_41957011 5.417 NM_014460
CSDC2
cold shock domain containing C2, RNA binding
chr11_+_67171379 5.325 TBC1D10C
TBC1 domain family, member 10C
chr1_+_152769226 5.261 NM_178352
LCE1D
late cornified envelope 1D
chr9_-_107665959 5.222 ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr1_+_161676761 5.218 NM_001184866
NM_001184867
NM_001184870
NM_001184871
NM_001184872
NM_001184873
NM_032738
FCRLA






Fc receptor-like A






chr15_+_68908878 5.196 NM_001190456
CORO2B
coronin, actin binding protein, 2B
chr1_+_155911479 5.191 NM_181885
RXFP4
relaxin/insulin-like family peptide receptor 4
chr17_-_72619794 5.085 NM_181449
CD300E
CD300e molecule
chr22_-_32853372 4.936 NM_174932
BPIFC
BPI fold containing family C
chr10_+_18629613 4.914 NM_201590
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr5_+_36608430 4.877 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr6_+_134210247 4.778 NM_198392
NM_003206
TCF21

transcription factor 21

chr7_+_142560512 4.774 EPHB6
EPH receptor B6
chr16_-_46782104 4.735 NM_182493
MYLK3
myosin light chain kinase 3
chr12_-_53730003 4.625 NM_001173467
SP7
Sp7 transcription factor
chr2_+_231860838 4.615 NM_139073
SPATA3
spermatogenesis associated 3
chr1_-_183274008 4.538 NM_170706
NMNAT2
nicotinamide nucleotide adenylyltransferase 2
chr9_+_125132785 4.485 PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr6_+_134210264 4.462 TCF21
transcription factor 21
chr17_-_9923204 4.424 GAS7
growth arrest-specific 7
chr12_-_110252600 4.386 NM_001177431
NM_001177428
NM_001177433
NM_147204
TRPV4



transient receptor potential cation channel, subfamily V, member 4



chr18_+_61254533 4.384 NM_012397
SERPINB13
serpin peptidase inhibitor, clade B (ovalbumin), member 13
chr14_+_62462540 4.245 NM_031914
SYT16
synaptotagmin XVI
chr21_+_31768294 4.209 NM_181599
KRTAP13-1
keratin associated protein 13-1
chr5_-_149792370 4.183 NM_001025158
NM_001025159
NM_004355
CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chr7_-_84751246 4.179 NM_152754
SEMA3D
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
chr20_-_56285576 4.179 NM_199169
NM_199170
PMEPA1

prostate transmembrane protein, androgen induced 1

chr7_+_1127722 4.153 NM_001098201
GPER
G protein-coupled estrogen receptor 1
chr19_+_36359346 4.103 NM_001024807
NM_005166
APLP1

amyloid beta (A4) precursor-like protein 1

chr11_+_2323356 4.075 TSPAN32
tetraspanin 32
chr11_-_2158501 4.075


chr3_-_64211111 4.048 NM_198859
PRICKLE2
prickle homolog 2 (Drosophila)
chr11_+_2323236 4.034 NM_139022
TSPAN32
tetraspanin 32
chr7_+_28475233 3.993 NM_004904
CREB5
cAMP responsive element binding protein 5
chr11_+_89392464 3.987 NM_153696
FOLH1B
folate hydrolase 1B
chr2_-_31440378 3.977 NM_001145122
CAPN14
calpain 14
chr4_+_119947816 3.936 SYNPO2
synaptopodin 2
chr11_-_2158510 3.928 IGF2
insulin-like growth factor 2 (somatomedin A)
chr17_+_20483036 3.901 NM_001190790
CDRT15L2
CMT1A duplicated region transcript 15-like 2
chr6_+_36973409 3.899 NM_173558
FGD2
FYVE, RhoGEF and PH domain containing 2
chr12_-_53207843 3.896 NM_002272
KRT4
keratin 4
chr11_+_67171400 3.852 NM_198517
TBC1D10C
TBC1 domain family, member 10C
chr17_-_9923323 3.836 GAS7
growth arrest-specific 7
chrX_+_128913881 3.827 NM_018990
SASH3
SAM and SH3 domain containing 3
chr11_-_64527369 3.822 PYGM
phosphorylase, glycogen, muscle
chr1_+_26485510 3.821 NM_024869
FAM110D
family with sequence similarity 110, member D
chr12_+_113416267 3.782 NM_001032731
NM_002535
NM_016817
OAS2


2'-5'-oligoadenylate synthetase 2, 69/71kDa


chr14_+_96722546 3.772 NM_000710
BDKRB1
bradykinin receptor B1
chr11_+_71927818 3.741 NM_000803
NM_001113534
NM_001113535
NM_001113536
FOLR2



folate receptor 2 (fetal)



chr1_-_201081693 3.680 NM_000069
CACNA1S
calcium channel, voltage-dependent, L type, alpha 1S subunit
chr11_-_2323066 3.661 NM_001142946
C11orf21
chromosome 11 open reading frame 21
chr17_+_32582295 3.618 NM_002982
CCL2
chemokine (C-C motif) ligand 2
chr12_-_53729429 3.612 NM_152860
SP7
Sp7 transcription factor
chr9_+_125376947 3.609 NM_012364
OR1Q1
olfactory receptor, family 1, subfamily Q, member 1
chr1_+_152486977 3.587 NM_019060
CRCT1
cysteine-rich C-terminal 1
chr6_-_36304584 3.566 NM_001010903
C6orf222
chromosome 6 open reading frame 222
chr10_-_118032717 3.561 NM_001145453
GFRA1
GDNF family receptor alpha 1
chr19_-_12945376 3.532 RTBDN
retbindin
chr16_-_20338808 3.501 NM_001007240
NM_001007241
NM_001007242
NM_001502
GP2



glycoprotein 2 (zymogen granule membrane)



chr16_-_3149252 3.493 ZSCAN10
zinc finger and SCAN domain containing 10
chr12_-_110271182 3.485 TRPV4
transient receptor potential cation channel, subfamily V, member 4
chr5_-_149792276 3.478 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr11_+_6128913 3.476 NM_001005181
OR56B4
olfactory receptor, family 56, subfamily B, member 4
chr6_+_167525294 3.463 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chr10_+_82297657 3.456 NM_207372
SH2D4B
SH2 domain containing 4B
chr8_-_143858436 3.454 NM_177476
NM_177477
LYNX1

Ly6/neurotoxin 1

chr17_+_37784750 3.451 NM_001242464
NM_181505
PPP1R1B

protein phosphatase 1, regulatory (inhibitor) subunit 1B

chr20_+_29956420 3.419 NM_054112
DEFB118
defensin, beta 118
chr2_-_100939194 3.402 NM_198461
LONRF2
LON peptidase N-terminal domain and ring finger 2
chr12_-_57630867 3.399 NDUFA4L2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
chr7_-_81399286 3.386 NM_000601
NM_001010931
NM_001010932
NM_001010933
NM_001010934
HGF




hepatocyte growth factor (hepapoietin A; scatter factor)




chr18_+_55712867 3.363 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chrX_+_128913897 3.358 SASH3
SAM and SH3 domain containing 3
chr7_+_128506463 3.339 NM_001195150
LOC100130705
uncharacterized LOC100130705
chr1_+_26644458 3.336 CD52
CD52 molecule
chr19_-_17958773 3.328 JAK3
Janus kinase 3
chr1_-_167883243 3.300 NM_001167749
NM_018417
ADCY10

adenylate cyclase 10 (soluble)

chr16_-_90142332 3.300 NM_001098173
PRDM7
PR domain containing 7
chr19_+_55999859 3.260 NM_001144950
NM_001195267
SSC5D

scavenger receptor cysteine rich domain containing (5 domains)

chr16_+_78056411 3.251 NM_005752
CLEC3A
C-type lectin domain family 3, member A
chr9_+_125137600 3.237 PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr3_-_36781351 3.229 NM_033403
DCLK3
doublecortin-like kinase 3
chr8_-_93029864 3.216 NM_175636
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr11_-_133715368 3.207 NM_174927
SPATA19
spermatogenesis associated 19
chr19_-_51472816 3.205 NM_002774
KLK6
kallikrein-related peptidase 6
chr6_-_31689455 3.202 NM_025261
LY6G6C
lymphocyte antigen 6 complex, locus G6C
chr8_+_134203281 3.201 NM_001204869
NM_001204870
NM_003882
NM_080838
WISP1



WNT1 inducible signaling pathway protein 1



chr17_-_7991020 3.156 NM_001139
ALOX12B
arachidonate 12-lipoxygenase, 12R type
chr9_+_125132823 3.153 PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr1_+_154293568 3.134 NM_080429
AQP10
aquaporin 10
chrX_-_48328564 3.133 SLC38A5
solute carrier family 38, member 5
chr12_+_1929432 3.106 NM_001039029
NM_001163925
NM_001163926
LRTM2


leucine-rich repeats and transmembrane domains 2


chr15_-_29862926 3.093 NM_015307
FAM189A1
family with sequence similarity 189, member A1
chr14_+_75988765 3.083 NM_006399
BATF
basic leucine zipper transcription factor, ATF-like
chr9_+_72658496 3.071 NM_153267
MAMDC2
MAM domain containing 2
chr11_+_111411232 3.059 NM_178834
LAYN
layilin
chr13_+_113741668 3.058 MCF2L
MCF.2 cell line derived transforming sequence-like
chr10_-_76859247 3.016 NM_016364
DUSP13
dual specificity phosphatase 13
chr17_-_8770976 3.013 NM_001010855
PIK3R6
phosphoinositide-3-kinase, regulatory subunit 6
chr9_+_131870105 3.002


chr15_-_31393906 2.996 NM_001252024
NM_001252030
NM_002420
TRPM1


transient receptor potential cation channel, subfamily M, member 1


chr4_+_74281884 2.991 ALB
albumin
chr21_+_27012045 2.951 JAM2
junctional adhesion molecule 2
chr2_-_96150478 2.950 NM_001164464
TRIM43B
tripartite motif containing 43B
chr2_+_3642421 2.932 NM_024027
NM_199235
COLEC11

collectin sub-family member 11

chr11_-_7985041 2.929 NM_176821
NLRP10
NLR family, pyrin domain containing 10
chr10_-_99531712 2.911 NM_003015
SFRP5
secreted frizzled-related protein 5
chr14_+_75988838 2.881 BATF
basic leucine zipper transcription factor, ATF-like
chr22_+_31063914 2.872


chr14_-_107179043 2.870 IGHA1
immunoglobulin heavy constant alpha 1
chr16_+_29674564 2.853 SPN
sialophorin
chr16_+_57728711 2.848 NM_032269
CCDC135
coiled-coil domain containing 135
chr3_+_108015392 2.843 HHLA2
HERV-H LTR-associating 2
chr9_-_14910992 2.836 NM_144966
FREM1
FRAS1 related extracellular matrix 1
chr14_-_106518424 2.825 IGH@
IGHA1
IGHG1
IGHG2
IGHM
immunoglobulin heavy locus
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 2 (G2m marker)
immunoglobulin heavy constant mu
chr19_-_54804172 2.795 NM_001172654
NM_006865
LILRA3

LILRA6
leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3

leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
chr5_-_146460991 2.789 NM_181677
NM_181678
PPP2R2B

protein phosphatase 2, regulatory subunit B, beta

chr11_-_19223516 2.782 NM_001127656
NM_003476
CSRP3

cysteine and glycine-rich protein 3 (cardiac LIM protein)

chr3_-_97754147 2.777 NM_001105580
GABRR3
gamma-aminobutyric acid (GABA) receptor, rho 3
chr12_-_57410275 2.756 NM_001178054
NM_013251
TAC3

tachykinin 3

chr11_+_60869929 2.751 NM_014207
CD5
CD5 molecule
chr17_-_40337384 2.735 NM_001524
HCRT
hypocretin (orexin) neuropeptide precursor
chr20_+_16728997 2.732 NM_020157
OTOR
otoraplin
chr11_+_5602106 2.728 NM_001005162
OR52B6
olfactory receptor, family 52, subfamily B, member 6
chr19_+_49259343 2.714 NM_019113
FGF21
fibroblast growth factor 21
chr5_+_36606456 2.710 NM_001166696
NM_004172
SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

chr5_+_36606667 2.707 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr9_+_72658735 2.701 MAMDC2
MAM domain containing 2
chr10_-_75401492 2.695 NM_021245
MYOZ1
myozenin 1
chr14_+_21359542 2.691 NM_002935
RNASE3
ribonuclease, RNase A family, 3
chr3_+_123813527 2.690 NM_001024660
NM_003947
KALRN

kalirin, RhoGEF kinase

chrX_+_106143393 2.640 NM_001171092
CLDN2
claudin 2
chr16_+_6069094 2.635 NM_001142333
NM_018723
RBFOX1

RNA binding protein, fox-1 homolog (C. elegans) 1

chr9_-_100700422 2.619 NM_197978
HEMGN
hemogen
chr4_+_15376174 2.593 NM_001135171
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr2_+_96257765 2.579 NM_138800
TRIM43
tripartite motif containing 43
chr18_+_61223392 2.573 NM_080474
SERPINB12
serpin peptidase inhibitor, clade B (ovalbumin), member 12
chr11_-_70672644 2.549 SHANK2
SH3 and multiple ankyrin repeat domains 2
chr16_-_10788729 2.517 NM_144674
TEKT5
tektin 5
chr3_+_46919235 2.514 NM_000316
PTH1R
parathyroid hormone 1 receptor
chr6_-_55740387 2.500 BMP5
bone morphogenetic protein 5
chr2_+_219221578 2.487 NM_198559
C2orf62
chromosome 2 open reading frame 62
chr14_+_105391150 2.487 PLD4
phospholipase D family, member 4
chr8_-_103137134 2.456 NM_001040630
NCALD
neurocalcin delta
chr19_+_55235951 2.450 NM_153443
KIR3DL3
KIR2DL3
killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3
killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
chr11_-_64764388 2.448 NM_138456
BATF2
basic leucine zipper transcription factor, ATF-like 2
chr1_-_23521221 2.441 NM_000864
HTR1D
5-hydroxytryptamine (serotonin) receptor 1D
chr12_+_100750856 2.440 NM_001145288
NM_139319
SLC17A8

solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8

chr2_-_31637598 2.439 NM_000379
XDH
xanthine dehydrogenase
chr8_-_38008332 2.436 NM_000349
STAR
steroidogenic acute regulatory protein
chr5_+_148786439 2.421 MIR143HG
MIR143 host gene (non-protein coding)
chr19_+_40267233 2.417 NM_001143832
LEUTX
leucine twenty homeobox
chr17_+_40913233 2.385 RAMP2
receptor (G protein-coupled) activity modifying protein 2
chr6_-_46889620 2.383 NM_001098518
GPR116
G protein-coupled receptor 116
chr19_-_56904869 2.382 NM_144690
ZNF582
zinc finger protein 582
chr2_-_167343477 2.374 NM_002976
SCN7A
sodium channel, voltage-gated, type VII, alpha
chr5_+_140220811 2.371 NM_018911
NM_031856
PCDHA8

protocadherin alpha 8

chrX_+_70364728 2.364 NLGN3
neuroligin 3
chr14_+_105391215 2.357 PLD4
phospholipase D family, member 4
chrX_-_13338517 2.343 NM_001135995
ATXN3L
ataxin 3-like
chr14_+_74083547 2.334 NM_001037162
ACOT6
acyl-CoA thioesterase 6
chr11_+_111411419 2.331 LAYN
layilin
chr2_+_97202463 2.329 NM_212481
ARID5A
AT rich interactive domain 5A (MRF1-like)
chr19_+_50016500 2.324 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr15_+_40643225 2.320 NM_001145643
PHGR1
proline/histidine/glycine-rich 1
chr10_-_118032975 2.309 NM_005264
GFRA1
GDNF family receptor alpha 1
chr16_+_21245015 2.293 NM_145865
ANKS4B
ankyrin repeat and sterile alpha motif domain containing 4B
chr12_-_117799410 2.292 NM_000620
NM_001204218
NOS1

nitric oxide synthase 1 (neuronal)

chr6_-_34524083 2.288 NM_001252294
NM_012391
SPDEF

SAM pointed domain containing ets transcription factor

chr1_-_160549226 2.283 CD84
CD84 molecule

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.42 2.01e-04 GO:0032501 multicellular organismal process

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
2.03 2.01e-09 GO:0005576 extracellular region
1.57 2.29e-07 GO:0071944 cell periphery
1.57 2.99e-07 GO:0005886 plasma membrane
1.82 1.81e-06 GO:0044459 plasma membrane part
1.94 4.19e-04 GO:0005887 integral to plasma membrane
1.36 4.70e-04 GO:0031224 intrinsic to membrane
1.90 7.38e-04 GO:0031226 intrinsic to plasma membrane
1.30 1.68e-03 GO:0044425 membrane part
1.24 5.08e-03 GO:0016020 membrane
1.89 6.58e-03 GO:0044421 extracellular region part
2.02 8.89e-03 GO:0005615 extracellular space
1.31 9.20e-03 GO:0016021 integral to membrane
3.85 1.51e-02 GO:0031225 anchored to membrane

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
10.18 9.93e-06 GO:0003823 antigen binding
1.81 2.54e-04 GO:0004872 receptor activity
5.29 5.71e-03 GO:0005262 calcium channel activity
1.60 6.70e-03 GO:0004871 signal transducer activity
1.60 6.70e-03 GO:0060089 molecular transducer activity
2.45 1.73e-02 GO:0015267 channel activity
2.44 1.80e-02 GO:0022803 passive transmembrane transporter activity
13.57 4.72e-02 GO:0005313 L-glutamate transmembrane transporter activity
13.57 4.72e-02 GO:0015172 acidic amino acid transmembrane transporter activity