Motif ID: GUGCAAA

Z-value: 1.112


Mature miRNA associated with seed GUGCAAA:

NamemiRBase Accession
hsa-miR-19a MIMAT0000073
hsa-miR-19b MIMAT0000074



Activity profile for motif GUGCAAA.

activity profile for motif GUGCAAA


Sorted Z-values histogram for motif GUGCAAA

Sorted Z-values for motif GUGCAAA



Network of associatons between targets according to the STRING database.



First level regulatory network of GUGCAAA

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_30454396 16.906 NM_030915
LBH
limb bud and heart development homolog (mouse)
chr11_+_69924407 10.781 NM_018043
ANO1
anoctamin 1, calcium activated chloride channel
chr11_+_43963809 9.258 NM_001145033
C11orf96
chromosome 11 open reading frame 96
chr1_+_92495484 8.830 NM_173567
EPHX4
epoxide hydrolase 4
chr8_-_22550057 8.445 NM_001199881
EGR3
early growth response 3
chr8_-_22549901 8.329 NM_001199880
EGR3
early growth response 3
chr8_-_22550708 8.088 NM_004430
EGR3
early growth response 3
chr3_-_64211111 7.964 NM_198859
PRICKLE2
prickle homolog 2 (Drosophila)
chr8_-_124544376 7.589 NM_148177
FBXO32
F-box protein 32
chr2_-_1748285 7.290 NM_012293
PXDN
peroxidasin homolog (Drosophila)
chr8_-_124553448 6.984 NM_001242463
NM_058229
FBXO32

F-box protein 32

chr5_+_140254930 6.570 NM_018903
NM_031864
PCDHA12

protocadherin alpha 12

chr7_+_128470462 6.467 NM_001127487
NM_001458
FLNC

filamin C, gamma

chr6_-_132272311 6.284 NM_001901
CTGF
connective tissue growth factor
chr5_-_136834887 6.081 NM_004598
SPOCK1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
chr17_-_48072566 5.672 NM_005220
DLX3
distal-less homeobox 3
chr2_-_86564632 5.354 NM_001164731
NM_001164732
NM_022912
REEP1


receptor accessory protein 1


chr11_-_12030128 5.232 NM_001018057
DKK3
dickkopf 3 homolog (Xenopus laevis)
chr2_+_219745243 5.097 NM_025216
WNT10A
wingless-type MMTV integration site family, member 10A
chr6_+_160769365 4.849 NM_021977
SLC22A3
solute carrier family 22 (extraneuronal monoamine transporter), member 3
chr2_-_197457250 4.755 NM_020760
HECW2
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
chr22_-_30642683 4.570 NM_002309
LIF
leukemia inhibitory factor (cholinergic differentiation factor)
chr3_-_124774735 4.433 NM_020733
HEG1
HEG homolog 1 (zebrafish)
chr10_-_30348433 4.417 NM_020848
KIAA1462
KIAA1462
chr7_-_45960738 4.383 NM_000598
NM_001013398
IGFBP3

insulin-like growth factor binding protein 3

chr22_-_39548448 4.348 NM_175709
CBX7
chromobox homolog 7
chr14_+_70346113 4.323 NM_001034852
NM_022137
SMOC1

SPARC related modular calcium binding 1

chr17_-_19770988 4.263 NM_001142610
NM_014683
ULK2

unc-51-like kinase 2 (C. elegans)

chr1_-_40367539 4.262 NM_001033081
NM_001033082
NM_005376
MYCL1


v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)


chr15_+_39873276 3.925 NM_003246
THBS1
thrombospondin 1
chr17_-_76356153 3.855 NM_003955
SOCS3
suppressor of cytokine signaling 3
chr5_+_140165875 3.752 NM_018900
NM_031410
NM_031411
PCDHA1


protocadherin alpha 1


chr20_+_36531498 3.732 NM_080607
VSTM2L
V-set and transmembrane domain containing 2 like
chrX_+_84498993 3.717 NM_021998
ZNF711
zinc finger protein 711
chr6_+_46097700 3.629 NM_014936
ENPP4
ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
chr6_+_136172802 3.607 NM_018945
PDE7B
phosphodiesterase 7B
chr2_-_225907312 3.584 NM_014689
DOCK10
dedicator of cytokinesis 10
chr2_+_20646831 3.458 NM_004040
RHOB
ras homolog gene family, member B
chr6_-_134497069 3.431 NM_001143678
SGK1
serum/glucocorticoid regulated kinase 1
chr12_+_79439432 3.420 NM_001135806
SYT1
synaptotagmin I
chr5_+_140247767 3.383 NM_018902
NM_031861
PCDHA11

protocadherin alpha 11

chr2_-_160761266 3.338 NM_001198759
NM_001198760
NM_002349
LY75-CD302

LY75
LY75-CD302 readthrough

lymphocyte antigen 75
chr6_-_134498973 3.324 NM_001143677
SGK1
serum/glucocorticoid regulated kinase 1
chr1_-_45956795 3.324 NM_007170
TESK2
testis-specific kinase 2
chr6_+_89790412 3.207 NM_006813
PNRC1
proline-rich nuclear receptor coactivator 1
chr6_-_134496006 3.185 NM_005627
SGK1
serum/glucocorticoid regulated kinase 1
chr2_+_189156395 3.182 NM_001252668
NM_001252669
NM_016315
GULP1


GULP, engulfment adaptor PTB domain containing 1


chr12_+_79257772 3.167 NM_001135805
SYT1
synaptotagmin I
chr6_-_46138584 3.134 NM_021572
ENPP5
ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)
chr5_-_1112106 3.111 NM_006598
SLC12A7
solute carrier family 12 (potassium/chloride transporters), member 7
chr12_+_79258448 3.094 NM_005639
SYT1
synaptotagmin I
chr5_-_137071703 3.090 NM_017415
KLHL3
kelch-like 3 (Drosophila)
chr5_+_140235594 3.050 NM_018901
NM_031859
NM_031860
PCDHA10


protocadherin alpha 10


chr6_-_134639195 3.017 NM_001143676
SGK1
serum/glucocorticoid regulated kinase 1
chr3_+_174577069 3.010 NM_207015
NAALADL2
N-acetylated alpha-linked acidic dipeptidase-like 2
chr8_-_17658385 2.970 NM_001001924
NM_001001925
MTUS1

microtubule associated tumor suppressor 1

chr6_+_19837599 2.887 NM_001546
ID4
inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
chr11_-_74109417 2.874 NM_173582
PGM2L1
phosphoglucomutase 2-like 1
chr9_-_131534186 2.859 NM_006336
ZER1
zer-1 homolog (C. elegans)
chr5_+_140207562 2.847 NM_018909
NM_031848
NM_031849
PCDHA6


protocadherin alpha 6


chr2_+_191273012 2.836 NM_017694
MFSD6
major facilitator superfamily domain containing 6
chr7_-_79082870 2.833 NM_012301
MAGI2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr11_+_27015627 2.827 NM_203371
FIBIN
fin bud initiation factor homolog (zebrafish)
chr12_-_53893195 2.811 NM_001193511
NM_006301
MAP3K12

mitogen-activated protein kinase kinase kinase 12

chr12_-_92539614 2.806 NM_001731
BTG1
B-cell translocation gene 1, anti-proliferative
chr18_+_3453771 2.785 NM_173211
TGIF1
TGFB-induced factor homeobox 1
chr6_-_116381765 2.784 NM_002031
FRK
fyn-related kinase
chr8_-_95961543 2.778 NM_001135733
NM_033285
TP53INP1

tumor protein p53 inducible nuclear protein 1

chr8_-_103667882 2.723 NM_005655
KLF10
Kruppel-like factor 10
chr18_+_3447607 2.719 NM_173207
TGIF1
TGFB-induced factor homeobox 1
chr5_+_140345746 2.717 NM_018899
PCDHAC2
protocadherin alpha subfamily C, 2
chr18_+_3412071 2.696 NM_174886
TGIF1
TGFB-induced factor homeobox 1
chr14_-_60337350 2.694 NM_021136
RTN1
reticulon 1
chr9_-_14398981 2.677 NM_001190738
NFIB
nuclear factor I/B
chr1_+_155829259 2.653 NM_152280
SYT11
synaptotagmin XI
chr2_+_8822112 2.634 NM_002166
ID2
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
chr15_+_84322809 2.632 NM_207517
ADAMTSL3
ADAMTS-like 3
chr3_+_152880024 2.618 NM_002886
RAP2B
RAP2B, member of RAS oncogene family
chr7_+_20370724 2.578 NM_002214
ITGB8
integrin, beta 8
chr13_+_97874540 2.554 NM_144778
NM_207304
MBNL2

muscleblind-like 2 (Drosophila)

chr17_-_56406120 2.534 NM_004758
NM_024418
BZRAP1

benzodiazapine receptor (peripheral) associated protein 1

chr18_+_3449972 2.502 NM_173209
NM_173208
NM_003244
TGIF1


TGFB-induced factor homeobox 1


chr9_-_14314036 2.494 NM_001190737
NM_005596
NFIB

nuclear factor I/B

chr10_-_43762366 2.491 NM_145313
RASGEF1A
RasGEF domain family, member 1A
chr1_+_183605207 2.485 NM_015149
RGL1
ral guanine nucleotide dissociation stimulator-like 1
chr6_-_111136407 2.476 NM_015076
CDK19
cyclin-dependent kinase 19
chr5_+_140306301 2.460 NM_018898
NM_031882
PCDHAC1

protocadherin alpha subfamily C, 1

chr10_+_112404104 2.454 NM_001134363
RBM20
RNA binding motif protein 20
chr11_-_16424391 2.424 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr11_-_17035948 2.415 NM_175058
PLEKHA7
pleckstrin homology domain containing, family A member 7
chr2_+_101436491 2.349 NM_002518
NPAS2
neuronal PAS domain protein 2
chr8_-_103666018 2.348 NM_001032282
KLF10
Kruppel-like factor 10
chr5_+_140180782 2.322 NM_018906
NM_031497
PCDHA3

protocadherin alpha 3

chr22_-_28197469 2.301 NM_002430
MN1
meningioma (disrupted in balanced translocation) 1
chr11_-_12030882 2.278 NM_013253
DKK3
dickkopf 3 homolog (Xenopus laevis)
chr3_+_100211408 2.273 NM_018004
TMEM45A
transmembrane protein 45A
chr7_+_106809405 2.221 NM_001244262
NM_012257
HBP1

HMG-box transcription factor 1

chr18_+_3451589 2.175 NM_170695
NM_173210
TGIF1

TGFB-induced factor homeobox 1

chr6_+_138188352 2.175 NM_006290
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr7_+_89840999 2.171 NM_001244944
NM_001244945
NM_152999
NM_001040665
NM_001244946
STEAP2




STEAP family member 2, metalloreductase




chr5_+_71403040 2.164 NM_005909
MAP1B
microtubule-associated protein 1B
chr5_+_140186658 2.158 NM_018907
NM_031500
PCDHA4

protocadherin alpha 4

chr6_+_152128685 2.151 NM_000125
ESR1
estrogen receptor 1
chr11_-_12030622 2.116 NM_015881
DKK3
dickkopf 3 homolog (Xenopus laevis)
chr5_+_140201221 2.019 NM_018908
NM_031501
PCDHA5

protocadherin alpha 5

chrX_-_10645726 1.920 NM_001098624
MID1
midline 1 (Opitz/BBB syndrome)
chr11_-_16430425 1.911 NM_001145811
SOX6
SRY (sex determining region Y)-box 6
chr10_+_97889467 1.876 NM_014803
ZNF518A
zinc finger protein 518A
chr5_+_140220811 1.871 NM_018911
NM_031856
PCDHA8

protocadherin alpha 8

chr8_-_110657025 1.871 NM_001099753
NM_001099754
NM_001099755
SYBU


syntabulin (syntaxin-interacting)


chr2_-_86565205 1.867 NM_001164730
REEP1
receptor accessory protein 1
chr8_-_110704019 1.864 NM_001099743
NM_001099744
SYBU

syntabulin (syntaxin-interacting)

chr7_-_112579726 1.827 NM_152556
C7orf60
chromosome 7 open reading frame 60
chr10_+_89623091 1.823 NM_000314
PTEN
phosphatase and tensin homolog
chr6_+_121756744 1.811 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr8_-_110661007 1.795 NM_001099747
NM_001099748
NM_001099749
NM_001099750
NM_017786
SYBU




syntabulin (syntaxin-interacting)




chr11_-_16497917 1.784 NM_033326
SOX6
SRY (sex determining region Y)-box 6
chr1_+_151483861 1.784 NM_020770
CGN
cingulin
chr3_-_18466759 1.773 NM_001195470
NM_002971
SATB1

SATB homeobox 1

chr3_+_50712671 1.765 NM_004947
DOCK3
dedicator of cytokinesis 3
chr6_+_21593963 1.729 NM_003107
SOX4
SRY (sex determining region Y)-box 4
chr5_+_140213968 1.729 NM_018910
NM_031852
PCDHA7

protocadherin alpha 7

chr8_-_110657745 1.717 NM_001099751
NM_001099752
SYBU

syntabulin (syntaxin-interacting)

chr12_-_22697439 1.713 NM_014802
KIAA0528
KIAA0528
chr11_+_121322848 1.674 NM_003105
SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr1_+_207627614 1.667 NM_001006658
NM_001877
CR2

complement component (3d/Epstein Barr virus) receptor 2

chrX_-_10588458 1.667 NM_000381
NM_033289
MID1

midline 1 (Opitz/BBB syndrome)

chr3_+_77089248 1.666 NM_002942
ROBO2
roundabout, axon guidance receptor, homolog 2 (Drosophila)
chr8_-_110693233 1.664 NM_001099745
NM_001099746
SYBU

syntabulin (syntaxin-interacting)

chr4_-_122854192 1.615 NM_003305
TRPC3
transient receptor potential cation channel, subfamily C, member 3
chr16_-_14788429 1.587 NM_003561
PLA2G10
phospholipase A2, group X
chr20_-_56286540 1.583 NM_199171
PMEPA1
prostate transmembrane protein, androgen induced 1
chr20_-_56285576 1.580 NM_199169
NM_199170
PMEPA1

prostate transmembrane protein, androgen induced 1

chr20_+_8112762 1.576 NM_015192
NM_182734
PLCB1

phospholipase C, beta 1 (phosphoinositide-specific)

chr17_-_61777478 1.566 NM_030576
LIMD2
LIM domain containing 2
chr3_+_184279539 1.547 NM_004443
EPHB3
EPH receptor B3
chr4_+_87856152 1.536 NM_001166693
AFF1
AF4/FMR2 family, member 1
chr10_+_23728197 1.504 NM_001145373
OTUD1
OTU domain containing 1
chr10_-_61666236 1.482 NM_005436
CCDC6
coiled-coil domain containing 6
chr1_+_6673744 1.465 NM_153812
PHF13
PHD finger protein 13
chr8_-_110655418 1.461 NM_001099756
SYBU
syntabulin (syntaxin-interacting)
chr11_+_118401755 1.448 NM_001144034
NM_001144035
NM_001144036
NM_001144037
NM_001144038
NM_032780
TMEM25





transmembrane protein 25





chr15_+_48010685 1.446 NM_020858
NM_024966
NM_153616
NM_153617
NM_153618
NM_153619
SEMA6D





sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D





chr14_+_59655351 1.432 NM_014992
DAAM1
dishevelled associated activator of morphogenesis 1
chr3_-_18480203 1.427 NM_001131010
SATB1
SATB homeobox 1
chr2_+_198669316 1.426 NM_006226
PLCL1
phospholipase C-like 1
chr16_+_4382224 1.416 NM_032575
GLIS2
GLIS family zinc finger 2
chr3_+_43732358 1.408 NM_016006
ABHD5
abhydrolase domain containing 5
chr5_-_158637060 1.407 NM_001199380
RNF145
ring finger protein 145
chr1_-_214724974 1.397 NM_005401
PTPN14
protein tyrosine phosphatase, non-receptor type 14
chr12_-_64616032 1.385 NM_152440
C12orf66
chromosome 12 open reading frame 66
chr11_+_8060179 1.383 NM_003320
TUB
tubby homolog (mouse)
chr12_+_12938540 1.380 NM_030817
APOLD1
apolipoprotein L domain containing 1
chr7_-_98741681 1.371 NM_001199847
NM_020429
NM_181349
SMURF1


SMAD specific E3 ubiquitin protein ligase 1


chr2_-_182545212 1.359 NM_002500
CERKL
NEUROD1
ceramide kinase-like
neurogenic differentiation 1
chr4_+_87928083 1.358 NM_005935
AFF1
AF4/FMR2 family, member 1
chr5_-_100238870 1.353 NM_175052
NM_005668
ST8SIA4

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4

chrX_+_44732402 1.351 NM_021140
KDM6A
lysine (K)-specific demethylase 6A
chrX_-_10851808 1.351 NM_033290
MID1
midline 1 (Opitz/BBB syndrome)
chr12_-_111021026 1.343 NM_139283
PPTC7
PTC7 protein phosphatase homolog (S. cerevisiae)
chr5_-_158636489 1.340 NM_001199383
RNF145
ring finger protein 145
chr16_+_50775960 1.334 NM_001042355
NM_015247
CYLD

cylindromatosis (turban tumor syndrome)

chr11_-_8190535 1.322 NM_001135109
NM_001206671
NM_001206672
NM_024557
RIC3



resistance to inhibitors of cholinesterase 3 homolog (C. elegans)



chr7_-_14025826 1.319 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr17_+_45331154 1.315 NM_000212
ITGB3
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
chr1_-_160232286 1.314 NM_015726
DCAF8
DDB1 and CUL4 associated factor 8
chr9_-_23821477 1.304 NM_001171197
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chrX_+_17653412 1.299 NM_001136024
NHS
Nance-Horan syndrome (congenital cataracts and dental anomalies)
chr9_-_23826062 1.293 NM_004432
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr16_-_11350038 1.283 NM_003745
SOCS1
suppressor of cytokine signaling 1
chr1_+_42846427 1.282 NM_173642
RIMKLA
ribosomal modification protein rimK-like family member A
chr3_-_184870727 1.281 NM_001025266
C3orf70
chromosome 3 open reading frame 70
chr16_+_50776012 1.269 NM_001042412
CYLD
cylindromatosis (turban tumor syndrome)
chr14_+_65007163 1.262 NM_021979
HSPA2
heat shock 70kDa protein 2
chr6_-_16761600 1.257 NM_000332
NM_001128164
ATXN1

ataxin 1

chr8_-_12973752 1.242 NM_001164271
DLC1
deleted in liver cancer 1
chr3_+_102153858 1.242 NM_175056
ZPLD1
zona pellucida-like domain containing 1
chr17_-_73851377 1.240 NM_012478
WBP2
WW domain binding protein 2
chr20_-_3388219 1.230 NM_001009984
C20orf194
chromosome 20 open reading frame 194
chr8_-_12990731 1.226 NM_006094
DLC1
deleted in liver cancer 1
chr6_+_152011630 1.221 NM_001122742
ESR1
estrogen receptor 1
chr3_-_87040246 1.220 NM_016206
VGLL3
vestigial like 3 (Drosophila)
chr14_+_52781004 1.214 NM_000956
PTGER2
prostaglandin E receptor 2 (subtype EP2), 53kDa
chr10_+_63661012 1.211 NM_032199
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr9_-_23821842 1.202 NM_001171195
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr20_-_5591487 1.193 NM_019593
GPCPD1
glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)
chrX_-_10544852 1.192 NM_001193277
MID1
midline 1 (Opitz/BBB syndrome)
chr5_+_140261792 1.190 NM_018904
NM_031865
PCDHA13

protocadherin alpha 13

chr11_+_111848008 1.185 NM_033425
DIXDC1
DIX domain containing 1
chr7_-_75368276 1.169 NM_001243198
NM_005338
HIP1

huntingtin interacting protein 1

chr2_-_208890207 1.148 NM_001080475
PLEKHM3
pleckstrin homology domain containing, family M, member 3
chr7_-_105319608 1.143 NM_138495
ATXN7L1
ataxin 7-like 1
chr15_+_98503907 1.138 NM_183376
ARRDC4
arrestin domain containing 4
chr5_-_158635080 1.137 NM_001199381
RNF145
ring finger protein 145
chr19_+_11200037 1.136 NM_000527
NM_001195798
NM_001195799
NM_001195800
NM_001195802
NM_001195803
LDLR





low density lipoprotein receptor





chr12_-_120315074 1.132 NM_001206999
NM_007174
CIT

citron (rho-interacting, serine/threonine kinase 21)

chr2_-_68694389 1.132 NM_001024680
FBXO48
F-box protein 48
chrX_+_17393537 1.110 NM_198270
NHS
Nance-Horan syndrome (congenital cataracts and dental anomalies)
chr11_+_111807857 1.104 NM_001037954
DIXDC1
DIX domain containing 1
chr8_-_143695812 1.100 NM_015193
ARC
activity-regulated cytoskeleton-associated protein

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
11.94 1.75e-09 GO:0007156 homophilic cell adhesion
2.30 4.38e-07 GO:0048731 system development
6.36 1.35e-06 GO:0016337 cell-cell adhesion
2.92 2.06e-06 GO:0007399 nervous system development
2.14 3.02e-06 GO:0048856 anatomical structure development
2.00 3.36e-06 GO:0032502 developmental process
3.66 3.22e-05 GO:0007155 cell adhesion
3.66 3.22e-05 GO:0022610 biological adhesion
1.96 8.09e-05 GO:0007275 multicellular organismal development
2.93 3.18e-03 GO:0050793 regulation of developmental process
3.08 6.85e-03 GO:2000026 regulation of multicellular organismal development
9.36 8.39e-03 GO:0032355 response to estradiol stimulus
2.06 9.35e-03 GO:0048523 negative regulation of cellular process
4.26 2.34e-02 GO:0060284 regulation of cell development
1.93 3.18e-02 GO:0048519 negative regulation of biological process
3.57 3.51e-02 GO:0051094 positive regulation of developmental process
39.10 4.00e-02 GO:0045663 positive regulation of myoblast differentiation
1.52 4.07e-02 GO:0032501 multicellular organismal process
2.70 4.55e-02 GO:0048699 generation of neurons
2.41 4.74e-02 GO:0010604 positive regulation of macromolecule metabolic process

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.63 4.34e-03 GO:0005886 plasma membrane
1.61 6.81e-03 GO:0071944 cell periphery
1.90 1.35e-02 GO:0044459 plasma membrane part
2.26 1.73e-02 GO:0005887 integral to plasma membrane
2.21 2.32e-02 GO:0031226 intrinsic to plasma membrane

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
3.99 1.14e-06 GO:0005509 calcium ion binding